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Dissertations / Theses on the topic 'Methyltransferase'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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1

Vidgren, Jukka. "Crystallographic studies on drug receptors catechol O-methyltransferase and carbonic anhydrase /." Lund : Dept. of Molecular Biophysics, Lund University, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39725795.html.

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2

Bonnist, Eleanor Y. M. "The investigation of DNA-methyltransferase interactions in the adenine methyltransferases using the time-resolved fluorescence of 2-aminopurine." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/3175.

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The time-resolved fluorescence of 2-aminopurine (2AP) has been used to investigate DNA base flipping by the adenine methyltransferases and to study aspects of the DNA-enzyme interaction. 2AP is an excellent fluorophore to probe base flipping in the adenine methyltransferases because, as demonstrated in the present work on M.TaqI, the 2AP is delivered into the same position inside the enzyme as the natural target adenine and with the same orientation that prepares the adenine for enzyme catalysis. 2AP emits two types of fluorescence when in DNA. The first is the well-known 370-nm emission, whic
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3

May, Kyle M. "Investigation of Protein Dynamics and Communication in Adomet-Dependent Methyltransferases: Non-Ribosomal Peptide Synthetase and Protein Arginine Methyltransferase." DigitalCommons@USU, 2019. https://digitalcommons.usu.edu/etd/7550.

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For many enzymes to function correctly they must have the freedom to display a level of dynamics or communication during their catalytic cycle. The effects that protein dynamics and communication can have are wide ranging, from changes in substrate specificity or product profiles, to speed of reaction or switching activity on or off. This project investigates the protein dynamics and communication in two separate systems, a non-ribosomal peptide synthetase (NRPS), and a protein arginine methyltransferase (PRMT). PRMT1, the enzyme responsible for 80% of arginine methylation in humans, has been
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4

Deng, Jing. "Multiple isoforms of rat DNA methyltransferase are encoded by the cytosine DNA methyltransferase gene and differentially expressed." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0020/NQ55320.pdf.

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5

Deng, Jing 1966. "Multiple isoforms of rat DNA methyltransferase are encoded by the cytosine DNA methyltransferase gene and differentially expressed." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36001.

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Tissue- and gene-specific DNA methylation patterns are hallmarks of vertebrate genomes and have been suggested to play a critical role in regulating genome functions. There is remarkable diversity of DNA methylation patterns. However, it is yet unclear what is responsible for this diversity.<br>In this dissertation, Chapters Two and Three, we test the hypothesis that multiple forms of DNA (cytosine-5) methyltransferase are generated from a single DNA methyltransferase gene (Dnmt1) in vertebrates in vivo. We show that diversification of the N-terminus of Dnmt1 occurs by two mechanisms, multiple
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6

Frauer, Carina. "Studies of mechanisms controlling DNA methyltransferase 1." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-121294.

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7

Lanouette, Sylvain. "Characterization of the Protein Lysine Methyltransferase SMYD2." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32467.

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Our understanding of protein lysine methyltransferases and their substrates remains limited despite their importance as regulators of the proteome. The SMYD (SET and MYND domain) methyltransferase family plays pivotal roles in various cellular processes, including transcriptional regulation and embryonic development. Among them, SMYD2 is associated with oesophageal squamous cell carcinoma, bladder cancer and leukemia as well as with embryonic development. Initially identified as a histone methyltransferase, SMYD2 was later reported to methylate p53, the retinoblastoma protein pRb and the estro
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8

Jue, Kathleen. "Regulation of DNA methyltransferase expression during spermatogenesis." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22746.

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Patterns of methylation at the 5-position of cytosine are postulated to be involved in several mammalian processes such as the regulation of gene expression, genomic imprinting and X chromosome inactivation. Disruptions in methylation patterns affect embryonic development and are involved in carcinogenesis, indicating the importance of regulating these patterns. The establishment of methylation patterns is believed to be initiated during gametogenesis and continue during early embryonic development. DNA (cytosine-5)-methyltransferase (EC2.1.1.37) (DNA methyltransferase) is the only known mamma
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9

Farrell, Sarah Marie. "The magnetoencephalographic signature of catechol-O-methyltransferase." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:bb375074-7912-4f8b-b123-975dff7d88e0.

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Catechol-O-methyltransferase (COMT) metabolizes catechols, notably dopamine. The COMT Val158Met polymorphism influences its enzyme activity, and multiple neural correlates of this genotype on dopaminergic phenotypes have been reported, particularly with regards to working memory. COMT activity can also be regulated pharmacologically by COMT inhibitors. The ‘inverted-U’ relationship between dopamine signalling and cognitive performance predicts that the effects of COMT inhibition will differ according to COMT genotype. The goal of this thesis was to better understand COMT’s impact on brain func
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10

McKelvie, Jennifer C. "Novel antibiotics from DNA adenine methyltransferase inhibitors." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/341769/.

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The re-emergence of plague as a world-wide health concern and the potential risk posed by bioterrorism has led to an increased interest in available treatments for the disease. The bacterial DNA adenine-N6 methyltransferase, Dam, is involved in the regulation of a range of pathogenic bacteria and has been validated as a target for the development of antimicrobial agents with activity against Yersinia pestis, the causative agent of plague. The lack of a functionally similar enzyme in mammals suggests that highly selective Dam inhibitors could be developed. A coupled, real-time break light Dam a
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11

Maynard-Smith, Michael David. "Novel antibiotics from DNA adenine methyltransferase inhibitors." Thesis, University of Southampton, 2009. https://eprints.soton.ac.uk/202481/.

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DNA adenine methylation plays a role in several core bacterial processes, including DNA mismatch repair, the timing of DNA replication and gene expression. The dependence of bacterial virulence on the activity of Dam, an adenine methyltransferase, makes it an attractive target for novel antibiotics. Dam from Yersinia pestis, the plague causing bacteria, was expressed and purified by nickel affinity chromatography. A plasmid containing the methylation sensitive restriction endonuclease dpnI gene was assembled. DpnI was expressed and purified by nickel affinity chromatography. A Y. pestis Dam ac
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12

Bai, Shoumei. "Role of DNA methyltransferase 3B in neuronal cell differentation." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1125702764.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xviii, 157 p.; also includes graphics (some col.). Includes bibliographical references (p. 125-157). Available online via OhioLINK's ETD Center
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13

Blight, Sherry Kathleen. "Amber codon translation as pyrrolysine in Methanosarcina spp." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1149012579.

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14

Al-Swailem, Abdulaziz Mohammed A. "Error-prone repair induced by mutant DNA methyltransferases." Thesis, University of Sheffield, 1999. http://etheses.whiterose.ac.uk/14776/.

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Organisms utilise cytosine-5 DNA methylation to expand their repertoire of genetic transactions. Structural studies of DNA cytosine-5 methyltransferase have revealed that DNA methyltransferases incorporate nucleotide flipping into their catalytic cycle in order to access the otherwise buried pyrimidine ring from within duplex DNA. Interestingly, substituting the catalytic nucleophile Cys with Gly can produce cytotoxic forms of the bacterial methyltransferases and cause rearrangements in the DNA. In this study the generality of the cytotoxic effect has been studied on both mono and multi-specif
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15

Qin, Weihua. "Studies of interaction proteins controlling DNA methyltransferase 1." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-147692.

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16

Pinard, Marc. "Multitiered regulation of 5-cytosine DNA methyltransferase expression." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0017/NQ44554.pdf.

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17

Lindqvist, Malin. "Pharmacogenetic studies of thiopurines : focus on thiopurine methyltransferase /." Linköping : Linköpings universitet, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med893s.pdf.

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18

Morris, Stephanie A. Strahl Brian D. "Conservation and function of the histone methyltransferase Set2." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1253.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biochemistry and Biophysics." Discipline: Biochemistry and Biophysics; Department/School: Medicine.
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19

Zamiri, Maryam. "Synthesis of protein arginine N-methyltransferase 6 inhibitors." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43808.

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Protein arginine N-methyltransferases (PRMTs) are pertinent targets for drug discovery as their dysfunction is associated with a number of diseases such as cancers, cardiovascular diseases and viral pathogenesis. The precise role of PRMTs in the initiation, development, or progression of diseases is not known yet. Due to association of PRMT1 and 4 with transcriptional activation, the main focus of inhibitor discovery has been on these two enzymes. On the other hand, the goal of this study is to find a PRMT6 specific inhibitor. PRMT6 methylates DNA polymerase β, histones H3 and H4 and HIV pr
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20

Lindqvist, Appell Malin. "Pharmacogenetic studies of thiopurines : focus on thiopurine methyltransferase." Doctoral thesis, Linköpings universitet, Klinisk farmakologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-30560.

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Pharmacogenetics represents the study ofvariability in drug response due to genetic variations. The thiopurines (6-mercaptopurine, 6-thioguanine and azathioprine) are prodrugs which require metabolic transformation to exert effect. Thiopurines are used in inflammatory bowel disease, as maintenance treatment of childhood acute lymphoblastic leukaemia, and for immunosuppression after transplantation. The metabolism is complex and one important enzyme involved is thiopurine methyltransferase (TPMT). Inherited variation in TPMT activity is one factor responsible for individual differences in susce
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21

Rouleau, Julie. "Regulation of the mouse DNA methyltransferase gene expression." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29122.

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A hallmark of DNA methylation is the fact that 60 to 80% of CpG dinucleotide sequences in the vertebrate genome are methylated at the 5th-position of cytosine while the remaining unmethylated sequences are nonrandomly distributed throughout the genome generating a pattern of methylation that is both tissue and gene specific. Several lines of evidence suggest that methylation patterns correlate with the expression level of eukaryotic genes and that DNA methylation plays an important role in regulating the state of differentiation of mammalian cells. The methylation of DNA is catalyzed by the DN
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22

Hong, Wei. "Design and synthesis of protein arginine methyltransferase inhibitors." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/12835/.

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Biological methylation is defined as the transfer of a methyl group from S-adenosyl-L-methionine(SAM) to one of a wide range of potential acceptors such as DNA, RNA, protein, hormones and neurotransmitters. Protein arginine methylation is a common post-translational modification facilitated by protein arginine methyltransferases(e.g. PRMTI). The roles of these enzymes in vivo are currently poorly understood. The focus of the project is design and synthesis of PRMT inhibitors with the ultimate goal of evaluating their activities in cells. Preliminary work toward the synthesis of S-adenosyl-trif
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23

Green, Ian. "The biology of novel dual histone methyltransferase inhibitors." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/25763.

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Background: EZH2 is a histone methyltransferase (HKMT) responsible for the maintenance of epigenetic silencing of genes through maintenance of the repressive H3K27me3 mark and it is aberrantly regulated in numerous cancers, including breast cancer where it is linked to aggressive phenotypes and poor clinical outcomes. EHMT2 is a related HKMT responsible for gene silencing by mediating H3K9me3 levels. EHMT2 is also responsible for H3K27me1 and has been shown to physically interact with EZH2. Specific inhibitors of EZH2 are available and have been shown to be effective in cancers with EZH2 mutat
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24

Srimongkolpithak, Nitipol. "The search for novel histone lysine methyltransferase inhibitors." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/56104.

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Reversal of aberrant epigenetic silencing by small molecule inhibitors is of high interest in the fields of chemical biology and drug discovery. Full understanding of these processes is crucial for the development of truly epigenetic therapies. Histone lysine methyltransferases (HKMTs), including G9a and EZH2, are the key players in epigenetic regulation, and are involved in many diseases such as cancer. In 2009, the first substrate competitive G9a inhibitor, BIX-01294, was reported by screening a large chemical library, which paved the way for future HKMT drug discovery research. In our resea
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25

Wang, Sheng Verfasser], Oliver [Herausgeber] [Einsle, Roland [Sonstige] Schüle, Manfred [Sammler] Jung, Oliver [Akademischer Betreuer] Einsle, and Roland [Akademischer Betreuer] Schüle. "Structural insights into a novel histone methyltransferase - KMT9." Freiburg : Universität, 2019. http://d-nb.info/1224416538/34.

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26

Wang, Sheng [Verfasser], Oliver [Herausgeber] Einsle, Roland [Sonstige] Schüle, Manfred [Sammler] Jung, Oliver [Akademischer Betreuer] Einsle, and Roland [Akademischer Betreuer] Schüle. "Structural insights into a novel histone methyltransferase - KMT9." Freiburg : Universität, 2019. http://d-nb.info/1224416538/34.

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27

Monami, Amélie Joséphine. "Kupplung der DNA-Methyltransferase M.SssI mit Triplehelix-bildenden Oligodesoxynucleotiden." [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=983682801.

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28

Ridgway, Neale David. "Rat hepatic phosphatidylethanolamine N-methyltransferase : enzyme purification and characterization." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/29377.

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Phosphatidylethanolamine (PE) N-methyltransferase catalyzes the stepwise transfer of methyl groups from S-adenosyl-L-methionine (AdoMet) to the amino headgroup of PE. Successive methylation results in the formation of the two intermediates, phosphatidyl-N-monomethylethanolamine (PMME) and phosphatidyl-N, N-dimethylethanolamine (PDME), and the final product phosphatidylcholine (PC). PE N-methyltransferase is an integral membrane protein localized primarily in the endoplasmic reticulum (microsomal fraction) of liver. PE-, PMME- and PDME-dependent PE N-methyltransferase activities were purified f
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29

Pak, Laam. "Insights into a heteromeric protein arginine N-methyltransferase complex." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42123.

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Protein arginine N-methyltransferases (PRMTs) act in signaling pathways and gene expression by methylating arginine residues within target proteins. PRMT1 is responsible for most cellular arginine methylation activity and can work independently or in collaboration with other PRMTs. In this Ph.D. thesis I demonstrated an interaction between PRMT1 and -2 using co-immunoprecipitation and bimolecular fluorescence complementation (BiFC). As a result of this interaction, PRMT2 stimulated PRMT1 methyltransferase activity, affecting its apparent Vmax and Km values in vitro, and increasing the producti
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30

Zhang, Li. "DRMT4 (Drosophila arginine methyltransferase 4) : functions in Drosophila oogenesis." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80905.

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DRMT4 (Drosophila Arginine MethylTransferase 4) is an arginine methyltransferase in Drosophila (Boulanger et al. 2004). It shows the highest identities with mammalian PRMT4/CARM1 (Protein Arginine MethylTransferase 4) (59% identity, 75% similarity). HPLC analysis demonstrated that DRMT4 belongs to the type I class of methyltransferases (Boulanger et al. 2004), meaning that DRMT4 catalyzes asymmetrical dimethylarginine formation. A polyclonal antibody against DRMT4 was generated and used to study DRMT4 expression using western blots and immunostainings. In order to study DRMT4 function
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31

Townsend, Andrew Paul. "Nitrogen mustards as tools in determining methyltransferase substrate specificity." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517857.

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32

Cho, Er-Chieh. "The functional characterisation of arginine methyltransferase in cancer cells." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534151.

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33

Driskell, Iwona. "Functional roles of the histone methyltransferase Setd8 in skin." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648309.

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34

Al-Ghanim, Adel Abdullah. "Biochemical analysis of the recombinant multispecific DNA methyltransferase M.SPRI." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369942.

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35

Wand, Nathaniel Ovelin. "Methyltransferase-directed labelling for visualisation and identification of DNA." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8470/.

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New techniques for rapid identification of complex mixtures of viral and bacterial DNA and for visualising multi-copy plasmids in single bacterial cells have been developed using a combination of methyltransferase-directed labelling, molecular combing, and widefield microscopy. In Chapter 2 the protocol for methyltransferase-directed labelling was optimised. A maximum labelling efficiency of 50% (as measured by single molecule counting results) was obtained for Atto 647N-labelled pUC19. In Chapters 3 and 4 the optimised labelling protocol was used to label genomic DNA for optical mapping and i
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36

Wilkinson, Caroline R. M. "Analysis of a DNA methyltransferase homologue in fission yeast." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/11573.

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The methylation of DNA is a widespread phenomenon found in organisms ranging from bacteria to mammals. Methylation of cytosine at the 5-position is the most common form of this modification and is catalyzed by a conserved family of enzymes. In bacteria, methylation of DNA forms part of the restricted-modification system. The role of DNA methylation in eukaryotes is less clearly defined but it has been implicated in process such as the control of gene expression and the organization of chromatin structure. Progress in the understanding of DNA methylation could be greatly enhanced by the opportu
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37

Cherblanc, Fanny. "Synthesis and biological evaluation of histone lysine methyltransferase inhibitors." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/23793.

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The epigenetic component of cancer is now well-established and epigenetic therapeutics targeting histone deacetylase and DNA methyltransferase enzymes have received FDA approval. Histone lysine methyltransferases (HKMTs) are a new and promising epigenetic target class for cancer treatment, but the search for HKMT inhibitors is still in its infancy. First, chaetocin, a fungal metabolite belonging to the 3,6 epidithio-diketopiperazine (ETP) class, was previously described as a specific inhibitor of the HKMT SU(VAR)3 9. Like other ETP molecules however, it exhibits a broad cytotoxicity due to the
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38

Chen, Angela Her-Ser. "The interactions between EcoKI methyltransferase and specific DNA duplexes." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/14454.

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The S polypeptide of the <I>Eco</I>KI Type I methyltransferase (mtase) has the function of recognising DNA. Specific contacts between <I>Eco</I>Ki (mtase) and the DNA containing its recognition sequence (-AAC-(N)<SUB>6</SUB>-GTGC-) have been investigated using various substituted oligonucleotides, namely 4-thiothymidine, 5-bromodeoxyuridine, 5-iododeoxyuridine and deoxyuridine. After ultraviolet irradiation, the DNA-S polypeptide crosslinked bands were observed on the specific target recognition DNA, but not on the non-specific DNA by SDS-PAGE gel electrophoresis. The crosslinking of DNA and m
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39

Lee, Min-Hyung. "The Function of SUV39H Histone Methyltransferase in Alveolar Rhabdomyosarcoma." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1283373657.

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40

Smith, Porsha L. "Protein Arginine Methyltransferase 5 as a Driver of Lymphomagenesis." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1468975682.

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41

Howell, Nathan W. "Substrate specificity of the Trm10 m1R9 tRNA methyltransferase family." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563209805137069.

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42

Batista, Inês de Albuquerque Almeida. "Contribution of SETD7 methyltransferase to cell proliferation and differentiation." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/18505.

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Mestrado em Biomedicina Molecular<br>A SETD7 foi originalmente identificada como uma metiltransferase da histona 3, catalisando a monometilação da sua lisina 4, o que, por sua vez, provoca a abertura da cromatina e activação da transcrição genética. Recentemente, tem sido demonstrado que várias outras proteínas, tais como ER, HIF-, STAT3 e DNMT, são alvo de metilação pela SETD7. Devido à grande variedade de funções desempenhadas pelos alvos moleculares da SETD7, esta enzima é um potencial regulador de vários processos vitais para as células, isto é, do ciclo celular, resposta a danos no ADN,
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43

Thomas, Martin Geoffrey. "The role of nicotinamide N-methyltransferase in Parkinson's disease." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-nicotinamide-nmethyltransferase-in-parkinsons-disease(b4711b58-9f3d-458f-a7a1-c7f15d658a86).html.

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Parkinson’s disease (PD) is a progressive neurological movement disorder characterised by degenerating dopaminergic neurons in the midbrain’s substantia nigra pars compacta (SNpc). In the majority of cases, PD is thought to be caused by a plethora of overlapping factors that combine to cause toxicity in SNpc neurons. The enzyme nicotinamide N-methyltransferase (NNMT) is expressed at higher levels in the brain of PD patients. However, whether this association is indicative of a causative role in PD is unclear. The biochemical effects of NNMT expression were determined by comparing the NNMT-V5 e
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44

Patel, Jigar. "Site directed mutagenesis of L-pyrrolysine in dimethylamine methyltransferase." Connect to resource, 2009. http://hdl.handle.net/1811/36534.

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45

Reenilä, Ilkka. "Catechol-O-methyltransferase activity : assay, distribution and pharmacological modification." Helsinki : University of Helsinki, 1999. http://ethesis.helsinki.fi/julkaisut/laa/biola/vk/reenila/.

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46

Blissing, Annica. "Thiopurine S-methyltransferase - characterization of variants and ligand binding." Licentiate thesis, Linköpings universitet, Kemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-136558.

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Thiopurine S-methyltransferase (TPMT) belongs to the Class I S-adenosylmethionine-dependent methyltransferase (SAM-MT) super family of structurally related proteins. Common to the members of this large protein family is the catalysis of methylation reactions using S-adenosylmethionine (SAM) as a methyl group donor, although SAM-MTs act on a wide range of different substrates and carry out numerous biologically important functions. While the natural function of TPMT is unknown, this enzyme is involved in the metabolism of thiopurines, a class of pharmaceutical substances administered in treatme
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47

Cheung, Siu-ping, and 張小屏. "Genotypic and phenotypic analysis of the thiopurine S-methyltransferase (TPMT) gene with clinical correlation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193543.

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Immunosuppressants (such as azathioprine and 6‐mercaptopurine) are widely used in the management of patients having rheumatic diseases, inflammatory bowel diseases, hematological malignancies and organ transplant rejections. However, the adverse effects and effectiveness of these drugs are dependent on the metabolism by the enzyme, thiopurine S‐methyltransferase (TPMT), inside the body and the activity of this enzyme is determined by its genetic polymorphism. This study mainly focused on four known mutations, TPMT*2, TPMT*3A, TPMT*3B and TPMT*3C which were detected by three sets of primers, G2
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48

Copin, Nane. "Catecholamine synthesising enzymes in the programming of hypertension by mild protein restriction during gestation." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268370.

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49

Cotton, Naomi Johanna Helen. "Biological significance, oxidative inhibition, and glutathiolation of human soluble catechol-O-methyltransferase /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/9207.

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50

Friederich, Almut. "Untersuchungen zur DNA-Bindung der DNA-Methyltransferase aus Thermus aquaticus." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=961856564.

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