Relevant bibliographies by topics / Microbeads; microtissue

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  1. Journal articles

Academic literature on the topic 'Microbeads; microtissue'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Microbeads; microtissue"

1

Soon, Chuan Wong, Fhong Soon Chin, Sek Tee Kian, Yean Leong Wai, Khairul Ahmad Mohd, and Ching Cheong Sok. "3D Oral Squamous Cell Carcinoma Microtissues Grown in Calcium Alginate Microbeads." Annual Research & Review in Biology 13, no. 4 (2017): 1–12. https://doi.org/10.9734/ARRB/2017/33526.

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3D microtissue models, especially cancer microtissue model, are potentially applicable for new drug testing because 3D microtissue reveals more realistic drug response, characterizes the disease and mimics the tumor in human body. In this paper, we report the integration of oral squamous cell carcinoma (OSCC) cell line (ORL-48) into 3D microtissue after two weeks of microencapsulation in calcium alginate microbeads that were produced based on the flicking technique. The microtissues contained highly proliferative cells as indicated by Alamar blue assay. The viable microtissues formed were extr
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2

Peterson, A. W., D. J. Caldwell, A. Y. Rioja, R. R. Rao, A. J. Putnam, and J. P. Stegemann. "Vasculogenesis and angiogenesis in modular collagen–fibrin microtissues." Biomater. Sci. 2, no. 10 (2014): 1497–508. http://dx.doi.org/10.1039/c4bm00141a.

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Vessel networks can be generated within modular protein microbeads containing endothelial cells and fibroblasts. Embedding these microtissues in a surrounding matrix emulates aspects of new blood vessel formation, a process that is critical in tissue development, remodeling, and regeneration.
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3

Wong, Soon, Chin Soon, Kian Tee, Wai Leong, Mohd Ahmad, and Sok Cheong. "3D Oral Squamous Cell Carcinoma Microtissues Grown in Calcium Alginate Microbeads." Annual Research & Review in Biology 13, no. 4 (2017): 1–12. http://dx.doi.org/10.9734/arrb/2017/33526.

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4

La Rocca, Alessia, Vincenza De Gregorio, Elena Lagreca, Raffaele Vecchione, Paolo Antonio Netti, and Giorgia Imparato. "Colorectal Cancer Bioengineered Microtissues as a Model to Replicate Tumor-ECM Crosstalk and Assess Drug Delivery Systems In Vitro." International Journal of Molecular Sciences 24, no. 6 (2023): 5678. http://dx.doi.org/10.3390/ijms24065678.

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Current 3D cancer models (in vitro) fail to reproduce complex cancer cell extracellular matrices (ECMs) and the interrelationships occurring (in vivo) in the tumor microenvironment (TME). Herein, we propose 3D in vitro colorectal cancer microtissues (3D CRC μTs), which reproduce the TME more faithfully in vitro. Normal human fibroblasts were seeded onto porous biodegradable gelatin microbeads (GPMs) and were continuously induced to synthesize and assemble their own ECMs (3D Stroma μTs) in a spinner flask bioreactor. Then, human colon cancer cells were dynamically seeded onto the 3D Stroma μTs
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5

Rudzinska-Radecka, Magdalena, Laura Turos-Korgul, Debjita Mukherjee, Paulina Podszywalow-Bartnicka, Katarzyna Piwocka, and Jan Guzowski. "High-throughput formulation of reproducible 3D cancer microenvironments for drug testing in myeloid leukemia." Biofabrication, December 2, 2024. https://doi.org/10.1088/1758-5090/ad998d.

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Abstract Leukemic microenvironment has been recognized as a factor that strongly supports the mechanisms of resistance. Therefore, targeting the microenvironment is currently one of the major directions in drug development and preclinical studies in leukemia. Despite the variety of available leukemia 3D culture models, the reproducible generation of miniaturized leukemic microenvironments, suitable for high-throughput drug testing, has remained a challenge. Here, we use droplet microfluidics to generate tens of thousands of highly monodisperse leukemic-bone marrow microenvironments within minu
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6

Scalzone, Annachiara, Giorgia Imparato, Francesco Urciuolo, and Paolo Antonio Netti. "Bioprinting of human dermal microtissues precursors as building blocks for endogenous in vitro connective tissue manufacturing." Biofabrication, April 4, 2024. http://dx.doi.org/10.1088/1758-5090/ad3aa5.

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Abstract The advent of 3D bioprinting technologies in tissue engineering has unlocked the potential to fabricate in vitro tissue models, overcoming the constraints associated with the shape limitations of preformed scaffolds. However, achieving an accurate mimicry of complex tissue microenvironments, encompassing cellular and biochemical components, and orchestrating their supramolecular assembly to form hierarchical structures while maintaining control over tissue formation, is crucial for gaining deeper insights into tissue repair and regeneration. Building upon our expertise in developing c
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7

Moya, Monica L., Yu-Hsiang Hsu, Christopher C. Hughes, Abraham P. Lee, and Steven C. George. "Abstract 17423: A Novel in vitro Platform of Perfused Human Microtissues for the Study of Neovascularization." Circulation 124, suppl_21 (2011). http://dx.doi.org/10.1161/circ.124.suppl_21.a17423.

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Understanding the process of vascular network formation and remodeling is key to designing effective strategies for the treatment of ischemic vascular diseases. Much of our current understanding of the neovascularization process is limited to in vivo studies, which require extrapolation of results to human, or in vitro models that lack the dynamic feature of perfusion. In this work we report the development of an in vitro model system of metabolically active microtissues that exchange nutrients and waste through perfused capillaries. For such design, a device consisting of 2 fluidic channels o
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