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Journal articles on the topic 'MIB-1 staining'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Sandberg, David I., Mark A. Edgar, Lothar Resch, James T. Rutka, Lawrence E. Becker, and Mark M. Souweidane. "MIB-1 Staining Index of Pediatric Meningiomas." Neurosurgery 48, no. 3 (2001): 590–97. http://dx.doi.org/10.1097/00006123-200103000-00027.

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Nakasu, Satoshi, Dong Hou Li, Hidetoshi Okabe, Masayuki Nakajima, and Masayuki Matsuda. "Significance of MIB-1 Staining Indices in Meningiomas." American Journal of Surgical Pathology 25, no. 4 (2001): 472–78. http://dx.doi.org/10.1097/00000478-200104000-00006.

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3

Zelenetz, Andrew D., Craig Moskowitz, Jocelyn Maragulia, Carol S. Portlock, and Julie Teruya-Feldstein. "Sequential Chemotherapy Followed by High Dose Therapy and Autologous Stem Cell Rescue for Mantle Cell Lymphoma: Impact of MIB-1 on Outcome." Blood 112, no. 11 (2008): 3759. http://dx.doi.org/10.1182/blood.v112.11.3759.3759.

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Abstract Introduction: Optimal management of mantle cell lymphoma (MCL) remains undefined. However, recent data support the conclusion that upfront consolidation with high dose therapy with autologous stem cell rescue (HDT/ASCR) can improve the PFS (Dreyling, et al., 2005; Geisler, et al., 2008) and possibly OS (Geisler, et al. 2008). Based on gene expression profiling data, the proliferation signature has emerged as a critical determinant of prognosis in MCL (Rosenwald, et al., 2003). Immunohistochemical assessment of proliferation as estimated by MIB-1 (Ki-67) staining has been shown to pred

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Groisman, Gabriel M., Mary Amar, and Alona Meir. "Utility of MIB-1 (Ki-67) in Evaluating Diminutive Colorectal Polyps With Cautery Artifact." Archives of Pathology & Laboratory Medicine 131, no. 7 (2007): 1089–93. http://dx.doi.org/10.5858/2007-131-1089-uomkie.

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Abstract Context.—Accurate interpretation of colorectal polyp histology is essential in the decision-making process during treatment and surveillance following polypectomies. However, interpretation of diminutive colorectal polyps removed by thermal electrocoagulation (hot biopsy technique) is often problematic as a result of cautery artifact. Objective.—To evaluated the usefulness of the proliferation marker MIB-1 (Ki-67) as an aid in the differential diagnosis of diminutive colorectal polyps with cautery artifact, as adenomatous and nonadenomatous polyps display different patterns of epithel

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Taniguchi, Katsumi, Toshihiko Wakabayashi, Tazuka Yoshida та ін. "Immunohistochemical staining of DNA topoisomerase IIα in human gliomas". Journal of Neurosurgery 91, № 3 (1999): 477–82. http://dx.doi.org/10.3171/jns.1999.91.3.0477.

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Object. The enzyme DNA topoisomerase IIα (Topo IIα) was tested as a measure of cell proliferation in gliomas.Methods. Immunostaining for the Topo IIα and for the Ki-67 antigen (MIB-1 antibody) was performed in paraffin-embedded tissue sections obtained from 25 resected human gliomas. Additionally, cultured human glioma cells were subjected to simultaneous flow cytometry to determine Topo IIα and DNA content.Using flow cytometric analysis, the authors found that the Topo IIα antibody labeled cells in the S, G2, and M phases of the cell cycle and also those in some parts of the G0 and G1 phases.

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Ide, Mitsunobu, Minoru Jimbo, Masaaki Yamamoto, Yutaka Umebara, Shinji Hagiwara, and Osami Kubo. "MIB-1 staining index and peritumoral brain edema of meningiomas." Cancer 78, no. 1 (1996): 133–43. http://dx.doi.org/10.1002/(sici)1097-0142(19960701)78:1<133::aid-cncr19>3.0.co;2-0.

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KITAGAWA, Y., H. ITO, M. YOKOYAMA, T. SAWAIZUMI, and S. MAEDA. "The Effect of Cellular Proliferative Activity on Recurrence and Local Tumour Extent of Localized Giant Cell Tumour of Tendon Sheath." Journal of Hand Surgery 29, no. 6 (2004): 604–7. http://dx.doi.org/10.1016/j.jhsb.2004.06.012.

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This study investigates whether the proliferative activity of giant cell tumour of tendon sheath is related to its recurrence rate and local aggressiveness. The clinicopathological and immunohistochemical features of 30 localized giant cell tumours of tendon sheath were studied and the influence of the MIB-1 staining index on recurrence, tumour extent around the phalanx and involvement of the bone were evaluated. No significant difference in the MIB-1 staining index was found between the lesions which recurred and those which did not. Also there was no significant association between local agg

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Jütting, Uta, Peter Gais, Karsten Rodenacker, Joachim Böhm, and Heinz Höfler. "MIB-1, AgNOR AND DNA DISTRIBUTION PARAMETERS AND THEIR PROGNOSTIC VALUE IN NEUROENDOCRINE TUMOURS OF THE LUNG." Image Analysis & Stereology 19, no. 1 (2011): 39. http://dx.doi.org/10.5566/ias.v19.p39-43.

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One of the most important questions in clinical routine is to find out patients with good or worse prognosis to apply an optimal therapy scheme for each patient. In this study 58 patients with different neuroendocrine tumours of the lung were investigated. Histological sections were prepared with different stainings (MIB-1, AgNOR, Feulgen). By means of high resolution image cytometry stereological parameters were derived which are indicators for proliferation, ploidy and kinetics of the tumours. Cox regression analysis was calculated to test the significance of the parameters with regard to pr

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Boon, Mathilde E., Astrid Vinkestein, Annette van Binsbergen-Ingelse, and Caroline van Haaften. "Significance of MiB-1 staining in smears with atypical glandular cells." Diagnostic Cytopathology 31, no. 2 (2004): 77–82. http://dx.doi.org/10.1002/dc.20043.

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10

Hoshi, Michio, Kazunari Yoshida, Kenji Shimazaki, Hikaru Sasaki, Mitsuhiro Otani, and Takeshi Kawase. "Correlation between MIB-1 staining indices and recurrence in low-grade astrocytomas." Brain Tumor Pathology 14, no. 1 (1997): 47–51. http://dx.doi.org/10.1007/bf02478868.

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11

Verma, Kavita, Satya Raj Negi, and Sanjay Garhwal. "To study histopathological features, GFAP staining and Ki 67/ MIB-1 labelling index in diagnoses and histological grading of gliomas." Indian Journal of Forensic and Community Medicine 8, no. 2 (2021): 115–19. http://dx.doi.org/10.18231/j.ijfcm.2021.023.

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: A group of tumors that develops in the brain and spinal cord is called glioma. Histologically gliomas are classified into astrocytoma, ependymoma, oligodendroglioma, brain stem glioma and oligoastrocytoma. The present study was conducted to study histological grading of gliomas and correlate it with patient’s age, sex, GFAP staining, role of the Ki-67/MIB-1 labelling indices (PIs). The present retrospective study was conducted on 50 biopsies received. All specimens were subjected to immunohistochemistory for GFAP and MIB-1 and correlated with WHO grading for glioma.: High incidence of glial

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12

NAKASU, Satoshi, Masayuki NAKAJIMA, and Joji HANDA. "The Difference of MIB-1 Staining Indices in Meningiomas by a Counting Method." Japanese Journal of Neurosurgery 7, no. 5 (1998): 279–83. http://dx.doi.org/10.7887/jcns.7.279.

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13

Tomobe, Mitsuro, Toru Shimazui, Katsunori Uchida, and Hideyuki Akaza. "AgNOR Count in Resting Cells (Resting NOR) Is a New Prognostic Marker in Invasive Bladder Tumor." Analytical Cellular Pathology 22, no. 4 (2001): 193–99. http://dx.doi.org/10.1155/2001/689480.

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Purpose: We have previously demonstrated that the AgNOR count in proliferating cells is a predictor of tumor recurrence in superficial bladder tumor (J. Urol. 162 (1999), 63–68). In the present study, we evaluate the type of AgNOR associated with cell cycles as a prognostic factor in invasive bladder tumor using a double staining technique employing both AgNOR and MIB-1 labelling.Materials and methods: Forty-four paraffin sections of invasive bladder tumors were stained simultaneously with AgNOR and MIB-1. The number of AgNORs in proliferating (MIB-1 positive) or resting (MIB-1 negative) cells

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14

Mathilde E. Boon. "MICROWAVE-ANTIGEN RETRIEVAL: THE IMPORTANCE OF PH OF THE RETRIEVAL SOLUTION FOR MIB-1 STAINING." European Journal of Morphology 34, no. 5 (1996): 375–79. http://dx.doi.org/10.1076/ejom.34.5.0375.

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15

Boon, M. E. "Microwave-antigen retrieval: The importance of pH of the retrieval solution for MiB-1 staining." European Journal of Morphology 34, no. 5 (1996): 375–80. http://dx.doi.org/10.1076/ejom.34.5.375.13053.

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16

Tiwari, Kavita, Harendra Kumar, Garima Dundy, Prashant Singh, and Alok Kumar Gupta. "Histomorphological spectrum of meningeal tumours and its association with MIB-1 labelling index." International Journal of Research in Medical Sciences 11, no. 8 (2023): 2894–900. http://dx.doi.org/10.18203/2320-6012.ijrms20232419.

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Background: Meningiomas are extremely common, slow growing tumours originating from meningeal covering of brain and spinal cord. They are mostly encountered in middle or later adult life. Females are affected more commonly than males. Grading of meningiomas based on histological features has certain limitations in predicting exact biological behavior hence ancillary studies like immunohistochemistry can be used to predict the nature of the lesion. Methods: This prospective cross-sectional study was conducted in pathology department in our institute. Total 105 cases, diagnosed as meningioma bet

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17

Karsy, Michael, Brian Burnett, Antonio Di Ieva, Michael D. Cusimano, and Randy L. Jensen. "Microvascularization of Grade I meningiomas: effect on tumor volume, blood loss, and patient outcome." Journal of Neurosurgery 128, no. 3 (2018): 657–66. http://dx.doi.org/10.3171/2016.10.jns161825.

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OBJECTIVEQuantitative assessment of tumor microvascularity has the potential to improve prognostication, advance understanding of tumor biology, and help narrow potential molecular therapies. While the role of tumor microvascularity has been widely studied in meningiomas, this study examines both the role of automated measurements and the impact on surgical outcome.METHODSTwo hundred seven patients with Grade I meningiomas underwent surgery between 1996 and 2011. Tissue samples from each patient were retrospectively evaluated for histopathological measures of microvascularity, including staini

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18

Haddad, Alexander, Jacob Young, Ishan Kanungo, et al. "PATH-37. IDENTIFYING HIGH-RISK PATIENTS FOR WHO GRADE I MENINGIOMA RECURRENCE USING HISTOPATHOLOGICAL FEATURES AND THE MIB-1 INDEX." Neuro-Oncology 22, Supplement_2 (2020): ii172. http://dx.doi.org/10.1093/neuonc/noaa215.718.

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Abstract BACKGROUND In this study, we identify clinical, radiographic, and histopathologic prognosticators of overall, early, and post-median recurrence in World Health Organization (WHO) grade I meningiomas. We also determine a clinically relevant cutoff for MIB-1 to identify patients at high risk for recurrence. METHODS A retrospective review of WHO grade I meningioma patients with available MIB-1 index data who underwent treatment at our institution from 2007-2017 was performed. Univariate and multivariate analyses, and recursive partitioning analysis (RPA), were used to identify risk facto

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Miyashita, Katsuyoshi, Yutaka Hayashi, Hironori Fujisawa, Mitsuhiro Hasegawa, and Junkoh Yamashita. "Recurrent intracranial solitary fibrous tumor with cerebrospinal fluid dissemination." Journal of Neurosurgery 101, no. 6 (2004): 1045–48. http://dx.doi.org/10.3171/jns.2004.101.6.1045.

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✓ Solitary fibrous tumor (SFT) is a benign and rare neoplasm. To date, only 37 patients with intracranial SFTs have been reported. Although a number of the tumors were recurrent and some later underwent malignant transformation, none of these lesions progressed to cerebrospinal fluid (CSF) dissemination. In this paper the authors report a case of SFT in which the lesion recurred several times and ultimately was disseminated by the CSF. The patient was a 63-year-old woman with multiple intracranial and spinal tumors. Fifteen years before this presentation, at the age of 48 she had been hospital

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20

De Braud, Filippo G., Sara Pusceddu, Massimo Milione, et al. "Loss of succinate dehydrogenase (SDHB) in midgut carcinoids as a prognostic factor: A new marker of personalized cancer medicine in neuroendocrine tumors?" Journal of Clinical Oncology 31, no. 4_suppl (2013): 186. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.186.

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186 Background: Gene mutations of the succinate dehydrogenase (SDH) complex have recently been involved in the pathogenesis of cancer cells. These mutations often are associated with SDH subunity B loss of activity and overexpression of HIF-1α. The immunoistochemical (IHC) loss of SDHB expression has recently been reported to be a surrogate marker of malignancy in pheocromocytomas and paragangliomas. The aim is the evaluation of SDHB levels expression in advanced midgut carcinoids and investigate its potential role as prognostic marker. Methods: 31 advanced midgut carcinoids were treated in ou

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21

Hirokawa, Mitsuyoshi, and J. Aidan Carney. "Cell Membrane and Cytoplasmic Staining for MIB-1 in Hyalinizing Trabecular Adenoma of the Thyroid Gland." American Journal of Surgical Pathology 24, no. 4 (2000): 575–78. http://dx.doi.org/10.1097/00000478-200004000-00013.

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22

Prayson, Richard A., James T. McMahon, and Gene H. Barnett. "Solitary fibrous tumor of the meninges." Journal of Neurosurgery 86, no. 6 (1997): 1049–52. http://dx.doi.org/10.3171/jns.1997.86.6.1049.

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✓ The authors present the case of a left frontal solitary fibrous tumor of the meninges. The gross appearance of the tumor was very similar to that of a fibroblastic meningioma. Histological examination showed a mixture of spindle-shaped and round cells arranged in a collagen matrix. Immunohistochemical staining of the tumor demonstrated diffuse positive staining for CD34 and vimentin. The tumor displayed no positive staining for markers of muscle, epithelial, glial, or neurocrest differentiation or for estrogen and progesterone receptors. The MIB-1 labeling index (the percentage of positive s

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23

La Corte, Emanuele, Michele Dei Cas, Alberto Raggi, et al. "Long and Very-Long-Chain Ceramides Correlate with A More Aggressive Behavior in Skull Base Chordoma Patients." International Journal of Molecular Sciences 20, no. 18 (2019): 4480. http://dx.doi.org/10.3390/ijms20184480.

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Background: Skull base chordomas are rare tumors arising from notochord. Sphingolipids analysis is a promising approach in molecular oncology, and it has never been applied in chordomas. Our aim is to investigate chordoma behavior and the role of ceramides. Methods: Ceramides were extracted and evaluated by liquid chromatography and mass spectrometry in a cohort of patients with a skull base chordoma. Clinical data were also collected and correlated with ceramide levels. Linear regression and correlation analyses were conducted. Results: Analyzing the association between ceramides level and MI

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Andreas, Kiriakopoulos, Poulios Efthimios, Giannopoulos Georgios, and Linos Dimitrios. "Thyroid Hyalinizing Trabecular Tumor: A Case Series." International Journal of Medical and Pharmaceutical Case Reports 9, no. 1 (2017): 1–4. https://doi.org/10.9734/IJMPCR/2017/33912.

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<strong>Aim:</strong> Hyalinizing Trabecular Tumor (HTT) of the thyroid gland is an unusual and rare follicular derived neoplasm, which was first described from Carney and colleagues in 1987. We aim to present two cases of HTT diagnosed as papillary thyroid carcinomas in preoperative FNA cytological findings, although the postoperative histological examinations revealed the presence of Hyalinizing Trabecular tumors. Moreover, a short review regarding the diagnostic and clinical aspects of this rare thyroid tumor is also presented. <strong>Cases Presentation:</strong> A 30 year old and a 33 yea

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KATOH, R. "Growth activity in hyperplastic and neoplastic human thyroid determined by an immunohistochemical staining procedure using monoclonal antibody MIB-1*1." Human Pathology 26, no. 2 (1995): 139–46. http://dx.doi.org/10.1016/0046-8177(95)90029-2.

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26

Green, MD, Ileana, Oscar Lin, MD, PhD, Semra Olgac, MD, Maureen F. Zakowski, MD, and David S. Klimstra, MD. "Immunohistochemical Staining of Cytologic Smears With MIB-1 Helps Distinguish Low-Grade From High-Grade Neuroendocrine Neoplasms." American Journal of Clinical Pathology 120, no. 2 (2003): 209–16. http://dx.doi.org/10.1309/tgcd-66l3-1dhy-x5hk.

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Lin, Oscar, Semra Olgac, Ileana Green, Maureen F. Zakowski, and David S. Klimstra. "Immunohistochemical Staining of Cytologic Smears With MIB-1 Helps Distinguish Low-Grade From High-Grade Neuroendocrine Neoplasms." American Journal of Clinical Pathology 120, no. 2 (2003): 209–16. http://dx.doi.org/10.1309/tgcd66l31dhyx5hk.

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Hattori, H. "Sclerosing haemangioma of the lung is positive for MIB-1 in cell membrane and cytoplasmic staining pattern." Histopathology 40, no. 3 (2002): 291–93. http://dx.doi.org/10.1046/j.1365-2559.2002.01330.x.

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OKADA, K., J. NISHIDA, T. MORITA, H. KAKIZAKI, A. ISHIKAWA, and T. HOTTA. "Low-grade intraosseous osteosarcoma in Northern Japan: Advantage of AgNOR and MIB-1 staining in differential diagnosis." Human Pathology 31, no. 6 (2000): 633–39. http://dx.doi.org/10.1053/hupa.2000.8231.

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Schmidt, Mirko H., Rainer Broll, Hans-Peter Bruch, and Michael Duchrow. "The proliferation marker pKi-67 becomes masked to MIB-1 staining after expression of its tandem repeats." Histochemistry and Cell Biology 118, no. 5 (2002): 415–22. http://dx.doi.org/10.1007/s00418-002-0464-5.

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Schiffer, D., A. Dutto, P. Cavalla, et al. "Prognostic Factors in Oligodendroglioma." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 24, no. 04 (1997): 313–19. http://dx.doi.org/10.1017/s0317167100032984.

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ABSTRACT:Background:A reliable marker for tumor oligodendroglial cells is not yet available, so that the histological recognition of the tumor still encounters uncertainties. There is no general agreement also on prognostic factors in oligodendroglioma. The inconsistency concerns mainly the histopathological factors. The aim of the study was recognition of prognostic factors in oligodendroglioma.Methods:In a series of ninety-eight oligodendrogliomas, including twenty mixed oligoastrocytomas, clinical [sex, age at surgery, tumor location, symptoms at presentation], therapeutic [extent of resect

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Langlois, Neil E. I., Sarah Tarran, and Peter Dziewulski. "A Study of Burns for Wound Ageing reveals Changes in Unburnt Skin with Implications for Future Research." Medicine, Science and the Law 45, no. 3 (2005): 205–10. http://dx.doi.org/10.1258/rsmmsl.45.3.205.

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Thirty-three punch biopsy sets of burn wound edge and adjacent unburnt skin from burn wounds aged six hours to 23 days were obtained from 18 patients. Immunohistochemical staining was performed for transforming growth factor beta receptor, epidermal growth factor receptor and MIB-1 (which stains the cell cycle associated antigen ki-67) in addition to integrins alpha V, 5 and 3 to assess for temporal patterns that might assist in the ageing of burn wounds. There was an early (12 hr-4 day) rise in integrin alpha V expression, an increasing expression of transforming growth factor beta receptor f

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Zada, Gabriel, Whitney W. Woodmansee, Shakti Ramkissoon, Jordan Amadio, Vania Nose, and Edward R. Laws. "Atypical pituitary adenomas: incidence, clinical characteristics, and implications." Journal of Neurosurgery 114, no. 2 (2011): 336–44. http://dx.doi.org/10.3171/2010.8.jns10290.

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Object The 2004 WHO classification of pituitary adenomas now includes an “atypical” variant, defined as follows: MIB-1 proliferative index greater than 3%, excessive p53 immunoreactivity, and increased mitotic activity. The authors review the incidence of this atypical histopathological subtype and its correlation with tumor subtype, invasion, and surgical features. Methods The records of 121 consecutive patients who underwent transsphenoidal surgery for pituitary adenomas during an 18-month period were retrospectively reviewed for evidence of atypical adenomas. Results Eighteen adenomas (15%)

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Sure, Ulrich, Nick Butz, Jürgen Schlegel, et al. "Endothelial proliferation, neoangiogenesis, and potential de novo generation of cerebrovascular malformations." Journal of Neurosurgery 94, no. 6 (2001): 972–77. http://dx.doi.org/10.3171/jns.2001.94.6.0972.

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Object. To date, both arteriovenous malformations (AVMs) and cavernomas have been considered to be congenital malformations. A recent survey of the literature has shown the potential for de novo generation of both familial and sporadic cavernomas as well as AVMs. Therefore, it was of interest to determine the biological behavior of these lesions in detail. Methods. The proliferative and angiogenic capacities of the endothelium of 13 cavernomas and 25 AVMs obtained in patients recently treated (1997–1998) at one institution were studied. Immunohistochemical staining for proliferating cell nucle

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Prayson, Richard A., and John H. Suh. "Subependymomas." Archives of Pathology & Laboratory Medicine 123, no. 4 (1999): 306–9. http://dx.doi.org/10.5858/1999-123-0306-s.

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Abstract Background.—Subependymomas are uncommonly encountered ependymal tumors, which are important to distinguish from ordinary ependymomas because of their generally better prognosis. Objective.—To review the clinicopathologic features and MIB-1 labeling indices (marker of cell proliferation) of 14 subependymomas. Design.—Retrospective review of 14 subependymomas encountered in a tertiary care setting. Results.—Fourteen ependymomas presenting in 8 men and 6 women between the ages of 18 and 78 years (mean, 53.6 years) comprise the study group. The most common clinical presentations included

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Leonardi, Elena, Paolo Dalla Palma, Alessandro Reich, Orazio Caffo, and Lucio Luciani. "Biological Characterisation of Superficial Bladder Cancer by Bivariate Cytokeratin 7/DNA Analysis, Flow Cytometric Assessment of MIB-1, and an Immunohistochemical Study." Analytical Cellular Pathology 21, no. 1 (2000): 21–33. http://dx.doi.org/10.1155/2000/672354.

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A total of 238 cases of bladder carcinoma stages Ta, Tis, T1 were submitted prospectively to multiparameter flow cytometry and immunohistochemical study in order to determine the biological aggressiveness of the tumour. DNA index (DI), S-phase fraction (SPF) obtained by bivariate cytokeratin 7=DNA analyses, and the immunohistochemical evaluation of p53 and MIB-1 were studied in relation to the traditional prognostic factors in bladder cancer (stage and grade). The variance analysis results showed that DNA aneuploidy was significantly associated with high stage (p= 0:0001), high grade (p= 0:000

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Montes-Mojarro, Ivonne A., Saki Hassas, Sina Staehle, et al. "Multiparametric Classification of Non-Muscle Invasive Papillary Urothelial Neoplasms: Combining Morphological, Phenotypical, and Molecular Features for Improved Risk Stratification." International Journal of Molecular Sciences 23, no. 15 (2022): 8133. http://dx.doi.org/10.3390/ijms23158133.

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Diagnosis and grading of non-invasive papillary urothelial tumors according to the current WHO classification poses some challenges for pathologists. The diagnostic reproducibility of separating low-grade and high-grade lesions is low, which impacts their clinical management. Whereas papillary urothelial neoplasms with low malignant potential (PUN-LMP) and low-grade papillary non-invasive carcinoma (LG-PUC) are comparable and show frequent local recurrence but rarely metastasize, high-grade papillary non-invasive carcinoma (HG-PUC) has a poor prognosis. The main objective of this work is to de

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Matsuno, Akira, Tadashi Nagashima, Reiko Matsuura, et al. "Correlation Between MIB-1 Staining Index and the Immunoreactivity of p53 Protein in Recurrent and Non-recurrent Meningiomas." American Journal of Clinical Pathology 106, no. 6 (1996): 776–81. http://dx.doi.org/10.1093/ajcp/106.6.776.

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JEMEC, B., A. O. GROBBELAAR, G. D. WILSON, P. J. SMITH, R. SANDERS, and D. A. McGROUTHER. "Is Dupuytren’s Disease Caused by an Imbalance between Proliferation and Cell Death?" Journal of Hand Surgery 24, no. 5 (1999): 511–14. http://dx.doi.org/10.1054/jhsb.1999.0251.

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Dupuytren’s contracture shares certain properties with malignant tumours, characterized by proliferation and lack of apoptosis, which may be induced by the c- myc oncogene. Because of these similarities, the relationship between the c- myc oncogene expression, bcl-2 oncogene (antiapoptotic gene) and proliferation was investigated in Dupuytren’s disease. Proliferation was assessed by immunohistochemical staining of the mib-1 antibody. Results were compared with those from fibrosarcoma specimens, representing a related malignant tumour. Non-diseased fascia from Dupuytren patients and flexor reti

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Ohba, Shigeo, Hikaru Sasaki, Tokuhiro Kimura, Eiji Ikeda, and Takeshi Kawase. "Clear Cell Meningiomas." Neurosurgery 67, no. 3 (2010): E870—E871. http://dx.doi.org/10.1227/01.neu.0000374857.06732.cd.

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Abstract BACKGROUND AND IMPORTANCE Intracranial clear cell meningioma is very rare. We present 3 cases of intracranial clear cell meningiomas genetically characterized by comparative genomic hybridization with a review of the literature. CLINICAL PRESENTATION Patient 1 is a 38-year-old woman with a petroclival tumor. Patient 2 is a 60-year-old man with a tumor at the foramen magnum. Patient 3 is a 60-year-old man with a tumor at the posterior clinoid process. Gross total resection was performed in patients 1 and 2. Patient 1 has been free from recurrence for 10 years. Patient 2 had a tumor rec

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Schaffel, R., C. Hedvat, J. Teruya-Feldstein, C. S. Portlock, C. H. Moskowitz, and A. D. Zelenetz. "Prognostic value of quantitative image analysis (QIA) for determination of proliferative index in mantle cell lymphoma (MCL) treated with sequential chemotherapy followed by high-dose therapy and autologous stem cell rescue (HDT/ASCR)." Journal of Clinical Oncology 27, no. 15_suppl (2009): e19522-e19522. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e19522.

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e19522 Background: Gene expression studies have demonstrated that the proliferation signature is the most important factor in determination of outcome in MCL. However, visual assessment of immunohistochemical staining is not standardized. QIA of MIB-1/Ki67 staining may have a greater reliability for determination of the PI. We tested the agreement between manual counting (MC) and QIA and its prognostic value in patients with MCL. Methods: 105 patients with MCL underwent therapy for de novo MCL, of these, 66 had slides stained with MIB-1 for the analysis. The PI was determined in three ways: 1)

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Hung, Kuo-Sheng, and Shen-Long Howng. "Prognostic significance of annexin VII expression in glioblastomas multiforme in humans." Journal of Neurosurgery 99, no. 5 (2003): 886–92. http://dx.doi.org/10.3171/jns.2003.99.5.0886.

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Object. Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults. It is nearly uniformly fatal, with a median survival time of approximately 1 year, despite modern treatment modalities. Nevertheless, a range of survival times exists around this median. Efforts to understand why some patients live longer or shorter than the average may provide insight into the biology of these neoplasms. The annexin VII (ANX7) gene is located on the human chromosome 10q21, a site long hypothesized to harbor tumor suppressor genes associated with prostate and other cancers. To te

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Shiino, Akihiko, Satoshi Nakasu, Masayuki Matsuda, Jyoji Handa, Shigehiro Morikawa, and Toshiro Inubushi. "Noninvasive evaluation of the malignant potential of intracranial meningiomas performed using proton magnetic resonance spectroscopy." Journal of Neurosurgery 91, no. 6 (1999): 928–34. http://dx.doi.org/10.3171/jns.1999.91.6.0928.

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Object. Controversy exists about correlations between histological tumor grade and magnetic resonance (MR) spectroscopy data. The authors studied single-voxel proton MR spectroscopy as a noninvasive way to evaluate grade of malignancy in intracranial meningiomas.Methods. The authors compared the results of MR spectroscopy with those derived by the MIB-1 staining index (SI) in 29 meningiomas. Proton MR spectroscopy was performed using stimulated echo acquisition and volume-localized solvent-attenuated proton nuclear MR sequences before surgery or other therapy.Twenty-four tumors were histologic

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Kim, Min Soo, Kyu Hong Kim, Eun Hee Lee, et al. "Results of immunohistochemical staining for cell cycle regulators predict the recurrence of atypical meningiomas." Journal of Neurosurgery 121, no. 5 (2014): 1189–200. http://dx.doi.org/10.3171/2014.7.jns132661.

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Object The aim of this study was to evaluate the role of certain cell-cycle regulatory proteins in the recurrence of atypical meningiomas. These proteins were analyzed with immunohistochemical staining to identify predisposing factors for the recurrence of atypical meningiomas. Methods The authors retrospectively reviewed the medical records of patients with atypical meningiomas diagnosed in the period from January 2000 to June 2012 at the Department of Neurosurgery at Samsung Changwon Hospital and Dong-A University Medical Center. Clinical data included patient sex and age at the time of surg

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Asano, Kenichiro, Tetsuji Takeda, Takahiro Nakano, and Hiroki Ohkuma. "Correlation of MIB-1 staining index and 201Tl-SPECT retention index in preoperative evaluation of malignancy of brain tumors." Brain Tumor Pathology 27, no. 1 (2010): 1–6. http://dx.doi.org/10.1007/s10014-009-0257-9.

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Schmidt, Mirko H. H., Rainer Broll, Hans-Peter Bruch, and Michael Duchrow. "Correction to: The proliferation marker pKi-67 becomes masked to MIB-1 staining after expression of its tandem repeats." Histochemistry and Cell Biology 151, no. 3 (2018): 275. http://dx.doi.org/10.1007/s00418-018-1755-9.

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Wells, Stephen J., Patricia B. DeRose, and Cynthia Cohen. "Image cytometric comparison of proliferating cell nuclear antigen and MIB-1 staining in hepatocellular carcinoma and adjacent liver tissue." Cytometry 26, no. 3 (1996): 198–203. http://dx.doi.org/10.1002/(sici)1097-0320(19960915)26:3<198::aid-cyto3>3.0.co;2-b.

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Bonds, Lian, Paige Baker, Carol Gup, and Kenneth R. Shroyer. "Immunohistochemical Localization of Cdc6 in Squamous and Glandular Neoplasia of the Uterine Cervix." Archives of Pathology & Laboratory Medicine 126, no. 10 (2002): 1164–68. http://dx.doi.org/10.5858/2002-126-1164-ilocis.

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Abstract Context.—Cdc6 has been extensively studied as a marker for cellular proliferation that is expressed during the normal cell cycle. Recent studies indicate that Cdc6 may be a marker for cervical intraepithelial neoplasia (CIN) and carcinoma; however, the histologic distribution of Cdc6 has not been explicitly defined. Expression of Cdc6 in the endocervical mucosa also remains unexplored. Objective.—The goal of the current study was to evaluate the distribution of Cdc6 protein, MIB-1 protein, and human papillomavirus (HPV) DNA in a broad range of cervical tissues, including normal, poten

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Gaffey, Thomas A., Bernd W. Scheithauer, Ricardo V. Lloyd, et al. "Corticotroph carcinoma of the pituitary: a clinicopathological study." Journal of Neurosurgery 96, no. 2 (2002): 352–60. http://dx.doi.org/10.3171/jns.2002.96.2.0352.

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✓ To understand the relationship between pituitary adenoma and carcinoma, four adrenocorticotropic hormone—producing pituitary adenomas and corresponding metastatic carcinomas were studied. All were functional macroadenomas (three cases of Nelson syndrome and one of Cushing disease) that initially invaded the sella turcica and occurred in women ranging in age from 17 to 66 years (mean 45 years). Metastases (two craniospinal and two systemic) occurred after latency periods of 6 to 13 years. Histological specimens were immunostained for pituitary hormones, Ki-67 antigen (MIB-1), p53 and p27 prot

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Klamminger, Gilbert Georg, Elke Eltze, Annick Bitterlich, et al. "Ki-67 as a Prognostic Marker in Squamous Cell Carcinomas of the Vulva: A Systematic Review." Journal of Clinical Medicine 14, no. 6 (2025): 2045. https://doi.org/10.3390/jcm14062045.

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Background/Objectives: To evaluate the prognostic impact of immunohistochemical ki-67 staining analysis regarding lymph node involvement and survival data (overall/progression-free survival) in squamous cell carcinoma of the vulva. Methods: A systematic literature search of English and German articles was conducted (PubMed, Embase, Scopus, Web of Science) from 1980 to December 2023, including the search terms “vulvar Neoplasms”, “vulvar cancer”, “vulvar carcinoma”, “vulvar tumor”, ”vulvar tumour”, “vulvar malignancy”, “vulvar malignant”, “ki-67”, “MIB-1”, “MIB1”, “proliferative index”, “prolif

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