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Journal articles on the topic 'Mice as laboratory animals'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2024

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1

Joyner, C. P., L. C. Myrick, J. P. Crossland, and W. D. Dawson. "Deer Mice As Laboratory Animals." ILAR Journal 39, no. 4 (January 1, 1998): 322–30. http://dx.doi.org/10.1093/ilar.39.4.322.

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2

Birke, Lynda. "Who—or What—are the Rats (and Mice) in the Laboratory." Society & Animals 11, no. 3 (2003): 207–24. http://dx.doi.org/10.1163/156853003322773023.

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AbstractThis paper explores the many meanings attached to the designation,"the rodent in the laboratory" (rat or mouse). Generations of selective breeding have created these rodents. They now differ markedly from their wild progenitors, nonhuman animals associated with carrying all kinds of diseases.Through selective breeding, they have moved from the rats of the sewers to become standardized laboratory tools and (metaphorically) saviors of humans in the fight against disease. This paper sketches two intertwined strands of metaphors associated with laboratory rodents.The first focuses on the i

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3

Hobbiesiefken, Ute, Paul Mieske, Lars Lewejohann, and Kai Diederich. "Evaluation of different types of enrichment - their usage and effect on home cage behavior in female mice." PLOS ONE 16, no. 12 (December 23, 2021): e0261876. http://dx.doi.org/10.1371/journal.pone.0261876.

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Numerous studies ascertained positive effects of enriched environments on the well-being of laboratory animals including behavioral, physiological and neurochemical parameters. Conversely, such conclusions imply impaired animal welfare and health in barren husbandry conditions. Moreover, inappropriate housing of laboratory animals may deteriorate the quality of scientific data. Recommendations for housing laboratory animals stipulate that cages should be enriched to mitigate adverse effects of barren housing. In this context, it is not only unclear what exactly is meant by enrichment, but also

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4

Miranda, Alice, José M. Pêgo, and Jorge Correia-Pinto. "Animal facility videoendoscopic intubation station: tips and tricks from mice to rabbits." Laboratory Animals 51, no. 2 (July 9, 2016): 204–7. http://dx.doi.org/10.1177/0023677216652342.

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Endotracheal intubation of laboratory animals is a common procedure shared by several research fields for different purposes, such as mechanical ventilation of anaesthetized animals, instillation of cytotoxic nanoparticles, infectious agents or tumour cells for induction of disease models, and even for diagnostic and therapeutic purposes. These different research purposes, achieved in different animal models, require technical expertise and equipment that suits every research need from animal facilities. In this short report we propose a videoendoscopic intubation station that could be shared

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5

Bondarchuk, A. O., A. P. Paliy, and M. Ye Blazheyevskiy. "Determination of acute toxicity of the ‘Bondarmin’ disinfectant." Journal for Veterinary Medicine, Biotechnology and Biosafety 5, no. 2 (June 24, 2019): 26–30. http://dx.doi.org/10.36016/jvmbbs-2019-5-2-5.

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In the article the results of the study of toxic effect of the designed disinfectant (active ingredient potassium peroxomonosulfate) on laboratory animals (mice) are presented. For the recent years a variety of scientific works both by domestic and by foreign scientists has been devoted to the study of different disinfectants’ toxicity. However today there is a number of issues that require more detailed studying and scientific justification. Among them the problem of toxic effects of disinfectants on the animal organism occupies a special place. The aim of our work was to study the toxic effe

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6

Zechner, Dietmar, Benjamin Schulz, Guanglin Tang, Ahmed Abdelrahman, Simone Kumstel, Nico Seume, Rupert Palme, and Brigitte Vollmar. "Generalizability, Robustness and Replicability When Evaluating Wellbeing of Laboratory Mice with Various Methods." Animals 12, no. 21 (October 25, 2022): 2927. http://dx.doi.org/10.3390/ani12212927.

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An essential basis for objectively improving the status of animals during in vivo research is the ability to measure the wellbeing of animals in a reliable and scientific manner. Several non-invasive methods such as assessing body weight, burrowing activity, nesting behavior, a distress score and fecal corticosterone metabolites were evaluated in healthy mice and after three surgical interventions or during the progression of four gastrointestinal diseases. The performance of each method in differentiating between healthy and diseased animals was assessed using receiver operating characteristi

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7

Ibrahim, S. A. M., and F. Nowell. "Transfer ofEimeria apionodesfrom wood mice (Apodemus sylvaticus) to laboratory mice (Mus musculus)." Parasitology 103, no. 2 (October 1991): 179–83. http://dx.doi.org/10.1017/s003118200005945x.

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Transfer ofEimeria apionodesfrom wood mice directly into untreated laboratory mice was unsuccessful but transfer into corticosteroid-treated animals produced an oocyst output, about 1000 times less than that observed from wood mice after a similar inoculum. Repeated passage through corticosteroid-treated laboratory mice resulted in a line adapted to survival in untreated animals. This line was compared with the parent strain maintained in wood mice and some features of the oocyst output patterns, notably the pre-patent period, appeared to be controlled by the host species. The oocyst productio

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8

Friese, Carrie. "Intimate entanglements in the animal house: Caring for and about mice." Sociological Review 67, no. 2 (February 28, 2019): 287–98. http://dx.doi.org/10.1177/0038026119829753.

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This article presents two vignettes from ethnographic research conducted in a ‘biological services unit’ or mouse house at a life sciences research institute in the UK. I focus on the ‘intimate knowledge’ two animal technicians demonstrated as crucial to care for the mice, where affective knowledge operated alongside scientific knowledge of animal welfare and administrative knowledge of keeping laboratory animals. I then show how caring for and about laboratory mice entailed caring about various other things, things that could help improve the lives of the mice. I thematize how the animal tech

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9

Clarkson, Jasmine M., Matthew C. Leach, Paul A. Flecknell, and Candy Rowe. "Negative mood affects the expression of negative but not positive emotions in mice." Proceedings of the Royal Society B: Biological Sciences 287, no. 1933 (August 26, 2020): 20201636. http://dx.doi.org/10.1098/rspb.2020.1636.

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Whether and to what extent animals experience emotions is crucial for understanding their decisions and behaviour, and underpins a range of scientific fields, including animal behaviour, neuroscience, evolutionary biology and animal welfare science. However, research has predominantly focused on alleviating negative emotions in animals, with the expression of positive emotions left largely unexplored. Therefore, little is known about positive emotions in animals and how their expression is mediated. We used tail handling to induce a negative mood in laboratory mice and found that while being m

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10

Ujwala Ashokrao Jadhao, Chatraguna Eknathrao Lagad, and Rajesh Kundlikrao Ingole. "Laboratory animal handling techniques, basic facilities and care: A review." World Journal of Biology Pharmacy and Health Sciences 12, no. 3 (December 30, 2022): 170–82. http://dx.doi.org/10.30574/wjbphs.2022.12.3.0239.

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Animals have been utilized in pharmaceutical scientific research and development for more than 300 years. Pharmaceutical items are a must in order to treat illnesses caused by viruses, bacteria, or homeostatic imbalance, among other causes. Pharmaceuticals must be thoroughly characterized via in vitro, in vivo, and clinical trial investigations in order to be used in humans. It is essential to quantify organism's in vivo using animals whose physiology and genetics are most similar to those of humans. Common animals used for laboratory experimental research are Cats, Rats, Dogs, Mice, Guinea pi

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11

Malakoff, D. "LABORATORY ANIMALS: Researchers Fight Plan to Regulate Mice, Birds." Science 290, no. 5489 (October 6, 2000): 23a—23. http://dx.doi.org/10.1126/science.290.5489.23a.

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12

ABRAMOVICI, A., and M. WOLMAN. "Inbred Strains of Laboratory Animals: Superior to Outbred Mice?" JNCI Journal of the National Cancer Institute 87, no. 12 (June 21, 1995): 933. http://dx.doi.org/10.1093/jnci/87.12.933.

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13

Tallent, Bret R., L. Matthew Law, Rachel K. Rowe, and Jonathan Lifshitz. "Partial cage division significantly reduces aggressive behavior in male laboratory mice." Laboratory Animals 52, no. 4 (February 6, 2018): 384–93. http://dx.doi.org/10.1177/0023677217753464.

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Aggression in mice often results in injury leading to unplanned euthanasia or the initiation of protocols to isolate animals, thereby increasing research costs and straining resources. Here, we tested if adding a partial cage divider into existing mouse cages affected aggressive-like behavior in group-housed male mice (18 mice; 3 per cage). Mice were randomly assigned to one of two groups upon arrival to the vivarium: (1) standard cage; (2) cage with a partial cage divider. Behavioral observation over 12 hours were conducted at day one, two, and seven after receipt at the facility in order to

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14

Inoue, T., and H. Kobayashi. "Responses to orally ingested Neotyphodium endophyte toxins in laboratory animals." NZGA: Research and Practice Series 13 (January 1, 2007): 411–14. http://dx.doi.org/10.33584/rps.13.2006.3112.

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A series of experiment were conducted to examine the toxicities of Neotyphodium endophyte in laboratory animals. Groups of mice and hamsters were fed endophytic perennial ryegrass seeds. The hamsters presented ergotism-like symptoms while mice hardly indicated the toxicosis. Goups of mice and hamsters were fed endophytic perennial ryegrass seeds for 8 days and total excreta collections were made to evaluate apparent absorptions of endophytic alkaloids. Accumulations of endophyte toxins in the tissues and organs were also analysed. Although approximately 50% of lolitrem B and 90% of ergovaline

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15

Uysal, Murat, Serdar Savaş Gül, Serhat Karaman, Ufuk Tas, Hilal Irmak Sapmaz, Funda Uysal, Kursad Aytekin, and Mehmet Kemal Tümer. "Caecum location in laboratory rats and mice: an anatomical and radiological study." Laboratory Animals 51, no. 3 (July 4, 2016): 245–55. http://dx.doi.org/10.1177/0023677216658916.

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Intraperitoneal (i.p.) injection is the most frequently used method for implementing parenteral therapies in rats and mice. Whether the caecum is located in the right caudal quadrant or left caudal quadrant in the abdominal cavity is not clear. For that reason, we have developed a method for identifying the location of the caecum in rats and mice and thus revealed the most reliable location for i.p. injection in these animals. Two hundred Wistar albino rats and 100 BALB/c mice were used. The location of the caecum was determined by revealing the intra-abdominal organs immediately following eut

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16

Lewis, RS, and JL Hurst. "The assessment of bar chewing as an escape behaviour in laboratory mice." Animal Welfare 13, no. 1 (February 2004): 19–25. http://dx.doi.org/10.1017/s0962728600026610.

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AbstractThe ability to measure objectively how an animal perceives its home environment is essential for improving the housing and husbandry conditions of laboratory animals. Chewing at cage bars by a rodent may reflect the animal's desire to escape from its home cage and thus provide a measure of the relative aversiveness or inadequacy of different housing conditions from the animal's viewpoint. To assess whether bar chewing by laboratory mice is an escape behaviour, adult male and female ICR-(CD-1) mice were housed individually or in same-sex groups of three in modified shoebox-type cages. C

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17

Kashkovskaya, Lyudmila Mikhaylovna, Andrey Vladimirovich Balyshev, Vladimir Aleksandrovich Orobets, and Ivan Aleksandrovich Fedorov. "Toxicological characteristics of anticoccidial preparation Decvycox on laboratory animals." Agrarian Scientific Journal, no. 3 (March 16, 2020): 51–57. http://dx.doi.org/10.28983/asj.y2020i3pp51-57.

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The common practice in the prevention and treatment of eimeriosis in chickens is the application of anticoccidial preparations. The parameters of acute toxicity of the anticoccidial preparations Decvycox in laboratory animals were studied. It was found out that the LD50 of Decvycox with oral administration to mice and rats exceeds doses of 6579 and 7222 mg/kg of animal weight, respectively. Thus, according to the generally accepted hygienic classification, Decvycox belongs to hazard class 4 - low-hazard substances.

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18

Lewejohann, Lars, Kerstin Schwabe, Christine Häger, and Paulin Jirkof. "Impulse for animal welfare outside the experiment." Laboratory Animals 54, no. 2 (February 12, 2020): 150–58. http://dx.doi.org/10.1177/0023677219891754.

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Animal welfare is a growing societal concern and the well-being of animals used for experimental purposes is under particular scrutiny. The vast majority of laboratory animals are mice living in small cages that do not offer very much variety. Moreover, the experimental procedure often takes very little time compared to the time these animals have been bred to the desired age or are being held available for animal experimentation. However, for the assessment of animal welfare, the time spent waiting for an experiment or the time spent after finishing an experiment has also to be taken into acc

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19

Shchelkunov, S. N., A. A. Sergeev, S. N. Yakubitskyi, K. A. Titova, and S. A. Pyankov. "Assessing immunogenicity and protectiveness of the vaccinia virus LIVP-GFP in three laboratory animal models." Russian Journal of Infection and Immunity 11, no. 6 (October 7, 2021): 1167–72. http://dx.doi.org/10.15789/2220-7619-aia-1668.

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Smallpox eradication and lack of adequate animal model for smallpox infection underlies a necessity to assess immunogenic and protective properties of genetic engineering-created live attenuated smallpox vaccines in several animal models of orthopoxviral infections. Here we compared immunogenic and protective properties of the recombinant vaccinia virus (VACV) LIVP-GFP intradermally (i.d.) inoculated to mice, guinea pigs and rabbits. LIVP-GFP immunization in all animal species was applied at dose of 2 × 104 or 2 × 106 PFU. Control animals were injected with saline. Blood sampling was performed

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20

Neely, Caroline, Christina Lane, Julio Torres, and Jane Flinn. "The Effect of Gentle Handling on Depressive-Like Behavior in Adult Male Mice: Considerations for Human and Rodent Interactions in the Laboratory." Behavioural Neurology 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/2976014.

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Environmental factors play a significant role in well-being of laboratory animals. Regulations and guidelines recommend, if not require, that stressors such as bright lighting, smells, and noises are eliminated or reduced to maximize animal well-being. A factor that is often overlooked is handling and how researchers interact with their animals. Researchers, lab assistants, and husbandry staff in animal facilities may use inconsistent handling methods when interacting with rodents, but humans should be considered a part of the animal’s social environment. This study examined the effects of dif

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21

Viney, Mark. "The gut microbiota of wild rodents: Challenges and opportunities." Laboratory Animals 53, no. 3 (July 20, 2018): 252–58. http://dx.doi.org/10.1177/0023677218787538.

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The gut microbiota can have important, wide-ranging effects on its host. To date, laboratory animals, particularly mice, have been the major study system for microbiota research. It is now becoming increasingly clear that laboratory animals often poorly model aspects of the biology of wild animals, and this concern extends to the study of the gut microbiota. Here, the relatively few studies of the microbiota of wild rodents are reviewed, including a critical assessment of how the gut microbiota differs between laboratory and wild rodents. Finally, the many potential advantages and opportunitie

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22

Alkhashab, Firas M. B., Aseel Isam Jamal aldeen Alnuri, and Rana Suhail Abdallah Al_Juwari. "Detecting intestinal parasitic infections in laboratory mice." Journal of World's Poultry Research 10, no. 2 (June 25, 2020): 183–89. http://dx.doi.org/10.36380/scil.2020.wvj24.

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23

K., Sarab S., Rawaa G. T., Shahla A., Melad A. H., and Adel H. E. "The toxic effect of the malathion pesticide on laboratory animals." Journal of Biotechnology Research Center 8, no. 4 (December 1, 2014): 57–63. http://dx.doi.org/10.24126/jobrc.2014.8.4.385.

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The research aimed to illustrate enzyme level such as liver and immune enzymes to detect toxic effect of chemical agriculture pesticides as biological indictors to chemical pesticides contamination. 102 laboratory mice were used as a model 20-25gm weight. 30 mice were used to determine LD50 which was 30 mg/mouse. Mice were divided in to three groups according to LD50. After exposed to three different concentration by three ways (Interaperitoneal,Oraly,and Spray). Results showed significant increased in enzymes levels of (ALP), (GOT), (GPT), and (ADA) after 7 days of the three different exposur

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Vagaiskaya, A. S., A. S. Trunyakova, T. I. Kombarova, and S. V. Dentovskaya. "Simulation of Bubonic Plague in BSL-2 Laboratory." Problems of Particularly Dangerous Infections, no. 4 (January 25, 2022): 46–53. http://dx.doi.org/10.21055/0370-1069-2021-4-46-53.

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The causative agent of plague, Yersinia pestis, is classified as pathogenicity (hazard) group I agent, which means that the work with “wild type” strains should be carried out in BSL-3 facilities. Y. pestis EV NIIEG is a Δpgm strain, allowing experimental studies to be carried out in BSL-2 laboratories. However, the disease and its progression elicited by such strain do not entirely mirror the infection observed with fully virulent strains. Residual virulence of Y. pestis EV NIIEG strain for mice can be increased under in vivo iron supplementation. The aim of the study was to optimize methodol

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25

Schweinfurth, Nina, and Undine E. Lang. "Behavioral Testing of Mice Concerning Anxiety and Depression." Zeitschrift für Psychologie 223, no. 3 (July 2015): 151–56. http://dx.doi.org/10.1027/2151-2604/a000215.

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Abstract. In the development of new psychiatric drugs and the exploration of their efficacy, behavioral testing in mice has always shown to be an inevitable procedure. By studying the behavior of mice, diverse pathophysiological processes leading to depression, anxiety, and sickness behavior have been revealed. Moreover, laboratory research in animals increased at least the knowledge about the involvement of a multitude of genes in anxiety and depression. However, multiple new possibilities to study human behavior have been developed recently and improved and enable a direct acquisition of hum

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26

Ermakova, A. V., and A. G. Kudyasheva. "Variability of hematological parameters in different species of laboratory mice." Proceedings of the Komi Science Centre of the Ural Division of the Russian Academy of Sciences 5 (2021): 13–19. http://dx.doi.org/10.19110/1994-5655-2021-5-13-19.

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In scientific research, when conducting experiments, the so-called norms which are used to differentiate the state of health and pathology, are important. At the same time, the requirements for the quality of laboratory animals and their standardization as an object of research are increasing. These are mice of different species that are the main objects used in biomedical research in experiments when analyzing the age-related variability and toxicity of drugs of a chemical nature, modeling the effects of a physical nature, which allow us to obtain objective data. The study of hematological pa

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27

GOURTSAS (K.I. ΓΚΟΥΡΤΣΑΣ), K. I. "Common non infectious skin conditions of laboratory mice and rats." Journal of the Hellenic Veterinary Medical Society 50, no. 1 (January 31, 2018): 11. http://dx.doi.org/10.12681/jhvms.15693.

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Laboratory mice and rats are the most favourite animals of the researchers all over the world. Sometimes these rodents can show a number of non infectious conditions concerning their hair, skin or legs and tail. These can be alopecia, bite wounds or the shedding of their legs or tail. It is important that ordinarily there is not a pathological cause for these conditions. It is believed that the social behaviour and the enviromental conditions of the animals may play a role. Fortunately, these cases are easily encountered and so, healthy animals are ensured for every reliable research.

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Pivova, Elena Yurievna, Mikhail Evgenievich Vlasov, Timofey Aleksandrovich Sevskikh, Olga Sergeevna Povolyaeva, and Sergey Petrovich Zhivoderov. "A Study of the Susceptibility of Laboratory Animals to the Lumpy Skin Disease Virus." Life 13, no. 7 (June 30, 2023): 1489. http://dx.doi.org/10.3390/life13071489.

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This article presents the results of a study on the susceptibility of laboratory animals to the lumpy skin disease virus (LSDV). Mice weighing 15–20 g, hamsters weighing 40–60 g, guinea pigs weighing 600–1200 g, and rabbits weighing 2.5–3 kg were used in this study. Nodules were observed on the skin of rabbits and hamsters at the sites of inoculation. The virus was isolated from the affected skin areas in cell culture and examined using real-time PCR, indicating its tropism for animal skin. The production of anticapripoxvirus antibodies was detected using the neutralization reaction, starting

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29

FESTING, M. F. W., and G. L. WOLFF. "Re: Inbred Strains of Laboratory Animals: Superior to Outbred Mice?" JNCI Journal of the National Cancer Institute 87, no. 22 (November 15, 1995): 1715. http://dx.doi.org/10.1093/jnci/87.22.1715.

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ABRAMOVICI, A., and M. WOLMAN. "Re: Inbred Strains of Laboratory Animals: Superior to Outbred Mice?" JNCI Journal of the National Cancer Institute 87, no. 22 (November 15, 1995): 1715–16. http://dx.doi.org/10.1093/jnci/87.22.1715-a.

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31

Sherwin, CM, and IAS Olsson. "Housing conditions affect self-administration of anxiolytic by laboratory mice." Animal Welfare 13, no. 1 (February 2004): 33–38. http://dx.doi.org/10.1017/s0962728600026634.

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AbstractTests of emotionality conducted outside the home-cage show that rodents from standard laboratory housing are more anxious than animals from enriched housing; however, it is not known if this also indicates increased anxiety within the home-cage. We used a novel method, recording the self-administration of a psychoactive anxiolytic, to examine home-cage anxiety levels of laboratory mice (three per cage) in Standard (n = 10 cages), Unpredictable (n = 10 cages) and Enriched (n = 6 cages) housing. The mice were given a choice of drinking either non-drugged water or a solution of the benzod

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32

Fujiwara, Shigeyoshi, and Hiroyuki Nakamura. "Animal Models for Gammaherpesvirus Infections: Recent Development in the Analysis of Virus-Induced Pathogenesis." Pathogens 9, no. 2 (February 12, 2020): 116. http://dx.doi.org/10.3390/pathogens9020116.

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Epstein–Barr virus (EBV) is involved in the pathogenesis of various lymphomas and carcinomas, whereas Kaposi’s sarcoma-associated herpesvirus (KSHV) participates in the pathogenesis of endothelial sarcoma and lymphomas. EBV and KSHV are responsible for 120,000 and 44,000 annual new cases of cancer, respectively. Despite this clinical importance, no chemotherapies or vaccines have been developed for virus-specific treatment and prevention of these viruses. Humans are the only natural host for both EBV and KSHV, and only a limited species of laboratory animals are susceptible to their experiment

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Rix, Anne, Natascha Drude, Anna Mrugalla, Felix M. Mottaghy, René H. Tolba, and Fabian Kiessling. "Performance of severity parameters to detect chemotherapy-induced pain and distress in mice." Laboratory Animals 54, no. 5 (October 29, 2019): 452–60. http://dx.doi.org/10.1177/0023677219883327.

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According to European Union directive 2010/63/EU a severity classification of experimental procedures performed on laboratory animals is mandatory. This includes a prospective evaluation of all interventions performed within the experiment, as well as an assessment of the actual burden of each animal during the experiment. In this regard, the evaluation and scoring of defined criteria regarding the health state of animals could help to early identify deteriorations in animal health and facilitate the application of humane endpoints. This article discusses the applicability of an adapted score

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Hidayat, Rachmat, and Patricia Wulandari. "Handling of Common Laboratory Animals in Biomedical Study." Bioscientia Medicina : Journal of Biomedicine and Translational Research 5, no. 3 (March 8, 2021): 534–38. http://dx.doi.org/10.32539/bsm.v5i3.313.

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Mice are usually caught and lifted by the tail. The tail should be grasped abouttwo-thirds of the way down. With this simple method of holding, they may betransferred to another cage or a balance, identified or sexed; but such restraint isnot sufficient for treatment and close examination. For more effective control, themouse may be held by the tail and placed on a table or other surface, preferablyone that the mouse can grasp, and the loose skin over the neck and shouldersgrasped with thumb and fingers.

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Hidayat, Rachmat, and Patricia Wulandari. "Handling of Common Laboratory Animals in Biomedical Study." Bioscientia Medicina : Journal of Biomedicine and Translational Research 5, no. 9 (March 8, 2021): 851–55. http://dx.doi.org/10.32539/bsm.v5i9.313.

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Mice are usually caught and lifted by the tail. The tail should be grasped abouttwo-thirds of the way down. With this simple method of holding, they may betransferred to another cage or a balance, identified or sexed; but such restraint isnot sufficient for treatment and close examination. For more effective control, themouse may be held by the tail and placed on a table or other surface, preferablyone that the mouse can grasp, and the loose skin over the neck and shouldersgrasped with thumb and fingers.

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36

Rose, Margaret. "Welfare Phenotyping of Genetically-Modified Mice." Alternatives to Laboratory Animals 37, no. 2 (April 2009): 181–86. http://dx.doi.org/10.1177/026119290903700206.

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Technologies that enable the targeted manipulation of the genome have created new opportunities to study the role and interplay of specific genes in both the regulation and function of physiological and behavioural processes and in the development of pathological conditions. Despite the potential benefits, there are ethical issues in relation to the application of these technologies, some of which relate to the impact on the welfare of the animals involved. Matters of concern include the methods involved in the derivation and production of genetically-modified (GM) animals and resulting phenot

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Makowska, I. Joanna, Lori Vickers, Jane Mancell, and Daniel M. Weary. "Evaluating methods of gas euthanasia for laboratory mice." Applied Animal Behaviour Science 121, no. 3-4 (December 2009): 230–35. http://dx.doi.org/10.1016/j.applanim.2009.10.001.

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38

Freymann, Jennifer, Ping-Ping Tsai, Helge Stelzer, and Hansjoachim Hackbarth. "The impact of bedding volumes on laboratory mice." Applied Animal Behaviour Science 186 (January 2017): 72–79. http://dx.doi.org/10.1016/j.applanim.2016.11.004.

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39

Smith, William. "Responses of laboratory animals to some injectable anaesthetics." Laboratory Animals 27, no. 1 (January 1, 1993): 30–39. http://dx.doi.org/10.1258/002367793781082377.

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Xylazine, ketamine, methohexitone and alphadalone/alphaxalone, were administered intraperitoneally, intramuscularly or intravenously to mice, rats, guineapigs and rabbits. Times for disappearance and reappearance of reflexes were recorded, and duration of loss of reflex. Delivering a predetermined dose gave a varying individual response, ranging from inadequate anaesthesia to death. Using reflexes to assess depth of anaesthesia was of limited value. Reflex movements to noxious stimuli generally persisted even at dose rates that caused prolonged recovery times and death. Conversely, in rats the

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Kalueff, A. V., and P. Tuohimaa. "The role of hair in swimming of laboratory mice: implications for behavioural studies in animals with abnormal hair." Laboratory Animals 39, no. 4 (October 1, 2005): 370–76. http://dx.doi.org/10.1258/002367705774286376.

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Animal swimming tests, such as the forced swim test, are extensively used in biomedical research to study rodent behaviour. Hair and skin exposed to water may be an important factor affecting the performance in this test. Since various hair and skin abnormalities are not uncommon in genetically modified or drug-treated laboratory animals, this test may be inappropriate for these animals. Because on occasions it is necessary to screen their swimming behaviour, in the present study we aimed to assess the role of hair in swimming of laboratory rodents in the forced swim test, widely used in behav

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Catarinucci, Luca, Riccardo Colella, Luca Mainetti, Vincenzo Mighali, Luigi Patrono, Ilaria Sergi, and Luciano Tarricone. "Near Field UHF RFID Antenna System Enabling the Tracking of Small Laboratory Animals." International Journal of Antennas and Propagation 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/713943.

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Radio frequency identification (RFID) technology is more and more adopted in a wide range of applicative scenarios. In many cases, such as the tracking of small-size living animals for behaviour analysis purposes, the straightforward use of commercial solutions does not ensure adequate performance. Consequently, both RFID hardware and the control software should be tailored for the particular application. In this work, a novel RFID-based approach enabling an effective localization and tracking of small-sized laboratory animals is proposed. It is mainly based on a UHF Near Field RFID multianten

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Kubanov, A. A., A. E. Karamova, K. V. Rog, T. V. Abramova, V. A. Smolyannikova, A. N. Murashev, and D. A. Bondarenko. "Development of an experimental model of pemphigus vulgaris in laboratory animals." Vestnik dermatologii i venerologii 91, no. 4 (August 24, 2015): 76–82. http://dx.doi.org/10.25208/0042-4609-2015-91-4-76-82.

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Pemphigus vulgaris is a chronic autoimmune bullous disease characterized by the formation of blisters on the skin and/ or mucous tunics as a result of acantholysis. To search for new molecular and biological targets, study pathogenetic mechanisms of the disease development and develop new methods of treatment, it is urgent to create an experimental model of pemphigus in laboratory animals reproducing clinical, histological and immunological signs of pemphigus. Goal of the study. To develop an experimental model of pemphigus by injecting IgG produced from the blood serum taken from patients wit

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Fuller, Claire A. "Variable levels of immunity to experimental Eimetia arizonensis infections in natural, seminatural, and laboratory populations of deer mice (Peromyscus maniculatus)." Canadian Journal of Zoology 74, no. 4 (April 1, 1996): 750–57. http://dx.doi.org/10.1139/z96-085.

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Acquired immunity to parasites may affect both host and parasite population dynamics. Although immunity has been studied experimentally in laboratory-reared hosts, less attention has focused on free-living animals. I examined acquired immunity of free-living deer mice (Peromyscus maniculatus) to naturally occurring and experimental infections of Eimeria arizonensis (Protozoa: Coccidia). In a mark – recapture study, I found evidence of complete immunity to natural infections in only 1 of 3 years and evidence of partial immunity in all years. I subsequently examined partial immunity to experimen

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Field, K. J., and C. M. Lang. "Hazards of urethane (ethyl carbamate): a review of the literature." Laboratory Animals 22, no. 3 (July 1, 1988): 255–62. http://dx.doi.org/10.1258/002367788780746331.

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Urethane (ethyl carbamate) is used alone or in combination with other drugs to produce anaesthesia in laboratory animals. Although originally studied as a potential phytocide, urethane demonstrated antineoplastic properties when administered to rats with the Walker rat carcinoma 256. Subsequent trials in humans led to its use as a chemotherapeutic agent for various leukaemias. Mice develop pulmonary adenomas earlier in life and at a higher incidence following urethane administration. Urethane's carcinogenic influence is greater in neonatal mice; it also has a transplacental influence in mice.

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Namgyal, Dhondup, Kumari Chandan, Sher Ali, Ajaz Ahmad, Maha J. Hashim, and Maryam Sarwat. "Aberrant Lighting Causes Anxiety-like Behavior in Mice but Curcumin Ameliorates the Symptoms." Animals 11, no. 9 (September 3, 2021): 2590. http://dx.doi.org/10.3390/ani11092590.

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In the modern research field, laboratory animals are constantly kept under artificial lighting conditions. However, recent studies have shown the effect of artificial light on animal behavior and metabolism. In the present study on mice, following three weeks of housing in dim light at night (dLAN; 5lux) and complete darkness (DD; 0lux), we monitored the effect on body weight, daily food intake, anxiety-like behavior by employing the open field test, and expression of the period (PER1) gene. We also studied the effect of oral administration of different concentrations of curcumin (50, 100, and

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Van de Weerd, H. A., P. L. P. Van Loo, L. F. M. Van Zutphen, J. M. Koolhaas, and V. Baumans. "Preferences for nesting material as environmental enrichment for laboratory mice." Laboratory Animals 31, no. 2 (April 1, 1997): 133–43. http://dx.doi.org/10.1258/002367797780600152.

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Behavioural and psychological needs of laboratory animals generally cannot adequately be met in standard laboratory cages. Environmental enrichment, which provides a more structured environment can enhance the well-being of laboratory animals. They may perform more of their species-specific behaviour and may control their environment in a better way. An easily applicable form of enrichment for laboratory mice is nesting material. Six different types of nesting materials were evaluated in a preference test with male and female animals of two strains (C57BL/6J or BALB/c, n=48). No significant di

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Zibarev, Evgeny V., A. S. Afanasev, O. V. Slusareva, and I. D. Bulavina. "EXPLORATORY STUDIES OF THE INFLUENCE OF WIRELESS EQUIPMENT ON THE BODY OF LABORATORY ANIMALS." Hygiene and sanitation 96, no. 7 (March 27, 2019): 661–64. http://dx.doi.org/10.18821/0016-9900-2017-96-7-661-664.

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Тhe article presents results of exploratory research on the assessment of the impact of Wi-Fi equipment on the organism of laboratory animals. The study was executed in a specially equipped semi-anechoic chambers, to eliminate the influence of other sources, which can have a direct or indirect impact on animals. As a source of EMR there was used the router for wireless access to the Internet (brand: ZyXEL KeeneticExtra). Laboratory animals (20 white male mice), and control group (20 animals)were placed at a distance of 0.5 m and 1 m from the EMR source in a room without EMR source. Weekly ever

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Bondarchuk, A. O., A. P. Paliy, A. P. Palii, and A. P. Aksonov. "Determination of acute toxicity of the ‘Bondarmin’ disinfectant when administered intraperitoneally to laboratory animals." Journal for Veterinary Medicine, Biotechnology and Biosafety 6, no. 4 (December 1, 2020): 25–28. http://dx.doi.org/10.36016/jvmbbs-2020-6-4-5.

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The article presents the results of the study of the acute toxic effect of the innovative disinfectant ‘Bondarmin’ (active substance — potassium peroxomonosulfate) on laboratory animals (mice, rats) are presented. Many scientific works of scientists in recent years have been devoted to the study of the toxicity of various disinfectants both in our country and abroad. However, today there are many topical issues regarding the toxicity and safety of some antimicrobials. Our work aimed to study the toxic effect on the laboratory animals and to establish the acute toxicity (LD50) of the developed

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Varkholiak, I. S., and B. V. Gutyj. "Determination of acute toxicity of “Bendamin” drug in laboratory animals." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 20, no. 92 (December 10, 2018): 209–12. http://dx.doi.org/10.32718/nvlvet9243.

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The study of acute toxicity is a mandatory stage in the investigation of new drugs, which allows assessing the health of substances for health in the short-term and determining the class of toxicity and breadth of therapeutic action. Therefore, at the first stage of the study, the acute toxicity of Bendamin Cardiomatography was studied, in particular the determination of maximum tolerant, toxic and intermittent lethal doses for laboratory animals. The acute toxicity of Bendamin was determined in two stages: indicative and expanded experiments. In the indicative trial, the drug was administered

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Bicalho, K. A., F. T. M. Araújo, R. S. Rocha, and O. S. Carvalho. "Sanitary profile in mice and rat colonies in laboratory animal houses in Minas Gerais: I - Endo and ectoparasites." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 59, no. 6 (December 2007): 1478–84. http://dx.doi.org/10.1590/s0102-09352007000600020.

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The sanitary conditions of 13 animal houses in nine public institutions in Minas Gerais, and the presence of endo and ectoparasites of mice and rats colonies kept in these facilities were evaluated. Data about barriers to prevent the transmission of diseases and a program of sanitary monitoring were obtained through a questionnaire and local visit. Parasitological methods were performed for diagnosing mite, lice, helminthes, and protozoa parasites in 344 mice and 111 rats. Data have shown that the majority of the animal houses had neither proper physical environment nor protection barriers to

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