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Dissertations / Theses on the topic 'Metronomica'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

SCAGLIOTTI, ARIANNA. "Analyzing the impact of metronomic scheduling and dosing of 5-Fluorouracil and Vinorelbine in triple-negative breast cancer and endothelial cells." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/304796.

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Il tumore alla mammella triplo-negativo (TNBC) rappresenta il sottotipo di tumore alla mammella più aggressivo ed è spesso associato ad una breve sopravvivenza libera da malattia. La dose massima tollerata, utilizzata come terapia standard (STD), rimane la prima opzione terapeutica per pazienti con TNBC, anche se non è sufficiente nel bloccare le recidive, le quali rimangono la prima causa di morte per questo tipo di tumore. Recentemente, è stato testato un diverso approccio terapeutico, chiamato chemioterapia metronomica (mCHT), che prevede la continua somministrazione della minima dose biolo

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2

Murray, Alexandra M. "Novel anti-endothelial therapeutic strategies in malignant melanoma : the metronomic approach." Thesis, University of Hull, 2011. http://hydra.hull.ac.uk/resources/hull:5288.

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Treatment strategies for advanced malignancy remain limited in their success, despite major advances in the understanding of cancer aetiology and molecular biology. The incidence of many cancers, including melanoma, continues to rise, with a huge demand for therapies even if treatment goals are purely cytostatic. One particular therapeutic strategy is the metronomic (continuous and low) dosing of conventional chemotherapy. There is evidence to suggest that tumour vasculature is the main target of this dosing schedule resulting in an overall 'non specific' anti-angiogenic effect. It is now bein

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3

Bonus, Alexander Evan. "The Metronomic Performance Practice: A History of Rhythm, Metronomes, and the Mechanization of Musicality." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1270221548.

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4

Kubisch, Rebekka. "Mechanism of cancer evading metronomic chemotherapy and action of Archazolid as an anti-metastatic drug." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-158654.

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In the present study the mechanisms leading to acquired chemoresistance, as well as new treatment strategies implying the prevention evading of tumor cells were addressed. Resistance formation is one of the major hurdles in cancer therapy. Metronomic antiangiogenic treatment of xenografted prostate cancer tumors in mice with cyclophosphamide (CPA) results in the appearance of resistant tumors. To investigate the complex molecular changes occurring during resistance formation, a comprehensive gene expression analysis of the resistant tumors in vivo was performed. A multitude of differenti

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5

Mendes, Analy Ramos [UNESP]. "Avaliação da quimioterapia metronômica em carcinomas mamários de cadelas por imunomarcações." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/128087.

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Made available in DSpace on 2015-10-06T13:03:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-08-15. Added 1 bitstream(s) on 2015-10-06T13:18:49Z : No. of bitstreams: 1 000848999.pdf: 1544826 bytes, checksum: 3fb73afedffc7650ac4620d6a79c29e9 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>The canine mammary tumor (CMT) is the neoplasia that most commonly affects not spayed bitches. Therapy for CMT is a challenge since there are not described effective treatments for high-grade tumors. A therapeutic option that slows down tumor angiogenesis is metronomic c

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6

Mendes, Analy Ramos. "Avaliação da quimioterapia metronômica em carcinomas mamários de cadelas por imunomarcações /." Araçatuba, 2014. http://hdl.handle.net/11449/128087.

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Resumo:A neoplasia mamária canina (NMC) é o tipo de neoplasia que mais comumente afeta cadelas não castradas. A terapia para a NMC é um desafio já que não são descritos tratamentos efetivos para neoplasias de alto grau histológico. Uma possibilidade terapêutica que age diminuindo a angiogênese tumoral é a quimioterapia metronômica (QM). Tem sido proposta a quantificação da angiogênese tumoral através da mensuração do fator de crescimento endotelial vascular (VEGF) e da densidade microvascular (DMV). Desta forma, neste estudo, foi avaliada a resposta de carcinomas mamários caninos à QM por mens

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7

Lam, Thomas B. L. "Development of a novel anti-endothelial therapeutic strategy combining metronomic chemotherapy dosing with VRGFR-2 inhibition." Thesis, University of Hull, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421989.

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8

Sá, Ana Isabel da Silva. "Avaliação dos efeitos secundários induzidos pela administração oral de ciclofosfamida em regime de quimioterapia metronómica em cães e gatos : estudo retrospetivo de 36 casos." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2016. http://hdl.handle.net/10400.5/12006.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A quimioterapia metronómica (QM) consiste na administração de baixas doses de compostos citotóxicos, de forma contínua, sem pausa, por um longo período de tempo. O fármaco citostático mais utilizado em QM é a ciclofosfamida (CIC). Este estudo teve como objetivo avaliar os efeitos adversos induzidos pela QM com CIC, administrada por via oral, em cães e gatos, diagnosticados com neoplasias malignas, através da caracterização dos efeitos secundários manifestados. Incluiram-se todos os cães e gatos, machos e fêmeas, submetidos a tratamen

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9

Marighetti, P. "RESIDUAL DORMANT CANCER STEM CELL FOCI ARE RESPONSIBLE FOR TUMOR RELAPSE AFTER ANGIOGENIC METRONOMIC THERAPY IN HEPATOCELLULAR CARCINOMA XENOGRAFTS." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/169919.

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Hepatocellular carcinoma (HCC) is the fifth most common solid tumor and the third leading cause of cancer-related death. Current available chemotherapeutic options are not curative due in part to their resistance to conventional therapies. We have generated orthotopic HCC mouse models in immunodeficient NOD/SCID/IL2rγ null mice by injection of AFP- and/or luciferase-expressing HCC cell lines and primary cells from patients, where tumor growth and spread can be accurately monitored in a non-invasive way. Low dose metronomic administration of cyclophosphamide (LDM-CTX) causes in this model comp

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10

Nim, Rasmus. "Upplevelser av en mobiltelefonapplikations metronoma ljudstimulans under anaeroba intervaller : En experimentell studie med elitfriidrottare." Thesis, Karlstads universitet, Handelshögskolan, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-39176.

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Syfte: Syftet med denna kandidatuppsats är att förklara de positiva och negativa aspekter elit-friidrottare upplever av mobiltelefonens metronoma ljudstimulans påverkan under anaeroba intervaller, för en eventuell vidareutveckling.Metod: En applikation med grundläggande funktionalitet, som kunde användas vid testtillfället, utvecklades. 8 stycken elitfriidrottare som vid testtillfället hade topp 20 bästa resultat i sin gren, och ålder, i Sverige genomförde 6 anaeroba intervaller utifrån deras eget träningsprogram. Varannan intervall fick de hjälp av mobiltelefonapplikationen och varannan fick

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11

Kubisch, Rebekka [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Mechanism of cancer evading metronomic chemotherapy and action of Archazolid as an anti-metastatic drug / Rebekka Kubisch. Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1037311507/34.

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12

Louie, Cheryl Ann. "The effects of music and metronomic beat on heart rate, ratings of perceived exertion, and physical endurance prior to a heart rate cut-off." Scholarly Commons, 1989. https://scholarlycommons.pacific.edu/uop_etds/2174.

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This study examined the effects of music and metronomic beat on heart rate (HR). ratings of perceived exertion (RPE). and physical endurance in healthy females ages 18 to 30. Volunteers were screened via a health questionnaire and the Astrand Work Test on a Monark bicycle ergometer. yielding a predicted aerobic working capacity (V02) of 28 mililiters or more. The 30 subjects were then randomly assigned to one of two experimental conditions (music or metronome group) for a cycling test at 75% capacity. HR and Borg RPE were measured repeatedly, with a posttest measure of physical endurance (kilo

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13

Ferrer, Font Laura. "Tuning response to therapy in preclinical GL261 glioblastoma through CK2 targeting and temozolomide metronomic approaches: non-invasive assessment with MRI and MRSI-based molecular imaging strategies." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/402400.

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El treball descrit en aquesta tesi fa referència al tractaments de glioblastomes (GBM) GL261 preclínics que creixen en ratolins C57BL/6, també al seguiment no invasiu de la resposta a la teràpia, usant tècniques de ressonància magnètica (RM). El model immunocompetent GL261 GBM s’indueix per injecció estereotàctica de cèl·lules GL261 a l’estriat de ratolins WT C57BL/6. Tres agents terapèutics s’han provat en aquest model: el CX-4945®, inhibidor de la proteïna kinasa II (CK2), i dos agents alquilants d’administració oral usats habitualment en pràctica clínica pel tractament de GBM: la temozolami

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14

Stempak, Diana Christine. "Metronomic chemotherapy and celecoxib : an antiangiogenic approach for pediatric cancer." 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=371022&T=F.

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15

Davies-Shawhyde, Nick. "Metronomic photodynamic therapy as a treatment for malignant brain tumours." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=450535&T=F.

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16

Huang, Chun-Yi, and 黃鈞奕. "Metronomic Therapy with Chlorambucil and Piroxicam in Spontaneous Canine Cancers." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/83052320746170666000.

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碩士<br>國立臺灣大學<br>臨床動物醫學研究所<br>102<br>Metronomic chemotherapy, the low-dose, frequently administered chemotherapy has revealed an important impact on the stabilization of cancer disease. Metronomic chemotherapy has revealed recently as an alternative treatment protocol to slow down cancer progression by its known antiangiogenic effect and modulation of immune status without severe adverse effects. The aim of this study was to evaluate the treatment outcome, tolerability and safety of a combination low-dose chlorambucil at a dosage of 3-4 mg/m2 daily and standard-dose piroxicam at a dosage of 0.3

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17

Chang, Yung-Ching, and 張詠菁. "Metronomic Chemotherapy with Cyclophosphamide and Piroxicam in Dogs with Malignant Tumors." Thesis, 2019. http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22107NCHU5541021%22.&searchmode=basic.

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碩士<br>國立中興大學<br>獸醫學系暨研究所<br>107<br>Metronomic chemotherapy (MC) is defined as the continuous oral administration of chemotherapeutic drugs at doses that are significantly lower than conventional maximally tolerated dose with no extended drug-free intervals. The mechanisms of MC included the effect on neovascularization, stimulating anticancer immune response and the induction of tumor dormancy. The aim of this study was to evaluate the clinical outcome of dogs with various malignant tumor treated with MC of cyclophosphamide (CTX) and/or piroxicam. This study was a retrospective study. One hund

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18

Kumar, Sushil. "Preclinical Evaluation of Oral Metronomic Topotecan and Pazopanib for the Treatment of Aggressive Extracranial Pediatric Solid Tumors." Thesis, 2013. http://hdl.handle.net/1807/43627.

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Low Dose Metronomic (LDM) chemotherapy, combined with VEGF pathway inhibitors, is a highly effective strategy to coordinately inhibit angiogenesis and tumor growth. We have tested the efficacies of daily oral LDM topotecan alone and in combination with pazopanib, in three pediatric extracranial solid tumors mouse models. We also investigated the effect of prolonged combination therapy with the combination on tumor behavior in a neuroblastoma mouse xenograft model. In-vitro dose-response study of topotecan and pazopanib was conducted on several cell lines. In-vivo antitumor efficacies of drugs,

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19

Du, Manoir Jeanne Michelle. "Combination trastuzumab metronomic low-dose chemotherapy for the treatment of erbB2 overexpressing breast cancer." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=95152&T=F.

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20

Wu, Junjie. "Metronomic cylcophosphamide-activated anti-tumor immune responses: dose and schedule dependence in mouse models." Thesis, 2015. https://hdl.handle.net/2144/16318.

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Metronomic cyclophosphamide (CPA) treatment activates robust anti-tumor immunity and induces regression of implanted tumors in mouse models of brain cancer when administered on an intermittent, every 6-day schedule (CPA/6d), but not on a daily low-dose or a maximum-tolerated dose schedule. Five intermittent metronomic CPA schedules were investigated in GL261 gliomas implanted in scid mice. Metronomic CPA treatments spaced 9 or 12 days apart induced extensive tumor regression, however, tumor-infiltrating natural killer cell responses were not sustained, and tumor growth rapidly resumed after tr

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21

Su, Nai-Wen, and 蘇迺文. "Anti-Cancer Effects and Mechanisms of Cordycepin as Metronomic Therapeutic Agent and Radiosensitizer against Oral Cancer." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/5m3b46.

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博士<br>國立陽明大學<br>傳統醫藥研究所<br>107<br>ABSTRACT Study background and aim Squamous cell carcinoma of the head and neck (SCCHN) is the 6th most common cancer and causes a major cancer-related mortality. In Taiwan, sixty-to-seventy percent of SCCHN arises from oral cavity, namely oral squamous cell carcinoma (OSCC). Despite combination treatments with surgery, radiotherapy (RT) and chemotherapy, the long term survival remains approximately 50%. Patients with recurrent or refractory diseases have even dismal prognosis with a median overall survival 7 to 10 months. There are great unmet medical needs in

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22

Gaspar, Tiago Bordeira. "Low-dose metronomic chemotherapy: insight into the modern cancer field: chemotherapeutic approach of hemangiosarcoma in dogs: a preliminary retrospective study." Master's thesis, 2015. http://hdl.handle.net/10348/6206.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A era da quimioterapia, iniciada a meio do século passado, tem sido dominada pelo uso habitual de protocolos de quimioterapia de dose intensa, os quais se baseiam no conceito de dose máxima tolerada. Ao promoverem um equilíbrio entre a qualidade de vida do animal e o objetivo de destruir prontamente o maior número possível de células tumorais, estes protocolos ocupam ainda hoje um lugar de destaque na prática clínica diária. Contudo, aquando da entrada do novo milénio, a quimioterapia metronómica foi introduzida como uma possível a

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