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Journal articles on the topic 'Methylspiro'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Henao, J. A., A. Palma, V. V. Kouznetsov, and J. M. Delgado. "X-ray powder diffraction data for two new N-substituted 3,4-dihydrospiro-2(1H) quinolines." Powder Diffraction 14, no. 4 (1999): 249–52. http://dx.doi.org/10.1017/s0885715600010617.

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The X-ray powder diffraction patterns for two N-substituted tetrahydroquinolines are reported. N-(α-Chloroacetyl)-6-methoxy-3,4-dihydro-4-methylspiro[cyclohexane-1′,2(1H)quinoline], C18H24ClNO2, and N-(α-chloroacetyl)-6-chloro-3,4-dihydro-4-methylspiro[cyclohexane-1′,2(1H)-quinoline], C17H21Cl2NO are monoclinic, with refined unit cell parameters a=1.4471(3), b=0.9600(4), c=1.1948(3) nm, β=93.21(2)°, V=1.6573(6) nm3, Z=4, Dx=1.29 gcm−3, and a=1.4487(3), b=0.9878(2), c=1.1390(2) nm, β=91.66(2)°, V=1.6294(4) nm3, Z=4, and Dx=1.32 gcm−3, respectively, with space group P21/n (No. 14).Key words: pow

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2

Ashok, D., E. V. L. Madhuri, M. Sarasija, et al. "Synthesis, biological evaluation and molecular docking of spirofurochromanone derivatives as anti-inflammatory and antioxidant agents." RSC Advances 7, no. 41 (2017): 25710–24. http://dx.doi.org/10.1039/c7ra01550j.

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A series of 2′-substituted-3′-methylspiro[cyclohexane-1,7′-furo[3,2-g]chroman]-5′(7′H)-one, 5a–i and 7a–u have been synthesized using an eco-friendly approach with good anti-inflammatory and antioxidant activity.

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3

Katayama, Shintaro, and Hiroshi Nishino. "Manganese(III)-Based Oxidative Cyclization of N-Aryl-2-oxocycloalkane-1-carboxamides: Synthesis of Spiroindolinones." Synthesis 51, no. 17 (2019): 3277–86. http://dx.doi.org/10.1055/s-0037-1611563.

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The Mn(III)-based oxidative cyclization of twenty-five N-aryl-2-oxocycloalkane-1-carboxamides is investigated. The reactions progress efficiently to give the desired spiro[cycloalkane-1,3′-indoline]-2,2′-diones in high to quantitative yields. The easy conversion of the carbonyl functional group of one of the indoline products, 1′-methylspiro[cyclohexane-1,3′-indoline]-2,2′-dione, is also demonstrated.

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4

Kuznetsov, V. V., A. R. Pal'ma, M. Fernandes, et al. "Bromine-substituted 1,2,3,4-tetrahydro-4-methylspiro[quinoline-2-cyclohexanes]." Chemistry of Heterocyclic Compounds 27, no. 10 (1991): 1080–83. http://dx.doi.org/10.1007/bf00486802.

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5

KUZNETSOV, V. V., A. R. PAL'MA, M. FERNANDEZ, et al. "ChemInform Abstract: Bromo-Substituted 1,2,3,4-Tetrahydro-4-methylspiro(quinoline-2- cyclohexanes)." ChemInform 24, no. 14 (2010): no. http://dx.doi.org/10.1002/chin.199314191.

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6

Hamdouchi, C., M. Topolski, V. Goedken, and H. M. Walborsky. "Surface nature of Grignard reagent formation. Chiral 1-methylspiro[2.5]octylmagnesium bromide." Journal of Organic Chemistry 58, no. 11 (1993): 3148–55. http://dx.doi.org/10.1021/jo00063a040.

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7

Kolocouris, Antonios, Emmanuel Mikros, and Nicolas Kolocouris. "Stereodynamics of ring and nitrogen inversion in spiroheterocycles. Conformational analysis of N-methylspiro[morpholine-3,2′-adamantane] and N-methylspiro[piperidine-2,2′-adamantane] using NMR spectroscopy and theoretical calculations." Journal of the Chemical Society, Perkin Transactions 2, no. 7 (1998): 1701–8. http://dx.doi.org/10.1039/a705868c.

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8

Phong Vo, Phu, Hoan Ngoc Doan, Kenji Kinashi, Wataru Sakai, Naoto Tsutsumi, and Dai Phu Huynh. "X-ray Visualization and Quantification Using Fibrous Color Dosimeter Based on Leuco Dye." Applied Sciences 10, no. 11 (2020): 3798. http://dx.doi.org/10.3390/app10113798.

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A polystyrene (PS)-based fibrous color dosimeter, comprising a color former based on 2-(phenylamino)-6-(dipentylamino)-3-methylspiro[9H-xanthene-9,3′-phthalide] (Black305) fluoran leuco dye and a 2-(4-methoxystyryl)-4,6-bis(trichloromethyl)-1,3,5-triazine (MBTT) photoacid generator, was developed for visual detection of X-ray doses of 15 Gy and higher. The composite fiber was produced by using a centrifugal spinning method, and the obtained composite fiber exhibited a stable and uniform morphology with a fiber diameter of 10 μm or less and had sufficient mechanical strength. As an example of p

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9

Subbiahpandi, A., D. Velmurugan, K. Ravikumar, R. R. Durga, and R. Raghunathan. "3-Acetyl-4-furyl-1-methylspiro[pyrrolidine-2,2′-indol]-2′(3′H)-one." Acta Crystallographica Section E Structure Reports Online 62, no. 5 (2006): o1964—o1965. http://dx.doi.org/10.1107/s1600536806013353.

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In the title compound, C18H18N2O3, the central pyrrolidine ring adopts a half-chair conformation. The furan ring is almost perpendicular to the oxindole system. Intermolecular C—H...O and N—H...N hydrogen bonds link the molecules into ribbons running along the b-axis direction.

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10

Srinivasan, T., S. Suhitha, S. Purushothaman, R. Raghunathan, and D. Velmurugan. "3′-(4-Chlorobenzoyl)-4′-(4-chlorophenyl)-1′-methylspiro[indoline-3,2′-pyrrolidin]-2-one." Acta Crystallographica Section E Structure Reports Online 67, no. 11 (2011): o3128. http://dx.doi.org/10.1107/s1600536811044618.

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11

Lakshmi, S., K. Subramanian, G. Koellner, Th Steiner та K. Rajagopalan. "7β-Hydroxy-7α-(3-propargyl)-3-methylspiro[5.5]undec-2-en-1-one". Acta Crystallographica Section C Crystal Structure Communications 52, № 2 (1996): 405–7. http://dx.doi.org/10.1107/s0108270195011334.

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12

HAMDOUCHI, C., M. TOPOLSKI, V. GOEDKEN, and H. M. WALBORSKY. "ChemInform Abstract: Surface Nature of Grignard Reagent Formation. Chiral 1-Methylspiro(2.5) octylmagnesium Bromide." ChemInform 24, no. 38 (2010): no. http://dx.doi.org/10.1002/chin.199338280.

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13

Benito, Y., L. Canoira, N. Martinez-Lopez, J. G. Rodriguez, and F. Temprano. "Synthesis of 1′-methylspiro[3H-indole-3,n'-piperidines] from 1-methyl-n-piperidinecarbaldehydes." Journal of Heterocyclic Chemistry 24, no. 3 (1987): 623–28. http://dx.doi.org/10.1002/jhet.5570240315.

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14

Satis Kumar, B. K., D. Gayathri, D. Velmurugan, K. Ravikumar, and A. R. Sureshbabu. "4′-Ferrocenyl-3′-(4-methoxybenzoyl)-1′-methylspiro[1H-indole-3(2H),2′-pyrrolidin]-2-one." Acta Crystallographica Section E Structure Reports Online 63, no. 5 (2007): m1287—m1289. http://dx.doi.org/10.1107/s1600536807016182.

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15

Liu, Jun-Liang, Zhi-Yu Hu, and Qing-Yan Xu. "3′-(3-Hydroxyphenyl)-4-methylspiro[benzo[e][1,4]diazepine-3,2′-oxirane]-2,5(1H,4H)-dione." Acta Crystallographica Section E Structure Reports Online 67, no. 7 (2011): o1670. http://dx.doi.org/10.1107/s1600536811022161.

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16

Gonzalo Rodríguez, J., Anahí Urrutia, Isabel Fonseca, and Julia Sanz. "Synthesis reactivity and molecular structure of 2′-methylspiro[cyclohexane-1,3′-3H-indole]chromium tricarbonyl complex." Journal of Organometallic Chemistry 522, no. 2 (1996): 231–35. http://dx.doi.org/10.1016/0022-328x(96)06283-3.

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17

Kuznetsov, V. V., A. Pal'ma, A. �. Aliev, N. S. Prostakov, and A. V. Varlamov. "Synthesis of N-alkyl(acyl)-1,2,3,4-tetrahydro-4-methylspiro [quinoline-2-cyclohexanes] and their conversions." Chemistry of Heterocyclic Compounds 29, no. 6 (1993): 676–83. http://dx.doi.org/10.1007/bf00531546.

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18

Reimann, Eberhard, Johann Speckbacher, and Hermann Lotter. "Intramolekulare Aromatenalkylierungen, 18. Mitt. Synthese von 3,4-Dihydro-1′-methylspiro[naphthalin-1(2H), 4′-piperidinen]." Archiv der Pharmazie 320, no. 5 (1987): 385–93. http://dx.doi.org/10.1002/ardp.19873200502.

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19

Reimann, Eberhard, and Johann Speckbacher. "Intramolekulare Aromatenalkylierungen, 26. Mitt.: Synthese von 3,4-Dihydro-1′-methylspiro[naphthalin-1(2H),2′-piperidin]." Archiv der Pharmazie 322, no. 12 (1989): 889–92. http://dx.doi.org/10.1002/ardp.19893221210.

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20

Gataullin, R. R., I. S. Afon'kin, A. A. Fatykhov, L. V. Spirikhin, and I. B. Abdrakhmanov. "ChemInform Abstract: Synthesis of 2′-Bromo-8-methylspiro(4H-3,1-benzooxazine-4,1′-cyclopentan)-2(1H)-one and 2-Amino-2′-bromo-8-methylspiro(4H-3,1-benzooxazine-4,1′-cyclopentane) from 6-(Cyclopent-1-enyl)-2-methylaniline." ChemInform 33, no. 43 (2010): no. http://dx.doi.org/10.1002/chin.200243196.

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21

Chamontin, K., V. Lokshin, R. Guglielmetti, A. Samat, and G. Pèpe. "4-Methylspiro[4-azahomoadamantane-5,3'-[3'H]naphth[2,1-b][1,4]oxazine], a New Photochromic Spirooxazine." Acta Crystallographica Section C Crystal Structure Communications 54, no. 5 (1998): 670–72. http://dx.doi.org/10.1107/s0108270197017447.

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22

Reimann, Eberhard, and Johann Speckbacher. "Intramolekulare Aromatenalkylierungen, 27. Mitt.1): Synthese von 3,4-Dihydro-1′-methylspiro [naphthalin-1(2H), 3′-piperidin]." Archiv der Pharmazie 323, no. 1 (1990): 13–15. http://dx.doi.org/10.1002/ardp.19903230105.

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23

Nordvall, Gunnar, Staffan Sundquist, Gunilla Glas, Adolf Gogoll, Lisbeth Nilvebrant, and Uli Hacksell. "Analogs of the muscarinic agent 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]: synthesis and pharmacology." Journal of Medicinal Chemistry 35, no. 9 (1992): 1541–50. http://dx.doi.org/10.1021/jm00087a007.

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24

KUZNETSOV, V. V., A. PAL'MA, A. E. ALIEV, N. S. PROSTAKOV, and A. V. VARLAMOV. "ChemInform Abstract: Synthesis of N-Alkyl(acyl)-1,2,3,4-tetrahydro-4-methylspiro(quinoline- 2-cyclohexanes) and Their Transformations." ChemInform 25, no. 15 (2010): no. http://dx.doi.org/10.1002/chin.199415195.

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25

Pèpe, G., P. Laréginie, A. Samat, R. Guglielmetti, and E. Zaballos. "8-Methylspiro(syn-10,11-benzo-8-azatricyclo[5.2.2.01,5]undec-10-ene)-9,3'-[3H]naphth[1,2-b][1,4]oxazine." Acta Crystallographica Section C Crystal Structure Communications 51, no. 8 (1995): 1617–19. http://dx.doi.org/10.1107/s0108270195000205.

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26

Steiner, Bohumil, Jan Gajdos, and Miroslav Koos. "(4R)-1'-Acetyl-2,3-O-isopropylidene-methylspiro [4,6-dideoxy-ß-D-ribo-hexopyranosid-4,5'-imidazolidin]-2',4'-dione." Molecules 5, no. 12 (2000): M140. http://dx.doi.org/10.3390/m140.

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27

Castaldi, Graziano, Pietro Allegrini, Roberto Fusco, Luca Longo, and Vincenzo Malatesta. "New thermo and photochromic 10-methylspiro{dibenzo[b,f][1,4]oxazepino-11,3′-3H-naphtho[2,1-b]-1,4-oxazine}." J. Chem. Soc., Chem. Commun., no. 18 (1991): 1257–58. http://dx.doi.org/10.1039/c39910001257.

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28

CHAMONTIN, K., V. LOKSHIN, R. GUGLIELMETTI, A. SAMAT, and G. PEPE. "ChemInform Abstract: 4-Methylspiro[4-azahomoadamantane-5,3′-[3′H]naphth[2,1-b][1,4]oxazine], a New Photochromic Spirooxazine." ChemInform 29, no. 37 (2010): no. http://dx.doi.org/10.1002/chin.199837028.

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29

Boitsov, Vitali M., Alexander V. Stepakov, Siqi Wang, et al. "Construction of Spiro[3-azabicyclo[3.1.0]hexanes] via 1,3-Dipolar Cycloaddition of 1,2-Diphenylcyclopropenes to Ninhydrin-Derived Azomethine Ylides." Synthesis 53, no. 12 (2021): 2114–32. http://dx.doi.org/10.1055/a-1360-9716.

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AbstractThe multi-component 1,3-dipolar cycloaddition of ninhydrin, α-amino acids (or peptides), and cyclopropenes for the synthesis of spirocyclic heterocycles containing both 3-azabicyclo[3.1.0]hexane and 2H-indene-1,3-dione motifs has been developed. This method provides easy access to 3-azabicyclo[3.1.0]hexane-2,2′-indenes with complete stereoselectivity and a high degree of atom economy under mild reaction conditions. A broad range of cyclopropenes and α-amino acids have been found to be compatible with the present protocol, which offers an opportunity to create a new library of biologica

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30

Chandralekha, Kuppan, Adukamparai Rajukrishnan Sureshbabu, Deivasigamani Gavaskar, and Srinivasakannan Lakshmi. "Crystal structure of methyl 3′-benzamido-4′-(4-methoxyphenyl)-1′-methylspiro[indeno[1,2-b]quinoxaline-11,2′-pyrrolidine]-3′-carboxylate." Acta Crystallographica Section E Crystallographic Communications 72, no. 9 (2016): 1257–59. http://dx.doi.org/10.1107/s2056989016012469.

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In the title compound, C35H30N4O3, the spiro C atom connects the five-membered pyrrolidine ring and the indenoquinoxaline ring system. The pyrrolidine ring adopts a twist conformation. An intramolecular N—H...N interaction between the amino group and the pyrazine ring is observed. In the crystal, molecules are linked by a pairs of C—H...O hydrogen bonds, forming inversion dimers.

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31

Singh, Girija S., and Patrick Luntha. "Synthesis and antimicrobial activity of new 1-alkyl/cyclohexyl-3,3-diaryl-1′-methylspiro[azetidine-2,3′-indoline]-2′,4-diones." European Journal of Medicinal Chemistry 44, no. 5 (2009): 2265–69. http://dx.doi.org/10.1016/j.ejmech.2008.06.007.

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32

Bartolo, Nicole D. "Preparation of a Radical Clocks Bearing Carbonyl Groups: Synthesis of N-Methoxy-N-methylspiro[cyclopropane-1,9'-fluorene]-2-carboxamide." Organic Syntheses 101 (2024): 61–80. http://dx.doi.org/10.15227/orgsyn.101.0061.

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33

Almansour, Abdulrahman I., Raju Suresh Kumar, Natarajan Arumugam, R. Vishnupriya, and J. Suresh. "5-Methylspiro[indoline-3,7′-[6H,7H,8H]pyrano[3,2-c:5,6-c′]di[1]benzopyran]-2,6′,8′-trione chloroform hemisolvate." Acta Crystallographica Section E Structure Reports Online 68, no. 4 (2012): o1194. http://dx.doi.org/10.1107/s1600536812012020.

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In the title compound, C27H15NO6·0.5CHCl3, the central pyran ring and both the benzopyran systems are planar, with the dihedral angle between the outer rings being 3.24 (6)°. The indolin-2-one system is in a perpendicular configuration with respect to the pyran ring [dihedral angle = 87.58 (2)°]. Supramolecular layers in theacplane are formed in the crystal structure whereby inversion-related molecules are connected by N—H...O hydrogen bonds. These are further linked by C—H...O interactions, forming a supramolecular layer in theacplane. Disordered CHCl3solvent in the structure was modelled wit

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34

Efange, Simon M. N., Ashok P. Kamath, Anil B. Khare, Mei-Ping Kung, Robert H. Mach та Stanley M. Parsons. "N-Hydroxyalkyl Derivatives of 3β-Phenyltropane and 1-Methylspiro[1H-indoline-3,4‘-piperidine]: Vesamicol Analogues with Affinity for Monoamine Transporters". Journal of Medicinal Chemistry 40, № 24 (1997): 3905–14. http://dx.doi.org/10.1021/jm970326r.

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35

Saunders, John, Graham A. Showell, Raymond Baker, et al. "Synthesis and characterization of all four isomers of the muscarinic agonist, 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]." Journal of Medicinal Chemistry 30, no. 6 (1987): 969–75. http://dx.doi.org/10.1021/jm00389a003.

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36

Singh, Girija S., and Patrick M. Luntha. "Unanticipated products from reductive and oxidative cleavages of 1-substituted 3,3-diphenyl-1′-methylspiro[azetidine-2,3′-indoline]-2′,4-diones." Journal of Heterocyclic Chemistry 48, no. 6 (2011): 1312–16. http://dx.doi.org/10.1002/jhet.731.

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37

Singh, Girija S., та Boycie J. Mmolotsi. "Reactions of α-diazoketones with indolinone imines: Synthesis of new 1,3,3-triaryl-1′-methylspiro[azetidine-2,3′-indoline]-2′,4-diones". Journal of Heterocyclic Chemistry 43, № 6 (2006): 1665–68. http://dx.doi.org/10.1002/jhet.5570430636.

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38

CASTALDI, G., P. ALLEGRINI, R. FUSCO, L. LONGO, and V. MALATESTA. "ChemInform Abstract: New Thermo- and Photochromic 10-Methylspiro(dibenzo(b,f)(1,4)oxazepino- 11,3′-3H-naphtho(2,1-b)-1,4-oxazine)." ChemInform 23, no. 13 (2010): no. http://dx.doi.org/10.1002/chin.199213245.

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39

Yuan, Qing, and Ming Lei. "(1′S,2′S,5′R)-3-(2-Bromopropionyl)-2′-isopropyl-5′-methylspiro[2H-1,3-benzoxazine-2,1′-cyclohexan]-4(3H)-one." Acta Crystallographica Section E Structure Reports Online 62, no. 7 (2006): o3011—o3012. http://dx.doi.org/10.1107/s1600536806017296.

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The absolute configuration of the title compound, C20H26BrNO3, was determined from both the synthetic precursor and anomalous scattering effects. In the crystal structure, non-classical C—H...O hydrogen bonds link the molecules into a sheet parallel to the b axis.

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40

Horie, T., M. Kitada, H. Yoshioka, Y. Kanakubo, and T. Omura. "6-Fluoro-2-methylspiro(chroman-4,4'-imidazolidine)-2',5'-dione and related compounds as inducers of monooxygenase in rat liver microsomes." Drug Metabolism and Disposition 15, no. 4 (1987): 560–64. https://doi.org/10.1016/s0090-9556(25)06783-2.

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41

Reboul, J. P., A. Samat, P. Laréginie, V. Lokshin, R. Guglielmetti, and G. Pèpe. "Photochromic 8-Ethoxy-2-methylspiro(syn-5,6-benzo-2-azabicyclo[2.2.2]oct-5-ene-3,3'-[3H]naphth[2,1-b][1,4]oxazine)." Acta Crystallographica Section C Crystal Structure Communications 51, no. 8 (1995): 1614–17. http://dx.doi.org/10.1107/s0108270195000229.

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42

Ackroyd, John, Martin Karpf, and Andr� S. Dreiding. "Investigation of the Cyclopentenone Formationvia the ?-Alkynone Cyclisation: Synthesis of the Acorone Intermediate 8-Methylspiro[4.5]deca-3,7-dien-2-one." Helvetica Chimica Acta 68, no. 2 (1985): 338–44. http://dx.doi.org/10.1002/hlca.19850680208.

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43

Reimann, Eberhard, Johann Speckbacher, and Jürgen Schünemann. "Intramolekulare Aromatenalkylierungen, 28.Mitt.1): Synthese und pharmakologische Prüfung homologer und hydroxylierter 3,4-Dihydro-1'-methylspiro[naphthalin-1(2H),4'-piperidine]." Archiv der Pharmazie 323, no. 1 (1990): 35–39. http://dx.doi.org/10.1002/ardp.19903230110.

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44

Singh, Girija S., and Patrick M. Luntha. "ChemInform Abstract: Unanticipated Products from Reductive and Oxidative Cleavages of 1-Substituted 3,3-Diphenyl-1′-methylspiro[azetidine-2,3′-indoline]-2′,4-diones." ChemInform 43, no. 16 (2012): no. http://dx.doi.org/10.1002/chin.201216110.

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45

Yamagishi, Masafumi, Yoshihisa Yamada, Kenichi Ozaki, et al. "Preparation of optically pure 3'-methylspiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-trione by combination of optical resolution and racemization." Journal of Organic Chemistry 57, no. 5 (1992): 1568–71. http://dx.doi.org/10.1021/jo00031a043.

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46

Vennila, K. N., M. Sankaran, P. S. Mohan, and D. Velmurugan. "(1R*,3′S*,4′R*)-4′-(4-Chlorophenyl)-3′-[(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]-1′-methylspiro[acenaphthylene-1,2′-pyrrolidin]-2-one." Acta Crystallographica Section E Structure Reports Online 67, no. 12 (2011): o3376—o3377. http://dx.doi.org/10.1107/s1600536811048896.

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47

Declercq, J. P., G. Germain, M. van MEERSSCHE, A. Devreese, P. De Clerco та M. Vandewalle. "X-ray diffraction study of (±)-decahydro-9-hydroxy-9-methylspiro|azuleno| 4,5-b|furan-6(2h),2'-|1,3|dioxolan|-2-one (3aβ, 6aα, 9β, 9aβ, 9bα)". Bulletin des Sociétés Chimiques Belges 90, № 9 (2010): 899–903. http://dx.doi.org/10.1002/bscb.19810900904.

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48

Wang, Mingan, Manoj K. Mishra, Wenjun Zhu, and Peter F. Kador. "Spectral assignments for the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4,4′-imidazoline]-2′,5′-dione and its synthetic intermediates." Magnetic Resonance in Chemistry 43, no. 12 (2005): 1008–11. http://dx.doi.org/10.1002/mrc.1697.

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Hung, Tran Thanh, Pham Thu Trang, Hoang Viet, Nguyen Thi My Lan, Luong Thi My Ngan, and Tran Trung Hieu. "In vitro antimicrobial activity of hydrosol from Litsea cubeba (Lour.) Pers. against Helicobacter pylori and Candida albicans." Biomedical Research and Therapy 7, no. 6 (2020): 3819–28. http://dx.doi.org/10.15419/bmrat.v7i6.610.

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Abstract:

Introduction: Helicobacter pylori and Candida albicans are classified as the most common pathogenic agents in humans. H. pylori is responsible for gastroduodenal diseases and greatly associated with gastric carcinogenesis, while C. albicans is the main cause of fungal urinary tract, genital yeast, and fungal skin infections. The increasing appearance of drug-resistant strains of H. pylori and C. albicans has made the treatment of the infections more serious. Hydrosols from plant steam distillation have been traditionally used in medicine, cosmetics, and culinary uses. They have been recently s

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Iga, Yoshinori, Hirohiko Arisawa, Nobuo Ogane, et al. "(±)-cis-2-Methylspiro[1,3-oxathiolane-5,3-quinuclidine] Hydrochloride, Hemihydrate (SNI-2011, Cevimeline Hydrochloride) Induces Saliva and Tear Secretions in Rats and Mice: The Role of Muscarinic Acetylcholine Receptors." Japanese Journal of Pharmacology 78, no. 3 (1998): 373–80. http://dx.doi.org/10.1254/jjp.78.373.

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