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Journal articles on the topic 'Michaels, Shawn'

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Published: 4 June 2021

Last updated: 4 February 2022

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1

Leontakianakou, Irini. "A post-Byzantine creation: The archangel Michael triumphant and psychopomp." Zograf, no. 33 (2009): 145–58. http://dx.doi.org/10.2298/zog0933143l.

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This paper deals with a specific iconographic type of Archangel Michael: he is shown bearing a soul in the form of a swaddled infant, while subduing an old man who is wearing only a loincloth. Who is Michael subduing? Three possible answers are considered: 1) the figure can be identified with Satan the fallen angel who, like Michael, has an immaterial nature and is commonly considered as his enemy par excellence; 2) he can also be an anonymous sinner, whose soul is depicted in Michael's hand; 3) finally, one could identify him with Hades, the god of the Underworld and personification of death, because he is depicted as an old man, semi-nude with a pronounced musculature, as well as because of the assimilation of Michael to God. Rather than making a single choice, the author proposes a combined interpretation of the image, which allows for the integration of all the aspects of Michael's cult (military, triumph over Satan, psychopomp, archangel of the Last Judgment) and unifies the past (the fall of Satan), the present (death of a sinner) and the future (Last Judgment).

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2

Matthews, Jo. "The coaching toolkit - By Shaun Allison & Michael Harbour." British Journal of Educational Technology 40, no. 6 (November 2009): 1142. http://dx.doi.org/10.1111/j.1467-8535.2009.01026_1.x.

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3

Holroyd, Michael. "Excerpt from Michael Holroyd's Biography of George Bernard Shaw." Chesterton Review 24, no. 4 (1998): 533–41. http://dx.doi.org/10.5840/chesterton1998244107.

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4

Demoor, Marysa. "Michael Holroyd, "Bernard Shaw. The Lure of Fantasy, 1918-1950."." Documenta 11, no. 2 (April 10, 2019): 116–19. http://dx.doi.org/10.21825/doc.v11i2.10590.

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5

Demoor, Marysa. "Michael Holroyd, Bernard Shaw. Vol. II: The Pursuit of Power." Documenta 8, no. 4 (May 3, 2019): 220–23. http://dx.doi.org/10.21825/doc.v8i4.11080.

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6

Hazelton, Andrew T., Xuejin Zhang, Sundararaman Gopalakrishnan, William Ramstrom, Frank Marks, and Jun A. Zhang. "High-Resolution Ensemble HFV3 Forecasts of Hurricane Michael (2018): Rapid Intensification in Shear." Monthly Weather Review 148, no. 5 (April 17, 2020): 2009–32. http://dx.doi.org/10.1175/mwr-d-19-0275.1.

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Abstract The FV3GFS is the current operational Global Forecast System (GFS) at the National Centers for Environmental Prediction (NCEP), which combines a finite-volume cubed sphere dynamical core (FV3) and GFS physics. In this study, FV3GFS is used to gain understanding of rapid intensification (RI) of tropical cyclones (TCs) in shear. The analysis demonstrates the importance of TC structure in a complex system like Hurricane Michael, which intensified to a category 5 hurricane over the Gulf of Mexico despite over 20 kt (10 m s−1) of vertical wind shear. Michael’s RI is examined using a global-nest FV3GFS ensemble with the nest at 3-km resolution. The ensemble shows a range of peak intensities from 77 to 159 kt (40–82 m s−1). Precipitation symmetry, vortex tilt, moisture, and other aspects of Michael’s evolution are compared through composites of stronger and weaker members. The 850–200-hPa vertical shear is 22 kt (11 m s−1) in the mean of both strong and weak members during the early stage. Tilt and moisture are two distinguishing factors between strong and weak members. The relationship between vortex tilt and humidification is complex, and other studies have shown both are important for sheared intensification. Here, it is shown that tilt reduction leads to upshear humidification and is thus a driving factor for intensification. A stronger initial vortex and early evolution of the vortex also appear to be the key to members that are able to resist the sheared environment.

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7

Wilmeth, Don B. "The Sidney P. Albert-Bernard Shaw Collection." Theatre Survey 42, no. 2 (November 2001): 215–22. http://dx.doi.org/10.1017/s0040557401000114.

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In November 1991, Brown University announced the addition of the Sidney P. Albert-G. B. Shaw Collection to its Special Collections. The purchase of the private collection of Sidney P. Albert was accomplished with the support and encouragement of the then president of Brown, Vartan Gregorian. At the same time, and upon Albert's recommendation, Brown acquired the correspondence and other documents relating to Shaw's dealings with his American publisher, Dodd, Mead & Company (and, by extension, other publishers). An inaugural exhibit of material from the Albert Collection (“Quintessential Shaw”) was mounted in Brown's John Hay Library, 5 May –28 July, 1995, curated by former Brown Curator for Printed Books, Jennifer Lee. To celebrate the opening of the exhibit and to mark the addition of the Albert-Shaw Collection to Brown's holdings, the Friends of Brown Library hosted a dinner-reception on 5 May with readings from Shaw plays and a brief talk (“100 Years Ago: G.B.S. in 1895”) by Albert, followed by a public lecture (“Shaw's Utopia”) delivered by Shaw biographer Michael Holroyd.

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8

Kempna-Pieniążek, Magdalena. "Terytorium rezu. Symbolika oraz kulturowe konteksty krajobrazu indiańskiego rezerwatu we współczesnym północnoamerykańskim kinie i komiksie." Annales Universitatis Paedagogicae Cracoviensis | Studia de Cultura 9, no. 4 (June 29, 2018): 30–38. http://dx.doi.org/10.24917/20837275.9.4.3.

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DOI 10.24917/20837275.9.4.3Ubogie domostwa, rozsiane po pustkowiu przyczepy zamieszkane przez zdegenerowanych ludzi, pokryte kurzem drogi, po których poruszają się zdezelowane samochody – pejzaż indiańskiego rezerwatu we współczesnej kulturze audiowizualnej naznaczony jest świadectwami upadku. Równocześnie jednak przestrzeń, w której tak wyraziście manifestują się liczne problemy społeczne, na czele z alkoholizmem oraz bezrobociem, stanowi część dyskursów dotyczących marginalizacji, nietolerancji, alienacji i społecznej stygmatyzacji. Filmowy i komiksowy pejzaż „rezu” stanowi krzywe zwierciadło oficjalnej amerykańskiej kultury, symbolizowanej przez Mount Rushmore, w której cieniu kryje się rezerwat plemienia Lakota w Pine Ridge. Analizując wybrane przykłady filmowe oraz komiksowe, autorka ukazuje różne aspekty symboliki i kulturowych kontekstów „rezu”. Z jednej strony – w filmach takich jak Skins Chrisa Eyre’a lub Za głosem serca Michaela Apteda oraz w komiksowej serii Skalp Jasona Aarona i R.M. Guéry – mamy do czynienia z wizją rezerwatu stanowiącego krajobraz nieomalże apokaliptyczny, utożsamiający ciemną stronę Ameryki; z drugiej – w realizacjach pokroju Sygnałów dymnych Eyre’a czy Piętna przodków Michaela Linna – rezerwat jawi się jako przestrzeń mityczna, obszar kontaktu ze wcześniejszymi pokoleniami.Rez territory. Symbols and cultural contexts of Indian reservation landscape in contemporary Northern American cinema and comic booksPoor houses, trailers scattered in wilderness, inhabited by degenerated people, dusty roads full of old cars – the landscape of Indian reservation in contemporary audiovisual culture is marked with symptoms of degradation. In the same time, places where social problems – especially alcoholism and unemployment – have been so vividly manifested, become a part of various discourses of marginalization, intolerance, alienation and social stigmatization. “Rez’s” landscape in film and comic books becomes a dark mirror for the official American culture symbolized by Mount Rushmore, in whose shadow lies the Lakota Pine Ridge reservation. In her analysis of selected films and comic books, theauthor shows different aspects of rez’s symbols and cultural contexts. In such films as Chris Eyre’s Skins or Michael Apted’s Thunderheart and Jason Aaron and R.M. Guéra’s comic book series Scalped, Indian reservation is shown almost as an apocalyptic territory and – in the same time – as a dark side of America. On the other hand, in Eyre’s Smoke Signals or Michael Linn’s Imprint, rez is a mythic place of cross-generation encounters.

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9

Filobello-Nino, U., H. Vazquez-Leal, R. Castaneda-Sheissa, V. M. Jimenez-Fernandez, A. L. Herrera-May, J. Huerta-Chua, L. Gil-Adalid, and J. E. Pretelin-Canela. "An Analytical Approximate Solution for the Quasi-Steady State Michaelis-Menten Problem." Discrete Dynamics in Nature and Society 2019 (March 27, 2019): 1–9. http://dx.doi.org/10.1155/2019/8901508.

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This article utilizes perturbation method (PM) to find an analytical approximate solution for the Quasi-Steady-State Michaelis-Menten problem. From the comparison of Figures and absolute error values, between approximate and numerical solutions, it is shown that the obtained solutions are accurate, and therefore, they explain the general behaviour of the Michaelis-Menten mechanism.

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10

Sumner, James. "Michael Combrune, Peter Shaw and Commercial Chemistry: the Boerhaavian Chemical Origins of Brewing Thermometry." Ambix 54, no. 1 (March 2007): 5–29. http://dx.doi.org/10.1179/174582307x165452.

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11

Murray, Isobel. ""Bernard Shaw, Volume 1, 1856-1898: The Search for Love," by Michael Holroyd; and "Bernard Shaw: Collected Letters 1926-1950," ed. Dan H. Laurence." Chesterton Review 15, no. 3 (1989): 381–87. http://dx.doi.org/10.5840/chesterton198915316.

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12

Davis, Aaron B., Rachel E. Lambert, Frank R. Fronczek, Peter J. Cragg, and Karl J. Wallace. "An activated coumarin-enamine Michael acceptor for CN−." New J. Chem. 38, no. 10 (2014): 4678–83. http://dx.doi.org/10.1039/c4nj00862f.

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13

Chappell, Richard L., and Ken-Ichi Naka. "Sensitivity transformation for vertebrate vision." Visual Neuroscience 6, no. 4 (April 1991): 371–74. http://dx.doi.org/10.1017/s0952523800006593.

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AbstractThe visual response to a flash given in the dark is known to saturate according to the Michaelis-Menten relationship. Nevertheless, the incremental response from increasing levels of mean luminance tends to follow a Weber-Fechner relationship well into the saturation range determined from the Michaelis-Menten results. This sensitivity transformation from Michaelis-Menten to Weber-Fechner is an important characteristic of light adaptation in the vertebrate retina. Recent studies concerning the role of calcium in photoreceptor adaptation have shown that the relaxation from peak to plateau in the response of isolated photoreceptors was absent under conditions in which adaptation was blocked. Comparing the pronounced relaxation from peak to plateau in turtle horizontal cells with the absence of such relaxation in the catfish response, we noted also that turtle incremental sensitivity shows a Weber-Fechner relationship while catfish incremental sensitivity more closely follows the local slope of the Michaelis-Menten relation. Based on these observations, we have obtained an expression to relate the relaxation from peak to plateau with the sensitivity transformation. We assume that adaptation shifts the half-maximum point of the Michaelis-Menten curve so that the light response relaxes to a plateau value equal to a specified fraction φ of the peak response. We show that this manipulation alone results in a transformation from Michaelis-Menten kinetics to Weber-Fechner sensitivity.

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14

Castro-Osma, José A., James W. Comerford, Samantha Heath, Oliver Jones, Maria Morcillo, and Michael North. "Quinine catalysed asymmetric Michael additions in a sustainable solvent." RSC Advances 5, no. 5 (2015): 3678–85. http://dx.doi.org/10.1039/c4ra12132e.

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15

Gabelic, Smiljka. "From the painted programme of Saint John (Ayvali Kilise), Cssappadocia." Zograf, no. 33 (2009): 33–41. http://dx.doi.org/10.2298/zog0933033g.

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In the Church of St. John in Cappadocia, also known as Ayvali Kilise or Gulu dere 4, on the frescoes which were painted between 913 and 920, particular devotion was shown for the cult of the archangels. The two archangels Michael and Gabriel, were painted in very large dimensions, with inscriptions describing them as 'great', besides giving their names. In addition to that a unique group of two figures was presented. It depicted the monk Archippos turned toward a colossal figure of the archangel Michael, painted strictly frontally. The iconographical relationship of these two figures, unrecorded in scholarly literature, indicates that this was definitely Archippos, the custodian of the important shrine of the Archangel Michael at Chonai, which still existed in those times. This would not only be a very early, but the only preserved presentation of Archippos, other than his appearance in the well-known composition of the Miracle of the Archangel Michael at Chonai.

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16

Nájera, Carmen, José Miguel Sansano, and Enrique Gómez-Bengoa. "Heterocycle-based bifunctional organocatalysts in asymmetric synthesis." Pure and Applied Chemistry 88, no. 6 (June 1, 2016): 561–78. http://dx.doi.org/10.1515/pac-2016-0403.

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AbstractDifferent chiral bifunctional organocatalysts derived from trans-cyclohexane-1,2-diamine bearing different types of guanidine units able to form-hydrogen bonding activation have been designed. Conformational rigid 2-aminobenzimidazoles bearing a tertiary amino group have been used in enantioselective Michael type reactions of activated methylene compounds to nitroalkenes. The C2 symmetric bis(2-aminobenzimidazole) derivatives the appropriate organocatalyst for the conjugate addition of 1,3-dicarbonyl compounds to maleimides as well as for the SN1 reaction of benzylic alcohols with carbon nucleophiles. 2-Aminobenzimidazoles bearing a primary amino group have shown excellent catalytic activity in the Michael reaction of aldehydes to maleimides and nitroalkenes. Diastereomeric 2-aminopyrimidines bearing a prolinamide unit have been incorporated in the trans-cyclohexane-1,2-diamine scaffold and have been used for the inter- and intra-molecular direct aldol reaction under solvent-free conditions. For the Michael reaction of aldehydes with maleimides the primary amine 2-aminopyrimidine has shown excellent efficiency as organocatalyst. The bifunctional character of these organocatalysts has been demonstrated by means of DFT calculations.

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17

Lazic, Jelena, Jelena Spasic, Djordje Francuski, Zorana Tokic-Vujosevic, Jasmina Nikodinovic-Runic, Veselin Maslak, and Lidija Djokic. "Importance of the N-terminal proline for the promiscuous activity of 4-oxalocrotonate tautomerase (4-OT)." Journal of the Serbian Chemical Society 81, no. 8 (2016): 871–81. http://dx.doi.org/10.2298/jsc160222053l.

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Michael addition of aldehydes to nitroolefins is an effective method to obtain useful chiral ?-nitroaldehydes. ?-Nitroaldehydes are precursors for chiral ?-aminobytiric acid analogues which have numerous pharmacological activities and are used for treatment of neurological disorders. A whole-cell system based on recombinantly expressed 4-oxalocrotonate tautomerase (4-OT) has been developed and shown to be an effective biocatalyst for Michael addition of branched aldehydes to ?-nitrostyrenes. The aim of this study was to investigate the influence of the substitution of the N-terminal proline with lysine and arginine both containing the reactive ?-amino group, on the Michael addition catalyzed by 4-OT. Firstly, the effect of these mutations was examined by in silico analysis, followed by generation of three terminal ly-sine mutants. The generated mutants, 4-OT_K, 4-OT_PK and 4-OT_KK were tested for the ability to utilise ?-nitrostyrene (1), (E)-2-(thiophene-2-yl)nitroethen (2) and p-chloro-trans-?-nitrostyrene (3) as Michael acceptors with isobutanal as the donor. For comparison, the lithium salt of lysine was used in the same organocatalytic reactions. In general, the introduction of lysine had a negative effect on Michael additions based on overall product yields. However, additional lysine residues at the N-terminus of the protein resulted in structural changes that enhanced the activity towards 2 and 3. Therefore, the N-terminal proline is important for the 4-OT catalysed Michael-additons, but it is not essential.

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18

Millius, Arthur, Koji L. Ode, and Hiroki R. Ueda. "A period without PER: understanding 24-hour rhythms without classic transcription and translation feedback loops." F1000Research 8 (April 16, 2019): 499. http://dx.doi.org/10.12688/f1000research.18158.1.

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Since Ronald Konopka and Seymour Benzer’s discovery of the genePeriodin the 1970s, the circadian rhythm field has diligently investigated regulatory mechanisms and intracellular transcriptional and translation feedback loops involvingPeriod, and these investigations culminated in a 2017 Nobel Prize in Physiology or Medicine for Michael W. Young, Michael Rosbash, and Jeffrey C. Hall. Although research on 24-hour behavior rhythms started withPeriod, a series of discoveries in the past decade have shown us that post-transcriptional regulation and protein modification, such as phosphorylation and oxidation, are alternatives ways to building a ticking clock.

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19

UshaRani, Ramu, Lakshmanan Rajendran, and Marwan Abukhaled. "Approximations for the Concentration and Effectiveness Factor in Porous Catalysts of Arbitrary Shape: Taylor Series and Akbari-Ganji’s Methods." Mathematical Modelling of Engineering Problems 8, no. 4 (August 31, 2021): 527–37. http://dx.doi.org/10.18280/mmep.080405.

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A mathematical model of reaction-diffusion problem with Michaelis-Menten kinetics in catalyst particles of arbitrary shape is investigated. Analytical expressions of the concentration of substrates are derived as functions of the Thiele modulus, the modified Sherwood number, and the Michaelis constant. A Taylor series approach and the Akbari-Ganji's method are utilized to determine the substrate concentration and the effectiveness factor. The effects of the shape factor on the concentration profiles and the effectiveness factor are discussed. In addition to their simple implementations, the proposed analytical approaches are reliable and highly accurate, as it will be shown when compared with numerical simulations.

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20

Nehlig, E., L. Motte, and E. Guénin. "Magnetic nano-organocatalysts: impact of surface functionalization on catalytic activity." RSC Advances 5, no. 127 (2015): 104688–94. http://dx.doi.org/10.1039/c5ra20644h.

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Nano-organocatalysts were synthesized using controlled click chemistry and studied in aldolization and Michael addition reactions. It was shown that small modifications of the nanosurface can have a drastic effect on the catalysis.

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21

Moor, Marysa De. "Michael Holroyd. Bernard Shaw. Vol. I 1856-1898. The search for Love. A biography. New York 1988." Documenta 7, no. 3 (May 3, 2019): 172–74. http://dx.doi.org/10.21825/doc.v7i3.11040.

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22

Burke, John Francis. "Social Justice Isn’t What You Think It Is by Michael Novak & Paul Adams with Elizabeth Shaw." American Catholic Studies 127, no. 4 (2016): 80–82. http://dx.doi.org/10.1353/acs.2016.0065.

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23

Madung, Otto Gusti. "Krisis Demokrasi dan Tirani Meritokrasi Menurut Michael Sandel." Jurnal Ledalero 19, no. 2 (December 19, 2020): 127. http://dx.doi.org/10.31385/jl.v19i2.212.127-144.

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<p><em>This article aims to introduce the basic thesis of Michael Sandel as described in the book the Tyranny of Merit about the link between the contemporary crisis of democracy and meritocracy. The crisis of democracy today is shown through the increasing wave of right-wing populism in some democratic countries in Europe and the USA. According to Michael Sandel, the crisis of democracy is caused by the policy of meritocracy launched by the liberal democracy that has marginalized the groups of the middle class and working class. Furthermore, the article argues that populist leaders such as Donald Trump succeed in capitalizing on the grievances and frustration of social groups and expressing them as a political agenda. Based on the communitarianism of Michael Sandel, this article offers a solution to strengthen the role of social solidarity and community to cope with individualism and the crisis of liberal democracy. </em></p><p><strong>Key words</strong>:<em> Crisis of democracy, meritocracy, liberalism, communitaranism, Michael Sandel.</em></p>

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24

Kayal, Satavisha, and Santanu Mukherjee. "Catalytic enantioselective cascade Michael/cyclization reaction of 3-isothiocyanato oxindoles with exocyclic α,β-unsaturated ketones en route to 3,2′-pyrrolidinyl bispirooxindoles." Organic & Biomolecular Chemistry 14, no. 43 (2016): 10175–79. http://dx.doi.org/10.1039/c6ob02187e.

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Cascade Michael/cyclization reactions between 3-isothiocyanato oxindoles and exocyclic α,β-unsaturated ketones are shown to proceed in the presence of a tertiary amino-squaramide catalyst and furnish 3,2′-pyrrolidinyl bispirooxindoles with excellent enantioselectivities (up to 99 : 1 er).

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25

Chigogidze, Alex. "Continuous homomorphisms of Arens-Michael algebras." International Journal of Mathematics and Mathematical Sciences 2003, no. 19 (2003): 1215–31. http://dx.doi.org/10.1155/s0161171203012237.

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It is shown that every continuous homomorphism of Arens-Michael algebras can be obtained as the limit of a morphism of certain projective systems consisting of Fréchet algebras. Based on this, we prove that a complemented subalgebra of an uncountable product of Fréchet algebras is topologically isomorphic to the product of Fréchet algebras.

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26

Gunaratne, H. Q. Nimal, P. Nockemann, and K. R. Seddon. "Ionic liquids for efficient hydrogen sulfide and thiol scavenging." Green Chem. 16, no. 5 (2014): 2411–17. http://dx.doi.org/10.1039/c3gc42463d.

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Functionalised pyridinium and ammonium ionic liquids bearing a Michael acceptor are shown to scavenge H₂S gas and various thiols, in most cases, without the aid of any added bases. Utilising the effective non-volatility of ionic liquids and ‘tagging’ malodourous substances to an ionic matrix renders them odourless.

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27

Han, Zhao, and Xufeng Lin. "Synthesis of Chiral Tertiary Amine–Thioureas Based on Spirobiindane and Application in Catalytic Asymmetric Michael Addition Reaction." Synthesis 52, no. 07 (February 4, 2020): 1131–39. http://dx.doi.org/10.1055/s-0039-1691643.

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A series of novel chiral bifunctional tertiary amine–thioureas based on spirobiindane were designed and synthesized as organocatalysts. One of these catalysts was shown to promote the asymmetric Michael addition reaction of 1,3-diphenylpropane-1,3-dione to nitroolefins, affording the desired products in good yields (up to 95%) and enantioselectivities (up to 98% ee).

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Howles, Tim. "Shaun C. Henson and Michael J. Lakey, Academic Vocation in the Church and Academy Today: ‘And With All Of Your Mind’." Theology 121, no. 1 (January 2018): 50–51. http://dx.doi.org/10.1177/0040571x17730983.

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Meredith, D., and C. A. Boyd. "Dipeptide transport characteristics of the apical membrane of rat lung type II pneumocytes." American Journal of Physiology-Lung Cellular and Molecular Physiology 269, no. 2 (August 1, 1995): L137—L143. http://dx.doi.org/10.1152/ajplung.1995.269.2.l137.

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The transport of a hydrolysis-resistant dipeptide, D-phenylalanyl-L-alanine (D-Phe-L-Ala), has been studied by high-performance liquid chromatography in rat lung epithelial cells and apical membrane vesicles. Time-dependent uptake of D-Phe-L-Ala into isolated type II pneumocytes was shown. Uptake was saturable, and Michaelis-Menten kinetics were fitted to the data and gave an apparent Michaelis constant (Km) of 3.4 mM and a maximum velocity (Vmax) of 7.0 nmol.mg protein-1.min-1. However, known peptide transport inhibitors unexpectedly increased intracellular D-Phe-L-Ala concentration when initial rates of peptide uptake were studied. Apical (brush-border) membrane vesicles prepared from rat lung also showed time- and concentration-dependent influx of D-Phe-L-Ala (apparent Km 2.0 mM, Vmax 0.53 nmol.mg protein-1.min-1). Influx of this neutral dipeptide into the vesicles was shown to be both electrogenic and stimulated by an inwardly directed proton gradient. Influx was inhibitable by mercuric chloride and by the amino acid residue modifying compounds N-acetylimidazole and diethylpyrocarbonate. These findings strongly suggest the presence of a proton-coupled peptide transport protein in the apical surface of the type II cell. This transporter may play a role in lung homeostasis.

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30

Willis, Frank N., and Michael Henderson. "Names Associated with Attractiveness." Psychological Reports 74, no. 3_suppl (June 1994): 1275–79. http://dx.doi.org/10.2466/pr0.1994.74.3c.1275.

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Desirable names have been shown to be related to a variety of positive characteristics. The present study was designed to assess agreement on names associated with attractiveness. Participants listed five names which they associated with each of the following: attractive females, attractive males, unattractive females, and unattractive males. With the exception of the name Michael for attractive males, there was little evidence of agreement for attractive and unattractive names. There were few differences in the frequencies of names listed in relation to the age, gender, or income of the participants. Michael was also among the top ten most often used baby names for Kansas, Missouri, and Texas in 1992. Only a few of the other top ten names in our samples were also among the top ten baby names for the three states. Names associated with attractiveness are not necessarily currently popular names for babies.

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Kincaid, Arthur. "Thomas More in The Tudors, shown on BBC-TV (co-production of Peace Arch, Showtime and Working Title, script by Michael Hirst)." Moreana 45 (Number 175), no. 3 (December 2008): 242–46. http://dx.doi.org/10.3366/more.2008.45.3.14.

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32

de Freitas Silva, Matheus, Letizia Pruccoli, Fabiana Morroni, Giulia Sita, Francesca Seghetti, Claudio Viegas, and Andrea Tarozzi. "The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones." Molecules 23, no. 7 (July 20, 2018): 1803. http://dx.doi.org/10.3390/molecules23071803.

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Chalcones have shown a broad spectrum of biological activities with clinical potential against various diseases. The biological activities are mainly attributed to the presence in the chalcones of the α,β-unsaturated carbonyl system, perceived as a potential Michael acceptor. Chalcones could activate the Kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway through a Michael addition reaction with the cysteines of Keap1, which acts as a redox sensor and negative regulator of Nrf2. This modification allows the dissociation of Nrf2 from the cytoplasmic complex with Keap1 and its nuclear translocation. At this level, Nrf2 binds to the antioxidant response element (ARE) and activates the expression of several detoxification, antioxidant and anti-inflammatory genes as well as genes involved in the clearance of damaged proteins. In this regard, the Keap1/Nrf2–ARE pathway is a new potential pharmacological target for the treatment of many chronic diseases. In this review we summarize the current progress in the study of Keap1/Nrf2–ARE pathway activation by natural and synthetic chalcones and their potential pharmacological applications. Among the pharmacological activities highlighted, anti-inflammatory activity was more evident than others, suggesting a multi-target Michael acceptor mechanism for the chalcones involving key regulators of the Nrf2 and nuclear factor- κB (NF-κB) pathways.

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Bill Rowe. "The Thread: Commentary on Shaw, Scheel, and Gardner's Review of Michael Tomasello's Book A Natural History of Human Thinking." American Journal of Psychology 131, no. 3 (2018): 389. http://dx.doi.org/10.5406/amerjpsyc.131.3.0389.

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Ougaard, Morten. "State and Society in International Relations, edited by Michael Banks and Martin Shaw, London: Harvester Wheatsheaf, 1991, 216 s., $ 60.00 hb." Politica 24, no. 2 (January 1, 1992): 229. http://dx.doi.org/10.7146/politica.v24i2.69420.

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35

Krupka, R. M. "Testing transport models and transport data by means of kinetic rejection criteria." Biochemical Journal 260, no. 3 (June 15, 1989): 885–91. http://dx.doi.org/10.1042/bj2600885.

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In the case of a transport system obeying Michaelis-Menten kinetics, completely general relationships are shown to exist between the final ratio of internal and external substrate concentrations, alpha, and the V/Km ratios found in zero-trans-entry, zero-trans-exit and equilibrium-exchange experiments (where V is a maximum substrate flux and Km a substrate half-saturation constant). The proof depends on a new method of derivation proceeding from the form of the experimental data rather than, as has been the practice in kinetic analysis, from a hypothetical reaction scheme. These general relationships, which will be true of all mechanisms giving rise to a particular type of behaviour (here Michaelis-Menten kinetics), provide a test for internal consistency in a set of experimental data. Other relationships, which are specific, can be derived from individual reaction schemes, with the use of traditional procedures in kinetic analysis. The specific relationships include constants for infinite trans entry and exit in addition to constants involved in the general relationships. In conjunction, the general and specific relationships provide a stringent test of mechanism. A set of results that fails to satisfy the general relationships must be rejected; here systematic error or unexpected changes in the transport system in different experiments may have distorted the calculated constants, or the system may not actually obey Michaelis-Menten kinetics. Results in accord with the general relationships, on the other hand, can be applied in specific tests of mechanism. The usefulness of the theorem is illustrated in the cases of the glucose-transport and choline-transport systems of erythrocytes. Experimental results taken from several studies in the literature, which were in accord with hyperbolic substrate kinetics, had previously been shown to disagree with relationships derived for the carrier model, and the model was rejected. The new analysis shows that the data violated the general relationships and therefore cannot decide the issue. More recent results on the glucose-transport system satisfy the general relations and agree with the carrier model.

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Sands, PJ, and PJ Smethurst. "Modelling Nitrogen Uptake in Ingestad Units Using Michaelis-Menten Kinetics." Functional Plant Biology 22, no. 5 (1995): 823. http://dx.doi.org/10.1071/pp9950823.

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The concept of nutrient flux density was developed to grow plants at a controlled and stable relative growth rate whilst maintaining a constant internal concentration of a limiting nutrient. The method requires frequent and exponentially increasing additions of nutrients to replenish uptake. In developing this approach there has been little reference to Michaelis-Menten-like nutrient uptake kinetics for characterising uptake by roots. This paper applies a simple model of nitrogen-limited plant growth using Michaelis-Menten uptake kinetics to data from previously published experiments based on the nutrient flux density approach. It is shown that the model can indeed reproduce key features of experiments: (1) plant relative growth rate equals nitrogen relative addition rate up to a limit; (2) when nitrogen uptake kinetic parameters are within the range reported in the literature, this limiting growth rate agrees with that observed; and (3) solution nitrogen concentrations are consistent with those published. We suggest that the understanding of nutrient uptake and utilisation by plants could be advanced by jointly considering these two approaches.

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Patra, B., A. Maiti, and G. P. Samanta. "Effect of Time-Delay on a Ratio-Dependent Food Chain Model." Nonlinear Analysis: Modelling and Control 14, no. 2 (April 25, 2009): 199–216. http://dx.doi.org/10.15388/na.2009.14.2.14521.

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This paper aims to study the effect of time-delay on a tritrophic food chainmodel with Michaelis-Menten type ratio-dependent functional responses. Boundednessof the time-delayed system is established. A simple criterion for deterministic extinctionis derived. It has been shown that the time-delay may introduce instability in the systemthrough Hopf bifurcation. Computer simulations are carried out to explain the analyticalfindings. It is discussed how these ideas illuminate some of the observed properties ofreal populations in the field, and explores practical implications.

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Bugajska, Anna. "Biopolítica y distopía: la genómica en Next de Michael Crichton." Quaderns de Filosofia 7, no. 2 (February 9, 2021): 59. http://dx.doi.org/10.7203/qfia.7.2.18798.

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Biopolitics and dystopia: genomics in Michael Crichton’s Next Resumen: En este artículo se busca demostrar que, mientras el desarrollo científico es propulsado por el pensamiento tecno-optimista (utópico), el discurso prevalente sobre genómica en la cultura de masas es pesimista (distópico) y tiene potencial para impedir la construcción de respuestas adecuadas a los desafíos biopolíticos por parte de los sistemas políticos y jurídicos. Aquí se sostiene que la utopía genómica es la única propuesta optimista que estimula las investigaciones científicas y que permite pensar en las posibles regulaciones y los cambios necesarios para la conceptualización de la idea de propiedad. Estos problemas son ilustrados con la ayuda del libro de Michael Crichton, Next, que proporciona numerosos ejemplos distópicos. Summary: The article seeks to demonstrate that while scientific development is pro- pelled by technooptimistic thought (utopian), the prevalent discourse about genomics is pessimistic (dystopian), which has the potential to forestall the construction of an adequate answer on the part of political and legal systems. It is shown that genomic utopia is the only optimistic proposition which stimulates scientific research as well as enables thinking about regulations and the necessary changes in the conceptualization of the idea of property. These problems are illustrated with the help of Michael Crichton’s book Next, which provides numerous dystopian examples. Palabras clave: biopolítica, distopía, genómica, sociedad abierta, autopropiedad, Crichton. Keywords: biopolitics, dystopia, genomics, open society, self-ownership, Crichton.

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39

Johnson, Kenneth A. "New standards for collecting and fitting steady state kinetic data." Beilstein Journal of Organic Chemistry 15 (January 2, 2019): 16–29. http://dx.doi.org/10.3762/bjoc.15.2.

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The Michaelis–Menten equation is usually expressed in terms of k cat and K m values: v = k cat[S]/(K m + [S]). However, it is impossible to interpret K m in the absence of additional information, while the ratio of k cat/K m provides a measure of enzyme specificity and is proportional to enzyme efficiency and proficiency. Moreover, k cat/K m provides a lower limit on the second order rate constant for substrate binding. For these reasons it is better to redefine the Michaelis–Menten equation in terms of k cat and k cat/K m values: v = k SP[S]/(1 + k SP[S]/k cat), where the specificity constant, k SP = k cat/K m. In this short review, the rationale for this assertion is explained and it is shown that more accurate measurements of k cat/K m can be derived directly using the modified form of the Michaelis–Menten equation rather than calculated from the ratio of k cat and K m values measured separately. Even greater accuracy is achieved with fitting the raw data directly by numerical integration of the rate equations rather than using analytically derived equations. The importance of fitting to derive k cat and k cat/K m is illustrated by considering the role of conformational changes in enzyme specificity where k cat and k cat/K m can reflect different steps in the pathway. This highlights the pitfalls in attempting to interpret K m, which is best understood as the ratio of k cat divided by k cat/K m.

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Heidi L. Shaw and Matthew H. Scheel. "Response to Rowe's Commentary on Shaw, Scheel, and Gardner's Review of Michael Tomasello's Book A Natural History of Human Thinking." American Journal of Psychology 131, no. 3 (2018): 397. http://dx.doi.org/10.5406/amerjpsyc.131.3.0397.

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41

Falola, Toyin. "Short Changed: Africa and World Trade. Michael Barratt Brown , Pauline TiffenReformism and Revisionism in Africa's Political Economy in the 1990s. Timothy Shaw." Economic Development and Cultural Change 43, no. 4 (July 1995): 908–13. http://dx.doi.org/10.1086/452198.

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Johne, Axel. "Marketing in Evolution:981Edited by Susan Shaw, Neil Hood. Marketing in Evolution: Essays in Honour of Michael J. Baker. UK: Macmillan 1996." European Journal of Marketing 32, no. 1/2 (February 1998): 157. http://dx.doi.org/10.1108/ejm.1998.32.1_2.157.1.

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43

Journal, Baghdad Science. "Kinetic studies of AST isoenzymes I,II,III,IV partially purified from patient,s urine with chroinc renal failure." Baghdad Science Journal 7, no. 1 (March 7, 2010): 437–43. http://dx.doi.org/10.21123/bsj.7.1.437-443.

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In this research, the kinetic studies of four isoenzymes of Asprtate aminotransferase, which partially purified from the urine of chronic renal failure patients were carried out .The four isoenzymes were obeyed Michaelis-Menton's equation and the optimum concentration of their substrate (Aspartic acid) was (166.5x10-3) mole/liter,and their Km values were determined. Four isoenzymesI,II,III,IV have shown an optimum pH at 7.4.The four isoenzymes obeyed Arrhenius equation up to 37º C and their Ea and Q10 constants were determined .

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Levkov, Igor, Tetyana Yegorova, Andriy Kysil, Marc Vedrenne, and Zoia Voitenko. "Reaction of 1-aminoisoindole with 1,4-naphthoquinone and study of the product by spectroscopic methods." French-Ukrainian Journal of Chemistry 6, no. 2 (2018): 27–31. http://dx.doi.org/10.17721/fujcv6i2p27-31.

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In our previous researches we have shown, that 1-aminoisoindole, which exists predominantly in isoindoline tautomeric form, can undergo [4+2]-cycloaddition reactions with maleimides according to the Curtin-Hammet principle. We continued to study this reaction, but with another dienophile – 1,4-naphtoquinone. In this case, the reaction does not stop when the bis-Michael adduct is obtained, but continues with the formation of a more complex compound, the structure of which we have studied by two-dimensional NMR spectroscopic methods.

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45

Stringfellow, William T., and Michael D. Aitken. "Comparative physiology of phenanthrene degradation by two dissimilar pseudomonads isolated from a creosote-contaminated soil." Canadian Journal of Microbiology 40, no. 6 (June 1, 1994): 432–38. http://dx.doi.org/10.1139/m94-071.

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Two species of bacteria, identified as Pseudomonas stutzeri (P-16) and Pseudomonas saccharophila (P-15) by fatty acid methyl ester analysis, were found in a phenanthrene enrichment culture of a creosote-contaminated soil. The organisms are shown to be physiologically dissimilar, and their genetic relatedness is discussed. Phenanthrene degradation by both organisms followed Michaelis–Menten kinetics, allowing for the determination of half-saturation (Ks) and maximum activity coefficients, using nonlinear regression. Both organisms utilized kinetically similar enzymes for phenanthrene uptake and oxidation, as evidenced by similar Ks coefficients of approximately 0.2 mg/L and temperature optima of 40 °C, but levels of expression differed with different media. Each organism degraded phenanthrene via salicylic acid, but patterns of intermediate metabolism were shown to differ. P-15 excreted 1-hydroxy-2-naphthoic acid during growth on phenanthrene and demonstrated Michaelis–Menten kinetics for the oxidation of 1-hydroxy-2-naphthoic acid by resting cells. P-16 excreted only trace amounts of 1-hydroxy-2-naphthoic acid and demonstrated linear kinetics in response to 1-hydroxy-2-naphthoic acid concentration. P-15 was found to form thick biofilms on phenanthrene crystals and was characterized by a hydrophobic cell surface, whereas P-16 grew mostly in suspension and was hydrophilic. Neither organism produced significant amounts of biosurfactants when grown on phenanthrene. The implications of these findings for the design of systems to remediate contaminated soil are discussed.Key words: phenanthrene, 1-hydroxy-2-naphthoic acid, biodegradation, kinetics, polycyclic aromatic hydrocarbons.

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46

Solovyeva, Anna A., Thi Trinh Pham, Olga E. Lebedeva, and Maria N. Ustinova. "HORSERADISH PEROXIDASE CATALYZED DEGRADATION OF BROMOPHENOL BLUE DYE." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 64, no. 1 (December 9, 2020): 93–98. http://dx.doi.org/10.6060/ivkkt.20216401.6267.

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In this study, the oxidative destruction of bromophenol blue dye with hydrogen peroxide was carried out at pH 4.0-4.1 in the presence of a commercial horseradish peroxidase, as well as peroxidase isolated directly from horseradish roots (Armoracia rusticana). To determine peroxidase activity, a model reaction of the oxidation of phenol to quinone was used. With a dye concentration of 32.7 μM, the optimal concentration of hydrogen peroxide was 0.04 mM at peroxidase concentration of 1.15 nM. The optimal temperature of the enzymatic reaction was determined: at 23 °С for 10 min 90% of the dye was exposed to destruction. When the temperature rises to 50 °С, the reaction rate decreases, and the degree of destruction is 56% for the same time interval. It was shown that the initial rate of peroxidase oxidation of bromophenol blue follows Michaelis-Menten equation. The kinetic parameters of the enzymatic reaction were determined by linearizing Michaelis-Menten equation in Lineweaver-Burk coordinates. It was found that for the peroxidase oxidation reaction of bromophenol blue Michaelis constant and maximum rate were 42.7 μM and 57.5 μM·min–1, respectively. In this work, а high percentage of dye degradation was also achieved when using peroxidase isolated from horseradish roots. The experiments were conducted at a temperature of 30оС and pH 4.1. With the increase in the volume of the extract from 0.1 to 0.2 ml, the percentage decolorization increases from 75% to 90%. The results demonstrate the high degradation efficiency of bromophenol blue with the participation of the commercial horseradish peroxidase and peroxidase isolated from horseradish roots. Enzymatic oxidative degradation can be considered as an alternative to biodegradation.

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47

Solovyeva, Anna A., Thi Trinh Pham, Olga E. Lebedeva, and Maria N. Ustinova. "HORSERADISH PEROXIDASE CATALYZED DEGRADATION OF BROMOPHENOL BLUE DYE." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 64, no. 1 (December 9, 2020): 93–98. http://dx.doi.org/10.6060/ivkkt.20216401.6267.

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In this study, the oxidative destruction of bromophenol blue dye with hydrogen peroxide was carried out at pH 4.0-4.1 in the presence of a commercial horseradish peroxidase, as well as peroxidase isolated directly from horseradish roots (Armoracia rusticana). To determine peroxidase activity, a model reaction of the oxidation of phenol to quinone was used. With a dye concentration of 32.7 μM, the optimal concentration of hydrogen peroxide was 0.04 mM at peroxidase concentration of 1.15 nM. The optimal temperature of the enzymatic reaction was determined: at 23 °С for 10 min 90% of the dye was exposed to destruction. When the temperature rises to 50 °С, the reaction rate decreases, and the degree of destruction is 56% for the same time interval. It was shown that the initial rate of peroxidase oxidation of bromophenol blue follows Michaelis-Menten equation. The kinetic parameters of the enzymatic reaction were determined by linearizing Michaelis-Menten equation in Lineweaver-Burk coordinates. It was found that for the peroxidase oxidation reaction of bromophenol blue Michaelis constant and maximum rate were 42.7 μM and 57.5 μM·min–1, respectively. In this work, а high percentage of dye degradation was also achieved when using peroxidase isolated from horseradish roots. The experiments were conducted at a temperature of 30оС and pH 4.1. With the increase in the volume of the extract from 0.1 to 0.2 ml, the percentage decolorization increases from 75% to 90%. The results demonstrate the high degradation efficiency of bromophenol blue with the participation of the commercial horseradish peroxidase and peroxidase isolated from horseradish roots. Enzymatic oxidative degradation can be considered as an alternative to biodegradation.

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Ashok, Dongamanti, Bommidi Lakshmi, Sidda Ravi, and Arram Ganesh. "Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity." Journal of the Serbian Chemical Society 80, no. 3 (2015): 305–13. http://dx.doi.org/10.2298/jsc140021101a.

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A series of pyrazolines 4a-g have been synthesized by Michael addition of chalcones 3a-g with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation. Structures of the newly synthesized chalcones 3a-g and pyrazolines 4a-g have been established on the basis of IR, 1H & 13C NMR and mass spectral data. All the synthesized compounds were screened for their antimicrobial activity. Some of the compounds shown very good activity compared to standard drugs against all pathogenic bacteria and fungi.

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Lemke, Thomas. "Biopolitik im Empire." PROKLA. Zeitschrift für kritische Sozialwissenschaft 32, no. 129 (December 1, 2002): 619–29. http://dx.doi.org/10.32387/prokla.v32i129.690.

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A vivid and controversial debate followed the publication of Empire by Michael Hardt and Antonio Negri. This contribution discusses the concept of biopower as it is presented in the book. While the authors modify and expand the use of the notion that was developed by Michel Foucault, they produce several systematic problems and theoretical ambivalences. As it will be shown, Hardt and Negri claim to ground their analysis in a "field of immanence", but partly fail to do so, weakening their own political and critical perspectlve.

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Bentzen, E., and W. D. Taylor. "Estimating Michaelis–Menten Parameters and Lake Water Phosphate by the Rigler Bioassay: Importance of Fitting Technique, Plankton Size, and Substrate Range." Canadian Journal of Fisheries and Aquatic Sciences 48, no. 1 (January 1, 1991): 73–83. http://dx.doi.org/10.1139/f91-011.

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Evaluation of the Michaelis–Menten parameters Vm and Kt for phosphate (PO43−) uptake by plankton is difficult because of differences in nutrient uptake by the various species. Studies using simulated data have shown that fitting the equation by nonlinear regression is preferable to linearized transformations for estimating Vm and Kt; however, the actual velocity of PO43− uptake by lake plankton cannot be measured because the ambient concentration of PO43− (Pn) is unknown. For natural plankton, a better fit is demonstrated using another nonlinear model which fits the uptake rate constant for 32PO43− directly to the PO43− added in the kinetic experiment, and the mixed community effect is minimized by isolating different plankton size fractions. Another consequence of not knowing Pn is that the estimate of Kt cannot be distinguished from Pn′ and the sum of the two is always obtained. The low substrate region of the Michaelis–Menten curve is used in the Rigler bioassay as a means of estimating the upper bound to Pn. Error in the uptake rate constants influences the estimate of the Rigler Pn′ and the Rigler maximum Pn is equal to the estimated (Kt + Pn) of the 0.2–1 μm size fraction.

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