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Journal articles on the topic 'Microbial metabolites'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Nie, Siru, Ang Wang, Xiaohui Chen, Yuehua Gong, and Yuan Yuan. "Microbial-Related Metabolites May Be Involved in Eight Major Biological Processes and Represent Potential Diagnostic Markers in Gastric Cancer." Cancers 15, no. 21 (2023): 5271. http://dx.doi.org/10.3390/cancers15215271.

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Metabolites associated with microbes regulate human immunity, inhibit bacterial colonization, and promote pathogenicity. Integrating microbe and metabolome research in GC provides a direction for understanding the microbe-associated pathophysiological process of metabolic changes and disease occurrence. The present study included 30 GC patients with 30 cancerous tissues and paired non-cancerous tissues (NCs) as controls. LC-MS/MS metabolomics and 16S rRNA sequencing were performed to obtain the metabolic and microbial characteristics. Integrated analysis of the microbes and metabolomes was con

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Hernández, M. A. González, E. E. Canfora, and E. E. Blaak. "Faecal microbial metabolites of proteolytic and saccharolytic fermentation in relation to degree of insulin resistance in adult individuals." Beneficial Microbes 12, no. 3 (2021): 259–66. http://dx.doi.org/10.3920/bm2020.0179.

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The gut microbiota may affect host metabolic health through microbial metabolites. The balance between the production of microbial metabolites by saccharolytic and proteolytic fermentation may be an important determinant of metabolic health. Amongst the best-studied saccharolytic microbial metabolites are the short-chain fatty acids acetate, propionate and butyrate. However, human data on the role of other microbial fermentation by-products in metabolic health are greatly lacking. Therefore, we compared in a cross-sectional study the faecal microbial metabolites (caproate, lactate, valerate, s

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Shaffer, Justin P., Louis-Félix Nothias, Luke R. Thompson, et al. "Standardized multi-omics of Earth’s microbiomes reveals microbial and metabolite diversity." Nature Microbiology 7, no. 12 (2022): 2128–50. http://dx.doi.org/10.1038/s41564-022-01266-x.

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AbstractDespite advances in sequencing, lack of standardization makes comparisons across studies challenging and hampers insights into the structure and function of microbial communities across multiple habitats on a planetary scale. Here we present a multi-omics analysis of a diverse set of 880 microbial community samples collected for the Earth Microbiome Project. We include amplicon (16S, 18S, ITS) and shotgun metagenomic sequence data, and untargeted metabolomics data (liquid chromatography-tandem mass spectrometry and gas chromatography mass spectrometry). We used standardized protocols a

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Lee-Sarwar, Kathleen A., Jessica Lasky-Su, Rachel S. Kelly, Augusto A. Litonjua, and Scott T. Weiss. "Gut Microbial-Derived Metabolomics of Asthma." Metabolites 10, no. 3 (2020): 97. http://dx.doi.org/10.3390/metabo10030097.

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In this review, we discuss gut microbial-derived metabolites involved with the origins and pathophysiology of asthma, a chronic respiratory disease that is influenced by the microbiome. Although both gut and airway microbiomes may be important in asthma development, we focus here on the gut microbiome and metabolomic pathways involved in immune system ontogeny. Metabolite classes with existing evidence that microbial-derived products influence asthma risk include short chain fatty acids, polyunsaturated fatty acids and bile acids. While tryptophan metabolites and sphingolipids have known assoc

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Bérdy, János. "Bioactive Microbial Metabolites." Journal of Antibiotics 58, no. 1 (2005): 1–26. http://dx.doi.org/10.1038/ja.2005.1.

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6

Schmidt, Eric W. "Hunting microbial metabolites." Nature Chemistry 7, no. 5 (2015): 375–76. http://dx.doi.org/10.1038/nchem.2252.

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7

Marzouk, Amani M., and Galal T. Maatooq. "Microbial Metabolism of Danazol: A Contribution to Doping Analysis." Zeitschrift für Naturforschung C 69, no. 5-6 (2014): 245–52. http://dx.doi.org/10.5560/znc.2013-0135.

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Microbial metabolism of danazol (17α-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17ß-ol) by Beauveria bassiana ATCC 7159 and Glyocladium viride ATCC 10097 afforded four metabolites. The isolated metabolites were identified by different spectroscopic techniques as 6ß- hydroxy danazol, which is a not yet reported danazol metabolite, 17ß-hydroxy-17α-pregn-4-en- 20-yn-3-one (ethisterone) and 17ß-hydroxy-2α-(hydroxymethyl)-17α-pregn-4-en-20-yn-3-one (2α- hydroxymethyl ethisterone), which represent the major danazol metabolites detected in human urine. The last metabolite, 6ß,17ß-dihydroxy-2-(hydroxymethy

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8

Douglas, Angela E. "The microbial exometabolome: ecological resource and architect of microbial communities." Philosophical Transactions of the Royal Society B: Biological Sciences 375, no. 1798 (2020): 20190250. http://dx.doi.org/10.1098/rstb.2019.0250.

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All microorganisms release many metabolites, collectively known as the exometabolome. The resultant multi-way cross-feeding of metabolites among microorganisms distributes resources, thereby increasing total biomass of the microbial community, and promotes the recruitment and persistence of phylogenetically and functionally diverse taxa in microbial communities. Metabolite transfer can also select for evolutionary diversification, yielding multiple closely related but functionally distinct strains. Depending on starting conditions, the evolved strains may be auxotrophs requiring metabolic outp

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Foster, B. C., D. L. Wilson, T. Marwood, J. C. Ethier, and J. Zamecnik. "Microbial transformation of 3,4-methylenedioxy-N-methylamphetamine and 3,4-methylenedioxyamphetamine." Canadian Journal of Microbiology 42, no. 8 (1996): 851–54. http://dx.doi.org/10.1139/m96-107.

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The biotransformation of 3,4-methylenedioxy-N-methylarnphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) was examined in the fungus Cunninghamella echinulata. In addition to the reported mammalian metabolites (MDA, 3,4-methylenedioxybenzyl methyl ketoxime, 3,4-methylenedioxybenzyl methyl ketone) and the parent substrate, there were six novel metabolites detected. N-Acetyl-3,4-methylenedioxyamphetamine (NAcMDA) was unequivocally identified and three unidentified metabolites related to NAcMDA were also detected. N-Acetyl-3,4-methylenedioxy-1-phenyl-1-hydroxy-2-aminopropane was tentatively

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Kashyap, Bina, and Arja Kullaa. "Salivary Metabolites Produced by Oral Microbes in Oral Diseases and Oral Squamous Cell Carcinoma: A Review." Metabolites 14, no. 5 (2024): 277. http://dx.doi.org/10.3390/metabo14050277.

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In recent years, salivary metabolome studies have provided new biological information and salivary biomarkers to diagnose different diseases at early stages. The saliva in the oral cavity is influenced by many factors that are reflected in the salivary metabolite profile. Oral microbes can alter the salivary metabolite profile and may express oral inflammation or oral diseases. The released microbial metabolites in the saliva represent the altered biochemical pathways in the oral cavity. This review highlights the oral microbial profile and microbial metabolites released in saliva and its use

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11

Kuhnt, Michaela, Francis Bitsch, Monique Ponelle, Jean-Jacques Sanglier, Ying Wang, and Barbara Wolff. "Microbial Conversion Products of Leptomycin B." Applied and Environmental Microbiology 64, no. 2 (1998): 714–20. http://dx.doi.org/10.1128/aem.64.2.714-720.1998.

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ABSTRACT Leptomycin B (LMB), a secondary metabolite produced byStreptomyces sp. strain ATS 1287, with known antifungal and antitumor effects, inhibits the nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 regulatory protein Rev and exhibits significant antiproliferative activity. Since LMB itself turned out to be distinctly cytotoxic, a bioconversion screening with a selected set of 29 bacterial and 72 fungal strains was performed in order to obtain metabolites of LMB with reduced antiproliferative effects. Several derivatives of LMB, more polar than the parent compou

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Al-Khazaleh, Ahmad K., Dennis Chang, Gerald W. Münch, and Deep Jyoti Bhuyan. "The Gut Connection: Exploring the Possibility of Implementing Gut Microbial Metabolites in Lymphoma Treatment." Cancers 16, no. 8 (2024): 1464. http://dx.doi.org/10.3390/cancers16081464.

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Recent research has implicated the gut microbiota in the development of lymphoma. Dysbiosis of the gut microbial community can disrupt the production of gut microbial metabolites, thereby impacting host physiology and potentially contributing to lymphoma. Dysbiosis-driven release of gut microbial metabolites such as lipopolysaccharides can promote chronic inflammation, potentially elevating the risk of lymphoma. In contrast, gut microbial metabolites, such as short-chain fatty acids, have shown promise in preclinical studies by promoting regulatory T-cell function, suppressing inflammation, an

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Liu, Yanbo, Junyi Wu, Haideng Li, et al. "Combined microbiome and metabolomics analysis of Taorong-type baijiu high-temperature Daqu and medium-temperature Daqu." PeerJ 11 (January 3, 2024): e16621. http://dx.doi.org/10.7717/peerj.16621.

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Background Daqu is an essential starter for baijiu brewing in China. However, the microbial enrichment and metabolic characteristics of Daqu formed at different fermentation temperatures are still unclear. Methods High-throughput sequencing technology and the non-targeted metabolomics were used to compare the microbial communities and metabolites of Taorong-type high-temperature Daqu and middle-temperature Daqu. In this study, the relationship between microorganisms and metabolites was established. Results The study found that the composition and metabolites of the microbial community differed

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Nguyen, Sang Minh, Huong T. Tran, Danxia Yu, et al. "Abstract LB149: Predicted gut microbial metabolites and chemotherapy induced toxicity among breast cancer patients." Cancer Research 85, no. 8_Supplement_2 (2025): LB149. https://doi.org/10.1158/1538-7445.am2025-lb149.

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Abstract Gut microbial metabolites may be the key hubs connecting the gut microbiota and chemotherapy responses. Little research has investigated the associations between gut microbial metabolites and chemotherapy-induced toxicity, particularly among breast cancer patients. In a prospective study involving 300 chemotherapy-treated breast cancer patients, shotgun metagenomic sequencing was carried out for pre-chemotherapy stool samples. A gut bioactive metabolite profile of 79 gut metabolites was predicted using MelonnPan, a machine-learning approach with proven reliability. Chemotherapy-induce

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Nguyen, Don D., Veronika Saharuka, Vitaly Kovalev, et al. "Facilitating Imaging Mass Spectrometry of Microbial Specialized Metabolites with METASPACE." Metabolites 11, no. 8 (2021): 477. http://dx.doi.org/10.3390/metabo11080477.

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Metabolite annotation from imaging mass spectrometry (imaging MS) data is a difficult undertaking that is extremely resource intensive. Here, we adapted METASPACE, cloud software for imaging MS metabolite annotation and data interpretation, to quickly annotate microbial specialized metabolites from high-resolution and high-mass accuracy imaging MS data. Compared with manual ion image and MS1 annotation, METASPACE is faster and, with the appropriate database, more accurate. We applied it to data from microbial colonies grown on agar containing 10 diverse bacterial species and showed that METASP

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Wang, Haibo, Jinshun Zhan, Haoyun Jiang, et al. "Metagenomics-Metabolomics Exploration of Three-Way-Crossbreeding Effects on Rumen to Provide Basis for Crossbreeding Improvement of Sheep Microbiome and Metabolome of Sheep." Animals 14, no. 15 (2024): 2256. http://dx.doi.org/10.3390/ani14152256.

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The objective of this experiment was to explore the effects of three-way hybridization on rumen microbes and metabolites in sheep using rumen metagenomics and metabolomics. Healthy Hu and CAH (Charolais × Australian White × Hu) male lambs of similar birth weight and age were selected for short-term fattening after intensive weaning to collect rumen fluid for sequencing. Rumen metagenomics diversity showed that Hu and CAH sheep were significantly segregated at the species, KEGG-enzyme, and CAZy-family levels. Moreover, the CAH significantly increased the ACE and Chao1 indices. Further, correlat

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Fan, Simiao, Yaxin Li, Shaoyi Huang, et al. "Microbiota-Derived L-SeMet Potentiates CD8+ T Cell Effector Functions and Facilitates Anti-Tumor Responses." International Journal of Molecular Sciences 26, no. 6 (2025): 2511. https://doi.org/10.3390/ijms26062511.

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Extensive studies have shown that gut microbiota-derived metabolites can enhance the antitumor efficacy of immunotherapy by modulating host immune responses. However, the more comprehensive spectrum of such metabolites and their mechanisms remain unclear. In this study, we demonstrated that L-selenomethionine (L-SeMet), a gut microbial metabolite, acts as a positive regulator of immunotherapy. Through screening of a repository of gut microbial metabolites, we identified that L-SeMet can effectively enhance the effector function of CD8+ T cells. Furthermore, intragastric administration of L-SeM

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18

BĚHAL, V. "Biosynthesis control of microbial metabolites." Kvasny Prumysl 31, no. 7 (1985): 157–59. http://dx.doi.org/10.18832/kp1985030.

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Agulló, Vicente, Claudia Favari, Niccolò Pilla, et al. "Using Targeted Metabolomics to Unravel Phenolic Metabolites of Plant Origin in Animal Milk." International Journal of Molecular Sciences 25, no. 8 (2024): 4536. http://dx.doi.org/10.3390/ijms25084536.

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Milk holds a high nutritional value and is associated with diverse health benefits. The understanding of its composition of (poly)phenolic metabolites is limited, which necessitates a comprehensive evaluation of the subject. This study aimed at analyzing the (poly)phenolic profile of commercial milk samples from cows and goats and investigating their sterilization treatments, fat content, and lactose content. Fingerprinting of phenolic metabolites was achieved by using ultra-high-performance liquid chromatography coupled with triple-quadrupole mass spectrometry (UHPLC-QqQ-MS/MS). Two hundred a

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Puschhof, Jens, and Cynthia L. Sears. "Microbial metabolites damage DNA." Science 378, no. 6618 (2022): 358–59. http://dx.doi.org/10.1126/science.ade6952.

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21

Běhal, V. "Nontraditional microbial bioactive metabolites." Folia Microbiologica 46, no. 5 (2001): 363–70. http://dx.doi.org/10.1007/bf02814422.

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22

Erum, Saira, Sadia Sultan, Syed Adnan Ali Shah, Muhammad Ashraf, and Muhammad Iqbal Choudhary. "MICROBIAL OXIDATION OF FINASTERIDE WITH MACROPHOMINA PHASEOLINA(KUCC 730)." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 10 (2017): 17. http://dx.doi.org/10.22159/ijpps.2017v9i11.13576.

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Objectives: New microbial oxidative derivatives of Finasteride [17β-(N-tert-butylcarbamoyl)-4-aza-5α-androst-1-en-3-one] (1) has been investigated with Macrophomina phaseolina (ATCC730).Methods: Fermented media of Macrophomina phaseolina (ATCC730) was prepared to cultivate the fungal cultures . Substrate 1 was incubated in liquid media for 16 days. After sixteen days, filtration and extraction of the fermented media was carried out with 9 L DCM in three portions. Resulting organic extract was dried using anhydrous (Na2SO4), and evaporated to afford a brown gum (950 mg). This on chromatographic

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Sedaca, Albetina. "Urgency and Mechanism of Biosynthesis of Marine Microbial Secondary Metabolites." International Journal of Science and Society 2, no. 4 (2020): 159–66. http://dx.doi.org/10.54783/ijsoc.v2i4.201.

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Marine microorganism is one of biologically active potential resources of secondary metabolites. Its potency are so promising that the knowledge of how its secondary metabolite occured need to be studied and collected. Those knowledges will enable further study is improving secondary metabolite production in the laboratory. In nature, secondary metabolites synthesis occur when there are effect of both biotic and abiotic factors such as sea water and microbe symbiosis with other living materials. When this is explained in metabolic pathways, secondary metabolite synthesis affected by available

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Edward Amado. "Urgency and Mechanism of Biosynthesis of Marine Microbial Secondary Metabolites." INFLUENCE : International Journal of Science Review 3, no. 3 (2021): 229–34. http://dx.doi.org/10.54783/influence.v3i3.181.

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Marine microorganism is one of biologically active potential resources of secondary metabolites. Its potency are so promising that the knowledge of how its secondary metabolite occured need to be studied and collected. Those knowledges will enable further study is improving secondary metabolite production in the laboratory. In nature, secondary metabolites synthesis occur when there are effect of both biotic and abiotic factors such as sea water and microbe symbiosis with other living materials. When this is explained in metabolic pathways, secondary metabolite synthesis affected by available

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Osada, Hiroyuki, and Toshihiko Nogawa. "Systematic isolation of microbial metabolites for natural products depository (NPDepo)." Pure and Applied Chemistry 84, no. 6 (2011): 1407–20. http://dx.doi.org/10.1351/pac-con-11-08-11.

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A microbial fraction library has been constructed as a part of RIKEN Natural Products Depository (NPDepo) to discover and isolate novel metabolites with unique biological activity from microbial sources efficiently and rapidly. The fraction library was made by a systematic separation method based on basic chromatographic techniques. Each fraction in the library was analyzed by liquid chromatography/mass spectrometry (LC/MS) to reveal physicochemical properties of each metabolite within the fraction, and the results were applied to construct a database for rapid discovery of novel and structura

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Luo, Wenfang, Xingxing Ping, Junhui Zhou, et al. "Alternaria alternata JTF001 Metabolites Recruit Beneficial Microorganisms to Reduce the Parasitism of Orobanche aegyptiaca in Tomato." Biology 14, no. 2 (2025): 116. https://doi.org/10.3390/biology14020116.

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Orobanche aegyptiaca is a holoparasitic weed that extracts water, nutrients, and growth regulators from host plants, leading to significant yield and quality losses. Biocontrol microbial metabolites have been shown to enhance plant resistance against parasitic plants, yet the underlying microbial mechanisms remain poorly understood. In this study, we investigated the role of Alternaria alternata JTF001 (J1) microbial metabolites in recruiting beneficial microbes to the tomato rhizosphere and promoting the establishment of a disease-suppressive microbiome. Pot experiments revealed that J1 metab

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Sponchiado, Rafaela, Julia Sorrentino, Letícia M. Cordenonsi, et al. "Rifampicin: biotransformation study using the fungus Cunninghamella elegans and monitoring through UHPLC-MS." Drug Analytical Research 4, no. 1 (2020): 44–48. http://dx.doi.org/10.22456/2527-2616.101989.

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Drug biotransformation studies appear as an alternative to pharmacological investigations of metabolites, development of new drug candidates with reduced investment and most efficient production. The objective of this study was to evaluate the capacity of biotransformation of Rifampicin (RIF) by the filamentous fungus Cunninghamella elegans as a microbial model of mammalian metabolism. In 120 h, C. elegans transformed the drug into the following two metabolites: rifampicin quinone and novel metabolite. The products of rifampicin formed in vitro were monitored by HPLC-PDA, being identified thro

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Firat, Zeynep, Fatih Demirci, Betül Demirci, Hasan Kırmızıbekmez та K. Hüsnü C. Baser. "Microbial Transformation of (–)-α-Bisabolol Towards Bioactive Metabolites". Records of Natural Products 15, № 6 (2021): 593–601. http://dx.doi.org/10.25135/rnp.252.2004.1615.

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Bisabolol is one of the bioactive constituents of chamomile. It was aimed to biotransform (–)-α-bisabolol by different fungi for the production of new bioactive metabolites, which was converted to α-bisabolol oxide A and B by Thamnidium elegans. Additionally, the biotransformation by Penicillium neocrassum yielded a new metabolite, which was characterized as 2-(5-methyl-5-(6-methyl-7-oxabicyclo[4.1.0]heptan-3-yl)tetrahydrofuran-2-yl)propan-2-ol = bisafuranol. The substrate and its metabolite mixtures were tested using antioxidant DPPH• scavenging assay. Antimicrobial activity was evaluated by

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Atreya, Suchita. "Underexploited benefits of microbial secondary metabolites: Major challenges a review." IP International Journal of Medical Microbiology and Tropical Diseases 9, no. 3 (2023): 139–44. http://dx.doi.org/10.18231/j.ijmmtd.2023.028.

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Secondary metabolites (SMs) are naturally occurring compounds produced mostly by bacteria, fungus, and plants. They are low-molecular-weight compounds with a wide range of chemical structures and biological functions. In contrast to main metabolites such as lipids, amino acids, carbohydrates, and nucleic acids, the name secondary metabolite comes from the discovery that their creation is not required for organism growth and reproduction. SMs, on the other hand, are far from secondary, and the term "specialised metabolites" is being used to characterise them. Organic chemists, molecular biologi

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Zhao, Haobin, Di Wang, Zhifu Zhang, Junfang Xian, and Xiaosu Bai. "Effect of Gut Microbiota-Derived Metabolites on Immune Checkpoint Inhibitor Therapy: Enemy or Friend?" Molecules 27, no. 15 (2022): 4799. http://dx.doi.org/10.3390/molecules27154799.

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The human gut is inhabited by hundreds of billions of commensal microbiota that collectively produce thousands of small molecules and metabolites with local and systemic effects on the physiology of the host. Much evidence from preclinical to clinical studies has gradually confirmed that the gut microbiota can regulate anti-tumor immunity and affect the efficacy of cancer immune checkpoint inhibitors (ICIs) therapy. In particular, one of the main modes of gut microbiota regulating anti-tumor immunity is through metabolites, which are small molecules that can be transported in the body and act

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Jiang, L., M. Guo, G. Ruan, et al. "DOP123 Linking microbial genes to mucosal metabolites uncovers host-microbial interactions during 5-ASA therapy for ulcerative colitis." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i305. https://doi.org/10.1093/ecco-jcc/jjae190.0162.

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Abstract Background The severity of ulcerative colitis (UC) depends on the state of the colon mucosa, where achieving mucosal remission markedly improves patient prognosis and quality of life. The study aimed to characterize essential mucosal metabolites and microbial gene involved in UC remission, and to elucidate the mechanisms by which specific metabolites regulate intestinal homeostasis. Methods An integrated metagenomic and metabolomic analysis was conducted to elucidate the correlation between disease-associated microbes and host mucosal metabolites. Participants included non-UC controls

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Higgs, Richard E., James A. Zahn, Jeffrey D. Gygi, and Matthew D. Hilton. "Rapid Method To Estimate the Presence of Secondary Metabolites in Microbial Extracts." Applied and Environmental Microbiology 67, no. 1 (2001): 371–76. http://dx.doi.org/10.1128/aem.67.1.371-376.2001.

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ABSTRACT Screening microbial secondary metabolites is an established method to identify novel biologically active molecules. Preparation of biological screening samples from microbial fermentation extracts requires growth conditions that promote synthesis of secondary metabolites and extraction procedures that capture the secondary metabolites produced. High-performance liquid chromatography (HPLC) analysis of fermentation extracts can be used to estimate the number of secondary metabolites produced by microorganisms under various growth conditions but is slow. In this study we report on a rap

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Boysen, Jana M., Nauman Saeed, and Falk Hillmann. "Natural products in the predatory defence of the filamentous fungal pathogen Aspergillus fumigatus." Beilstein Journal of Organic Chemistry 17 (July 28, 2021): 1814–27. http://dx.doi.org/10.3762/bjoc.17.124.

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The kingdom of fungi comprises a large and highly diverse group of organisms that thrive in diverse natural environments. One factor to successfully confront challenges in their natural habitats is the capability to synthesize defensive secondary metabolites. The genetic potential for the production of secondary metabolites in fungi is high and numerous potential secondary metabolite gene clusters have been identified in sequenced fungal genomes. Their production may well be regulated by specific ecological conditions, such as the presence of microbial competitors, symbionts or predators. Here

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Lai, Xianjun, Haiyan Wang, Rui Peng, Zihan Chen, Yuxin Xiang, and Lang Yan. "Different Commercial Microbial Additives Influence Fermentation Quality and Microbial Community of King Grass Silage." Fermentation 11, no. 5 (2025): 264. https://doi.org/10.3390/fermentation11050264.

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The microbiota in forage silage plays a pivotal role in determining the fermentation quality. Identifying effective microbial additives is essential to help forage producers refine their search for functional inoculants and to support farmers in adopting them for practical ensiling. This study investigated microbial and metabolomic dynamics in king grass silages treated with six commercial inoculants dominated by Enterococcus faecium-like species, Bacillus velezensis, and Lactobacillus paraplantarum. The fermentation characteristics, viable microbial diversity, and metabolite profiles were com

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Choudhary, Muhammad I., Syed G. Musharraf, Rahat A. Ali, Muhammad Atif та Atta-ur Rahman. "Microbial Transformation of Antifertility Agents, Norethisterone and 17α-Ethynylestradiol". Zeitschrift für Naturforschung B 59, № 3 (2004): 319–23. http://dx.doi.org/10.1515/znb-2004-0314.

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The microbial transformation of oral contraceptive norethisterone (1) by Cephalosporium aphidicola afforded an oxidized metabolite, 17α-ethynylestradiol (2), while the microbial transformation of 2 by Cunninghamella elegans yielded several metabolites, 19-nor-17α-pregna-1,3,5 (10)- trien-20-yne-3,4,17β -triol (3), 19-nor-17α-pregna-1,3,5 (10)-trien-20-yne-3,7α,17β -triol (4), 19- nor-17α-pregna-1,3,5 (10)-trien-20-yne-3,11α,17β -triol (5), 19-nor-17α-pregna-1,3,5 (10)-trien-20- yne-3,6β ,17β -triol (6) and 19-nor-17α-pregna-1,3,5 (10)-trien-20-yne-3,17β -diol-6β -methoxy (7). Metabolite 7 was

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Hamer, Henrike M., Vicky De Preter, Karen Windey, and Kristin Verbeke. "Functional analysis of colonic bacterial metabolism: relevant to health?" American Journal of Physiology-Gastrointestinal and Liver Physiology 302, no. 1 (2012): G1—G9. http://dx.doi.org/10.1152/ajpgi.00048.2011.

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With the use of molecular techniques, numerous studies have evaluated the composition of the intestinal microbiota in health and disease. However, it is of major interest to supplement this with a functional analysis of the microbiota. In this review, the different approaches that have been used to characterize microbial metabolites, yielding information on the functional end products of microbial metabolism, have been summarized. To analyze colonic microbial metabolites, the most conventional way is by application of a hypothesis-driven targeted approach, through quantification of selected me

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Tang, Jing, Qingqing Huang, Qian Wang, et al. "The Comprehensive Root Metabolite–Rhizomicrobiota Response Patterns of Rhododendron delavayi (R. delavayi) to Waterlogging Stress and Post–Waterlogging Recovery." Horticulturae 11, no. 7 (2025): 770. https://doi.org/10.3390/horticulturae11070770.

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Waterlogging is a critical abiotic stressor that significantly impacts plant growth. Plants under waterlogging stress release metabolic signals that recruit rhizosphere microorganisms and enhance stress resistance. However, the mechanisms through which the non-adaptive species R. delavayi responds to waterlogging stress via the synergistic interaction between root metabolites and rhizosphere microbiota remain poorly elucidated. Here, we employed pot experiments to characterize the responses of the root metabolite–microbiota complex in R. delavayi during waterlogging stress and subsequent recov

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Haubrich, Brad. "Microbial Sterolomics as a Chemical Biology Tool." Molecules 23, no. 11 (2018): 2768. http://dx.doi.org/10.3390/molecules23112768.

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Metabolomics has become a powerful tool in chemical biology. Profiling the human sterolome has resulted in the discovery of noncanonical sterols, including oxysterols and meiosis-activating sterols. They are important to immune responses and development, and have been reviewed extensively. The triterpenoid metabolite fusidic acid has developed clinical relevance, and many steroidal metabolites from microbial sources possess varying bioactivities. Beyond the prospect of pharmacognostical agents, the profiling of minor metabolites can provide insight into an organism’s biosynthesis and phylogeny

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Iyer, Namrata, and Sinéad C. Corr. "Gut Microbial Metabolite-Mediated Regulation of the Intestinal Barrier in the Pathogenesis of Inflammatory Bowel Disease." Nutrients 13, no. 12 (2021): 4259. http://dx.doi.org/10.3390/nu13124259.

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Inflammatory bowel disease (IBD) is a chronic inflammatory disease. The disease has a multifactorial aetiology, involving genetic, microbial as well as environmental factors. The disease pathogenesis operates at the host–microbe interface in the gut. The intestinal epithelium plays a central role in IBD disease pathogenesis. Apart from being a physical barrier, the epithelium acts as a node that integrates environmental, dietary, and microbial cues to calibrate host immune response and maintain homeostasis in the gut. IBD patients display microbial dysbiosis in the gut, combined with an increa

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Li, Yi, Yuanyuan Guan, Zhengchu Jiang, et al. "Soil Microbial and Metabolomic Shifts Induced by Phosphate-Solubilizing Bacterial Inoculation in Torreya grandis Seedlings." Plants 13, no. 22 (2024): 3209. http://dx.doi.org/10.3390/plants13223209.

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Phosphorus is crucial for plant growth and development, but excess fertilizer not absorbed by plants often binds with metal ions like iron and manganese, forming insoluble compounds that contribute to soil environmental pollution. This study investigates the impact of Burkholderia sp., a phosphate-solubilizing bacterium utilized as a biofertilizer, on the fertility of T. grandis soil, alongside the associated shifts in soil metabolites and their relationship with microbial communities after inoculation. The soil microbial community structures and metabolite profiles were analyzed via amplicon

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Koopen, Annefleur M., Nicolien C. de Clercq, Moritz V. Warmbrunn, et al. "Plasma Metabolites Related to Peripheral and Hepatic Insulin Sensitivity Are Not Directly Linked to Gut Microbiota Composition." Nutrients 12, no. 8 (2020): 2308. http://dx.doi.org/10.3390/nu12082308.

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Plasma metabolites affect a range of metabolic functions in humans, including insulin sensitivity (IS). A subset of these plasma metabolites is modified by the gut microbiota. To identify potential microbial–metabolite pathways involved in IS, we investigated the link between plasma metabolites, gut microbiota composition, and IS, using the gold-standard for peripheral and hepatic IS measurement in a group of participants with metabolic syndrome (MetSyn). In a cross-sectional study with 115 MetSyn participants, fasting plasma samples were collected for untargeted metabolomics analysis and feca

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Marfil-Santana, Miguel David, Anahí Martínez-Cárdenas, Analuisa Ruíz-Hernández, et al. "A Meta-Omics Analysis Unveils the Shift in Microbial Community Structures and Metabolomics Profiles in Mangrove Sediments Treated with a Selective Actinobacterial Isolation Procedure." Molecules 26, no. 23 (2021): 7332. http://dx.doi.org/10.3390/molecules26237332.

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Mangrove sediment ecosystems in the coastal areas of the Yucatan peninsula are unique environments, influenced by their karstic origin and connection with the world’s largest underground river. The microbial communities residing in these sediments are influenced by the presence of mangrove roots and the trading chemistry for communication between sediment bacteria and plant roots can be targeted for secondary metabolite research. To explore the secondary metabolite production potential of microbial community members in mangrove sediments at the “El Palmar” natural reserve in Sisal, Yucatan, a

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Bron, Peter A., Marta Catalayud, Massimo Marzorati, et al. "Delivery of Metabolically Neuroactive Probiotics to the Human Gut." International Journal of Molecular Sciences 22, no. 17 (2021): 9122. http://dx.doi.org/10.3390/ijms22179122.

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The human microbiome is a rich factory for metabolite production and emerging data has led to the concept that orally administered microbial strains can synthesize metabolites with neuroactive potential. Recent research from ex vivo and murine models suggests translational potential for microbes to regulate anxiety and depression through the gut-brain axis. However, so far, less emphasis has been placed on the selection of specific microbial strains known to produce the required key metabolites and the formulation in which microbial compositions are delivered to the gut. Here, we describe a do

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F, Luziatelli, Nobili A, Nardilli F, and Ruzzi M. "Importance of Microbial Exo-Metabolites as Postbiotics for Sustainable Agriculture." Open Access Journal of Microbiology & Biotechnology 8, no. 1 (2023): 1–4. http://dx.doi.org/10.23880/oajmb-16000257.

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Plant growth-promoting (PGP) microorganisms are bacteria and fungi associated with the plant holobiont that can positively affect the health and growth of plants. Their beneficial activity is associated with a mixture of organic compounds produced and released outside the cell, including phytohormones such as auxins and auxin-related compounds. This mini-review describes the importance of using microbial exo-metabolites as postbiotics for developing innovative second-generation plant biostimulants for sustainable agriculture.

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den Hartog, Ilona, Laura B. Zwep, Stefan M. T. Vestjens, et al. "Metabolomic profiling of microbial disease etiology in community-acquired pneumonia." PLOS ONE 16, no. 6 (2021): e0252378. http://dx.doi.org/10.1371/journal.pone.0252378.

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Diagnosis of microbial disease etiology in community-acquired pneumonia (CAP) remains challenging. We undertook a large-scale metabolomics study of serum samples in hospitalized CAP patients to determine if host-response associated metabolites can enable diagnosis of microbial etiology, with a specific focus on discrimination between the major CAP pathogen groups S. pneumoniae, atypical bacteria, and respiratory viruses. Targeted metabolomic profiling of serum samples was performed for three groups of hospitalized CAP patients with confirmed microbial etiologies: S. pneumoniae (n = 48), atypic

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Ballan, Rafael, and Susana Marta Isay Saad. "Characteristics of the Gut Microbiota and Potential Effects of Probiotic Supplements in Individuals with Type 2 Diabetes mellitus." Foods 10, no. 11 (2021): 2528. http://dx.doi.org/10.3390/foods10112528.

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The increasing prevalence of type 2 diabetes mellitus (T2DM) worldwide has become a burden to healthcare systems. In 2019, around 463 million adults were living with diabetes mellitus, and T2DM accounted for 90 to 95% of cases. The relationship between the gut microbiota and T2DM has been explored with the advent of metagenomic techniques. Genome-wide association studies evaluating the microbiota of these individuals have pointed to taxonomic, functional, and microbial metabolite imbalances and represent a potential intervention in T2DM management. Several microbial metabolites and components,

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Han, Fubo, Yina Xiao, and Ik-Soo Lee. "Microbial Conjugation Studies of Licochalcones and Xanthohumol." International Journal of Molecular Sciences 22, no. 13 (2021): 6893. http://dx.doi.org/10.3390/ijms22136893.

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Microbial conjugation studies of licochalcones (1–4) and xanthohumol (5) were performed by using the fungi Mucor hiemalis and Absidia coerulea. As a result, one new glucosylated metabolite was produced by M. hiemalis whereas four new and three known sulfated metabolites were obtained by transformation with A. coerulea. Chemical structures of all the metabolites were elucidated on the basis of 1D-, 2D-NMR and mass spectroscopic data analyses. These results could contribute to a better understanding of the metabolic fates of licochalcones and xanthohumol in mammalian systems. Although licochalco

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Pirog, T. P. "MICROBIAL CO-CULTIVATION: DISCOVERY OF NOVEL SECONDARY METABOLITES WITH DIFFERENT BIOLOGICAL ACTIVITIES." Biotechnologia Acta 16, no. 1 (2023): 21–39. http://dx.doi.org/10.15407/biotech16.01.021.

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In recent decades, overuse and misuse of antibiotics as well as social and economic factors have accelerated the spread of antibiotic-resistant bacteria, making them a major problem for humanity. One of the most effective approaches to the discovery of new secondary antimicrobial metabolites is co-cultivation of microorganisms, in which the producer of the target products is grown together with competitive microorganisms ( inductors), in response to the presence of which silent biosynthetic genes of the producer strain are activated and an increase in the biological activity of the synthesized

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Kondrashevska, K., I. Kliuchka, T. Pirog, and Yu Penchuk. "DIVERSITY OF MICROBIAL SECONDARY METABOLITES." Scientific Works of National University of Food Technologies 24, no. 5 (2018): 44–60. http://dx.doi.org/10.24263/2225-2924-2018-24-5-8.

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Muller, Efrat, Yadid M. Algavi, and Elhanan Borenstein. "A meta-analysis study of the robustness and universality of gut microbiome-metabolome associations." Microbiome 9, no. 1 (2021). http://dx.doi.org/10.1186/s40168-021-01149-z.

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Abstract Background Microbiome-metabolome studies of the human gut have been gaining popularity in recent years, mostly due to accumulating evidence of the interplay between gut microbes, metabolites, and host health. Statistical and machine learning-based methods have been widely applied to analyze such paired microbiome-metabolome data, in the hope of identifying metabolites that are governed by the composition of the microbiome. Such metabolites can be likely modulated by microbiome-based interventions, offering a route for promoting gut metabolic health. Yet, to date, it remains unclear wh

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