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Journal articles on the topic 'Microalgal therapeutics'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Cutolo, Edoardo Andrea, Roberto Caferri, Rosanna Campitiello, and Maurizio Cutolo. "The Clinical Promise of Microalgae in Rheumatoid Arthritis: From Natural Compounds to Recombinant Therapeutics." Marine Drugs 21, no. 12 (2023): 630. http://dx.doi.org/10.3390/md21120630.

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Rheumatoid arthritis (RA) is an invalidating chronic autoimmune disorder characterized by joint inflammation and progressive bone damage. Dietary intervention is an important component in the treatment of RA to mitigate oxidative stress, a major pathogenic driver of the disease. Alongside traditional sources of antioxidants, microalgae—a diverse group of photosynthetic prokaryotes and eukaryotes—are emerging as anti-inflammatory and immunomodulatory food supplements. Several species accumulate therapeutic metabolites—mainly lipids and pigments—which interfere in the pro-inflammatory pathways i

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Shoham, Shani, Noam Pintel, and Dorit Avni. "Oxidative Stress, Gut Bacteria, and Microalgae: A Holistic Approach to Manage Inflammatory Bowel Diseases." Antioxidants 14, no. 6 (2025): 697. https://doi.org/10.3390/antiox14060697.

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Oxidative stress is a recognized contributor to the pathophysiology of inflammatory bowel disease (IBD), exacerbating chronic inflammation and tissue damage. While traditional IBD therapies primarily focus on immune modulation, alternative approaches that address oxidative stress and promote gut microbial health present new opportunities for symptom relief and disease management. Microalgae, known for their potent antioxidant, anti-inflammatory, and prebiotic properties, show promise in alleviating oxidative damage and supporting beneficial gut bacteria. This review explores the multifaceted r

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Dutton, Gail. "Microalgal Vesicles Deliver Therapeutics to Protected Tissues." Genetic Engineering & Biotechnology News 42, no. 12 (2022): 14–15. http://dx.doi.org/10.1089/gen.42.12.05.

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Kiran, Boda Ravi, and S. Venkata Mohan. "Microalgal Cell Biofactory—Therapeutic, Nutraceutical and Functional Food Applications." Plants 10, no. 5 (2021): 836. http://dx.doi.org/10.3390/plants10050836.

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Microalgae are multifaceted photosynthetic microorganisms with emerging business potential. They are present ubiquitously in terrestrial and aquatic environments with rich species diversity and are capable of producing significant biomass. Traditionally, microalgal biomass is being used as food and feed in many countries around the globe. The production of microalgal-based bioactive compounds at an industrial scale through biotechnological interventions is gaining interest more recently. The present review provides a detailed overview of the key algal metabolites, which plays a crucial role in

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Chae, Hae-Jung, Jong Bae Seo, Sung-Hak Kim, Ei Joung Youn, Sanghee Kim, and Sung-Suk Suh. "Antarctic Freshwater Microalga, Micractinium simplicissimum, Suppresses Inflammation." Journal of Nanoscience and Nanotechnology 21, no. 7 (2021): 4098–103. http://dx.doi.org/10.1166/jnn.2021.19158.

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Inflammation mediated by the innate immune system is the organism’s protective mechanism against infectious environmental risk factors. Uncontrolled acute inflammation can become chronic, contributing to various chronic inflammatory diseases such as arthritis, asthma, autoimmune diseases, and atherosclerosis. Although microalgae are increasingly receiving attention as a source of bioactive molecules with therapeutic potential for various human diseases, the underlying mechanisms are not yet well understood. In the present study, we investigated the molecular mechanisms underlying the anti-infl

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Sirohi, Priyanka, Hariom Verma, Sandeep Kumar Singh, et al. "Microalgal Carotenoids: Therapeutic Application and Latest Approaches to Enhance the Production." Current Issues in Molecular Biology 44, no. 12 (2022): 6257–79. http://dx.doi.org/10.3390/cimb44120427.

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Microalgae are microscopic photosynthetic organisms frequently found in fresh and marine water ecosystems. Various microalgal species have been considered a reservoir of diverse health-value products, including vitamins, proteins, lipids, and polysaccharides, and are broadly utilized as food and for the treatment of human ailments such as cancer, cardiovascular diseases, allergies, and immunodeficiency. Microalgae-derived carotenoids are the type of accessory pigment that possess light-absorbing potential and play a significant role in metabolic functions. To date, nearly a thousand carotenoid

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Barolo, Lorenzo, Raffaela M. Abbriano, Audrey S. Commault, et al. "Perspectives for Glyco-Engineering of Recombinant Biopharmaceuticals from Microalgae." Cells 9, no. 3 (2020): 633. http://dx.doi.org/10.3390/cells9030633.

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Microalgae exhibit great potential for recombinant therapeutic protein production, due to lower production costs, immunity to human pathogens, and advanced genetic toolkits. However, a fundamental aspect to consider for recombinant biopharmaceutical production is the presence of correct post-translational modifications. Multiple recent studies focusing on glycosylation in microalgae have revealed unique species-specific patterns absent in humans. Glycosylation is particularly important for protein function and is directly responsible for recombinant biopharmaceutical immunogenicity. Therefore,

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Çelekli, Abuzer, Buket Özbal, and Hüseyin Bozkurt. "Challenges in Functional Food Products with the Incorporation of Some Microalgae." Foods 13, no. 5 (2024): 725. http://dx.doi.org/10.3390/foods13050725.

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Much attention has been given to the use of microalgae to produce functional foods that have valuable bioactive chemicals, including essential amino acids, polyunsaturated fatty acids, vitamins, carotenoids, fiber, and minerals. Microalgal biomasses are increasingly being used to improve the nutritional values of foods because of their unique nutrient compositions that are beneficial to human health. Their protein content and amino acid composition are the most important components. The microalgal biomass used in the therapeutic supplement industry is dominated by bio-compounds like astaxanthi

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Sonu, Kumar1 Arvind Kumar1 Amisha Kumari1 Gagan Gaykwad1 Sahil Singh1 Aman Sahu1 Sajid Ansari1 Faiz Alam1 Md. Khatibul Ansari1 Arti Kumari1 Aditya Raj Gupta1 Nishikant Kumar1 Ritesh Kumar Dubey1 Sudhanshu Shekhar1 Arnab Roy2* Mahesh Kumar Yadav3 Ankita Singh4 Dr. K. Rajeswar Dutt5. "Unveiling the Green Gold: A Comprehensive Review of Arthrospira Platensis's Botanical, Pharmacological and Biotechnological Aspects with Emphasis on Anti-Oxidant Activity." International Journal of Scientific Research and Technology 2, no. 5 (2025): 338–54. https://doi.org/10.5281/zenodo.15421425.

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The microscopic blue-green microalgae <em>Arthrospira platensis</em> represents a fascinating intersection of nutritional science, ecological sustainability, and biomedical potential. This cyanobacterium transcends traditional nutritional paradigms, offering a complex biochemical profile that has captivated researchers across multiple scientific disciplines. Its remarkable composition encompasses an extensive array of bioactive compounds, including high-quality proteins, essential amino acids, vitamins, minerals, and extraordinary antioxidant molecules that demonstrate significant protective c

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López-Hernández, Jenny-Fabiola, Tan Kean-Meng, Gloria-Gertrudys Asencio-Alcudia, Mohd Asyraf-Kassim, Carlos-Alfonso Alvarez-González, and Facundo-Joaquín Márquez-Rocha. "Sustainable Microalgae and Cyanobacteria Biotechnology." Applied Sciences 12, no. 14 (2022): 6887. http://dx.doi.org/10.3390/app12146887.

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Marine organisms are a valuable source of new compounds, many of which have remarkable biotechnological properties, such as microalgae and cyanobacteria, which have attracted special attention to develop new industrial production routes. These organisms are a source of many biologically active molecules in nature, including antioxidants, immunostimulants, antivirals, antibiotics, hemagglutinates, polyunsaturated fatty acids, peptides, proteins, biofuels, and pigments. The use of several technologies to improve biomass production, in the first step, industrial processes schemes have been addres

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Sousa, Júlia Santos Pinto de, Suzana Telles da Cunha Lima, Vitória Pereira de Oliveira, Esther Carvalho Nascimento, and Carlos Eduardo Sampaio Guedes. "Visceral leishmaniasis: Therapeutic challenges and the potential of microalgae as a source of antileishmanial compounds." Research, Society and Development 13, no. 12 (2024): e145131247645. https://doi.org/10.33448/rsd-v13i12.47645.

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Leishmaniases are diseases caused by protozoa of the Leishmania genus, transmitted by sandflies, manifesting as visceral, cutaneous, or mucocutaneous forms. Classified as a neglected tropical disease, it disproportionately affects vulnerable populations, especially in low-income regions. This narrative literature review aimed to assess current knowledge on the therapeutic potential of microalgal extracts and compounds for the treatment of visceral leishmaniasis. The research was conducted using the PubMed, SciELO, and Google Scholar databases, employing the keywords Leishmania infantum, Viscer

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Chekunova, Elena M., and Pavel A. Virolainen. "Microalgae as production systems of bioactive compounds. Bioengineering approaches." Ecological genetics 21, no. 3S (2023): 38–39. http://dx.doi.org/10.17816/ecogen568627.

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Microalgae contain a wide range of useful substances: antioxidants, lipids, proteins, carbohydrates and secondary metabolites which could be used in nutraceuticals and dietary supplements. Green microalgaeChlorellacontaining highest amount of chlorophylls of any known plant, 60% protein, 18 amino acids, 20 vitamins and minerals [1]. Microalgae are exceptionally rich source of pharmacologically active metabolites with antineoplastic, antitumor, antibacterial, antifungal and antiviral properties and, also capable of wastewater treatment, and biomass production. The genetic information can

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Bhatia, Latika, and Dilip Kumar Sahu. "Third Generation Biorefineries: An Approach towards a Sustainable Future." South Asian Journal of Research in Microbiology 19, no. 7 (2025): 26–39. https://doi.org/10.9734/sajrm/2025/v19i7449.

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Microalgae are the broad range of photosynthetic autotrophs that are found both in fresh and marine water bodies worldwide. Microalgae are the known for producing value added products via the sequestration of carbon dioxide. This production is supported by other salient features like higher light conversion efficiency, higher substrate conversion efficiency, higher biomass productivities and shorter generation time. Microalgae biomass can be contemplated as a microbial cell factory that potentially biosynthesize wide range of value-added biomolecules like biopigments, therapeutic compounds, bi

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Cichoński, Jan, and Grzegorz Chrzanowski. "Microalgae as a Source of Valuable Phenolic Compounds and Carotenoids." Molecules 27, no. 24 (2022): 8852. http://dx.doi.org/10.3390/molecules27248852.

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Microalgae are photosynthetic, eukaryotic organisms that are widely used in the industry as cell factories to produce valuable substances, such as fatty acids (polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), sterols (sitosterol), recombinant therapeutic proteins, carbohydrates, vitamins, phenolic compounds (gallic acid, quercetin), and pigments (β-carotene, astaxanthin, lutein). Phenolic compounds and carotenoids, including those extracted from microalgae, possess beneficial bioactivities such as antioxidant capacity, antimicrobial and immunomod

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Cao, B., O. B. Chivkunova, A. E. Solovchenko, E. S. Lobakova, and A. V. Oleskin. "Impact of Neurotransmitters on the Fatty Acid Composition and the Pigments of the Green Microalga Scenedesmus quadricauda." Applied Biochemistry and Microbiology 60, no. 5 (2024): 833–43. http://dx.doi.org/10.1134/s0003683824604554.

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Abstract Apart from their functions in the nervous system of animals, neurotransmitters operate as regulatory agents and signals in diverse kingdoms of life. Some neurotransmitters have recently been revealed to exert specific effects on microalgae, predominantly functioning as algal growth stimulators. This article presents new data on the effects of such neurotransmitters as serotonin, norepinephrine, dopamine, histamine, and acetylcholine on the fatty acid and pigment composition of the green microalga Scenedesmus quadricauda (Turp.) Breb. K-1149. It was established that acetylcholine and,

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Sabooryar, Junaiadullah. "Evaluation of Cytotoxic Potentials of Microalgae on Hela, Hepg-2, HT-29 and EACC Cells to Develop Anticancer Agents." Cross Current International Journal of Medical and Biosciences 2, no. 2 (2020): 11–16. http://dx.doi.org/10.36344/ccijmb.2020.v02i02.001.

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Finding more effective methods to treat cancer remains a challenge, and development of new therapeutic agents for cancer treatment is essential for continued progress against the disease. This study was conducted to evaluate the in vitro antiproliferative activity of methanolic extracts of Chlorella vulgaris and Nostoc muscorum against Human cervical Cancer cells (HeLa), liver hepatocellular cells (HepG-2), Human colorectal adenocarcinoma cells (HT-29) and Ehrlich Ascites Carcinoma Cells (EACC) in order to determine the bioacitivities of microalgae. Morphological changes of cancer cells treate

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Dimopoulou, Maria, Alexandros Kolonas, Dimitris Stagos, and Olga Gortzi. "A Review of the Sustainability, Chemical Composition, Bioactive Compounds, Antioxidant and Antidiabetic Activity, Neuroprotective Properties, and Health Benefits of Microalgae." Biomass 5, no. 1 (2025): 11. https://doi.org/10.3390/biomass5010011.

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Microalgae have emerged as a valuable source of essential nutrients and bioactive compounds, such as proteins, polyphenols, and polysaccharides, which are critical for overall health. Recent research has demonstrated the therapeutic potential of microalgae in addressing a variety of health conditions, including inflammation, oxidative stress, Type 2 diabetes mellitus (T2DM), and neurological disorders. The aim of this paper is to investigate the chemical composition, nutritional value, and biological properties of microalgae. Relevant information was gathered through a comprehensive search of

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S., S. Kadam A. V. Sahasrabudhe* S. S. Barve. "Antioxidant and Antimicrobial activity of Crude Sterol from Chlorella." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 2094–101. https://doi.org/10.5281/zenodo.15234170.

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The study investigates the antioxidant and antimicrobial activities of crude sterol extracted from <em>Chlorella</em>, a green microalga known for its potential therapeutic properties. Sterols are one of the important compounds obtained from Plant oils. Microalgae can be an alternative source of the sterols in future. Sterols have proven records of hypocholesterolemic properties. <em>Chlorella</em> is a well-known microalga for its multiple health benefits and properties. These study findings suggest that <em>Chlorella</em>-derived sterols possess better antimicrobial activities than antioxida

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Wang, Xiaocheng, Chaoyu Yang, Yunru Yu, and Yuanjin Zhao. "In Situ 3D Bioprinting Living Photosynthetic Scaffolds for Autotrophic Wound Healing." Research 2022 (March 20, 2022): 1–11. http://dx.doi.org/10.34133/2022/9794745.

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Three-dimensional (3D) bioprinting has been extensively explored for tissue repair and regeneration, while the insufficient nutrient and oxygen availability in the printed constructs, as well as the lack of adaptive dimensions and shapes, compromises the overall therapeutic efficacy and limits their further application. Herein, inspired by the natural symbiotic relationship between salamanders and algae, we present novel living photosynthetic scaffolds by using an in situ microfluidic-assisted 3D bioprinting strategy for adapting irregular-shaped wounds and promoting their healing. As the oxyg

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Zeynep Aydin, Sude Karaoğlan, Zeynep Aydin, Sude Karaoğlan, and Gozde Yeshiltash Gozde Yeshiltash. "INVESTIGATION OF ANTI-CANCER PROPERTIES OF COMPONENTS EXTRACTED FROM POLAR MICROALGAE." PIRETC-Proceeding of The International Research Education & Training Centre 30, no. 01 (2024): 74–83. http://dx.doi.org/10.36962/piretc30012024-74.

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Cancer is irregular cell division that can be inherited or occur under environmental factors. Due to mutations in DNA, damage occurs in the cell division mechanism and cells divide uncontrollably [1]. Natural compounds are widely preferred in the treatment of cancer, which is the second leading cause of death. Microalgae have a great role in cancer treatment because they have rich bioactive components and high efficiency [2,3]. Microalgal biomass has many uses in a wide variety of fields, thanks to its potential for rich bioactive compounds and its ability to be used as a sustainable bio- prod

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Chwil, Mirosława, Rok Mihelič, Renata Matraszek-Gawron, Paulina Terlecka, Michał M. Skoczylas, and Karol Terlecki. "Comprehensive Review of the Latest Investigations of the Health-Enhancing Effects of Selected Properties of Arthrospira and Spirulina Microalgae on Skin." Pharmaceuticals 17, no. 10 (2024): 1321. http://dx.doi.org/10.3390/ph17101321.

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Arthospira platensis and Spirulina platensis microalgae are a rich source of pro-health metabolites (% d.m.): proteins (50.0–71.3/46.0–63.0), carbohydrates (16.0–20.0/12.0–17.0), fats (0.9–14.2/6.4–14.3), polyphenolic compounds and phenols (7.3–33.2/7.8–44.5 and 4.2/0.3 mg GAE/g), and flavonoids (1.9/0.2 QUE/g) used in pharmaceutical and cosmetic formulations. This review summarises the research on the chemical profile, therapeutic effects in dermatological problems, application of Arthrospira and Spirulina microalgae, and contraindications to their use. The pro-health properties of these micr

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Abreu, Ana P., Rodrigo Martins, and João Nunes. "Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp." Bioengineering 10, no. 8 (2023): 955. http://dx.doi.org/10.3390/bioengineering10080955.

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Chlorella sp. and Spirulina (Arthrospira) sp. account for over 90% of the global microalgal biomass production and represent one of the most promising aquiculture bioeconomy systems. These microorganisms have been widely recognized for their nutritional and therapeutic properties; therefore, a significant growth of their market is expected, especially in the nutraceutical, food, and beverage segments. However, recent advancements in biotechnology and environmental science have led to the emergence of new applications for these microorganisms. This paper aims to explore these innovative applica

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Dehghani, Jaber, Ali Movafeghi, Elodie Mathieu-Rivet, et al. "Microalgae as an Efficient Vehicle for the Production and Targeted Delivery of Therapeutic Glycoproteins against SARS-CoV-2 Variants." Marine Drugs 20, no. 11 (2022): 657. http://dx.doi.org/10.3390/md20110657.

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Severe acute respiratory syndrome–Coronavirus 2 (SARS-CoV-2) can infect various human organs, including the respiratory, circulatory, nervous, and gastrointestinal ones. The virus is internalized into human cells by binding to the human angiotensin-converting enzyme 2 (ACE2) receptor through its spike protein (S-glycoprotein). As S-glycoprotein is required for the attachment and entry into the human target cells, it is the primary mediator of SARS-CoV-2 infectivity. Currently, this glycoprotein has received considerable attention as a key component for the development of antiviral vaccines or

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Tsvetanova, Flora, and Dragomir Yankov. "Bioactive Compounds from Red Microalgae with Therapeutic and Nutritional Value." Microorganisms 10, no. 11 (2022): 2290. http://dx.doi.org/10.3390/microorganisms10112290.

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Red microalgae represent a natural reservoir of beneficial substances with applications in different industrial sectors. They are rich in natural biomolecules known for their antihypertensive, antioxidant, antimicrobial, antiviral, anti-inflammatory, antitumor, and anticoagulant activities. Many red microalgae are a source of vitamins, minerals, photochemicals, polyunsaturated fatty acids, and a wide spectrum of polysaccharides. The content of their valuable compounds and their activities have turned red microalgae into cellular factories of special interest in food, nutraceutical, and pharmac

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Derya Andeden, Muazzez, Pınar Altın Çelik, Enver Ersoy Andeden, Şahlan Öztürk, and Hamiyet Altuntaş. "Antioxidant capacity, total phenolic content, and in vitro cytotoxic and oxidative effects of the methanol extract of Dunaliella sp. against breast cancer cells." International Journal of Secondary Metabolite 12, no. 3 (2025): 498–511. https://doi.org/10.21448/ijsm.1514559.

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Microalgae are rich sources of essential biomolecules, including proteins, pigments, and a diverse array of secondary metabolites such as carotenoids, polyphenols, sterols, polyunsaturated fatty acids, and polysaccharides, which they secrete at various growth stages. Owing to this property, microalgae are gaining significant research interest as natural product producers with cell-protective potential and minimal or no side effects compared to synthetic drugs. This study explores the potential of the methanol extract of Dunaliella sp. (mD) as an in vitro therapeutic agent for breast cancer. Th

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Toumi, Amira, Yulia A. Smyatskaya, and Natalia A. Politaeva. "Use of Chlorella sorokiniana biomass as an oral sorbent." Butlerov Communications 61, no. 1 (2020): 126–32. http://dx.doi.org/10.37952/roi-jbc-01/20-61-1-126.

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This article presents an assessment of the biosorption capacity of Chlorella sorokiniana microalgae in relation to heavy metal ions (Zn2+, Cd2+, Pb2+, Cu2+) at various pH values. With the development of industry, several environmental threats have emerged, including heavy metal pollution. This form of pollution has negative effects in the short and long term on the health of animals and humans. To prevent the accumulation of harmful substances in the human body, it is advised to use oral sorbents in prophylactic and therapeutic purposes. Oral sorbents have the ability to adsorb and neutralize

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De Sousa Filho, Walter Paixão, Mariana Zancan Tonel, Vinícius Rodrigues Oviedo, Liana Da Silva Fernandes, Diego De Souza, and Michele Rorato Sagrillo. "Biogenic Synthesis and antibiofilm efficacy of iron nanoparticles via computer simulation." International Journal for Innovation Education and Research 10, no. 8 (2022): 1–10. http://dx.doi.org/10.31686/ijier.vol10.iss8.3686.

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The search for new drugs can be accelerated by in silico methods, i.e., fully computational methods known for their speed and low cost, allowing the analysis of a large amount of data, e.g., thousands of possible antimicrobials, in a few weeks. Molecular docking and first-principles calculations are great allies in this quest. They enable the assessment of protein-ligand interactions and can predict interactions between NPs and macromolecules to provide more information about the interactions and dynamics of NPs in biological systems. In this context, this work aims to use in silico methods to

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Tamel Selvan, Kartthigeen, Jo Aan Goon, Suzana Makpol, and Jen Kit Tan. "Therapeutic Potentials of Microalgae and Their Bioactive Compounds on Diabetes Mellitus." Marine Drugs 21, no. 9 (2023): 462. http://dx.doi.org/10.3390/md21090462.

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Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or both. Oxidative stress and chronic low-grade inflammation play crucial roles in the pathophysiology of diabetes mellitus. There has been a growing interest in applying natural products to improve metabolic derangements without the side effects of anti-diabetic drugs. Microalgae biomass or extract and their bioactive compounds have been applied as nutraceuticals or additives in food products and health supplements. Several studies have demonstrated the therapeutic e

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Ávila-Román, Javier, Sara García-Gil, Azahara Rodríguez-Luna, Virginia Motilva, and Elena Talero. "Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids." Marine Drugs 19, no. 10 (2021): 531. http://dx.doi.org/10.3390/md19100531.

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Acute inflammation is a key component of the immune system’s response to pathogens, toxic agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing pathogenic factors and restoring tissue homeostasis. However, uncontrolled acute inflammatory response may lead to chronic inflammation, which is involved in the development of many diseases, including cancer. Nowadays, the need to find new potential therapeutic compounds has raised the worldwide scientific interest to study the marine environment. Specifically, microalgae are considered rich sources of bioactive m

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Abdul, Kader Mohiuddin. "Therapeutic Values of Microalgae: A Comprehensive Review." Journal of Pharmaceutics and Drug Research 3, no. 2 (2020): 280–314. https://doi.org/10.5281/zenodo.3596645.

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The global economic effect of the five driving chronic diseases — malignancy, diabetes, psychological instability, CVD and respiratory disease — could reach $47 trillion throughout the following 20 years, as indicated by an examination by the World Economic Forum (WEF). As per the WHO, 80% of the total people principally those of developing countries depend on plant-inferred medicines for social insurance. The indicated efficacies of seaweed inferred phytochemicals are demonstrating incredible potential in obesity, T2DM, metabolic syndrome, CVD, IBD, sexual dysfunction and a few ca

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Ahirwar, Ankesh, Khushboo Kesharwani, Rahul Deka, et al. "Microalgal drugs: A promising therapeutic reserve for the future." Journal of Biotechnology 349 (April 2022): 32–46. http://dx.doi.org/10.1016/j.jbiotec.2022.03.012.

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Raj, Subhisha, Anusree M. Kuniyil, Arathi Sreenikethanam, Poornachandar Gugulothu, Rajesh Banu Jeyakumar, and Amit K. Bajhaiya. "Microalgae as a Source of Mycosporine-like Amino Acids (MAAs); Advances and Future Prospects." International Journal of Environmental Research and Public Health 18, no. 23 (2021): 12402. http://dx.doi.org/10.3390/ijerph182312402.

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Mycosporine-like amino acids (MAAs), are secondary metabolites, first reported in 1960 and found to be associated with the light-stimulated sporulation in terrestrial fungi. MAAs are nitrogenous, low molecular weight, water soluble compounds, which are highly stable with cyclohexenone or cycloheximine rings to store the free radicals. Microalgae are considered as a good source of different kinds of MAAs, which in turn, has its own applications in various industries due to its UV absorbing, anti-oxidant and therapeutic properties. Microalgae can be easily cultivated and requires a very short ge

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Bertolin, Telma Elita, Dayane Pilatti, Ana Cristina Vendrametto Varrone Giacomini, Caren Serra Bavaresco, Luciane Maria Colla, and Jorge Alberto Vieira Costa. "Effect of microalga Spirulina platensis (Arthrospira platensis) on hippocampus lipoperoxidation and lipid profile in rats with induced hypercholesterolemia." Brazilian Archives of Biology and Technology 52, no. 5 (2009): 1253–59. http://dx.doi.org/10.1590/s1516-89132009000500024.

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Studies have been conducted on microalga Spirulina platensis (Arthrospira platensis) due to its therapeutic potential in several areas, including the capacity for preventing and decreasing the damages caused by hyperlipidemia and the antioxidant activity. The aim of the study was to evaluate the effect of microalga Spirulina platensis on hippocampus lipoperoxidation and lipid profile in rats with induced hypercholesterolemia during 60 days. The measurement of hippocampus lipoperoxidation did not demonstrate significant difference (p>0.05) when Spirulina platensis was added to hypercholester

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Wagle, Sajeev, Julie Anne Lee, and H. P. Vasantha Rupasinghe. "Synergistic Cytotoxicity of Extracts of Chaga Mushroom and Microalgae against Mammalian Cancer Cells In Vitro." Oxidative Medicine and Cellular Longevity 2024 (January 17, 2024): 1–13. http://dx.doi.org/10.1155/2024/7944378.

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Chaga mushroom (Inonotus obliquus) contains bioactive metabolites and has been used to treat various ailments, including cancer. Similarly, marine microalgae are considered a sustainable food supplement with anticancer and antioxidant properties. This study investigated the cytotoxicity of different extracts prepared from I. obliquus and microalgae using cultured human and canine cancer cell lines (MCF-7, HepG2, HOS, D-17, and DH-82). MTS cell viability assay was used to study the cytotoxicity of I. obliquus and microalgae extracts, and a synergy matrix effect was used to study the combined ef

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Widyaningrum, D., R. A. Oktafika, and D. Cecilia. "Microalgae pigments as a promising immunomodulating food ingredient: In silico study." IOP Conference Series: Earth and Environmental Science 998, no. 1 (2022): 012056. http://dx.doi.org/10.1088/1755-1315/998/1/012056.

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Abstract Microalgae pigments attract the commercial market as functional food ingredients because of their potential as an antioxidant and anti-inflammatory agents. Through in vitro and in vivo studies, microalgae pigments showed a potential therapeutic effect to reduce the expression of pro-inflammatory cytokines by inhibiting inflammation signaling. Our study explored the potency of microalgae pigments as an immunomodulator by modeling the direct interaction between pigments and pro-inflammatory proteins by molecular docking. The docking study was carried out using AutoDock Vina. At the same

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Banerjee, Anirban, and Valerie Ward. "Production of recombinant and therapeutic proteins in microalgae." Current Opinion in Biotechnology 78 (December 2022): 102784. http://dx.doi.org/10.1016/j.copbio.2022.102784.

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Menaa, Farid, Udari Wijesinghe, Gobika Thiripuranathar, et al. "Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs?" Marine Drugs 19, no. 9 (2021): 484. http://dx.doi.org/10.3390/md19090484.

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Marine algae are rich in bioactive nutraceuticals (e.g., carbohydrates, proteins, minerals, fatty acids, antioxidants, and pigments). Biotic (e.g., plants, microorganisms) and abiotic factors (e.g., temperature, pH, salinity, light intensity) contribute to the production of primary and secondary metabolites by algae. Easy, profitable, and sustainable recovery methods include novel solid-liquid and liquid-liquid extraction techniques (e.g., supercritical, high pressure, microwave, ultrasound, enzymatic). The spectacular findings of algal-mediated synthesis of nanotheranostics has attracted furt

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Ma, Mu. "The Potential of Microalgae in the Era of Antibiotic Resistance." Theoretical and Natural Science 81, no. 1 (2025): 73–80. https://doi.org/10.54254/2753-8818/2025.21326.

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A major global health issue is antimicrobial resistance. Antibiotic resistance is caused by bacteria gradually developing resistance to antibiotics. This resistance allows bacteria to survive conventional therapeutic doses of antibiotics, leading to persistent infections and making treatment more difficult. The emergence of antibiotic resistance in microalgae is a complicated biological process that is connected to a number of variables, such as bacterial-microalgae interactions, environmental pollution, and antibiotic use. This study reviews the antibacterial mechanisms of microalgae and thei

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Sidorowicz, Agnieszka, Giacomo Fais, Mattia Casula, et al. "Nanoparticles from Microalgae and Their Biomedical Applications." Marine Drugs 21, no. 6 (2023): 352. http://dx.doi.org/10.3390/md21060352.

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Over the years, microalgae have been a source of useful compounds mainly used as food and dietary supplements. Recently, microalgae have been used as a source of metabolites that can participate in the synthesis of several nanoparticles through inexpensive and environmentally friendly routes alternative to chemical synthesis. Notably, the occurrence of global health threats focused attention on the microalgae application in the medicinal field. In this review, we report the influence of secondary metabolites from marine and freshwater microalgae and cyanobacteria on the synthesis of nanopartic

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Mourelle, M. Lourdes, Carmen P. Gómez, and José L. Legido. "Microalgal Peloids for Cosmetic and Wellness Uses." Marine Drugs 19, no. 12 (2021): 666. http://dx.doi.org/10.3390/md19120666.

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Peloids have been used for therapeutic purposes since time immemorial, mainly in the treatment of locomotor system pathologies and dermatology. Their effects are attributed to their components, i.e., to the properties and action of mineral waters, clays, and their biological fraction, which may be made up of microalgae, cyanobacteria, and other organisms present in water and clays. There are many studies on the therapeutic use of peloids made with microalgae/cyanobacteria, but very little research has been done on dermocosmetic applications. Such research demonstrates their potential as soothi

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Patel, JS, MR Patel, Reddy B. A, and BL Raghunandan. "Spirulina: nutritional and therapeutic review." AgriSustain-An International Journal 01, no. 01 (2023): 11–15. https://doi.org/10.5281/zenodo.8385372.

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The current environmental conditions deteriorations, mental and physical stress, changes in the diet have been serious risk factors for the humans, increased the death rate and civilization diseases. These are the obvious reasons why new progressive trends are being extensively developed in modern medicine, pharmacology and biotechnology and more effective harmless medicaments are being sought for to treat and prevent various diseases. One of the trends in biotechnology is associated with Blue green microalgae Spirulina platensis which have been widely employed as food and feed additives in ag

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Castellano, Immacolata, and Florian P. Seebeck. "On ovothiol biosynthesis and biological roles: from life in the ocean to therapeutic potential." Natural Product Reports 35, no. 12 (2018): 1241–50. http://dx.doi.org/10.1039/c8np00045j.

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Balasubramaniam, Vimala, Rathi Devi-Nair Gunasegavan, Suraiami Mustar, June Chelyn Lee, and Mohd Fairulnizal Mohd Noh. "Isolation of Industrial Important Bioactive Compounds from Microalgae." Molecules 26, no. 4 (2021): 943. http://dx.doi.org/10.3390/molecules26040943.

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Microalgae are known as a rich source of bioactive compounds which exhibit different biological activities. Increased demand for sustainable biomass for production of important bioactive components with various potential especially therapeutic applications has resulted in noticeable interest in algae. Utilisation of microalgae in multiple scopes has been growing in various industries ranging from harnessing renewable energy to exploitation of high-value products. The focuses of this review are on production and the use of value-added components obtained from microalgae with current and potenti

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Pankaj, Sonawane, Bhosale Mayur, Tambe Tejshri, and Shinde Sonali. "Overall Review On: Effective Therapeutic benefits of Microalgae: Spirulina." INTERNATIONAL JOURNAL OF CURRENT RESEARCH AND INNOVATIONS IN PHARMA SCIENCES 1, no. 1 (2023): 36–40. https://doi.org/10.5281/zenodo.8018148.

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Dehghani, Jaber, Khosro Adibkia, Ali Movafeghi, Mohammad M. Pourseif, and Yadollah Omidi. "Designing a new generation of expression toolkits for engineering of green microalgae; robust production of human interleukin-2." BioImpacts 10, no. 4 (2020): 259–68. http://dx.doi.org/10.34172/bi.2020.33.

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Introduction: Attributable to some critical features especially the similarity of the protein synthesis machinery between humans and microalgae, these microorganisms can be utilized for the expression of many recombinant proteins. However, low and unstable gene expression levels prevent the further development of microalgae biotechnology towards protein production. Methods: Here, we designed a novel "Gained Agrobacterium-2A plasmid for microalgae expression" (named GAME plasmid) for the production of the human interleukin-2 using three model microalgae, including Chlamydomonas reinhardtii, Chl

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Garcia-Parra, Jezabel, Claudio Fuentes-Grünewald, and Deyarina Gonzalez. "Therapeutic Potential of Microalgae-Derived Bioactive Metabolites Is Influenced by Different Large-Scale Culture Strategies." Marine Drugs 20, no. 10 (2022): 627. http://dx.doi.org/10.3390/md20100627.

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Microalgae have been identified as one of the most promising sources of novel bioactive compounds for biomedical applications, the food industry, and cosmetics. In the last decade, several biotechnological developments have facilitated the identification of a growing number of compounds as well as the study of optimal microalgae culture conditions for the production of biomass enriched in specific molecules of interest. In this study, two common commercial marine microalgae (Nannochloropsis oculata and Porphyridium purpureum) were cultured in standard and nutrient-stressed conditions and the o

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Tamel Selvan, Kartthigeen, Jo Aan Goon, Suzana Makpol, and Jen Kit Tan. "Effects of Microalgae on Metabolic Syndrome." Antioxidants 12, no. 2 (2023): 449. http://dx.doi.org/10.3390/antiox12020449.

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Metabolic syndrome (MetS) is a cluster of metabolic disturbances, including abdominal obesity, hypertension, hypertriglyceridemia, reduced high-density lipoprotein cholesterol (HDL-C) and hyperglycemia. Adopting a healthier lifestyle and multiple drug-based therapies are current ways to manage MetS, but they have limited efficacy, albeit the prevalence of MetS is rising. Microalgae is a part of the human diet and has also been consumed as a health supplement to improve insulin sensitivity, inflammation, and several components of MetS. These therapeutic effects of microalgae are attributed to t

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Barkia, Ines, Nazamid Saari, and Schonna R. Manning. "Microalgae for High-Value Products Towards Human Health and Nutrition." Marine Drugs 17, no. 5 (2019): 304. http://dx.doi.org/10.3390/md17050304.

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Microalgae represent a potential source of renewable nutrition and there is growing interest in algae-based dietary supplements in the form of whole biomass, e.g., Chlorella and Arthrospira, or purified extracts containing omega-3 fatty acids and carotenoids. The commercial production of bioactive compounds from microalgae is currently challenged by the biorefinery process. This review focuses on the biochemical composition of microalgae, the complexities of mass cultivation, as well as potential therapeutic applications. The advantages of open and closed growth systems are discussed, includin

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Olasehinde, Tosin, Ademola Olaniran, and Anthony Okoh. "Therapeutic Potentials of Microalgae in the Treatment of Alzheimer’s Disease." Molecules 22, no. 3 (2017): 480. http://dx.doi.org/10.3390/molecules22030480.

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Zhang, Qian, Yun Zeng, Yang Zhao, Xuqi Peng, En Ren, and Gang Liu. "Bio-Hybrid Magnetic Robots: From Bioengineering to Targeted Therapy." Bioengineering 11, no. 4 (2024): 311. http://dx.doi.org/10.3390/bioengineering11040311.

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Magnetic robots possess an innate ability to navigate through hard-to-reach cavities in the human body, making them promising tools for diagnosing and treating diseases minimally invasively. Despite significant advances, the development of robots with desirable locomotion and full biocompatibility under harsh physiological conditions remains challenging, which put forward new requirements for magnetic robots’ design and material synthesis. Compared to robots that are synthesized with inorganic materials, natural organisms like cells, bacteria or other microalgae exhibit ideal properties for in

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