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Journal articles on the topic 'Mfr1'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Blanco, Miguel A., Laetitia Pelloquin, and Sergio Moreno. "Fission yeast mfr1 activates APC and coordinates meiotic nuclear division with sporulation." Journal of Cell Science 114, no. 11 (2001): 2135–43. http://dx.doi.org/10.1242/jcs.114.11.2135.

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Meiosis is the developmental program by which sexually reproducing diploid organisms generate haploid gametes. In yeast, meiosis is followed by spore morphogenesis. These two events are normally coordinated in such a way that spore formation is dependent upon completion of the meiotic nuclear divisions. Here we describe a meiosis-specific protein, mfr1, that is involved in this coordination. mfr1 is an activator of the anaphase-promoting complex (APC), which is necessary for the rapid degradation of the cdc13 cyclin at the end of meiosis II, prior to the formation of spores. An mfr1 null mutan

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Ornitz, D. M., A. Yayon, J. G. Flanagan, C. M. Svahn, E. Levi, and P. Leder. "Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells." Molecular and Cellular Biology 12, no. 1 (1992): 240–47. http://dx.doi.org/10.1128/mcb.12.1.240.

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Heparin is required for the binding of basic fibroblast growth factor (bFGF) to high-affinity receptors on cells deficient in cell surface heparan sulfate proteoglycan. So that this heparin requirement could be evaluated in the absence of other cell surface molecules, we designed a simple assay based on a genetically engineered soluble form of murine FGF receptor 1 (mFR1) tagged with placental alkaline phosphatase. Using this assay, we showed that FGF-receptor binding has an absolute requirement for heparin. By using a cytokine-dependent lymphoid cell line engineered to express mFR1, we also s

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Ornitz, D. M., A. Yayon, J. G. Flanagan, C. M. Svahn, E. Levi, and P. Leder. "Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells." Molecular and Cellular Biology 12, no. 1 (1992): 240–47. http://dx.doi.org/10.1128/mcb.12.1.240-247.1992.

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Heparin is required for the binding of basic fibroblast growth factor (bFGF) to high-affinity receptors on cells deficient in cell surface heparan sulfate proteoglycan. So that this heparin requirement could be evaluated in the absence of other cell surface molecules, we designed a simple assay based on a genetically engineered soluble form of murine FGF receptor 1 (mFR1) tagged with placental alkaline phosphatase. Using this assay, we showed that FGF-receptor binding has an absolute requirement for heparin. By using a cytokine-dependent lymphoid cell line engineered to express mFR1, we also s

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Kimata, Yuu, Kenji Kitamura, Nicola Fenner, and Hiroyuki Yamano. "Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast." Molecular Biology of the Cell 22, no. 9 (2011): 1486–94. http://dx.doi.org/10.1091/mbc.e10-09-0774.

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Meiosis is a specialized form of cell division generating haploid gametes and is dependent upon protein ubiquitylation by the anaphase-promoting complex/cyclosome (APC/C). Accurate control of the APC/C during meiosis is important in all eukaryotic cells and is in part regulated by the association of coactivators and inhibitors. We previously showed that the fission yeast meiosis-specific protein Mes1 binds to a coactivator and inhibits APC/C; however, regulation of the Mes1-mediated APC/C inhibition remains elusive. Here we show how Mes1 distinctively regulates different forms of the APC/C. We

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Amiri, A., S. M. Heath, and N. A. Peres. "Phenotypic Characterization of Multifungicide Resistance in Botrytis cinerea Isolates from Strawberry Fields in Florida." Plant Disease 97, no. 3 (2013): 393–401. http://dx.doi.org/10.1094/pdis-08-12-0748-re.

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Chemical control has always been essential for the management of gray mold, caused by Botrytis cinerea, to ensure sustainable strawberry production. However, lack of knowledge about actual resistance development may have disastrous consequences and lead to severe epidemics such as the one that affected several strawberry fields in 2012 in Florida. In this study, we tested 392 isolates collected from Florida strawberry fields between 2010 and 2012 for their sensitivity to boscalid (Bosc), a succinate dehydrogenase inhibitor (SdhI); pyraclostrobin, a quinone outside inhibitor (QoI); boscalid + p

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McClelland, Carol M., Jianmin Fu, Gay L. Woodlee, Tara S. Seymour, and Brian L. Wickes. "Isolation and Characterization of the Cryptococcus neoformans MATa Pheromone Gene." Genetics 160, no. 3 (2002): 935–47. http://dx.doi.org/10.1093/genetics/160.3.935.

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Abstract Cryptococcus neoformans is a heterothallic basidiomycete with two mating types, MATa and MATα. The mating pathway of this fungus has a number of conserved genes, including a MATα-specific pheromone (MFα1). A modified differential display strategy was used to identify a gene encoding the MATa pheromone. The gene, designated MFa1, is 42 amino acids in length and contains a conserved farnesylation motif. MFa1 is present in three linked copies that span a 20-kb fragment of MATa-specific DNA and maps to the MAT-containing chromosome. Transformation studies showed that MFa1 induced filament

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Watanabe, Akihiko, Noriko Hatakeyama, Akihito Yasuoka, and Kazuo Onitake. "Distributions of fibroblast growth factor and the mRNA for its receptor,MFR1, in the developing testis of the medaka,Oryzias latipes." Journal of Experimental Zoology 279, no. 2 (1997): 177–84. http://dx.doi.org/10.1002/(sici)1097-010x(19971001)279:2<177::aid-jez8>3.0.co;2-l.

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8

Yamamoto, Ayumu, Kenji Kitamura, Daisuke Hihara, Yukinobu Hirose, Satoshi Katsuyama, and Yasushi Hiraoka. "Spindle checkpoint activation at meiosis I advances anaphase II onset via meiosis-specific APC/C regulation." Journal of Cell Biology 182, no. 2 (2008): 277–88. http://dx.doi.org/10.1083/jcb.200802053.

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During mitosis, the spindle assembly checkpoint (SAC) inhibits the Cdc20-activated anaphase-promoting complex/cyclosome (APC/CCdc20), which promotes protein degradation, and delays anaphase onset to ensure accurate chromosome segregation. However, the SAC function in meiotic anaphase regulation is poorly understood. Here, we examined the SAC function in fission yeast meiosis. As in mitosis, a SAC factor, Mad2, delayed anaphase onset via Slp1 (fission yeast Cdc20) when chromosomes attach to the spindle improperly. However, when the SAC delayed anaphase I, the interval between meiosis I and II s

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9

Mei, Z. X., R. Keppens, I. I. Roussev, and J. Lin. "Parametric study on kink instabilities of twisted magnetic flux ropes in the solar atmosphere." Astronomy & Astrophysics 609 (December 22, 2017): A2. http://dx.doi.org/10.1051/0004-6361/201730395.

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Aims. Twisted magnetic flux ropes (MFRs) in the solar atmosphere have been researched extensively because of their close connection to many solar eruptive phenomena, such as flares, filaments, and coronal mass ejections (CMEs). In this work, we performed a set of 3D isothermal magnetohydrodynamic (MHD) numerical simulations, which use analytical twisted MFR models and study dynamical processes parametrically inside and around current-carrying twisted loops. We aim to generalize earlier findings by applying finite plasma β conditions. Methods. Inside the MFR, approximate internal equilibrium is

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10

Amigo, Julio, Ming Yu, Camila O. dos Santos, et al. "Mitoferrin1 Transgenic Zebrafish Line Serves as a Model to Study Erythroid Cell Fate during Hematopoiesis." Blood 112, no. 11 (2008): 3576. http://dx.doi.org/10.1182/blood.v112.11.3576.3576.

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Abstract We previously identified the mitochondrial solute carrier, Mitoferrin1 (Slc25a37, Mfrn1) as the principal mitochondrial iron importer essential for heme and iron-sulfur (Fe-S) cluster synthesis in developing erythroblasts. Its closely related paralog, Mitoferrin2 (Slc25a28, Mfrn2) functions in an analogous role in non-erythroid cells. Zebrafish with mutations in Mfrn1 have defects in hemoglobinization and maturation of erythroid cells caused by defective acquisition of iron into the mitochondria (GC Shaw, et al., 2006 Nature 440:96–100). Mfrn1 is highly expressed in embryonic and defi

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Hou, Yijun, Jun Zhang, Ting Li, and Shuhong Yang. "Multi-flux-rope system in solar active regions." Proceedings of the International Astronomical Union 15, S354 (2019): 443–47. http://dx.doi.org/10.1017/s1743921319009967.

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AbstractMagnetic flux rope (MFR) is closely connected with solar eruptions, such as flares and coronal mass ejections. The classical scenario assumes a single MFR for each eruption, but it is reasonable to expect multiple MFRs in a complex active region (AR). Statistically investigating AR 11897, we verify the existence of multiple MFR proxies during the AR evolution. Recently, AR 12673 in 2017 September produced the two largest flares in Solar Cycle 24. The evolutions of the AR magnetic fields and the two large flares reveal that significant flux emergence and successive interactions between

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Sterczala, Adam J., Jonathan D. Miller, Michael A. Trevino, Hannah L. Dimmick, and Trent J. Herda. "Differences in the motor unit firing rates and amplitudes in relation to recruitment thresholds during submaximal contractions of the first dorsal interosseous between chronically resistance-trained and physically active men." Applied Physiology, Nutrition, and Metabolism 43, no. 8 (2018): 759–68. http://dx.doi.org/10.1139/apnm-2017-0646.

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Previous investigations report no changes in motor unit (MU) firing rates during submaximal contractions following resistance training. These investigations did not account for MU recruitment or examine firing rates as a function of recruitment threshold (REC). Therefore, MU recruitment and firing rates in chronically resistance-trained (RT) and physically active controls (CON) were examined. Surface electromyography signals were collected from the first dorsal interosseous during isometric muscle actions at 40% and 70% maximal voluntary contraction (MVC). For each MU, force at REC, mean firin

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Ziemer, Paulo G. P., Carlos A. Bulant, José I. Orlando, et al. "Automated lumen segmentation using multi-frame convolutional neural networks in intravascular ultrasound datasets." European Heart Journal - Digital Health 1, no. 1 (2020): 75–82. http://dx.doi.org/10.1093/ehjdh/ztaa014.

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Abstract Aims Assessment of minimum lumen areas in intravascular ultrasound (IVUS) pullbacks is time-consuming and demands adequately trained personnel. In this work, we introduce a novel and fully automated pipeline to segment the lumen boundary in IVUS datasets. Methods and results First, an automated gating is applied to select end-diastolic frames and bypass saw-tooth artefacts. Second, within a machine learning (ML) environment, we automatically segment the lumen boundary using a multi-frame (MF) convolutional neural network (MFCNN). Finally, we use the theory of Gaussian processes (GPs)

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Rijnboutt, S., G. Jansen, G. Posthuma, J. B. Hynes, J. H. Schornagel, and G. J. Strous. "Endocytosis of GPI-linked membrane folate receptor-alpha." Journal of Cell Biology 132, no. 1 (1996): 35–47. http://dx.doi.org/10.1083/jcb.132.1.35.

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GPI-linked membrane folate receptors (MFRs) have been implicated in the receptor-mediated uptake of reduced folate cofactors and folate-based chemotherapeutic drugs. We have studied the biosynthetic transport to and internalization of MFR isoform alpha in KB-cells. MFR-alpha was synthesized as a 32-kD protein and converted in a maturely glycosylated 36-38-kD protein 1 h after synthesis. 32-kD MFR-alpha was completely soluble in Triton X-100 at 0 degree C. In contrast, only 33% of the 36-38-kD species could be solubilized at these conditions whereas complete solubilization was obtained in Trito

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Kaneda, Ryo, Toshihiro Takahashi, Masayasu Takiguchi, Motoharu Hijikata, and Hiroshi Ito. "Thin-wall injection molding of high-density polyethylene for infrared radiation system lenses." Journal of Polymer Engineering 38, no. 3 (2018): 307–13. http://dx.doi.org/10.1515/polyeng-2017-0077.

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AbstractHigh-density polyethylene (HDPE) lenses are used for infrared radiation (IR) systems, such as radiation thermometers to transmit the IR of the 10 μm region. High IR transmittance and low visible ray (VR) transmittance are necessary for IR system lenses. This experimental investigation of thin-wall injection molding was conducted using 0.5 mm cavity thickness with a disk shape, finished to a mirror-like surface. As factors affecting transmittance, we evaluated the thickness, surface roughness, crystallinity, internal structure, and molecular chain orientation of molded parts, which were

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Hiemisch, Holger, A. Paula Monaghan, Günther Schütz, and Klaus H. Kaestner. "Expression of the mouse Fkh1/Mf1 and Mfh1 genes in late gestation embryos is restricted to mesoderm derivatives." Mechanisms of Development 73, no. 1 (1998): 129–32. http://dx.doi.org/10.1016/s0925-4773(98)00039-2.

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17

Vo, Ha Thi Mai, Monika Hartmann, and Nina Langen. "Rewarding the good and penalizing the bad? Consumers’ reaction to food retailers’ conduct." British Food Journal 120, no. 11 (2018): 2539–53. http://dx.doi.org/10.1108/bfj-06-2017-0339.

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Purpose The purpose of this paper is to obtain insights into Vietnamese consumers’ knowledge and relevance of as well as their reaction to modern food retailers (MFRs) responsible and irresponsible conduct. Design/methodology/approach Data were obtained from an online survey applying content analysis, uni- and multivariate tests and multivariate regression models. Findings In total, 60 percent of respondents are not aware of (ir)responsible conduct of MFR. Most of those aware of such behavior indicate that this has induced a change in their shopping behavior. This holds to a similar extent for

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Winnier, Glenn E., Tsutomu Kume, Keyu Deng, et al. "Roles for the Winged Helix Transcription Factors MF1 and MFH1 in Cardiovascular Development Revealed by Nonallelic Noncomplementation of Null Alleles." Developmental Biology 213, no. 2 (1999): 418–31. http://dx.doi.org/10.1006/dbio.1999.9382.

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Kume, T., K. Deng, and B. L. Hogan. "Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract." Development 127, no. 7 (2000): 1387–95. http://dx.doi.org/10.1242/dev.127.7.1387.

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The murine genes, Foxc1 and Foxc2 (previously, Mf1 and Mfh1), encode forkhead/winged helix transcription factors with virtually identical DNA-binding domains and overlapping expression patterns in various embryonic tissues. Foxc1/Mf1 is disrupted in the mutant, congenital hydrocephalus (Foxc1/Mf1(ch)), which has multiple developmental defects. We show here that, depending on the genetic background, most Foxc1 homozygous mutants are born with abnormalities of the metanephric kidney, including duplex kidneys and double ureters, one of which is a hydroureter. Analysis of embryos reveals that Foxc

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Paw, Barry H. "Iron Does Not “Jiggle Free” in Mitochondria: Is Mitoferrin the Only Answer?." Blood 112, no. 11 (2008): sci—27—sci—27. http://dx.doi.org/10.1182/blood.v112.11.sci-27.sci-27.

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The developing erythron requires tremendous amounts of iron (Fe) for the synthesis of heme for hemoproteins, such as hemoglobin, and iron-sulfur (Fe/S) clusters of proteins, which are required to catalyze redox reactions and regulate Fe uptake and storage. The uptake of Fe from transferrin (Tf) involves the binding of Tf to its cognate receptor (TfR), followed by the endocytosis of the Tf-TfR complex.1,2 In the late endosome, the release of Fe3+ from TfR is achieved by acidification of the vesicle by the v-ATPase H+-pump. Steap3 reduces the liberated Fe3+ prior to its transport out of the endo

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Chapman, Rod. "MF1." ACM SIGAda Ada Letters XXVII, no. 3 (2007): 5–6. http://dx.doi.org/10.1145/1315607.1315586.

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McFarlane, S. A., K. L. Gaustad, E. J. Mlawer, C. N. Long, and J. Delamere. "Development of a high spectral resolution surface albedo product for the ARM Southern Great Plains central facility." Atmospheric Measurement Techniques 4, no. 9 (2011): 1713–33. http://dx.doi.org/10.5194/amt-4-1713-2011.

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Abstract. We present a method for identifying dominant surface type and estimating high spectral resolution surface albedo at the Atmospheric Radiation Measurement (ARM) facility at the Southern Great Plains (SGP) site in Oklahoma for use in radiative transfer calculations. Given a set of 6-channel narrowband visible and near-infrared irradiance measurements from upward and downward looking multi-filter radiometers (MFRs), four different surface types (snow-covered, green vegetation, partial vegetation, non-vegetated) can be identified. A normalized difference vegetation index (NDVI) is used t

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McFarlane, S. A., K. L. Gaustad, E. J. Mlawer, C. N. Long, and J. Delamere. "Development of a high spectral resolution surface albedo product for the ARM Southern Great Plains central facility." Atmospheric Measurement Techniques Discussions 4, no. 3 (2011): 3097–145. http://dx.doi.org/10.5194/amtd-4-3097-2011.

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Abstract. We present a method for identifying dominant surface type and estimating high spectral resolution surface albedo at the Atmospheric Radiation Measurement (ARM) facility at the Southern Great Plains (SGP) site in Oklahoma for use in radiative transfer calculations. Given a set of 6-channel narrowband visible and near-infrared irradiance measurements from upward and downward looking multi-filter radiometers (MFRs), four different surface types (snow-covered, green vegetation, partial vegetation, non-vegetated) can be identified. A normalized difference vegetation index (NDVI) is used t

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Slotte, P. A. "Length scaling in MFRG." Journal of Physics A: Mathematical and General 20, no. 3 (1987): L177—L180. http://dx.doi.org/10.1088/0305-4470/20/3/011.

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Li, X., F. S. Wang, Z. Y. Wu, J. L. Lin, W. B. Lan, and J. H. Lin. "MicroRNA-19b targets Mfn1 to inhibit Mfn1-induced apoptosis in osteosarcoma cells." Neoplasma 61, no. 03 (2014): 265–73. http://dx.doi.org/10.4149/neo_2014_034.

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Chen, Wen, Liangtao Li, Nathaniel B. Langer, et al. "Abcb10 Physically Interacts with Mitoferrin1 to Enhance Its Stability for Heme Synthesis in the Erythroid Mitochondria." Blood 112, no. 11 (2008): 530. http://dx.doi.org/10.1182/blood.v112.11.530.530.

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Abstract We previously described a zebrafish mutant, frascati (frs), with hypochromic anemia and erythroid maturation arrest. Using positional cloning, we identified mitoferrin1 (mfrn1, slc25a37) as the gene disrupted in frs mutants (Shaw GC, et al. 2006 Nature 440:96–100). Mfrn1, the principle iron-importer in the mitochondria, is essential for heme and iron-sulphur (Fe/S) cluster syntheses in erythroblasts, and is required for primitive and definitive erythropoiesis. The biochemistry for Mfrn1-mediated iron acquisition into the mitochondria of developing erythroblasts, however, is poorly und

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Du, Mengyan, Si Yu, Wenhua Su, et al. "Mitofusin 2 but not mitofusin 1 mediates Bcl-XL-induced mitochondrial aggregation." Journal of Cell Science 133, no. 20 (2020): jcs245001. http://dx.doi.org/10.1242/jcs.245001.

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ABSTRACTBcl-2 family proteins, as central players of the apoptotic program, participate in regulation of the mitochondrial network. Here, a quantitative live-cell fluorescence resonance energy transfer (FRET) two-hybrid assay was used to confirm the homo-/hetero-oligomerization of mitofusins 2 and 1 (MFN2 and MFN1), and also demonstrate the binding of MFN2 to MFN1 with 1:1 stoichiometry. A FRET two-hybrid assay for living cells co-expressing CFP-labeled Bcl-XL (an anti-apoptotic Bcl-2 family protein encoded by BCL2L1) and YFP-labeled MFN2 or MFN1 demonstrated the binding of MFN2 or MFN1 to Bcl

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Shaw, George C., Nathaniel B. Langer, Yongming Wang, et al. "Abnormal Expression of Human Mitoferrin (SLC25A37) Is Associated with a Variant of Erythropoietic Protoporphyria." Blood 108, no. 11 (2006): 3. http://dx.doi.org/10.1182/blood.v108.11.3.3.

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Abstract Mitoferrin (mfrn, slc25a37) is the high-affinity transporter of iron into mitochondria of developing erythroblasts and is essential for normal erythropoiesis. Recently, we described the cloning and characterization of mfrn in the zebrafish frascati (frs) mutant, in which homozygous null mutation leads to profound hypochromic anemia and embryonic lethality (Shaw GC, et al. 2006 Nature 440:96–100). Here we characterize the human MFRN orthologue and implicate a specific disease process purportedly caused by defects in MFRN expression. We studied human MFRN expression by a) analysis of hu

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Takayanagi, Yuhei, Takeshi Kikuchi, Yoshiaki Hasegawa, et al. "Porphyromonas gingivalis Mfa1 Induces Chemokine and Cell Adhesion Molecules in Mouse Gingival Fibroblasts via Toll-Like Receptors." Journal of Clinical Medicine 9, no. 12 (2020): 4004. http://dx.doi.org/10.3390/jcm9124004.

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Porphyromonas gingivalis Mfa1 fimbriae are thought to act as adhesion factors and to direct periodontal tissue destruction but their immunomodulatory actions are poorly understood. Here, we investigated the effect of Mfa1 stimulation on the immune and metabolic mechanisms of gingival fibroblasts from periodontal connective tissue. We also determined the role of Toll-like receptor (TLR) 2 and TLR4 in Mfa1 recognition. Mfa1 increased the expression of genes encoding chemokine (C-X-C motif) ligand (CXCL) 1, CXCL3, intercellular adhesion molecule (ICAM) 1 and Selectin endothelium (E) in gingival f

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Paw, Barry H., Babette Gwynn, Nathaniel B. Langer, et al. "Targeted Disruption of the Mouse Mitoferrin (Slc25A37) Mitochondrial Solute Carrier Results in Defective Primitive and Definitive Erythropoiesis." Blood 108, no. 11 (2006): 265. http://dx.doi.org/10.1182/blood.v108.11.265.265.

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Abstract We previously described a zebrafish mutant, frascati (frs), which exhibits profound hypochromic anemia and erythroid maturation arrest due to defects in mitochondrial iron uptake. Through positional cloning, we showed that the frs gene encodes a novel member of the vertebrate mitochondrial solute carrier family (SLC25), mitoferrin (mfrn, slc25a37). Mfrn, which is highly expressed in fetal and adult hematopoietic tissues of zebrafish and mouse, functions as the major mitochondrial iron importer essential for heme biosynthesis in vertebrate erythroblasts (Shaw GC, et al. 2006 Nature 440

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Hasegawa, Yoshiaki, Jun Iwami, Keiko Sato, et al. "Anchoring and length regulation of Porphyromonas gingivalis Mfa1 fimbriae by the downstream gene product Mfa2." Microbiology 155, no. 10 (2009): 3333–47. http://dx.doi.org/10.1099/mic.0.028928-0.

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Porphyromonas gingivalis, a causative agent of periodontitis, has at least two types of thin, single-stranded fimbriae, termed FimA and Mfa1 (according to the names of major subunits), which can be discriminated by filament length and by the size of their major fimbrilin subunits. FimA fimbriae are long filaments that are easily detached from cells, whereas Mfa1 fimbriae are short filaments that are tightly bound to cells. However, a P. gingivalis ATCC 33277-derived mutant deficient in mfa2, a gene downstream of mfa1, produced long filaments (10 times longer than those of the parent), easily d

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Chen, Wen, Harry A. Dailey, and Barry H. Paw. "Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis." Blood 116, no. 4 (2010): 628–30. http://dx.doi.org/10.1182/blood-2009-12-259614.

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AbstractIn erythroid cells, ferrous iron is imported into the mitochondrion by mitoferrin-1 (Mfrn1). Previously, we showed that Mfrn1 interacts with Abcb10 to enhance mitochondrial iron importation. Herein we have derived stable Friend mouse erythroleukemia (MEL) cell clones expressing either Mfrn1-FLAG or Abcb10-FLAG and by affinity purification and mass spectrometry have identified ferrochelatase (Fech) as an interacting protein for both Mfrn1 and Abcb10. Fech is the terminal heme synthesis enzyme to catalyze the insertion of the imported iron into protoporphyrin IX to produce heme. The Mfrn

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Zhang, Ze, Tian-En Li, Mo Chen, et al. "MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming." British Journal of Cancer 122, no. 2 (2019): 209–20. http://dx.doi.org/10.1038/s41416-019-0658-4.

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Abstract Background Mitochondrial dynamics plays an important role in tumour progression. However, how these dynamics integrate tumour metabolism in hepatocellular carcinoma (HCC) metastasis is still unclear. Methods The mitochondrial fusion protein mitofusin-1 (MFN1) expression and its prognostic value are detected in HCC. The effects and underlying mechanisms of MFN1 on HCC metastasis and metabolic reprogramming are analysed both in vitro and in vivo. Results Mitochondrial dynamics, represented by constant fission and fusion, are found to be associated with HCC metastasis. High metastatic HC

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Park, Yoonsuk, M. Regina Simionato, Kachiko Sekiya, et al. "Short Fimbriae of Porphyromonas gingivalis and Their Role in Coadhesion with Streptococcus gordonii." Infection and Immunity 73, no. 7 (2005): 3983–89. http://dx.doi.org/10.1128/iai.73.7.3983-3989.2005.

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ABSTRACT Porphyromonas gingivalis, one of the causative agents of adult periodontitis, attaches and forms biofilms on substrata of Streptococcus gordonii. Coadhesion and biofilm development between these organisms requires the interaction of the short fimbriae of P. gingivalis with the SspB streptococcal surface polypeptide. In this study we investigated the structure and binding activities of the short fimbriae of P. gingivalis. Electron microscopy showed that isolated short fimbriae have an average length of 103 nm and exhibit a helical structure with a pitch of ca. 27 nm. Mfa1, the major pr

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Miller, Jonathan D., Adam J. Sterczala, Michael A. Trevino, and Trent J. Herda. "Examination of muscle composition and motor unit behavior of the first dorsal interosseous of normal and overweight children." Journal of Neurophysiology 119, no. 5 (2018): 1902–11. http://dx.doi.org/10.1152/jn.00675.2017.

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We examined differences between normal weight (NW) and overweight (OW) children aged 8–10 yr in strength, muscle composition, and motor unit (MU) behavior of the first dorsal interosseous. Ultrasonography was used to determine muscle cross-sectional area (CSA), subcutaneous fat (sFAT), and echo intensity (EI). MU behavior was assessed during isometric muscle actions at 20% and 50% of maximal voluntary contraction (MVC) by analyzing electromyography amplitude (EMGRMS) and relationships between mean firing rates (MFR), recruitment thresholds (RT), and MU action potential amplitudes (MUAPsize) an

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Key, Roger. "MFR — Past and future?" Pensions: An International Journal 7, no. 3 (2002): 207–10. http://dx.doi.org/10.1057/palgrave.pm.5940196.

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Chen, Hsiuchen, Scott A. Detmer, Andrew J. Ewald, Erik E. Griffin, Scott E. Fraser, and David C. Chan. "Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development." Journal of Cell Biology 160, no. 2 (2003): 189–200. http://dx.doi.org/10.1083/jcb.200211046.

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Mitochondrial morphology is determined by a dynamic equilibrium between organelle fusion and fission, but the significance of these processes in vertebrates is unknown. The mitofusins, Mfn1 and Mfn2, have been shown to affect mitochondrial morphology when overexpressed. We find that mice deficient in either Mfn1 or Mfn2 die in midgestation. However, whereas Mfn2 mutant embryos have a specific and severe disruption of the placental trophoblast giant cell layer, Mfn1-deficient giant cells are normal. Embryonic fibroblasts lacking Mfn1 or Mfn2 display distinct types of fragmented mitochondria, a

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Li, Ji-Chen, Hui-Ren Zhu, Cun-Liang Liu, Lin Ye, and Dao-En Zhou. "Experimental Study on Film Cooling Effectiveness of Blade With Chevron-Shaped Holes Under Wake Influence." Journal of Turbomachinery 143, no. 8 (2021). http://dx.doi.org/10.1115/1.4050449.

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Abstract Gas turbines have been widely used. With the continuous improvement of the performance of gas turbines, the turbine inlet temperature has greatly exceeded the heat-resistance limit of the turbine blade material, so advanced cooling technology is required. The film cooling effectiveness distribution over the blade under the effect of wake was obtained by the pressure-sensitive paint (PSP) technique. The test blade has five rows of chevron film holes on the pressure side, three rows of cylindrical film holes on the leading edge, and three rows of chevron film holes on the suction side.

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Yamamoto, A., M. Nagao, K. Ando, et al. "High-risk plaque burdens myocardial flow reserve in intermediate coronary artery disease: hybrid analysis of 13N-ammonia PET and coronary CT angiography." European Heart Journal 41, Supplement_2 (2020). http://dx.doi.org/10.1093/ehjci/ehaa946.0288.

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Abstract Background 13N-ammonia PET (NH3-PET) can detect myocardial perfusion abnormalities in patients with coronary artery disease (CAD) and also obtain diagnostic quantitative values of absolute myocardial blood flow and myocardial flow reserve (MFR). Low MFR (MFR&lt;2.0) is an independent prognostic factor for major adverse cardiac event in patients with ischemic and non-ischemic heart disease. A feature of low attenuation plaque (LAP) on coronary CT angiography (CCTA) has been known as high-risk plaque (HRP) for acute coronary syndrome even if there is no significant coronary stenosis

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"MFRI Inc, USA." Filtration Industry Analyst 1997, no. 6 (1997): 7. http://dx.doi.org/10.1016/s1365-6937(97)90710-3.

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"MFRI Inc, USA." Filtration Industry Analyst 1998, no. 16 (1998): 9. http://dx.doi.org/10.1016/s1365-6937(98)90326-4.

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"MFRI Inc, USA." Filtration Industry Analyst 1999, no. 31 (1999): 7. http://dx.doi.org/10.1016/s1365-6937(99)80013-6.

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"MFRI Inc, USA." Filtration Industry Analyst 1999, no. 29 (1999): 7. http://dx.doi.org/10.1016/s1365-6937(99)90078-3.

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"MFRI Inc, USA." Filtration Industry Analyst 1999, no. 27 (1999): 8. http://dx.doi.org/10.1016/s1365-6937(99)90186-7.

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"MFRI Inc, USA." Filtration Industry Analyst 2002, no. 11 (2002): 8. http://dx.doi.org/10.1016/s1365-6937(02)01128-0.

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"MFRI Inc, USA." Filtration Industry Analyst 2002, no. 7 (2002): 8. http://dx.doi.org/10.1016/s1365-6937(02)07026-0.

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"MFRI Inc, USA." Filtration Industry Analyst 2003, no. 5 (2003): 7. http://dx.doi.org/10.1016/s1365-6937(03)00531-8.

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"MFRI Inc, USA." Filtration Industry Analyst 2003, no. 7 (2003): 8. http://dx.doi.org/10.1016/s1365-6937(03)00733-0.

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"MFRI Inc USA." Filtration Industry Analyst 2003, no. 10 (2003): 8. http://dx.doi.org/10.1016/s1365-6937(03)01030-x.

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"MFRI Inc, USA." Filtration Industry Analyst 2004, no. 1 (2004): 9. http://dx.doi.org/10.1016/s1365-6937(04)00075-9.

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