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Journal articles on the topic 'Methyl derivative'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Khalifa, Nagy M., Ahmed M. Naglah, Mohamed A. Al-Omara, and Abd El-Galil E. Amr. "Synthesis and Reactions of New Chiral Linear Dipeptide Candidates Using Nalidixic Acid as Starting Material." Zeitschrift für Naturforschung B 69, no. 6 (2014): 728–36. http://dx.doi.org/10.5560/znb.2014-4031.

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A series of dipeptide heterocyclic derivatives 4-15 were synthesized using methyl 2-{[(1-ethyl- 7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)carbonyl]amino}-3-ethylbutanoate (3) as starting material. Treatment of 3 with L-phenylalanine methyl ester hydrochloride afforded the corresponding dipeptide methyl ester derivative 4, which was treated with hydrazine hydrate to afford the dipeptide acid hydrazide 5. Compound 5 was coupled with aldehyde and acetophenone derivatives to afford the corresponding Schiff bases 6a-f. The hydrazide derivative 5 was reacted with ethyl acetoacetate or acetone

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2

Mistry, Rakesh N., and K. R. Desai. "Studies on Synthesis of Some Novel Heterocyclic Azlactone Derivatives and Imidazolinone Derivatives and their Antimicrobial Activity." E-Journal of Chemistry 2, no. 1 (2005): 42–51. http://dx.doi.org/10.1155/2005/542938.

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p- Methyl benzoic acid on reaction with phosphorus pentachloride gives p - methyl benzoyl chloride derivative which on condensation with glycine gives p - methyl benzoyl glycine derivative. Now, this p - methyl benzoyl glycine derivative on condensation with various substituted aldehydes gives corresponding substituted 4 - [aryl methylidine] - 2 - [p - methyl phenyl] - oxazole - 5 - one derivatives [1(a-j)]. Further, these derivatives [1(a-j)] on condensation with 4 , 4’ - diamino diphenyl sulphone gives corresponding substituted imidazolinone - dibenzsulphone derivatives [2(a-j)], on condensa

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3

Naseer Ali, Dina, Kawther Adeeb Hussein, Marwa Faeq, Yudhisman Imran, and Waled Abdo Ahmed. "Molecular Docking, Synthesis of New Schiff base Derivatives, and Study of their Biological Activity." Al-Nahrain Journal of Science 27, no. 5 (2024): 25–34. https://doi.org/10.22401/anjs.27.5.04.

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The Schiff bases (E1-E3) are generated by reacting azo derivative (A) with different amine derivatives. The Schiff bases (E1-E3) are obtained via the reaction between azo derivative with 4-methylbenzaldehyde, 4-ethyl-benzaldehyde, and 4-hydroxy-benzaldehyde. The Schiff base E1 namely:2-[(4-methylphenyl)diazenyl]-4-{(E)-[(4-methylphenyl)imino]-methyl}phenol; E2:4-{(E)-[(4-ethylphenyl)imino]-methyl}-2-[(4-methyl-phenyl)diazenyl]phenol; E3:4-{(E)-[(4-hydroxyphenyl)imino]methyl}-2-[(4-methylphenyl)diazenyl]phenol. All synthesized derivatives are characterized based on physical characteristics and

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4

M.A., METWALLY, Y. YOUSIF M., ISMAIEL A.M., and A. AMER F. "Syntheses of Some Arylsulphonyl Pyrazolines and Pyrazolones as Potential Antipyretic Analgesic Agents." Journal of Indian Chemical Society Vol. 62, Jan 1985 (1985): 54–56. https://doi.org/10.5281/zenodo.6302358.

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University of Mansoura, Mansoura, Egypt <em>Manuscript received 21 February 1984, accepted 15 August 1984</em> Treatment of 3-methyl or 3-phenyl-2-pyrazolin-5-ones (1a, b) with <em>p</em>-acetamido or <em>p</em>-methylbenzenesulphonyl chloride afforded the O-sulphonyl derivatives (3a-d). The N-sulphonyl derivative (6) and N-methyl derivative (8) were also prepared. The 3- anilino derivatives (10a-d) and 3,5-dimethylpyrazoline derivative (13) were prepared. The ir spectral data of the synthesised compounds are discussed.

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5

Kaválek, Jaromír, Josef Jirman, and Vojeslav Štěrba. "Kinetics and mechanism of rearrangement and methanolysis of acylphenylthioureas." Collection of Czechoslovak Chemical Communications 50, no. 3 (1985): 766–78. http://dx.doi.org/10.1135/cccc19850766.

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S-Acyl-1-phenylthioureas and their 3-methyl derivatives are rearranged to 1-acyl derivatives of thiourea in methanolic solution. The rearrangement of the 1-acyl-1-phenyl derivative to the thermodynamically more stable 3-acyl derivative is subject to specific base catalysis. The rearrangement of acetyl group is about 2 orders of magnitude slower than that of benzoyl group. 1-Acetyl-l-phenylthiourea undergoes base-catalyzed methanolysis (giving phenylthiourea and methyl acetate) instead of the rearrangement. The methanolysis rates of l-acyl-3-phenylthioureas and their N-methyl derivatives have b

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6

Kaválek, Jaromír, Josef Jirman, Vladimír Macháček, and Vojeslav Štěrba. "An anomalous effect of methyl group on acidity of acylthioureas." Collection of Czechoslovak Chemical Communications 52, no. 8 (1987): 1992–98. http://dx.doi.org/10.1135/cccc19871992.

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Dissociation constants and methanolysis rate constants have been measured of 1-acetyl- and 1-benzoylthioureas and their N-methyl derivatives. Replacement of hydrogen atom at N(1) (next to the acyl group) by methyl group increases the acidity of the benzoyl derivative by one order, that of the acetyl derivative by as much as two orders of magnitude. Replacement of both hydrogens at N(3) by methyl groups lowers the methanolysis rate constant by more than two orders, whereas the replacement of hydrogen atom at N(1) by methyl group increases the methanolysis rate by the factor of 30.

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7

Okopi, S. O., and L. M. Affiku. "Synthesis and Olfactory Characteristics of Hydroxyether Derivatives of Methyl Eugenol." Journal of Applied Sciences and Environmental Management 24, no. 9 (2020): 1503–7. http://dx.doi.org/10.4314/jasem.v24i9.3.

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Methyl eugenol is a naturally occurring substance found in the essential oils of several plant species. It is a cheap and abundant material with a rather limited interest as perfuming ingredient. This research investigated the structure-odour relationship of methyl eugenol and its derivatives, focusing on the chemical transformation of the double bond to hydroxyether derivatives in a controlled manner. Two derivatives 2-(4-ethyl- 3-methoxybenzyl)oxirane (68.8% yield) and 1-(3,4-dimethoxyphenyl)-3-ethoxypropan-2-ol (63.58% yield), were synthesized from methyl eugenol. This research found that t

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8

Mooser, Andrê E., and Herbert Koch. "Confirmatory Method for Sulfonamide Residues in Animal Tissues by Gas Chromatography and Pulsed Positive Ion-Negative Ion-Chemical Ionization Mass Spectrometry." Journal of AOAC INTERNATIONAL 76, no. 5 (1993): 976–82. http://dx.doi.org/10.1093/jaoac/76.5.976.

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Abstract A confirmatory method has been developed for determination of 13 sulfonamides in edible tissues. The assay involves extraction from a solution resulting from a screening procedure by liquid chromatography and subsequent derivatization. Sulfachloropyridazine (SCP), sulfadiazine (SDA), sulfadimethoxine (SDM), sulfamethazine (SMZ), sulfamerazine (SME), sulfamethoxazole (SMX), sulfamethoxypyridazine (SMP), sulfapyridine (SPR), sulfaquinoxaline (SQX), and sulfathiazole (STA) were detected as the N1-methyl-N4-trifluoroacetyl derivatives, sulfaguanidine (SGU) as the same derivative after cyc

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9

Burgess, VA, та CJ Easton. "Reaction of N-Benzoyl-2-bromoglycine Methyl Ester With Deprotonated Nitroalkanes: Synthesis of β-Nitro and α,β-Dehydro Amino Acid Derivatives". Australian Journal of Chemistry 41, № 7 (1988): 1063. http://dx.doi.org/10.1071/ch9881063.

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N-Benzoyl-2-bromoglycine methyl ester (1) reacted with the alkyl nitronates (2a-e) to give the corresponding β-nitro amino acid derivatives (4a-e). Elimination reactions of (4a-d) afforded the α,β-dehydro amino acid derivatives (5a-d). Treatment of the β- nitrovaline derivative (4b) with tributyltin hydride gave the valine derivative (8). Reduction of the β- nitroalanine derivative (4a) gave the β- aminoalanine derivative (9), characterized by hydrolysis to 2,3- diaminopropionic acid hydrochloride.

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10

Klinot, Jiří, Jarmil Světlý, Eva Klinotová, Miloš Buděšínský та Alois Vystrčil. "Preparation of isomeric 2-methyl-1-oxotriterpenoids of the 18α-oleanane series; Conformation of ring A". Collection of Czechoslovak Chemical Communications 51, № 12 (1986): 2869–78. http://dx.doi.org/10.1135/cccc19862869.

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2β-Methyl-1α-hydroxy (XV) and two isomeric 2-methyl-1-oxo derivatives (XVI and XVII) of 19β,28-epoxy-18α-oleanane were prepared from 19β,28-epoxy-2-methyl-18α-olean-1-en-3-one (XI) via 3β-chloro derivative XIII and unsaturated 1α-hydroxy derivative XIV. Allylic oxidation of 2-methyl-2-ene VI was studied as an alternative approach to compound XIV. Oxidation with selenium dioxide led to diol VII, aldehyde VIII and alcohol IV, oxidation with tert-butyl chromate gave epoxy ketone X. According to 1H NMR and CD data, ring A in the 2β-methyl derivatives XV and XVI exists in a boat conformation. The 2

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11

Avendaño, Carmen, María Teresa Ramos, José Elguero, María Luisa Jimeno, Juana Bellanato, and Feliciana Florencio. "Tautomerism of bis(2-benzothiazolyl)methanes." Canadian Journal of Chemistry 66, no. 6 (1988): 1467–73. http://dx.doi.org/10.1139/v88-236.

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Tautomerism of dibenzothiazolylmethane (1) and its C-methyl derivative (2) has been studied by 1H nuclear magnetic resonance, ultraviolet, and infrared spectroscopy using C,C-dimethyl (3) and N-methyl (4) derivatives as model compounds of the "CH" and "NH" forms, respectively. X-ray diffraction analysis of the "fixed" N-methyl derivative 4 shows that it corresponds to the Z-sE isomer 4b2. The CH tautomers are unstable in solution and they slowly isomerize into a mixture of NH tautomers that depends on the solvent and on the C-substituent (H or CH3).

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12

Rádl, Stanislav, and Viktor Zikán. "Synthesis of 1,2, and 9-methyl derivatives of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity." Collection of Czechoslovak Chemical Communications 52, no. 3 (1987): 788–92. http://dx.doi.org/10.1135/cccc19870788.

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The paper describes syntheses of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ia), its 1-methyl derivative (Ic), 1,9-dimethyl derivative (Ie), 2-methyl derivative (IIa), and 2,9-dimethyl derivative (IIc). Demethylation of these compounds with hydrobromic acid afforded 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ib), its 1-methyl derivative (Id), 1,9-dimethyl derivative (If), 2-methyl derivative (IIb), and 2,9-dimethyl derivative (IId) respectively. 4,9-Dihydro-6-hydroxy-3,9-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (Ig) was prepared by demeth

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13

Bonnier, Catherine, David S. Josey, and Timothy P. Bender. "Aryl-Substituted Boron Subphthalocyanines and their Application in Organic Photovoltaics." Australian Journal of Chemistry 68, no. 11 (2015): 1750. http://dx.doi.org/10.1071/ch15381.

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A family of five axial aryl-substituted boron subphthalocyanine (BsubPc) derivatives bearing a hydrido, methyl, methoxy, phenyl, or fluoro substituent at the para position of the aryl were synthesised from Br-BsubPc and the corresponding aryl Grignard reagent in moderate yields. The physicochemical characterisation of these derivatives gave similar absorption, photoluminescence, and cyclic voltammetry profiles and photoluminescence quantum yields, indicating that the nature of the substituent at the para position does not influence the basic photophysical properties of this generic class of Bs

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14

Krečmerová, Marcela, Hubert Hřebabecký, Milena Masojídková, and Antonín Holý. "2',3'-Dideoxy- and 3'-Azido-2',3'-dideoxynucleosides of 5-Phenyl-2(1H)-pyrimidinone. Preparation of 2',3'-Dideoxypentofuranoses." Collection of Czechoslovak Chemical Communications 61, no. 3 (1996): 478–88. http://dx.doi.org/10.1135/cccc19960478.

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The synthesis of methyl 3-azido-5-benzoyl-2,3-dideoxy-β-D-ribofuranoside (10) from methyl 2-deoxy-D-ribofuranoside (1) and its use for the preparation of 3'-azido-2',3'-dideoxy-β-D-ribofuranosides is described. Reaction of methylglucoside 1 with benzoyl chloride in pyridine afforded 5-O-benzoyl derivative 2, which on oxidation with complex of chromium trioxide, pyridine and acetic anhydride afforded 3-keto derivative 3. This was reduced with sodium borohydride in ethanol to give a mixture of methyl 2-deoxyglycosides of α-D-ribo- (4) and β-D-xylo- (5) configuration. Their mesyl derivatives 6 an

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15

Rádl, Stanislav, Viktor Zikán, and František Šmejkal. "Syntheses of 1, 2, and 9-methyl derivatives of 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity." Collection of Czechoslovak Chemical Communications 50, no. 5 (1985): 1057–63. http://dx.doi.org/10.1135/cccc19851057.

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The paper describes syntheses of 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ia), its 1-methyl derivative (Ib), 2-methyl derivative (IIa), 9-methyl derivative (Ic), 1,9-dimethyl derivative (Id) and 2,9-dimethyl derivative (IIb). Sodium salts of compounds Ia, Ib, Ic and IIa were methylated with methyl iodide in dimethylformamide at room temperature, compounds Id and IIb were demethylated with pyridine hydrochloride. The compounds prepared were tested for antiviral activity in vivo in mice against influenza virus A2-Hongkong and the Encephalomyocarditis virus.

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16

Fraser, Robert R., Corinne Bensimon, Fanzuo Kong, and Xinfu Wu. "An X-ray and conformational study of 5,7-dihydro-1,11-dimethyl-6H-dibenzo[a,c]cyclohepten-6-one and its methyl derivatives." Canadian Journal of Chemistry 71, no. 5 (1993): 685–94. http://dx.doi.org/10.1139/v93-093.

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The crystal structures for the title compound 1 and its α-methyl derivatives 2–4 have been determined. Molecular mechanics calculations of the conformation of minimum energy for 1, 3, and 4 correspond closely to the symmetric structures observed in the crystal. For 2, rotation at the CO—CH2 bond by 24° produced an asymmetric conformation matching that seen in the solid state. The calculated changes in energy as a function of the torsional angle for 1 and 2 were compared with those for cyclohexanone and the axial conformer of the α-methyl derivative. The energy requirements for conformational c

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17

Rádl, Stanislav. "Preparation of 1-Hydroxyxanthen-9(9H)-ones and 1-Hydroxyacridin-9(10H)-ones via Corresponding 3,4-Dihydro-1,9(2H)-diones." Collection of Czechoslovak Chemical Communications 60, no. 12 (1995): 2127–36. http://dx.doi.org/10.1135/cccc19952127.

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Target 10-cyclopropyl-7-fluoro-1-hydroxy-6-(4-methyl-1-piperazinyl)acridin-9(10H)-one (IVc) and 7-fluoro-1-hydroxy-6-(4-methyl-1-piperazinyl)-9H-xanthen-9-one (IVd) were obtained from corresponding difluoro derivatives IVa and IVb, respectively. These intermediates were synthesized via respective 3,4-dihydro-1,9(2H)-diones Va and Vb. Acridine derivative (10-cyclopropyl-6,7-difluoro-3,4-dihydro-1H-acridine-1,9(2H,10H)-dione, Va) was synthesized from 1-cyclopropyl-6,7-difluoroisatoic anhydride (XI) and xanthene derivative (6,7-difluoro-3,4-dihydro-1H-xanthen-1,9(2H)-dione, Vb) from cyclohexenone

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18

Mahyavanshi, Jyotindra, Snehal Lokhandwala, Jayesh Pandya, and Jigar Patel. "Synthesis, Structural Determination, Docking Study and Bioactivity of Novel Thiophene Derivatives." Asian Journal of Chemistry 36, no. 6 (2024): 1321–26. http://dx.doi.org/10.14233/ajchem.2024.31509.

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The present study reveals 4-methyl-3-(propylamino)thiophene-2-carboxylic acid (Articaine acid) as precursor derivative to synthesize novel thiophene compounds to evaluate their biological activity. The synthesized compounds were subjected to comprehensive characterization techniques including mass spectra, NMR and IR spectroscopy, confirming their structural integrity. Their antimicrobial activity was assessed via minimum inhibitory concentration (MIC) assay against selected bacterial strains. The results emphasize the potential therapeutic applications of these thiophene analogues as efficaci

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19

Li, Yawen, Ming-Kuan Chyan, Donald K. Hamlin, Holly Nguyen, Eva Corey, and D. Scott Wilbur. "Oxidation of p-[125I]Iodobenzoic Acid and p-[211At]Astatobenzoic Acid Derivatives and Evaluation In Vivo." International Journal of Molecular Sciences 23, no. 18 (2022): 10655. http://dx.doi.org/10.3390/ijms231810655.

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The alpha particle-emitting radionuclide astatine-211 (211At) is of interest for targeted radiotherapy; however, low in vivo stability of many 211At-labeled cancer-targeting molecules has limited its potential. As an alternative labeling method, we evaluated whether a specific type of astatinated aryl compound that has the At atom in a higher oxidation state might be stable to in vivo deastatination. In the research effort, para-iodobenzoic acid methyl ester and dPEG4-amino acid methyl ester derivatives were prepared as HPLC standards. The corresponding para-stannylbenzoic acid derivatives wer

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20

Lundquist, Knut, Jim Parkås, Magnus Paulsson, and Cyril Heitner. "Reactions of lignin chromophores of the enal and enone type with sulfite." BioResources 2, no. 3 (2007): 334–50. http://dx.doi.org/10.15376/biores.2.4.334-350.

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In NaHSO3-solutions of coniferaldehyde and its methyl ether (models for lignin chromophores of the cinnamaldehyde type) a dynamic equilibrium between the aldehydes and their hydrogen sulfite adducts is set up. A comparatively slow addition of hydrogen sulfite to the double bond leading to 1,3-disulfonic acid derivatives occurs; coniferaldehyde reacts slower than its methyl ether. In Na2SO3-solution both aldehydes are rapidly converted to 1,3-disulfonic acid derivatives. The results suggest that in both NaHSO3-solution and Na2SO3-solution the free cinnamaldehydes and sulfite ion are the reactan

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21

Lundquist, Knut, Jim Parkås, Magnus Paulsson, and Cyril Heitner. "Reactions of lignin chromophores of the enal and enone type with sulfite." BioResources 2, no. 3 (2007): 334–50. http://dx.doi.org/10.15376/biores.2.3.334-350.

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In NaHSO3-solutions of coniferaldehyde and its methyl ether (models for lignin chromophores of the cinnamaldehyde type) a dynamic equilibrium between the aldehydes and their hydrogen sulfite adducts is set up. A comparatively slow addition of hydrogen sulfite to the double bond leading to 1,3-disulfonic acid derivatives occurs; coniferaldehyde reacts slower than its methyl ether. In Na2SO3-solution both aldehydes are rapidly converted to 1,3-disulfonic acid derivatives. The results suggest that in both NaHSO3-solution and Na2SO3-solution the free cinnamaldehydes and sulfite ion are the reactan

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22

Klinot, Jiří, Jarmil Světlý, Eva Klinotová, and Alois Vystrčil. "Preparation of isomeric 2-methyl-3-oxolupane-28-nitriles." Collection of Czechoslovak Chemical Communications 50, no. 12 (1985): 2918–24. http://dx.doi.org/10.1135/cccc19852918.

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2β-Methyl- and 2α-methyl-3-oxo derivatives of lupane-28-nitrile XV and XVI were prapared from betulin-3-acetate (I). The key steps of the synthesis were the condensation of ketone VII with formaldehyde and dimethylamine hydrochloride, conversion of the methylene ketone VIII formed to 3β-acetoxy-2-methylene derivative X and hydrogenation of the exomethylene double bond. Both 2-methyl-3-oxo derivatives, XV and XVI, are approximately equally stable; in their equilibrium mixture 47 ± 3% of the 2β-isomer were found.

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23

Glisin, Djordje, Olga Jovanovic, Gordana Stojanovic та ін. "Synthesis of methyl 3,4-anhydro-6-bromo-2-o-tert-butyldimethylsilyl-6-deoxy-α-d-allopyranoside from α-d-glucose". Journal of the Serbian Chemical Society, № 00 (2024): 49. http://dx.doi.org/10.2298/jsc230831049g.

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Some of simple carbohydrates and their derivatives are used clinically for the treatment of various diseases. Epoxide derivatives, which can be obtained by the intramolecular elimination of water from two vicinal hydroxyl groups, are stable, but sufficiently reactive compounds very often used as intermediaries in various syntheses. Synthesis of epoxide derivative, methyl 3,4-anhydro-6- bromo-2-O-tert-butyldimethylsilyl-6-deoxy-?-D-allopyranoside from ?-D-glucose was achieved in high yields in the minimal number of synthetic steps. Anhydrous glucose was used as a starting material which was tra

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24

Jiang, Yin Zhi, Yong Qiang Shi, Lian Zhu Tian, and Huo Ying Xu. "Synthesis and Dye Degradation Properties of Cu²⁺ Complexes with Benzimidazole Derivatives." Advanced Materials Research 726-731 (August 2013): 2449–52. http://dx.doi.org/10.4028/www.scientific.net/amr.726-731.2449.

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Six benzimidazole derivatives were synthesized and charactrized by IR spectra, 1H-NMR spectra and MS spectra. The coordination reaction of the derivatives with CuCl2. And six novel Cu (II) complexes with the derivatives were prepared and characterized by UV spectra, IR spectra and elemental analysis. The catalytic degradation of methyl orange aqueous solution was investigated using the complexes as catalysis in presence H2O2 by HPLC method and Vis-spectrophotometry. The result of characterization showed that there are four coordination sites around Cu (II) in all complexes, which are respectiv

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25

Wojtyczka, Robert D., Andrzej Zięba, Arkadiusz Dziedzic, Małgorzata Kępa, and Danuta Idzik. "An Activity of Thioacyl Derivatives of 4-Aminoquinolinium Salts towards Biofilm Producing and Planktonic Forms of Coagulase-Negative Staphylococci." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/725939.

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Microorganisms present in different environments have developed specific mechanisms of settling on various abiotic and biotic surfaces by forming a biofilm. It seems to be well justified to search for new compounds enabling biofilm reduction, which is highly resistant to antibiotics. This study was thus an initial assessment of the antibacterial activity of two new quinoline derivatives of a structure of 3-thioacyl 1-methyl 4-arylaminoquinolinium salts against coagulase-negative staphylococci (CoNS) isolated from a hospital environment, in a form of both biofilms and in planktonic form. Thirty

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26

Patroni, JJ, RV Stick, BW Skelton та AH White. "The Selective Monobenzylidenation of Some Monosaccharides and Their Derivatives With α,α-Dimethoxytoluene". Australian Journal of Chemistry 41, № 1 (1988): 91. http://dx.doi.org/10.1071/ch9880091.

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The treatment of some monosaccharides and their derivatives with a,a-dimethoxytoluene and an acid catalyst in dimethylformamide at about 80° can lead to selective benzylidenation , e.g. methyl a-D- mannopyranoside gives mainly methyl 4,6-Obenzylidene-a-D-mannoside, together with two other minor monobenzylidene derivatives (2,3-) and two minor dibenzylidene derivatives (2,3:4,6-). The treatment of various other pyranoses and pyranosides is also described. As well, a 1H n.m.r . study of the acid transformation of some of the above α-D- mannosides is reported, together with a single-crystal X-ray

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27

Tori, Motoo, Masakazu Sono, Keiko Takikawa, et al. "Oxidation Reactions of Marchantin A Trimethyl Ether and Some Aromatic Compounds using m-Chloroperbenzoic Acid. Formation of Muconic Acid Ester and m-Chlorobenzoate." Journal of Chemical Research 23, no. 8 (1999): 470–71. http://dx.doi.org/10.1177/174751989902300808.

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On treatment with m-chloroperbenzoic acid, dihydroeugenol methyl ether and marchantin A trimethyl ether afford muconic acid ester derivatives by oxidation of the aromatic ring as well as hydroxylated derivatives; the m-chlorobenzoate of the dihydroeugenol derivative is also observed for the former.

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28

Liepa, AJ, AJ Liepa, JS Wilkie, JS Wilkie, KN Winzenberg, and KN Winzenberg. "Preparation of Some 1-Alkyl-4-[1-(ethoxyimino)butyl]-3-hydroxy-5-oxocyclohex-3-ene-1-carboxylic Acid Ester and Amide Herbicides by Reductive Alkylation of 3,5-Dimethoxybenzoic Acid." Australian Journal of Chemistry 42, no. 8 (1989): 1217. http://dx.doi.org/10.1071/ch9891217.

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Reductive alkylation of 3,5-dimethoxybenzoic acid with haloalkanes afforded the 1-alkyl- 3,5-dimethoxycyclohexa-2,5-diene-1-carboxylic acid derivatives (3a-e) which, upon esterification and hydrolysis, furnished methyl 1-alkyl-3-hydroxy-5-oxocyclohex-3-ene-l-carboxylate derivatives (4f-j). Reaction of (4f-j) with butyric anhydride gave methyl 1-alkyl-4-butyryl- 3-hydroxy-5-oxocyclohex-3-ene-1-carboxylate derivatives (6a-e) which were converted into methyl 1-alkyl-4-[1-( ethoxyimino )butyl]-3-hydroxy-5-oxocyclohex-3-ene-1-carbo xyate derivatives (2a-e). Similarly, the oxime O-ether derivative (

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29

Phutdhawong, Weerachai, Siwaporn Inpang, Thongchai Taechowisan, and Waya S. Phutdhawong. "Synthesis and Biological Activity Studies of Methyl-5-(Hydroxymethyl)-2-Furan Carboxylate and Derivatives." Oriental Journal of Chemistry 35, no. 3 (2019): 080–1085. http://dx.doi.org/10.13005/ojc/350322.

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Methyl-5-(hydroxymethyl)-2-furan carboxylate and derivatives were prepared from furfuryl alcohol and their biological activities were studied for cytotoxicity against cancer cell lines HeLa, HepG2 and Vero, and Gram (+) and Gram (-) bacteria. The amine derivative, (5-(((2-(1H-indol-3-yl)ethyl)amino)methyl) furan-2-yl)methyl acetate, was found to have the most potent biological activity with IC50 62.37 µg/mL against the HeLa cell line and MIC 250 µg/mL against the photogenic bacteria.

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30

Kazakova, Oxana B., Elena V. Tretyakova, Irina E. Smirnova, et al. "An Efficient Oxyfunctionalization of Quinopimaric Acid Derivatives with Ozone." Natural Product Communications 8, no. 3 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800304.

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An access to oxyfunctionalized quinopimaric acid derivatives is reported. The ozonolysis of methyl dihydroquinopimarate occurs through 1,2-cycloaddition of ozone to the bridging double bond followed by intermolecular rearrangements and formation of nontrivial 4β-hydroxy-4α,14α-epoxy-13(15)-ene derivative 2. The oxidation of methyl furfurilydene dihydroquinopimarate with ozone led to anhydride 5 and unexpected carboxymethyl substituted cyclopentane lactone 6. The structure of compound 6 was confirmed by X-Ray analysis of its methyl ester.

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31

Qaisi, Ali M., Mustafa M. El-Abadelah, and Wolfgang Voelter. "Direct Conversion of an ortho-Allylphenol into a Chlorosulfonyl-3-methyl-1,2-benzoxathiin 2,2-Dioxide." Zeitschrift für Naturforschung B 59, no. 9 (2004): 1059–62. http://dx.doi.org/10.1515/znb-2004-0919.

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A one-pot synthesis of methyl 6-chlorosulfonyl-3-methyl-1,2-benzoxathiin-8-carboxylate 2,2- dioxide (9), characterized as its 6-(4-methylpiperazin-1-yl)sulfonyl derivative 10, is achieved via direct reaction of methyl 3-allylsalicylate (1) with chlorosulfonic acid at −7°C. The latter reagent converts methyl 2-methyl-2,3-dihydrobenzofuran-7-carboxylate (3) into the respective 5-chlorosulfonyl derivative 7 (identified as its 5-(4-methylpiperazin-1-yl)sulfonyl derivative 8), while contrary to literature reports, the aromatic δ -sultones 9, 10 (anticipated to be produced from 3) were not detected.

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32

Bădiceanu, Carmellina Daniela, Catalina Mares, Diana Camelia Nuță, et al. "N-Substituted (Hexahydro)-1H-isoindole-1,3(2H)-dione Derivatives: New Insights into Synthesis and Characterization." Processes 11, no. 6 (2023): 1616. http://dx.doi.org/10.3390/pr11061616.

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Novel phthalimide derivatives, namely N-(1,3-dioxoisoindolin-2-yl)-2-(2-methyl-4-oxoquinazolin-3(4H)-yl)acetamide (1a) and N-(1,3-dioxoisoindolin-2-yl)thiophene-2-carboxamide (1b), and hexahydrophthalimide derivative N-(1,3-dioxohexahydro-1H-isoindol-2(3H)-yl)-2-(2-methyl-4-oxoquinazolin-3(4H)-yl)acetamide (2), have been synthesized. The phthalimide derivatives were synthesized from phthalic anhydride and 2-(2-methyl-4-oxoquinazolin-3(4H)-yl)acetohydrazide or thiophene-2-carbohydrazide, and the hexahydrophthalimide derivative has been synthesized from hexahydrophthalic anhydride and 2-(2-methy

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33

Kmínek, Ivan, Stanislav Nešpůrek, Eduard Brynda, Jiří Pfleger, Věra Cimrová, and Wolfram Schnabel. "Poly(methyl-phenylsilylene) Derivatives as Photoconductors." Collection of Czechoslovak Chemical Communications 58, no. 10 (1993): 2337–48. http://dx.doi.org/10.1135/cccc19932337.

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The attachment of long wavelength absorbing π-conjugated chromophores to poly(methyl-phenylsilylene) (PMPSi) via reactions of its formylated derivative is described. Some of the obtained polymers exhibit improved photostability in comparison with the parent polymer. Their spectral properties and photoconductivity are discussed. Ultrathin layers and multilayers were prepared from polar derivatives of PMPSi by the Langmuir-Blodgett technique and their photoconductive behaviour was studied.

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34

Khalifa, Nagy M., Ahmed M. Naglah, Mohamed A. Al-Omar, Mohamed H. Abo-Ghalia, and Abd El-Galil E. Amr. "Synthesis and Reactions of New Chiral Linear Carboxamides with an Incorporated Peptide Linkage Using Nalidixic Acid and Amino Acids as Starting Materials." Zeitschrift für Naturforschung B 69, no. 3 (2014): 351–61. http://dx.doi.org/10.5560/znb.2014-3282.

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4bA series of chiral linear carboxamide derivatives (2- 15) with an incorporated peptide linkage have been prepared via the coupling of 1-ethyl-1,4-dihydro-7-methyl-4-oxo-quinoline-3-carboxylic acid (nalidixic acid, 1) with appropriate amino acid methyl esters. Coupling of 1 with amino acid methyl esters gave the corresponding peptide methyl esters 2, which were hydrolyzed with methanolic sodium hydroxide to the corresponding acids 3. Hydrazinolysis of esters 2with hydrazine hydrate afforded the corresponding acid hydrazide derivatives 4. The latter compounds were coupled with appropriate alde

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35

Purwono, Bambang, Chairil Anwar, and Ahmad Hanapi. "Syntheses of Azo-Imine Derivatives from Vanillin as an Acid Base Indicator." Indonesian Journal of Chemistry 13, no. 1 (2013): 1–6. http://dx.doi.org/10.22146/ijc.21318.

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Preparations of azo, imine and azo-imine derivatives from vanillin as an indicator of acid-base titration have been carried out. The azo derivative of 4-hydroxy-3-methoxy-5-(phenylazo)benzaldehyde 2 was produced by diazotitation reaction of vanillin in 37.04% yield. The azo product was then refluxed with aniline in ethanol to yield azo-imine derivatives, 2-methoxy-6-(phenylazo)-4-((phenylimino)methyl)phenol 1 in 82.21% yield. The imine derivative, 2-methoxy-4-((phenylimino)methyl)-phenol 3 was obtained by refluxing of vanillin and aniline mixture in ethanol solvent and produced 82.17% yield. T

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36

Dhaef, Hawraa Kareem, Rafid Humaidan Al-Asadi, Ashwaq Abood Shenta, and Mohammed Khalaf Mohammed. "Novel Bis Maleimide Derivatives Containing Azo Group: Synthesis, Corrosion Inhibition, and Theoretical Study." Indonesian Journal of Chemistry 21, no. 5 (2021): 1212. http://dx.doi.org/10.22146/ijc.64614.

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Novel derivatives of heterocyclic azo compounds have been synthesized through a free catalyst reaction. The structures of the synthesized compounds were confirmed by using different techniques such as 1H-NMR, 13C-NMR, and mass spectroscopy. The prepared derivatives were evaluated as corrosion inhibitors for mild steel after the inhibitory performance toward mild steel in 0.1 M HCl solution. The prepared derivatives, i.e. (1,1'-(((1E,1'E)-1,4-Phenylenebis(diazene-2,1-diyl))bis(4-methyl-3,1-phenylene))bis(1H-pyrrole-2, 5-dione)) 1 and (1,1'-(((1Z,1'Z)-(Oxybis(4,1-phenylene))bis(diazene-2,1-diyl)

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37

Collins, David J., Timothy C. Hughes, and Wynona M. Johnson. "Dihydro-1,2,4-triazin-6(1H)-ones. III. Oxidation Products of 1-Methyl-3-phenyl- 4,5-dihydro-1,2,4-triazin-6(1H)-one." Australian Journal of Chemistry 52, no. 10 (1999): 971. http://dx.doi.org/10.1071/ch99047.

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1-Methyl-3-phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one (1) undergoes aerial oxidation to give a mixture of 1- methyl-3-phenyl-1,2,4-triazin-6(1H)-one (2) and 1-methyl-3-phenyl-1,4-dihydro-1,2,4-triazine-5,6-dione (3). The dehydro derivative (2) was cleanly prepared by the oxidation of (1) with 2,3-dichloro-5,6-dicyano-1,4- benzoquinone (ddq). The dehydro derivative (2) underwent a surprising rearrangement to the triazole (12) upon oxidation with OxoneR. Several attempts at unambiguous synthesis of the α-dicarbonyl derivative (3) were unsuccessful; it was obtained, together with the 1,4-dimethyl

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38

Mardjan, Muhammad Idham Darussalam, Retno Ambarwati, Sabirin Matsjeh, Tutik Dwi Wahyuningsih, and Winarto Haryadi. "SYNTHESIS OF FLAVANONE-6-CARBOXYLIC ACID DERIVATIVES FROM SALICYLIC ACID DERIVATIVE." Indonesian Journal of Chemistry 12, no. 1 (2012): 70–76. http://dx.doi.org/10.22146/ijc.21374.

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Synthesis of flavanone-6-carboxylic acid derivatives had been conducted via the route of chalcone. The synthesis was carried out from salicylic acid derivative, i.e. 4-hydroxybenzoic acid, via esterification, Fries rearrangement, Claisen-Schmidt condensation and 1,4-nucleophilic addition reactions. Structure elucidation of products was performed using FT-IR, 1H-NMR, GC-MS and UV-Vis spectrometers. Reaction of 4-hydroxybenzoic acid with methanol catalyzed with sulfuric acid produced methyl 4-hydroxybenzoate in 87% yield. The acid-catalyzed-acetylation of the product using acetic anhydride gave

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39

Elkin, Igor, Thierry Maris, and Patrice Hildgen. "Synthesis and characterization of 3-methyl-6-[(propynyloxy)methyl]-1,4-dioxane-2,5-dione." Acta Crystallographica Section E Crystallographic Communications 73, no. 7 (2017): 1044–47. http://dx.doi.org/10.1107/s2056989017008581.

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The number of known asymmetrically substituted hemilactides, important precursors for obtaining regular derivatives of polylactide polymers, is still limited and structural characterization of most of them is incomplete. In the title racemic 1,4-dioxane-2,5-dione derivative, C9H10O5, the hemilactide heterocycle exhibits a twist-boat conformation. The bulkier propynyloxymethyl group is in an axial position with agaucheconformation for the CH2–O–CH2–C segment. In the crystal, molecules are linked by pairs of C—H...O hydrogen bonds, forming inversion dimers. The dimers are linked by further C—H..

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40

Schaefer, Ted, Rudy Sebastian, Glenn H. Penner, and S. R. Salman. "The proximate spin–spin coupling, 5J(F,CH3), as a quantitative conformational indicator in alkylfluorobenzenes and related compounds." Canadian Journal of Chemistry 64, no. 8 (1986): 1602–6. http://dx.doi.org/10.1139/v86-266.

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The through-space or proximate nuclear spin–spin coupling constant, 5J(F,CH3) = 5J, between methyl protons and ring fluorine nuclei in alkylfluorobenzenes is postulated as [Formula: see text] θ being the torsional angle for the [Formula: see text] bond. A and B are obtained from the known internal rotational behaviour in 2,6-difluoroethylbenzene and the corresponding cumene derivative. The parameterization is tested on the observed 5J in derivatives of 2,4,6-tri-tert-butyl- and 2,4,6-tri-isopropyl-fluorobenzene, in 2-chloro-6-fluoroisopropylbenzene, 2,6-difluoro-α-methylstyrene, and N-methyl-8

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41

Havelková, Martina, Martin Studenovský, and Dalimil Dvořák. "N1-Substituted Hypoxanthine Derivatives from the Reaction of 6-Halopurines with Michael Acceptors Under the Conditions of Heck Reaction." Collection of Czechoslovak Chemical Communications 65, no. 5 (2000): 797–804. http://dx.doi.org/10.1135/cccc20000797.

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The reaction of 6-iodo-, 9-benzyl-6-chloropurine and 7-benzyl-6-chloropurine with butyl acrylate, acrylonitrile, methyl vinyl ketone or methyl methacrylate under conditions of the Heck reaction in the presence of TlOAc or AgOAc afforded N1-alkylhypoxanthine derivatives. Formation of these unexpected products can be rationalised as a Tl+- or Ag+-assisted substitution of halogen with acetate anion. The 6-acetoxypurine derivative thus formed then eliminates ketene and gives 7-benzyl- or 9-benzylhypoxanthine. Conjugate addition of these compounds onto Michael acceptors furnishes the N1-substituted

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42

Neamah, Rawaa, та Shaimaa Adnan. "Study the Biological Activity for Shiff Base and Β – Lactam Compounds that Synthesis and Identification from Pyrimidine Derivatives". International Journal of Pharmaceutical Quality Assurance 11, № 01 (2013): 37–39. http://dx.doi.org/10.25258/ijpqa.11.1.12.

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In This study We are synthesis and characterization of some Schiff base and β- lactam derivatives) by three steps. The First react 2-amino-4-Chloro-6-methyl pyrimidine with 4-amino acetophenone in an acid medium to get shiff base derivative(E)-4-(1-((4-Chloro-6-methyl pyridine-2-yl)imino)ethyl)aniline (1), the second step (1) react with (3,4- dimethoxybenzal dehyde,4-methyl benzaldehyde,4-dimethylamino benzaldehyde,4-bromo benzaldehyde,4–hydroxy benzaldehyde, 4-Nitro benzaldehyde) to get Schiff base derivatives (2-7), the last step (2-7) derivatives react with Chloro acetyl chloride to get –β-

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43

Janeba, Zlatko, Antonín Holý, and Milena Masojídková. "Transformation of 8-[(2-Hydroxyalkyl)sulfanyl]adenines to 6-Amino-7H-purin-8(9H)-one Derivatives." Collection of Czechoslovak Chemical Communications 66, no. 9 (2001): 1393–406. http://dx.doi.org/10.1135/cccc20011393.

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Alkylation of 6-amino-7H-purin-8(9H)-thione (8-sulfanyladenine, 1) with one equivalent of (R)-[(trityloxy)methyl]oxirane gave its S-alkyl derivative 2, which was converted to the 6-amino-7H-purin-8(9H)-one (3), while alkylation of 1 with two equivalents of (S)-[(trityloxy)methyl]oxirane afforded a mixture of N3,S-dialkylated product 4a, N9-monoalkyl and N7,N9-dialkyl derivatives of 6-amino-7H-purin-8(9H)-one, 5a and 6a, respectively. This approach can be used for rapid and easy transformation of 8-[(2-hydroxyalkyl)sulfanyl]adenines to the derivatives of 6-amino-7H-purin-8(9H)-one (8-hydroxyade

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44

Collins, DJ, TC Hughes, and WM Johnson. "Regiospecific Syntheses of the Monomethylated 3-Phenyldihydro-1,2,4-triazin-6(1H)-ones." Australian Journal of Chemistry 49, no. 4 (1996): 463. http://dx.doi.org/10.1071/ch9960463.

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Unambiguous syntheses of four unreported monomethylated derivatives of 3-phenyldihydro-1,2,4-triazin-6(1H)-ones, namely, the 1-methyl (2), 2-methyl (3), 4-methyl (4) and the imidic O-methyl derivative (5), are described. Regioselectivity was achieved for the synthesis of (2) by addition of ethyl glycinate to the 1,3-dipolar nitrile imine derived from N- methylbenzohydrazonoyl bromide hydrobromide (8). The key step for the synthesis of (3) was addition of benzyl 3-methylcarbazate (14) to ethyl N-[ chloro (phenyl) methylene ] glycinate (15b). The 4-methyl compound (4) was prepared by cycloadditi

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45

Grote, Michaela, Steffi Noll, Bernhard Noll, Bernd Johannsen, and Werner Kraus. "Syntheses of novel modified acyclic purine and pyrimidine nucleosides as potential substrates of herpes simplex virus type-1 thymidine kinase for monitoring gene expression." Canadian Journal of Chemistry 82, no. 4 (2004): 513–23. http://dx.doi.org/10.1139/v04-005.

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Suicide gene therapy with the herpes simplex virus type-1 thymidine kinase gene (HSV-1 tk) is considered to be a promising approach to the treatment of cancer. Making use of the lower specificity of the viral enzyme compared to human thymidine kinase, the therapy involves the administration of antiviral agents (e.g., ganciclovir) as prodrugs to induce enzymatic cell death in those cells that express the transferred gene. 18F-labelled derivatives have been described for monitoring location, duration, and magnitude of the viral kinase enzyme activity by positron emission tomography (PET). Since

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46

Kawsar, Sarkar M. A., Samia S. B. S. Nishat, Mohammad A. Manchur та Yasuhiro Ozeki. "Benzenesulfonylation of Methyl α-D-Glucopyranoside: Synthesis, Characterization and Antibacterial Screening". International Letters of Chemistry, Physics and Astronomy 64 (лютий 2016): 95–105. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.64.95.

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A novel series of benzenesulfonyl derivatives of methyl α-D-glucopyranoside (1) were synthesized by reacting benzenesulfonyl chloride in pyridine followed by direct acylation method to yield 6-O-benzenesulfonyl derivative (2). In order to obtain newer products for antibacterial evaluation studies, the 6-O-benzenesulfonyl derivative was further transformed to a series of 2,3,4-tri-O-acyl derivatives (3-11) containing a wide variety of functionalities in a single molecular framework. All the synthesized compounds have been confirmed by IR,1H NMR and elemental analysis. These newly synthesized co

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47

Kawsar, Sarkar M. A., Samia S. B. S. Nishat, Mohammad A. Manchur та Yasuhiro Ozeki. "Benzenesulfonylation of Methyl α-D-Glucopyranoside: Synthesis, Characterization and Antibacterial Screening". International Letters of Chemistry, Physics and Astronomy 64 (15 лютого 2016): 95–105. http://dx.doi.org/10.56431/p-637009.

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A novel series of benzenesulfonyl derivatives of methyl α-D-glucopyranoside (1) were synthesized by reacting benzenesulfonyl chloride in pyridine followed by direct acylation method to yield 6-O-benzenesulfonyl derivative (2). In order to obtain newer products for antibacterial evaluation studies, the 6-O-benzenesulfonyl derivative was further transformed to a series of 2,3,4-tri-O-acyl derivatives (3-11) containing a wide variety of functionalities in a single molecular framework. All the synthesized compounds have been confirmed by IR, 1H NMR and elemental analysis. These newly synthesized c

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48

Harnden, MR, and DT Hurst. "The Chemistry of Pyrimidinethiols. III. The Synthesis of Some Substituted Pyrimidinthiols and Some Thiazolo[5,4-D]pyrimidines." Australian Journal of Chemistry 43, no. 1 (1990): 55. http://dx.doi.org/10.1071/ch9900055.

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The preparation of a number of pyrimidinethiols and (substituted) thiopyrimidines has been carried out. The reaction of 5-acetylamino-2-aminopyrimidine-4,6-diol with phosphorus penta -sulfide in pyridine gave 5-amino-2-methylthiazolo[5,4-d]pyrimidine-7-thiol which was used to prepare several additional novel pyrimidine derivatives. Hydrolysis of the 4-carboxymethylthio derivative by using 5M hydrochloric acid gave 2,5-diamino-6-mercaptopyrimidin-4-ol hy -drochloride whilst hydrolysis of 2-methyl-7-methylthiothiazolo[5,4-d]pyrimidin-5-amine gave the corresponding 4-hydroxy derivative. Several 4

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49

Napiórkowska, Mariola, Emilia Grosicka-Maciąg, Piotr Podsadni, and Dagmara Otto-Ślusarczyk. "Anticancer Potential of Halogen Derivatives of Methyl 6-Acetyl-5-Hydroxy-2-Methyl-1-Benzofuran-3-Carboxylate." International Journal of Molecular Sciences 26, no. 12 (2025): 5493. https://doi.org/10.3390/ijms26125493.

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The presented results are a continuation of our research on the synthesis and biological properties of halogen benzofuran derivatives, particularly their anticancer potential. We examined the cytotoxicity of two derivatives, methyl 4-chloro-6-(dichloroacetyl)-5-hydroxy-2-methyl-1-benzofuran-3-carboxylate (7) and methyl 6-(dibromoacetyl)-5-methoxy-2-methyl-1-benzofuran-3-carboxylate (8), in the following human cancer cell lines: SW480, SW620, HCT116, HepG2, PC3, A549, and MDA. The MTT assay results showed that compound 7 exhibited the most promising activity against A549 cells, while compound 8

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50

Vadla, Balakishan, Naveen Puram, and Sailu Betala. "Novel trifluoromethyl-thieno[2,3-b]pyridine-2-carboxamide and Schiff’s base derivatives and their anticancer activity." Research Journal of Chemistry and Environment 27`, no. 9 (2023): 69–74. http://dx.doi.org/10.25303/2709rjce069074.

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A series of novel trifluoromethyl-thieno[2,3-b] pyridine-2-carboxamide 3a-h and Schiff’s base derivatives 5a-g was prepared starting from 6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carb onitrile 1. Compound 1 on reaction with bromoethyl acetate produced ester derivative 2 on reaction with different amines produced amide derivatives 3. Ester derivative 2 which on reaction with hydrazine hydrate gave hydrazide 4 derivative. Further this compound on reaction with different substituted aromatic aldehydes formed Schiff’s base derivatives 5. All the products 3a-h and 5a-f were screened

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