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Northcott, Christopher Barry. "The development of MI5 1909-1918." Thesis, University of Bedfordshire, 2005. http://hdl.handle.net/10547/346882.
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The 1909-1918 era can be regarded as the formative years of MI5, as it developed from a small counter-espionage bureau into an established security intelligence agency. MI5 had two main roles during this period; counter-espionage, and advising the War Office on how to deal with the police and the civilian population, particularly aliens. Most of the existing literature tends to focus on the development of MI5 as a whole and pays little attention to the six individual branches that constituted MI5 by the armistice. Recently released MI5 documents in The National Archives (rnA) make it possible to examine MI5 at the micro level and set out the intimate workings of its six branches. The study examines the evolution of MI5 from its formation in October 1909 to the end of the First World War in November 1918, paying particular attention to three questions. First, what did a map of the structure of the MI5 organisation look like and "how" did it develop during these years? Secondly, "why" did it develop as it did? Thirdly, "how effective" was MI5 throughout this period? MI5 began as a one-man affair in 1909, tasked with the limited remit of ascertaining the extent of Gemlan espionage in Britain and an uncertain future. By the armistice MI5's role had expanded considerably and it had begun to develop into an established security intelligence agency, with 844 personnel spread over six branches covering the investigation of espionage, prevention, records, ports and travellers, overseas, and alien workers. This study suggests that the main driver of these developments, if one key factor can be singled out, was the changing perception of the nature of the threat posed by German espionage. However, because some within official circles equated all forms of opposition to Government policy with support for Germany, increasing attention also began to be paid to the possibility that industrial umest, pacifists and others who opposed the Government might actually be being directed by a German "hidden hand". From 1917 onwards MI5's development was driven by a conviction that it had defeated German espionage, such that Germany had switched its efforts to promoting Bolshevism and other forms of umest in order to undermine British society. However, MI5's activities were restricted to investigating if there was really any enemy influence behind such things, while Special Branch was to focus on labour unrest generally. This study makes an original and useful contribution to knowledge in three noteworthy respects. First, it sets out probably the most detailed description of MI5's organisational structure available. Secondly, it poses the stimulating question of "how to measure" the effectiveness of a counter-espionage agency? Thirdly, it suggests that, contrary to claims that Vemon Kell was an "empire builder" who wanted a greater role in labour intelligence, Kell felt it appropriate that MI5's activities should be restricted to the investigation of cases of peace propaganda and sedition that arose from enemy activities and did not actually want MI5 to assume a broader role in labour intelligence at that time.
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Мовчан, Світлана Борисівна, and Людмила Миколаївна Бармашина. "Особливості молодіжного центру «Rivas Vaciamadrid» Mi5 Arquitectos." Thesis, Національній авіаційний університет, 2019. https://er.nau.edu.ua/handle/NAU/52731.
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У статті був виконаний аналіз та розбір молодіжного науково-інноваційного центру, характерні принципи та особливості проектування молодіжних центрів, розроблених архітекторами Mi5 Arquitectos; створення будівлі, як взаємопов’язаних між собою комплексів для життя.
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Мовчан, Світлана Борисівна, and Людмила Миколаївна Бармашина. "Особливості молодіжного центру «Rivas Vaciamadrid» Mi5 Arquitectos." Thesis, Національній авіаційний університет, 2019. http://er.nau.edu.ua/handle/NAU/41150.
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У статті був виконаний аналіз та розбір молодіжного науково-інноваційного центру, характерні принципи та особливості проектування молодіжних центрів, розроблених архітекторами Mi5 Arquitectos; створення будівлі, як взаємопов’язаних між собою комплексів для життя.
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Wright, Simon Robert. "British policing : future roles and responsibilities." Thesis, Manchester Metropolitan University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311208.
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Quinlan, Kevin Patrick. "Human intelligence tradecraft and MI5 operations in Britain, 1919-1940." Thesis, University of Cambridge, 2008. https://www.repository.cam.ac.uk/handle/1810/252117.
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Rindberg, Jonas. "Kartdataimport för fälttillämpning." Thesis, Högskolan Dalarna, Datateknik, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:du-2404.
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I dagsläget kan WM-datas Fältmodul i deras MoveITS-system inte hantera kartdata i andra format än Shape. Fältmodulen är en TabletPC som kör operativsystemet Windows XP. Den kan användas för att redigera viss geografisk information som exempelvis skyltpositioner. Fältmodulen används av Stockholms Tekniska kontor för inventering av skyltstolpar.Stockholms Tekniska kontor ska börja leverera sina kartor i GML (Geography Markup Language). Men eftersom WM-datas Fältmodul inte klarar av det formatet skulle det här examensarbetet gå ut på att ta fram komponenter för hantering av det. Då det under examensarbetets gång har varit svårt att få tag i information runt GML har istället en större fokus blivit lagd på MIF (MapInfo Interchange Format). Eftersom det finns andra kommuner som använder MIF finns det intresse från WM-data att det tas fram komponenter även för detta format.Ett stort antal klasser har utvecklats för hantering av MIF-filer. Dessa klasser är helt utvecklade i C# och har gjorts under examensarbetets gång utifrån de specifikationer som finns för formatet från företaget MapInfo. För GML har det tagits fram information som kan ligga till grund för utveckling av komponenter för hantering av det formatet.
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Bohman, Jennie. "Text till film : En studie av adaptionsproblematiken och hur sagan förvandlas till en visuell verklighet." Thesis, Karlstad University, Faculty of Arts and Education, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-2254.
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Jag söker svaret på frågan om texttrogenhet vid adaption från text till film är önskvärt. Ska man sträva efter att återskapa texten i ett nytt medium, eller ska filmen ses som en ny skapelse?
Det har idag blivit en naturlig reaktion att genast utnämna filmatiseringen till förlorare samtidigt som det länge pågått debatter om huruvida litteraturen kommer att försvinna i skuggan av filmversionerna. Många väljer idag att se filmen istället för att läsa den litterära förlagan.
Efter kortare genomgång av forskning och en studie av två välkända barnböcker har jag fått en djupare förståelse för hur de båda medierna står i förbund med varandra. Text och film är två skilda medium som försöker mötas. Medan text är ett enkelspårigt medium så kan filmen använda sig av många effekter för att visa sin publik vad den vill ha.
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Dahlgren, Fredrik, and Nyström Elvira Nyström Elvira. "Hur kan högläsning bidra tillläroplanens värdegrundsarbete? -en fallstudie utifrån Mio, min Mio." Thesis, Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-85745.
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Studien behandlar Astrid Lindgrens bok Mio, min Mio från år 1954. Det är en känd barnboksom har blivit läst av många barn genom åren. Studien utgår från två olika delar.De olika delarna behandlar två olika saker. Först presenteras en analys av vetenskapliglitteratur ur perspektivet högläsning som didaktiskt val och värdegrundsuppdraget iLäroplanen (LGR11). Vi diskuterar kring centrala verktyg som praktiskt kan bidra ihögläsning.Den andra delen är en fallstudie där vi ska pröva våra teorier från uppsatsens inledande del iett antal olika frågeställningar på det skönlitterära verket Mio, min Mio av Astrid Lindgren.De metoder som används för att fullfölja studiens frågeställningar är en fallstudie, där sökningav litteratur av olika böcker och verk används för att få fram de svar som eftersöks. Studieninnehåller också egna tankar, reflektioner och analyser vad gäller högläsning och bokensinnehåll. De resultat som framgår i studien är att högläsning har många möjligheter ochutmaningar men framför allt att högläsningen har betydelse för barnens språkliga utveckling.Studien visar också ett resultat av att boken är möjlig att koppla ihop med läroplanensvärdegrundsuppdrag och bidra till dess fullgörande.
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Hellström, Lisa. ""Den du så länge har sökt är på väg" : Messianska föreställningar i Astrid Lindgrens text Mio, min Mio utifrån Werblowskys typologi." Thesis, Högskolan Dalarna, Religionsvetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:du-29338.
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Min uppgift och syfte med denna uppsats har varit att undersöka om Zwi RJ Werblowskys teori om messianism kan appliceras på texten Mio, min Mio. Den andra uppgiften har varit att pröva om hypotesen att texten Mio, min Mio av författarinnan Astrid Lindgren innehåller messianska föreställningar stämmer. Till min hjälp tog jag religionshistorikern Zwi RJ Werblowskys artikel: "Messiah and Messianic movement". Utifrån hans text kunde åtta typologiseringar utkristalliseras. Dessa var; tiden, messiasfiguren, ledaren, mytologiseringen och de dualistiska delarna visionärt-rationellt, aktiv-passiv, konservativa regler-revolutionära regler och inklusive-exklusive. Jag använde mig av närläsning som metod. I arbetet presenteras både slutsatser och en diskussion utifrån tidigare forskning kring dessa. Det har varit intressant att blanda olika discipliner i denna uppsats. Jag har använt mig av en religionshistorisk modell på en skönlitterär text, vilket kan ses som fruktbart och utvecklande för framtida forskning.
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Min, Aleksey. "Limit theorems for statistical functionals with applications to dimension estimation." Doctoral thesis, [S.l.] : [s.n.], 2004. http://webdoc.sub.gwdg.de/diss/2004/min/min.pdf.
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Huang, Min-Feng. "Resilience in chronic disease : the relationships among risk factors, protective factors, adaptive outcomes, and the level of resilience in adults with diabetes." Thesis, Queensland University of Technology, 2009. https://eprints.qut.edu.au/30313/1/Min-Feng_Huang_Thesis.pdf.
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Background: There are innumerable diabetes studies that have investigated associations between risk factors, protective factors, and health outcomes; however, these individual predictors are part of a complex network of interacting forces. Moreover, there is little awareness about resilience or its importance in chronic disease in adulthood, especially diabetes. Thus, this is the first study to: (1) extensively investigate the relationships among a host of predictors and multiple adaptive outcomes; and (2) conceptualise a resilience model among people with diabetes. Methods: This cross-sectional study was divided into two research studies. Study One was to translate two diabetes-specific instruments (Problem Areas In Diabetes, PAID; Diabetes Coping Measure, DCM) into a Chinese version and to examine their psychometric properties for use in Study Two in a convenience sample of 205 outpatients with type 2 diabetes. In Study Two, an integrated theoretical model is developed and evaluated using the structural equation modelling (SEM) technique. A self-administered questionnaire was completed by 345 people with type 2 diabetes from the endocrine outpatient departments of three hospitals in Taiwan. Results: Confirmatory factor analyses confirmed a one-factor structure of the PAID-C which was similar to the original version of the PAID. Strong content validity of the PAID-C was demonstrated. The PAID-C was associated with HbA1c and diabetes self-care behaviours, confirming satisfactory criterion validity. There was a moderate relationship between the PAID-C and the Perceived Stress Scale, supporting satisfactory convergent validity. The PAID-C also demonstrated satisfactory stability and high internal consistency. A four-factor structure and strong content validity of the DCM-C was confirmed. Criterion validity demonstrated that the DCM-C was significantly associated with HbA1c and diabetes self-care behaviours. There was a statistical correlation between the DCM-C and the Revised Ways of Coping Checklist, suggesting satisfactory convergent validity. Test-retest reliability demonstrated satisfactory stability of the DCM-C. The total scale of the DCM-C showed adequate internal consistency. Age, duration of diabetes, diabetes symptoms, diabetes distress, physical activity, coping strategies, and social support were the most consistent factors associated with adaptive outcomes in adults with diabetes. Resilience was positively associated with coping strategies, social support, health-related quality of life, and diabetes self-care behaviours. Results of the structural equation modelling revealed protective factors had a significant direct effect on adaptive outcomes; however, the construct of risk factors was not significantly related to adaptive outcomes. Moreover, resilience can moderate the relationships among protective factors and adaptive outcomes, but there were no interaction effects of risk factors and resilience on adaptive outcomes. Conclusion: This study contributes to an understanding of how risk factors and protective factors work together to influence adaptive outcomes in blood sugar control, health-related quality of life, and diabetes self-care behaviours. Additionally, resilience is a positive personality characteristic and may be importantly involved in the adjustment process among people living with type 2 diabetes.
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Wu, Min-Lin (Winnie). "The relationship between chronic disease self-efficacy and nutritional status, functional ability and quality of life in older adults at risk of hospital readmission." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/50925/1/Min-Lin_Wu_Thesis.pdf.
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Background and significance: Older adults with chronic diseases are at increasing risk of hospital admission and readmission. Approximately 75% of adults have at least one chronic condition, and the odds of developing a chronic condition increases with age. Chronic diseases consume about 70% of the total Australian health expenditure, and about 59% of hospital events for chronic conditions are potentially preventable. These figures have brought to light the importance of the management of chronic disease among the growing older population. Many studies have endeavoured to develop effective chronic disease management programs by applying social cognitive theory. However, limited studies have focused on chronic disease self-management in older adults at high risk of hospital readmission. Moreover, although the majority of studies have covered wide and valuable outcome measures, there is scant evidence on examining the fundamental health outcomes such as nutritional status, functional status and health-related quality of life.
Aim: The aim of this research was to test social cognitive theory in relation to self-efficacy in managing chronic disease and three health outcomes, namely nutritional status, functional status, and health-related quality of life, in older adults at high risk of hospital readmission.
Methods: A cross-sectional study design was employed for this research. Three studies were undertaken. Study One examined the nutritional status and validation of a nutritional screening tool; Study Two explored the relationships between participants. characteristics, self-efficacy beliefs, and health outcomes based on the study.s hypothesized model; Study Three tested a theoretical model based on social cognitive theory, which examines potential mechanisms of the mediation effects of social support and self-efficacy beliefs. One hundred and fifty-seven patients aged 65 years and older with a medical admission and at least one risk factor for readmission were recruited. Data were collected from medical records on demographics, medical history, and from self-report questionnaires. The nutrition data were collected by two registered nurses. For Study One, a contingency table and the kappa statistic was used to determine the validity of the Malnutrition Screening Tool. In Study Two, standard multiple regression, hierarchical multiple regression and logistic regression were undertaken to determine the significant influential predictors for the three health outcome measures. For Study Three, a structural equation modelling approach was taken to test the hypothesized self-efficacy model.
Results: The findings of Study One suggested that a high prevalence of malnutrition continues to be a concern in older adults as the prevalence of malnutrition was 20.6% according to the Subjective Global Assessment. Additionally, the findings confirmed that the Malnutrition Screening Tool is a valid nutritional screening tool for hospitalized older adults at risk of readmission when compared to the Subjective Global Assessment with high sensitivity (94%), and specificity (89%) and substantial agreement between these two methods (k = .74, p < .001; 95% CI .62-.86).
Analysis data for Study Two found that depressive symptoms and perceived social support were the two strongest influential factors for self-efficacy in managing chronic disease in a hierarchical multiple regression. Results of multivariable regression models suggested advancing age, depressive symptoms and less tangible support were three important predictors for malnutrition. In terms of functional status, a standard regression model found that social support was the strongest predictor for the Instrumental Activities of Daily Living, followed by self-efficacy in managing chronic disease. The results of standard multiple regression revealed that the number of hospital readmission risk factors adversely affected the physical component score, while depressive symptoms and self-efficacy beliefs were two significant predictors for the mental component score.
In Study Three, the results of the structural equation modelling found that self-efficacy partially mediated the effect of health characteristics and depression on health-related quality of life. The health characteristics had strong direct effects on functional status and body mass index. The results also indicated that social support partially mediated the relationship between health characteristics and functional status. With regard to the joint effects of social support and self-efficacy, social support fully mediated the effect of health characteristics on self-efficacy, and self-efficacy partially mediated the effect of social support on functional status and health-related quality of life. The results also demonstrated that the models fitted the data well with relative high variance explained by the models, implying the hypothesized constructs under discussion were highly relevant, and hence the application for social cognitive theory in this context was supported.
Conclusion: This thesis highlights the applicability of social cognitive theory on chronic disease self-management in older adults at risk of hospital readmission. Further studies are recommended to validate and continue to extend the development of social cognitive theory on chronic disease self-management in older adults to improve their nutritional and functional status, and health-related quality of life.
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Hahn, Peter. "MIR-Evaneszentwellenspektroskopie mit niedermodigen Wellenleitern." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963831402.
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Söderlind, Klara. "Min tröja håller mig varm." Thesis, Malmö universitet, Fakulteten för kultur och samhälle (KS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-21603.
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I denna studie undersöks hur man genom produktdesign kan ändra relationen till kläder genom att främja vikten av fysisk funktion. Syftet har varit att belysa vår relation till kläder för att på sikt minska klädkonsumtionen för en ekologisk hållbar utveckling. Genomförandet av studien har inneburit insamling av empiriskt material genom framförallt prober och kvalitativa intervjuer. Studien grundar sig på innehållet i det teoretiska ramverket som innefattar teorier inom kritisk design, funktion och ekologisk hållbar utveckling. Slutsatsen visar att bristen av en viss typ av funktioner får oss att sätta högre värde på den. Den visar även att om man vill visa värdet av fysisk funktion genom att i viss mån utesluta den, är det viktigt att i viss mån inkludera icke-fysisk funktion för att användaren ska kunna relatera till produkten. Den produkt som studien resulterat i är endast ett exempel på hur man kan manipulera funktioner för att starta debatt.In this study research is conducted on how, through product design, our relation to clothes can be changed by promoting physical function. The aim has been to cast light upon our relation to clothes in order to reduce the consumption of clothes, for an ecologically sustainable development. The execution of the study has consisted of the gathering of empirical data, mainly by use of probes and qualitative interviews. The study is based on a theoretical framework comprised of theories in critical design, function and ecologically sustainable development. The conclusion shows that the lack of a certain type of function makes us assign higher value to it. It also shows that if one desires to demonstrate the value of physical functions by excluding some of them entirely, it is important to include some degree of non-physical function, for the user to be able to relate to the product. The product in which the study resulted, is but one example of how functions may be manipulated in order to spark debate.
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Svärling, Sofie. "Den andra världen i barn- och ungdomslitteraturen : Funktion och gestaltning." Thesis, Uppsala universitet, Litteraturvetenskapliga institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-155314.
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Castro, Esparza Alejandra. "Algoritmo Genético para el problema de formación de Células de Manufactura con secuencia." Thesis, Universidad de las Américas Puebla, 2013. http://catarina.udlap.mx/u_dl_a/tales/documentos/mid/castro_e_a/.
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En esta tesis se estudia el Problema de Formación de Células de Manufactura
(MCFP por sus siglas en inglés) que considera la secuencia de las partes, se
aplica un algoritmo genético para resolver este problema. El algoritmo intenta
reducir al máximo los movimientos intercelulares, asignado cada máquina a la
célula más conveniente de tal manera que se minimicen dichos movimientos.
El algoritmo propuesto utiliza un procedimiento de búsqueda local para
mejorar la calidad de las soluciones. El algoritmo propuesto obtiene buenos
resultados ya que tuvo la capacidad para encontrar todos los resultados
óptimos para todas las instancias de prueba por lo menos en una ocasión.
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Rezazadeh, Baee Mir Ali. "Privacy-preserving authentication and key management for cooperative intelligent transportation systems." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/212412/1/Mir%20Ali_Rezazadeh%20Baee_Thesis.pdf.
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Car accidents kill or injure millions of people. Cooperative Intelligent Transportation Systems (C-ITS) can increase road safety and reduce accidents through the application of information and communication technologies for communicating vehicles. However, C-ITS applications are vulnerable to potential cyber-attacks involving message manipulation, where messages may be altered intentionally or fake messages sent, compromising the safety goals. Cryptographic techniques can be used to solve this, but this must be done in a way that preserves driver privacy, so that unauthorized surveillance and tracking of drivers is not possible. This research develops a secure conditional privacy-preserving authentication scheme for C-ITS applications.
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Santos, Cicero Antonio Mariano dos. "Influência da chuva na eficácia de Bacillus thuringiensis associado a adjuvantes no controle de Spodoptera frugiperda em algodão /." Jaboticabal, 2019. http://hdl.handle.net/11449/191220.
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Orientador: Marcelo da Costa FerreiraResumo: O algodão (Gossypium hirsutum L.) tem grande relevância para a economia mundial. Dentre os principiais fatores limitantes da produção estão os problemas fitossanitários, que ocorrem em todas as fases da cultura. O inseto Spodoptera frugiperda (JE Smith) (Lepidoptera: Noctuidae) é importante devido a sua capacidade de causar danos nas folhas e maçãs do algodoeiro, muitas vezes requerendo a aplicação frequente de inseticidas para o seu controle. Em geral são utilizados inseticidas químicos. Entretanto, o uso de bioinseticidas têm aumentado consistentemente, principalmente aqueles à base de Bacillus thuringiensis, chamados de Bt bioinseticidas. Fatores abióticos como a chuva também interferem na eficiência de aplicações de Bt bioinseticidas e consequentemente no controle do organismo alvo. Uma alternativa que pode dar proteção ao Bt mediante chuva é a adição de adjuvantes a calda. Porém, pouco se sabe o quanto a associação do Bt com adjuvantes afeta no crescimento vegetativo, esporulação e persistência da bactéria e o controle. Portanto é de extrema importância à compreensão das interações físico-químicas e biológicas da mistura de Bt bioinseticidas e adjuvantes. Neste contexto, objetivou-se avaliar o efeito da adição de adjuvantes nas características físico-química e biológicas dos Bt bioinseticidas nas formulações Dipel® WP e Dipel® SC submetidas à chuva artificial para o controle de S. frugiperda em plantas de algodão. Para simular a chuva, foram utilizadas as lâminas de chuv... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Cotton (Gossypium hirsutum L.) has great relevance to the world economy. Among the main limiting factors of production are the phytosanitary problems that occur at all stages of the crop. The insect Spodoptera frugiperda (JE Smith) (Lepidoptera: Noctuidae) is important because of its ability to cause damage to cotton leaves and apples, often requiring insecticides to be applied frequently for its control. In general, chemical insecticides are used. However, the use of bioinsecticides has consistently increased, especially those based on Bacillus thuringiensis, called Bt bioinsecticides. Abiotic factors such as rain also interfere with the efficiency of Bt applications and consequently in the control of the target organism. An alternative that can protect Bt in the rain is the addition of adjuvants to the syrup. However, little is known about how the association of Bt with adjuvants affects vegetative growth, sporulation and bacterial persistence and control. Therefore, it is extremely important to understand the physicochemical and biological interactions of the mixture of Bt bioinsecticides and adjuvants. In this context, the objective of this study was to evaluate the effect of the addition of adjuvants on the physicochemical and biological characteristics of Bt bioinsecticides in the formulations Dipel® WP and Dipel® SC submitted to artificial rain to control S. frugiperda in cotton plants. To simulate the rain, the 20mm artificial rain blades applied one hour after the ap... (Complete abstract click electronic access below)
Doutor
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Peral, Marion. "Calibration of the clumped-isotope thermometer in foraminifera and its application to paleoclimatic reconstructions of the mid-Pleistocene in the Gulf of Taranto." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS382/document.
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Quantifier les variations de température océanique du passé est nécessaire pour comprendre les mécanismes qui régissent l’évolution climatique. Les méthodes de paléo-thermométrie classiques peuvent souffrir de limitation inhérente à l’écologie des organismes et/ou à cause de l’influence d'effets physico-chimiques (salinité, acidité de l’eau de mer…). Ce travail se focalise sur la technique de paléothermométrie Δ47, qui repose sur la mesure du « clumping isotopique » dans les carbonates. Il vise d’abord à établir une calibration appliquée aux foraminifères et ensuite à mettre en œuvre cette calibration pour l’étude des variations climatiques au cours de la transition du Pléistocène moyen (MPT). Notre calibration Δ47-température des foraminifères planctoniques et benthiques, prélevés dans des sédiments modernes, couvre une gamme de température de -2 à 25°C. Les valeurs de Δ47 sur 9 espèces de foraminifères présentent une excellente corrélation avec la température de calcification des organismes, estimée à partir des mesures isotopiques de l’oxygène. Les résultats obtenus confirment l’absence d’effets liés à l’écologie des foraminifères (effets vitaux et de taille des organismes) et démontrent que la salinité n’affecte pas les mesures de Δ47. Cette étude constitue une avancée méthodologique importante pour les futures études paléocéanographiques sur les foraminifères. La MPT correspond à une transition climatique marquée par un changement de fréquence des cycles glaciaires-interglaciaires (de 41 000 à 100 000 ans). La compréhension de cette période est un enjeu scientifique majeur pour appréhender la mise en place du climat actuel. Notre calibration Δ47-température a permis de quantifier les variations de températures au cours de la MPT en mer méditerranée (Section de Montalbano Jonico, sud de l’Italie) et particulièrement des stades isotopiques marins 31 et 19, considérés comme des analogues à l’Holocène. Les résultats indiquent que (i) les températures (Δ47) obtenues sont en adéquation avec les températures obtenues par d’autres paléothermomètres, (2) les températures permettent de retracer les changements de régime océanographique et hydrologique, et (3) la mesure du Δ47 est complément prometteur pour les études multi-méthodes en paléocéanographieThe quantification of past oceanic temperature changes is a critical requirement for understanding the mechanisms which regulate climate variations. Classical methods of paleothermometry could suffer from well-known limitations related to ecology and/or to physico-chemical biases (sea water salinity, acidity…). This work focuses on clumped-isotope carbonate thermometry (Δ47). It aims to establish a calibration of Δ47 foraminifera and use it to study past climatic variations through the Mid-Pleistocene Transition (MPT). Our Δ47 calibration in planktonic and benthic foraminifera collected from modern marine sediment covers a temperature range of -2 to 25 °C. The clumped-isotope compositions of 9 species of foraminifera show a robust correlation with the calcification temperature, estimated from the measurements of oxygen-18. These results confirm the absence of bias linked to foraminifer ecology (species-specific and foraminifer size effects) and provide evidence that salinity does not affect the Δ47 thermometer. This study constitutes significant methodological progress for future paleoceanographic applications in foraminifera.The MPT is a climatic transition characterized by a shift in the frequencies of glacial-interglacial cycles (from 41 000 to 100 000 years). Understanding the MPT is a major scientific objective, which underlies our effort to study the establishment of our present climate. Our Δ47 calibration was used to quantify temperature changes through the MPT in the Mediterranea Sea (Montalbano Jonico section, south of Italy), and in particular the marine isotopic stages 31 and 19, which may be described as Holocene analogues. We find that (1) Δ47 temperatures are in good agreement with temperatures reconstructed from other paleothermometers, (2) these results allow reconstructing changes in past oceanographic and hydrologic regime, and (3) Δ47 measurement are a promising component of multi-proxy paleoceanographic studies
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Isacson, Terese. "Mio i folksagan och karnevalen : En tolkning och narratologisk studie av Astrid Lindgrens verk Mio, min Mio." Thesis, Högskolan Dalarna, Litteraturvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:du-21007.
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The purpose of the study is, based on a narratological perspective, to analyze and interpret the novel written by Astrid Lindgren: Mio, min Mio. It is based on the legacy of the folktale tradition, which is also the basis for carnival concept according to Bachtin. The study is based on a narrative model of Gérard Genette. Mio, min Mio is told as a first person narrator and can be interpreted as Bo tells it to himself. It is a frame story in which the outer story is the reality, while the inner story is the structure of the folktale where Mio embarks on a predetermined mission to fight against evil. Carnival concept involves a timed up-and-down-turn that is sanctioned and controlled, this fits well with this story seen from this interpretation. In the fantasy world everything has an idealized counterpart and Bo is, via Mio, in this world for a limited time. Children in our society are powerless, but are allowed to be mighty in children's literature. The story gets a subversive effect as it shows that adult standards are not absolute. Even if Bo turns back to his foster parents, he goes through this inner battle processing his thoughts and feelings. The love Bo will experience in imagination gives him the power to manage his real situation.
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Gunnarsson, Elin. "Barnet i litteraturen : - En jämförande analys av Nils Holgersson, Mio, min Mio och Monsterakademin." Thesis, Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-50897.
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McFarlane, Ann. "The god Min to the end of the Old Kingdom /." Sydney : the Australian centre for Egyptology, 1995. http://catalogue.bnf.fr/ark:/12148/cb37058993m.
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Kolářová, Jana. "Marketingová komunikace vybraných společností." Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-197206.
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This thesis deals with an analysis of marketing communication in two selected companies operating multiplexes. It is Premiere Cinemas Czech s.r.o and Cinestar s.r.o. The thesis is devided into a theoretical and practical part. Theoretical part focuses on marketing mix of services and particularly communication mix. Practical part compares marketing mix of both companies, their differences in individual parts and it aims at the tools of communication mix, especially sales support tools. This work also includes a questionnaire survey investigating whether respondents distinguish between individual companies and if they know and use sales support tools of multiplexes. Some recommendations have been suggested based on this.
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Mirošová, Leona. "On-line marketingová komunikace." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2020. http://www.nusl.cz/ntk/nusl-414478.
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The master’s thesis focuses on the online marketing communication of the fashion brand Sledgehammer. The thesis acquaints with the current structure of the communication mix and online marketing communication and, based on performed analyses and its own research, suggests appropriate suggestions to improve the communication of Sledgehammer with the public.
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Veselý, Tomáš. "Návrh komunikačního mixu vybraného podniku." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2018. http://www.nusl.cz/ntk/nusl-377435.
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The goal of the thesis is, based on analysis of the current state of the communication mix of selected company, to propose specific measures, which will lead to their improvement. This thesis is divided into three parts – theoretical, analytical and propositional. The theoretical part is dealing with defining theoretical background which serves as the basis for the development of analytical and propositional part. In the second part is introduced the selected company and are performed the analysis of current state of the communication mix. Results of these analyses are used in the third part of the thesis, which describes the measures to improve the current communication mix of the company.
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Havlíčková, Barbora. "Návrh marketingového mixu v oblasti služeb." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2014. http://www.nusl.cz/ntk/nusl-224454.
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This master´s thesis deals with the assessment of the current state of the marketing mix business entity providing manicure and pedicure services and suggestions for improvement. In the theoretical section provides the theoretical background associated with the problem. analytical part deals with basic information about the business entity application marketing analysis and evaluation of the survey. The practical part is based on the analysis results and the survey deals with a recommendation proposing changes to the marketing mix to ensure widespread awareness on services of the business entity.
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Čarná, Lenka. "Návrh změn v marketingovém mixu společnosti podnikající v HoReCa sektoru." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2016. http://www.nusl.cz/ntk/nusl-234815.
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The thesis is focused on a proposal for changes in the marketing mix of companies operating in HoReKa sector, specifically in the restaurant area. The thesis analyzes the current position on the market, the competition and the internal and external environment in which it operates. Thesis contents proposals for measures and changes to improve the current status of the company.
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Lišková, Barbora. "Návrh komunikačního mixu vybraného podniku." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2016. http://www.nusl.cz/ntk/nusl-241617.
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The goal of the thesis is to propose measures to improve the communication mix based on the analysis of current state of the communication mix of the company. The Thesis is dividend into theoretical, analytical and proposition part. The teoretical part is to introduce the teoretici background needed for analyzing analytical and proposal part. . Second part contains the introduction of the company and the analysis of current situation. In the proposition partdelas with a proposal of measures to improve the current state of the communication mix of the company.
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Havlíková, Petra. "Návrh komunikačního mixu vybraného podniku." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2017. http://www.nusl.cz/ntk/nusl-319211.
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The goal of the thesis is, based on analysis of the current state of the communication mix of selected company, to propose specific measures to improve it. The Thesis is divided into three parts, namely theoretical, analytical and propositional. In the theoretical part are defined theoretical background, which serves as the basis for the development of analytical and propositional part. In the practical part is introduced the selected company and are performed the analysis of current state of the communication mix. Analysis results are used in the propositional part of the Thesis, which describes the measures to improve the current communication mix of the company.
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Orre, Christoffer, and Karl Boman. "Gör mig delaktig i min vård! : En litteraturstudie om bedsiderapportering." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-347780.
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Bakgrund: Personcentrerad omvårdnad är något som läggs stor vikt vid i dagens sjukvård. I och med detta får sjuksköterskor större ansvar genom att sätta patienten i fokus. Traditionella överrapporteringar utförs utan patientens närvaro samtidigt som det finns en rapporteringsmetod som istället inkluderar patienten, vilket är bedsiderapportering. Bedsiderapportering är relativt nytt och forskning har främst undersökt sjuksköterskornas perspektiv. Dessutom är traditionella överrapporteringar inte i enlighet med de lagar som styr vården idag. Syfte: Syftet var att belysa patientens upplevelse av bedsiderapportering inom slutenvården. Metod: En litteraturstudie med 10 kvalitativa studier, som kvalitetsgranskades. Resultatanalysen gjordes med hjälp av en kvalitativ metod. Resultat: Generellt upplevde patienter en aktiv delaktighet samtidigt som önskan även framkom om mera delaktighet medan andra uppskattade en mer passiv roll. Språket som sjuksköterskor använde under överrapporteringen upplevdes som svårförståeligt. Bedsiderapportering möjliggjorde för patienter att få mer kunskap om sin vård och om sjuksköterskornas arbete. Patienter upplevde att sjuksköterskor skyddade deras integritet, samtidigt som andra patienter upplevde att sjuksköterskor inte uppmärksammade patienten som en person. Patienter förklarade att de kände sig mer trygga med sin vård då de visste att informationen från föregående sjuksköterska hade överlämnats till den kommande sjuksköterskan. Patienter upplevde att de behandlades som en person i första hand och en patient i andra hand. Slutsats: Eftersom patienter upplevde bedsiderapportering som inkluderande så kan metoden för överrapportering mellan sjuksköterskor ses som ett alternativ till den traditionella för att vården ska vara uppdaterad i enlighet med Patientlagen. Patienter upplevde inte att integriteten var ett bekymmer, vilket tidigare forskning har spekulerat som problematiskt. Mera forskning behövs utifrån patientens upplevelse av bedsiderapportering då forskning saknas.Background: Person-centered nursing is something that attaches great importance to today's healthcare. With this, nurses become more responsible by focusing on the patient. Traditional nursing handovers are performed without the patient's attendance while there is a reporting method that includes the patient, which is bedside nursing handover. Bedside nursing handover is relatively new and research has primarily examined the nurses' perspective. In addition, traditional nursing handover are not in accordance with the laws governing health care today. Aim: The aim was to illuminate the patient's experience of bedside nursing handover in the field of primary care. Method: A literature study with 10 qualitative studies was used, which was quality-reviewed. The results analysis was done using a qualitative method. Results: Generally, the patients experienced active participation, while also wishing to see more involvement while others appreciated a more passive role. The language that nurses used during the handover were perceived as difficult to understand. Bedside nursing handover enabled patients to gain more knowledge about their care and the nurses' work. Patients perceived that nurses protected their privacy while other patients experienced that nurses did not pay attention to the patient as a person. Patients explained that they felt more secure with their care as they knew that the information from the previous nurse had been handed over to the oncoming nurse. Patients felt that they were treated as a person primarily and a patient secondly. Conclusion: Since patients experienced bedside nursing handover as inclusive, the method of handover between nurses can be seen as an alternative to the traditional nursing handover in care since it is updated in accordance with the Patient Act. Patients did not experience integrity as a concern, as previous research has speculated as problematic. More research on the patient's experience of bedside nursing handover is needed as research is lacking.
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Vesterberg, Albin. "Skriva musik för gitarrtrio : reflektioner om mig och min konst." Thesis, Kungl. Musikhögskolan, Institutionen för jazz, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kmh:diva-2059.
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Cajonberg, Julia. "”Jag blir alldeles pirrig när min fröken skahögläsa för mig, för jag lär mig så mycket”." Thesis, Mittuniversitetet, Institutionen för utbildningsvetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-36961.
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Šléglová, Miroslava. "On-line marketingová komunikace." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2021. http://www.nusl.cz/ntk/nusl-442921.
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The master’s thesis is focused on the on-line marketing communication of the brand Pěkný domov shop. The thesis acquaints with the current structure of the communication mix and the online marketing communication and based on the performed analyses and own research, suggests the appropriate suggestions to improve the on-line communication of Pěkný domov shop with the public.
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Gacíková, Denisa. "Porovnanie marketingových aktivít spoločnosti Kofola a spoločnosti Coca Cola." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-16715.
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The work focuses on the analysis of the marketing activity of the both companies emphasizing the communication mix. The theoretical part is dedicated to the marketing mix, its components and its application for the global and local company. Mill's theory of the comparative research closes this chapter. The practical part aims at the communication mix development in both companies from 2001 until 2009 and it finishes with the Mill's theory of agreement, where all of the attributes obtained during the mentioned period are applied to praxis. The last part declares the comparison of the particular elements.
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Černohorská, Karolína. "Uvedení nového produktu Bonduelle na český trh." Master's thesis, Vysoká škola ekonomická v Praze, 2016. http://www.nusl.cz/ntk/nusl-262326.
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The thesis is focuse on contemporary brand marketing, which these days is increasingly facing with oversupply and increasing competition. More than ever before, marketing is becoming the most important components of the company management, especially in FMCG companies. In the theoretical part I deal with the key concepts of marketing and describe in detail the marketing and the communication mix of B2C companies. I will get to the topic of brand marketing and the areas associated with it, such as marketing research, marketing and communications strategies based on business objectives. In the practical part the reader will get a chance to see the detailed proces of new product launch onto the Czech market within the canned vegetables segment and the retail chain. In the first half I will describe the product launch and the steps taken with regards to communication. I will describe the current market trends within the pickled vegetable´s market and the development of competitive brands, especially the problem of the growing influence of private labels. The second part will describe the communication mix of the launched novelty and the proposed changes based on the findings. At the end I will propose the new ATL support for the novelty
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Ježková, Jaroslava. "Rizika v oblasti řízení marketingové komunikace." Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-401082.
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This diploma thesis deals with marketing communication topics of particular hairdresser’s and related risks. The work consists of theoretical background, problems analysis and current situation, description of the research itself and risk analysis. The analysis results are utilized to propose solutions which should lead to change of communication mix. The risk analysis is also applied on proposals of solutions.
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Hichri, Haitem. "Überwachung und Optimierung des MSG-Schweissprozesses mit Hilfe von KI-Methoden und Spracherkennungsalgorithmen /." Aachen : Shaker, 2005. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014196638&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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Čepová, Renáta. "Návrhy na zlepšení komunikačního mixu." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2016. http://www.nusl.cz/ntk/nusl-241643.
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The purpose of this diploma thesis is to propose solutions which will lead to improvement of the communication mix as well as to an increase in the number of atendees of the dance festival. The theoretical part introduces the fundamental terms, related to the communication mix, and the latest trends as well. The analytical part consists of the processed analyses and the questionnaire enquiry. On the basis of information obtained in the theoretical part, individual solution proposals are derived from the analyses and the questionnaire enquiry.
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Andžič, Vedrana. "Zavedení nového výrobku na trh." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-85273.
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The aim of this Master's thesis is description of new electric water heater launch process. The theoretical part of the thesis deals with marketing mix and goes deeper in explanation of product lifecycle theory. Theoretical part is the basis for practical part. Practical part describes company Ariston Thermo in brief and deals with technical parameters of new electric water heater VELIS as well as distribution and price policy during the launch process. The key part of the thesis is dedicated to analysis of communication mix tools used during the first phase of product lifecycle, it's costs and impact. There is a short recommendation for growth phase in conclusion of the thesis.
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Ebrahimi, Faeza. "Regulation of colorectal cancer metastasis by modulating mitochondrial miRNAs." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/380062.
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Background
Cancer is one of the major contributors to mortality and morbidity worldwide.
Current literature demonstrates that by the age of 85 years, 1 in 2 males and 1 in 3
females in Australia will have been diagnosed with cancer at some stage in their life.
Cancer occurs due to external and or internal stimuli to cells causing them to respond by
dividing uncontrollably and growing aberrantly. This abnormal development later forms
into solid malignant tumours, which gain the ability to invade and destroy adjacent
tissue and disseminate to distant organs of the body via the general circulatory
or lymphatic system of the host. While there are many treatment modalities that exist to
treat cancers, complete cure may or may not occur due to high tendency of cancer
recurrence.
This study sets emphasis on the regulation of colorectal cancer (CRC) metastasis
by modulating mitochondrial microRNAs. Cancer of the colon and rectum is the most
prevalent cancer in Australia after breast and prostate cancer in both genders and the
second most frequent cancer-related cause of death. Numerous literatures indicate that
specific microRNAs are aberrantly expressed in various cancers including colorectal
cancer. Micro-ribonucleic acids (miRNAs) are small (17–25 bases) single-stranded,
evolutionarily conserved, non-coding RNAs that play a key role in the regulation of
gene expression during essential cellular processes like cell differentiation, cell cycle
progression, stress response and apoptosis. Mitochondrial miRNAs (Mitomirs) are those
pre-miRNAs that mature in the mitochondria to regulate mRNAs related to
mitochondrial function. While some mature miRNAs also translocate to and function in the mitochondria.
Earlier studies have shown that mitochondrial dysfunction is linked with cancer
pathogenesis. This can be controlled by overexpression of tumour suppressor miRNAs
via targeting specific messenger RNAs (mRNAs). This study has focused on four key
microRNAs (miR-126, miR-15a, miR-145, and miR-335), which has a significant role
in regulating mitochondrial function. The role of these miRNAs in the modulation of
mitochondrial function in colorectal cancer has not been previously studied. For the first
time the expression and clinicopathological parameters of miR-335 and miR-145 have
been investigated in colorectal cancer.
Aims and hypothesis
This research is proposed to investigate the functions of mitochondrial miRNAs
miR-126, miR-15a, miR-145, and miR-335 in metastatic colorectal cancer tissues and
cell lines, to determine their role in regulating of colorectal cancer.
The hypotheses to be tested were: (1) miRNA expression will be altered in
different stages of colorectal cancer tissues and cell lines compared to control groups;
(2) expression of miRNAs will have a correlation with the clinicopathological features
of patients with colorectal cancer (3) miRNA expression levels will differ in different
stages of colorectal cancer; (4) in-vitro studies will show tumour suppressive roles of
these miRNAs; (5) expression of tumour suppressor miRNA will target genes to
regulate colorectal cancer; (6) mitochondrial respiration will be increased by the ectopic expression of these miRNAs compared to control groups.
Materials and methods
Tissue samples were recruited from patients at Gold Coast University Hospital in
Queensland, Australia. Ethical approval for this study was obtained from the Griffith
University Human Research Ethics Committee (GU Ref No: MSC/17/10/HREC).
Colorectal tissues from 163 primary adenocarcinomas, 96 matched metastatic lymph
node, 48 distant metastatic, 40 adenocarcinomas and 42 non-neoplastic tissues were
recruited from 389 patients and used to check the expression of miR-126. Post
histopathological analysis, 182 tissue samples from 124 patients (37 non-neoplastic, 87
primary adenocarcinomas, 50 matched metastatic lymph node, and 8 distant metastatic)
samples were used to examine the expression of miR-15a; a total of 185 tissue samples
comprising of 37 non-neoplastic, 90 primary adenocarcinomas, 50 matched metastatic
lymph node, and 8 distant metastatic samples were used to examine expression of miR-
145 and finally a total of 101 tissue samples comprising of 16 non-neoplastic, 59
primary adenocarcinomas, 18 matched metastatic lymph node, 8 distant metastatic
samples were used to examine expression of miR-335.
Histopathological samples (non-tumour, pre-cancerous and cancerous lesions)
were collected and the clinical characteristics were recorded with the help of clinicians.
The miRNA of the selected samples was extracted by standard protocols. miRNA
expressions were then studied by evaluating the quantitative amplification using
quantitative real-time polymerase chain reaction (qRT-PCR). ΔΔCT and CT ratio
methods were used to analyse gene expression. All miRNA expressions were correlated
with clinical and pathological data. miRNA mimics and Hiperfect transfection reagents
were used to identify post transfection alterations in colon cancer cell lines.
Functional assays including MTT calorimetric, cell cycle analysis, apoptosis,
colony formation, and basement membrane assays were performed with an exogenous
microRNA mimic to detect any in-vitro changes in cancer cell biology. Western blot
analysis was used to detect the target genes of Mitomirs. Targets such as p53, BCL-2,
KRAS, TAB3, FAM134B, SOX2, and VEGF-A were tested. Mitochondrial respiration
was also examined through the addition of mitochondrial inhibitors oligomycin,
carbonyl cyanide-ptrifluoromethoxyphenylhydrazone (FCCP), and rotenone/antimycin
A, and analysed via Seahorse XF analyser serially 24 hours and 36 hours after
transfection.
Results
Expression levels of miR-126, miR-15a, miR-145, and miR-335 in CRC tissues
and cancer cell lines were significantly downregulated compared to normal tissues and
cell lines. Ectopic expression of miRNAs: miR-126, miR-15a, miR-145, and miR-335
showed reduced cell proliferation, colony formation, and invasion compared to control
groups. Target protein analysis showed that miR-126 reduced expression of BCL-2,
while increased p53 and KRAS. On the other hand, miR-15a reduced expression of
BCL-2, and SOX2 while TAB3, and FAM134B showed no changes. Overexpression of
miR-145 reduced expression levels of p53 and VEGF-A, while no changes were noted
in expression levels of SOX2 protein. miR-335 repressed expression of KRAS and
VEGF-A. Mitochondrial functions evaluated through use of mitochondrial inhibitors,
illustrated that oxygen consumption rate (OCR), extracellular acidification rate (ECAR),
maximal respiratory capacity, spare respiratory capacity, ATP coupled respiration, and
proton leak in SW480miR-126, SW480miR-15a, SW480miR-145, and SW480miR-335 cells, were
elevated compared to scramble miRNA and wild-type as control post 24 hours of
transfection. Post 36 hours of transfection we observed that the mitochondrial respiration in colon cancer cells with ectopic expression of miR-126, miR-15a, miR-
145, and miR-335 was reduced compared to their respective control groups.
Conclusion
To conclude, expression analysis of miRNAs (miR-126, miR-145, miR-335 and
miR-15a) showed significant downregulation in colorectal adenocarcinomas with
advanced pathological stages, indicating their roles in colorectal cancer pathogenesis.
Moreover, in vitro studies implicated that the ectopic expression of miRNAs reduces
CRCs proliferation, colony formation, and invasion and can induce apoptosis. Also,
increased expression of miRNAs in colon cancer cells reduces the viability of cancer
cells, potentially via suppression of growth promoting genes (BCL-2, KRAS, VEGF-A,
and SOX2) and up-regulation of tumour suppressor genes (p53). Mitochondrial
respiratory components such as OCR, ECAR, maximal respiratory capacity, spare
respiratory capacity, ATP coupled respiration, and proton leak were notably increased
while the metabolic potential was reduced in both miR-126 and miR-335 overexpressed
colon cancer cells 24-hours after transfection. Moreover, the mitochondrial inhibition in
colon cancer cells with ectopic expression of miRNAs post the 36 hours of transfection
resulted in overall repressed mitochondrial respiration capacity. In summary, this study
highlights that the dysregulation of miRNAs can modulate mitochondrial respiration and
can regulate cancer cell biology via targeting various tumour-related proteins. This study
in future will lead to the development of targeted therapies for patients with colorectal carcinomas with a specific focus on cancer cell mitochondria and miRNAs.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medicine
Griffith Health
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Novotná, Lenka. "Komunikační mix podniku." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2018. http://www.nusl.cz/ntk/nusl-377415.
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Diploma thesis deals with communication mix of company Zahradní centrum V Aleji. The theoretical part of the thesis defines the basic concepts from marketing, marketing mix and communication mix. The analytical part of the thesis describes the current situation of the company, analysis macro environment and micro environment, marketing research and SWOT analysis. At the end of the thesis are presented suggestions which should lead to improvement of the communication mix.
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Fikejzová, Kristýna. "Marketingová komunikace podniku." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2018. http://www.nusl.cz/ntk/nusl-377580.
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This diploma thesis deals with the marketing communication of the company Kostka-kolobka s.r.o. In the theoretical part are characterised important concepts related to marketing and marketing communication. The second part is focused on the introduction of the company and the description its current situation using marketing analyzes and questionnaire survey. The findings are summarized in the SWOT analysis. Based on the results from the analytical section, in the third part of the thesis are presented the suggestions to improve marketing communication.
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Horáková, Pavla. "Návrh komunikačního mixu pro prodej potravin." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2018. http://www.nusl.cz/ntk/nusl-377635.
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The focus of this master thesis is the marketing communication mix for an enterpreneur, who runs a grocery store business. On the basis of the theoretical knowledge, the analyzis of the current state of marketing comunnication was conducted. Following this analyzis, suggestions have been made on how to improve the existing communication mix for the grocery store, which will increase business awareness, attract new customers and lead to increased sales.
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Jamborová, Markéta. "Komunikační mix společnosti Tovares s.r.o." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2013. http://www.nusl.cz/ntk/nusl-223855.
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This diploma thesis focus on suggestions of the suitable communication mix, which is coming out of the analysis of the current situation in Tovares s.r.o. company. This company is failing to compete and break through on the market. The company is engaged in the production and distribution of the wide range of equipment and accessories needed for the hairdressing – starting with furniture, complete range of the equipment and technology, chemical preparations, finishing with the combs and hairpins. This work is supposed to help as the source of the information while implementing new suitable communication mix. This communication mix contains a suggestions which aim is to approach new customers and to retain the existing ones.
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Mizerová, Petra. "Návrh komunikačního mixu podnikatele Mgr. Lumíra Bednaříka." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2014. http://www.nusl.cz/ntk/nusl-224381.
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Master's thesis contains proposals for improvement of communication mix by entrepreneurial subject Mgr. Lumír Bednařík that is engaged in selling woodworking tools, wooden derivatives, plastics and light alloys. Thesis is supposed to be a basis for implementation of effective communication mix which contains proposals and recommendations whose objective is to strengthen relations with current customers and finding new ones. Execution of these proposals should lead to growth of businessman’s profit.
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Vlašínová, Radka. "Komunikační strategie společnosti PLASTIC BOX CZ, s.r.o." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2016. http://www.nusl.cz/ntk/nusl-241433.
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The content of this diploma thesis is to elaborate a complete communication mix of PLASTICBOX CZ, Ltd. The study is divided into a theoretical and a practical part. The first part analyzes in detail the theoretical basis of individual marketing tools, which are tested in the second part.
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Švecová, Michaela. "Marketingové aktivity společnosti působící na realitním trhu." Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2017. http://www.nusl.cz/ntk/nusl-317085.
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This diploma thesis is focused on the analysis of marketing activities in the company Century 21 All Inclusive which deals mostly with selling and renting real estates. The work includes the theoretical part where there are several terms concerning marketing and real estate market analysed, the second part involves the introduction of the company and the execution of the particular analyses and the third part introduces further suggestions for solutions which will lead to the improvement of the marketing communication of the company.
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Kan, Casina. "The role of Dysregulated Microrna in Ovarian Cancer." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/10108.
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Ovarian cancer is the most lethal gynaecological malignancy and the sixth most common cause of cancer death in Australian women. Epithelial ovarian cancer accounts for 90% of ovarian cancers, of which, serous epithelial ovarian cancer is the most common and aggressive histological subtype. MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that negatively regulate genes involved in cancer. Genomic instability is a hallmark of ovarian cancer which may be exacerbated by DNA hypomethylation. The role of aberrant methylation and copy number variation (CNV) on miRNA dysregulation was assessed by qPCR methylation arrays and integrative analysis of cytogenetic arrays, miRNA expression and gene expression profiles. Several miRNAs identified to be adjacent to CpG islands aberrantly methylated or located in regions of CNV. Of these, the mir-23a/mir-24-2/mir-27a cluster and mir-425 were identified to be in regions of CNV and were predicted to target oncogenic receptor tyrosine kinases AXL and MET. Furthermore, one of the unmet needs for ovarian cancer patient survival is reliable detection. Current diagnostic tests for ovarian cancer may be improved by expansion of biomarker panels such as circulating miRNAs. Assessment of miRNA expression profiles identified the miR-200 family to be over-expressed in ovarian cancer patient serum.
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Muñoz, Gorriz Jordi. "Degradación y conducción multifilamentaria en estructuras MIS/MIM basadas en HfO2." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/671616.
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En aquesta tesi doctoral es realitza una extensa investigació sobre el fenomen de la ruptura dielèctrica en dispositius metall-aïllant-semiconductor (MIS) i metall-aïllant-metall (MIM) basats en HfO2. Més específicament, s’han estudiat dispositius MIS/MIM amb HfO2 com a dielèctric i dispositius MIS dielèctric dels quals es un penta-nanolaminat composat per capes interposades de HfO2 i de Al2O3. Al llarg dels quatre extensos capítols que formen aquesta tesi, més un últim capítol conclusiu, s’ha realitzat un exhaustiu estudi de la ruptura dielèctrica des de punts de vista completament diferents. Iniciant per un capítol introductori al fenomen de la ruptura dielèctrica, en el que s’exposa els aspectes generals a tenir en compte, cadascun dels tres capítols experimentals posteriors giren al voltant d’un efecte particular d’aquest fenomen. A la vegada, només s’avalua un tipo de dispositiu en cada capítol. Inicialment, utilitzant les estructures MIS basades en HfO2, es realitza un anàlisis en profunditat dels canvis estructurals induïts en la intercara metall-aïllant dels dispositius degut a la ruptura dielèctrica. Per a fer-ho, en aquest capítol es recorren a poderoses tècniques de caracterització física como el microscopi electrònic de rastreig, el microscopi de forces atòmiques o la espectrometria de dispersió de energia de raigs X. A la vegada, es realitza un estudi sobre els efectes de la commutació resistiva en els canvis induïts en els dispositius. En el següent capítol, utilitzant les estructures MIS basades en HfO2/Al2O3, es realitza un anàlisis de la estadística de la ruptura dielèctrica dependent del temps, així com dels esdeveniments de ruptura successius. Utilitzant un gran arsenal de models i tècniques estadístiques, s’aconsegueix reproduir les tendències experimentals el quals no son reproduïbles amb el model de Weibull, indicació d’una ruptura dielèctrica no homogènia. A la vegada, es proporciona una hipòtesis que permet explicar el comportament observat. Seguidament, en l’últim capítol experimental, es realitza un anàlisis exhaustiu i extens de la estadística espacial dels esdeveniments de ruptura mitjançant els dispositius MIM basats en HfO2. Utilitzant aquestes tècniques, s’aconsegueix avaluar la correlació entre els esdeveniments de ruptura, així com la que existeix entre la localització i la mida dels esdeveniments. Finalment, en el capítol conclusiu es presenten tant les conclusions més rellevants de la investigació realitzada com una valoració dels possibles nous estudis que s’originen d’aquest treball.En esta tesis doctoral se realiza una extensa investigación sobre el fenómeno de la ruptura dieléctrica en dispositivos metal-aislante-semiconductor (MIS) y metal-aislante-metal (MIM) basados en HfO2. Más específicamente, se han estudiado dispositivos MIS/MIM con HfO2 como dieléctrico y dispositivos MIS cuyo dieléctrico es un penta-nanolaminado compuesto por capas interpuestas de HfO2 y de Al2O3. A lo largo de los cuatro extensos capítulos que conforman esta tesis, más un último capítulo conclusivo, se ha realizado un exhaustivo estudio de la ruptura dieléctrica desde puntos de vista completamente diferentes. Empezando por un capítulo introductorio al fenómeno de la ruptura dieléctrica, en el que se exponen los aspectos generales a tener en consideración, cada uno de los tres capítulos experimentales posteriores giran en torno a un efecto particular de este fenómeno. A su vez, solo se evalúa un tipo de dispositivo en cada capítulo. Inicialmente, utilizando las estructuras MIS basadas en HfO2, se realiza un análisis en profundidad de los cambios estructurales inducidos en la intercara metal-aislante de los dispositivos debido a la ruptura dieléctrica. Para ello, en este capítulo se recurren a poderosas técnicas de caracterización física como el microscopio electrónico de barrido, el microscopio de fuerzas atómicas o la espectrometría de dispersión de energía de rayos X. A su vez, se realiza un estudio sobre los efectos de la conmutación resistiva en los cambios inducidos en los dispositivos. En el siguiente capítulo, utilizando las estructuras MIS basadas en HfO2/Al2O3, se realiza un análisis de la estadística de la ruptura dieléctrica dependiente del tiempo, así como de los eventos de ruptura sucesivos. Utilizando un gran arsenal de modelos y técnicas estadísticas, se consigue reproducir las tendencias experimentales las cuales no son reproducibles con el modelo de Weibull, indicación de una ruptura dieléctrica no homogénea. A su vez, se proporciona una hipótesis que permite explicar el comportamiento observado. Seguidamente, en el último capítulo experimental, se realiza un análisis exhaustivo y extenso de la estadística espacial de los eventos de ruptura a través de los dispositivos MIM basados en HfO2. Utilizando estas técnicas, se consigue evaluar la correlación entre los eventos de ruptura, así como la que hay entre la localización y el tamaño de los eventos. Finalmente, en el capítulo conclusivo se presentan tanto las conclusiones más relevantes de la investigación realizada como una valoración de los posibles nuevos estudios que se originan de este trabajo.
In this doctoral thesis the dielectric breakdown (BD) phenomenon in metal-insulator-semiconductor (MIS) and metal-insulator-metal (MIM) structures based on HfO2 is investigated. More specifically, the analyzed devices are MIS/MIM devices with HfO2 as dielectric and MIS devices with a penta-nanolaminate as dielectric based on Al2O3/HfO2. Throughout the four long chapters that make up this thesis, plus a final conclusive chapter, an exhaustive study of the BD phenomenon has been carried out from completely different points of view. Starting with an introductory chapter to the BD, where the general aspects of this phenomenon are explained, each of the three subsequent experimental chapters revolve around an aspect of this phenomenon. In fact, in each chapter a different type of device is evaluated. Initially, the structural changes induced in the metal-insulator interface of the HfO2-based MIS devices due to the BD are analyzed. This is performed by using powerful physical characterization techniques such as the scanning electron microscope, the atomic force microscope and the energy dispersive X-ray spectroscopy. Moreover, the effects that resistive switching mechanism has on the physical changes induced in the devices after the BD are also evaluated. In the next chapter, the time dependent dielectric breakdown is analyzed in the MIS structures based on Al2O3/HfO2. Using different models and statistical techniques, the successive dielectric breakdown statistics of these devices is evaluated. In this case, the devices shown a non-homogenous time distribution i.e. it cannot be reproduced by the Weibull model. Then, in the last experimental chapter, the spatial statistics of the BD events is evaluated in MIM devices based on HfO2. Using the spatial statistic techniques and methods, it is possible to evaluate the correlation between the BD events, as well as the correlation between their location and their size. Finally, the concluding chapter presents the most relevant conclusions of this research as well as the possible new studies that originate from this work.
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Milligan, Alex Michael. "Application of Mid-Infrared Spectrometers in Determination and Quantification of Trans-fatty Acid Content in Snack Foods and Bakery Products." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1398786873.
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