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Journal articles on the topic 'Methylisoxazole'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

J., VIROOPAKSHAPPA, and VITHAL RAO D. "Synthesis and Characterisation of Cobalt(II), Nickel(II) and Copper(II) Chelates of 3-(2-Hydroxy-5-chlorobenzylideneamino)-5-methylisoxazole and 3-(2-Hydroxy- 5-bromobenzylideneamino)-5-methylisoxazole." Journal of Indian Chemical Society Vol. 73, Oct 1996 (1996): 531–32. https://doi.org/10.5281/zenodo.5910404.

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Department of Chemistry, Kakatiya University, Warangal-506 009 <em>Manuscript received  28 December 1993, revised  25 January 1995, accepted 16 February 1995</em> Synthesis and Characterisation of Cobalt(II), Nickel(II) and Copper(II) Chelates of 3-(2-Hydroxy-5-chlorobenzylideneamino)-5-methylisoxazole and 3-(2-Hydroxy- 5-bromobenzylideneamino)-5-methylisoxazole.

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2

Pelit, Emel. "Synthesis of Isoxazolopyridines and Spirooxindoles under Ultrasonic Irradiation and Evaluation of Their Antioxidant Activity." Journal of Chemistry 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/9161505.

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New polycyclic-fused isoxazolo[4,5-e]pyridines and spirooxindoles were obtained via multicomponent reaction of 5-amino-3-methylisoxazole, indan-1,3-dione, and aromatic aldehydes and reaction of 5-amino-3-methylisoxazole, isatin, and β-diketones in the presence of (±)-camphor-10-sulfonic acid as an effective and nontoxic organocatalyst under ultrasound-promoted conditions. The antioxidant activity of the novel synthesized compounds was studied.

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3

Martins, Marcos, Marcelo Neto, Adilson Sinhorin, et al. "SYNTHESIS OF 3-METHYLISOXAZOLE- 5-CARBOXAMIDES AND 5-[(1H-PYRAZOL-1-YL)CARBONYL]- 3-METHYLISOXAZOLES." Synthetic Communications 32, no. 3 (2002): 425–33. http://dx.doi.org/10.1081/scc-120002127.

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4

Wang, De-Cai, Wei Xu, and Wen-Yuan Wu. "5-Methylisoxazole-4-carboxylic acid." Acta Crystallographica Section E Structure Reports Online 65, no. 12 (2009): o3140. http://dx.doi.org/10.1107/s1600536809048636.

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5

Song, Yaoming, Yiguan Zhang, An-Rong Lee, et al. "Comparison of Two Molecular Scaffolds, 5-Methylisoxazole-3-Carboxamide and 5-Methylisoxazole-4-Carboxamide." Current Pharmaceutical Design 20, no. 1 (2014): 146–52. http://dx.doi.org/10.2174/13816128113199990584.

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6

Bedoukian, Matthew A., Jennifer D. Whitesell, Erik J. Peterson, Colin M. Clay, and Kathryn M. Partin. "The Stargazin C Terminus Encodes an Intrinsic and Transferable Membrane Sorting Signal." Journal of Biological Chemistry 283, no. 3 (2007): 1597–600. http://dx.doi.org/10.1074/jbc.m708141200.

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Activity-dependent plasticity of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors is regulated by their auxiliary subunit, stargazin. Association with stargazin enhances α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor surface expression and modifies the receptor's biophysical properties. Fusing the cytoplasmic C terminus of stargazin to the C-terminal domains of either GluR1 or the gonadotropin-releasing hormone receptor permits efficient trafficking from the endoplasmic reticulum and sorting to the basolateral membrane without altering other properties of either re

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7

Liu, Kang, Yong Xiong, Zuo-Fei Wang, Hai-Yan Tao, and Chun-Jiang Wang. "Ligand-controlled stereodivergent 1,3-dipolar cycloaddition of azomethine ylides with 3-methyl-4-nitro-5-styrylisoxazoles." Chemical Communications 52, no. 60 (2016): 9458–61. http://dx.doi.org/10.1039/c6cc03169b.

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An unprecedented Ag(i)-catalyzed ligand-controlled stereodivergent 1,3-dipolar cycloaddition of azomethine ylides with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford heterocycles bearing both methylisoxazole and pyrrolidine moieties.

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8

Jin, Yan-Xian, Wen-Ping Jia, Jun-Yong Wu, and Hua Yan. "(E)-N′-Benzylidene-5-methylisoxazole-4-carbohydrazide." Acta Crystallographica Section E Structure Reports Online 66, no. 1 (2009): o123. http://dx.doi.org/10.1107/s1600536809052969.

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9

Chang, Xin-Hong. "3-(2-Chlorophenyl)-N-methylisoxazole-5-carboxamide." Acta Crystallographica Section E Structure Reports Online 63, no. 7 (2007): o3074. http://dx.doi.org/10.1107/s1600536807025895.

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10

Sony, S. M. Malathy, P. Charles, M. N. Ponnuswamy, H. S. Yathirajan, and M. Nethaji. "Ethyl 5-amino-3-methylisoxazole-4-carboxylate." Acta Crystallographica Section E Structure Reports Online 61, no. 1 (2004): o198—o200. http://dx.doi.org/10.1107/s1600536804033720.

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11

Abel, M. D., A. D. Cameron, C. M. Ha, et al. "Novel Azolylalkyloxy Compounds with Antipicornaviral Activity." Antiviral Chemistry and Chemotherapy 6, no. 4 (1995): 245–54. http://dx.doi.org/10.1177/095632029500600407.

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A novel series of azolylalkyloxy compounds was designed, synthesized and evaluated for antipicornaviral activity. Several of the compounds exhibited in vitro activity comparable to that of Disoxarll. An investigation of qualitative structure-activity relationships indicated that the optimal length of the alkyI chain is six or seven carbon atoms, with seven being marginally superior. The effect of different azole moieties on activity was relatively small, with 3-methylisoxazole and 4-methylthiazole being most effective. The nature of the oxy substituent was found to be extremely important for a

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12

Martins, Marcos A. P., Marcelo Neto, Adilson P. Sinhorin, et al. "ChemInform Abstract: ChemInform Abstract: Synthesis of 3-Methylisoxazole-5-carboxamides and 5-[(1H-Pyrazol-1-yl)carbonyl]-3-methylisoxazoles." ChemInform 33, no. 26 (2002): no. http://dx.doi.org/10.1002/chin.200226135.

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13

Vovk, M. V., A. V. Bolbut, and V. I. Dorokhov. "Cyclizations of N-(1-Chloro-2,2,2-trihaloethylidene)-O-methylurethanes with 5-Amino-3-methylisoxazole and 3-Amino-5-methylisoxazole." Chemistry of Heterocyclic Compounds 40, no. 4 (2004): 496–99. http://dx.doi.org/10.1023/b:cohc.0000033544.82905.6b.

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14

Sakamoto, Takao, Daishi Uchiyama, Makoto Yabe, Hiroshi Kameyama, Yoshinori Kondo, and Hiroshi Yamanaka. "Synthesis and Reactions of 4-Tributylstannyl-3-methylisoxazole." HETEROCYCLES 43, no. 6 (1996): 1301. http://dx.doi.org/10.3987/com-96-7489.

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15

Shen, Liang, Mei Chao Li, Zhi Min Jin, Mao Lin Hu та Ri Cheng Xuan. "Bis(3-amino-5-methylisoxazole-κN)dichlorozinc(II)". Acta Crystallographica Section E Structure Reports Online 60, № 3 (2004): m330—m331. http://dx.doi.org/10.1107/s1600536804003939.

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16

Chandra, K. Raghu, N. Srikantamurthy, K. B. Umesha, K. Palani, and M. Mahendra. "3-(4-Methoxyphenyl)-5-methylisoxazole-4-carboxylic acid." Acta Crystallographica Section E Structure Reports Online 69, no. 3 (2013): o388. http://dx.doi.org/10.1107/s1600536813004029.

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17

Sauers, Ronald R., and Susan D. Van Arnum. "A convenient preparation of 3-acetyl-5-methylisoxazole." Journal of Heterocyclic Chemistry 40, no. 4 (2003): 655–58. http://dx.doi.org/10.1002/jhet.5570400415.

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18

Batchelor, Kevin J., W. Russell Bowman, Roy V. Davies, Michael H. Hockley, and David J. Wilkins. "Regioselective Addition of Grignard Reagents to Isoxazole-4,5-dicarboxylate Esters." Journal of Chemical Research 23, no. 7 (1999): 428–29. http://dx.doi.org/10.1177/174751989902300712.

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Regioselective mono-addition of a range of Grignard reagents with the 5-esters of 3-methylisoxazole-4,5-diesters affords 5-keto derivatives instead of tertiary alcohols which is explained by the complexing ability of the isoxazole oxygen atom and by the electron withdrawing effect of the isoxazole ring.

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19

Chao, Shujun, and Yingling Wang. "Synthesis of Novel S-Glucosides Containing 5-Methylisoxazole Substituted 1,2,4-Triazole." Journal of Chemistry 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/568907.

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Nine new S-β-D-glucosides containing 4-aryl-5-(5-methylisoxazol-3-yl)-1,2,4-triazol-3-thiols have been synthesized by the direct glycosylation of 4-aryl-5-(5-methylisoxazol-3-yl)-1,2,4-triazol-3-thiols with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide in ethanol in the presence of potassium hydroxide followed by deacetylation using dry ammonia in dry methanol. All the compounds synthesized have been characterized by their elemental analyses and spectral data.

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20

Zhong, Bin, Xiao-Li Mu, Zheng-Ming Li, and Hai-Bin Song. "N-(1-Cyano-1,2-dimethylpropyl)-5-methylisoxazole-4-carboxamide." Acta Crystallographica Section E Structure Reports Online 60, no. 10 (2004): o1797—o1799. http://dx.doi.org/10.1107/s1600536804022743.

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21

Jin, Yan-Xian, Zhen-Zhong Yan, Jian-Guo Yang, Ai-Guo Zhong, and Fu-You Pan. "N′-[(E)-2-Hydroxybenzylidene]-5-methylisoxazole-4-carbohydrazide monohydrate." Acta Crystallographica Section E Structure Reports Online 65, no. 12 (2009): o3113. http://dx.doi.org/10.1107/s1600536809048028.

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22

Ortyl, Ewelina, Jolanta Jaworowska, Payman Tajalli Seifi, Regis Barille, and Stanisław Kucharski. "Photochromic Polymer and Hybrid Materials Containing Azo Methylisoxazole Dye." Soft Materials 9, no. 4 (2011): 335–46. http://dx.doi.org/10.1080/1539445x.2010.525434.

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23

Wang, De-Cai, Liang-Cheng Huang, Zhu-Yun Liu, Ping Wei, and Ping-Kai Ou-yang. "N-(4-Chloro-2-nitrophenyl)-5-methylisoxazole-4-carboxamide." Acta Crystallographica Section E Structure Reports Online 67, no. 12 (2011): o3332. http://dx.doi.org/10.1107/s1600536811047994.

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24

Lifshitz, Assa, and Dror Wohlfeiler. "Thermal decomposition of 5-methylisoxazole. Experimental and modeling study." Journal of Physical Chemistry 96, no. 18 (1992): 7367–75. http://dx.doi.org/10.1021/j100197a043.

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25

Wu, Michael, Stefan M. Brudzynski, and Gordon J. Mogenson. "Functional interaction of dopamine and glutamate in the nucleus accumbens in the regulation of locomotion." Canadian Journal of Physiology and Pharmacology 71, no. 5-6 (1993): 407–13. http://dx.doi.org/10.1139/y93-061.

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The interaction of dopamine and glutamate in the nucleus accumbens in the regulation of locomotion was investigated. Microinjection of N-methyl-D-aspartic acid (NMDA, a glutamatergic NMDA receptor agonist) or α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA, a quisqualic receptor agonist which is a glutamatergic non-NMDA receptor agonist) into the nucleus accumbens caused a substantial increase in locomotor activity. This increase in locomotor activity was significantly reduced by prior administration of the dopamine D2 agonist quinpirole, but not the D1 agonist, SKF 38393, into the same

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26

Marciocha, D., J. Kalka, J. Turek-Szytow, J. Wiszniowski, and J. Surmacz-Górska. "Oxidation of sulfamethoxazole by UVA radiation and modified Fenton reagent: toxicity and biodegradability of by-products." Water Science and Technology 60, no. 10 (2009): 2555–62. http://dx.doi.org/10.2166/wst.2009.651.

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Improvement of sulfamethoxazole (4-amino-N-(5-methylisoxazol-3-yl)-benzenesulfonamide—SMX) biodegradability using a modified Fenton's reaction has been studied. The modification consists of replacing hydrogen peroxide with atmospheric air and adding copper sulphate as a reaction promoter. Two series of experiments were carried out. The first (Series 1) was conducted using only the catalysts with aeration. In the second series (Series 2), cycles of UVA radiation and aeration were used. During UVA radiation, the removal of sulfamethoxazole proceeds less rapidly than in only aerated solution. Aft

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27

Liu, Jinyu, Zuwen Zhou, Jian Liu, et al. "Synthesis and Investigation on the Antidiabetic Effect of 3-aryl-1-(5-methylisoxazol-3-ylamino)-1-(4-nitrophenyl) Propan-1-one." Letters in Drug Design & Discovery 16, no. 8 (2019): 835–45. http://dx.doi.org/10.2174/1570180815666180608101529.

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Background: Diabetes mellitus is the third-largest non-communicable chronic disease worldwide. There are many effective drugs, but the long-term use of these clinical drugs may cause various side effects. Therefore, it is urgent to develop new antidiabetic molecules with higher efficacy and lower toxicity. Methods: Fifteen new 3-aryl-1-(5-methylisoxazol-3-ylamino)-1-(4-nitrophenyl)propan-1-one were synthesized directly through the Mannich reaction of 4-nitroacetophenone, 3-amino-5- methylisoxazole and aromatic aldehydes catalyzed by concentrated hydrochloric acid. The molecular structures of t

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28

Lee, Shi Yong. "Preparation, Alkylation, and Olefination Reaction of 5-Phosphonomethyl-3-methylisoxazole." Synthesis 1999, no. 12 (1999): 2027–29. http://dx.doi.org/10.1055/s-1999-3625.

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29

UCHIYAMA, D., M. YABE, H. KAMEYAMA, T. SAKAMOTO, Y. KONDO, and H. YAMANAKA. "ChemInform Abstract: Synthesis and Reactions of 4-Tributylstannyl-3-methylisoxazole." ChemInform 27, no. 43 (2010): no. http://dx.doi.org/10.1002/chin.199643098.

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30

Filimonov, Sergey I., Mikhail K. Korsakov, Mikhail V. Dorogov, Dmitry V. Kravchenko, Sergey E. Tkachenko, and Alexandre V. Ivachtchenko. "Convenient synthesis of novel 5-substituted 3-methylisoxazole-4-sulfonamides." Journal of Heterocyclic Chemistry 43, no. 3 (2006): 663–71. http://dx.doi.org/10.1002/jhet.5570430320.

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31

Jäger, W., H. Dreizler, H. Mäder, J. Sheridan, and C. T. Walls. "The Microwave Spectrum of 4-Methylisoxazole: 14N Nuclear Quadrupole Coupling, Methyl Internal Rotation and Electric Dipole Moment." Zeitschrift für Naturforschung A 42, no. 5 (1987): 501–6. http://dx.doi.org/10.1515/zna-1987-0513.

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The microwave spectrum of 4-methylisoxazole has been investigated in the frequency range from 8 to 40 GHz, employing both Stark and Fourier transform spectroscopy. We present the results from a 14N quadrupole hyperfine structure, a fourth-order centrifugal distortion and an IAM methyl internal rotation analysis. The components of the electric dipole moment with respect to the principal axes of inertia have been obtained from the Stark splittings of some rotational lines.

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32

Tkachenko, Volodymyr V., Elena A. Muravyova, Sergey M. Desenko, et al. "The unexpected influence of aryl substituents in N-aryl-3-oxobutanamides on the behavior of their multicomponent reactions with 5-amino-3-methylisoxazole and salicylaldehyde." Beilstein Journal of Organic Chemistry 10 (December 17, 2014): 3019–30. http://dx.doi.org/10.3762/bjoc.10.320.

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The switchable three-component reactions of 5-amino-3-methylisoxazole, salicylaldehyde and N-aryl-3-oxobutanamides under different conditions were studied and discussed. The unexpected influence of the aryl substituent in N-aryl-3-oxobutanamides on the behavior of the reaction was discovered. The key influence of ultrasonication and Lewis acid catalysts led to an established protocol to selectively obtain two or three types of heterocyclic scaffolds depending on the substituent in the N-aryl moiety.

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33

Montjoie, A. S., W. Müller-Warmuth, Hildegard Stiller, and J. Stanislawski. "Methyl Group Rotation and Tunnellingin Crystals of 5-Membered Ring Molecules." Zeitschrift für Naturforschung A 43, no. 1 (1988): 35–42. http://dx.doi.org/10.1515/zna-1988-0105.

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Abstract1H NMR spin-lattice relaxation times T1 and -if accessible -level-crossing peaks and inelastic neutron scattering spectra have been measured for solid 2-and 3-methylfuran, 2-and 3-methylthiophene, 3-and 4-methylpyrazole, 1-methylimidazole, and 5-methylisoxazole. From the tunnel splittings, the torsional excitations and the NMR relaxation rates, the molecular dynamics of the methyl rotators has been evaluated between the limits of quantum tunnelling at low temperatures and thermally activated random reorientation at elevated temperatures.

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34

Hanley, J. G. "Molecular mechanisms for regulation of AMPAR trafficking by PICK1." Biochemical Society Transactions 34, no. 5 (2006): 931–35. http://dx.doi.org/10.1042/bst0340931.

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AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor trafficking is a fundamental mechanism for regulating synaptic strength, and hence may underlie cellular processes involved in learning and memory. PICK1 (protein that interacts with protein C-kinase) has recently emerged as a key regulator of AMPAR (AMPA receptor) traffic, and the precise molecular mechanisms of PICK1's action are just beginning to be unravelled. In this review, I summarize recent findings that describe some important molecular characteristics of PICK1 with respect to AMPAR cell biology.

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35

Fliege, E., H. Dreizler, J. Sheridan, and C. T. Walls. "Internal rotation and 14N quadrupole coupling of 3- and 5-methylisoxazole." Journal of Molecular Spectroscopy 113, no. 2 (1985): 362–72. http://dx.doi.org/10.1016/0022-2852(85)90275-9.

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36

Zhong, Ai-Guo, and et al. "Crystal structure of 2-hydroxybenzylidene-5-methylisoxazole-4- carbohydrazide monohydrate, C12H13N3O4." Zeitschrift für Kristallographie - New Crystal Structures 227, no. 4 (2012): 495–96. http://dx.doi.org/10.1524/ncrs.2012.0196.

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37

Morozova, Alisa D., Elena A. Muravyova, Svitlana V. Shishkina, et al. "Features of 3-amino-5-methylisoxazole in heterocyclizations involving pyruvic acids." Chemistry of Heterocyclic Compounds 55, no. 1 (2019): 78–89. http://dx.doi.org/10.1007/s10593-019-02422-8.

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38

Davico, Gustavo E. "Theoretical study of the thermal isomerization of isoxazole and 5-methylisoxazole." Journal of Physical Organic Chemistry 18, no. 5 (2005): 434–40. http://dx.doi.org/10.1002/poc.879.

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39

Sun, De-Guang, Xin-Ping Hui, Peng-Fei Xu, Zi-Yi Zhang, and Zuo-Wu Guan. "Synthesis of Novel Biphenyltetrazole Derivatives Containing 5-Methylisoxazole Substituted 1,2,4-Triazole." Journal of the Chinese Chemical Society 54, no. 3 (2007): 795–801. http://dx.doi.org/10.1002/jccs.200700115.

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40

LIFSHITZ, A., and D. WOHLFEILER. "ChemInform Abstract: Thermal Decomposition of 5-Methylisoxazole. Experimental and Modeling Study." ChemInform 23, no. 51 (1992): no. http://dx.doi.org/10.1002/chin.199251086.

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41

Kumari, Sudesh, M. Rajeswari, and Jitender M. Khurana. "A Green Approach for the Synthesis of Novel 7,11-Dihydro-6H-chromeno[3,4-e]isoxazolo[5,4-b]pyridin-6-one Derivatives Using Acidic Ionic Liquid [C4mim][HSO4]." Australian Journal of Chemistry 69, no. 9 (2016): 1049. http://dx.doi.org/10.1071/ch16014.

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A multicomponent reaction capable of affording a wide range of novel 7,11-dihydro-6H-chromeno[3,4-e]isoxazolo[5,4-b]pyridin-6-one derivatives via one-pot three-component condensation of 4-hydroxycoumarin, aromatic aldehydes, and 5-amino-3-methylisoxazole in ionic liquid 1-butyl-3-methylimidazolium hydrogen sulfate ([C4mim][HSO4]) is reported. Structures have been confirmed by spectral and X-ray studies. Crystal packing of 4b has also been reported. Green solvent, short reaction time, easy workup, and high yields are the salient features of the present protocol.

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42

Murlykina, Maryna V., Maryna N. Kornet, Sergey M. Desenko, et al. "New tricks of well-known aminoazoles in isocyanide-based multicomponent reactions and antibacterial activity of the compounds synthesized." Beilstein Journal of Organic Chemistry 13 (May 31, 2017): 1050–63. http://dx.doi.org/10.3762/bjoc.13.104.

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The well-known aminoazoles, 3-amino-5-methylisoxazole and 5-amino-N-aryl-1H-pyrazole-4-carboxamides, were studied as an amine component in Ugi and Groebke–Blackburn–Bienaymé multicomponent reactions. The first example of an application of aminoazoles in an Ugi four-component reaction was discovered and novel features of a Groebke–Blackburn–Bienaymé cyclocondensation are established and discussed. The heterocycles obtained were evaluated for their antibacterial activity and several of them demonstrated a weak antimicrobial effect, but for most of the compounds a 30–50% increase in biomass of Gr

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43

Thomas, Gareth M., and Richard L. Huganir. "Palmitoylation-dependent regulation of glutamate receptors and their PDZ domain-containing partners." Biochemical Society Transactions 41, no. 1 (2013): 72–78. http://dx.doi.org/10.1042/bst20120223.

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In recent years, it has become clear that both AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid)- and NMDA (N-methyl-D-aspartate)-type glutamate receptors, and many of their interacting partners, are palmitoylated proteins. Interfering with palmitoylation dramatically affects receptor trafficking and distribution and, in turn, can profoundly alter synaptic transmission. Increased knowledge of synaptic palmitoylation not only will aid our understanding of physiological neuronal regulation, but also may provide insights into, and even novel treatments for, neuropathological conditions.

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44

Horn, E., A. Horiuchi, M. Yamanaka, M. Murakami, and C. A. Horiuchi. "Crystal structure of cis-dichlorobis(5-methylisoxazole)platinum(II), PtCl2(C4H5NO)2." Zeitschrift für Kristallographie - New Crystal Structures 220, no. 1-4 (2005): 249–50. http://dx.doi.org/10.1524/ncrs.2005.220.14.249.

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45

Dupont, L., M. Kohl, and R. Lejeune. "tert-Butyl 3-[4-(2-Bromoethoxy)-3-chlorophenyl]-5-methylisoxazole-4-carboxylate." Acta Crystallographica Section C Crystal Structure Communications 54, no. 12 (1998): 1957–59. http://dx.doi.org/10.1107/s0108270198009482.

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46

Lee, Shi Yong, Bum Sung Lee, and Dong Young Oh. "ChemInform Abstract: Preparation, Alkylation, and Olefination Reaction of 5-Phosphonomethyl-3-methylisoxazole." ChemInform 31, no. 11 (2010): no. http://dx.doi.org/10.1002/chin.200011121.

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47

Carney, Paul R. "Rasmussen's Syndrome: Intractable Epilepsy and Progressive Neurological Deterioration From a Unilateral Central Nervous System Disease." CNS Spectrums 6, no. 5 (2001): 398,409–416. http://dx.doi.org/10.1017/s1092852900021775.

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AbstractRasmussen's syndrome (chronic encephalitis with epilepsy) is a rare neurological disorder of unknown cause characterized by severe epilepsy, hemiplegia, dementia, and inflammation of the brain, and progressive functional and structural destruction of a single cerebral hemisphere. While one mechanism underlying the pathogenesis of Rasmussens encephalitis has been hypothesized to be mediated by production of excitotoxic GluR3 autoantibodies to the a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor, other neuropathological etiologies have also been indicated. Proposed th

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48

Antonini, Cosimo, Franca M. Cordero, and Fabrizio Machetti. "5-(Benzoyloxymethyl)isoxazole-3-carboxylic Acid Ethyl Ester." Molbank 2024, no. 1 (2024): M1762. http://dx.doi.org/10.3390/m1762.

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We describe here the palladium hydrogenation of ethyl 5-(benzoyloxymethyl)isoxazole-3-carboxylate. The presence of two reducible sites in the molecule, namely the benzylic-like position and the isoxazole N–O bond, creates a possible competition. The results show that under the applied conditions, ethyl (Z)-2-amino-4-oxo-2-pentanoate is obtained as the only product. Accordingly, a domino process occurs, consisting of deoxygenation to the 5-methylisoxazole derivative followed by reductive opening of the isoxazole ring. The isoxazole substrate was prepared by NaOH-catalyzed cycloaddition-condensa

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Ganesh, Neenu, Gurubasavarj V. Pujar, and Bharat K. Inturi. "Synthesis and Evaluation of New 5-methylisoxazole-3-carboxamide Derivatives as Antitubercular Agents." Anti-Infective Agents 13, no. 2 (2015): 114–22. http://dx.doi.org/10.2174/2211352513666150326004534.

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50

Peng, Lv. "Design, synthesis, and in vitro activity of methylisoxazole/isothiazole amides as BACE1 inhibitors." Journal of Chinese Pharmaceutical Sciences 27, no. 3 (2018): 143–58. http://dx.doi.org/10.5246/jcps.2018.03.016.

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