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Journal articles on the topic 'MGIT-TB'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Choerunisa, Towifah Fauziah, Leni Lismayanti, Tiene Rostini, Ryan Bayusantika, and Ida Parwati. "Comparison of Line Probe Assay (LPA) and Mycobacterium Growth Indicator Tubes (MGIT) Assay for Second-line TB Drug Susceptibility Testing." Indonesian Biomedical Journal 13, no. 3 (2021): 256–60. http://dx.doi.org/10.18585/inabj.v13i3.1521.

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BACKGROUND: Tuberculosis (TB) infection is one of the most prominent health issues in the world, including in Indonesia. TB is evolving into multidrug-resistant tuberculosis (MDR-TB) and requiring second-line TB drugs. Mycobacterium growth indicator tube (MGIT) is the gold standard for susceptibility testing of second-line TB drugs. Alternatively, line probe assay (LPA), which detects genes resistant to second-line TB drugs, takes a shorter time to run. This study aims to compare MGIT and LPA's ability to detect TB resistance to second-line TB drugs and observe mutation patterns of genes encod

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Tania, Tryna, Pratiwi Sudarmono, R. Lia Kusumawati, et al. "Whole-genome sequencing analysis of multidrug-resistant Mycobacterium tuberculosis from Java, Indonesia." Journal of Medical Microbiology 69, no. 7 (2020): 1013–19. http://dx.doi.org/10.1099/jmm.0.001221.

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Introduction. Multidrug-resistant tuberculosis (MDR-TB) is a major public health problem globally, including in Indonesia. Whole-genome sequencing (WGS) analysis has rarely been used for the study of TB and MDR-TB in Indonesia. Aim. We evaluated the use of WGS for drug-susceptibility testing (DST) and to investigate the population structure of drug-resistant Mycobacterium tuberculosis in Java, Indonesia. Methodology. Thirty suspected MDR-TB isolates were subjected to MGIT 960 system (MGIT)-based DST and to WGS. Phylogenetic analysis was done using the WGS data. Results obtained using MGIT-base

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Zhao, Ping, Qin Yu, and Yu Zhang. "Evaluation of a manual identification system for detection of Mycobacterium tuberculosis in a primary tuberculosis laboratory in China." Journal of International Medical Research 47, no. 6 (2019): 2666–73. http://dx.doi.org/10.1177/0300060519844399.

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Objective To compare the diagnostic performance of the manual BACTEC™ Mycobacteria Growth Indicator Tube (MGIT™) system (M-MGIT) with the automated BACTEC™ MGIT™ 960 system (A-MGIT) and Löwenstein-Jensen (L-J) culture method in detecting mycobacteria in sputum specimens from patients with suspected pulmonary tuberculosis (TB). Methods For this cross-sectional study, sputum samples were taken from patients aged ≥18 years attending a TB clinic in Beijing, China between July 2015 and October 2016. Processed sputum samples were inoculated into the MGIT systems and L-J medium for up to 6 and 8 week

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Hanna, Bruce A., Adeleh Ebrahimzadeh, L. Bruce Elliott, et al. "Multicenter Evaluation of the BACTEC MGIT 960 System for Recovery of Mycobacteria." Journal of Clinical Microbiology 37, no. 3 (1999): 748–52. http://dx.doi.org/10.1128/jcm.37.3.748-752.1999.

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We evaluated the BACTEC MGIT 960 system, which is a fully automated, noninvasive system for the growth and detection of mycobacteria with a capacity to incubate and continuously monitor 960 7-ml culture tubes. We studied 3,330 specimens, 2,210 respiratory and 1,120 nonrespiratory specimens, collected from 2,346 patients treated at six sites. Processed specimens were inoculated into the BACTEC MGIT 960 and BACTEC 460 TB systems, as well as onto Lowenstein-Jensen slants and Middlebrook 7H11/7H11 selective plates. From all culture systems, a total of 362 isolates of mycobacteria were recovered; t

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Jorwal, Pankaj, Binit Kumar Singh, Ankita Anand, et al. "Diagnostics Evaluation of Smart Sure™ Mycobacterium tuberculosis Screening Kit and Smart Sure™ Multidrug-resistant Tuberculosis Detection Kit on Nonsputum Specimens at a Tertiary Care Center of North India." International Journal of Mycobacteriology 13, no. 3 (2024): 275–81. http://dx.doi.org/10.4103/ijmy.ijmy_140_24.

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Background: Tuberculosis (TB) is caused due to the infection of Mycobacterium tuberculosis (MTB) and it can infect the various parts of the human body. The disease is highly prevalent and is the second most common cause of death worldwide after COVID-19. Apart from sputum specimen, it is exceedingly difficult to diagnose due to its paucibacillary nature. The current study was intended to evaluate the accuracy of Smart Sure™ MTB and multidrug-resistant-TB (MDR-TB) kits (Genetix Biotech Asia Pvt. Ltd., India) with Xpert ultra and Mycobacterium growth indicator tube (MGIT) culture on nonsputum sp

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Makamure, Beauty, Salome Makumbirofa, Tsitsi Bandason, et al. "A suggested algorithm for detection of multi drug-resistant tuberculosis in Zimbabwe." Journal of Infection in Developing Countries 11, no. 08 (2017): 611–18. http://dx.doi.org/10.3855/jidc.8009.

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Introduction: Rapid genotypic and phenotypic methods for multi-drug-resistant-tuberculosis (MDR-TB) detection are now widely available. Zimbabwe adopted the use of GeneXpert-MTB/RIF, microscopic-observation-drug-susceptibility-assay (MODS) and Mycobacteria-Growth-Indicator-Tube (MGIT) drug-susceptibility-testing (DST). Data is limited on the ideal combination of use of these methods in resource limited settings. Methodology: Between August 2014 to July 2015, 211 sputa from MDR-TB suspects were tested with GeneXpert-MTB/RIF, MODS, manual-MGIT and Lowenstein-Jensen (LJ)-DST to determine di

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Rahman, S. M. Mazidur, Md Fahim Ather, Rumana Nasrin, et al. "Performance of WHO-Endorsed Rapid Tests for Detection of Susceptibility to First-Line Drugs in Patients with Pulmonary Tuberculosis in Bangladesh." Diagnostics 12, no. 2 (2022): 410. http://dx.doi.org/10.3390/diagnostics12020410.

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The fast and accurate detection of susceptibility in drugs is a major challenge for a successful tuberculosis (TB) control programme. This study evaluated the performance of WHO-endorsed rapid diagnostic tools, such as BACTEC MGIT 960 SIRE (MGIT SIRE), GenoType MTBDRplus (MTBDRplus) and Xpert MTB/RIF (Xpert), for detecting susceptibility to first-line anti-TB drugs among pulmonary TB patients in Bangladesh. A total of 825 sputum samples with results from drug susceptibility testing (DST) against first-line anti-TB drugs in the MGIT SIRE, MTBDRplus and Xpert assays were evaluated and compared w

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Rajani, Monika, and Molay Banerjee. "Evaluation of Various Diagnostic Techniques for the Diagnosis of Pulmonary and Extra Pulmonary Tuberculosis at a Tertiary Care Center in North India." Infectious Disorders - Drug Targets 20, no. 4 (2020): 433–39. http://dx.doi.org/10.2174/1871526519666191011165702.

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Introduction: Tuberculosis (TB) is a one of the main causes of mortality and morbidity worldwide. Bactec MGIT (Mycobacteria Growth Indicator Tube) system is a rapid, reliable automated system for early diagnosis of pulmonary and extra pulmonary TB in setups where purchase of expensive instruments is not possible. The present study was thus carried out to evaluate AFB microscopy, culture on Lowenstein Jensen media and micro MGIT system for early and accurate diagnosis of Tuberculosis. Methods: A total of 280 samples were processed for direct AFB smear examination, and culture on micro MGIT and

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Vater, Maria Claudia, Mário Motta Maximo, Adriana da Silva Rezende Moreira, Suely Conceição Alves da Silva, Isabela Neves de Almeida, and Afrânio Lineu Kritski. "Cost Analysis for Patients with Presumed Pulmonary Tuberculosis Attended in the Public Health System of Rio de Janeiro, Brazil." International Journal of Mycobacteriology 10, no. 2 (2021): 136–41. http://dx.doi.org/10.4103/ijmy.ijmy_58_21.

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Background: In last years, few attention has given to the patient's prediagnostic costs when evaluating the introduction of new technologies for tuberculosis (TB) and in this context, this study evaluated patient's costs and cost-effectiveness incurred with TB diagnosis comparing BactecTMMGITTM960 system (MGIT) to the Löwestein–Jensen (LJ) culture in a health center and in a university hospital, in Rio de Janeiro City, Brazil. Methods: Patient's mean costs were evaluated during the diagnosis process and cost-effectiveness based on mean time in days for the adoption of appropriate clinical anti

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Mittal, Vineeta, Manoj Kumar, and Ajay Kumar Singh. "TB LAMP assay, a beneficial tool for the diagnosis of Tubercular meningitis in resource-limited settings." Journal of Infection in Developing Countries 18, no. 03 (2024): 435–40. http://dx.doi.org/10.3855/jidc.18115.

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Introduction: Tubercular meningitis (TBM) is a serious public health problem in developing countries as it leads to significant mortality and residual neurological sequelae. The estimated mortality due to TBM in India is 1.5 per 100,000 population. In resource-limited settings, only the Ziehl-Neelsen (ZN) stain, which has very little sensitivity, is available. The World Health Organization recommended the Loop Mediated Isothermal Amplification (TB LAMP) assay for pulmonary tuberculosis only. We evaluated this test for tubercular meningitis as well. Methodology: In a cross-sectional study of 2-

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Ssengooba, Willy, David P. Kateete, Anne Wajja, et al. "An Early Morning Sputum Sample Is Necessary for the Diagnosis of Pulmonary Tuberculosis, Even with More Sensitive Techniques: A Prospective Cohort Study among Adolescent TB-Suspects in Uganda." Tuberculosis Research and Treatment 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/970203.

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The World Health Organization (WHO) recommends collection of two sputum samples for tuberculosis (TB) diagnosis, with at least one being an early morning (EM) using smear microscopy. It remains unclear whether this is necessary even when sputum culture is employed. Here, we determined the diagnostic yield from spot and the incremental yield from the EM sputum sample cultures among TB-suspected adolescents from rural Uganda. Sputum samples (both spot and early-morning) from 1862 adolescents were cultured by the Lowenstein-Jensen (LJ) and Mycobacterium Growth Indicator Tube (MGIT) methods. For s

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Sessolo, Abdulwahab, Emmanuel Musisi, Sylvia Kaswabuli, et al. "Diagnostic accuracy of Xpert MTB/RIF Ultra and culture assays to detect Mycobacterium Tuberculosis using OMNIgene-sputum processed stool among adult TB presumptive patients in Uganda." PLOS ONE 18, no. 4 (2023): e0284041. http://dx.doi.org/10.1371/journal.pone.0284041.

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Background Stool is a potential sample for diagnosing Mycobacterium tuberculosis (Mtb) in patients with difficulty in expectorating. However, high mycobacterial culture contamination rates and Xpert MTB/RIF Ultra test error rates on stool samples have limited its use. OMNIgene SPUTUM (OM-S) is a sample transport reagent with characteristics of sputum decontamination while maintaining viable Mtb. We evaluated the impact of OM-S on Mtb diagnostic yield from stool using smear microscopy, Xpert MTB/RIF Ultra, and culture among presumptive TB patients. Methods Paired stool and expectorated sputum s

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Qiu, Chaochao, Ning Pan, Yueying Zhou, et al. "Application Value of SAT-TB Combined with Acid-Fast Staining in the Diagnosis and Treatment of Pulmonary Tuberculosis." BioMed Research International 2020 (November 3, 2020): 1–5. http://dx.doi.org/10.1155/2020/3620425.

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Objectives. This study is aimed at evaluating the clinical application value of RNA simultaneous amplification and testing method for Mycobacterium tuberculosis (SAT-TB) combined with acid-fast staining in the diagnosis and treatment of pulmonary tuberculosis (PTB). Methods. This paper included 168 suspected and confirmed PTB sufferers admitted to The Sixth People’s Hospital of Wenzhou from December 2018 to December 2019, whose sputum was collected and tested using SAT-TB, smear acid-fast staining method, and the BACTEC MGIT 960 system. With the MGIT 960 culture test method as the gold standar

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SHAH, IRA, RASIKA BHAMRE, and NAMAN S. SHETTY. "Accuracy of Xpert^® MTB/RIF in diagnosing extrapulmonary tuberculosis in Indian children." National Medical Journal of India 35 (April 28, 2023): 334–37. http://dx.doi.org/10.25259/nmji_35_6_334.

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Background Diagnosing extrapulmonary tuberculosis (EPTB) can be challenging because of a variety of presentations. We assessed the accuracy of the Xpert MTB/RIF assay in diagnosing EPTB in children. Methods Of the 255 children diagnosed to have tuberculosis (TB) who underwent testing by the Xpert MTB/ RIF assay at the TB clinic from December 2014 to April 2017, 182 had EPTB and were included in the study. The diagnostic accuracy, specificity and sensitivity of the Xpert assay were calculated with Mycobacterium growth indicator tube (MGIT) as a reference standard. Results Lymph node TB was pres

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Rufai, Syed Beenish, Sarman Singh, Amit Singh, Parveen Kumar, Jitendra Singh, and Anand Vishal. "Performance of Xpert MTB/RIF on Ascitic Fluid Samples for Detection of Abdominal Tuberculosis." Journal of Laboratory Physicians 9, no. 01 (2017): 047–52. http://dx.doi.org/10.4103/0974-2727.187927.

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ABSTRACT Background: Diagnosis of abdominal tuberculosis (TB) from ascitic fluid samples using routinely available diagnostic methods is challenging due to its paucibacillary nature. Although performance of Xpert MTB/RIF assay has been evaluated extensively on pulmonary samples, its performance on extrapulmonary samples is still under evaluation. Objectives: The objective of this study was to find out the performance of Xpert MTB/RIF on ascitic fluid samples obtained from suspected cases of abdominal TB. Performance was compared with Mycobacterium growth indicator tube-960 (MGIT-960) culture a

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Muzanyi, Grace, Aber Peace, Bonny Wamuntu, Akol Joseph, and Joanita Nassali. "The threat of persistent bacteria and fungi contamination in tuberculosis sputum cultures." African Health Sciences 21, no. 2 (2021): 628–32. http://dx.doi.org/10.4314/ahs.v21i2.18.

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Background: Tuberculosis (TB) sputum culture contaminants make it difficult to obtain pure TB isolates.We aimed to study and identify persistent TB sputum culture contaminants post the standard laboratory pre-culture sample decontamination techniques. Methods: This was a longitudinal study of TB sputum culture contamination for a cohort of TB patients on standard treatment at: baseline, during TB treatment and post TB treatment. Sputum samples were decontaminated with 1.5%NaOH and neutralized using 6.8 Phosphate buffer solution.Sputum was then inoculated into MGIT (mycobactrial growth indicato

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de Almeida, Isabela Neves, Suely Conceição Alves da Silva, Haliton Alves de Oliveira Junior, et al. "The Activity-Based Cost of Drug-Susceptibility Test of Mycobacterium tuberculosis Through Kit SIRE Nitratase® Plastlabor." International Journal of Mycobacteriology 9, no. 1 (2020): 24–28. http://dx.doi.org/10.4103/ijmy.ijmy_8_20.

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Background: Drug-resistant tuberculosis (TB) is an ongoing health threat, and the greatest challenge to adequate control of TB in many countries lies in the lack of proper laboratory drug-susceptibility test. The aim of this study was to evaluate the activity-based costs (ABC) of Kit SIRE Nitratase® (Kit SIRE) and compare its values with the conventional drug-susceptibility test. Methods: The ABC was calculated for three different approaches: Kit SIRE (clinical samples and cultures), proportion methods in Lowenstein Jensen (PM-LJ), and the Bactec™ MGIT™ 960 system based on Mycobacterial Resear

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Kumar, Chanchal, Kamal Shrivastava, Anupriya Singh, Naresh Kumar Sharma, Jitender Yadav, and Mandira Varma-Basil. "The MPB64 immunochromatography assay: an analysis of doubtful results." Tropical Doctor 50, no. 4 (2020): 340–43. http://dx.doi.org/10.1177/0049475520934353.

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Culture remains the gold standard for tuberculosis (TB) diagnosis, and the mycobacteria growth indicator tube (MGIT), endorsed by the World Health Organization (WHO), is widely used. Further identification of a positive culture is done with the help of an immunochromatography assay, which often shows faint bands that are difficult to interpret. We analysed 125 BACTEC MGIT culture positive results, of which 11/16 (68.7%) of the doubtful assays, analysed by MGIT™ TBc Identification test (TBcId), were positive for Mycobacterium tuberculosis complex (MTBC), the remaining being non-tuberculous myco

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Paweninggalih, Resti Enggar, Ni Made Mertaniasih, Eko Budi Koendhori, and Soedarsono Soedarsono. "Time to detection of Mycobacterium tuberculosis using culture filtrate H37rv supplementation on MGIT 960 System." Bali Medical Journal 12, no. 1 (2023): 228–34. http://dx.doi.org/10.15562/bmj.v12i1.3833.

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Background: The fundamental priority program for controlling Tuberculosis (TB) is accurate and rapid diagnosis. Variable Mycobacterium tuberculosis (MTB) phenotypes were discovered in sputum samples from pulmonary TB (PTB) patients. Active replicating bacteria and differentially culturable tubercle bacteria (DCTB) are present in the sputum. Differentially culturable tubercle bacilli did not grow on the standard medium. Culture filtrate (CF) H37Rv supplementation containing resuscitation-promoting factors (Rpfs) has the potential to increase sensitivity and reduce time to detection (TTD) on cul

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Thuansuwan, Waraporn, Charoen Chuchottaworn, Chie Nakajima, Yasuhiko Suzuki, and Nuntaree Chaichanawongsaroj. "Biphasic Medium Using Nicotinamide for Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis." Antibiotics 13, no. 6 (2024): 563. http://dx.doi.org/10.3390/antibiotics13060563.

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Reliable drug susceptibility testing of pyrazinamide (PZA) is technically difficult, since PZA activity is pH sensitive. The aim of this study was to evaluate a biphasic medium assay (BMA) for the reliable detection of PZA resistance in Mycobacterium tuberculosis (MTB) using nicotinamide (NIC) as a surrogate for PZA and identifying the appropriate cut-off value for the assay. The PZA susceptibility of 122 multidrug-resistant tuberculosis (MDR-TB) isolates and 39 drug-susceptible tuberculosis (DS-TB) isolates was examined using the BMA with NIC at four different concentrations (250, 500, 1000,

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Chin, Kai Ling. "Molecular Characterization of Mycobacterium species Isolates from Patients with Pulmonary Tuberculosis in Sabah, Malaysia." Medicine & Health 17, no. 1 (2022): 198–210. http://dx.doi.org/10.17576/mh.2022.1701.15.

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Tuberculosis (TB) is one of the deadliest diseases worldwide, caused by members of Mycobacterium tuberculosis complex (MTBC), commonly by Mycobacterium tuberculosis (Mtb) and Mycobacterium bovis. In Malaysia, Sabah is one of the states of public health concern with the highest TB cases. Clinical presentations of TB and non-tuberculous mycobacteria (NTM) lung disease are similar, and mycobacteria appear to be identical under standard diagnosis with sputum smear microscopy, causing difficulty to diagnose TB. Identification of Mycobacterium species is essential for effective management of mycobac

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Domotenko, L. V., T. P. Morozova, I. G. Shemyakin, and A. P. Shepelin. "EXPERIENCE OF USING TB TEST KIT FOR THE RAPID DRUG SUSCEPTIBILITY TESTING OF M. TUBERCULOSIS." Russian Clinical Laboratory Diagnostics 65, no. 2 (2020): 122–30. http://dx.doi.org/10.18821/0869-2084-2020-65-2-122-130.

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The results of the comparative testing of the susceptibility of M. tuberculosis clinical strains to isoniazid, streptomycin, rifampicin and ethambutol using the TB test kit, developed in SCRAMB, (Obolensk) and the absolute concentrations method; the TB test kit and the BACTEC MGIT 960 automated system are presented in the study. A total of 629 and 220 strains, respectively, were tested. A high degree of agreement of the results was shown: 89.1-98.6% for isoniazid, 96.2-98.0% for rifampicin, 91.5-98.2% for streptomycin and 89.1-95.9% for ethambutol. The smallest number of discrepancies in the r

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Wahyuningrum, Retno, Ritmaleni Ritmaleni, Tatang Irianti, Subagus Wahyuono, and Takushi Kaneko. "ANTITUBERCULOSIS ACTIVITY OF EXTRACT AND FRACTIONS OF TINOSPORA CRISPA AGAINST MYCOBACTERIUM TUBERCULOSIS H37RV USING MYCOBACTERIA GROWTH INDICATOR TUBE AND AGAR PROPORTION METHOD." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (2018): 132. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.22587.

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Objective: The increasing incidence of multidrug-resistant tuberculosis (TB) has created a need to discover a new anti-TB drug candidates. The aim of this study was to screen extract and fractions of Tinospora crispa for activity against Mycobacterium tuberculosis H37Rv.Methods: The dried and pulverized T. crispa stem was extracted by maceration method using ethanol (96%). The anti-TB activity was carried out using mycobacteria growth indicator tube (MGIT) system and agar proportion method with Lowenstein–Jensen (LJ) medium.Result: The result of this study showed that ethanolic extract and fra

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Umpeleva, T. V., E. A. Mazurina, D. V. Vakhrusheva, and N. I. Eremeeva. "Comparison of Different Methods for Drug Susceptibility Testing of Mycobacterium tuberculosis to Rifampicin." Tuberculosis and Lung Diseases 100, no. 1 (2022): 41–48. http://dx.doi.org/10.21292/2075-1230-2022-100-1-41-48.

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The objective: to compare results of drug susceptibility testing to rifampicin by molecular genetic methods and phenotypic tests of Mycobacterium tuberculosis isolates obtained from clinical specimens of tuberculosis patients.Subjects and Methods. 915 samples of M. tuberculosis DNA and 426 cultures were used in this study. Genotypic tests (TB-TEST (BIOCIP-IMB, Russia), GenoType MTBDRplusV2) and phenotypic technologies (absolute concentration method, Bactec MGIT 960 system, Sensititre Myco TB kit) were used.Results. A high percentage (98.7%; CI 97.7-99.7%) of confirmation of the results of the

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Pedro, Heloisa da Silveira Paro, Andrea Gobetti Vieira Coelho, Susilene Maria Tonelli Nardi, et al. "Desempenho da cultura líquida MGIT após implementação em uma rede de laboratórios públicos do estado de São Paulo." Revista do Instituto Adolfo Lutz 76 (January 1, 2017): 1–9. http://dx.doi.org/10.53393/rial.2017.v76.33542.

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A OMS, em 2007, recomendou a implementação da cultura líquida para o diagnóstico da tuberculose (TB) e teste de sensibilidade para países de baixa e média renda. Neste estudo foi avaliado o desempenho da cultura líquida MGIT em condição de rotina após dois anos de implantação em uma rede de laboratórios públicos. Foi efetuada análise retrospectiva de dados da cultura líquida, realizadas em dez laboratórios regionais do Instituto Adolfo Lutz, de janeiro a março de 2010. Foram incluídas amostras submetidas a baciloscopia, cultura líquida MGIT automatizada ou manual e identificação presuntiva do

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Rambi, Elne Vieke, Dyan R. Sukandar, Linda Augustien Makalew, Yohanis Tomastola, and Ketrina Konoralma. "Multi drugs resistance to Diabetes Mellitus patients with tuberculosis in Manado City." Jurnal Teknologi Laboratorium 10, no. 1 (2021): 40–45. http://dx.doi.org/10.29238/teknolabjournal.v10i1.286.

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Diabetes mellitus (DM) with pulmonary tuberculosis (TB) is an infectious disease if not educated regularly, there will be a high risk of drug resistance and even some anti-tuberculosis drugs. This study aims to identify anti-tuberculosis drug resistance in DM patients with TB in Manado City. The population in the study types 2 DM patients as amount 80 patients. Based on TCM/GenExpert examination from 47 respondents, there were 17 respondents positive multi drugs resistance rifampicin (RR). Sampling taking based on inclusion criteria, i.e., have had type DM for five years, had suffered TB MDR R

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Lugonzo, George O., Ezekiel M. Njeru, William Songock, Albert A. Okumu, and Eric M. Ndombi. "Epidemiology of multi-drug resistant Tuberculosis in the western region of Kenya." AIMS Microbiology 10, no. 2 (2024): 273–87. http://dx.doi.org/10.3934/microbiol.2024014.

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<abstract> <p>Multidrug-resistant tuberculosis (TB) (MDR-TB), or TB that is simultaneously resistant to both isoniazid (INH) and rifampicin (RIF), is a barrier to successful TB control and treatment. Stratified data on MDR-TB, particularly in the high-burden western Kenya region, remain unknown. This data is important to monitor the efficacy of TB control and treatment efforts. Herein, we determined the molecular epidemiology of drug-resistant TB and associated risk factors in western Kenya. This was a non-experimental, population-based, cross-sectional study conducted between Janu

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Poddar, Chandan Kumar, Narmata Kumari, Rakesh Kumar, Shivendra Kumar Shahi, Naresh Kumar, and Shailesh Kumar. "Estimation of genotype MTBDRPLUS line probe assay in detection of rifampicin and isoniazid resistance in comparison to liquid culture (BACTEC-960) drug susceptibility testing in a tertiary care hospital from Eastern India." Biomedicine 41, no. 2 (2021): 472–76. http://dx.doi.org/10.51248/.v41i2.1060.

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Introduction and Aim: India has the uppermost trouble of Multidrug resistant tuberculosis (MDR-TB) is a major challenge controlling resistance, reducing transmission and improving handling outcomes in MDR-TB patients is dependent on susceptibility testing. Isoniazid (INH) and rifampicin (Rif) are the key first-line antituberculosis drugs, and resistance to these drugs i.e., MDR-TB, is likely to result in treatment failure and poor clinical outcomes. The present study was done to compare the performance of line probe assay test (GenoType® MTBDRplus) with liquid culture (MGIT 960) system for the

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Kalawadia, Dhruv, Darshini Gandhi, Tsering Y. Dirkhipa, et al. "Effect of delamanid on interim outcomes of bacteriological conversion amongst pediatric drug resistant tuberculosis cases in India." Lung India 41, no. 1 (2024): 35–39. http://dx.doi.org/10.4103/lungindia.lungindia_72_23.

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Aim: To determine the bacteriological conversion rate after 6 months of Delamanid (DLM) based treatment in children with drug-resistant tuberculosis (DR-TB) and determine factors associated with bacteriological conversion. Methods: This is a descriptive retrospective study done in children between the age of 6-17 years with DR-TB who received DLM-based therapy from October 2018 to May 2021. The drug resistance pattern of TB was detected using Xpert RIF/MTB and phenotypic drug sensitivity testing (DST) on TB-MGIT culture reports. Follow-up sputum TB MGIT culture was carried out monthly after DL

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Mapamba, Daniel Adon, Elingarami Sauli, Julieth Lalashowi, et al. "Performance of Tuberculosis Molecular Bacterial Load Assay Compared to Alere TB-LAM in Urine of Pulmonary Tuberculosis Patients with HIV Co-Infections." International Journal of Molecular Sciences 24, no. 4 (2023): 3715. http://dx.doi.org/10.3390/ijms24043715.

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Alternative tools are needed to improve the detection of M. tuberculosis (M. tb) in HIV co-infections. We evaluated the utility of Tuberculosis Molecular Bacterial Load Assay (TB-MBLA) compared to lipoarabinomannan (LAM) to detect M. tb in urine. Sputum Xpert MTB/RIF-positive patients were consented to provide urine at baseline, weeks 2, 8, 16, and 24 of treatment for TB-MBLA, culture, and LAM. Results were compared with sputum cultures and microscopy. Initial M. tb. H37Rv spiking experiments were performed to validate the tests. A total of 63 urine samples from 47 patients were analyzed. The

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Barik, Braja Sundar, Shritam Das, Khusbu Singh, et al. "Diagnostic Accuracy of The TrueNat MTB/RIF Assay And Comparison With The Reference Standards To Detect Pulmonary Tuberculosis And Rifampicin Resistance in Sputum Samples From Patients Attending A Tertiary Care Hospital in Bhubaneswar, India." National Journal of Community Medicine 15, no. 03 (2024): 175–81. http://dx.doi.org/10.55489/njcm.150320243413.

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Background: A rapid and accurate diagnostic tool is necessary for correct diagnosis and treatment of TB. This study evaluated and compared the sensitivity, specificity and concordance of TrueNAT MTB/RIF assay with smear microscopy, Xpert MTB/RIF and MGIT culture. Methods: In all, 4500 patients (1500 each of patients with Diabetes, elderly and HIV-positive patients) attending the Chest and TB department of Capital Hospital, Bhubaneswar were screened. 392 sputum samples were collected from presumptive TB patients. Standard diagnostic procedures (Smear Microscopy, Xpert MTB/RIF, TrueNAT MTB tests

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R Lia Kusumawati, Mirzan Hasibuan, Nisrina Tari, Kyaw Ko Ko Htet, and Nyi Nyi Zayar. "Comparison of GeneXpert and line probe assay for the detection of Mycobacterium tuberculosis in direct sputum samples." Indonesian Journal of Biomedicine and Clinical Sciences 57, no. 1 (2025): 1–10. https://doi.org/10.22146/inajbcs.v57i1.16720.

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Tuberculosis (TB) remains a major global health issue, particularly in low-and- middle-income countries (LMICs) like Indonesia. Diagnostic methods for TB and multidrug-resistant TB (MDR-TB) such as Lowenstein-Jensen (LJ) solid media and Mycobacterium Growth Indicator Tube (MGIT), are time-consuming, causing delays in patient management. Rapid molecular diagnostics, like the GeneXpert MTB/RIF ultra assay and line probe assay (LPA), offer faster and more accurate detection of Mycobacterium tuberculosis and drug resistance. This study aimed to compare the efficacy of GeneXpert and LPA in detectin

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Murcia Aranguren, Martha Isabel, Clara Viviana Mape, Mario Alejandro Vega Marin, et al. "High prevalence of pulmonary tuberculosis in the indigenous population of Puerto Nariño, Colombian Amazonia." Revista de Salud Pública 27, no. 1 (2025): 1–8. https://doi.org/10.15446/rsap.v27n1.117145.

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Tuberculosis (tb) remains a significant public health challenge, disproportionately impacting vulnerable groups, particularly indigenous populations. Objetive To investigate the epidemiological behavior of tb among the indigenous communities in Puerto Nariño, Amazonas. Materials and Methods Descriptive cross-sectional study across 23 indigenous communities, employing an active case-finding approach through house-to-house medical consultations. Respiratory symptomatic (rs) individuals, defined as those with a cough of any duration, were identified and assessed. Diagnostic evaluations included s

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Handayani, Diah, Budi Haryanto, Galoeh Adyasiwi, et al. "Diagnostic Accuracy and Clinical Utility of InaTB-Rif, Locally Developed Molecular Test for Tuberculosis, in Comparison with Xpert MTB/RIF in Indonesia." Jurnal Respirologi Indonesia 45, no. 2 (2025): 136–43. https://doi.org/10.36497/jri.v45i2.907.

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Background: Tuberculosis (TB) remains a significant public health issue in Indonesia. Early and accurate diagnosis and drug susceptibility testing are essential for TB management. This study compared the diagnostic accuracy of the locally developed InaTB-Rif molecular test and Xpert MTB/RIF, using Mycobacterium Growth Indicator Tube (MGIT) culture as the reference standard. Methods: A cross-sectional study was conducted at Persahabatan Hospital, Jakarta, from February to August 2023. Presumptive pulmonary TB patients were recruited and tested using Xpert MTB/RIF, InaTB-Rif, and MGIT culture. T

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Heysell, Scott K., Suporn Pholwat, Stellah G. Mpagama, et al. "Sensititre MycoTB Plate Compared to Bactec MGIT 960 for First- and Second-Line Antituberculosis Drug Susceptibility Testing in Tanzania: a Call To Operationalize MICs." Antimicrobial Agents and Chemotherapy 59, no. 11 (2015): 7104–8. http://dx.doi.org/10.1128/aac.01117-15.

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ABSTRACTMIC testing forMycobacterium tuberculosisis now commercially available. Drug susceptibility testing by the MycoTB MIC plate has not been directly compared to that by the Bactec MGIT 960. We describe a case of extensively drug-resistant tuberculosis (XDR-TB) in Tanzania where initial MIC testing may have prevented acquired resistance. From testing on archived isolates, the accuracy with the MycoTB plate was >90% for important first- and second-line drugs compared to that with the MGIT 960, and clinically useful quantitative interpretation was also provided.

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Oliveira, Gabriel Da Silva, Glaura Regina de Castro e. Caldo Lima, Joaquim Xavier da Silva, Janeth De Oliveira Silva Naves, and Carlos Maximiliano do Rêgo Monteiro Filho. "Identificação laboratorial de micobactérias em amostras respiratórias de pacientes com suspeita de tuberculose pulmonar no Laboratório Central de Saúde Pública do Distrito Federal (LACEN-DF)Laboratory identification of mycobacteria from respiratory samples of patients with suspected pulmonary tuberculosis in samples isolated at the Central Laboratory of Public Health of the Federal District (LACEN-DF)doi:10.12662/2317-3076jhbs.v4i3.712.p187-192.2016." Journal of Health & Biological Sciences 4, no. 3 (2016): 187. http://dx.doi.org/10.12662/2317-3076jhbs.v4i3.712.p187-192.2016.

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Introdução: O diagnóstico rápido e preciso da tuberculose (TB) e o início precoce do tratamento são fatores de grande importância para reduzir e minimizar o risco de contágio pelo Mycobacterium tuberculosis. Nesse contexto, as principais metodologias empregadas no Brasil para o diagnóstico da TB são os testes de baciloscopia e de cultura. Objetivo: O presente estudo tem como objetivo descrever os resultados de três técnicas laboratoriais para o diagnóstico da TB pulmonar. Métodos: Foram analisados dados de baciloscopias e culturas de 10.418 prontuários de pacientes de ambos os sexos, diferente

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Champatiray, Jyotiranjan, and G. Dharmaraj Patra. "Diagnosis of paediatric tuberculosis by cartridge based nucleic acid amplification test and its effectiveness as compared to the other conventional diagnostic methods." International Journal of Contemporary Pediatrics 6, no. 3 (2019): 1204. http://dx.doi.org/10.18203/2349-3291.ijcp20192013.

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Background: Childhood TB constitutes 10-20% of all TB cases in high burden countries like India and accounting for 8-20% of TB related deaths. Diagnosis of TB in children is difficult. One test, CBNAAT which was recently endorsed by WHO has the potential to lead a revolution in diagnosis of active TB disease.Methods: A cross sectional study in SCB MCH and SVPPGIP, Cuttack in all the suspected TB patients admitted during the period from January 2016 to October 2017.Results: A total of 100 suspicious patients admitted to the Department of Pediatrics in SCB MCH and SVPPGIP during the study period

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Kania, Katarzyna, Katarzyna Wójcik, Kamil Drożdż, and Karolina Klesiewicz. "Utility of Rapid Molecular Assays for Detecting Multidrug-Resistant Mycobacterium tuberculosis in Extrapulmonary Samples." Diagnostics 15, no. 9 (2025): 1113. https://doi.org/10.3390/diagnostics15091113.

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Background: Extrapulmonary tuberculosis (TB) presents significant diagnostic challenges, particularly in the context of multidrug-resistant (MDR) strains. This study assessed the utility of the WHO-recommended rapid molecular assays, originally validated for pulmonary TB, in diagnosing extrapulmonary TB and detecting the MDR Mycobacterium tuberculosis complex (MTBC). Materials and Methods: A total of 6274 clinical samples, including 4891 pulmonary and 1383 extrapulmonary samples, were analyzed between 2019 and 2022 using the BD MAX™ MDR-TB assay (BD MAX), the Xpert® MTB/RIF assay (Xpert MTB/RI

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Yana, Dewi, Ni Made Mertaniasih, Eko Budi Koendhori, and Rosy Setiawati. "The radiologic findings, positivity rate of culture method examinations, correlation with the type of lower respiratory secretion of adult pulmonary Tuberculosis (TB) patients." Bali Medical Journal 12, no. 1 (2023): 1152–57. http://dx.doi.org/10.15562/bmj.v12i1.4090.

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Background: There are active and latent tuberculosis types, a global public health concern. Test confirmation is required to distinguish between active tuberculosis and nontuberculous mycobacterial infection. This study aims to evaluate the relationship between the type of lower airway secretion specimen, Mycobacterium tuberculosis positivity rate of MGIT-LJ, as well as the relationship between the Mycobacterium tuberculosis positivity rate in MGIT-LJ and radiological findings. Methods: This study is cross-sectional with a prospective design. The sample is the result of the examination of the

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Dwivedi, Dharm Prakash, Amrita Shukla, Vinod Raveendran, and Muthuraj Muthaiah. "Prevalence of primary INH and Rifampicin resistance among treatment Naïve tuberculosis cases in tertiary care teaching hospital in Puducherry: A prospective cross-sectional study." IP Indian Journal of Immunology and Respiratory Medicine 7, no. 4 (2023): 154–60. http://dx.doi.org/10.18231/j.ijirm.2022.035.

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India contributes to approximately one-third of total global tuberculosis (TB) and one-fourth of all Multi-Drug Resistant TB (MDR-TB) burden respectively. The First National drug resistance survey (2014-16) showed MDRTB rates of 6.19% overall and 2.14% in newly diagnosed TB cases. With the above problem of primary drug resistance among newly diagnosed tuberculosis cases, the present study was planned to find the prevalence of Isoniazid (INH) and Rifampicin resistance in the treatment naïve new tuberculosis cases.: Study design: Prospective, cross-sectional.: Treatment naive newly diagnosed pul

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Widaningsih, Yuyun, Ismawati Amin, Nurhayana Sennang, Uleng Bahrun, and Mansyur Arif. "MYCOBACTERIUM TUBERCULOSIS DAN PCR." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 18, no. 3 (2016): 179. http://dx.doi.org/10.24293/ijcpml.v18i3.756.

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TB’s coinfection in HIV and AIDS is on the increase together with the high mortality rate. The disseminated TB infection (in blood) of HIV and AIDS patients in Africa (2005) is about 10−25%. The aim of this study was to identify M.tb disseminated infection in HIV and AIDS patients. In this study was done in six HIV and AIDS patients suffering from suspected TB co infection. The sputum was tested using Fast Acid Bacilli and culture (using LJ and MGIT media) and DST. The identification of M.tb in blood used PCR with IS6110 primer (123 bp). The study was done at Dr. Wahidin Sudirohusodo Hospital,

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Azam, Khalide, Nureisha Cadir, Carla Madeira, Stephen H. Gillespie, and Wilber Sabiiti. "OMNIgene.SPUTUM suppresses contaminants while maintainingMycobacterium tuberculosisviability and obviates cold-chain transport." ERJ Open Research 4, no. 1 (2018): 00074–2017. http://dx.doi.org/10.1183/23120541.00074-2017.

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Tuberculosis (TB) diagnostics are centralised, requiring long-distance transportation of specimens in most resource-limited settings. We evaluated the ability of OMNIgene.SPUTUM (OM-S) to obviate cold-chain transport of TB specimens.A two-arm (same-day and after 5 days sample processing) study was conducted to assess contamination rates andMycobacterium tuberculosisviability in OM-S-treated samples against the standard decontamination procedure (SDP) in Mozambique, using Lowenstein Jensen (LJ) and mycobacterial growth indicator tube (MGIT) culture and molecular bacterial load assay.270 specime

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Puyén, Zully M., David Santos-Lázaro, Aiko N. Vigo, et al. "Whole Genome Sequencing of Mycobacterium tuberculosis under routine conditions in a high-burden area of multidrug-resistant tuberculosis in Peru." PLOS ONE 19, no. 6 (2024): e0304130. http://dx.doi.org/10.1371/journal.pone.0304130.

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Whole Genome Sequencing (WGS) is a promising tool in the global fight against tuberculosis (TB). The aim of this study was to evaluate the use of WGS in routine conditions for detection of drug resistance markers and transmission clusters in a multidrug-resistant TB hot-spot area in Peru. For this, 140 drug-resistant Mycobacterium tuberculosis strains from Lima and Callao were prospectively selected and processed through routine (GenoType MTBDRsl and BACTEC MGIT) and WGS workflows, simultaneously. Resistance was determined in accordance with the World Health Organization mutation catalogue. Ag

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Jajou, Rana, Tridia van der Laan, Rina de Zwaan, et al. "WGS more accurately predicts susceptibility of Mycobacterium tuberculosis to first-line drugs than phenotypic testing." Journal of Antimicrobial Chemotherapy 74, no. 9 (2019): 2605–16. http://dx.doi.org/10.1093/jac/dkz215.

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Abstract Background Drug-susceptibility testing (DST) of Mycobacterium tuberculosis complex (MTBC) isolates by the Mycobacteria Growth Indicator Tube (MGIT) approach is the most widely applied reference standard. However, the use of WGS is increasing in many developed countries to detect resistance and predict susceptibility. We investigated the reliability of WGS in predicting drug susceptibility, and analysed the discrepancies between WGS and MGIT against the first-line drugs rifampicin, isoniazid, ethambutol and pyrazinamide. Methods DST by MGIT and WGS was performed on MTBC isolates receiv

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Firoz, Shehraz, and Sonia Bhatt. "Diagnostic value of polymerase chain reaction targeting insertion sequence IS1081 for the diagnosis of pediatric tuberculosis." International Journal of Contemporary Pediatrics 7, no. 4 (2020): 905. http://dx.doi.org/10.18203/2349-3291.ijcp20201152.

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Background: Aim of this study was to evaluate the efficacy of PCR targeting IS1081in diagnosis of pediatric tuberculosis and compare the results with MGIT culture.Methods: This prospective study was conducted in the department of pediatrics, S.N. medical college, Agra. 100 subjects (28 pulmonary 72 extra pulmonary) were registered in study. The specimens obtained from these cases were subjected to Ziehl–Neelsen staining (ZN), MGIT 960 TB culture and PCR targeting insertion sequence IS1081. Sensitivity, specificity, PPV and NPV of PCR were calculated in pulmonary and extra pulmonary specimens.

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Krishnan, Manju Y., Elizabeth J. B. Manning, and Michael T. Collins. "Stability of antibacterial agents in MGIT™ Para TB Medium." International Journal of Antimicrobial Agents 33, no. 2 (2009): 186–87. http://dx.doi.org/10.1016/j.ijantimicag.2008.07.027.

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Borodulina, E. A., A. T. Inkova, B. E. Borodulin, and L. V. Povalyaeva. "WAYS TO OPTIMIZE DETECTION OF TUBERCULOSIS IN A PULMONOLOGY UNIT." Tuberculosis and Lung Diseases 96, no. 5 (2018): 22–26. http://dx.doi.org/10.21292/2075-1230-2018-96-5-22-26.

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The objective: to optimize detection of tuberculosis in a pulmonology unit.Subjects and methods.In a pulmonology unit, patients suspected of having tuberculosis had a minimum number of diagnostic tests: a skin test with tuberculous recombinant allergen, three consecutive Ziel-Nelson microscopies of sputum and fluids of bronchoalveolar lavage, and in the laboratory of TB services they performed GeneXpert MTB/RIF, Bactec MGIT. Results of the diagnostics were analyzed in 70 patients with etiologic confirmation of diagnosis.Results.A targeted inquiry and taking the patient's history were informati

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Wang, Linwei, Sohaib H. Mohammad, Boonchai Chaiyasirinroje, et al. "Evaluating the Auto-MODS Assay, a Novel Tool for Tuberculosis Diagnosis for Use in Resource-Limited Settings." Journal of Clinical Microbiology 53, no. 1 (2014): 172–78. http://dx.doi.org/10.1128/jcm.01946-14.

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There is an urgent need for simple, rapid, and affordable diagnostic tests for tuberculosis (TB) to combat the great burden of the disease in developing countries. The microscopic observation drug susceptibility assay (MODS) is a promising tool to fill this need, but it is not widely used due to concerns regarding its biosafety and efficiency. This study evaluated the automated MODS (Auto-MODS), which operates on principles similar to those of MODS but with several key modifications, making it an appealing alternative to MODS in resource-limited settings. In the operational setting of Chiang R

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Kadhim, Afraa Ali, Mohammed Faraj AL-Marjan, Kadhim Ali Kadhim, and Ahmed Asmar Manki. "Isolation of Mycobacterium tuberculosis and testing their susceptibility to antimicrobial agents by using Bactec 960." Al Mustansiriyah Journal of Pharmaceutical Sciences 13, no. 1 (2013): 175–81. http://dx.doi.org/10.32947/ajps.v13i1.213.

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This study was done from 3/7/2011 to 1/1/2012 , different clinical samples were collected from (1235) patients that coming to the Specialized center for chest and respiratory diseases / Baghdad to investigate Mycobacterium tuberculosis and study their resistant to first and second line antimicrobial agents by using Bactec 960.The results obtained from direct smear examination with Ziehl – Neelsen stain in (294) patients that indicated these patients are Infected with tuberculosis . These samples has been cultured on solid medium Lowenstein Jensen media (L.J.) and liquid medium ( middle brook 7

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Shetye, Shamma, P. Chheda, A. Lad, and S. Matkar. "PERFORMANCE OF XPERT MTB/RIF ASSAY FOR DETECTION OF M.TB IN PULMONARY AND EXTRA-PULMONARY SAMPLES IN INDIAN PATIENTS." SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS 14, no. 1 (2017): 7–13. http://dx.doi.org/10.3126/saarctb.v14i1.17720.

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Introduction: Conventional methods like Ziehl-Neelsen (ZN) staining and liquid culture have been the mainstay for diagnosis of Tuberculosis (TB). The gold standard Liquid Culture method has a longer turnaround time. In the wake of the TB catastrophe, newer rapid and easily accessible methods of detection are the need of the hour. A molecular method like the Xpert MTB/RIF assay has revolutionized the early and rapid diagnosis of TB. Objective of the current study was to assess the performance and utility of Xpert MTB/RIF assay for the diagnosis of M. tuberculosis in pulmonary and extra-pulmonar

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