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Journal articles on the topic 'Methods photoreception'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Lander, A., M. Burge, B. Thomas, A. Phillips, E. McGlashan, and S. Cain. "O023 Circadian Photoreception Influences Loss Aversion." Sleep Advances 5, Supplement_1 (2024): A9. https://doi.org/10.1093/sleepadvances/zpae070.023.

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Abstract Introduction Gambling behaviour is a growing societal problem. While previous work has explored how sound encourages gambling, an unexplored element that may play a role is the impact of circadian photoreception on cognitive processes underlying this behaviour. This study investigated the influence of circadian photoreception on loss aversion in gambling by altering the blue content of light while maintaining the same visual brightness (200 lux). Methods Fifteen participants (5 male, M = 20.40, SD = 2.03) completed an economic decision-making task under blue-enriched and blue-depleted

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Garza, Z. C. Félix, M. Born, P. A. J. Hilbers, N. A. W. van Riel, and J. Liebmann. "Visible Blue Light Therapy: Molecular Mechanisms and Therapeutic Opportunities." Current Medicinal Chemistry 25, no. 40 (2019): 5564–77. http://dx.doi.org/10.2174/0929867324666170727112206.

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Background: Visible light is absorbed by photoacceptors in pigmented and non-pigmented mammalian cells, activating signaling cascades and downstream mechanisms that lead to the modulation of cellular processes. Most studies have investigated the molecular mechanisms and therapeutic applications of UV and the red to near infrared regions of the visible spectrum. Considerably less effort has been dedicated to the blue, UV-free part of the spectrum. Objective: In this review, we discuss the current advances in the understanding of the molecular photoacceptors, signaling mechanisms, and correspond

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Converse, C. A. "Methods in neurosciences, Vol. 15; Photoreceptor cells." Neurochemistry International 25, no. 3 (1994): 301. http://dx.doi.org/10.1016/0197-0186(94)90074-4.

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Xiao, Yu-Shu, Min Gao, Jun-Ran Sun, et al. "Deletion of prominin-1 in mice results in disrupted photoreceptor outer segment protein homeostasis." International Journal of Ophthalmology 14, no. 9 (2021): 1334–44. http://dx.doi.org/10.18240/ijo.2021.09.07.

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AIM: To illustrate the underlying mechanism how prominin-1 (also known as Prom1) mutation contribute to progressive photoreceptor degeneration. METHODS: A CRISPR-mediated Prom1 knockout (Prom1-KO) mice model in the C57BL/6 was generated and the photoreceptor degeneration phenotypes by means of structural and functional tests were demonstrated. Immunohistochemistry and immunoblot analysis were performed to reveal the localization and quantity of related outer segment (OS) proteins. RESULTS: The Prom1-KO mice developed the photoreceptor degeneration phenotype including the decreased outer nuclea

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Rosinvil, Thaïna, Veronique Daneault, Gilles Vanderwalle, et al. "280 Is blue-enriched light more effective than red light to enhance vigilance and cognitive performance in Parkinson’s Disease?" Sleep 44, Supplement_2 (2021): A112—A113. http://dx.doi.org/10.1093/sleep/zsab072.279.

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Abstract Introduction Approximately 50% (between 16–74%) of adults with Parkinson’s disease (PD) show excessive daytime sleepiness. Besides its important role for vision, light conveys a powerful stimulating signal for alertness and cognition. Recent research has demonstrated that the blue part of light spectrum is the most efficient in enhancing vigilance and cognitive performance in young and older healthy individuals, thanks to a specific photoreception system within the eye which is particularly sensitive to blue wavelength. The aim of this pilot study was to compare the effects of blue-en

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Dubicanac, Marko, Julia Strueve, Nadine Mestre-Frances, Jean-Michel Verdier, Elke Zimmermann, and Marine Joly. "Photoperiodic regime influences onset of lens opacities in a non-human primate." PeerJ 5 (May 4, 2017): e3258. http://dx.doi.org/10.7717/peerj.3258.

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Background Opacities of the lens are typical age-related phenomena which have a high influence on photoreception and consequently circadian rhythm. In mouse lemurs, a small bodied non-human primate, a high incidence (more than 50% when >seven years) of cataracts has been previously described during aging. Previous studies showed that photoperiodically induced accelerated annual rhythms alter some of mouse lemurs’ life history traits. Whether a modification of photoperiod also affects the onset of age dependent lens opacities has not been investigated so far. The aim of this study was theref

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Стрельников, V. Strelnikov, Рогова, et al. "Macular Electroretinography and Methods of Retina Visualization in Diagnostics of Standard Stargardt Disease, Verified by Molecular Genetic Methods." Journal of New Medical Technologies. eJournal 8, no. 1 (2014): 1–8. http://dx.doi.org/10.12737/2827.

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The aim of the study was to assess the data concerning the modern methods of retina visualization (optical coherence tomography and autofluorescence) and its interrelation with the data concerning the modern elec-troretinographic methods for research of Stargardt desease, verified with the help of molecular genetic methods. It was found that the shift of macular electroretinogramm to the red stimulus correlates with the parameters of optic coherent tomography: inverse high correlation between the &#34;transverse defect&#34; and a-wave amplitude of macular electroretinogramm (r=-0,83, p

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Lessios, Nicolas. "Using electroretinograms and multi-model inference to identify spectral classes of photoreceptors and relative opsin expression levels." PeerJ 5 (July 21, 2017): e3595. http://dx.doi.org/10.7717/peerj.3595.

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Understanding how individual photoreceptor cells factor in the spectral sensitivity of a visual system is essential to explain how they contribute to the visual ecology of the animal in question. Existing methods that model the absorption of visual pigments use templates which correspond closely to data from thin cross-sections of photoreceptor cells. However, few modeling approaches use a single framework to incorporate physical parameters of real photoreceptors, which can be fused, and can form vertical tiers. Akaike’s information criterion (AICc) was used here to select absorptance models o

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Yusupov, Azamat, Mukhiddin Ziyoviddinov, Shavkat Mukhanov, and O. O. Sobirov. "FUNCTIONAL METHODS OF EARLY DIAGNOSTICS OF AGE MACULAR DEGENERATION.(LITERATURE REVIEW)." UZBEK MEDICAL JOURNAL Special issue, no. 2 (2021): 61–67. http://dx.doi.org/10.26739/2181-0664-2021-si-2-10.

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This article provides an unsystematic literature review devoted to analyzing the currently existing methods of functional diagnostics for age-related macular degeneration.The essence, advantages and disadvantages, and literature data on the use of such methods asphotostresstest, electrooculography, dark adaptation study, contrast sensitivity function assessment, light and color sensitivity study,electroretinographyand critical flicker fusion frequencyare described.Based on the analysis of literature data, itis shownthat currently, there is a need to searchfor informative and accessible methods

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Gudenas, Brian, Bernhard Englinger, Anthony P. Y. Liu, et al. "ETMR-14. THE SINGLE-CELL LANDSCAPE OF PINEOBLASTOMA IDENTIFIES AN ONCOGENIC PHOTORECEPTOR PROGRAM AS A TUMORIGENIC VULNERABILITY UNIFYING DISTINCT EMBRYONAL CNS TUMOR ENTITIES." Neuro-Oncology 26, Supplement_4 (2024): 0. http://dx.doi.org/10.1093/neuonc/noae064.184.

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Abstract BACKGROUND Pineoblastoma (PB) is a rare and aggressive childhood brain tumor with highly variable outcomes. PB is diagnostically characterized by expression of the photoreceptor identity transcription factor CRX, while tumors can be further classified into molecular subgroups (PB-miRNA1, PB-miRNA2, PB-MYC/FOXR2, and PB-RB1), each marked by unique clinico-molecular features. However, developmental origins of PB subgroup heterogeneity and mechanisms governing malignancy remain unknown. METHODS We assembled a single-nucleus RNA-sequencing cohort (n=25) of primary PB tumors, including cas

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Ong, Janice X., Roya Zandi, and Amani A. Fawzi. "Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption." PLOS ONE 16, no. 11 (2021): e0259811. http://dx.doi.org/10.1371/journal.pone.0259811.

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Purpose To investigate the relationship between disruption in different photoreceptor layers and deep capillary plexus (DCP) telangiectasias in eyes with macular telangiectasia type 2 (MacTel). Methods 35 eyes (21 patients) with MacTel imaged with optical coherence tomography angiography (OCTA) were included. Circumscribed areas of DCP telangiectasia were traced from OCTA slabs and the corresponding spectral-domain OCT (SD-OCT) slabs were used to visualize the photoreceptor layer interdigitation zone (IZ) and ellipsoid zone (EZ). IZ attenuation, IZ loss, and EZ loss were graded by reviewing en

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Khoshnood, Mehdi Mard, Mohammad Zareie, Ali Amiri, Ali Zarenezhad, Elham Zarenezhad, and Arash Esfandiari. "The protective effects of erythropoietin on photoreceptor damage by formaldehyde." Nepalese Journal of Ophthalmology 8, no. 1 (2016): 10–17. http://dx.doi.org/10.3126/nepjoph.v8i1.16151.

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Introduction: The photoreceptor layer of retina has important role for sight. The previous study showed that accidental formaldehyde injection caused ischemia and damage in the retina. On the other hand the erythropoietin prevents neuronal injury of ischemic damage. Objectives: The aim of this study was to survey the effect of erythropoietin on retro bulbar formaldehyde injected photoreceptor layer of rat retina. Materials and methods: 30 adult rats were used and divided into three groups: 1- control group, 2- formaldehyde group (1 ml retro bulbar injected by 10% formaldehyde solution), 3- ery

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Dong, Yujie, Jie Yan, Wenrong Xu, François Paquet-Durand, Zhulin Hu, and Kangwei Jiao. "HDAC inhibition delays photoreceptor loss in Pde6b mutant mice of retinitis pigmentosa: insights from scRNA-seq and CUT&Tag." PeerJ 11 (July 12, 2023): e15659. http://dx.doi.org/10.7717/peerj.15659.

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Purpose This research aimed to ascertain the neuroprotective effect of histone deacetylase (HDAC) inhibition on retinal photoreceptors in Pde6brd1 mice, a model of retinitis pigmentosa (RP). Methods Single-cell RNA-sequencing (scRNA-seq) explored HDAC and poly (ADP-ribose) polymerase (PARP)-related gene expression in both Pde6b-mutant rd1 and wild-type (WT) mice. The CUT&Tag method was employed to examine the functions of HDAC in rd1 mice. Organotypic retinal explant cultures from WT and rd1 mice were exposed to the HDAC inhibitor SAHA (suberoylanilide hydroxamic acid) postnatally, from da

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Hassan, Muhammad, Adithi D. Chakravarthy, Mahadevan Subramaniam, et al. "Correction of perceived visual distortions using a software application and correlation to age-related macular degeneration." Therapeutic Advances in Ophthalmology 12 (January 2020): 251584142091778. http://dx.doi.org/10.1177/2515841420917783.

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Purpose: To investigate the use of software-generated corrections in neutralizing perceived distortions in age-related macular degeneration. Methods: A tablet-based application was utilized to elicit distortions. Five subjects (seven eyes: neovascular age-related macular degeneration and three eyes: non-neovascular age-related macular degeneration) traced the reference lines, and their distortion traces were recorded. To counter distortion, a software-generated trace was re-traced by subjects to produce a corrected trace. Final traces were superimposed on optical coherence tomography images an

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Yang, Grace S., Michael Schmidt, Ziying Yan, et al. "Virus-Mediated Transduction of Murine Retina with Adeno-Associated Virus: Effects of Viral Capsid and Genome Size." Journal of Virology 76, no. 15 (2002): 7651–60. http://dx.doi.org/10.1128/jvi.76.15.7651-7660.2002.

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ABSTRACT Gene therapy vectors based on adeno-associated viruses (AAVs) show promise for the treatment of retinal degenerative diseases. In prior work, subretinal injections of AAV2, AAV5, and AAV2 pseudotyped with AAV5 capsids (AAV2/5) showed variable retinal pigmented epithelium (RPE) and photoreceptor cell transduction, while AAV2/1 predominantly transduced the RPE. To more thoroughly compare the efficiencies of gene transfer of AAV2, AAV3, AAV5, and AAV6, we quantified, using stereological methods, the kinetics and efficiency of AAV transduction to mouse photoreceptor cells. We observed per

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Gao, Sha, Na Li, Yanuo Wang, Yisheng Zhong, and Xi Shen. "Blockade of Adenosine A2A Receptor Protects Photoreceptors after Retinal Detachment by Inhibiting Inflammation and Oxidative Stress." Oxidative Medicine and Cellular Longevity 2020 (July 3, 2020): 1–12. http://dx.doi.org/10.1155/2020/7649080.

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Purpose. Adenosine A2A receptor (A2AR) signaling is neuroprotective in some retinal damage models, but its role in neuronal survival during retinal detachment (RD) is unclear. We tested the hypothesis that A2AR antagonist ZM241385 would prevent photoreceptor apoptosis by inhibiting retinal inflammation and oxidative stress after RD. Methods. The A2AR antagonist ZM241385 was delivered daily to C57BL/6J mice for three days at a dose (3 mg/kg, i.p.) starting 2 hours prior to creating RD. A2AR expression, microglia proliferation and reactivity, glial fibrillary acidic protein (GFAP) accumulation,

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Peng, Zhi-Yu, Kang Xue, Akrit Sodhi, Xiao-Feng Ye, Hui Ren, and Jiang Qian. "Optical coherence tomography enhanced depth imaging of chorioretinal folds in patients with orbital tumors." International Journal of Ophthalmology 16, no. 2 (2023): 233–37. http://dx.doi.org/10.18240/ijo.2023.02.09.

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AIM: To characterize spectral-domain optical coherence tomography (SD-OCT) features of chorioretinal folds in orbital mass imaged using enhanced depth imaging (EDI). METHODS: Prospective observational case-control study was conducted in 20 eyes of 20 patients, the uninvolved eye served as a control. All the patients underwent clinical fundus photography, computed tomography, EDI SD-OCT imaging before and after surgery. Two patients with cavernous hemangiomas underwent intratumoral injection of bleomycin A5; the remaining patients underwent tumor excision. Patients were followed 1 to 14mo follo

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Muhammad Ichsan, Andi. "Visual acuity and contrast sensitivity outcomes based on photoreceptor layer after retinal reattachment surgery." Edorium Journal of Ophthalmology 3, no. 2 (2019): 1–8. http://dx.doi.org/10.5348/100002o02ai2019oa.

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Aims: To evaluate correlation between photoreceptor layer thickness with visual acuity and contrast sensitivity in primary retinal reattachment after vitrectomy. Methods: Twenty seven eyes of 27 patients (mean age 45.6±12.7 years) with successfully retinal reattached were analyzed. Snellen chart visual acuity (VA) to evaluate best-corrected visual acuity (BCVA) converted to the logarithm of the minimum angle of resolution scale (logMAR) and contrast sensitivity in photopic and mesopic illumination using Lea Symbol Flip Chart, funduscopy examination and High Definition Optical Coherence Tomogra

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Fan, Ning, Nina Huang, Dennis Shun Chiu Lam, and Christopher Kai-shun Leung. "Measurement of Photoreceptor Layer in Glaucoma: A Spectral-Domain Optical Coherence Tomography Study." Journal of Ophthalmology 2011 (2011): 1–5. http://dx.doi.org/10.1155/2011/264803.

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Objective.To measure and compare photoreceptor layer thickness between normal and glaucomatous eyes using spectral-domain optical coherence tomography (OCT).Methods. Thirty-eight healthy normal volunteers and 47 glaucoma patients were included in the analysis. One eye from each participant was randomly selected for macula imaging by a spectral-domain OCT (3D OCT-1000, Topcon, Tokyo, Japan). The foveal and parafoveal (1.5 mm from the fovea) outer nuclear layer (ONL) and inner and outer segments (IS+OS) layer thicknesses were measured by a single masked observer. The measurements were repeated 3

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Hood, Donald C., and David G. Birch. "Assessing abnormal rod photoreceptor activity with the a-wave of the electroretinogram: Applications and methods." Documenta Ophthalmologica 92, no. 4 (1996): 253–67. http://dx.doi.org/10.1007/bf02584080.

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Häder, Donat-P., and Michael Lebert. "Analysis of photoreceptor proteins of microorganisms by gradient gel electrophoresis and other biochemical separation methods." Electrophoresis 15, no. 1 (1994): 1051–61. http://dx.doi.org/10.1002/elps.11501501157.

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Tsai, Tina I., Jenny Atorf, Maureen Neitz, Jay Neitz, and Jan Kremers. "Rod- and cone-driven responses in mice expressing human L-cone pigment." Journal of Neurophysiology 114, no. 4 (2015): 2230–41. http://dx.doi.org/10.1152/jn.00188.2015.

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The mouse is commonly used for studying retinal processing, primarily because it is amenable to genetic manipulation. To accurately study photoreceptor driven signals in the healthy and diseased retina, it is of great importance to isolate the responses of single photoreceptor types. This is not easily achieved in mice because of the strong overlap of rod and M-cone absorption spectra (i.e., maxima at 498 and 508 nm, respectively). With a newly developed mouse model ( Opn1lwLIAIS) expressing a variant of the human L-cone pigment (561 nm) instead of the mouse M-opsin, the absorption spectra are

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Kitahata, Shohei, Kiyoko Gocho, Naohiro Motozawa, et al. "Evaluation of photoreceptor features in retinitis pigmentosa with cystoid macular edema by using an adaptive optics fundus camera." PLOS ONE 19, no. 1 (2024): e0296493. http://dx.doi.org/10.1371/journal.pone.0296493.

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Objective Cystoid macular edema (CME) in retinitis pigmentosa (RP) is an important complication causing visual dysfunction. We investigated the effect of CME on photoreceptors in RP patients with previous or current CME, using an adaptive optics (AO) fundus camera. Methods We retrospectively observed the CME and ellipsoid zone (EZ) length (average of horizontal and vertical sections) by optical coherence tomography. The density and regularity of the arrangement of photoreceptor cells (Voronoi analysis) were examined at four points around 1.5° from superior to inferior and temporal to nasal. We

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Gofas-Salas, Elena, Daniel M. W. Lee, Christophe Rondeau, et al. "Comparison between Two Adaptive Optics Methods for Imaging of Individual Retinal Pigmented Epithelial Cells." Diagnostics 14, no. 7 (2024): 768. http://dx.doi.org/10.3390/diagnostics14070768.

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The Retinal Pigment Epithelium (RPE) plays a prominent role in diseases such as age-related macular degeneration, but imaging individual RPE cells is challenging due to their high absorption and low autofluorescence emission. The RPE lies beneath the highly reflective photoreceptor layer (PR) and contains absorptive pigments, preventing direct backscattered light detection when the PR layer is intact. Here, we used near-infrared autofluorescence adaptive optics scanning laser ophthalmoscopy (NIRAF AOSLO) and transscleral flood imaging (TFI) in the same healthy eyes to cross-validate these appr

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Iannetti, Ludovico, Paolo Tortorella, Enzo D’Ambrosio, Rossela Spena, Roberta Zito, and Magda Gharbiya. "Epiretinal Membranes in Patients with Uveitis: Morphological and Functional Analysis with Spectral Domain Optical Coherence Tomography." BioMed Research International 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/284821.

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Purpose. To correlate the uveitic epiretinal membrane (ERM) features using spectral-domain optical coherence tomography (SD-OCT) with visual acuity (VA).Methods. Forty-one eyes of 32 patients were included in this retrospective study. SD-OCT was performed in all patients and data were collected at the time of ERM diagnosis and at the final visit. Both best corrected visual acuity (BCVA) and ERM thickness were correlated with the morphological and clinical features.Results. Final BCVA was positively correlated with male sex and the focal pattern of ERM attachment and negatively correlated with

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Rakesh and Puru Naik Dr. "A study on automated unsupervised identification of cone photoreceptor cells in adaptive optics scanning laser ophthalmoscope images." International Journal of Advance Research in Multidisciplinary 1, no. 1 (2023): 729–37. https://doi.org/10.5281/zenodo.13897058.

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Precise and effective identification of cone photoreceptor cells is essential for comprehending retinal structure and identifying vision-related disorders. Adaptive optics scanning laser ophthalmoscopy (AOSLO) enables the capture of detailed images of the retina, allowing for the visualization of individual photoreceptor cells. Nevertheless, the process of manually identifying these cells is laborious and susceptible to mistakes. This paper presents a novel approach for automatically and without human supervision identifying cone photoreceptor cells in AOSLO pictures. The system utilizes unsup

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Cheng, Hongling, Zhiyang Lin, Kuangching Lin, et al. "ASSOCIATION BETWEEN OBESITY AND ALTERATIONS IN PHOTORECEPTOR–RETINAL PIGMENT EPITHELIUM–CHORIOCAPILLARIS COMPLEX IN HEALTHY EYES." Retina 45, no. 3 (2025): 555–64. https://doi.org/10.1097/iae.0000000000004338.

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Purpose: To investigate the effect of obesity on alterations in the photoreceptor–retinal pigment epithelium (RPE)–choriocapillaris complex. Methods: Two hundred and twenty participants with varying body mass index were enrolled and categorized into three groups: normal weight, overweight, and obese. Retinal and choroidal images were obtained using swept-source optical coherence tomography. Automatic segmentation was used for image analysis, evaluating retina thickness parameters such as retinal nerve fiber layer, ganglion cell layer and inner plexiform layer, inner nuclear layer, outer plexif

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Schultz, Zachary D. "Raman Spectroscopic Imaging of Cholesterol and Docosahexaenoic Acid Distribution in the Retinal Rod Outer Segment." Australian Journal of Chemistry 64, no. 5 (2011): 611. http://dx.doi.org/10.1071/ch11019.

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Raman vibrational spectroscopic imaging was performed on retinal rod cells isolated from bullfrogs (Rana catesbeiana). The Raman spectra enable determination of the lipid and protein rich rod outer segment (ROS) from the nucleus and inner segment of the cell. Peak fitting analysis of spectra obtained from individual rod photoreceptor cells show characteristic vibrational modes that can be associated with cholesterol and docosahexaenoic acid-containing lipids. These results provide direct observations of biomolecular gradients in the rod photoreceptor cells, which, thus far, have been based on

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Burgess, Helen, Muneer Rizvydeen, Fumitaka Kikyo, et al. "0212 Habitual Heavy Alcohol Drinking in Healthy Adults is Associated With Reduced Circadian Photoreceptor Responsivity to Light." Sleep 45, Supplement_1 (2022): A96—A97. http://dx.doi.org/10.1093/sleep/zsac079.210.

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Abstract Introduction Habitual alcohol consumption and circadian timing are interconnected. Numerous studies have reported that heavy alcohol use is associated with eveningness. Only two studies have assessed the dim light melatonin onset (DLMO) in the context of habitual alcohol use, and both reported a shorter DLMO-midsleep interval was associated with heavier alcohol consumption. A gap in this research is the potential impact of alcohol use on the primary circadian photoreceptor, the intrinsically photosensitive retinal ganglion cells (ipRGCs), which influence circadian timing. This study a

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Jatoi, A. "Association between integrity of foveal photoreceptors and ultimate visual outcome in neovascular age-related macular degeneration." Russian Annals of Ophthalmology 141, no. 1 (2025): 32. https://doi.org/10.17116/oftalma202514101132.

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Purpose. This study investigates the clinical features and outcome dimensions of neovascular age-related macular degeneration (nAMD). Material and methods. This retrospective study analyzed 80 subjects diagnosed with nAMD. The patients received successful treatment through intravitreal administration of anti-vascular endothelial growth factor (anti-VEGF) agents. The subjects were classified into three groups based on the final integrity of their inner segment/outer segment (IS/OS) layer of the retina, assessed using spectral-domain optical coherence tomography (SD-OCT). This classification hel

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Nakazawa, Mitsuru, Aiko Hara, and Sei-ichi Ishiguro. "Optical Coherence Tomography of Animal Models of Retinitis Pigmentosa: From Animal Studies to Clinical Applications." BioMed Research International 2019 (October 30, 2019): 1–16. http://dx.doi.org/10.1155/2019/8276140.

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Purpose. The aim of this study was to understand the relationship between the findings of spectral-domain optical coherence tomography (SD-OCT) of previously reported animal models of retinitis pigmentosa (RP) associated with known genetic mutations and their background structural and functional changes. Methods. We reviewed previous publications reporting the SD-OCT findings of animal models of RP and summarized the characteristic findings of SD-OCT in nine different animal models (RCS–/–, RHO P23H, RHO S334ter, RHO–/–, Rpe65–/–, rp12, Pde6β–/– (rd1 and rd10), and Arr1–/–) of human RP. Result

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Tao, Ye, Tao Chen, Zhongyu Liu, et al. "Integrating Topographic Measures to Explore the Protective Effects of Peonidin Against the N-Methyl-N-Nitrosourea Induced Photoreceptor Degeneration." Cellular Physiology and Biochemistry 38, no. 3 (2016): 893–908. http://dx.doi.org/10.1159/000443043.

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Background/Aims: The pathphysiological properties of N-Methyl -N -nitrosourea (MNU) induced photoreceptor degeneration are similar to the hereditary retinitis pigmentosa (RP). The present study sought to explore the beneficial effects of the peonidin, a common aglycone form of anthocyanin, on the MNU induced photoreceptor degeneration via topographic measurements. Methods: The MNU administrated mouse received peonidin or vehicle injections, and then they were examined by electroretinography (ERG), multi electrode array (MEA), histological and immunohistochemistry studies. Results: The protecti

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Krauss, Ulrich, Bui Quang Minh, Aba Losi, et al. "Distribution and Phylogeny of Light-Oxygen-Voltage-Blue-Light-Signaling Proteins in the Three Kingdoms of Life." Journal of Bacteriology 191, no. 23 (2009): 7234–42. http://dx.doi.org/10.1128/jb.00923-09.

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ABSTRACT Plants and fungi respond to environmental light stimuli via the action of different photoreceptor modules. One such class, responding to the blue region of light, is constituted by photoreceptors containing so-called light-oxygen-voltage (LOV) domains as sensor modules. Four major LOV families are currently identified in eukaryotes: (i) the plant phototropins, regulating various physiological effects such as phototropism, chloroplast relocation, and stomatal opening; (ii) the aureochromes, mediating photomorphogenesis in photosynthetic stramenopile algae; (iii) the plant circadian pho

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Tatarnikova, O. N., and L. N. Konovalova. "Solar retinopathy in a 19–year-old man: a clinical case." Modern technologies in ophtalmology, no. 1 (March 28, 2023): 343–46. http://dx.doi.org/10.25276/2312-4911-2023-1-343-346.

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Due to the fact that Buryatia is a sunny region with high activity of UV rays, this pathology can occur quite often. Purpose. To evaluate the effectiveness of nutraceuticals and a complex of water-soluble polypeptide fractions with a molecular weight of no more than 10,000 Da (retinalamine) in the process of restoring photoreceptors and pigment epithelial cells. Material and methods. Observation and examination of one patient with a case of solar retinopathy using Retinalamine and nutraceuticals in the treatment. The patient underwent optical coherence tomography in Retina Map, Cross line, Rad

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Santo, Manuela, and Ivan Conte. "Emerging Lysosomal Functions for Photoreceptor Cell Homeostasis and Survival." Cells 11, no. 1 (2021): 60. http://dx.doi.org/10.3390/cells11010060.

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Lysosomes are membrane-bound cell organelles that respond to nutrient changes and are implicated in cell homeostasis and clearance mechanisms, allowing effective adaptation to specific cellular needs. The relevance of the lysosome has been elucidated in a number of different contexts. Of these, the retina represents an interesting scenario to appreciate the various functions of this organelle in both physiological and pathological conditions. Growing evidence suggests a role for lysosome-related mechanisms in retinal degeneration. Abnormal lysosomal activation or inhibition has dramatic conseq

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Bhatia, Vaibhav, Lourdes Valdés-Sánchez, Daniel Rodriguez-Martinez, and Shom Shankar Bhattacharya. "Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice." F1000Research 7 (August 10, 2018): 1233. http://dx.doi.org/10.12688/f1000research.15579.1.

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Background: Photoreceptors, light-sensing neurons in retina, are central to vision. Photoreceptor cell death (PCD) is observed in most inherited and acquired retinal dystrophies. But the underlying molecular mechanism of PCD is unclear. Photoreceptors are sturdy neurons that survive high oxidative and phototoxic stress, which are known threats to genome stability. Unexpectedly, DNA damage response in mice photoreceptors is compromised; mainly due to loss of crucial DNA repair proteins, ATM and 53BP1. We tried to understand the molecular function of ATM and 53BP1 in response to oxidative stress

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Valdés-Sánchez, Lourdes, Seyed Mohamadmehdi Moshtaghion, Estefanía Caballano-Infantes, et al. "Synthesis and Evaluation of Glucosyl-, Acyl- and Silyl- Resveratrol Derivatives as Retinoprotective Agents: Piceid Octanoate Notably Delays Photoreceptor Degeneration in a Retinitis Pigmentosa Mouse Model." Pharmaceuticals 17, no. 11 (2024): 1482. http://dx.doi.org/10.3390/ph17111482.

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Background: Retinitis pigmentosa (RP), the leading cause of inherited blindness in adults, is marked by the progressive degeneration of rod photoreceptors in the retina. While gene therapy has shown promise in treating RP in patients with specific mutations, no effective therapies currently exist for the majority of patients with diverse genetic backgrounds. Additionally, no intervention can yet prevent or delay photoreceptor loss across the broader RP patient population. Resveratrol (RES), a naturally occurring polyphenol, has shown cytoprotective effects in various neurodegenerative disease

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Cantó, Antolín, Javier Martínez-González, Inmaculada Almansa, et al. "Time-Course Changes in Oxidative Stress and Inflammation in the Retinas of rds Mice: A Retinitis Pigmentosa Model." Antioxidants 11, no. 10 (2022): 1950. http://dx.doi.org/10.3390/antiox11101950.

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(1) Background: Retinitis pigmentosa (RP) is characterized by progressive photoreceptor death. A Prph2Rd2 or an rds mouse is an RP model that closely reflects human RP. The objective of this study was to investigate the relationship of rod and cone death with oxidative stress and inflammation in rds mice. (2) Methods: The retinas of control and rds mice on postnatal days (PN) 11, 17, 21, 28, 35, and 42 were used. Oxidative damage to macromolecules, glutathione (GSH and GSSG), GSH synthesis enzymes, glial fibrillar acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba1), and cl

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Tao, Ye, Lei Ding, Anhui Yao та ін. "Intravitreous Delivery of Αb-Crystallin Ameliorates N-Methyl-N-Nitrosourea Induced Photoreceptor Degeneration in Mice: An in vivo and ex vivo Study". Cellular Physiology and Biochemistry 48, № 5 (2018): 2147–60. http://dx.doi.org/10.1159/000492557.

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Background/Aims: αB –crystallin (αBC) belongs to the family of small heat shock proteins that are necessary for maintaining oxygen homeostasis. This study was designed to explore the possible effects of αBC on N-methyl- N-nitrosourea (MNU) induced retinal degeneration and the underlying mechanisms. Methods: The αBC was injected into the vitreous bodies of MNU administered mice. The retinal morphology and visual function of experimental animals were analyzed by electroretinography (ERG), Spectral domain optical coherence tomography (SD-OCT), fundus photographs, optokinetic testing and immunohis

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Xia, Zheren, Hao Chen, and Suilian Zheng. "Alterations of Retinal Pigment Epithelium–Photoreceptor Complex in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy: A Cross-Sectional Study." Journal of Diabetes Research 2020 (March 6, 2020): 1–6. http://dx.doi.org/10.1155/2020/9232157.

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Aim. A cross-sectional study was performed to examine the alterations of the retinal pigment epithelium– (RPE–) photoreceptor complex layer in type 2 diabetes mellitus (DM) without diabetic retinopathy (DR), using spectral-domain optical coherence tomography (SD-OCT). Methods. Patients with type 2 DM without DR and healthy controls without DM were recruited. All participants underwent examinations including SD-OCT. The thickness measurements of the retinal neural layers were calculated after automatic segmentation. An independent-sample t-test was used to compare the means of the thickness of

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Sladen, Paul E., Arifa Naeem, Toyin Adefila-Ideozu, et al. "AAV-RPGR Gene Therapy Rescues Opsin Mislocalisation in a Human Retinal Organoid Model of RPGR-Associated X-Linked Retinitis Pigmentosa." International Journal of Molecular Sciences 25, no. 3 (2024): 1839. http://dx.doi.org/10.3390/ijms25031839.

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Variants within the Retinitis Pigmentosa GTPase regulator (RPGR) gene are the predominant cause of X-Linked Retinitis Pigmentosa (XLRP), a common and severe form of inherited retinal disease. XLRP is characterised by the progressive degeneration and loss of photoreceptors, leading to visual loss and, ultimately, bilateral blindness. Unfortunately, there are no effective approved treatments for RPGR-associated XLRP. We sought to investigate the efficacy of RPGRORF15 gene supplementation using a clinically relevant construct in human RPGR-deficient retinal organoids (ROs). Isogenic RPGR knockout

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Yamauchi, Kodai, Reiko Tanabu, Natsuki Monai, et al. "The Spectral-Domain Optical Coherence Tomography Findings Associated with the Morphological and Electrophysiological Changes in a Rat Model of Retinal Degeneration, Rhodopsin S334ter-4 Rats." BioMed Research International 2018 (November 15, 2018): 1–10. http://dx.doi.org/10.1155/2018/5174986.

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Purpose. To characterize the spectral-domain optical coherence tomography (SD-OCT) findings of the rhodopsin S334ter transgenic rats (line 4) in relation to the morphologic and electroretinographic features. Materials and Methods. Rhodopsin S334ter transgenic rats (line 4) were employed as a model of retinal degeneration. The Sprague-Dawley (SD) rats were used as a wild-type control. SD-OCT (Micron IV®; Phoenix Research Labs, Pleasanton, CA, USA) was performed on the S334ter rats (line 4) from postnatal days (P) 13−110. The longitudinal changes of the SD-OCT images were analyzed both qualitati

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Yang, Qianqian, Li Zhang, Jinhan Cheng, and Jingan Tong. "Research Progress in TCM Treatment of Retinitis Pigmentosa." Journal of Clinical and Nursing Research 6, no. 3 (2022): 151–56. http://dx.doi.org/10.26689/jcnr.v6i3.3933.

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Retinitis pigmentosa (RP) is a genetic eye disease characterized by primary dystrophic degenerative lesions of photoreceptor cells and retinal pigment epithelium. Although there are many treatment methods, there is still a lack of effective methods to restore visual acuity and visual field. Traditional Chinese medicine ophthalmologists have been conducting extensive clinical research on retinitis pigmentosa for a long time and have achieved significant progress. The paper is a summary of the progress of traditional Chinese medicine in the treatment of retinitis pigmentosa in the last five year

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Schopf, Krystina, Thomas K. Smylla, and Armin Huber. "Immunocytochemical Labeling of Rhabdomeric Proteins inDrosophilaPhotoreceptor Cells Is Compromised by a Light-dependent Technical Artifact." Journal of Histochemistry & Cytochemistry 67, no. 10 (2019): 745–57. http://dx.doi.org/10.1369/0022155419859870.

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Drosophila photoreceptor cells are employed as a model system for studying membrane protein transport. Phototransduction proteins like rhodopsin and the light-activated TRPL ion channel are transported within the photoreceptor cell, and they change their subcellular distribution in a light-dependent way. Investigating the transport mechanisms for rhodopsin and ion channels requires accurate histochemical methods for protein localization. By using immunocytochemistry the light-triggered translocation of TRPL has been described as a two-stage process. In stage 1, TRPL accumulates at the rhabdome

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Ruppert, Misty, John Pyun, K. V. Chalam, and David Sierpina. "Multimodal Imaging Characteristics of ADRP in a Family with p.Thr58Arg Substituted RHO Mutation." Case Reports in Genetics 2020 (December 2, 2020): 1–9. http://dx.doi.org/10.1155/2020/8860863.

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Background. Autosomal dominant retinitis pigmentosa (adRP) is a rare cause of progressive visual impairment in young patients and is frequently a result of RHO gene mutations. p.Thr58Arg rhodopsin mutation leads to misfolding of rhodopsin, subsequent accumulation in the endoplasmic reticulum, and leads to consecutive atrophy of photoreceptor cells through apoptosis. Materials and Methods. We describe multimodal imaging findings in a 58-year-old female with adRP due to a c.173 C > G, p.Thr58Arg rhodopsin mutation (confirmed on genotyping), including ultra-wide-field fundus autofluorescence (

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Xu, Wei, Xiao-Ying Yang, Xiao-Yuan Cui, Jian Guo та Guo-Xing Xu. "Impaired pericyte-Müller glia interaction via PDGFRβ suppression aggravates photoreceptor loss in a rodent model of light-induced retinal injury". International Journal of Ophthalmology 17, № 10 (2024): 1800–1808. http://dx.doi.org/10.18240/ijo.2024.10.05.

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AIM: To investigate the involvement of pericyte-Müller glia interaction in retinal damage repair and assess the influence of suppressing the platelet-derived growth factor receptor β (PDGFRβ) signaling pathway in retinal pericytes on photoreceptor loss and Müller glial response. METHODS: Sprague-Dawley rats were exposed to intense light to induce retinal injury. Neutralizing antibody against PDGFRβ were deployed to block the signaling pathway in retinal pericytes through intravitreal injection. Retinal histology and Müller glial reaction were assessed following light injury. In vitro, normal a

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Zhou, Yumei, Weiwei Xu, Anqi Liu, et al. "Protective Effect of Salvianolic Acid A against N-Methyl-N-Nitrosourea-Induced Retinal Degeneration." Evidence-Based Complementary and Alternative Medicine 2022 (May 27, 2022): 1–10. http://dx.doi.org/10.1155/2022/1219789.

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Objective. Retinal degeneration (RD) is a serious, irreversible, and blinding eye disease, which seriously affects the visual function and quality of life of patients. At present, there is no effective method to treat RD. The final outcome of its development is photoreceptor cell oxidation and apoptosis. Therefore, looking for safe, convenient, and effective antioxidant therapy is still the key research field of Rd. In this study, the mice model of RD was induced by N-methyl-N-nitrosourea (MNU) in vivo to explore the therapeutic effect and mechanism of salvianolic acids (Sal A) on RD. In vitro

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Zhmurko, V. V., O. O. Avksentieva, and Y. D. Batuieva. "Photomorphogenesis and content of carbohydrates in the axial organs of field pean seedlings under the influence of selective light." 47, no. 47 (September 23, 2022): 27–39. http://dx.doi.org/10.26565/2075-3810-2022-47-03.

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Background: Light is a multifaceted exogenous factor that plays an important role in plant growth and development. The spectral composition of light is determinative for the regulation of photomorphogenetic processes in plants. Nowadays plants have several groups of photoreceptors that include receptors of red (RL) and far red light (FRL) — phytochromes; receptors of UV-A, blue (BL) and green (GL) light — cryptochromes, phototropins, proteins of the ZEITLUPE family, as well as the UV-B receptor — UVR8 protein. One of the possible mechanisms that realize an activation of photoreceptor systems i

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Desmettre, Thomas, Martin A. Mainster, and Gerardo Ledesma-Gil. "Half-Fluence, Half-Dose Photodynamic Therapy: Less Direct Damage but More Inflammation?" Pharmaceuticals 16, no. 4 (2023): 494. http://dx.doi.org/10.3390/ph16040494.

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Objective: To present clinical findings and multimodal imaging of three patients who developed bacillary layer detachments (BALADs) shortly after half-fluence, half-dose (HFHD) verteporfin photodynamic therapy (PDT). Methods: Retrospective observational case series. Three patients were treated with HFHD-PDT for (1) macular neovascularisation five years after resolved central serous chorioretinopathy (CSC), (2) persistent serous retinal detachment (SRD) from chronic CSC, and (3) neovascular age-related macular degeneration with persistent SRD despite intravitreal anti-VEGF therapy. Results: Eac

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Zhou, Dan, Florentina Teofilovici, Yuan Liu, et al. "Associating retinal drug exposure and retention with the ocular toxicity profiles of Hsp90 inhibitors." Journal of Clinical Oncology 30, no. 15_suppl (2012): 3086. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.3086.

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3086 Background: In clinical trials certain Hsp90 inhibitors, including AUY922, SNX-5422, and 17-DMAG have caused visual symptoms suggesting retinal dysfunction; others, including ganetespib and 17-AAG, have not. Previous animal toxicology experiments have suggested that retinal changes may be linked to photoreceptor degeneration or cell death. Here histopathologic changes and/or exposure profiles of Hsp90 inhibitors with or without clinical reports of ocular toxicity were evaluated to understand the observed differences in toxicity profile between agents in this class. Methods: We reviewed vi

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