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Journal articles on the topic 'Mice Effect of temperature on'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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1

Fischer, Alexander W., Robert I. Csikasz, Gabriella von Essen, Barbara Cannon, and Jan Nedergaard. "No insulating effect of obesity." American Journal of Physiology-Endocrinology and Metabolism 311, no. 1 (July 1, 2016): E202—E213. http://dx.doi.org/10.1152/ajpendo.00093.2016.

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The development of obesity may be aggravated if obesity itself insulates against heat loss and thus diminishes the amount of food burnt for body temperature control. This would be particularly important under normal laboratory conditions where mice experience a chronic cold stress (at ≈20°C). We used Scholander plots (energy expenditure plotted against ambient temperature) to examine the insulation (thermal conductance) of mice, defined as the inverse of the slope of the Scholander curve at subthermoneutral temperatures. We verified the method by demonstrating that shaved mice possessed only h

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2

Kluger, M. J., C. A. Conn, B. Franklin, R. Freter, and G. D. Abrams. "Effect of gastrointestinal flora on body temperature of rats and mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 258, no. 2 (February 1, 1990): R552—R557. http://dx.doi.org/10.1152/ajpregu.1990.258.2.r552.

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The purpose of these experiments was to test the hypothesis that gut flora influences the body temperature of rodents. Rats and mice were implanted with biotelemetry transmitters that enabled us to record both abdominal temperature and activity for long periods of time. Rats given nonabsorbable antibiotics in their drinking water, which reduced their gut flora, had a marked decrease in both their daytime and nighttime temperatures. Similar results were found with germfree mice. The circadian rhythms in body temperature of germfree and conventionalized mice were not different. However, the body

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3

Miyazaki, S., F. Ishikawa, S. Matsuo, and K. Yamaguchi. "Effect of fluoroquinolones on body temperature of mice." Journal of Antimicrobial Chemotherapy 62, no. 6 (September 10, 2008): 1319–22. http://dx.doi.org/10.1093/jac/dkn418.

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4

Hishimura, Yutaka, and Kana Itoh. "Effect of social interaction on skin temperature in mice." Japanese journal of psychology 80, no. 2 (2009): 152–58. http://dx.doi.org/10.4992/jjpsy.80.152.

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5

Vargas, M. L., F. Tejada, A. Peñuela, R. Peñafiel, and A. Cremades. "Effect of potassium deficiency on body temperature in mice." Journal of Thermal Biology 25, no. 1-2 (February 2000): 125–29. http://dx.doi.org/10.1016/s0306-4565(99)00089-3.

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6

Izumizaki, Masahiko, Michiko Iwase, Hiroshi Kimura, Takayuki Kuriyama, and Ikuo Homma. "Central histamine contributed to temperature-induced polypnea in mice." Journal of Applied Physiology 89, no. 2 (August 1, 2000): 770–76. http://dx.doi.org/10.1152/jappl.2000.89.2.770.

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Breathing pattern is influenced by body temperature. However, the central mechanism for changing breathing patterns is unknown. Central histamine is involved in heat loss mechanisms in behavioral studies, but little is known about its effect on breathing patterns. We examined first the effect of body temperature on breathing patterns with increasing hypercapnia in conscious mice and then that of the depletion of central histamine by S(+)-α-fluoromethylhistidine hydrochloride (α-FMH) (100 mg/kg ip), a specific inhibitor of histidine decarboxylase, at normal and raised body temperatures. A raise

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Gatti, Silvia, Jennifer Beck, Giamila Fantuzzi, Tamas Bartfai, and Charles A. Dinarello. "Effect of interleukin-18 on mouse core body temperature." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 282, no. 3 (March 1, 2002): R702—R709. http://dx.doi.org/10.1152/ajpregu.00393.2001.

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We have studied, using a telemetry system, the pyrogenic properties of recombinant murine interleukin-18 (rmIL-18) injected into the peritoneum of C57BL/6 mice. The effect of IL-18 was compared with the febrile response induced by human IL-1β, lipopolysaccharide (LPS), and recombinant murine interferon-γ (rmIFN-γ). Both IL-1β and LPS induced a febrile response within the first hour after the intraperitoneal injection, whereas rmIL-18 (10–200 μg/kg) and rmIFN-γ (10–150 μg/kg) did not cause significant changes in the core body temperature of mice. Surprisingly, increasing doses of IL-18, injecte

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8

Hassan, Intisar A., Zachary Renfro, Harrison Blake, Satyajit Rath, and Jeannine M. Durdik. "Effect of temperature on functional activity of macrophages in three different species." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 149.17. http://dx.doi.org/10.4049/jimmunol.204.supp.149.17.

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Abstract Temperature affects body physiological functions, including immunity in ways that influence survival. This study investigated the effect of temperature on macrophage activation and metabolism across species. Macrophages were isolated from mice, chicken or rainbow trout primary tissue or from macrophage cell lines and were activated with lipopolysaccharide (LPS) or IFN-γ. For mice, both Raw264.7 and primary cells, nitric oxide (NO) production was similar at 35°C and 37°C but dropped dramatically at temperatures below 35°C. At fever temperature (39°C), NO release increased in response t

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9

Small, Lewin, Henry Gong, Christian Yassmin, Gregory J. Cooney, and Amanda E. Brandon. "Thermoneutral housing does not influence fat mass or glucose homeostasis in C57BL/6 mice." Journal of Endocrinology 239, no. 3 (December 2018): 313–24. http://dx.doi.org/10.1530/joe-18-0279.

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One major factor affecting physiology often overlooked when comparing data from animal models and humans is the effect of ambient temperature. The majority of rodent housing is maintained at ~22°C, the thermoneutral temperature for lightly clothed humans. However, mice have a much higher thermoneutral temperature of ~30°C, consequently data collected at 22°C in mice could be influenced by animals being exposed to a chronic cold stress. The aim of this study was to investigate the effect of housing temperature on glucose homeostasis and energy metabolism of mice fed normal chow or a high-fat, o

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10

Konecka, Anna Maria, Irmina Sroczynska, and Andrzej W. Lipkowski. "The effect of enkephalin dimers on body temperature in mice." Peptides 8, no. 3 (May 1987): 431–35. http://dx.doi.org/10.1016/0196-9781(87)90005-2.

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11

O'Connor, C. S., L. I. Crawshaw, A. Kosobud, R. C. Bedichek, and J. C. Crabbe. "The effect of ethanol on behavioral temperature regulation in mice." Pharmacology Biochemistry and Behavior 33, no. 2 (June 1989): 315–19. http://dx.doi.org/10.1016/0091-3057(89)90506-6.

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12

Catalina, Fernando, Leon Milewich, William Frawley, Vinay Kumar, and Michael Bennett. "Decrease of Core Body Temperature in Mice by Dehydroepiandrosterone." Experimental Biology and Medicine 227, no. 6 (June 2002): 382–88. http://dx.doi.org/10.1177/153537020222700603.

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Dietary dehydroepiandrosterone (DHEA) reduces food intake in mice, and this response is under genetic control. Moreover, both food restriction and DHEA can prevent or ameliorate certain diseases and mediate other biological effects. Mice fed DHEA (0.45% w/w of food) and mice pair-fed to these mice (food restricted) for 8 weeks were tested for changes in body temperature. DHEA was more efficient than food restriction alone in causing hypothermia. DHEA injected intraperitoneally also induced hypothermia that reached a nadir at 1 to 2 hr, and slowly recovered by 20 to 24 hr. This effect was dose

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13

Zhou, Wei, Ruxue Lei, Chuanyi Zuo, Yunqing Yue, Qin Luo, Chengshun Zhang, Peng Lv, Yong Tang, Haiyan Yin, and Shuguang Yu. "Analgesic Effect of Moxibustion with Different Temperature on Inflammatory and Neuropathic Pain Mice: A Comparative Study." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/4373182.

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The aim of this study was to determine whether variation of temperature during moxibustion would generate division of analgesic effect. The moxibustion with different temperatures (37°C, 42°C, 47°C, and 52°C) was applied to ST36 acupoint for 30 minutes in chronic inflammatory or neuropathic pain mice. The analgesic effect was evaluated by thermal hyperalgesia test in chronic inflammatory pain and by mechanical allodynia in neuropathic pain, respectively. The results indicated that interventions of moxibustion with different temperature caused different analgesic effect on either chronic inflam

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14

Lewis, G. B. H. "Effect of Altered Environmental Temperature on Established Infection." Anaesthesia and Intensive Care 16, no. 3 (August 1988): 338–41. http://dx.doi.org/10.1177/0310057x8801600316.

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An alteration of ten degrees Celsius in environmental temperature significantly alters the mortality from severe established Escherichia coli and Staphylococcus aureus infection in mice. Many patients with severe infection are nursed in wards without air conditioning. It is suggested that even modest levels of environmental stress may influence their recovery.

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15

Chen, Minhui, Guanxi Qiao, Bonnie L. Hylander, Hemn Mohammadpour, Anurag K. Singh, and Elizabeth A. Repasky. "Mandated Cool Housing Temperature and Adrenergic Stress reduce the efficacy of radiation and mask the “Abscopal Effect” in mouse models of cancer." Journal of Immunology 202, no. 1_Supplement (May 1, 2019): 136.27. http://dx.doi.org/10.4049/jimmunol.202.supp.136.27.

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Abstract Mice used for modeling cancer and anti-tumor immunity experience increased adrenergic stress due to IACUC-mandated cool housing temperatures. We wondered if this source of stress could be impacting the efficacy of ionizing radiation and the frequency of an “abscopal” effect (in which tumors outside the field of irradiation exhibit a response, an effect linked to enhanced systemic anti-tumor immunity). When mice bearing two separate CT26 tumors were housed at a thermoneutral temperature (TT; ~30°C) and 6 Gy of radiation was delivered to one tumor, control of both the irradiated and non

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16

Conn, C. A., B. Franklin, R. Freter, and M. J. Kluger. "Role of gram-negative and gram-positive gastrointestinal flora in temperature regulation of mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 261, no. 6 (December 1, 1991): R1358—R1363. http://dx.doi.org/10.1152/ajpregu.1991.261.6.r1358.

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An earlier study showed that the presence of gut flora elevates body temperature of mice and rats. In these experiments, we questioned whether the signal coming from the gut was endotoxin from gram-negative (Gm-) bacteria or some signal derived from gram-positive (Gm+) microorganisms. To test the idea that endotoxin is responsible for the effects of flora, we compared the temperature of the endotoxin-resistant mouse (C3H/HeJ) with that of endotoxin-sensitive strains of mice (C3H/SnJ and C3H/HeN). Temperature of C3H/HeJ was not different from that of C3H/SnJ or C3H/HeN during the light period b

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17

Swoap, Steven J., J. Michael Overton, and Graham Garber. "Effect of ambient temperature on cardiovascular parameters in rats and mice: a comparative approach." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 287, no. 2 (August 2004): R391—R396. http://dx.doi.org/10.1152/ajpregu.00731.2003.

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Ambient air temperatures (Ta) of <6°C or >29°C have been shown to induce large changes in arterial blood pressure and heart rate in homeotherms. The present study was designed to investigate whether small incremental changes in Ta, such as those found in typical laboratory settings, would have an impact on blood pressure and other cardiovascular parameters in mice and rats. We predicted that small decreases in Ta would impact the cardiovascular parameters of mice more than rats due to the increased thermogenic demands resulting from a greater surface area-to-volume ratio in mice relative

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18

Richard, D., A. Labrie, and S. Rivest. "Tissue specificity of SNS response to exercise in mice exposed to low temperatures." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 262, no. 5 (May 1, 1992): R921—R925. http://dx.doi.org/10.1152/ajpregu.1992.262.5.r921.

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The present study was carried out to investigate the tissue specificity of the sympathetic nervous system (SNS) response to acute exercise in adult mice exposed to four ambient temperatures. SNS activity estimates in heart, pancreas, and brown adipose tissue (BAT) were obtained from the measurement of the dopamine (DA) tissue contents 1 h after the inhibition of the DA-beta-hydroxylase with 1-cyclohexyl-2-mercaptoimidazole (CHMI). DA was measured by electrochemical detection after the separation of the monoamine using high-performance liquid chromatography. In both heart and pancreas, temperat

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19

Wernstedt, Ingrid, Amanda Edgley, Anna Berndtsson, Jenny Fäldt, Göran Bergström, Ville Wallenius, and John-Olov Jansson. "Reduced stress- and cold-induced increase in energy expenditure in interleukin-6-deficient mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 291, no. 3 (September 2006): R551—R557. http://dx.doi.org/10.1152/ajpregu.00514.2005.

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Interleukin-6 (IL-6) deficient (-/-) mice develop mature onset obesity. Pharmacological studies have shown that IL-6 has direct lipolytic effects and when administered centrally increases sympathetic outflow. However, the metabolic functions of endogenous IL-6 are not fully elucidated. We aimed to investigate the effect of IL-6 deficiency with respect to cold exposure and cage-switch stress, that is, situations that normally increase sympathetic outflow. Energy metabolism, core temperature, heart rate, and activity were investigated in young preobese IL-6−/− mice by indirect calorimetry togeth

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20

Kolbe, Thomas, Caroline Lassnig, Andrea Poelzl, Rupert Palme, Kerstin E. Auer, and Thomas Rülicke. "Effect of Different Ambient Temperatures on Reproductive Outcome and Stress Level of Lactating Females in Two Mouse Strains." Animals 12, no. 16 (August 20, 2022): 2141. http://dx.doi.org/10.3390/ani12162141.

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Ambient temperature is an important non-biotic environmental factor influencing immunological and oncological parameters in laboratory mice. It is under discussion which temperature is more appropriate and whether the commonly used room temperature in rodent facilities of about 21 °C represents a chronic cold stress or the 30 °C of the thermoneutral zone constitutes heat stress for the animals. In this study, we selected the physiological challenging period of lactation to investigate the influence of a cage temperature of 20 °C, 25 °C, and 30 °C, respectively, on reproductive performance and

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21

Serrat, Maria A., Rebecca M. Williams, and Cornelia E. Farnum. "Exercise mitigates the stunting effect of cold temperature on limb elongation in mice by increasing solute delivery to the growth plate." Journal of Applied Physiology 109, no. 6 (December 2010): 1869–79. http://dx.doi.org/10.1152/japplphysiol.01022.2010.

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Ambient temperature and physical activity modulate bone elongation in mammals, but mechanisms underlying this plasticity are a century-old enigma. Longitudinal bone growth occurs in cartilaginous plates, which receive nutritional support via delivery of solutes from the vasculature. We tested the hypothesis that chronic exercise and warm temperature promote bone lengthening by increasing solute delivery to the growth plate, measured in real time using in vivo multiphoton microscopy. We housed 68 weanling female mice at cold (16°C) or warm (25°C) temperatures and allowed some groups voluntary a

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Gordon, C. J., and L. Fogelson. "Comparative effects of hypoxia on behavioral thermoregulation in rats, hamsters, and mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 260, no. 1 (January 1, 1991): R120—R125. http://dx.doi.org/10.1152/ajpregu.1991.260.1.r120.

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Recent studies using reptiles and other ectothermic species have shown that hypoxia lowers the set point for the control of body temperature. This is characterized by a preference for cooler ambient (Ta) and deep body temperatures (Tb) when placed in a temperature gradient. To elucidate the presence of this effect in mammals, the selected Ta and Tb of three rodent species (mouse, hamster, and rat) were measured while subjected to graded hypoxia in a temperature gradient. Individual animals were placed in the gradient for 30 min. Oxygen content of air entering the gradient was then reduced to a

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23

Waage, A., and T. Espevik. "Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice." Journal of Experimental Medicine 167, no. 6 (June 1, 1988): 1987–92. http://dx.doi.org/10.1084/jem.167.6.1987.

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Human rIL-1 alpha and human rIL-1 beta were examined for their ability to potentiate the lethal and hypothermic effects of mouse rTNF-alpha in mice. The LD50 of rTNF-alpha was 1.5 micrograms/mouse, whereas the LD50 of rTNF-alpha was reduced to 0.4 micrograms/mouse and 0.5 micrograms/mouse when rTNF-alpha was administered in combination with a nonlethal dose of rIL-1 alpha or rIL-1 beta, respectively. A similar rTNF-alpha enhancing effect of the rIL-1 was observed on the temperature response. The results show that the rIL-1 markedly potentiate the effects of rTNF-alpha on lethality and temperat

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Sosin, Denis Vladimirovich, Andrey Viktorovich Yevseyev, Edgar Andreyevich Parfenov, Vitaliy Andreyevich Pravdivtsev, Marina Anatolyevna Yevseyeva та Petr Dmitriyevich Shabanov. "HYPOTHERMIC EFFECT OF ANTIHYPOXANTS πQ1983 AND πQ2170". Reviews on Clinical Pharmacology and Drug Therapy 10, № 4 (15 грудня 2012): 78–82. http://dx.doi.org/10.17816/rcf10478-82.

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In experiments on mice the influence of the new antihypoxants (selenium containing metal complex substances πQ1983, πQ2170) on rectal temperature level dynamic after parenteral and enteral introductions was studied. It is established that both substances perform clear dose-dependent hypothermic effect exceeding an action of the antihypoxant amthizole. Was supposed that substance πQ2170 has high acute toxicity affirmed by significant mice death-rate.

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Russell, Lauren N., William S. Hyatt, Brenda M. Gannon, Christy M. Simecka, Mildred M. Randolph, and William E. Fantegrossi. "Effects of Laboratory Housing Conditions on Core Temperature and Locomotor Activity in Mice." Journal of the American Association for Laboratory Animal Science 60, no. 3 (May 1, 2021): 272–80. http://dx.doi.org/10.30802/aalas-jaalas-20-000093.

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Drug developers worldwide assess compound safety and efficacy using measures that include mouse core temperature and locomotor activity. Subtle differences in animal housing conditions between institutions can alter these values, impacting scientific rigor and reproducibility. In these studies, adult male NIH Swiss mice were surgically implanted with radiotelemetry probes that simultaneously monitored core temperature and locomotor activity across various housing conditions. In the first study, ambient temperature was varied between 20 °C and 28°C in groups of singly housed mice. Additional st

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Endo, Toyoshi, and Tetsuro Kobayashi. "Thyroid-stimulating hormone receptor in brown adipose tissue is involved in the regulation of thermogenesis." American Journal of Physiology-Endocrinology and Metabolism 295, no. 2 (August 2008): E514—E518. http://dx.doi.org/10.1152/ajpendo.90433.2008.

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C.RF- Tshrhyt/hyt mice have a mutated thyroid-stimulating hormone receptor (TSHR), and, without thyroid hormone supplementation, these mice develop severe hypothyroidism. When hypothyroid Tshrhyt/hyt mice were exposed to cold (4°C), rectal temperature rapidly dropped to 23.9 ± 0.40°C at 90 min, whereas the wild-type mice temperatures were 37.0 ± 0.15°C. When we carried out functional rat TSHR gene transfer in the brown adipose tissues by plasmid injection combined with electroporation, there was no effect on the serum levels of thyroxine, although rectal temperature of the mice transfected wit

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Dobrea, George M., and Cecilie Goodrich. "Pirenperone effects on temperature preference and body temperature in maturing mice." Physiology & Behavior 39, no. 3 (January 1987): 327–31. http://dx.doi.org/10.1016/0031-9384(87)90230-7.

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Wang, Gui-Ying, Ling-Ling Wang, Bin Xu, Jian-Bin Zhang, and Jin-Feng Jiang. "Effects of Moxibustion Temperature on Blood Cholesterol Level in a Mice Model of Acute Hyperlipidemia: Role of TRPV1." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/871704.

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Objectives. To compare the effects of moxibustion at two different temperatures (38°C and 46°C) on the blood cholesterol level in a mice model of acute hyperlipidemia, to detect the different expression levels of transient receptor potential vanilloid subfamily 1 (TRPV1) in the dorsal root ganglions of the wild mice, and to explore the correlation between TRPV1 and moxibustion’s cholesterol-lowering effects.Method. Two different mice models were used: C57BL/6J wild type (WT) and TRPV1 gene knockout (TRPV1−/−). Each model was randomly divided into control group and model group with three subgro

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29

Bidon, J. C., O. Souilem, M. Gogny, M. Blin, A. Tuan Vu, and A. Jondet. "Effect of temperature reduction on the vas deferens hyperresponsiveness of sensitized mice." Journal of Autonomic Pharmacology 15, no. 4 (August 1995): 227–38. http://dx.doi.org/10.1111/j.1474-8673.1995.tb00307.x.

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Tenchov, Boris, Silviya Abarova, Rumiana Koynova, Lubomir Traikov, and Lyubka Tancheva. "Low-temperature exothermic transitions in brain proteome of mice, effect of scopolamine." Thermochimica Acta 650 (April 2017): 26–32. http://dx.doi.org/10.1016/j.tca.2017.01.012.

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Binda, Maria Mercedes, Carlos Roger Molinas, Paul Hansen, and Philippe Robert Koninckx. "Effect of desiccation and temperature during laparoscopy on adhesion formation in mice." Fertility and Sterility 86, no. 1 (July 2006): 166–75. http://dx.doi.org/10.1016/j.fertnstert.2005.11.079.

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Huebert, Terry, William S. Evans, and Marianne Hardy. "Hymenolepis diminuta: The effect of cold temperature exposure on infections in mice." Experimental Parasitology 70, no. 4 (May 1990): 398–403. http://dx.doi.org/10.1016/0014-4894(90)90123-t.

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Berezkin, M. V., V. F. Kudinova, A. N. Batygov, L. E. Ponomareva, and G. N. Zhukova. "Effect of lighting conditions on circadian rhythm of rectal temperature in mice." Bulletin of Experimental Biology and Medicine 106, no. 3 (September 1988): 1337–40. http://dx.doi.org/10.1007/bf00834513.

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Rabearivony, Anjara, Huan Li, Shiyao Zhang, Siyu Chen, Xiaofei An, and Chang Liu. "Housing temperature affects the circadian rhythm of hepatic metabolism and clock genes." Journal of Endocrinology 247, no. 2 (November 2020): 183–95. http://dx.doi.org/10.1530/joe-20-0100.

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Environmental temperature remarkably impacts on metabolic homeostasis, raising a serious concern about the optimum housing temperature for translational studies. Recent studies suggested that mice should be housed slightly below their thermoneutral temperature (26°C). On the other hand, the external temperature, also known as a zeitgeber, can reset the circadian rhythm. However, whether housing temperature affects the circadian oscillators of the liver remains unknown. Therefore, we have compared the effect of two housing temperatures, namely 21°C (conventional; TC) and 26°C (thermoneutral; TN

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Alexander, Matthew, Kathleen Kokolus, Amanda Costa, Eleanor Clancy-Thompson, Elizabeth Repasky, and David Mullins. "Chronic cold-stress suppresses chemokine production and CD8+ T cell infiltration in the tumor microenvironment (TUM7P.1024)." Journal of Immunology 194, no. 1_Supplement (May 1, 2015): 142.13. http://dx.doi.org/10.4049/jimmunol.194.supp.142.13.

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Abstract Recently it was reported that maintenance of mice at thermoneutral temperatures (TT, the temperature at which basal metabolism is sufficient to maintain body temperature, 30oC) enhanced antitumor immune responses and reduced tumor growth, relative to standard vivarium temperatures (ST, 22oC). We hypothesized that mice maintained at ST may have impaired production of T cell chemoattractant cytokines and subsequent T cell infiltration. In mice bearing breast tumors or solid or metastatic-like melanomas, intratumoral expression of CXCL9 and CXCL10 (CXCR3-cognate chemokines) was enhanced

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Li, Xunde, Edward R. Atwill, Lissa A. Dunbar, and Kenneth W. Tate. "Effect of Daily Temperature Fluctuation during the Cool Season on the Infectivity of Cryptosporidium parvum." Applied and Environmental Microbiology 76, no. 4 (December 18, 2009): 989–93. http://dx.doi.org/10.1128/aem.02103-09.

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ABSTRACT The present work calculated the rate of inactivation of Cryptosporidium parvum oocysts attributable to daily oscillations of low ambient temperatures. The relationship between air temperature and the internal temperature of bovine feces on commercial operations was measured, and three representative 24-h thermal regimens in the ∼15°C, ∼25°C, and ∼35°C ranges were chosen and emulated using a thermocycler. C. parvum oocysts suspended in deionized water were exposed to the temperature cycles, and their infectivity in mice was tested. Oral inoculation of 103 treated oocysts per neonatal B

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Korani, Mitra, Sara Nikoofal-Sahlabadi, Amin R. Nikpoor, Solmaz Ghaffari, Hossein Attar, Mohammad Mashreghi, and Mahmoud R. Jaafari. "The Effect of Phase Transition Temperature on Therapeutic Efficacy of Liposomal Bortezomib." Anti-Cancer Agents in Medicinal Chemistry 20, no. 6 (June 14, 2020): 700–708. http://dx.doi.org/10.2174/1871520620666200101150640.

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Aims: Here, three liposomal formulations of DPPC/DPPG/Chol/DSPE-mPEG2000 (F1), DPPC/DPPG/Chol (F2) and HSPC/DPPG/Chol/DSPE-mPEG2000 (F3) encapsulating BTZ were prepared and characterized in terms of their size, surface charge, drug loading, and release profile. Mannitol was used as a trapping agent to entrap the BTZ inside the liposomal core. The cytotoxicity and anti-tumor activity of formulations were investigated in vitro and in vivo in mice bearing tumor. Background: Bortezomib (BTZ) is an FDA approved proteasome inhibitor for the treatment of mantle cell lymphoma and multiple myeloma. The

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Park, Eun-Young, Mi-Hwi Kim, Eung-Hwi Kim, Eun-Kyu Lee, In-Sun Park, Duck-Choon Yang, and Hee-Sook Jun. "Efficacy Comparison of Korean Ginseng and American Ginseng on Body Temperature and Metabolic Parameters." American Journal of Chinese Medicine 42, no. 01 (January 2014): 173–87. http://dx.doi.org/10.1142/s0192415x14500128.

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Ginseng has beneficial effects in cancer, diabetes and aging. There are two main varieties of ginseng: Panax ginseng (Korean ginseng) and Panax quinquefolius (American ginseng). There are anecdotal reports that American ginseng helps reduce body temperature, whereas Korean ginseng improves blood circulation and increases body temperature; however, their respective effects on body temperature and metabolic parameters have not been studied. We investigated body temperature and metabolic parameters in mice using a metabolic cage. After administering ginseng extracts acutely (single dose of 1000 m

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Su, Yang-Shuai, Juan-Juan Xin, Zhao-Kun Yang, Wei He, Hong Shi, Xiao-Yu Wang, Ling Hu, Xiang-Hong Jing, and Bing Zhu. "Effects of Different Local Moxibustion-Like Stimuli at Zusanli (ST36) and Zhongwan (CV12) on Gastric Motility and Its Underlying Receptor Mechanism." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/486963.

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The aim of this study was to explore the “intensity-response” relationship in local moxibustion-like stimuli- (LMS-) modulated gastric motility and its underlying receptor mechanism. Based on the thermal pain threshold (43°C), 41°C, 43°C, and 45°C LMS were separately applied to ST36 or CV12 for 180 s among ASIC3 knockout (ASIC3−/−) mice, TRPV1 knockout (TRPV1−/−) mice, and their homologous wild-type C57BL/6 mice (n=8in each group). Gastric motility was continuously measured by an intrapyloric balloon, and the amplitude, integral, and frequency of gastric motility during LMS were compared with

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Chen, Hubert C., Zuleika Ladha, Steven J. Smith, and Robert V. Farese. "Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1." American Journal of Physiology-Endocrinology and Metabolism 284, no. 1 (January 1, 2003): E213—E218. http://dx.doi.org/10.1152/ajpendo.00248.2002.

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Mice lacking acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a key enzyme in triglyceride synthesis, have increased energy expenditure and therefore are resistant to obesity. Because ambient temperature can significantly affect energy expenditure in mice, we undertook these studies to determine the effects of different ambient temperatures on energy expenditure, food intake, and thermoregulation in DGAT1-deficient [ Dgat1(−/−)] mice. Dgat1(−/−) mice had increased energy expenditure irrespective of changes in the ambient temperature. Although core temperature was normal, surface temperature

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Muzzi, Mirko, Francesco Blasi, Alessio Masi, Elisabetta Coppi, Chiara Traini, Roberta Felici, Maria Pittelli, et al. "Neurological Basis of AMP-Dependent Thermoregulation and its Relevance to Central and Peripheral Hyperthermia." Journal of Cerebral Blood Flow & Metabolism 33, no. 2 (October 24, 2012): 183–90. http://dx.doi.org/10.1038/jcbfm.2012.157.

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Therapeutic hypothermia is of relevance to treatment of increased body temperature and brain injury, but drugs inducing selective, rapid, and safe cooling in humans are not available. Here, we show that injections of adenosine 5′-monophosphate (AMP), an endogenous nucleotide, promptly triggers hypothermia in mice by directly activating adenosine A1 receptors (A1R) within the preoptic area (POA) of the hypothalamus. Inhibition of constitutive degradation of brain extracellular AMP by targeting ecto 5′-nucleotidase, also suffices to prompt hypothermia in rodents. Accordingly, sensitivity of mice

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Yang, Jiang-Ning, Jiang-Fan Chen, and Bertil B. Fredholm. "Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine." American Journal of Physiology-Heart and Circulatory Physiology 296, no. 4 (April 2009): H1141—H1149. http://dx.doi.org/10.1152/ajpheart.00754.2008.

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Heart rate (HR), body temperature (Temp), locomotor activity (LA), and oxygen consumption (O2C) were studied in awake mice lacking one or both of the adenosine A1 or A2A receptors (A1R or A2AR, respectively) using telemetry and respirometry, before and after caffeine administration. All parameters were lower during day than night and higher in females than males. When compared with wild-type (WT) littermates, HR was higher in male A1R knockout (A1RKO) mice but lower in A2ARKO mice and intermediate in A1-A2AR double KO mice. A single dose of an unselective β-blocker (timolol; 1 mg/kg) abolished

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Jun, Jonathan C., Mi-Kyung Shin, Qiaoling Yao, Ronald Devera, Shannon Fonti-Bevans, and Vsevolod Y. Polotsky. "Thermoneutrality modifies the impact of hypoxia on lipid metabolism." American Journal of Physiology-Endocrinology and Metabolism 304, no. 4 (February 15, 2013): E424—E435. http://dx.doi.org/10.1152/ajpendo.00515.2012.

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Hypoxia has been shown to rapidly increase triglycerides in mice by decreasing plasma lipoprotein clearance. However, the usual temperature of hypoxic exposure is below thermoneutrality for mice, which may increase thermogenesis and energy requirements, resulting in higher tissue lipid uptake. We hypothesize that decreased lipid clearance and ensuing hyperlipidemia are caused by hypoxic suppression of metabolism at cold temperatures and, therefore, would not occur at thermoneutrality. Twelve-week-old, male C57BL6/J mice were exposed to 6 h of 10% O2 at the usual temperature (22°C) or thermoneu

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Jennings, G., and M. Elia. "Effect of E. coli endotoxin on temperature, oxygen consumption and brown adipose tissue thermogenesis in rats and mice." Bioscience Reports 7, no. 6 (June 1, 1987): 517–23. http://dx.doi.org/10.1007/bf01116509.

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The effects of E. coli endotoxin 0127 B8 on oxygen consumption, temperature, and on the activity of the proton conductance pathway in brown adipose tissue (BAT) were investigated in rats and mice. In rats an increase was observed in rectal and skin temperature, whole body oxygen consumption and GDP binding in BAT. In mice only the rise in rectal and skin temperature were significantly changed by endotoxin administration. These findings suggest that in some species BAT is involved in the production of endotoxin induced fever and increased energy expenditure.

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Li Gao, Yinghu Zhao, and Zhaoliang Liu. "Immune Function Effect Analysis with Aspirin Based on Temperature Model Experiment of Mice." Journal of Convergence Information Technology 7, no. 16 (September 30, 2012): 11–18. http://dx.doi.org/10.4156/jcit.vol7.issue16.2.

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Cambridge, Naomi, and Emma S. J. Robinson. "Effect of BU98008, an imidazoline1-binding site ligand, on body temperature in mice." European Journal of Pharmacology 519, no. 1-2 (September 2005): 86–90. http://dx.doi.org/10.1016/j.ejphar.2005.07.010.

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Jensen, Birgitte, Jay F. Storz, and Angela Fago. "Bohr effect and temperature sensitivity of hemoglobins from highland and lowland deer mice." Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 195 (May 2016): 10–14. http://dx.doi.org/10.1016/j.cbpa.2016.01.018.

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Jackson, Helen C., Emma Ramsay, and D. J. Nutt. "Effect of the cyclopyrrolones suriclone and RP 59037 on body temperature in mice." European Journal of Pharmacology 216, no. 1 (May 1992): 23–27. http://dx.doi.org/10.1016/0014-2999(92)90204-h.

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Wilkinson, D. A., D. R. Burholt, and P. N. Shrivastava. "Hypothermia following whole-body heating of mice: Effect of heating time and temperature." International Journal of Hyperthermia 4, no. 2 (January 1988): 171–82. http://dx.doi.org/10.3109/02656738809029307.

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Tove, Samuel B., Rebecca Gooding, and Martin Nyajom. "Effect of Ambient Temperature on the Toxicity of Palmitoyl Glycerol in Weanling Mice." Journal of Nutrition 115, no. 11 (November 1, 1985): 1477–80. http://dx.doi.org/10.1093/jn/115.11.1477.

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