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1
Holder, Ridley B. "Selecting for lean gain efficiency in mice using different seletion criteria /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9737854.
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Byers, Shannon L. "Use of Inbred Strains of Mice to Study the Genetics and Biology of Sperm Function." Fogler Library, University of Maine, 2006. http://www.library.umaine.edu/theses/pdf/ByersSL2006.pdf.
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Bosk, Abigail. "Mating induced fos in forebrain neurons of female mice /." Norton, MA : Wheaton College, 2008. http://hdl.handle.net/10090/6013.
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Paterson, Andrew William James. "Mitochondrial abnormalities in PrP-null mice and Mecp2-null mice." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/29313.
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Evidence of a mitochondrial abnormality in PrP-null mice was sought by extensive assessment of the morphological and functional characteristics of isolated brain mitochondria. Study of isolated mitochondrial suspensions by electron microscopy revealed that PrP-null mitochondria were larger and, when cristae density was quantitatively measured using a novel technique, to have a reduced cristae density when compared to controls. A significant increase in respiratory capacity was detected in PrP-null mitochondria when metabolising Complex I substrates, but not when electrons entered downstream of complex 1. This implicates Complex 1 as a site for pathological change. As recent studies of the Mecp2-null mouse model of Rett syndrome detected increased transcription of Uqcrc1 (a core subunit of Complex III), mitochondrial morphology and respiration were studied in Mecp2-null mice. Whilst electron microscopy did not reveal any gross alterations in mitochondrial size or cristae density, respiration measurements revealed a severe phenotype in symptomatic, but not presymptomatic, Mecp2-null mice. Mitochondrial coupling was considerably reduced in isolated brain mitochondria from Mecp2-null mice indicating reduced mitochondrial efficiency. This effect was accompanied by an increase in respiratory capacity through Complex III. In order to determine if the overexpression of Uqcrc1 was causative in the production of the observed increase in respiratory capacity, the respiration rates of N2A cells overexpressing Uqcrc1 were measured. As transfected N2A cells showed significantly increased respiration rates through Complex III, the up-regulation of Uqcrc1 may be causative in producing the respiratory capacity increase observed in the animal model. These results enhance the evidence for dysfunctional mitochondria in both PrP-null and Mecp2-null mouse models and are discussed in relation to other investigations of prion disease, Rett syndrome and other models of neurodegenerative disease.
5
Braun, Stav. "Tracking multiple mice." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/77001.
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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 59-62).<br>Monitoring mouse social behaviors over long periods of time is essential for neurobehavioral analysis of social mouse phenotypes. Currently, the primary method of social behavioral plienotyping utilizes human labelers, which is slow and costly. In order to achieve the high throughput desired for scientific studies, social behavioral phenotyping must be automated. The problem of automation can be divided into two tasks; tracking and phenotyping. First, individual body parts of mice must be accurately tracked. This is achieved using shape context descriptors to obtain precise point to point correspondences between templates and mice in any frame of a video. This method provides for greater precision and accuracy than current state of the art techniques. We propose a means by which this tracking information can be used to classify social behaviors between mice.<br>by Stav Braun.<br>M.Eng.
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Chen, Xiaodi. "Identification, expression and characterization of Murine pepsinogen F /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9998474.
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Tsao, Jack W. "Wallerian degeneration in normal mice and in mutant C57BL/Wld mice." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260174.
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Verma, Sujeet. "Live plant and artificial plant settings are able to alleviate anxiety levels in mice an elevated plus-maze study /." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Thesis/Spring2009/S_Verma_042409.pdf.
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Thesis (M.S. in horticulture)--Washington State University, May 2009.<br>Title from PDF title page (viewed on July 28, 2009). "Department of Horticulture and Landscape Architecture." Includes bibliographical references (p. 51-58).
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Rambau, Ramugondo Victor. "Molecular genetics of Rhabdomys subspecies boundaries : phylogeography of mitochondrial lineages and chromosomal fluorescence in situ hybridization." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53504.
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Thesis (PhD)--University of Stellenbosch, 2003.<br>ENGLISH ABSTRACT: The geographic genetic population structure and evolutionary history of the African
four-striped mouse, Rhabdomys pumilio, was investigated using mitochondrial
(mtDNA) cytochrome b gene (1140 bp) and control region (994 bp) sequences and a
combination of cytogenetic banding techniques (G- and C-banding), and
fluorescence in situ hybridization. Two cytotypes (2n = 46 and 2n = 48) were
identified by cytogenetic analysis. No evidence of diploid number variation within
populations was found nor were there differences in gross chromosome morphology,
or subtle interchromosomal rearrangements at levels detected by ZOO-FISH. The
comparative painting data (using the complete suite, N = 20, of Mus musculus
chromosome specific painting probes) show that 10 mouse chromosomes have been
retained as chromosomal arms, or intact chromosome blocks within the R. pumilio
genome, six produced double signals, while the remaining four hybridized to three or
more R. pumilio chromosomes. In total, the 20 mouse chromosome paints detected
40 segments of conserved synteny. Their analysis revealed eight R. pumilio specific
contiguous segment associations, a further two that were shared by R. pumilio and
other rodents for which comparable data are available, the Black (Rattus rattus) and
Norwegian (Rattus nONegicus) rats, but not by the Chinese hamster, Cricetulus
grise us. The results suggest that mouse chromosomes 1, 10, and 17 have
undergone extensive rearrangements during genome evolution in the murids and
may be useful markers for enhancing our understanding of the mode and tempo of
chromosome evolution in rodents. Following initial studies using control region
sequences, the phylogeographic appraisal of R. pumilio was done using cytochrome
b gene sequences. Analyses based on a variety of analytical procedures resulted in
the detection of two major mtDNA lineages that correspond roughly to the xeric and
mesic biotic zones of southern Africa. One clade comprises specimens with 2n = 48,
and the other representatives of two cytotypes (2n = 48 and 2n = 46). The mean
sequence divergence (12.0%, range 8.3% -15.6%) separating the two mtDNA clades
is comparable to among-species variation within murid genera suggesting their
recognition as distinct species, the prior names for which would be R. dilecfus and R.
pumilio. Low sequence divergences and the diploid number dichotomy within the
mesic lineage support the recognition of two subspecies corresponding to R. d.
dilecfus (2n = 46) and R. d. chakae (2n = 48). The data do not support subspecific
division within the nominate, R. pumilio. Molecular dating places cladogenesis of the
two putative species at less than 5 million years, a period characterised by extensive
climatic oscillations which are thought to have resulted in habitat fragmentation
throughout much of the species' range.<br>AFRIKAANSE OPSOMMING: Die geografiesebevolkingsstruktuur en evolusionêre verwantskappe binne die Afrika
streepmuis, Rhabdoys pumilio, is ondersoek deur middel van mitochondriale ONS
volgordebepaling van die geenfragment sitochroom b (1140 basispare) en die
reguleerstreek (994 bp) in kombinasie met sitogenetiese tegnieke (G- en Cbandkleuring
en f1uoreseerende in situ hibridisasie). Twee sitotipes (2n = 46 en 2n =
48) is geidentifiseer deur sitogenetiese analasie. Geen bewys van variasie in die 2n
chromosoomgetal binne bevolkings is gevind nie. Verder is daar ook geen verskil in
die morfologies struktuur van chromosome aanwesig binne bevolkings nie.
Vergelykende data (verkry met behulp van die N = 20 Mus musculus
chromosoomspesifiekepeilers) dui daarop dat 10 muis chromosome behoud gebly
het as chromosoomarms of chromosoomblokke binne die R. pumilio genoom. Ses
peilers het dubbel seine gelewer terwyl die oorblywende vier peilers gehibridiseer het
aan drie of meer R. pumilio chromosome. In totaal het die 20
muischromosoomverwe 40 konserwatiewe segmente geidentifiseer. Die analise dui
agt R. pumilio spesifieke aaneenlopende segmentassosiasies aan, met 'n
addisionele twee wat deur R. pumilio en ander muisagtiges vir wie vergelykende data
beskikbaar is, byvoorbeeld die swart (Rattus rattus) en Noorweegse (R. norvegicus)
rot maar nie die Chinese hamster, Cricetulus grise us, gedeel word. Die resultate stel
voor dat muischromosoom 1, 10 en 17 ekstensiewe herrangskikkings ondergaan het
gedurende die genoom evolusie binne die Muridae en dat hulle waarskynlik
waardevolle merkers kan wees om beide die patroon en tempo van chromosome
evolusie in muisagtiges verder te kan verstaan. Die filogeografiese verwantskappe
binne R. pumilio is ondersoek deur middel van ONS volgordebepalings van die
reguleerstreek asook sitochroom b. Die resultate van hierdie studie het twee
divergente mitochondriale ONS eenhede ontdek wat gekorreleer kan word met
xeriese en mesiese klimaatsones binne suidelike Afrika. Een groep bestaan uit diere
met 2n = 48, terwyl die ander genetiese groep twee sitotipes (2n = 46 en 2n= 48)
insluit. 'n Gemiddelde genetiese divergensie van 12.0% (varieer tussen 8.3% -
15.5%) verdeel die twee mtDNS-groepe en is vergelykbaar met tussenspesievariasie
binne ander muisagtige genera, wat moontlik daarop dui dat twee verskillende
spesies teenwoordig is; die voorgestelde name is R. di/ectus en R. pumilio. Lae
genetiese divergensie binne die mesiese groep versterk die moontlike
teenwoordigheid van twee subspesies, R. d. di/ectus (2n = 46) en R. d. chakae (2n =
48). Die data verleen egter nie steun aan die divisie binne R. pumilio nie.
Molekulêre datering van die twee spesies dui daarop dat die divergensie ten minste 5
miljoen jaar gelede plaasgevind het. Die periode was gekarakteriseer deur ekstensiewe klimaatsossilasies, wat gely het tot habitat fragmentasie in die spesie se
verspreidingsgebied.
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Thayer, Kristina A. "Prenatal exposure to low doses of estrogen : reproductive effects in male and female mice and implications for regulation of endocrine disrupting environmental chemicals /." free to MU campus, to others for purchase, 1999. http://wwwlib.umi.com/cr/mo/fullcit?p9951127.
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Oghumu, Steve Onyeka. "Generation and Characterization of CXCR3 Bicistronic Reporter Mice and CXCR3 Transgenic Mice." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1274927351.
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Chandrasekar-Rao, Anjali. "Distribution and ecology of Hong Kong small mammals, with special reference to seasonality." Thesis, Hong Kong : University of Hong Kong, 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17311950.
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Plendl, Wolfgang. "Extinction learning in mice." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-121216.
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Ellmauthaler, Andreas, and Eric Wernsperger. "Biometric Identification of Mice." Thesis, Halmstad University, School of Information Science, Computer and Electrical Engineering (IDE), 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-1135.
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<p>The identification of laboratory mice has been an important issue in pharmaceutical applications ever since tests have been performed on animals. As biometric identification has become an increasingly important issue over the past decade, attempts are underway to replace traditional identification methods, which are mostly invasive and limited in code space. This thesis discusses a project that aims at identifying mice by biometrically examining the blood vessel patterns in their ears.</p><p>In the proposed algorithm, firstly, the blood vessel structure within the obtained images got enhanced before segmenting the image in blood vessel and non-blood vessel portions. In the next step a sufficient amount of unique feature points got extracted from the segmented image. The obtained feature points were afterwards used for the actual identification procedure.</p><p>Out of 20 mice, 18 could be identified successfully using the proposed algorithm.</p>
15
Davies, S. "Oocyte maturation in mice." Thesis, University of Essex, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377928.
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Slamova, I. "Modelling amyloidosis in mice." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1534595/.
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Amyloidosis is a group of disorders in which specific soluble proteins convert into insoluble extracellular fibrillar deposits. Certain mutations in amyloid prone proteins result in aggressive forms of the disease. β2-microglobulin (β2m), a cell surface protein and transthyretin (TTR), a normal plasma protein, are inherently amyloidogenic. In patients undergoing long-term dialysis, ineffective clearance of β2m from the plasma results in sustained increase of its concentration and its deposition as amyloid. Wild type TTR is the amyloid precursor in senile systemic amyloidosis, a cause of heart failure in the elderly, and various different mutations in the human TTR gene cause the autosomal dominant conditions familial amyloid polyneuropathy and familial amyloid cardiomyopathy. The D76N β2m variant causes highly penetrant hereditary systemic amyloidosis. Similarly, the S52P TTR variant also causes aggressive amyloidosis which is characterised by prominent cardiac ATTR deposits. Animal models for Aβ2m amyloidosis and ATTR amyloidosis have long been sought to enable a better understanding of disease mechanisms and for validation of diagnostic methods and treatments, but previous attempts to model these diseases in vivo have met with limited or no success. The aims of this project were to generate mouse models of: (1) Aβ2m amyloidosis and (2) cardiac ATTR amyloidosis by transgenic expression of these highly amyloidogenic variants. In the work presented here, hβ2mD76N transgenic mice and hTTRS52P transgenic mice were generated. Despite expressing high plasma concentrations of the amyloidogenic proteins, the mice did not spontaneously develop amyloidosis. After priming amyloid deposition with pre formed amyloid fibrils, the hβ2mD76N transgenic mice failed to develop amyloid deposits. It is notable that most of the β2m circulates bound in a complex, potentially limiting the availability of free β2m monomers for conversion into fibrils. In the hTTRS52P transgenic mice, priming of amyloid deposition with amyloid fibrils led to consistent and reproducible development of cardiac ATTR amyloidosis.
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McCormick, Kevin R. "IMMUNOMODULATORS IN SENESCENT MICE." VCU Scholars Compass, 1989. http://scholarscompass.vcu.edu/etd/5083.
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The suppression of the immune response in senescent animals, including humans, is not complete and may be ameliorated by specific interventions. Previous studies have suggested that the replacement of thymus factors lost with age may rejuvenate senescent immune function. Similarly, exogenous growth hormone has been reported to improve senescent immune function in certain mammals. Other studies with the immunomodulator PSK claim to restore tumor-induced immunosuppression even in aged mice. This project investigated the abilities of thymus supernatant, ovine growth hormone, and PSK to rejuvenate different
parameters of the senescent immune response.
In the first series of experiments, erythroid depleted bone marrow cells from 3 month and 24 month old CBA (Thy 1.2) mice were given to irradiated ARR (Thy1.1) mice and allowed
to repopulate for 30 days. Flow cytometry analysis using x mAb Thy 1.1 and Thy 1.2 revealed that the old bone marrow was deficient in its ability to repopulate the thymus. Subsequent experiments revealed that treatment of the old bone marrow with thymus supernatant, made from neonatal thymus cultures, could restore the thymus repopulating ability of these cells.
The second part of this project investigated the reported ability of growth hormone to rejuvenate the age-involuted thymus and senescent immune response. Limited success was achieved using subcutaneous timed-release pellets containing ovine growth hormone. Twenty-four month old mice treated in this manner for 8 weeks demonstrated larger thymuses with nearly normal thymus morphology, i.e. distinct cortical and medullary regions. Various assays of cellular immune function exhibited no improvement.
PSK injections every other day injections of 18 month old mice, for one month, resulted in an increase in splenic mass when compared to saline treated age—matched controls. There was no improvement in the thymus morphology or in the cellular immune function of the treated animals.
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Wang, Chunfang. "Cellular senescence in mice." Thesis, University of Newcastle upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485568.
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Bell, Cindy Lea. "Transport studies in primary cultures of mouse renal epithelial cells." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75363.
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The Hyp (hypophosphatemic) mouse, a murine homologue of X-linked hypophosphatemia (XLH) in man, is a Mendelian disorder of phosphate (Pi) homeostasis. The mutant genotype is characterized by abnormal Pi transport at the brush border membrane (BBM) of the proximal tubule and a defect in renal metabolism of vitamin D$ sb3$. The exact nature of these defects has not been elucidated.<br>In order to determine if the defect is intrinsic to the renal cell or dependent upon an extrinsic humoral factor, I established primary cultures of renal epithelial cells from normal and Hyp mouse kidney. The cultures demonstrated several differentiated properties of epithelial cells of the renal proximal tubule, the site of the Pi transport defect in the Hyp mouse.<br>Primary cultures initiated from Hyp mice had decreased Pi transport (expressed as an uptake ratio, Pi/$ alpha$-MG), and increased production of 24,25 dihydroxyvitamin D$ sb3$. These results provide evidence for the intrinsic nature of the primary defect in the Hyp mouse.<br>This appears to be the first time that expression of a mutant transport gene has been demonstrated in cultured renal cells.
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Bishop, Katherine Mary. "A threshold model for development of the corpus callosum in normal and acallosal mice." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq22952.pdf.
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Johnson, Joshua Edward Newland M. Christopher. "The opportunity for alternative reinforcement shortens bout length in BALB/c C57BL/6 mice." Auburn, Ala, 2008. http://repo.lib.auburn.edu/EtdRoot/2008/SUMMER/Psychology/Thesis/Johnson_Joshua_56.pdf.
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Lanoue, Alain Carleton University Dissertation Biology. "Use of corridors and scale of movement in farmland by peromyscus leucopus." Ottawa, 1988.
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Jackson, Claire. "Aspects of reproduction in the four-striped field mouse, Rhabdomys pumilio." Thesis, Rhodes University, 2000. http://hdl.handle.net/10962/d1005319.
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Rhabdomys pumilio, in the Eastern Cape of South Africa, does not use short day length as an inhibitory cue for reproductive activity, and, despite previous records indicating that these mice are strictly seasonal in their reproduction, litters have been found during the winters of some years,both in the Eastern Cape and in the Western Cape. This led me to believe that the reproductive activity of Rhabdomys pumilio is more opportunistic and that the cue or cues used to control reproduction are less predictable and, or more variable than the photoperiod cue used by many seasonally reproducing rodents. Two experiments were conducted, investigating the influence of low ambient temperature (15⁰C)and reduced food availability on the reproductive activity of both male and female four striped field mice. Mice were maintained in one of four conditions (food restricted at 15⁰C, food restricted at 26⁰C, ad lib. food at 15⁰C, and ad lib. food at 26⁰C) for 4 (males) and 8 weeks (females)(photoperiod 12L:12D, humidity 40%). Results indicated that the males reduced their reproductive activity slightly when exposed to either low temperature or low food availability and that maximum inhibition of reproduction occurred when mice were exposed to both low temperature and low food availability. However, female reproductive activity was inhibited when exposed to low food availability, irrespective of the temperature. Both sexes of mice showed varying abilities to resist fat loss and, in the males, the size of the fat store had a significant effect on reproduction. This varying ability to resist fat loss could be related to levels of activity and in the females (where activity was quantified), high activity scores were significantly associated with reproductive inhibition. These results support the hypothesis that reproduction in Rhabdomys pumilio is opportunistic and controlled by the availability of energy. I propose that the females will be more sensitive to reproductive inhibition due to their far greater post-fertilization responsibilities, where the reproductive activity of the females is rapidly inhibited by a reduction in food availability, while the males are less readily inhibited by low food availability or low temperature, unless the change in the controlling factors is severe enough, or prolonged, at which stage their reproductive activity will cease. The significance of opportunistic reproduction in the seasonal but unpredictable climate of the study area is discussed.
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Devine, Jill Christine. "POPULATION GENETICS OF GOLDEN MICE (OCHROTOMYS NUTTALLI) AND WHITE-FOOTED MICE (PEROMYSCUS LEUCOPUS)." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/theses/943.
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Golden mice (Ochrotomys nuttalli) are generally an elusive and rare species throughout their geographic range in the southeastern United States. They are considered to be habitat specialists that prefer dense understory consisting of shrubs and vines. Golden mice are less vagile, and likely disperse shorter distances than other sympatric species such as the white-footed mouse (Peromyscus leucopus). Conversely, white-footed mice are considered habitat generalists that inhabit a variety of habitat types, are more vagile, and disperse farther than golden mice. Because of this it is likely that golden mice have a lower genetic diversity and are more genetically subdivided than white-footed mice. In southern Illinois, golden mice are on the periphery of their range, which is one of the reasons they are on the state-threatened list in Illinois. It has been hypothesized that populations on the periphery of a species range will have more population structure and lower genetic diversity than populations in the core of the range. Tissue samples for golden mice and white-footed mice were collected from 24 sites throughout southern Illinois and 24 sites throughout the golden mouse core range. I analyzed 13 and 10 microsatellite markers as well as 594 and 624 base pairs of the mitochondrial control region for golden mice and white-footed mice, respectively, to characterize and compare the genetic diversity and population structure of both species. Overall haplotype diversity (0.76) and nucleotide diversity (0.20%) was lower in golden mice compared to white footed mice (0.99 and 1.97%). Results of an AMOVA using the mitochondrial control region revealed more subdivision among the 3 populations of golden mice (Φst = 0.099, P < 0.001) than among the 3 populations of white-footed mice (Φst = 0.058, P < 0.001). Microsatellite loci showed a similar trend with overall FST values of 0.027 (P < 0.001) for golden mice and 0.004 (P = 0.137) for white-footed mice. I intended to compare golden mouse individuals from southern Illinois and the core of the range, but too few individuals were collected from the core. More samples need to be collected throughout the core of the range to better understand the population genetics of golden mice in the core of the range compared to the periphery.
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Gobbett, Troy A. "Characterization of phosphofructokinase-M gene expression in preimplantation mouse embryos through the use of competitive reverse transcription-polymerase chain reaction." Virtual Press, 1999. http://liblink.bsu.edu/uhtbin/catkey/1133725.
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The preimplantation mouse embryo undergoes many metabolic changes as development proceeds. One major change is the switch from a pyruvate based metabolism, to a glucose based metabolism. The phosphofructokinase enzyme is the regulatory enzyme of glycolysis and is thought to be a major contributor in controlling the block to glycolysis in early preimplantation mouse embryos. This study was undertaken to construct a system that would allow detection of RNA for the highly glycolytically active subunit (muscletype) of the phosphofructokinase (PFK) enzyme. A muscle specific mutant PFK plasmid was generated to provide mutant internal control RNA. Using this internal control, initial reverse transcriptionpolymerase chain reaction data collected from early embryo stages suggest that the muscle type PFK subunit RNA is not expressed in the preimplantation mouse at the 1-cell or blastocyst stages. This result suggests that PFK activity detected at the later morula and blastocyst stages must be from either a different PFK subunit or a novel embryonic form of PFK.<br>Department of Biology
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Wang, Bin. "Functional studies of QRF-1 /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.
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DesRosiers, Shirley Anne. "The effects of Heligmosomoides polygyrus infection on spatial learning and behaviour of CD-1 male mice in the Morris water maze /." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81324.
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Subclinical infections with the nematode Heligmosomoides polygyrus affect the behaviour and spatial learning of CD-1 mice in a Morris water maze. In early trials testing their ability to find and land on a hidden, submerged platform, uninfected mice displayed normal stress-related behaviours, such as avoiding the central areas of the circular maze and overswimming the platform. Infected mice manifested few such behaviours. Although both acquired the task, there were substantial differences between infected and uninfected mice in their patterns of task acquisition and execution. Although infected mice eventually reached comparable levels of competency, higher cognitive behaviours which suggest familiarity with the location of the platform, such as straight-line swimming, appeared earlier among uninfected mice. Other orientation behaviours, such as paddling and floating, occurred at higher levels among uninfected mice. These behavioural differences are discussed in terms of their adaptive significance to the survival of the host and the transmission of the parasite.
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Pritchard, Colin C. "The molecular program of mouse prostate development /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/5041.
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Burns, Robert. "Comparison of skeletal morphology of Brd2 heterozygous mice against wild type C57/B6J mice." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12302.
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Thesis (M.A.)--Boston University
PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Objectives: The purpose of the study was to characterize age related bone lose in male and female mice lacking one functional copy of the Brd2 gene. These mice will develop age related obesity but will not develop Type II diabetes that is normally associated with obesity. Thus age and sex related changes in the skeletal morphology and structure can be assessed in response to obesity but not be confounded by the development of insulin resistance that is known to effect bone mass.
Methods: Wild type and Brd2 heterozygote male and female mice were allowed to age under normal conditions in which they were fed ad libitum. Skeletal morphology and structure was assessed via µCT of the proximal metaphysis for the trabecular architecture and for the mid-diaphyseal region to assess cortical.
Results: Genotype was found to play a significant role in affecting trabecular architecture in females for BV/TV, connective density, trabecular number, thickness and separation and in males for degree of anisotropy. An age-bygenotype was found to play a significant role in affecting cortical architecture in males for cortical area, total area, cortical area/total area, and medullary area.
Conclusion: Brd2 heterozygote mice have significantly altered structural parameters from that of their wild type counterparts. These differences in how genotype affected the sexes suggests that the Brd2 protein is affected by sex dependent mechanism related to general metabolism and adiposity independent of insulin function.
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Bhanji, Tania. "Elastin in zebrafish and mice." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111938.
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The extracellular matrix is a vital component of the cardiovascular system, in that, it not only provides structural support but also plays a critical role in the maintenance of cellular stability. One of the major components of the vascular matrix is elastin, which confers vessels with the specialized property of stretch and recoil. Elastin deficiency has been implicated in many vascular diseases and determined experimentally to be a negative regulator of smooth muscle cell proliferation. In zebrafish, two elastin genes have been identified, which are actively expressed during development. Based on this finding, protein production and spatial localization for the two elastin proteins was studied by immunohistochemistry with specific antibodies. Results revealed a global distribution for elastin 1 in the ventral aorta and swim bladder, whereas elastin 2 was preferentially localized to the bulbus arteriosus indicating a possible specialized function of elastin 2 in this structure. This observation, and the unique physiological property of this structure, suggests a possible reason for the preservation of both elastin genes during evolution.<br>In the second part of this study, elastin-null mice were studied to uncover the impact of the loss of elastin on the expression of other elastic fiber-associated proteins. The expression of fibrillin-1, the major component of microfibrils, was not altered in the absence of elastin, implying that elastin is not necessary for the formation of microfibrils. On the other hand, both fibulin-2 and -5 were upregulated in the absence of elastin, suggesting that expression of these genes are controlled by elastin. Overall, this study highlights the importance of elastin in evolution, as well as its potential role in the regulation of expression of other matrix molecules.
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Simard, Marie-Chantal. "Nef pathogenesis in transgenic mice." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103182.
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In order to study the functions of SIV Nef in vivo, in a small animal model, transgenic (Tg) mice expressing the SIVmac239 nef gene, under the control of the human CD4 gene promoter (CD4C) were generated. The transgene was found to be expressed in the same cells targeted by the virus, in vivo. These CD4C/SHIV-nef SIV Tg mice develop a severe AIDS-like disease, including premature death, failure to thrive/weight loss, wasting, thymic atrophy, exhibit an especially low number of peripheral CD8+ T cells as well as low number of peripheral CD4+ T cells, diarrhea, splenomegaly, kidney (interstitial nephritis, segmental glomerulosclerosis), lung (lymphocytic interstitial pneumonitis) and heart disease. In addition, these Tg mice fail to mount a class-switched antibody response after immunization with ovalbumin, produce anti-DNA autoantibodies and some of them develop P. Carinii lung infection. These CD4C/SHIV-nefSIV Tg mice develop an AIDS-like disease very similar to that of CD4C/HIV Tg mice, except that the kidney and cardiac diseases were more severe, and that a thymic developmental defect was observed. Heart enlargement was very severe in CD4C/SIV Tg mice during early breeding on the C3H background. Histopathological lesions in the heart of these mice were also multifocal and were similar to those found in CD4C/HIV Tg mice. Data from echocardiography analysis are not yet available for these Tg mice. The low number of peripheral CD8+ and CD4 + T cells likely reflects a thymic defect and may be similar to the DiGeorge-like "thymic defect" immunophenotype described in a subgroup of HIV-1 infected children. Ontogeny studies show that the Tg mice were born with a smaller thymus and that this phenotype is not progressive in nature. As young as embryonic day 17, the thymic absolute cell numbers are lower in the Tg mice when compared to their non-Tg controls and there is a defect in thymocyte maturation in the transition between DN3 and DN4, with a failure to generate normal numbers of DP cells. Fetal liver transplantation studies have ruled out a significant impairment of the thymic epithelium and have suggested that this defect is likely a direct consequence of abnormal T cell progenitors in the thymus.<br>Therefore, it appears that SIV Nef alone expressed in mice, in appropriate cell types and at sufficient levels, can elicit many of the phenotypes of simian and human AIDS. These Tg mice should be instrumental in studying the pathogenesis of SIV Nef-induced phenotypes.
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Argyriou, Catherine. "Enhanced immunity in Mclk1 +/- mice." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117161.
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MCLK1 (a.k.a. COQ7) is an evolutionarily conserved mitochondrial hydroxylase necessary ubiquinone biosynthesis. Mclk1+/- mice display a 50% reduction in this protein, as well as an array of phenotypes including increased longevity, decreased ubiquinone in the inner mitochondrial membrane, decreased mitochondrial respiration, and increased mitochondrial oxidative stress. We report here by various measures that Mclk1+/- mutants also exhibit an enhanced immune response in vivo. That is, Mclk1+/- mice mount a more extreme inflammatory response to bacterial lipopolysaccharide stimulation and bacterial infection, evidenced by increased measures of plasma cytokine levels. These mice also demonstrate resilience to tumour development, evidenced by a prolonged, dose-dependent delay in tumour onset following tumour cell xenograft. Furthermore, we report that Mclk1+/- mice react differently than wild-type mice following rapamycin injection. That is, circulating cytokine levels are attenuated in mutants but increased in wild-type mice following rapamycin administration. Despite their more extreme immune response, we demonstrate that Mclk1+/- mutants sustain less tissue damage as a result of infection or old age. Finally, using mouse models of high mitochondrial or cytoplasmic oxidative stress, we report that the Mclk1+/- phenotype is not simply due to increased reactive oxygen species in the mitochondria. These findings suggest characteristics that may contribute to the increased lifespan of these mice, though the causes of these characteristics require further investigation.<br>MCLK1 (COQ7) est une enzyme hydroxylase conservée au cours de l'évolution et nécessaire pour la biosynthèse de l'ubiquinone. Les souris Mclk1+/- présentent une réduction de 50% du niveau de cette protéine, ainsi qu'une gamme de phénotypes, tels qu'un accroissement de la longévité, une réduction de la quantité d'ubiquinone dans la membrane interne mitochondriale, une réduction de la respiration mitochondriale, et une augmentation du stress oxydatif mitochondrial. Différentes mesures ont démontrées que les souris Mclk1+/- arborent également une meilleure réponse immunitaire suite à la stimulation par des lipopolysaccharides bactériens (LPS) ainsi que par l'infection bactérienne, comme en témoigne une augmentation du niveau de plusieurs cytokines plasmatiques en réponse à ces stimulations. Les mutants Mclk1+/- sont aussi plus résistants au développement de tumeurs, comme en témoigne le délai dans l'apparition de tumeurs après une xénogreffe de cellules tumorales. En outre, nous avons découvert que les souris Mclk1+/- réagissent différemment par rapport aux souris de type sauvage à un traitement avec la rapamycine. Nous avons observé que suite à l'administration prolongée de rapamycine suivi par une injection de LPS, le niveau de cytokines circulantes diminue chez les souris mutantes alors que chez les souris de type sauvage ce niveau augmente. Malgré leur réponse immunitaire plus intense, nous avons démontré que les souris Mclk1+/- subissent moins de dommages tissulaires à la suite d'une infection ou du processus de vieillissement. Enfin, en utilisant des modèles murins de stress oxydatif mitochondrial ou cytoplasmique augmenté, nous avons aussi établi que le phénotype Mclk1+/- ne résulte pas simplement de l'augmentation des radicaux libres dans les mitochondries.
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Dallmann, Robert. "Characterisation of Per mutant mice." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972545263.
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Vara, Piquer Antonio, and Vidal Sebastià A. Verger. "Mice recognition - representation of earprints." Thesis, Halmstad University, School of Information Science, Computer and Electrical Engineering (IDE), 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-2204.
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Goncalves, Nathalie Suzanne. "Citrobacter rodentium infection in mice." Thesis, Queen Mary, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252344.
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Middleton, Sophie Charlotte. "Characterisation of the MICE experiment." Thesis, Imperial College London, 2018. http://hdl.handle.net/10044/1/63880.
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Muon beams of low emittance would deliver intense, well-characterised neutrino beams necessary to explicate the physics of flavour at a Neutrino Factory and for high-luminosity lepton-antilepton collisions at a multi- TeV muon collider. The International Muon Ionisation Cooling Experiment (MICE), based at the Rutherford Appleton Laboratory, aims to demonstrate ionisation cooling, the technique proposed to reduce the emittance of muon beams at such facilities. An ionisation cooling channel has been constructed. The muon beam traverses a low-Z absorber material, losing energy via ionisation. The phase space volume occupied by the beam is reduced, resulting in transverse cooling. This thesis presents two independent analyses accomplished through exploiting data obtained during the “Step IV” commissioning of MICE. Muons can decay within the cooling channel. The presence of electron contaminants within MICE will generate systematic uncertainties on the cooling measurement. The angular distribution of decay electrons is dependent upon the muon polarisation. It is, therefore, imperative to characterise the impact of depolariza- tion in the channel. Chapter 4 presents a unique measurement of the polarisation of the MICE muon beam at the downstream calorimeter. For an initially unpolarised muon beam a polarisation of: -0.021 ± 0.243 (stat.) ± 0.185 (sys.) ± 0.007 (depol.) ± 0.001 (det.) is obtained, appropriately identifying the polarisation of the beam at the point of decay, within acknowledged errors. MICE is devised to possess an on-axis magnetic field. It is paramount that misalignment in the cooling channel is characterised. Chapter 5 ascertains a measurement of the central Focus Coil’s transverse position using single particle transfer matrices. No misalignment of the Focus Coil’s magnetic axis, relative to the beam axis, is observed, within the limits of the analysis. This innovative technique can be employed by any multi-element accelerator system where particle co-ordinates are quantified upon entering and exiting a constituent magnet.
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Opsahl, Margaret L. "Variegated transgene expression in mice." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/12735.
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This thesis investigates expression instability, focusing on mice carrying a transgene encoding sheep β-lactoglobulin (BLG), the major whey protein BLG transgenes inserted as multicopy arrays within the mouse genome are robustly expressed in mammary epithelium and the product is exported into milk (Simons <i>et al</i> 1987). In two of the three lines studied, milk BLG levels differed markedly between individuals. This was attributed to mosaic expression due to stochastic inactivation of the transgene (Dobie <i>et al</i> 1996), and suggestive of position effect variegation as seen in <i>Drosophila. </i>The highly variegating line, BLG/7, was chosen for further studies. The original line was created on a mixed genetic background. First, to address a possible link between genetic background and variegation, BLG/7 animals were backcrossed to inbred mouse strains CBA and C57BL/6. Transgene expression continued to variegate after 13 backcross generations. However, inbreeding reduced the absolute expression levels: the mean and variance differed significantly from the parental population. Levels were restored by intercrossing inbred strains. Second, homozygous BLG/7 mice were studied. Variegated expression was maintained, but maximum expression levels were indistinguishable from heterozygote levels. Fluorescent <i>in situ</i> hybridisation for nuclear BLG transcription revealed that only one transgene locus is active per cell. This is suggestive of a <i>trans-</i>homology effect for the BLG/7 transgene. Previously, similar events have only been reported in plants and insects. Finally, mosaic expression could reflect clonal expansion of committed progenitor cells. To address this issue, we sought to exploit X-inactivation. A lacZ reporter gene under BLG promoter control was targeted to the X-linked hypoxanthine-xanthine phosophoribosyl transferase (HPRT) gene of ES cells. To date, chimeric animals have been obtained.
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Zohar, Alexandra Simona. "Behavioural changes in Trichinella spiralis-infected mice." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65514.
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Chen, Hao Hang Rachel. "The effect of pandemic influenza H1N1 viral infection on house dust mite sensitized mice." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58438.
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A disproportionately large number of asthmatics experienced morbidity and mortality during the 2009 H1N1 pandemic. To date, there is little information on the mechanisms behind this epidemiological and clinical observation. Using a murine asthma model, we sought to determine the effects of airway inflammation on host responses to pandemic H1N1 (pH1N1) infection. We hypothesized that mice with an allergic airway phenotype would have a greater viral susceptibility to pH1N1 infection and a dysregulated host response that prevents effective viral clearance and leads to increased burden of pulmonary inflammation, resulting in poor clinical outcomes. We established a murine allergic airway model using house dust mite (HDM) extract. We intranasally instilled male BALB/c mice with HDM or sham PBS daily for two weeks; after which we introduced a single intranasal dose of pH1N1 virus or control vehicle fluid (CAF). HDM or PBS instillation continued daily post-viral infection (pi) forming four groups: 1) sham-sensitized + CAF, 2) HDM-sensitized + CAF, 3) sham-sensitized + pH1N1, and 4) HDM-sensitized + pH1N1. Mice were weighed daily. Virus-infected animals were euthanized at 1-hr pi and on Day 1, 2, 4, 5, 6, and 8 pi and non-infected animals were euthanized on Day 0 and 8 pi. Viral titre, interferon-β (IFN β), and interferon-stimulated gene (ISG) expression patterns were determined by qPCR on RNA extracted from homogenized lung tissue. IFN β protein levels were evaluated by ELISA in bronchoalveolar lavage. Pulmonary inflammation was quantified using H&E stain on formalin-fixed paraffin-embedded lung tissue. HDM-sensitized animals exhibited significantly greater weight loss than sham-sensitized animals following infection. Also, HDM-sensitized mice had significantly higher viral titres on Day 8 pi as compared to sham-sensitized mice. Downstream ISG inductions were dampened in HDM-sensitized, virus-infected animals despite comparable initial IFN β response in HDM- and sham-sensitized mice. We also observed mixed-type pulmonary inflammation in HDM-sensitized mice following pH1N1 infection. Our data suggest dysregulated host ISG responses, combined with the overwhelming burden of pulmonary inflammation, contribute to impaired viral clearance and weight loss indicative of detrimental health outcomes in animals sensitized with HDM following pH1N1 infection.<br>Medicine, Faculty of<br>Experimental Medicine, Division of<br>Medicine, Department of<br>Graduate
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McClellan, Kelly Anne. "Murine oocyte loss occurs during fetal development." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79047.
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Recently, the timing of oocyte loss during murine development has been brought into question as authors using mouse vasa homologue (MVH) as a germ cell marker did not observe a loss of oocytes during fetal life. Instead the major loss was observed in the days following birth, after chromosome pairing has occurred.<br>In this study the controversy was addressed by establishing a new and reliable method to quantify murine oocytes in meiotic prophase, as well as to determine the gestation age and meiotic prophase stage of oocyte loss. Earlier limitations were overcome through the use of Germ Cell Nuclear Antigen-1 (GCNA-1) antibody as a germ cell specific marker, and the novel addition of a cytospin centrifugation step to the method. Progress through meiotic prophase was examined in chromosome spread preparations where meiotic stages were assessed using an antiserum against synaptonemal complex (SC) proteins. Quantification was accomplished by counting the number of GCNA-1 immunoreactive cells in chromosome spread preparations and estimated in histological sections using the ratio estimation model. (Abstract shortened by UMI.)
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Kim, Iksoo Phillips Carleton J. "Gene flow, genetic population structure, and biogeography of the leaf-eared mouse, Phyllotis xanthopygus, dwelling in natural habitat islands." Normal, Ill. Illinois State University, 1998. http://wwwlib.umi.com/cr/ilstu/fullcit?p9835913.
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Thesis (Ph. D.)--Illinois State University, 1998.<br>Title from title page screen, viewed July 5, 2006. Dissertation Committee: Carleton J. Phillips (chair), Elmer C. Birney, Angelo P. Capparella, Sabine S. Loew, Charles F. Thompson. Includes bibliographical references (leaves 61-74) and abstract. Also available in print.
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Filipovska-Naumovska, Emilija. "Development of methods for detection and eradication of mouse parvovirus from a laboratory mouse colony." Filipovska-Naumovska, Emilija (2007) Development of methods for detection and eradication of mouse parvovirus from a laboratory mouse colony. PhD thesis, Murdoch University, 2007. http://researchrepository.murdoch.edu.au/676/.
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The mouse parvovirus designated MPV can infect laboratory mice and affect the humoral and cellular immune response of infected mice, reducing their value for biomedical and medical research. The development and maintenance of MPV-free mouse colonies for biomedical research is therefore essential and requires routine monitoring of the infection status of mice, using serological surveillance procedures.
Recent experience in the Animal Resources Centre (ARC), a major supplier of mice to the medical research community in Australia, was that MPV infection was present but was not detectable with the serological tests that were then in routine use.
This thesis reports the development of a polymerase chain reaction (PCR) assay for the detection of the MPV in the ARC mouse colonies, the genetic characteristics of the strain of MPV detected, the development of a recombinant virus protein that provided a suitable antigen for enzyme-linked immunosorbent assay (ELISA) and a Western immunoblot (WIB) assay for the detection of MPV antibodies, and use of these various assays to determine aspects of the epidemiology and pathogenicity of the infection that were critical to the eradication of virus infection and future immunological surveillance to ensure the absence of infection.
The recombinant protein produced as an antigen was a biotinylated fusion protein, a truncated capsid protein of the strain of MPV detected in the ARC, and was produced using the PinpointTM vector and with expression in Escherichia coli. The protein was produced as an insoluble intracellular product within inclusion bodies and was solubilised using urea and purified. The purified protein was utilised as an antigen for ELISA and the WIB assays to detect virus antibody in infected mice.
The outbreak of MPV infection in the ARC was used as an unique opportunity for assessment of the seroprevalence of MPV-1 infection in a large laboratory mouse colony and to utilise this data to determine the sampling size needed to reliably detect MPV-1 infection within such large laboratory mouse colonies. An overall seroprevalence of 16.5% was detected using the developed serological tests, but considerable variation in prevalence was detected in different mouse strains.
The response to MPV infection of 4 different but common strains of mice was determined as a basis for developing appropriate surveillance procedures and the selection of appropriate sentinel animals. The effect of infection of these strains at different ages was also investigated. Virus replication was detected in tissues of all the mice strains infected (outbred ARC(s) and inbred C57BL/6JArc, BALB/c and BALB/c-Foxn1nu/Arc) as juveniles and adults, with the exception of C57BL/6JArc inoculated as adults. However, while seroconversion in mice inoculated as juveniles and adults was detected in ARC(s) and C57BL/6JArc mice, it was not detected in BALB/c mice. The high rate of seroconversion to MPV, the early and prolonged development of an immune response, and the lack of age differences in their susceptibility indicated that ARC(s) mice would provide reliable sentinels for the detection of MPV.
The genomic nucleotide sequence of the ARC strain, excluding the terminal palindromic regions and the predicted amino acid sequences of the non-structural and structural proteins was determined. This strain was very similar (98-99% nucleotide identity) to the previously described MPV strains MPV-1a, MPV-1b and MPV -1c. The similarity suggested there were unlikely to be significant antigenic differences in the proteins of the ARC strain and those strains of MPV reported previously.
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Laing, Michael A. "Establishing the role of PEA3 : an ETS family transcription factor, during mouse embryonic development /." *McMaster only, 1998.
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Parviz, Maryam Gross Guenter W. "Evaluation of zinc toxicity using neuronal networks on microelectrode arrays response quantification and entry pathway analysis /." [Denton, Tex.] : University of North Texas, 2007. http://digital.library.unt.edu/permalink/meta-dc-3928.
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Hsu, Charlie Chun. "Isolation, characterization, and diagnosis of murine noroviruses, a newly recognized pathogen of mice." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4790.
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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>"December 2007" The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. Includes bibliographical references.
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Guan, Dongming Loew Sabine Susanne. "Fitness, developmental stability, and germline mutation rates in white-footed mice (Peromyscus leucopus) chronically exposed to heavy metal contamination." Normal, Ill. : Illinois State University, 2007. http://proquest.umi.com/pqdweb?index=0&did=1414115231&SrchMode=1&sid=4&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1207663717&clientId=43838.
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Thesis (Ph. D.)--Illinois State University, 2007.<br>Title from title page screen, viewed on April 8, 2008. Dissertation Committee: Sabine S. Loew (chair), Steven A. Juliano, Charles F. Thompson, Angelo P. Capparella, William L. Perry. Includes bibliographical references (leaves 143-173) and abstract. Also available in print.
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Cheong, Wan-yee Ana. "Regulation and characterization of microsomal epoxide hydrolase (Ephx1) in the female reproductive tract /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38284182.
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Jeffries, Sean Joseph. "Imprint erasure and DNA demethylation in mouse development." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608949.
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La, Eunhye. "The regulation of the interleukin 1 receptor antagonist in mouse skin carcinogenesis /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.
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Yau, Tai-on. "Regulation of the mouse hoxb-3 gene in the neural expression domains during embryogenesis." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23426147.
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