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Journal articles on the topic 'Mexidol'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Yasnetsov, Vik V., Yu V. Ivanov, S. К. Karsanova, and V. V. Yasnetsov. "ACTION OF MELATONIN COMBINATIONS WITH 3-HYDROXYPYRIDINE DERIVATIVES ON NEURONS OF THE 1ST VESTIBULAR ZONE OF THE CEREBRAL CORTEX IN MAMMALS." Aerospace and Environmental Medicine 55, no. 3 (2021): 81–86. http://dx.doi.org/10.21687/0233-528x-2021-55-3-81-86.

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Experiments with cats showed that new 3-hydroxypyridine derivative IBKhF-27, mexidol and melatonin, and combination of IBKhF-27 with melatonin and mexidol affected directly 84.8; 67.8; 77.4; 97.9 and 88.1 % neurons of the 1st vestibular zone of the cerebral cortex, respectively. Inhibition by IBKhF-27 was observed 1.4 times more often than by mexidol. Combinations of IBKhF-27 with melatonin and mexidol produced the inhibitive effects on neurons oftener than each component separately; the direct effect of IBKhF-27 with melatonin occurred oftener than each of these two components separately. Als

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2

Mozhokina, G. N., A. G. Samoylova, and I. A. Vasilyeva. "Possibilities of Using Nootropic Drugs to Reduce Neurotoxic Reactions Caused by Anti-tuberculosis Drugs in Experimental Conditions." Tuberculosis and Lung Diseases 102, no. 3 (2024): 6–11. http://dx.doi.org/10.58838/2075-1230-2024-102-3-6-11.

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The objective: to evaluate the neuroprotective activity of cytoflavin and combinations of mexidol with vitamin B6 or Magne B6 by changes in behavioral reactions in rats during in-take of a neurotoxic combination of anti-tuberculosis drugs.Subjects and Methods. Non-linear female rats divided in 4 groups were used in this study. For 14 days, all rats received a combination of Mxf+Lzd+Cs+Pto daily. Additionally, rats of Group 2 were administered cytoflavin before administration of the basic combination; Group 3 – Mexidol + vitamin B6; Group 4 - Mexidol + Magne B6. Doses of anti-tuberculosis drugs

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3

Slyusar, T. A., Yu V. Abramenko, I. N. Slyusar, V. N. Abramova, and A. B. Antoshina. "Personal characteristics of patients with cerebral microangiopathy." S.S. Korsakov Journal of Neurology and Psychiatry 125, no. 3 (2025): 51. https://doi.org/10.17116/jnevro202512503151.

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Objective. To study the personality characteristics of patients with cerebral microangiopathy (CMA) and evaluate the effect of sequential therapy with Mexidol (500 mg injections intravenously for 14 days) and Mexidol FORTE 250 (250 mg tablets 3 times a day for 60 days) on the personal characteristics of patients with CMA. Material and methods. 130 patients aged 55—70 years (72 women and 58 men) with CMA, who received Mexidol as part of the complex treatment according to the specified scheme. The neuropsychological study included the study of personality traits using the multifactorial personal

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4

Voronina, T. A., S. A. Litvinova, N. A. Gladysheva, and A. V. Shulyndin. "The known and new ideas about the mechanism of action and the spectrum of effects of Mexidol." S.S. Korsakov Journal of Neurology and Psychiatry 125, no. 5 (2025): 22. https://doi.org/10.17116/jnevro202512505122.

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The review presents the results of studies concerning the multimodal mechanism of action of the Russian original drug Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate), which provides its neuroprotective effect and a wide range of clinical effects. The Mexidol molecule is represented by two related and functionally significant components: 2-ethyl-6-methyl-3-hydroxypyridine and succinate. The presence of 3-hydroxypyridine in the structure of Mexidol is associated with the antioxidant and membranotropic activity of the drug, the ability to reduce glutamate excitotoxicity, and modulate the w

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5

Kolyadich, M. I., and I. I. Shaposhnik. "Correction of cardiovascular disorders in diabetic patients with depressive simptoms." CardioSomatics 4, no. 2 (2013): 15–19. http://dx.doi.org/10.26442/cs44990.

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We studied the influence of mexidol and a-lipoic acid on cardiovascular and affective disorders' severity in patients with diabetes. 14-day administration of mexidol (300 mg/day) and a-lipoic acid (600 mg/day) had a positive impact on depressive guilt dinamics in association with a decrease in QTn-interval duration. Moreover, mexidol decreased patients' propencity to postural hypotension, and alfa-lipoic acid corrected myocardial diastolic function, pulmonary blood flow and circadian glycemia.

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Chichanovskaya, L. V., T. A. Slyusar, Yu V. Abramenko, T. M. Nekrasova, and I. N. Slyusar. "Pharmacological correction of cognitive status of patients with post-COVID syndrome." Medical alphabet, no. 21 (November 6, 2023): 7–12. http://dx.doi.org/10.33667/2078-5631-2023-21-7-12.

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Objective. To study influence of Mexidol® and Mexidol® FORTE 250 on cognitive status of patients with post-COVID syndrome.Material and methods. We examined 112 patients aged 24–60 years (55 men and 57 women) who were divided into tho groups. The main group consisted of 76 patients with confirmed SARS-CoV‑2 NEW coronavirus infection having symptoms that served as the basis for the diagnosis of post-COVID syndrome. The control group consisted of 36 people who were not ill with coronavirus infection. Patients underwent neurological and general somatic examination. To study cognitive functions, we

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7

Vazhnichaya, Ye M., Ye V. Mokliak, Yu A. Kurapov, and A. A. Zabozlaev. "Role of mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) in the obtaining of stabilized magnetite nanoparticles for biomedical application." Biomeditsinskaya Khimiya 61, no. 3 (2015): 384–88. http://dx.doi.org/10.18097/pbmc20156103384.

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Magnetite nanoparticles (NPs) are studied as agents for magnetic resonance imaging, hyperthermia of malignant tumors, targeted drug delivery as well as anti-anemic action. One of the main problems of such NPs is their aggregation that requires creation of methods for magnetite NPs stabilization during preparation of liquid medicinal forms on their basis. The present work is devoted to the possibility of mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) use for solubilization of magnetite NPs in hydrophilic medium. For this purpose, the condensate produced by electron-beam evaporation and

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8

Mankovska, I. M., O. O. Gonchar, and L. V. Bratus. "THE EFFECT OF MEXIDOL ON GLUTATHIONE SYSTEM IN RAT BRAIN UNDER MODELING OF PARKINSON’S DESEASE." Fiziolohichnyĭ zhurnal 68, no. 1 (2022): 13–19. http://dx.doi.org/10.15407/fz68.01.013.

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We studied the effects of mexidol (3-oxy-6-methyl-2-ethylpiridine succinate) on the antioxidant glutathione system in rat brain mitochondria in experimental Parkinson’s disease induced by rotenone administration. Wistar rats were divided into the following groups of 6 in each: I - intact rats (control); II - rotenone (3 mg/kg per day) was injected subcutaneously for 2 weeks; III - after rotenone intoxication, mexidol (50 mg/kg per day) was injected intraperitoneally for 2 weeks. In the suspension of brain mitochondria, the activity of NADH dehydrogenase (complex I of the mitochondrial respirat

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9

Kvachakhiya, Lekso L., Vladimir K. Shormanov, and Elena V. Maksina. "Determination of Mexidol in tablets by the method of derivative spectrophotometry." Человек и его здоровье 26, no. 2 (2023): 80–85. http://dx.doi.org/10.21626/vestnik/2023-2/10.

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Mexidol (3-hydroxy-6-methyl-2-ethylpyridine succinate) is a drug that exhibits neuroprotective, antihypoxic, anti-ischemic, nootropic, anti-stress and geroprotective effects and can suppress or slow down oxidation reactions. Оbjective: to develop a selective and simple method for assessing the content of mexidol in tablets. Materials and methods. The objects of the study were mexidol (3-hydroxy-6-methyl-2-ethylpyridine succinate) and Mexidol tablets 0.125 g. Derivative spectrophotometry was used as an analysis method. Results. The ability of mexidol to intensively absorb electromagnetic radiat

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10

Voronina, T. A. "Antioxidants/antihypoxants: the missing puzzle piece in effective pathogenetic therapy for COVID-19." Infekcionnye bolezni 18, no. 2 (2020): 97–102. http://dx.doi.org/10.20953/1729-9225-2020-2-97-102.

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This review focuses on the specific characteristics of COVID-19 disease, which leads not only to respiratory impairments (bronchoalveolar epithelium does not retain oxygen, etc.), but also decreases the level of hemoglobin and its ability to transfer oxygen to the organs and tissues and increases the level of heme, resulting in anoxemia, hypoxia in all organs and tissues, and oxidative stress. Mexidol, a drug developed in Russia, is widely used in clinical practice, including the treatment of diseases accompanied by ischemia and hypoxia. Mexidol has antihypoxic and antioxidant effects, can tre

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Фудин, N. Fudin, Хадарцев, Aleksandr Khadartsev, Несмеянов, and A. Nesmeyanov. "The mexidol effects for activation of mitochondrial activity in athletes." Journal of New Medical Technologies. eJournal 9, no. 2 (2015): 0. http://dx.doi.org/10.12737/11204.

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This brief report presents a description of the basic properties of mitochondria, providing a formation of energy in the human body, the ability to control a formation of energy under the influence of the Mexidol. The authors showed the main physiological effects of Mexidol in athletes and in various pathologies. A comparative study of growth performance of the pressing the barbell in the posture of lying and deadlifts in the main group of 15 people and control of 23 athletes was carried out. The athletes of the main group received the Mexidol in the dose of 200 mg/kg of body weight for 2,5 we

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12

Smirnova, Kseniya, and Dmitriy Gildikov. "Comparative efficacy of antioxidant drugs in an in vitro experiment." Russian veterinary journal 2021, no. 2 (2021): 37–40. http://dx.doi.org/10.32416/2500-4379-2021-2-37-40.

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The aim of this work was to study the antioxidant activity of 3-hydroxypyridine derivatives: Mexidol-Vet® and Emycidin in a model oxidation system. Using the chemiluminescence method, it was found that the introduction of Mexidol-Vet® into the test system at a dose of 1 mg reliably suppresses the amplitude of a fast flash and decreases the formation of photons (light sum value), compared with the test system / placebo and the test system / Emicidin. The antioxidant activity of Mexidol-Vet® is significantly higher than Emicidin by 28.1%.

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13

Knni, K. S., T. V. Dyomin, and L. B. Adeeva. "Effect of mexidol on the efficiency of intravenous thrombolytic therapy for ischemic stroke during the therapeutic window." Neurology, Neuropsychiatry, Psychosomatics 10, no. 3 (2018): 86–90. http://dx.doi.org/10.14412/2074-2711-2018-3-86-90.

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Objective: to evaluate the effect of intravenous mexidol on the efficiency of intravenous thrombolytic therapy (TLT) during the therapeutic window. Patients and methods. The retrospective study enrolled 123 patients with ischemic stroke (IS) who had undergone intravenous TLT in the vascular centers of the Republic of Tatarstan. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the time course of changes in their neurological status. According to the baseline severity of a neurological deficit, all the patients were divided into three subgroups: 1) mild IS (<8 NIHSS s

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14

Косолапов, V. Kosolapov, Трегубова, et al. "Influence of Antioxidant Compounds on Spatial Orientation and Memory in Rats in Morris Water Maze Test." Journal of New Medical Technologies 22, no. 4 (2015): 34–38. http://dx.doi.org/10.12737/17022.

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The data of studies of the new antioxidant agent Enoxifol (2‐(3,4‐dioxyphenyl)‐9‐ diethylaminoethylimidazo[1.2‐a] benzimidazole dihydrobromide) (10 mg/kg) action on spatial orientation and memory in rats using Morris test in comparison to Mexidol (2‐ethyl‐6‐methyl‐3‐oxypyridine succinate) (100 mg/kg) are presented. Morris water maze test is widely used to evaluate spatial orientation and memory in experimental animals. Mexidol was taken as the native etalon antioxidant drug having the wide spectrum of psychotropic activities. It was shown that Enoxifol significantly 3 f

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15

Ushkalova, E. A., S. K. Zyryanov, and O. I. Butranova. "Safety of Mexidol® (ethylmethylhydroxypyridine succinate) in adult patients of different age groups." Neurology, Neuropsychiatry, Psychosomatics 14, no. 5 (2022): 77–82. http://dx.doi.org/10.14412/2074-2711-2022-5-77-82.

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To reduce the risk of developing adverse events (AEs) and increase the adherence of elderly patients to treatment, it is recommended to limit maximally the total number of prescribed drugs (DR), using one drug for the treatment of two or more pathologies if possible. The drugs that meet the criteria for use in elderly patients and / or patients with comorbidity include the original Russian drug Mexidol® (ethylmethylhydroxypyridine succinate), which has a multimodal mechanism of action and has multiple pharmacological effects. In order to study the safety of Mexidol in comparison with placebo i

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16

Gribacheva, I. A., T. F. Popova, E. V. Petrova, and A. V. Zvonkova. "Possibilities of multimodal neuroprotection in patients with chronic cerebral ischemia on the background of arterial hypertension and atherosclerosis." Neurology, Neuropsychiatry, Psychosomatics 15, no. 2 (2023): 19–26. http://dx.doi.org/10.14412/2074-2711-2023-2-19-26.

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hronic cerebrovascular pathology is manifested by a combination of cognitive, emotional and autonomic disorders. Correct and timely assessment and accurate diagnosis of emotional and autonomic disorders and their timely correction are important, among other things, for slowing down the progression of cognitive deficits. Objective: to study the efficacy and safety of Mexidol administered intravenously by drip infusion (500 mg 1 time per day) for 14 days, followed by oral administration of the drug Mexidol FORTE 250 at a dose of 250 mg 3 times a day for 60 days in middle-aged patients with chron

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17

Ziyatdinova, G. K., and G. K. Budnikov. "Voltammetric Determination of Mexidol." Pharmaceutical Chemistry Journal 39, no. 8 (2005): 447–48. http://dx.doi.org/10.1007/s11094-005-0179-8.

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18

Shavarova, E. K., E. R. Cazakhmedov, M. V. Alekseeva, L. G. Ezhova, and Zh D. Kobalava. "Role of antioxidant therapy in patients with moderate and severe COVID-19." Infekcionnye bolezni 19, no. 1 (2021): 159–64. http://dx.doi.org/10.20953/1729-9225-2021-1-159-164.

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The coronavirus disease COVID-19 is characterized by high mortality and the lack of effective etiotropic therapy. Activation of oxidative stress may be one of the links in the pathogenesis of organ damage of this infection. Objective. To assess the ability of Mexidol® to influence the rate of clinical improvement in pneumonia caused by the SARSCoV-2 virus in hospitalized patients with the novel coronavirus disease COVID-19 and concomitant discirculatory encephalopathy. 62 patients over the age of 18 years with confirmed new coronavirus disease COVID-19 according to computed tomography (CT) of

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Тихомирова, Л. Н., Д. Д. Мациевский, С. В. Ревенко, Н. Ф. Сафина, and И. А. Тараканов. "Correction of pathological periodic respiration with Mexidol in rats." Nauchno-prakticheskii zhurnal «Patogenez», no. 3() (September 29, 2018): 121–23. http://dx.doi.org/10.25557/2310-0435.2018.03.121-123.

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В острых опытах на наркотизированных самцах беспородных белых крыс изучали возможность применения метаболической терапии мексидолом для коррекции периодического патологического дыхания, вызванного оксибутиратом. В интервале доз 40-200 мг/кг мексидол нормализовал дыхание, причем продолжительность нормализации зависела от его концентрации. При использовании мексидола в дозах 100-200 мг/кг длительность сохранения нормального ритмического дыхания составляла несколько часов. Проведенное исследование показало, что мексидол является эффективным средством коррекции периодического патологического дыхан

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Трегубова and I. Tregubova. "Mnemotropic and anxiolytic activity of mexidol and enoxifol." Journal of New Medical Technologies. eJournal 9, no. 4 (2015): 0. http://dx.doi.org/10.12737/14918.

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The article presents the research findings of influence of antioxidant compounds Enoxifol (10 mg/kg) and Mexidol (100 mg/kg) on behavior, emotional sphere and ability for self-regulation of experimental animals. The mechanism of Enoxifol and Mexidol action at high nervous functions was established on the basis of tests allowing to connect behavior reactions with the main neuromediator systems. In the “open field” test the emotional labality, stress resistance and research activity were evaluated in control rats and rats treated for three days by antioxidants. The

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Siprov, Alexander, Mariya Solovyova, Pavel Skopin, et al. "CORRECTION OF THROMBOCYTOPOIESIS IN RATS WITH WALKER-256 CARCINOMA USING AN ANTIOXIDANT SUPPLEMENT IN THE SETTING OF CYTOSTATICS." Archiv Euromedica 11, no. 3 (2021): 14–16. http://dx.doi.org/10.35630/2199-885x/2021/11/3/3.

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— In this study, we’ve evaluated the myelotoxic effect of treating Walker-256 carcinoma with cytostatics, followed by correction of thrombocytopenia with liposomal and liposome-free mexidol. The study included 60 rats, which, depending on the type of treatment, were divided into 5 groups. We recorded the greatest increase in the number of platelets on the background of liposomal mexidol both on the 3rd and 7th day after the start of chemotherapy. At the end of the monitoring, the myeloprotective effect was 30% higher in the liposomal mexidol compared to its non-liposomal form. Conclusion: Acti

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Yasnetsov, Vik V., D. E. Kaurova, E. Yu Bersenev, and S. Ya Skachilova. "INVESTIGATION OF THE ANTIHYPOXIC PROPERTIES OF NEW NICOTINIC ACID DERIVATIVES." Aerospace and Environmental Medicine 54, no. 5 (2020): 73–76. http://dx.doi.org/10.21687/0233-528x-2020-54-5-73-76.

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Two of the five new nicotinic acid derivatives proved to have the antihypoxic properties in tests with mice exposed to acute normobaric hypoxic hypoxia with hypercapnia. Specifically, LKhT 4–19 (100 mg/kg) extended lifetime of the animals by 11 %; LKhT 6-19 doses of 50 and 100 mg/kg extended lifetime by 23 and 34 %, respectively. The antihypoxic effect of LKhT 6–19 (50 mg/kg) outperformed in 1.2 times mexidol (substance of comparison) at the similar dose and was highly competitive at the dose of 100 mg/kg. For reference, mexidol is a 3-hydroxypyridine derivative (ethylmethylhydroxypyridine suc

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SEDOVA, L. A., YU N. PERLAMUTROV, A. V. TERESHCHENKO, and K. B. OLKHOVSKAYA. "Optimizing the therapy of the erosive and ulcerative form of lichen acuminatus in the mucous coat of the oral cavity." Vestnik dermatologii i venerologii 88, no. 6 (2012): 56–59. http://dx.doi.org/10.25208/vdv755.

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Objective. To assess the clinical efficacy of an antioxidant therapy with Mexidol for the treatment of patients suffering from lichen acuminatus in the mucous coat of the oral cavity. Materials and methods. The study involved 62 patients suffering from the erosive and ulcerative form of lichen acuminatus in the mucous coat of the oral cavity. The severity of dermatosis was assessed based on the determination of the affected area of the mucous coat of the oral cavity. The activity of antioxidant protection was assessed based on the determination of the level of lipid peroxidation products, tota

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Volchegorskii, Ilya A., Andrey V. Vazhenin, and Anna P. Alekseeva. "The effect of antioxidant drugs on the self-assessment of clinical symptoms in women during radiation therapy after surgical treatment of endometrial cancer: Placebo-controlled randomized trial." Journal of Modern Oncology 24, no. 2 (2022): 177–83. http://dx.doi.org/10.26442/18151434.2022.2.201556.

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Aim. Comparative analysis of the effect of methylethylpiridinol (Emoxipine), ethylmethylhydroxypyridine malate (Ethoxidol) and ethylmethylhydroxypyridine succinate (Mexidol) on the self-assessment of nonspecific clinical symptoms in women receiving adjuvant radiation therapy after radical surgical treatment of uterine body cancer. Materials and methods. A short-term, prospective, simple blind, placebo-controlled, randomized study of the effect of 14-day course use of emoxipine (150 mg [0.87 mmol] per day intravenously), ethoxidol (225 mg [0.83 mmol] per day intravenously) and mexidol (22

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Butyugin, Ivan, Natalia Merkulova, and Natalia Kornilova. "CLINICAL AND LABORATORY RATIONALE FOR LOCAL USE OF ANTIOXIDANTS IN THE TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS." Actual problems in dentistry 20, no. 3 (2024): 55–60. https://doi.org/10.18481/2077-7566-2024-20-3-55-60.

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Introduction. In periodontitis, there is a disruption of the balance between the rate of formation of active forms of oxygen and their inactivation in the tissue. This fact dictates the need to use antioxidants to treat periodontal diseases. Objective: clinical and laboratory justification for the local use of antioxidant drugs in the treatment of chronic generalized periodontitis. Materials and methods. A study was conducted of the clinical and laboratory effectiveness of local application of 5% tocopherol acetate solution, 5% Mexidol solution and Kudesan Forte solution in 99 patients with CG

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Yugatova, Natal'ya. "Effectiveness of Mexidol-Vet® on the background of ultraviolet irradiation." Russian veterinary journal 2021, no. 1 (2021): 25–28. http://dx.doi.org/10.32416/2500-4379-2021-1-25-28.

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The article describes the effectiveness of the drug Mexidol-Vet® against the background of simulated irradiation of rats with the bactericidal irradiator «GENERIS». The clinical picture of the condition of animals exposed to radiation is shown. The article presents the results of blood tests under ultraviolet radiation, as well as the dynamics of the hematological status of animals when using the drug Mexidol-Vet®.

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Gildikov, Dmitriy. "Hepatoprotective and antioxidant effects of Mexidol-Vet® in an experiment on rats." Russian veterinary journal 2020, no. 5 (2020): 38–42. http://dx.doi.org/10.32416/2500-4379-2020-5-38-42.

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The aim of the work was to establish the hepatoprotective and antioxidant effect of Mexidol-Vet® in rats with toxic hepatitis. We have reproduced the toxic hepatitis in sexually mature male rats (n = 90) by a single intragastric injection of carbon tetrachloride. For 30 days, we studied reactivity, variations in blood biochemical parameters, the intensity of iron-induced chemiluminescence of homogenates and histological changes in the liver. The experiment confirmed the antioxidant effect and for the first time established the hepatoprotective effect of Mexidol-Vet®. The use of Mexidol-Vet® in

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Martemianova, E. G. "CLINICAL ASPECTS OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE IN ELDERLY PATIENTS WITH CARDIOVASCULAR PATHOLOGY." Cardiovascular Therapy and Prevention 17, no. 2 (2018): 57–62. http://dx.doi.org/10.15829/1728-8800-2018-2-57-62.

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Aim. To evaluate efficacy and safety of original ethylmethylhydroxypyridine succinate (Mexidol) in cardiological patients ≥75 year old.Material and methods. In the observational study, according to ethical standards of Khelsinki Declaration, with informed consent, 24 patients participated, age 7588 y. o. Inclusion criteria: age ≥75 y. o.; already diagnosed coronary heart disease (CHD) and/or chronic heart failure (CHF); Mexidol usage. Exclusion criteria: absent informed consent, severe comorbidities. Mean age of the patients at inclusion 80,33±4,06 y. o.; 16 (66,7%) females and 8 (33,3%) male

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Кузнецова, Эмма, Emma Kuznetsova, Виктория Горохова, et al. "INTERACTION OF ERYTHROCYTE MEMBRANES WITH DERIVATIVES OF 3-OXYPIRIDINES." Acta biomedica scientifica 2, no. 5 (2018): 60–64. http://dx.doi.org/10.12737/article_5a3a0dbe2be5a0.22172442.

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In connection with the increased interest in the use of auto-erythrocytes for directional drug transport, the study of the ability of erythrocytes to sorb an antioxidant drug is becoming topical. The article considers the method of spectro- photometry developed for evaluating the ability of erythrocytes to load with a mexidol preparation under conditions of natural sorption and a method created for determining the drug concentration in erythrocyte biological medias. Materials and methods. The peripheral blood of 15 clinically healthy males aged 20 to 45 years was used a

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Shchulkin, A. V., I. V. Chernykh, Yu V. Abalenikhina, et al. "The effect of Mexidol on the level of neurogenesis markers in acute cerebrovascular accident in the experiment." S.S. Korsakov Journal of Neurology and Psychiatry 125, no. 2 (2025): 107. https://doi.org/10.17116/jnevro2025125021107.

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Objective. To study the effect of Mexidol on the level of factors regulating neuroregenesis. Material and methods. The study was performed on male Wistar rats. Focal cerebral ischemia was reproduced by endovascular occlusion-reperfusion of the right medial cerebral artery. The duration of occlusion was 60 min. During the beginning of reperfusion, the animals were given a single intravenous injection of saline solution or the drug Mexidol at a dose of 50 mg/kg. 4, 8 and 24 hours after the beginning of reperfusion in the ischemic hemisphere, the relative amount of molecules regulating neurogenes

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Konovalova, Elena A., and Elena S. Chernomortseva. "The study of the endothelial protective properties of the L-norvaline combination with mexidol in the simulation of L-NAME-induced NO deficiency." Research Results in Pharmacology 5, no. 4 (2019): 41–46. http://dx.doi.org/10.3897/rrpharmacology.5.38405.

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Introduction: The endothelium is considered as a target for the prevention and treatment of pathological processes leading to cardiovascular diseases. Materials and methods: Endothelial dysfunction was simulated in male rats using an e-NOS inhibitor L-NAME (25 mg/kg/day intraperitoneally, 7 days). This pathology was then corrected by administering mexidol at a dose of 60 mg/kg and L-norvaline at a dose of 10 mg/kg, as well as the combination of both at the same doses, intragastrically, through an atraumatic probe, once a day. Results and discussion: A combination of L-norvaline at a dose of 10

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Konovalova, Elena A., and Elena S. Chernomortseva. "The study of the endothelial protective properties of the L-norvaline combination with mexidol in the simulation of L-NAME-induced NO deficiency." Research Results in Pharmacology 5, no. (4) (2019): 41–46. https://doi.org/10.3897/rrpharmacology.5.38405.

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Introduction: The endothelium is considered as a target for the prevention and treatment of pathological processes leading to cardiovascular diseases. Materials and methods: Endothelial dysfunction was simulated in male rats using an e-NOS inhibitor L-NAME (25 mg/kg/day intraperitoneally, 7 days). This pathology was then corrected by administering mexidol at a dose of 60 mg/kg and L-norvaline at a dose of 10 mg/kg, as well as the combination of both at the same doses, intragastrically, through an atraumatic probe, once a day. Results and discussion: A combination of L-norvaline at a dose of 10

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Kuanova, Larissa. "Anxiety disorders in clinical practice - a modern view on the problem of therapy." Journal "Medicine" 5-6, no. 215-216 (2021): 63–70. http://dx.doi.org/10.31082/1728-452x-2020-215-216-5-6-63-70.

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Clinically significant anxiety occurs in 5-7% of the general population and in 25% or more of patients seen by general practitioners. The lifetime incidence of anxiety disorders can be over 30%. Anxiety in adolescence and young adulthood often later develops into depression. The line between a “normal” response to a threat and a pathological anxiety disorder is often very blurred and there may be a continuum from personal distress to mental disorder. The real clinical situation is that most people with anxiety do not have their diagnosis. Only about a quarter (27.6%) of people who meet DSM-V,

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Repina, Е. F., D. O. Karimov, G. V. Timasheva, et al. "EXPERIMENTAL EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF OXYMETHYLURACIL IN COMBINATION WITH KNOWN MEDICINES (MEXIDOL, TONAROL, ACETYLCYSTEINE)." Toxicological Review, no. 6 (January 5, 2021): 14–20. http://dx.doi.org/10.36946/0869-7922-2020-6-14-20.

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The article presents the results of morphological changes in the liver of rats after acute liver injury induced by carbon tetrachloride and prophylactic correction of injuries by combinations of oxymethyluracil with different types of medical products: «Mexidol», «Tonarol» and Acetylcysteine. The best corrective effect was established after applying a combination of oxymethyluracil with «Tonarol». Thus, according to the results obtained, the studied drugs combinations can be arranged in the following sequence in accordance with decreasing of hepatoprotective activity: OMU / «Tonarol» > OMU

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Vasil'ev, Roman. "Effect of Mexidol-Vet® on the course and outcome of acute radiation injury in rats." Russian veterinary journal 2020, no. 5 (2020): 31–37. http://dx.doi.org/10.32416/2500-4379-2020-5-31-37.

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This paper presents experimental data on the effect of the drug Mexidol-Vet® on the course and outcome of acute radiation damage in rats caused by a single, general, external gamma radiation. There was a 20 % decrease in mortality in animals relative to the control values, activation of erythropoiesis, and a decrease in the severity of erythrocytopenia, leukocytopenia, and thrombocytopenia with the use of Mexidol-Vet®. The supposed mechanism of radioprotective and therapeutic action is the pronounced antioxidant and membrane-protective properties of the drug.

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Chukanova, E. I., A. S. Chukanova, and D. D. Andrianov. "Arterial hypertension is an oxidative stress, as a pathogenetic target for the treatment of chronic cerebrovascular insufficiency." S.S. Korsakov Journal of Neurology and Psychiatry 125, no. 1 (2025): 84. https://doi.org/10.17116/jnevro202512501184.

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The increase in the development of arterial hypertension (AH), as the main modifiable risk factor for the development of acute and chronic cerebral circulatory insufficiency, often leading to a progressive decrease in cognitive status and physical activity, requires early detection and effective pathogenetic therapy. The breadth of therapeutic effects of the drug Mexidol (ethylmethylhydroxypyridine succinate) due to the multifactorial nature of its pathogenetic effects contributes to its widespread use. The safe profile of Mexidol use and the absence of drug interaction makes it relevant in th

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Kuznetsova, O. S., K. B. Lebedeva-Gueorguievskaya, A. S. Shtemberg, А. А. Perevezentsev, and Vik V. Yasnetsov. "INVESTIGATION OF MEXIDOL AS A PROMISING DRUG FOR PHARMACOLOGICAL CORRECTION OF THE CONSEQUENCES OF PROTON IRRADIATION." Aerospace and Environmental Medicine 59, no. 3 (2025): 77–83. https://doi.org/10.21687/0233-528x-2025-59-3-77-83.

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Experimental irradiation of rat’s head with protons (2 Gy) showed that mexidol injected at a dose of 150 mg/kg/d during 7 days of exposure and one day after improved considerably cognitive functions in the conditioned response tests (Active avoidance and Open field). Increase of the dose up to 250 mg\kg\d does not retain the effect. We may hypothesize that mexidol at a dose of 150 mg/kg/d compensates significantly the proton-induced changes, whereas a larger dose leads to hypercompensation with some negative manifestations.

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Moskalenko, S. V., I. I. Shakhmatov, Yu A. Bondarchuk, O. V. Alekseeva, and O. M. Ulitina. "Reaction of hemostasis system in hypercapnic hypoxia after the course of mexidol assessed by the method of thromboelastography." Kazan medical journal 99, no. 6 (2018): 936–41. http://dx.doi.org/10.17816/kmj2018-936.

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Aim. To study the reaction of hemostasis system to a single effect of hypercapnic hypoxia of maximum intensity in rats and possibility of correcting hemostasis disorders by means of a preliminary course of an antihypoxant - mexidol. Methods. The study involved sexually mature male rats (48 specimens) of the Wistar line with an average mass of 274.0 ± 32.0 g. The rats were kept on a standard diet, food and water were fed once a day between 10 and 11 hours. In the evening, animals underwent a single hypercapnic hypoxia in a special flow chamber. The state of hypercapnic hypoxia of maximum intens

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Torshin, I. Yu, O. A. Gromova, I. S. Sardaryan, and L. E. Fedotova. "A comparative chemoreactome analysis of mexidol." Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 117, no. 1. Vyp. 2 (2017): 75. http://dx.doi.org/10.17116/jnevro20171171275-84.

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Gromova, O. A., I. Yu Torshin, L. V. Stakhovskaya, E. G. Pepelyaev, V. A. Semenov, and A. G. Nazarenko. "Experience with mexidol in neurological practice." Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 118, no. 10 (2018): 97. http://dx.doi.org/10.17116/jnevro201811810197.

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Zemskova, Veronika A. "CLINICAL EFFICACY OF INCLUSION OF THE METABOLITE MESXIDOL IN THE REGIMEN OF TREATMENT OF INFLAMMATORY DISEASES COMPLICATED BY THE DEVELOPMENT OF PURULENT PROCESSES." Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ) 24, no. 2 (2023): 46–52. http://dx.doi.org/10.18499/1990-472x-2023-24-2-46-52.

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The clinical effectiveness of two therapy regimens of patients with one of the diseases pyoderma, adnexitis or soft tissue infection complicated by purulent processes was assessed. The first scheme provided for the use of basic therapy according to clinical recommendations, the second was supplemented by the metabolist Mexidol. The results of analysis of pharmacotherapy of 162 patients divided into groups according to the nosological affiliation of diseases and subhorupa according to the therapy regimen were used. It has been found that the additional prescription of Mexidol metabo

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Skachilova, Sophiya Ya., Vera Ragulina, Darya Kostina та Youri Burda. "TEST SYSTEM FOR EVALUATION OF THE INFLUENCE OF THE BIOLOGICAL ACTIVITY OF SUBSTANCES ON THE SIGNAL SYSTEM OF NF-κB: FOCUS ON THE DERIVATIVES OF 3-HYDROXYPYRIDINE". Research Results in Pharmacology 3, № (2) (2017): 50–56. https://doi.org/10.18413/2313-8971-2017-3-2-50-56.

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Introduction: The nuclear factor kappa B is one of the most promising targets for the development of innovative medicines in the development of modern pharmacology and the formation of the concept of targeted therapy. Potential candidates modulating the activity of this transcription factor are 3-hydroxypyridine derivatives. Materials and methods: At the first stage of our study, 11 pharmacological agents-inhibitors of NF-κB in vitro were screened with an estimate of the activity of the p65 subunit in mononuclear cells stimulated by bacterial lipopolysaccharide. The most active substances were

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Makletsova, M. G., G. T. Rikhireva, V. V. Poleshuk, K. V. Grjakalov, S. L. Timerbaeva, and T. N. Fedorova. "The effect of antioxidants on in vivo and in vitro methemoglobin formation in erytrocytes of patients with Parkinson`s disease." Biomeditsinskaya Khimiya 62, no. 2 (2016): 193–97. http://dx.doi.org/10.18097/pbmc20166202193.

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Methemoglobin formation was examined in erytrocytes of 16 patients with Parkinson`s disease (PD) (stage 3-4 by the Hoehn and Yahr scale). The patients receiving levodopa-containing drugs (madopar, nakom) were also treated with intramuscular injections of mexidol (daily dose 100 mg/day) for 14 days. Control group included 12 clinically healthy persons. The erythrocyte methemoglobin content was determined by electronic paramagnetic resonance (EPR) using the EPR signal intensity with g-factor 6.0. The methemoglobin content was significantly higher in erythrocytes of PD patients than in healthy do

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Timasheva, Gulnara V., D. O. Karimov, E. F. Repina, et al. "Metabolic changes on the background of acute exposure to paracetamol and evaluation of the effectiveness of hepatoprotective drug." Hygiene and sanitation 99, no. 9 (2020): 1016–21. http://dx.doi.org/10.47470/0016-9900-2020-99-9-1016-1021.

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Introduction. In modern conditions, caused by the pandemic of a new type of viral infection Covid 19, the use of paracetamol, which has hepatotoxic properties in overdose, has increased. It seems relevant to study metabolic disorders in the liver in acute paracetamol intoxication and evaluate the effectiveness of the timely use of hepatoprotective drugs. The purpose of this study is an experimental assessment of metabolic changes at the early stages of paracetamol exposure and pharmacological correction of toxic liver lesions with oxymethyluracil in comparison with known hepatoprotectors - ade

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Mammadgasanov, Telman S., Veli Y. Asmatov, and Musa M. Ganiev. "MEXIDOL AND PIRACETAM AS A CORRECTOR OF SIDE HORMONAL EFFECTS IN THE CONDITIONS OF CHRONIC ALCOHOLIZATION IN MALE RATS." Azerbaijan Pharmaceutical and Pharmacoterapy Journal 23, no. 1 (2023): 52–56. http://dx.doi.org/10.58495/cogy1986.

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The article is devoted to the study of the corrective effect of mexidol and piracetam on the level of reproduc- tive hormones in the blood, against the background of chronic alcoholism in male rats. The experiments were carried out on 40 mature male rats. Animals received intraperitoneally 25% ethanol solution at a dose of 12 ml/kg and intraperitoneally mexidol and piracetam at a dose of 200 mg/kg. The control groups were injected with saline at the rate of 0.2 ml per 100 g of body weight. After the end of the experiment, the levels of luteiniz- ing hormone (LH), estradiol (E2), follicle-stimu

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Baeva, Elena S., Elena S. Artyukhov, and Olga S. Kurkina. "Structural and functional features of donor blood hemoglobin in the presence of doxycycline and mexidol." Journal of Volgograd State Medical University 20, no. 4 (2024): 122–26. http://dx.doi.org/10.19163/1994-9480-2023-20-4-122-126.

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The effect of mexidol, doxycycline hydrochloride and sodium nitrite solutions on human oxyhemoglobin molecules was studied by spectrophotometry. It is shown that the presence of modifiers in the incubation medium in combination and separately contributes to their specific affinity to the hemoglobin molecule, which is reflected in the change in the ratio of ligand forms of hemoprotein. A tendency to decrease the level of methemoglobin formation in samples containing doxycycline and mexidol was revealed. Preliminary incubation of hemoglobin solutions with antibiotics studied helps to reduce the

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Abramenko, Yu V. "Results of the sequential use of Mexidol and Mexidol Forte 250 in patients with chronic cerebral ischemia." Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 120, no. 3 (2020): 59. http://dx.doi.org/10.17116/jnevro202012003259.

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Shchepankevich, L. A., Yu A. Nikolaev, E. V. Taneeva, M. A. Pervuninskaya, and M. S. Shchepankevich. "The efficacy and safety study of Mexidol and Mexidol FORTE 250 in patients with chronic cerebral ischemia." Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 121, no. 10 (2021): 32. http://dx.doi.org/10.17116/jnevro202112110132.

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Ivanova, E. A., A. G. Vasilchuk, A. I. Matyushkin, and T. A. Voronina. "Effect of the combination of mexidol and diclofenac sodium on exudative inflammation in rats after ten-day preventive oral administration." Pharmacokinetics and Pharmacodynamics, no. 1 (May 1, 2022): 14–19. http://dx.doi.org/10.37489/2587-7836-2022-1-14-19.

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In rats with carrageenan-induced paw edema, diclofenac sodium significantly reduces exudation after ten-day preventive oral administration at a dose of 10 mg/kg but not 5 mg/kg. Mexidol at a dose of 100 mg/kg in combination with diclofenac sodium at a dose of 5 mg/kg (preventively orally, during 10 days, once a day) reduces paw edema during the first two out of four hours of its recording compared with the control group. However, ten-day preventive oral administration of mexidol at a dose of 100 mg/kg (once a day) increases the severity of carrageenan-induced paw edema in rats at four hours af

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Balykova, L. A., and M. I. Almyasheva. "Efficiency of dimephosphonum, cytochrom cand mexidol in the treatment of cardiac rhythm disorders in children." Kazan medical journal 82, no. 1 (2021): 5–7. http://dx.doi.org/10.17816/kazmj62976.

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The efficiency of dimephosphonum, cytochrom c and mexidol in the treatment of ventricular, supraventricular arrhythmias in children is shown. Dimephosphonum (100 mg/kg i.v.), mexidol (10 mg/kg p.o.) and cytochrom c (0,5 mg/kg i.v.) were studied in comparison with cordaron, finoptin and also with the standard neurometabolic therapy. It is shown that dimephosphonum was the most effective drug in all kinds of disturbances of cardiac rhythm and conductivity in children. In supraventricular arrithmias and sinus node dysfunction it surpasses traditional drugs. At ventricular arrhythmias dimephosphon

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