Journal articles: 'MFM'

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Zaveri, Mehul, and Neha Kawathekar. "SYNTHESIS AND ANTIMALARIAL ACTIVITY OF SOME NEW 3-PHENYL-2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES." International Journal of Current Pharmaceutical Research 9, no. 3 (May 5, 2017): 58. http://dx.doi.org/10.22159/ijcpr.2017.v9i3.18897.

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Objective: Current therapies to treat P. falciparum malaria are heavily reliant on artemisinin-based combinations. However, resistance to artemisinin has recently been identified, and resistance to key artemisinin partner drugs is already widespread. Therefore, there is an urgent need for new antimalarial drugs with improved attributes over older therapies. The objective of this research work is to synthesize new antimalarial agents more effective against clinically relevant malarial strains.Methods: In present work, a series of ten 3-phenyl-2-thioxothiazolidin-4-one (MF1-MF10) derivatives, were synthesized by Knoevenagel condensation of N-phenyl rhodanine (I1) with substituted aromatic or hetro aromatic aldehydes using microwave irradiation. N-phenyl rhodanine (I1) was synthesized by a conventional reaction involving methyl-2-mercaptoacetate (1) and phenyl Isothiocyanates in presence of triethylamine. All the synthesized compounds were characterized by various spectroscopic techniques and evaluated for in-vitro antimalarial activity by microdilution technique against resistance strains of Plasmodium falciparum.Results: The antimalarial activity data showed that six compounds (MF1, MF3, MF4, MF5, MF7 and MF8) exhibited IC50 values ranging from 1.0-1.30 µg/ml, three compounds (MF2, MF6 and MF10) displayed IC50 values in the range of 0.9-1.0 µg/ml. Compound MF9 showed most significant result with maximum activity (IC50 = 0.85µg/ml).Conclusion: The antimalarial activity results revealed that compound MF9 possess potent activity and could be identified as a promising lead for further investigation.

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SOUSA, Elane Sampaio de, Roberto Cesar De Mendonça BARBOSA, and Isaac Daniel RUDNITZKI. "Microfácies de carbonatos pensilvanianos da Formação Itaituba (Grupo Tapajós) no norte da Bacia do Amazonas, Urucará (AM)." Pesquisas em Geociências 48, no. 1 (April 16, 2021): e092531. http://dx.doi.org/10.22456/1807-9806.92531.

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A aplicação de técnicas microfaciológicas em exposições de carbonatos da Formação Itaituba (Grupo Tapajós), situados na borda norte da Bacia do Amazonas, permitiu contribuir na reconstituição paleogeográfica do Pensilvaniano da bacia, uma vez que as principais interpretações da unidade são baseadas em dados da borda sul devido a facilidade logística de acesso em condições amazônicas. A análise microfaciológica em 80 seções delgadas de uma sucessão carbonática de aproximadamente 30 m permitiu a individualização de 10 microfácies (MF): Mudstone recristalizado (MF1), Mudstone/wackestone com intraclastos (MF2), Mudstone/ wackestone com terrígenos (MF3), Dolomudstone/wackestone (MF4), Dolowackestone/ packstone com peloides (MF5), Wackestone/packstone bioclástico com foraminíferos (MF6), Packstone/grainstone oolítico (MF7), Grainstone com peloides (MF8), Grainstone com ooides rescristalizados (MF9) e Grainstone bioclástico (MF10). As microfácies foram agrupadas em 4 zonas faciológicas que remetem a instalação de uma plataforma carbonática com amplas planícies de marés com precipitação carbonática e evaporítica (sabkha), lagunas com circulação restrita e barras oolíticas/bioclásticas. Espessos depósitos interpretados como sabkha sugerem condições mais evaporíticas da plataforma carbonática quando comparados com exposições da borda sul da bacia. Os dados levantados nessa pesquisa, possuem caráter inédito e reforçam interpretações paleoambientais anteriores para a borda sul e auxiliam no refinamento da reconstrução das condições paleogeográficas da Formação Itaituba.

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Shokuhi Rad, Ali. "Application of B-=SUB=-12-=/SUB=-N-=SUB=-12-=/SUB=- and B-=SUB=-12-=/SUB=-P-=SUB=-12-=/SUB=- as two fullerene-like semiconductors for adsorption of halomethane: density functional theory study." Физика и техника полупроводников 51, no. 1 (2017): 134. http://dx.doi.org/10.21883/ftp.2017.01.44009.8191.

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We examined and discussed the interaction of two halomethanes (mono-chloromethane (MCM), and mono-fluoromethane (MFM) ) with B12N12 and B12P12 fullerene-like semiconductors based on density functional theory (DFT). We calculated adsorption energies and followed the changes in the electronic structure of semiconductors upon adsorption of MCM and MFM. We found that the adsorption on the B12N12 nano-cluster is energetically more favorable compared to B12P12 nano-cluster. Also for both systems we found higher values of adsorption energy for MFM than for MCM. We found that upon adsorption of above-mentioned species on these two fullerene-like semiconductors, the HOMO-LUMO distributions and also the gap energy for each system did not change significantly, which correspond to the physisorption process. As a result, B12N12 is a more appropriate nano-cluster to be used as a selective sensor for halomethanes, especially for MFM. DOI: 10.21883/FTP.2017.01.8191

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Dzhuguryan, Tygran, Agnieszka Deja, Bogusz Wiśnicki, and Zofia Jóźwiak. "The Design of Sustainable City Multi-Floor Manufacturing Processes Under Uncertainty in Supply Chains." Sustainability 12, no. 22 (November 13, 2020): 9439. http://dx.doi.org/10.3390/su12229439.

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The application of multi-floor manufacturing (MFM) in huge cities is related to the rational use of urban areas and the solution to traffic problems. The operation of the city MFM clusters depends on the efficiency of production and transport management considering technical, economic, environmental, and other factors. The primary goal of this paper was to identify and analyze the drivers of sustainable supply chains (SSCs) that influence or encourage the design of sustainable processes in city MFM clusters under uncertainty in supply chains. This paper presents an SSC performance model for city MFM clusters under uncertainty. The proposed model is universal and is based on material flow analysis (MFA) methodology. The presented analysis helps to determine the conditions for rhythmic deliveries with the use of the multi-IRTs. The coefficients of rhythmic deliveries for multiple intelligent reconfigurable trolleys (IRTs) and the capacity loss of freight elevators allow us to periodically assess the sustainability processes in city MFM clusters related to the flow materials. These assessments are the basis for the decision-making and planning of SSCs.

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Alireza, Shakeri, Douraghinejad Jalal, and Moradpour Mehran. "Microfacies and sedimentary environments of the late Oligocene-early Miocene Qom Formation of the Gooreh Berenji region (Jandaq area, central Iran)." GeoArabia 12, no. 4 (October 1, 2007): 41–60. http://dx.doi.org/10.2113/geoarabia120441.

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ABSTRACT The late Oligocene-early Miocene Qom Formation in the Central Iran Basin contains oil and gas in the Alborz and Sarajeh fields. Organic geochemical analyses in previous studies indicated that the hydrocarbons migrated from deeper source rocks, likely of Jurassic age. In the Central Iran Basin, the Qom Formation is 1,200 m thick and is bounded by the Oligocene Lower Red Formation and the middle Miocene Upper Red Formation. In previous studies, the Qom Formation was divided into nine members designated from oldest to youngest: a, b, c to c4, d, e and f, of which “e” is 300 m thick and constitutes the main reservoir. Our study focused on a Qom section located in the Gooreh Berenji region of central Iran which is 294 m thick. The lower part of the formation was not deposited, and only the following four members of early Miocene age (Aquitanian and Burdigalian) were identified between the Lower and Upper Red formations: “c2”? (mainly greyish to greenish gypsiferous marls); “d” (thin- to thick-bedded anhydrite with intercalation of thin-bedded sandstone); “e” (argillaceous or sandy limestone); and “f” (fine-grained coral and bryozoan boundstone). In contrast to the Central Iran Basin, the “e” member in Gooreh Berenji is only 15 m thick and does not have a good reservoir potential. A detailed petrographic analysis of the Gooreh Berenji section resulted in the identification of 13 microfacies (MF) that were interpreted in terms of their depositional environments according to the following categories: MF1 (sabkha), MF2 (intertidal river channel), MF3 (lower intertidal), MF4 (peritidal), MF5 (supratidal), MF6 and MF7 (shallow restricted lagoon), MF8 and MF10 (proximal open-marine), MF9 (leeward lagoon), MF11 (shoal), MF12 (reef and patch reef formed within lagoon), and MF13 (open-marine). The Qom Formation constitutes a regional transgressive-regressive sequence that is bounded by two continental units (Lower and Upper Red formations). The transgression started from the south in the late Oligocene and by the early Miocene the sea covered all of central Iran. In the Gooreh Berenji area, carbonate deposition occurred on a shallow-marine ramp. The presence of a wide range of lagoonal facies indicates that reefal facies (“f”) developed in a narrow elongated strip away from the shoreline.

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Hendi, Saif Ibrahim, and Nada Mahdi Fawzi Aljalawi. "Behavior of Reactive Powder Concrete reinforced with Hybrid Fibers containing Sustainable Materials." Engineering, Technology & Applied Science Research 14, no. 3 (June 1, 2024): 13878–82. http://dx.doi.org/10.48084/etasr.7167.

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This study investigates the behavior of recycled Reactive Powder Concrete (RPC), made from finely ground recycled raw materials and containing a certain percentage of recycled copper (electrical waste copper wire) and steel fibers. This concrete has a relatively low water-to-binder ratio and is composed of cement, fine aggregate, and ultrafine powders, such as quartz powder and silica fume. The properties of Fiber-Reinforced Reactive Powder Concrete (FR-RPC) containing micro-steel fibers, recycled copper fibers, and a mixture of steel-recycled and copper fibers were investigated. A micro-steel fiber RPC (MF1) was used as a reference mix, having 1% steel fibers by volume with 13 mm length and 0.2 mm diameter. Recycled copper fiber RPC (MF2) was prepared utilizing 1% recycled copper fibers by volume, with a diameter of 0.2 mm and a length of 10 mm. In addition, Hybrid FR-RPC (HFR-RPC) samples were prepared by mixing micro steel fibers and recycled copper fibers in proportions of 0.5-0.5% (MF3), 0.4-0.6% (MF4), and 0.3-0.7% (MF5), respectively. The compressive strength, flexural strength, and splitting tensile strength of these FR-RPC mixes were studied. The results displayed that MF3 achieved slightly lower compressive strength, flexural strength, and splitting tensile strength than MF1 and higher than MF2, MF4, and MF5. Although the mechanical strengths of MF3 were marginally lower than those of MF1, compressive strength, flexural strength, and splitting tensile strength were almost the same. Therefore, copper wire waste fibers can be employed along with steel fibers with excellent results.

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Valberg, Stephanie J., Sudeep Perumbakkam, Erica C. McKenzie, and Carrie J. Finno. "Proteome and transcriptome profiling of equine myofibrillar myopathy identifies diminished peroxiredoxin 6 and altered cysteine metabolic pathways." Physiological Genomics 50, no. 12 (December 1, 2018): 1036–50. http://dx.doi.org/10.1152/physiolgenomics.00044.2018.

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Equine myofibrillar myopathy (MFM) causes exertional muscle pain and is characterized by myofibrillar disarray and ectopic desmin aggregates of unknown origin. To investigate the pathophysiology of MFM, we compared resting and 3 h postexercise transcriptomes of gluteal muscle and the resting skeletal muscle proteome of MFM and control Arabian horses with RNA sequencing and isobaric tags for relative and absolute quantitation analyses. Three hours after exercise, 191 genes were identified as differentially expressed (DE) in MFM vs. control muscle with >1 log2 fold change (FC) in genes involved in sulfur compound/cysteine metabolism such as cystathionine-beta-synthase ( CBS, ↓4.51), a cysteine and neutral amino acid membrane transporter ( SLC7A10, ↓1.80 MFM), and a cationic transporter (SLC24A1, ↓1.11 MFM). In MFM vs. control at rest, 284 genes were DE with >1 log2 FC in pathways for structure morphogenesis, fiber organization, tissue development, and cell differentiation including > 1 log2 FC in cardiac alpha actin ( ACTC1 ↑2.5 MFM), cytoskeletal desmoplakin ( DSP ↑2.4 MFM), and basement membrane usherin ( USH2A ↓2.9 MFM). Proteome analysis revealed significantly lower antioxidant peroxiredoxin 6 content (PRDX6, ↓4.14 log2 FC MFM), higher fatty acid transport enzyme carnitine palmitoyl transferase (CPT1B, ↑3.49 MFM), and lower sarcomere protein tropomyosin (TPM2, ↓3.24 MFM) in MFM vs. control muscle at rest. We propose that in MFM horses, altered cysteine metabolism and a deficiency of cysteine-containing antioxidants combined with a high capacity to oxidize fatty acids and generate ROS during aerobic exercise causes chronic oxidation and aggregation of key proteins such as desmin.

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Dzhuguryan, Tygran, and Agnieszka Deja. "Sustainable Waste Management for a City Multifloor Manufacturing Cluster: A Framework for Designing a Smart Supply Chain." Sustainability 13, no. 3 (February 1, 2021): 1540. http://dx.doi.org/10.3390/su13031540.

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This study focuses on integrated sustainable waste management (ISWM) within a city multifloor manufacturing (MFM) cluster. Manufacturing activities in residential areas of the urban environment and the associated generation of municipal production waste (MPW) are serious problems. The primary goal of this study is to design smart supply chain (SSC) scenarios for the shipment of MPW from a city MFM cluster under uncertainty. This paper presents a new model of the finite MPW generation capacity for a city MFM cluster on the basis of an analysis of its finite production capacity using the material flow analysis (MFA) methodology. The proposed model allows us to determine the number of transport fleet units needed for the implementation of various supply chain (SC) scenarios of MPW. To select the best scenario for MPW shipment in real time, the application of SSC and SSC management (SSCM) technologies is proposed. SSCM performance indicators are proposed which allow us to evaluate the efficiency of using vehicles for cluster MPW transportation. The numerical values of the SSCM performance indicators for various options regarding the handling of city MFM buildings using trucks are obtained. These evaluations form the basis for the decision-making and planning associated with the SSCs of MPW.

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Nurgazizov, N., P. Zhdan, M. Kisielewski, and Feliks Stobiecki. "Investigation of Magnetization Distribution in Co/Au Multilayer Film by Magnetic Force Microscopy." Solid State Phenomena 152-153 (April 2009): 277–80. http://dx.doi.org/10.4028/www.scientific.net/ssp.152-153.277.

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Results obtained during examination of the multilayer Co/Au film by different methods of Magnetic Force Microscopy (MFM) are presented. It was shown, that double-pass scanning with MFM tips, characterised by strong magnetic moments resulted in a magnetisation reversal of the sample during MFM imaging. Single pass scanning or use of the MFM tips with low magnetic moments was required to minimise this process. Experimental results demonstrated good correlation between MFM results acquired during single-pass scanning and double-pass scanning with MFM tips characterised by low magnetic moment.

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Solihin, Iin, Ni Ketut Leni Meilani, and Retno Muninggar. "STRATEGI PENGELOLAAN PASAR IKAN MODERN DI PELABUHAN PERIKANAN SAMUDERA NIZAM ZACHMAN JAKARTA." Marine Fisheries : Journal of Marine Fisheries Technology and Management 11, no. 1 (April 22, 2021): 101–10. http://dx.doi.org/10.29244/jmf.v11i1.34855.

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Modern Fish Market (MFM) is the result of relocation from the Fish Marketing Center (FMC) located at the Nizam Zachman Ocean Fisheries Port in Jakarta (NZOFPJ). The relocation of the market has caused traders to protest against the manager. One of their actions is to go on a fish payment strike, which affects the stability MFM cash flow. Accordingly, the management needs to investigate the financial condition of MFM to determine future actions for the market sustainability. However, no study has been conducted regarding the financial condition of MFM. This study aims to determine the comparison of MFM and FMC revenue and strategies to improve the existing situation. A case study was conducted in the Nizam Zachman Fishing Port in Jakarta. Financial data of MFM and FMC including problems encountered by MFM were collected from the business division of Perum Perindo Jakarta, MFM management team and MFM traders. Revenue analysis, SWOT analysis as well as Quantitative Strategic Planning Matrix were perfomed in this study. The results showed that revenue generated by the MFM was IDR 1,474,085,972.00, which is lower than the FMC revenue (IDR 2,360,855,000.00). In order to improve MFM financial situation, nine strategies have been formulated and primarily it has been focused on the development of small and medium enterprises. Keywords: revenue, management, modern fish market, NZOFPJ, strategy.

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Sperling, Jeffrey, Rachel Shulman, Cinthia Blat, Edward Miller, Jolene Kokroko, Marya Zlatnik, Juan Gonzalez-Velez, Mary Norton, and Dana Gossett. "Gender Differences in Academic Rank and NIH Funding among Academic Maternal–Fetal Medicine Physicians in the United States." American Journal of Perinatology 36, no. 05 (November 10, 2018): 443–48. http://dx.doi.org/10.1055/s-0038-1675332.

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Objective This article evaluates gender differences in academic rank and National Institutes of Health (NIH) funding among academic maternal–fetal medicine (MFM) physicians. Study Design This was a cross-sectional study of board-certified academic MFM physicians. Physicians were identified in July 2017 from the MFM fellowship Web sites. Academic rank and receipt of any NIH funding were compared by gender. Data on potential confounders were collected, including years since board certification, region of practice, additional degrees, number of publications, and h-index. Results We identified 659 MFM physicians at 72 institutions, 312 (47.3%) male and 347 (52.7%) female. There were 246 (37.3%) full, 163 (24.7%) associate, and 250 (37.9%) assistant professors. Among the 154 (23.4%) MFM physicians with NIH funding, 89 (57.8%) were male and 65 (42.2%) were female (p = 0.003). Adjusting for potential confounders, male MFM physicians were twice as likely to hold a higher academic rank than female MFM physicians (adjusted odds ratio [aOR], 2.04 [95% confidence interval, 1.39–2.94], p < 0.001). There was no difference in NIH funding between male and female MFM physicians (aOR, 1.23 [0.79–1.92], p = 0.36). Conclusion Compared with female academic MFM physicians, male academic MFM physicians were twice as likely to hold a higher academic rank but were no more likely to receive NIH funding.

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. "MFM-website." Medisch-Farmaceutische Mededelingen 43, no. 2 (February 2005): 57. http://dx.doi.org/10.1007/bf03058552.

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Bormina, S. O., L. S. Korostovtseva, M. V. Bochkarev, Yu V. Sviryaev, A. O. Konradi, and V. M. Tikhonenko. "Multifunctional Monitoring: is it Possible to Simultaneously Evaluate Blood Pressure and Sleep‐Disordered Breathing?" Kardiologiia 60, no. 1 (February 6, 2020): 10–15. http://dx.doi.org/10.18087/cardio.2020.1.n482.

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Objective Carry out a comparative assessment of respiratory performance, based on multifunctional monitoring (MFM) and the recommended practice for complete polysomnography (PSG), and evaluate the effect of the blood pressure (BP) measurements in MFM on the quality of sleep.Materials and Methods At the first stage, 22 healthy volunteers (control group) underwent concomitant PSG and MFM, and 14 patients with suspected sleep-disordered breathing (SDB) underwent only PSG. At the second stage, concomitant PSG and MFM were performed in patients with confirmed SDB.Results In the control group, MFM detected a lower level of SpO2, a lower desaturation index (DI), and a higher apnea index (AI) than in the PSG group. However, the apnea-hypopnea index (AHI) was comparable in both groups. During concomitant PSG-MFM, the measurements of BP increased the number of micro-arousals only in the SDB group.Conclusion Results of the assessment of respiratory performance in MFM are comparable in both groups. The detected features of MFM indicators in the evaluation of the chest movements using rheopneumography, criteria different from that generally used for desaturation and hypoxemia, can lead to underestimation of desaturation and DI and underestimation of AI in the control group. The measurements of BP during sleep induced micro-arousals in the SDB group.

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Kose, Halil Cihan, and Serdar Onur Aydin. "Magnetic Resonance Imaging Evaluation of Multifidus Muscle in Patients with Low Back Pain after Microlumbar Discectomy Surgery." Journal of Clinical Medicine 12, no. 19 (September 22, 2023): 6122. http://dx.doi.org/10.3390/jcm12196122.

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Cross-sectional area (CSA) and signal intensity ratio (SIR) of the multifidus muscle (MFM) on magnetic resonance imaging (MRI) was used to evaluate the extent of injury and atrophy of the MFM in patients with negative treatment outcomes following microlumbar discectomy (MLD). Negative treatment outcome was determined by pain score improvement of <50% compared to baseline. Patients in groups 1, 2, and 3 were evaluated at <4 weeks, 4–24 weeks, and >24 weeks postoperatively, respectively. The associations between the follow-up, surgery time and the changes in the MFM were evaluated. A total of 79 patients were included, with 22, 27, and 30 subjects in groups 1, 2, and 3, respectively. The MFM SIR of the ipsilateral side had significantly decreased in groups 2 (p = 0.001) and 3 (p < 0.001). The ipsilateral MFM CSA significantly decreased postoperatively in groups 2 (p = 0.04) and 3 (p = 0.006). The postoperative MRI scans found significant MFM changes on the ipsilateral side in patients with negative treatment outcomes regarding pain intensity following MLD. As the interval to the postoperative MRI scan increased, the changes in CSA of the MFM and change in T2 SIR of the MFM showed a tendency to increase.

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Moreno-García, Manuel, Miguel Ángel Repullo-Ruibérriz de Torres, Rosa Carbonell-Bojollo, Javier López-Tirado, Luis Óscar Aguado-Martín, Antonio Rodríguez-Lizana, and Rafaela Ordóñez-Fernández. "Effects of Multifunctional Margins Implementation on Biodiversity in Annual Crops." Agronomy 11, no. 11 (October 28, 2021): 2171. http://dx.doi.org/10.3390/agronomy11112171.

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The most suitable land for agricultural use has been gradually occupied by crops around the world. Large, uninterrupted croplands have been created, while disproportionate amounts of fertilizers, insecticides, fungicides and herbicides are applied on them. As a result, agricultural activity has a negative impact on biodiversity the ecological intensification of cultivated lands has become necessary. Multifunctional Margins (MFM), the establishment of native flora margins adjacent to croplands, provide a semi-natural habitat for food and wildlife refuge. Three different species mixtures sown in MFM were studied in this paper. The large capacity of six species used in MFM (Borago officinalis, Glebionis coronaria, Coriandrum sativum, Sinapis alba, Trifolium resupinatum and Vicia sativa) was determined. Reductions of up to 65% in the appearance of weeds and increases of 36% in pollinator biodiversity in sown MFM with respect to the MFM of spontaneous flora were observed. The biodiversity of the epigeal fauna increased by 15% in the MFM of spontaneous flora and by 32% in sown MFM, with respect to annual crops.

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Frei, Guilherme Rodrigo, Jhonis Pessini, Nathieli Cozer, Aldi Feiden, Fábio Bittencourt, Wilson Boscolo, and Altevir Signor. "Mineral digestibility of different animal sources for the silver catfish Rhamdia voulezi." Latin American Journal of Aquatic Research 49, no. 3 (July 4, 2021): 476–84. http://dx.doi.org/10.3856/vol49-issue3-fulltext-2656.

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This study aimed to evaluate the apparent digestibility coefficients (ADCs) of dry matter, crude protein, gross energy, and minerals of marine fish meal (MFM), salmon meal (SM), tilapia by-product meal (TBM), meat and bone meal (MBM), poultry by-product meal (PBM), blood meal (BM), and feather meal (FM) by silver catfish Rhamdia voulezi. Groups of 12 fish were fed the experimental diet three times a day until apparent satiation, and the fecal samples were collected from an accumulation device. SM and PBM exhibited the highest digestibility values for dry matter, crude protein, and gross energy, while MBM and FM presented significantly lower ADCs for dry matter. BM and FM exhibited higher ADCs for phosphorus, 65.05 and 63.87%, respectively. The ADCs for calcium were 58.8% for MFM, 56.69% for TBM, and 60.08% for PBM. PBM and FM had the highest iron ADCs, 44.01 and 46.29%, respectively. Magnesium ADCs ranged from 44.87% for MBM to 75.50% for TBM. BM had the highest digestibility for zinc (62.77%), whereas MBM (36.68%) and FM (39.39%) had the lowest. In general, SM and PBM showed higher values as feedstuffs for silver catfish feeds. At the same time, the digestibility was lower for TBM and MBM for macronutrients and minerals such as phosphorus, iron, and zinc.

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Kley, Rudolf Andre, Yvonne Leber, Bertold Schrank, Heidi Zhuge, Zacharias Orfanos, Julius Kostan, Adekunle Onipe, et al. "FLNC-Associated Myofibrillar Myopathy." Neurology Genetics 7, no. 3 (June 2021): e590. http://dx.doi.org/10.1212/nxg.0000000000000590.

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ObjectiveTo determine whether a new indel mutation in the dimerization domain of filamin C (FLNc) causes a hereditary myopathy with protein aggregation in muscle fibers, we clinically and molecularly studied a German family with autosomal dominant myofibrillar myopathy (MFM).MethodsWe performed mutational analysis in 3 generations, muscle histopathology, and proteomic studies of IM protein aggregates. Functional consequences of the FLNC mutation were investigated with interaction and transfection studies and biophysics molecular analysis.ResultsEight patients revealed clinical features of slowly progressive proximal weakness associated with a heterozygous c.8025_8030delCAAGACinsA (p.K2676Pfs*3) mutation in FLNC. Two patients exhibited a mild cardiomyopathy. MRI of skeletal muscle revealed lipomatous changes typical for MFM with FLNC mutations. Muscle biopsies showed characteristic MFM findings with protein aggregation and lesion formation. The proteomic profile of aggregates was specific for MFM-filaminopathy and indicated activation of the ubiquitin-proteasome system (UPS) and autophagic pathways. Functional studies revealed that mutant FLNc is misfolded, unstable, and incapable of forming homodimers and heterodimers with wild-type FLNc.ConclusionsThis new MFM-filaminopathy family confirms that expression of mutant FLNC leads to an adult-onset muscle phenotype with intracellular protein accumulation. Mutant FLNc protein is biochemically compromised and leads to dysregulation of protein quality control mechanisms. Proteomic analysis of MFM protein aggregates is a potent method to identify disease-relevant proteins, differentiate MFM subtypes, evaluate the relevance of gene variants, and identify novel MFM candidate genes.

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Ehrmann, Andrea, and Tomasz Blachowicz. "Magnetic Force Microscopy on Nanofibers—Limits and Possible Approaches for Randomly Oriented Nanofiber Mats." Magnetochemistry 7, no. 11 (October 27, 2021): 143. http://dx.doi.org/10.3390/magnetochemistry7110143.

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Magnetic force microscopy (MFM) belongs to the methods that enable spatially resolved magnetization measurements on common thin-film samples or magnetic nanostructures. The lateral resolution can be much higher than in Kerr microscopy, another spatially resolved magnetization imaging technique, but since MFM commonly necessitates positioning a cantilever tip typically within a few nanometers from the surface, it is often more complicated than other techniques. Here, we investigate the progresses in MFM on magnetic nanofibers that can be found in the literature during the last years. While MFM measurements on magnetic nanodots or thin-film samples can often be found in the scientific literature, reports on magnetic force microscopy on single nanofibers or chaotic nanofiber mats are scarce. The aim of this review is to show which MFM investigations can be conducted on magnetic nanofibers, where the recent borders are, and which ideas can be transferred from MFM on other rough surfaces towards nanofiber mats.

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Sukmawati, S., P. Ponisri, Febrianti Rosalina, Anif Farida, Budi Satria, Ayu Diah Syafaati, and N. Nuryanto. "SKRINING BAKTERI METANOTROF, PELARUT POSFAT DAN NITROBACTER PADA LAHAN PERTANIAN KOTA SORONG." JURNAL GALUNG TROPIKA 11, no. 3 (December 23, 2022): 304–16. http://dx.doi.org/10.31850/jgt.v11i3.1049.

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Efek gas rumah kaca pada kehidupan sehari-hari dapat menyebabkan kerugian pada keseimbangan ekosistem serta mengancam keberlangsungan makhluk hidup. Salah-satunya gagal panen, komoditi pangan dan produk ekspor berkurang,sehingga menyebabkan kekurangan pangan, dan menurunkan taraf perekonomian masyarakat. Tujuan dari penelitian ini ialah pertama, untuk mendeteksi atau menskrining bakteri metanotrof, bakteri pelarut posfat, dan bakteri nitrobacter pada lahan pertanian kota Sorong. Kedua, untuk melihat pontensi bakteri metanotrof yang juga berpotensi sebagai bakteri pelarut posfat dan berpotensi sebagai bakteri nitrifikasi. Penelitian merupakan penelitian deskriptif, yaitu menguraikan hasil skrining bakteri metanotrof, bakteri pelarut posfat, dan bakteri nitrobacter. Selain daripada itu isolate bakteri metanotrof dikonfirmasi kemampuannya dalam menguraikan posfat dan kemampuannya dalam menfiksasi nitrogen. Hasil dari penelitian ini ialah, dari sepuluh sampel yang diamati, ditemukan lima sampel yang terdeteksi bakteri metanotrof yakni sampel MFa, MFb, MFc, MFd, dan sampel MFe. Selanjutnya, untuk bakteri pelarut posfat dan bakteri nitrobacter ditemukan pada sepuluh sampel yang diisolasi. Simpulan kedua, dari lima isolate bakteri metanotrof memiliki potensi dalam mengurai atau memanfaatkan posfat sebagai sumber energinya. Sedangkan dari lima isolate hanya tiga isolate yang mampu memanfaatkan nitrogen sebagai sumber energinya yakni isolat dengan kode MFa, isolat MFd, dan isolat MFe.

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Gui, Hai Lian, and Qing Xue Huang. "The Mixed Fast Multipole Boundary Element Method for Solving Strip Cold Rolling Process." Applied Mechanics and Materials 20-23 (January 2010): 76–81. http://dx.doi.org/10.4028/www.scientific.net/amm.20-23.76.

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Based on fast multipole boundary element method (FM-BEM) and mixed variational inequality, a new numerical method named mixed fast multipole boundary element method (MFM-BEM) was presented in this paper for solving three-dimensional elastic-plastic contact problems. Mixed boundary integral equation (MBIE) was the foundation of MFM-BEM and obtained by mixed variational inequality. In order to adapt the requirement of fast multipole method (FMM), Taylor series expansion was used in discrete MBIE. In MFM-BEM the calculation time was significant decreased, the calculation accuracy and continuity was also improved. These merits of MFM-BEM were demonstrated in numerical examples. MFM-BEM has broad application prospects and will take an important role in solving large-scale engineering problems.

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Chang, Ting-Yu, Kuan-Chi Wang, Hsien-Yang Liu, Jing-Hua Hseun, Wei-Cheng Peng, Nicolò Ronchi, Umberto Celano, Kaustuv Banerjee, Jan Van Houdt, and Tian-Li Wu. "Comprehensive Investigation of Constant Voltage Stress Time-Dependent Breakdown and Cycle-to-Breakdown Reliability in Y-Doped and Si-Doped HfO2 Metal-Ferroelectric-Metal Memory." Nanomaterials 13, no. 14 (July 19, 2023): 2104. http://dx.doi.org/10.3390/nano13142104.

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In this study, we comprehensively investigate the constant voltage stress (CVS) time-dependent breakdown and cycle-to-breakdown while considering metal-ferroelectric-metal (MFM) memory, which has distinct domain sizes induced by different doping species, i.e., Yttrium (Y) (Sample A) and Silicon (Si) (Sample B). Firstly, Y-doped and Si-doped HfO2 MFM devices exhibit domain sizes of 5.64 nm and 12.47 nm, respectively. Secondly, Si-doped HfO2 MFM devices (Sample B) have better CVS time-dependent breakdown and cycle-to-breakdown stability than Y-doped HfO2 MFM devices (Sample A). Therefore, a larger domain size showing higher extrapolated voltage under CVS time-dependent breakdown and cycle-to-breakdown evaluations was observed, indicating that the domain size crucially impacts the stability of MFM memory.

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Wang, Cunguo, Shengwei Zong, and Mai-He Li. "The Contrasting Responses of Mycorrhizal Fungal Mycelium Associated with Woody Plants to Multiple Environmental Factors." Forests 10, no. 11 (November 4, 2019): 973. http://dx.doi.org/10.3390/f10110973.

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Research Highlights: Extraradical mycorrhizal fungal mycelium (MFM) plays critical roles in nutrient absorption and carbon cycling in forest ecosystems. However, it is often ignored or treated as a root uptake apparatus in existing biogeochemical models. Methods: We conducted a meta-analysis to reveal how MFM responds to various, coinciding environmental factors and their interactions. Results: Nitrogen (N) addition and N-phosphorus (P)-potassium (K) combination significantly decreased MFM. However, elevated CO2, organic matter addition, P addition, and CO2-N combination significantly increased MFM. In contrast, warming, K addition, N-P combination, and P-K combination did not affect MFM. Mycorrhizal fungal levels (individual vs. community), mycorrhizal type (ectomycorrhizal fungi vs. arbuscular mycorrhizal fungi), treatment time (<1 year vs. >1 year), and mycelium estimation/sampling method (biomarker vs. non-biomarker; ingrowth mesh bag vs. soil core) significantly affected the responses of MFM to elevated CO2 and N addition. The effect sizes of N addition significantly increased with mean annual precipitation, but decreased with soil pH and host tree age. The effect sizes of P addition significantly increased with N concentration in host plant leaves. Conclusions: The differential responses revealed emphasize the importance of incorporating MFM in existing biogeochemical models to precisely assess and predict the impacts of global changes on forest ecosystem functions.

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Tasha, Ilir, Rachel Brook, Heidi Frasure, and Noam Lazebnik. "Prenatal Detection of Cardiac Anomalies in Fetuses with Single Umbilical Artery: Diagnostic Accuracy Comparison of Maternal-Fetal-Medicine and Pediatric Cardiologist." Journal of Pregnancy 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/265421.

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Aim. To determine agreement of cardiac anomalies between maternal fetal medicine (MFM) physicians and pediatric cardiologists (PC) in fetuses with single umbilical artery (SUA).Methods. A retrospective review of all fetuses with SUA between 1999 and 2008. Subjects were studied by MFM and PC, delivered at our institution, and had confirmation of SUA and cardiac anomaly by antenatal and neonatal PC follow-up. Subjects were divided into four groups: isolated SUA, SUA and isolated cardiac anomaly, SUA and multiple anomalies without heart anomalies, and SUA and multiple malformations including cardiac anomaly.Results. 39,942 cases were studied between 1999 and 2008. In 376 of 39,942 cases (0.94%), SUA was diagnosed. Only 182 (48.4%) met inclusion criteria. Cardiac anomalies were found in 21% (38/182). Agreement between MFM physicians and PC in all groups combined was 94% (171/182) (95% CI [89.2, 96.8]). MFM physicians overdiagnosed cardiac anomalies in 4.4% (8/182). MFM physicians and PC failed to antenatally diagnose cardiac anomaly in the same two cases.Conclusions. Good agreement was noted between MFM physicians and PC in our institution. Studies performed antenatally by MFM physicians and PC are less likely to uncover the entire spectrum of cardiac abnormalities and thus neonatal follow-up is suggested.

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Nicholas, Lauren D., Rebecca L. Fischbein, and Surya S. Bhamidipalli. "Twin anemia-polycythemia sequence and routine monitoring practices amongst maternal-fetal medicine specialists in the United States: an initial investigation." Journal of Perinatal Medicine 47, no. 4 (May 27, 2019): 388–92. http://dx.doi.org/10.1515/jpm-2018-0240.

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AbstractBackgroundThe purpose of this initial investigation was to begin to understand the routine twin anemia-polycythemia sequence (TAPS) monitoring practices of maternal-fetal medicine specialists (MFM specialists) in the United States in the absence of a formal guideline.MethodsThis study used an anonymous, online survey of 90 MFM specialists who were practicing in the United States. A $5 gift card to an online store was used to incentivize participants. Descriptive statistics were calculated.ResultsAll MFM specialists reported at least some familiarity (100.00%) with TAPS. Most participants (92.94%) were familiar with methods for monitoring patients for TAPS and nearly all (97.50%) responded that they use ‘Doppler MCA-PSV’ to make a prenatal TAPS diagnosis. Nearly two-thirds of MFM specialists surveyed (65.06%) reported performing regular TAPS monitoring for patients with monochorionic-diamniotic (MCDA) pregnancies.ConclusionDespite no formal guidelines, the majority of American MFM specialists surveyed are using routine TAPS screening in their management of MCDA twin pregnancies, suggesting that the MFM specialists included in this study consider it a valuable diagnostic tool. Future research should further explore this possible trend toward routine TAPS monitoring amongst MFM specialists in the United States, as well as the potential value of routine TAPS monitoring in MCDA pregnancy.

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Fernandes, Diana Carolina Lastra, Ana Catarina Fernandes Freitas, Sérgio Zenha, and Sara Cristina Cabral Freitas. "Anaesthetic management of caesarean section in a patient with myofibrillar myopathy." BMJ Case Reports 16, no. 12 (December 2023): e257198. http://dx.doi.org/10.1136/bcr-2023-257198.

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Myofibrillar myopathies (MFMs) are a group of rare genetic disorders that affect the function of skeletal, cardiac and smooth muscle.MFM exhibits a considerable degree of clinical heterogeneity. In numerous instances of MFM, muscle weakness is the predominant manifestation. Certain MFM subtypes are distinguished by respiratory and cardiac impairment.There is little information available about anaesthetic management in MFM, and even less is known about obstetric anaesthesia.A successful case of a patient with MFM undergoing a caesarean section under combined neuraxial anaesthesia is reported. The patient experienced no complications, and functional recovery was swift.

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Suzuki, K., S. Kitamura, and C. B. Mooney. "Observation of Magnetic Film Using Magnetic Force Microscope (MFM) in Ultra-High Vacuum (UHV)." Microscopy and Microanalysis 7, S2 (August 2001): 866–67. http://dx.doi.org/10.1017/s1431927600030403.

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In recent years, the magnetic force microscope (MFM) has been used not only for the evaluation of magnetic media but also for the measurement of magnetic characteristics of quantum dots as well as in various fields, because the MFM can visualize magnetic field on the sample surface with the high resolution. The MFM observation in ultra-high vacuum (UHV) requires to reduce the adsorption layer on the sample surface for high resolution observation. The slope detection mode using the variation of vibrating cantilever is basically unstable in UHV due to the increase in the Q factor of the cantilever. Accordingly it has been used for the MFM observation in air. On the other hand, the FM detection technique offers a very high sensitivity because of the high Q factor.This repot describes the MFM technique to take a magnetic image steadily in UHV. We observed the surface of a magnetic material with MFM technique in UHV, and compared the slope detection technique, the phase detection technique using phase variation of cantilever vibration, and the FM detection technique.

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Cambel, Vladimír, Dagmar Gregušová, Peter Eliáš, Ján Fedor, Ivan Kostič, Ján Maňka, and Peter Ballo. "Switching Magnetization Magnetic Force Microscopy — An Alternative to Conventional Lift-Mode MFM." Journal of Electrical Engineering 62, no. 1 (January 1, 2011): 37–43. http://dx.doi.org/10.2478/v10187-011-0006-2.

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Switching Magnetization Magnetic Force Microscopy — An Alternative to Conventional Lift-Mode MFM In the paper we present an overview of the latest progress in the conventional lift-mode magnetic force microscopy (MFM) technique, achieved by advanced MFM tips and by lowering the lift height. Although smaller lift height offers improved spatial resolution, we show that lowered tip-sample distance mixes magnetic, atomic and electric forces. We describe an alternative to the lift-mode procedure - Switching Magnetization Magnetic Force Microscopy [SM-MFM], which is based on two-pass scanning in tapping mode AFM with reversed tip magnetization between the scans. We propose design and calculate the magnetic properties of such SM-MFM tips. For best performance the tips must exhibit low magnetic moment, low switching field, and single-domain state at remanence. The switching field of such tips is calculated for Permalloy hexagons.

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Majchrzycka, Katarzyna, Małgorzata Okrasa, Anita Jachowicz, Justyna Szulc, Bogumił Brycki, and Beata Gutarowska. "Application of Biocides and Super-Absorbing Polymers to Enhance the Efficiency of Filtering Materials." Molecules 24, no. 18 (September 13, 2019): 3339. http://dx.doi.org/10.3390/molecules24183339.

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Studies on the functionalization of materials used for the construction of filtering facepiece respirators (FFRs) relate to endowing fibers with biocidal properties. There is also a real need for reducing moisture content accumulating in such materials during FFR use, as it would lead to decreased microorganism survival. Thus, in our study, we propose the use of superabsorbent polymers (SAPs), together with a biocidal agent (biohalloysite), as additives in the manufacturing of polypropylene/polyester (PP/PET) multifunctional filtering material (MFM). The aim of this study was to evaluate the MFM for stability of the modifier’s attachment to the polymer matrix, the degree of survival of microorganisms on the nonwoven, and its microorganism filtration efficiency. Scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy were used to test the stability of the modifier’s attachment. The filtration efficiency was determined under conditions of dynamic aerosol flow of S. aureus bacteria. The survival rates (N%) of the following microorganisms were assessed: Escherichia coli and Staphylococcus aureus bacteria, Candida albicans yeast, and Aspergillus niger mold using the AATCC 100-2004 method. FTIR spectrum analysis confirmed the pre-established composition of MFM. The loss of the active substance from MFM in simulated conditions of use did not exceed 0.02%, which validated the stability of the modifier’s attachment to the PP/PET fiber structure. SEM image analysis verified the uniformity of the MFM structure. Lower microorganism survival rates were detected for S. aureus, C. albicans, and E. coli on the MFM nonwoven compared to control samples that did not contain the modifiers. However, the MFM did not inhibit A. niger growth. The MFM also showed high filtration efficiency (99.86%) against S. aureus bacteria.

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Zhu, Xiaobin, and Peter Grütter. "Imaging, Manipulation, and Spectroscopic Measurements of Nanomagnets by Magnetic Force Microscopy." MRS Bulletin 29, no. 7 (July 2004): 457–62. http://dx.doi.org/10.1557/mrs2004.139.

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AbstractMagnetic force microscopy (MFM) is a well-established technique for imaging the magnetic structures of small magnetic particles. In cooperation with external magnetic fields, MFM can be used to study the magnetization switching mechanism of submicrometer-sized magnetic particles. Various MFM techniques allow the measurement of a hysteresis curve of an individual particle, which can then be compared to ensemble measurements. The advantage of using MFM-constructed hysteresis loops is that one can in principle understand the origin of dispersion in switching fields. It is also possible to directly observe the correlation between magnetic particles through careful imaging and control of the external magnetic field. In all of these measurements, attention needs to be paid to avoid artifacts that result from the unavoidable magnetic tip stray field. Control can be achieved by optimizing the MFM operation mode as well as the tip parameters. It is even possible to use the tip stray field to locally and reproducibly manipulate the magnetic-moment state of small particles. In this article, we illustrate these concepts and issues by studying various lithographically patterned magnetic nanoparticles, thus demonstrating the versatility of MFM for imaging, manipulation, and spectroscopic measurements of small particles.

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Leighton, Cassandra, Molly Conroy, Andrew Bilderback, Wendy Kalocay, James K. Henderson, and Hyagriv N. Simhan. "Implementation and Impact of a Maternal–Fetal Medicine Telemedicine Program." American Journal of Perinatology 36, no. 07 (October 31, 2018): 751–58. http://dx.doi.org/10.1055/s-0038-1675158.

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Objective The increase in maternal morbidity has resulted in higher need for maternal–fetal medicine (MFM) subspecialty care. To meet the rising demand, particularly in rural areas, the use of MFM telemedicine services has increased. This study describes the structure, implementation, and patient and child health outcomes associated with a large health system's MFM telemedicine program. Study Design Observational electronic health record data are used to compare maternal and childbirth outcomes between patients receiving care via telemedicine or in-person visits through regression analysis. Average patient time and resources saved are calculated, and patient satisfaction scores are reported. Results The telemedicine patients experienced similar outcomes to the in-person group, indicating that MFM telemedicine can serve as an effective substitute for in-person care. MFM telemedicine patients saved $90.28 per consult in travel and work-related expenses. An overwhelming majority of MFM telemedicine patients were satisfied with their visit and indicated that they would be interested in receiving care via telemedicine in the future. Conclusion The results indicate that the patients may benefit financially and experience similar outcomes when telemedicine programs are appropriately designed to eliminate access barriers and provide high-quality care.

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Fabri, Rodrigo Luiz, Danielle Maria de Oliveira Aragão, Jônatas Rodrigues Florêncio, Nícolas de Castro Campos Pinto, Ana Carolina Alves Mattos, Paulo Marcos Zech Coelho, Maria Christina Marques Nogueira Castañon, Eveline Gomes Vasconcelos, Priscila de Faria Pinto, and Elita Scio. "Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant SpeciesMitracarpus frigiduson AdultSchistosoma mansoniWorms." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/941318.

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The aims of this work were to evaluate thein vitroandin vivoschistosomicidal properties of the methanolic extract of the aerial parts ofMitracarpus frigidus(MFM) and to determine its HPLC profile. For thein vitroexperiment, four pairs of adult worms, obtained from infected mice, were exposed to different concentrations of MFM (100 to 400 μg/mL) for 24 and 48 h and analyzed under an inverted microscope. For thein vivoexperiment, mice were inoculated with cercariae and, 20 days after infection, MFM (100 and 300 mg/kg) was administered orally for the following 25 days. Mice were euthanized after 60 days. MFM showedin vitroschistosomicidal activity, exhibiting the opening of the gynaecophoral canal of some male schistosomes, the presence of contorted muscles, vesicles, and the darkening of the paired worms skin.In vivoexperiments showed that MFM treatments significantly reduced total worm count, as praziquantel, showing a decrease in liver and spleen weight. Also, a significant reduction in granuloma density was observed. MFM treatment did not cause alterations in the liver function of either infected or noninfected mice. The HPLC chromatogram profile showed the presence of kaempferol-O-rutinoside, rutin, kaempferol, psychorubrin, and ursolic acid.

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Antkiewicz, Maciej, Wiktor Kuliczkowski, Marcin Protasiewicz, Tomasz Zubilewicz, Piotr Terlecki, Magdalena Kobielarz, and Dariusz Janczak. "Aneurysm Sac Pressure during Branched Endovascular Aneurysm Repair versus Multilayer Flow Modulator Implantation in Patients with Thoracoabdominal Aortic Aneurysm." International Journal of Environmental Research and Public Health 19, no. 21 (November 6, 2022): 14563. http://dx.doi.org/10.3390/ijerph192114563.

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Open thoracoabdominal repair is the gold standard in the TAAA treatment. However, there are endovascular techniques, that sometimes may be an alternative, such as branched endovascular aneurysm repair (BEVAR) or implantation of the multilayer flow modulator (MFM). In this study, we aimed to assess differences in the aneurysm sac pressure (ASP) between patients undergoing BEVAR and MFM implantation. The study included 22 patients with TAAA (14 patients underwent BEVAR, while eight MFM implantation). The pressure sensor wire was placed inside the aneurysm. A measurement of ASP and aortic pressure (AP) was performed during the procedure. The systolic pressure index (SPI), diastolic pressure index (DPI), and pulse pressure index (PPI) were calculated as a quotient of the ASP and AP values. After the procedure, SPI and PPI were lower in the BEVAR group than in the MFM group. During a procedure, a drop in SPI and PPI was noted in patients undergoing BEVAR, while no changes were revealed in the MFM group. This indicates that BEVAR, but not MFM, is associated with a reduction in systolic and pulse pressure in the aneurysm sac in patients with TAAA.

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Jain, Deepti, Soma Banik, L. S. Sharath Chandra, S. R. Barman, R. Nath, and V. Ganesan. "Mapping of Magnetic Domains by MFM in Ni₂MnGa." Advanced Materials Research 52 (June 2008): 115–19. http://dx.doi.org/10.4028/www.scientific.net/amr.52.115.

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Influence of structural transition in the evolution of the magnetic domains in the ferromagnetic shape memory alloy system Ni2+xMn1-xGa is reported here using Magnetic Force Microscopy (MFM) studies. Studies reported are with two samples with their martensite transition temperature TM less than and greater than the Curie temperature Tc. Present results show an evolution of MFM across the Tc with a clear twin domains and sub domain structures inside the twins. The higher spatial resolution of MFM (~50nm) as compared to optical microscope (400nm) is useful in probing the domain walls. Force derivative of the MFM signal that may be used as an order parameter seems to scale the onset of magnetic order in the system. One can clearly see the vanishing of the MFM patterns for T>Tc. Results are discussed in the light of models available for tip-sample interactions that track the local magnetization.

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Gui, Hai Lian, Qing Xue Huang, Ya Qin Tian, and Zhi Bing Chu. "Application Incompatible Element in Mixed Fast Multipole Boundary Element Method." Key Engineering Materials 439-440 (June 2010): 80–85. http://dx.doi.org/10.4028/www.scientific.net/kem.439-440.80.

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Based on fast multipole boundary element method (FM-BEM) and mixed variational inequality, a new method named mixed fast multipole boundary element method (MFM-BEM) was presented in this paper. In order to improve calculation time and accuracy, incompatible elements as interpolation functions were used in the algorithm. Elements were optimized by mixed incompatible elements and compatible elements. On the one hand, the difficult to satisfy precise coordinate was avoided which caused by compatible elements; on the other hand, the merits of MFM-BEM were retained. Through analysis of example, it was conclusion that calculation time and accuracy were improved by MFM-BEM, calculation continuity was also better than traditional FM-BEM. With increasing of degree of freedom, calculation time of MFM-BEM grew slower than the time of traditional FM-BEM. So MFM-BEM provided a theoretical basis for solving large-scale engineering problems.

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Sasage, Kohei, Naoya Okamoto, Hana Tsujikawa, Takehiro Yamaoka, and Eiji Saitoh. "Magnetic Force Microscopic Study on Domain-Wall Molecules in NiFe Nano Rings." Solid State Phenomena 152-153 (April 2009): 529–32. http://dx.doi.org/10.4028/www.scientific.net/ssp.152-153.529.

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A pair of magnetic domain walls (DWs) in ferromagnetic NiFe rings has been investigated in terms of the magnetic force microscopy (MFM). When the distance between the rings d is greater than a threshold value dth, MFM signals indicate that a DW in the ring is dragged due to a stray magnetic field from an MFM probe tip. When d < dth, this drag signals disappears; DWs are bound to each other by the DW-DW interaction. This transition can be argued in terms of the competition between the DW-DW magnetostatic interaction and the DW-drag potential. From the d-dependent MFM data, the DW-drag potential was estimated.

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Vokoun, David, Sneha Samal, and Ivo Stachiv. "Magnetic Force Microscopy in Physics and Biomedical Applications." Magnetochemistry 8, no. 4 (April 9, 2022): 42. http://dx.doi.org/10.3390/magnetochemistry8040042.

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Magnetic force microscopy (MFM) enables to characterize magnetic properties with submicron (nanoscale) resolution and without much demand on sample surface preparation. MFM can operate in a wide range of temperatures and environmental conditions, that is, vacuum, liquid, or air, therefore this technique has already become the most common tool used to characterize variety of magnetic materials ranging from ferromagnetic thin films and 2D materials to biomedical and/or biological materials. The purpose of this review is to provide a summary of MFM basic fundamentals in the frame of other related methods and, correspondingly, a brief overview of physics and chiefly biomedical as well as biological applications of MFM.

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Campostrini, Eliemar, Heber Cruz Lima, Jurandi Gonçalves de Oliveira, Pedro Henrique Monnerat, and Cláudia Sales Marinho. "Teores de Ca e variáveis meteorológicas: relações com a incidência da mancha fisiológica do mamão no Norte Fluminense." Bragantia 64, no. 4 (2005): 601–13. http://dx.doi.org/10.1590/s0006-87052005000400010.

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No Brasil e no mundo, o mamoeiro (Carica papaya L.) tem apresentado um distúrbio fisiológico no fruto denominado de Mancha Fisiológica do Mamão (MFM). Na literatura, pouco se conhece sobre as causas desta anomalia que afeta sensivelmente a comercialização dos frutos da espécie. Com o objetivo de se buscar informações relacionadas às causas da MFM, foi realizado um estudo, durante um ano, em um plantio comercial localizado em São Franscisco do Itabapoana (RJ), no norte fluminense. Foram feitas relações entre algumas variáveis do clima (temperatura, déficit de pressão de vapor, precipitação pluvial e radiação solar global) e os teores de Ca na planta [limbo, pecíolo, pedúnculo, epicarpo não-exposto (face do fruto próxima ao tronco) e epicarpo exposto (face do fruto oposta ao tronco)] com a incidência da MFM. Observou-se que a maior incidência de MFM foi durante setembro/2000. Em janeiro/2001, a incidência da MFM foi praticamente nula. A amplitude térmica, nos três meses que antecederam a setembro/2000, foi a variável do clima que mais se relacionou com a incidência da MFM. Em setembro, os teores de Ca em todas as partes do fruto (pedúnculo, epicarpo exposto e não-exposto) estudadas foram maiores. Na época que antecedeu o mês de setembro, as relações Ca/K e Ca/Mg foram estatisticamente maiores no epicarpo exposto e não-exposto e, nesta época, a relação Ca/P foi estatisticamente maior no pedúnculo e no epicarpo não-exposto. Os efeitos da amplitude térmica sobre a incidência da MFM são discutidos e a hipótese de que os teores baixos de Ca no fruto poderiam causar desestabilização na parede celular, o que facilitaria o extravasamento do látex e provocaria a MFM, deve ser reavaliada.

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Fuhrmann, Marc, Anna Musyanovych, Ronald Thoelen, Sibylle von Bomhard, and Hildegard Möbius. "Magnetic Imaging of Encapsulated Superparamagnetic Nanoparticles by Data Fusion of Magnetic Force Microscopy and Atomic Force Microscopy Signals for Correction of Topographic Crosstalk." Nanomaterials 10, no. 12 (December 11, 2020): 2486. http://dx.doi.org/10.3390/nano10122486.

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Encapsulated magnetic nanoparticles are of increasing interest for biomedical applications. However, up to now, it is still not possible to characterize their localized magnetic properties within the capsules. Magnetic Force Microscopy (MFM) has proved to be a suitable technique to image magnetic nanoparticles at ambient conditions revealing information about the spatial distribution and the magnetic properties of the nanoparticles simultaneously. However, MFM measurements on magnetic nanoparticles lead to falsifications of the magnetic MFM signal due to the topographic crosstalk. The origin of the topographic crosstalk in MFM has been proven to be capacitive coupling effects due to distance change between the substrate and tip measuring above the nanoparticle. In this paper, we present data fusion of the topography measurements of Atomic Force Microscopy (AFM) and the phase image of MFM measurements in combination with the theory of capacitive coupling in order to eliminate the topographic crosstalk in the phase image. This method offers a novel approach for the magnetic visualization of encapsulated magnetic nanoparticles.

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Tupin, Simon, Kei Takase, and Makoto Ohta. "Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment." Fluids 7, no. 7 (June 30, 2022): 220. http://dx.doi.org/10.3390/fluids7070220.

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Decades after its introduction, endovascular aneurysm repair remains a challenging procedure with risks of collateral patency failure. Here, we investigate the ability of a porous stent, the Multilayer Flow Modulator (MFM), to maintain renal perfusion after a single or overlapping case. Silicone models representing an ideal infrarenal AAA geometry were used to analyze and compare three cases (control, single MFM and two overlapped MFMs). Micro-computed tomography was used to image the deployed MFM devices geometry and evaluate pore size and density along with porosity in both two (planimetric) and three dimensions (gravimetric). Laser particle image velocimetry (PIV) experiments were performed to image velocity and vorticity fields at the aorta-renal bifurcation. Flow experiments revealed renal arteries perfusion preservation in both single and overlapped cases. Microstructure analysis revealed an uneven distribution of wires in the MFM devices leading to local change in planimetric porosity and pore size. Overlap of a second MFM device led to a significant decrease in those 2D metrics but did not affect the gravimetric porosity and the branch perfusion. This first microstructure evaluation of MFM device combined with flow experiments revealed the ability of the device to preserve collateral flow thanks to a highly porous microstructure.

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Sakar, Baha, Sibylle Sievers, Alexander Fernández Scarioni, Felipe Garcia-Sanchez, İlker Öztoprak, Hans Werner Schumacher, and Osman Öztürk. "A Ti/Pt/Co Multilayer Stack for Transfer Function Based Magnetic Force Microscopy Calibrations." Magnetochemistry 7, no. 6 (June 1, 2021): 78. http://dx.doi.org/10.3390/magnetochemistry7060078.

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Magnetic force microscopy (MFM) is a widespread technique for imaging magnetic structures with a resolution of some 10 nanometers. MFM can be calibrated to obtain quantitative (qMFM) spatially resolved magnetization data in units of A/m by determining the calibrated point spread function of the instrument, its instrument calibration function (ICF), from a measurement of a well-known reference sample. Beyond quantifying the MFM data, a deconvolution of the MFM image data with the ICF also corrects the smearing caused by the finite width of the MFM tip stray field distribution. However, the quality of the calibration depends critically on the calculability of the magnetization distribution of the reference sample. Here, we discuss a Ti/Pt/Co multilayer stack that shows a stripe domain pattern as a suitable reference material. A precise control of the fabrication process, combined with a characterization of the sample micromagnetic parameters, allows reliable calculation of the sample’s magnetic stray field, proven by a very good agreement between micromagnetic simulations and qMFM measurements. A calibrated qMFM measurement using the Ti/Pt/Co stack as a reference sample is shown and validated, and the application area for quantitative MFM measurements calibrated with the Ti/Pt/Co stack is discussed.

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Ao, Xiao-Lin, Yi-Mo Liao, Hai-Yan Kang, Hong-Li Li, Tian He, Li-Kou Zou, Shu-Liang Liu, Shu-Juan Chen, Yong Yang, and Xing-Yan Liu. "Untargeted Metabolomics and Physicochemical Analysis Revealed the Quality Formation Mechanism in Fermented Milk Inoculated with Lactobacillus brevis and Kluyveromyces marxianus Isolated from Traditional Fermented Milk." Foods 12, no. 19 (October 9, 2023): 3704. http://dx.doi.org/10.3390/foods12193704.

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Traditional fermented milk from the western Sichuan plateau of China has a unique flavor and rich microbial diversity. This study explored the quality formation mechanism in fermented milk inoculated with Lactobacillus brevis NZ4 and Kluyveromyces marxianus SY11 (MFM), the dominant microorganisms isolated from traditional dairy products in western nan. The results indicated that MFM displayed better overall quality than the milk fermented with L. brevis NZ4 (LFM) and K. marxianus SY11 (KFM), respectively. MFM exhibited good sensory quality, more organic acid types, more free amino acids and esters, and moderate acidity and ethanol concentrations. Non-targeted metabolomics showed a total of 885 metabolites annotated in the samples, representing 204 differential metabolites between MFM and LFM and 163 between MFM and KFM. MFM displayed higher levels of N-acetyl-L-glutamic acid, cysteinyl serine, glaucarubin, and other substances. The differential metabolites were mainly enriched in pathways such as glycerophospholipid metabolism, arginine biosynthesis, and beta-alanine metabolism. This study speculated that L. brevis affected K. marxianus growth via its metabolites, while the mixed fermentation of these strains significantly changed the metabolism pathway of flavor-related substances, especially glycerophospholipid metabolism. Furthermore, mixed fermentation modified the flavor and quality of fermented milk by affecting cell growth and metabolic pathways.

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Xiang, Kui, Yubin Hou, Jihao Wang, Jing Zhang, Qiyuan Feng, Ze Wang, Wenjie Meng, Qingyou Lu, and Yalin Lu. "A piezoelectric rotatable magnetic force microscope system in a 10 T cryogen-free superconducting magnet." Review of Scientific Instruments 93, no. 9 (September 1, 2022): 093706. http://dx.doi.org/10.1063/5.0100662.

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We constructed a piezoelectric rotatable magnetic force microscope (MFM) that works in a 10 T cryogen-free superconducting magnet. The piezoelectric tube is deformed tangentially and drives a bearing under the inertial drive principle so the MFM head can obtain rotary movement. Due to the novel piezoelectric design, the MFM can be hung underneath the heat sink via a soft spring, and it can be rotated in a cryogen-free superconducting magnet so that the direction of the magnetic field can be changed from 0° to 90° continuously. The system functions in magnetic fields of up to 10 T in any direction relative to the tip–sample geometry. This is the first piezoelectric rotatable MFM ever reported. Using this homemade rotatable MFM, we imaged the structure of magnetic tracks on a commercial videotape. When the magnetic field angle changes from 0° to 90°, the magnetic moments on the tape and probe tip also rotate. A magnetic field strength of 0.8 T parallel to the sample surface is required to fully rotate the magnetic moment of the tip we used, but 0.8 T is not enough to fully rotate the magnetic moment of the sample. The piezoelectric rotatable MFM is expected to be widely used to study the anisotropy of magnetic materials due to its superiority in obtaining the same high field in and out of plane (compared with a vector magnet) as well as in maintaining the same scan area precisely (compared with a mechanical rotatable MFM, especially for atomic-scale scan areas).

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Futamoto, Masaaki, Tatsuya Hagami, Shinji Ishihara, Kazuki Soneta, and Mitsuru Ohtake. "Fabrication of Magnetic Tips for High-Resolution Magnetic Force Microscopy." Key Engineering Materials 543 (March 2013): 35–38. http://dx.doi.org/10.4028/www.scientific.net/kem.543.35.

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Effects of magnetic material, coating thickness, and tip radius on magnetic force microscope (MFM) spatial resolution have been systematically investigated. MFM tips are prepared by using an UHV sputtering system by coating magnetic materials on non-magnetic Si tips employing targets of Ni, Ni-Fe, Co, Fe, Fe-B, and Fe-Pd. MFM spatial resolutions better than 9 nm have been confirmed by employing magnetic tips coated with high magnetic moment materials with optimized thicknesses.

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Wieczorek, Agnieszka Anna, Derya Balci, Martin Schmidt-Hieber, Philipp Lohneis, Ulrike Heider, Antonio Pezzutto, and Igor Wolfgang Blau. "Patients with extramedullary manifestation of multiple myeloma: Prognostic factors and survival." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e18552-e18552. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e18552.

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e18552 Background: Multiple myeloma is a plasma cell dyscrasia that primarily involves bone marrow but also occurs in the soft tissues. While observing striking differences in clinical courses of patients with extramedullary plasmacytoma (EMP), solitary bone plasmacytoma (SBP), multifocal form of multiple myeloma (MFM) and multiple myeloma (MM), we wanted to assess prognostic factors and outcomes in those groups. This retrospective analysis was performed to evaluate response rate and overall survival (OS) of patients with extramedullary manifestations. Methods: We evaluated the data from 54 patients with MM (n=17), MFM (n=19), EMP (n=12) and SBP (n=6) treated at our institution from 1994-2012 and initially selected based on provided tissue samples. The MM control cohort was matched with regard to age, gender and prior treatment regimens. In 3 of 19 cases of MFM extramedullary locations were found at initial diagnosis. Two patients with EMP converted into MFM during the treatment. All EMP lesions arised in the upper aerodigestive tract. However extramedullary involvement in MFM was found in the head and neck (37%), chest (53%), abdomen (21%) and extremities (31%). Results: The 5-year OS rate was 92% in the patients with EMP. Whereas, 5-year OS rates of MM patients achieved 70.6%. MFM patients reached only 58% 5-year OS. The 5-year probability of progression was significantly higher in the group with MFM than EMP (89.5% vs 33%, p=0.0076, log rank test). Median progression free survival was 34 months for MM and 20 months for MFM (p=0.18). Conclusions: The 5-year progression free survival could be reached in 10 out of 12 patients with EMP. Two of the patients with primary EMP developed MFM. Moreover, the secondary development of extramedullary manifestation was associated with worse prognosis. Since the differences in the disease development cannot be easily predicted, there is an need of additional predictors that take into account different genetically determined risk status. Our retrospective analysis of genetic variations in this cohort of patients indicates the need of additional predictors in future randomized studies in these rare subtypes of MM.

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Chen, Xi, Zhongyue Zhang, Jin Chen, Sergei Sapchenko, Xue Han, Ivan da-Silva, Ming Li, et al. "Enhanced proton conductivity in a flexible metal–organic framework promoted by single-crystal-to-single-crystal transformation." Chemical Communications 57, no. 1 (2021): 65–68. http://dx.doi.org/10.1039/d0cc05270a.

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Rought, Peter, Christopher Marsh, Simona Pili, Ian P. Silverwood, Victoria García Sakai, Ming Li, Martyn S. Brown, et al. "Modulating proton diffusion and conductivity in metal–organic frameworks by incorporation of accessible free carboxylic acid groups." Chemical Science 10, no. 5 (2019): 1492–99. http://dx.doi.org/10.1039/c8sc03022g.

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He, Wen-Yu, Wei-Xin Ren, Lei Cao, and Quan Wang. "FEM Free Damage Detection of Beam Structures Using the Deflections Estimated by Modal Flexibility Matrix." International Journal of Structural Stability and Dynamics 21, no. 09 (May 19, 2021): 2150128. http://dx.doi.org/10.1142/s0219455421501285.

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The deflection of the beam estimated from modal flexibility matrix (MFM) indirectly is used in structural damage detection due to the fact that deflection is less sensitive to experimental noise than the element in MFM. However, the requirement for mass-normalized mode shapes (MMSs) with a high spatial resolution and the difficulty in damage quantification restricts the practicability of MFM-based deflection damage detection. A damage detection method using the deflections estimated from MFM is proposed for beam structures. The MMSs of beams are identified by using a parked vehicle. The MFM is then formulated to estimate the positive-bending-inspection-load (PBIL) caused deflection. The change of deflection curvature (CDC) is defined as a damage index to localize damage. The relationship between the damage severity and the deflection curvatures is further investigated and a damage quantification approach is proposed accordingly. Numerical and experimental examples indicated that the presented approach can detect damages with adequate accuracy at the cost of limited number of sensors. No finite element model (FEM) is required during the whole detection process.

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Johari, Saiful Azmi, Mastura Mohtar, Sharifah Aminah Syed Mohammad, Rohana Sahdan, Zurina Shaameri, Ahmad Sazali Hamzah, and Mohd Fazli Mohammat. "In VitroInhibitory and Cytotoxic Activity of MFM 501, a Novel Codonopsinine Derivative, against Methicillin-ResistantStaphylococcus aureusClinical Isolates." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/823829.

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28 new pyrrolidine types of compounds as analogues for natural polyhydroxy alkaloids of codonopsinine were evaluated for their anti-MRSA activity using MIC and MBC value determination assay against a panel ofS. aureusisolates. One pyrrolidine compound, MFM 501, exhibited good inhibitory activity with MIC value of 15.6 to 31.3 μg/mL against 55S. aureusisolates (43 MRSA and 12 MSSA isolates). The active compound also displayed MBC values between 250 and 500 μg/mL against 58S. aureusisolates (45 MRSA and 13 MSSA isolates) implying that MFM 501 has a bacteriostatic rather than bactericidal effect against both MRSA and MSSA isolates. In addition, MFM 501 showed no apparent cytotoxicity activity towards three normal cell lines (WRL-68, Vero, and 3T3) with IC50values of >625 µg/mL. Selectivity index (SI) of MFM 501 gave a value of >10 suggesting that MFM 501 is significant and suitable for furtherin vivoinvestigations. These results suggested that synthetically derived intermediate compounds based on natural products may play an important role in the discovery of new anti-infective agents against MRSA.

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Uršič, Hana, Matej Šadl, Uroš Prah, and Val Fišinger. "Magnetic Force Microscopy of Multiferroic Bulk Ceramic Oxides." Crystals 13, no. 5 (May 19, 2023): 838. http://dx.doi.org/10.3390/cryst13050838.

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Bulk multiferroic ceramics have been extensively studied due to their great potential for magneto-electric coupling applications such as low-power and multifunctional nano-electronic devices. In most of these studies the macroscopic magnetic performance was investigated, while the magnetic response on the micro- and nano-scale was not examined in detail. Local magnetic phenomena can be studied using magnetic force microscopy (MFM), a technique derived from atomic force microscopy. MFM measures the magnetic force between the magnetised tip and the magnetic sample. It is one of the most used methods to characterise the structure of ferromagnetic domains, because the sample preparation is simple, non-destructive and provides a relatively high-resolution image. In this review paper we focus on the MFM analyses of bulk multiferroic ceramics. The core of the article is divided into four sections: the introduction, the preparation of samples prior to MFM examination, the reviews of MFM analyses performed on bulk multiferroic ceramics with and without external magnetic fields, and finally the conclusions and an outlook for the future.

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Jahangiri, Mehdi, Vahid Gharibi, Enayat Berizi, Rosanna Cousins, Francesco Tessarolo, Morteza Sheykhshoaei, Saeed Jafari, and Masoud Rismanchian. "P-253 AN IN-DEPTH EVALUATION OF THE EFFECTIVENESS OF MEDICAL FACE MASKS WORN BY HEALTHCARE WORKERS IN IRAN DURING THE COVID-19 PANDEMIC." Occupational Medicine 74, Supplement_1 (July 1, 2024): 0. http://dx.doi.org/10.1093/occmed/kqae023.0825.

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Abstract Introduction The COVID-19 pandemic has led to an increase in the production of medical face masks (MFM) as an affordable solution for personal protection against the highly contagious respiratory coronavirus. However, many domestically produced masks were introduced into workplaces without going through quality control processes. The effectiveness of a large number of MFM produced in Iran was untested, so the study aimed to evaluate the performance of MFM produced in Iran that are used by healthcare workers. Methods The study used two laboratory setups to evaluate bacterial filtration efficiency and differential pressure according to Standard EN14683:2019, and to assess features of the melt-blown layer using scanning electron microscope images. Samples were taken from ten uncertified brands of MFM commonly used by healthcare workers and five certified brands of MFM. Results The quality factor of the Reference Sample was nearly twice as high as that of the Test Sample. There was a positive correlation between bacterial filtration efficiency and quality factor and melt-blown layer grammage, and a negative correlation between fiber diameter and porosity. Discussion There was a high positive correlation between layer grammage and quality factor. Conclusion The uncertified MFM provides insufficient protection for healthcare workers, as they typically do not meet the recognized Standard for use as personal protective equipment.

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Journal articles on the topic 'MFM'

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