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Journal articles on the topic 'Microbiology|Immunology|Oncology'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Wertel, Iwona, Wiesława Bednarek, Artur Czekierdowski, and Jan Kotarski. "Ovarian cancer: early detection, angiogenesis, lymphangiogenesis and current prospects for therapy." Polish Journal of Public Health 125, no. 1 (2015): 24–28. http://dx.doi.org/10.1515/pjph-2015-0017.

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AbstractI Chair and Department of Gynecological Oncology and Gynecology is a specialist research center providing help in diagnostics and treatment of gynecological malignancies. The research work is focused on the processes of angiogenesis and lymphangiogenesis. Development of blood and lymphatic vessels is subject to research in a wide range of malignancies, including ovarian cancer, endometrial cancer and uterine sarcomas. Angiogenesis in malignancies of the female genital tract is investigated by using some modern 3D sonography that uses high-definition blood flow imaging. Ovarian Tumors a

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Ogino, Shuji, Jonathan A. Nowak, Tsuyoshi Hamada, et al. "Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine." Gut 67, no. 6 (2018): 1168–80. http://dx.doi.org/10.1136/gutjnl-2017-315537.

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Immunotherapy strategies targeting immune checkpoints such as the CTLA4 and CD274 (programmed cell death 1 ligand 1, PD-L1)/PDCD1 (programmed cell death 1, PD-1) T-cell coreceptor pathways are revolutionising oncology. The approval of pembrolizumab use for solid tumours with high-level microsatellite instability or mismatch repair deficiency by the US Food and Drug Administration highlights promise of precision immuno-oncology. However, despite evidence indicating influences of exogenous and endogenous factors such as diet, nutrients, alcohol, smoking, obesity, lifestyle, environmental exposur

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Berman, Jason. "Model organisms—the critical link between gene discovery and therapeutic intervention." Clinical and Investigative Medicine 41 (November 3, 2018): 21–23. http://dx.doi.org/10.25011/cim.v41i2.31422.

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Jason graduated from the University of Toronto Medical School in 1997 followed by a pediatric residency at the Hospital for Sick Children, a fellowship in pediatric hematology/oncology at Boston Children’s Hospital and post-doctoral training at the Dana-Farber Cancer Institute. He is a professor at Dalhousie University in the Departments of Pediatrics, Microbiology and Immunology and Pathology, was appointed as the director of the Clinician Investigator Program (CIP) and the Graduate Program in Medical Research at Dalhousie (2014), elected president of the Canadian Society for Clinical Investi

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Md Dipu Ahmed, Kazi M Maraz, Shahirin Shahida, Tarannum Dihan, and Ruhul A Khan. "A review on the synthesis, surface modification and drug delivery of nanoparticles." Global Journal of Engineering and Technology Advances 8, no. 2 (2021): 032–45. http://dx.doi.org/10.30574/gjeta.2021.8.2.0114.

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Over the past few years, the evolution of nanotechnology has extended into a wide range of applications. Nanotechnology has now become a multidisciplinary science that applies to electronics, materials science, biomedical engineering, microbiology, etc. Recently, nanotechnology is being used in biomedical and pharmaceutical science. Among them drug delivery is set to spread rapidly. Application of nanotechnology in health sector also created a potential impact such as in the fields of immunology, cardiology, endocrinology, ophthalmology, and oncology. Nanoparticles are unique because of their

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Uchida, Shumpei, Makiko Uemura, Osamu Imataki, and Norimitsu Kadowaki. "Strain-Specific Transmission in an Outbreak of ESBL-Producing Enterobacteriaceae in a Medical Oncology and Immunology Care Unit." Blood 126, no. 23 (2015): 5632. http://dx.doi.org/10.1182/blood.v126.23.5632.5632.

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Abstract Background Extended-spectrum b-lactamase (ESBL)-producing bacteria are resistant to several types of antibiotics excluding carbapenems. Consequently, infections caused by ESBL-producing bacteria are difficult to treat. Especially for the immunocompromised including hematologic malignancies ESBL-producing bacteria are emergent pathogens. In addition, there are no evidence-based guidelines specifying the infection control for ESBL-producing bacterial outbreak. Along with the recent trend of wide spreading ESBL genes in the community, carriers ESBL-producing bacteria in the community bec

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Li, Geling, and Hal E. Broxmeyer. "M-CSF Drives Human Cord Blood Monocyte Differentiation along an Alternative Pathway into Suppressive CXCR4highIL-10highIL-12absentTNF-adefective Dendritic Cells." Blood 104, no. 11 (2004): 3446. http://dx.doi.org/10.1182/blood.v104.11.3446.3446.

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Abstract M-CSF Drives Human Cord Blood Monocyte Differentiation along an Alternative Pathway into Suppressive CXCR4highIL-10highIL-12absentTNF-αdefective Dendritic cells Geling Li and Hal E. Broxmeyer. Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA; Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN, USA; Walther Cancer Institute, Indianapolis, IN, USA Macrophage colony-stimulating factor (M-CSF) in cooperation with TGF-β1 induces CD34+ hematopoietic progenitor cells to differentiate into Langerhans cells, a subset of imm

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DE LENCASTRE, H., A. E. BROWN, M. CHUNG, D. ARMSTRONG, and A. TOMASZ. "Role of Transposon Tn5482in the Epidemiology of Vancomycin-ResistantEnterococcus faeciumin the Pediatric Oncology Unit of a New York City Hospital." Microbial Drug Resistance 5, no. 2 (1999): 113–29. http://dx.doi.org/10.1089/mdr.1999.5.113.

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Cornejo-Juárez, Patricia, Patricia Volkow-Fernández, Jose Sifuentes-Osornio, et al. "Tracing the Source of an Outbreak of Methicillin-ResistantStaphylococcus aureusin a Tertiary-Care Oncology Hospital by Epidemiology and Molecular Methods." Microbial Drug Resistance 16, no. 3 (2010): 203–8. http://dx.doi.org/10.1089/mdr.2010.0048.

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KUNOVA, A., J. TRUPL, A. DEMITROVICOVA, et al. "Eight-Year Surveillance of Non-Albicans Candida spp. in an Oncology Department Prior to and After Fluconazole Had Been Introduced into Antifungal Prophylaxis." Microbial Drug Resistance 3, no. 3 (1997): 283–87. http://dx.doi.org/10.1089/mdr.1997.3.283.

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10

Choucair, Ali, K. "Quality of life in oncology with emphasis upon neuro-oncology." Frontiers in Bioscience 12, no. 1 (2007): 392. http://dx.doi.org/10.2741/2071.

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Medboua-Benbalagh, Chafiaa, Abdelaziz Touati, Rachida Kermas та ін. "Fecal Carriage of Extended-Spectrum β-Lactamase-ProducingEnterobacteriaceaeStrains Is Associated with Worse Outcome in Patients Hospitalized in the Pediatric Oncology Unit of Beni-Messous Hospital in Algiers, Algeria". Microbial Drug Resistance 23, № 6 (2017): 757–63. http://dx.doi.org/10.1089/mdr.2016.0153.

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Zicklerova, Ivana, Magdalena Uzlikova, and Eva Nohynkova. "Molecular evidence of Pneumocystis jirovecii reinfection in a haemato-oncology patient." Scandinavian Journal of Infectious Diseases 44, no. 9 (2012): 705–7. http://dx.doi.org/10.3109/00365548.2012.677062.

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Touati, Abdelaziz, Melissa Talbi, Assia Mairi та ін. "Fecal Carriage of Extended-Spectrum β-Lactamase and Carbapenemase-Producing Enterobacterales Strains in Patients with Colorectal Cancer in the Oncology Unit of Amizour Hospital, Algeria: A Prospective Cohort Study". Microbial Drug Resistance 26, № 11 (2020): 1383–89. http://dx.doi.org/10.1089/mdr.2019.0350.

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Hampshire, Karly, Lauren Phinney, Elizabeth E. McCarthy, Brian Schwartz, Peter Chin-Hong, and Peter Chin-Hong. "1127. Medical School in the Era of COVID-19: Innovations in Direct Near Peer Teaching of Immunology/Microbiology Content During the Pandemic." Open Forum Infectious Diseases 7, Supplement_1 (2020): S593. http://dx.doi.org/10.1093/ofid/ofaa439.1313.

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Abstract Background Near-peer teaching (NPT) is increasingly utilized in undergraduate medical education. At our institution’s NPT program, teachers are recruited and trained in the final block of their first year, involving simultaneous learning and teaching of Immunology and Microbiology content to classmates. This year, in-person training and teaching was conducted virtually due to COVID19. This study aims to understand how NPT in a newly virtual curriculum impacted student experiences of learning infectious disease content. Methods We conducted one-on-one interviews with student-learners a

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Tuxen, Ida Viller, Lars Jønson, Eric Santoni-Rugiu, Jane Preuss Hasselby, Finn Cilius Nielsen, and Ulrik Lassen. "Personalized oncology: genomic screening in phase 1." APMIS 122, no. 8 (2014): 723–33. http://dx.doi.org/10.1111/apm.12293.

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16

Plainvert, Céline, Magalie Longo, Elise Seringe, et al. "A clone of the emergent Streptococcus pyogenes emm89 clade responsible for a large outbreak in a post-surgery oncology unit in France." Medical Microbiology and Immunology 207, no. 5-6 (2018): 287–96. http://dx.doi.org/10.1007/s00430-018-0546-1.

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Visoná, Kirsten, Fulgencio Baez, Lizeth Taylor, et al. "Impact of Hepatitis B and Hepatitis C Virus Infections in a Hematology-Oncology Unit at a Children's Hospital in Nicaragua, 1997 to 1999." Clinical and Vaccine Immunology 9, no. 3 (2002): 622–26. http://dx.doi.org/10.1128/cdli.9.3.622-626.2002.

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ABSTRACT The risk of acquiring both hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in patients with hematological-oncological disorders has been documented. However, the impact and risk factors for such infections from different geographical areas vary, and the use of both immunological and molecular assays to determine HCV infections has been our approach. Children from a hematology-oncology unit (HOU) in Nicaragua were studied for both HBV and HCV serological markers; studies for the latter used both immunological (anti-HCV) and molecular (HCV RNA) assays. The children from t

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Liassine, Nadia, Jacques Bille, Claus Breer, Reno Frei, JÜRg Wüst, and Raymond Auckenthaler. "In vitro Activity of Cefpirome against Microorganisms Isolated in Haematology, Oncology and Intensive Care Units in Switzerland." Scandinavian Journal of Infectious Diseases 29, no. 6 (1997): 615–21. http://dx.doi.org/10.3109/00365549709035905.

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19

Tinelli, Andrea, William H. Catherino, Antonio R. Gargiulo, et al. "Uterine Fibroids: From Molecular Oncology to Reproduction." BioMed Research International 2018 (September 3, 2018): 1–2. http://dx.doi.org/10.1155/2018/6284875.

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Cesaro, Simone, Mareva Giacchino, Francesca Fioredda, et al. "Guidelines on Vaccinations in Paediatric Haematology and Oncology Patients." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/707691.

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Objective.Vaccinations are the most important tool to prevent infectious diseases. Chemotherapy-induced immune depression may impact the efficacy of vaccinations in children.Patients and Methods. A panel of experts of the supportive care working group of the Italian Association Paediatric Haematology Oncology (AIEOP) addressed this issue by guidelines on vaccinations in paediatric cancer patients. The literature published between 1980 and 2013 was reviewed.Results and Conclusion. During intensive chemotherapy, vaccination turned out to be effective for hepatitis A and B, whilst vaccinations wi

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Argiles, Josep, M. "Targets in clinical oncology: the metabolic environment of the patient." Frontiers in Bioscience 12, no. 8-12 (2007): 3024. http://dx.doi.org/10.2741/2293.

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Chisholm, Jolene, Shashank Bhatt, Amélie Chaboureau, and Sowmya Viswanathan. "Strategy for an abbreviated in-house qualification of a commercially available Rapid Microbiology Method (RMM) for canadian regulatory approval." Cytotherapy 19, no. 12 (2017): 1529–36. http://dx.doi.org/10.1016/j.jcyt.2017.09.004.

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Oh, Hyang Soon, Eui Chong Kim, Myoung Don Oh, and Kang Won Choe. "Outbreak of vancomycin resistant enterococcus in a hematology/oncology unit in a Korean university hospital, and risk factors related to patients, staff, hospital care and facilities." Scandinavian Journal of Infectious Diseases 36, no. 11-12 (2004): 790–94. http://dx.doi.org/10.1080/00365540410021117.

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24

Enquist, Lynn W. "John N. Brady (1952-2009): a Generous Spirit." Journal of Virology 83, no. 14 (2009): 6975–76. http://dx.doi.org/10.1128/jvi.00985-09.

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ABSTRACT John N. Brady, Chief of the Virus Tumor Biology Section of the Laboratory of Cellular Oncology, National Institutes of Health, died of cancer on 27 April 2009. John was a stellar member of the virology community. He was a longtime Journal of Virology reviewer and a member of the editorial board. He will be missed. Fatah Kashanchi of the George Washington University Medical Center has written John's memorial. Fatah worked with John at the NIH and published more than 30 papers with him. Fatah thanks all the people who contributed to John's obituary, including Kuan-Teh Jeang, Lou Laimins

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Burgess, Shane C., and T. Fred Davison. "Identification of the Neoplastically Transformed Cells in Marek's Disease Herpesvirus-Induced Lymphomas: Recognition by the Monoclonal Antibody AV37." Journal of Virology 76, no. 14 (2002): 7276–92. http://dx.doi.org/10.1128/jvi.76.14.7276-7292.2002.

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ABSTRACT Understanding the interactions between herpesviruses and their host cells and also the interactions between neoplastically transformed cells and the host immune system is fundamental to understanding the mechanisms of herpesvirus oncology. However, this has been difficult as no animal models of herpesvirus-induced oncogenesis in the natural host exist in which neoplastically transformed cells are also definitively identified and may be studied in vivo. Marek's disease (MD) herpesvirus (MDV) of poultry, although a recognized natural oncogenic virus causing T-cell lymphomas, is no excep

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Klichko, Vladimir, Nancy Archin, Rupinderjeet Kaur, Ginger Lehrman, and David Margolis. "Hexamethylbisacetamide Remodels the Human Immunodeficiency Virus Type 1 (HIV-1) Promoter and Induces Tat-Independent HIV-1 Expression but Blunts Cell Activation." Journal of Virology 80, no. 9 (2006): 4570–79. http://dx.doi.org/10.1128/jvi.80.9.4570-4579.2006.

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ABSTRACT Hexamethylbisacetamide (HMBA) induces human immunodeficiency virus type 1 (HIV-1) gene expression in latently infected T-cell and monocytoid cell lines. We find that HMBA activation of viral expression is Tat independent but, like Tat, increases the efficiency of elongation of the HIV-1 promoter (long terminal repeat [LTR]) transcripts. Further, exposure to HMBA induces chromatin remodeling at nucleosome 1 (Nuc-1) near the start site of LTR transcription but does so without increasing histone acetylation or altering histone methylation near Nuc-1. Of note, despite enhanced proviral ex

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Lauer, Peter, Bill Hanson, Edward E. Lemmens, et al. "Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains." Infection and Immunity 76, no. 8 (2008): 3742–53. http://dx.doi.org/10.1128/iai.00390-08.

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ABSTRACT Recombinant vaccines derived from the facultative intracellular bacterium Listeria monocytogenes are presently undergoing early-stage clinical evaluation in oncology treatment settings. This effort has been stimulated in part due to preclinical results that illustrate potent activation of innate and adaptive immune effectors by L. monocytogenes vaccines, combined with efficacy in rigorous animal models of malignant and infectious disease. Here, we evaluated the immunologic potency of a panel of isogenic vaccine strains that varied only in prfA. PrfA is an intracellularly activated tra

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Fridman, Wolf H. "Principles of the therapeutic use of monoclonal antibodies in oncology." Comptes Rendus Biologies 329, no. 4 (2006): 255–59. http://dx.doi.org/10.1016/j.crvi.2005.12.009.

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Groner, Bernd L., and Nancy E. Hynes. "Breast Cancer Patients Have Greatly Benefited from the Progress in Molecular Oncology." PLOS Biology 14, no. 9 (2016): e2000314. http://dx.doi.org/10.1371/journal.pbio.2000314.

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Piruzyan, L. A., and A. L. Piruzyan. "The use of defibrillation for the prevention of postoperative metastasizing in oncology." Doklady Biological Sciences 400, no. 1-6 (2005): 8–9. http://dx.doi.org/10.1007/s10630-005-0028-7.

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Ionescu, Sînziana, Octavia-Luciana Madge, Ioana Robu, Eugen Brătucu, and Claudiu Daha. "Surgical Oncology in Romania: An Analysis of Research and Impact Based on Literature Search in PubMed and Web of Science." BioMed Research International 2021 (March 8, 2021): 1–7. http://dx.doi.org/10.1155/2021/5528582.

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Background. With a long tradition and outstanding contributions over time, medical scientific research in Romania has experienced major changes in the last two decades, marked by an increase in scientific publications, originating especially from university centers and fostered by national regulations on publication standards required for professional promotion. This study is aimed at assessing the literature on surgical oncology in Romania, published by Romanian authors in journals indexed in international databases. Materials and Methods. A literature search was performed, focused on surgica

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Sikov, W. M. "Weekly Paclitaxel as a radiation sensitizer for locally advanced gastric and pancreatic cancers The Brown University Oncology Group experience." Frontiers in Bioscience 2, no. 5 (1997): e21-27. http://dx.doi.org/10.2741/a222.

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Ivanova, Anastasia, Bahjat F. Qaqish, and Michael J. Schell. "Continuous Toxicity Monitoring in Phase II Trials in Oncology." Biometrics 61, no. 2 (2005): 540–45. http://dx.doi.org/10.1111/j.1541-0420.2005.00311.x.

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El Orche, Aimen, Casimir Adade Adade, Hafid Mefetah, et al. "Chemometric Analysis of UV-Visible Spectral Fingerprints for the Discrimination and Quantification of Clinical Anthracycline Drug Preparation Used in Oncology." BioMed Research International 2021 (May 6, 2021): 1–8. http://dx.doi.org/10.1155/2021/5580102.

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In clinical treatment, the analytical quality assessment of the delivery of chemotherapeutic preparations is required to guarantee the patient’s safety regarding the dose and most importantly the appropriate anticancer drug. On its own, the development of rapid analytical methods allowing both qualitative and quantitative control of the formulation of prepared solutions could significantly enhance the hospital’s workflow, reducing costs, and potentially providing optimal patient care. UV-visible spectroscopy is a nondestructive, fast, and economical technique for molecular characterization of

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Chang, Alicia H., and Julie Parsonnet. "Role of Bacteria in Oncogenesis." Clinical Microbiology Reviews 23, no. 4 (2010): 837–57. http://dx.doi.org/10.1128/cmr.00012-10.

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SUMMARY Although scientific knowledge in viral oncology has exploded in the 20th century, the role of bacteria as mediators of oncogenesis has been less well elucidated. Understanding bacterial carcinogenesis has become increasingly important as a possible means of cancer prevention. This review summarizes clinical, epidemiological, and experimental evidence as well as possible mechanisms of bacterial induction of or protection from malignancy.

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Stallard, Nigel, and Peter F. Thall. "Decision-Theoretic Designs for Pre-Phase II Screening Trials in Oncology." Biometrics 57, no. 4 (2001): 1089–95. http://dx.doi.org/10.1111/j.0006-341x.2001.01089.x.

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Elgoraish, Amanda, and Ahmed Alnory. "Associated predictor covariates of cervical cancer and impact on survival at Khartoum oncology hospital, Sudan." F1000Research 10 (February 15, 2021): 114. http://dx.doi.org/10.12688/f1000research.43590.1.

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Background: Cervical cancer can be invasive and advanced at diagnosis causing devastating suffering and premature death. Cancer stage at presentation is related to survival evaluation and several factors determine stage. The aim of the study was to examine predictors covariates associated with cervical cancer stage and its impact on patient prognosis and survival. Methods: This retrospective cross-sectional study was carried out at Khartoum oncology hospital, Sudan. Participants were 239 cervical cancer patients diagnosed and treated between 2011-2015. Patients’ pathological and socio-demograp

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Texier, Matthieu, Federico Rotolo, Michel Ducreux, Olivier Bouché, Jean-Pierre Pignon, and Stefan Michiels. "Evaluation of Treatment Effect with Paired Failure Times in a Single-Arm Phase II Trial in Oncology." Computational and Mathematical Methods in Medicine 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/1672176.

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In early phase clinical trials of cytotoxic drugs in oncology, the efficacy is typically evaluated based on the tumor shrinkage. However, this criterion is not always appropriate for more recent cytostatic agents, and alternative endpoints have been proposed. The growth modulation index (GMI), defined as the ratio between the times to progression in two successive treatment lines, has been proposed for a single-arm phase II trials. The treatment effect is evaluated by estimating the rate of patients having a GMI superior to a given threshold. To estimate this rate, we investigated a parametric

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Kwon, KiBeom, David Woolston, Alexandre Hirayama, et al. "643 Autopsy review of chimeric-antigen receptor T cell therapy: a single institution experience." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A680. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0643.

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BackgroundOur institution has treated over 300 patients with chimeric antigen receptor (CAR) T-cell immunotherapy (CAR T-cell therapy) since 2013. Phase I and II trials were primarily based on heavily treated patients with B cell acute lymphoblastic leukemia (B-ALL), aggressive diffuse large B cell lymphoma (DLBCL), and multiple myeloma (MM) who had failed multiple lines of prior chemotherapy and/or hematopoietic stem cell transplantation (HSCT). In these relapsed and/or refractory patients, CAR-T therapy resulted in complete remission in 93% of B-ALL, 60% of DLBCL, and ~80% of MM. Our Patholo

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Thall, Peter F., and Su-Chun Chengt. "Treatment Comparisons Based on Two-Dimensional Safety and Efficacy Alternatives in Oncology Trials." Biometrics 55, no. 3 (1999): 746–53. http://dx.doi.org/10.1111/j.0006-341x.1999.00746.x.

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Kuzan, Aleksandra, and Olga Michel. "Protrusive and retractive structures formed during cell migration." Postępy Higieny i Medycyny Doświadczalnej 72 (May 17, 2018): 392–405. http://dx.doi.org/10.5604/01.3001.0012.0536.

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Cell migration is essential to many physiological processes; however, it is also a cause of cancer metastasis formation and other pathological phenomena. Due to structural and functional variety of cells, a variety of structures formed by the cell membrane, which are designed to initiate or maintain cell movement, are observed. The work describes 12 such structures: lamellipodium, lamellum, filopodium, microspikes, blebs, lobopodium, invadopodium, podosomes, dorsal and peripheral ruffles, pseudopodium and uropodium. We described a characteristics of the structure, mechanism of its formation an

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Franco, Pierfrancesco, Lofti Kochbati, Marco Siano, and Berardino De Bari. "Suggestions for Radiation Oncologists during the COVID-19 Pandemic." BioMed Research International 2020 (May 27, 2020): 1–4. http://dx.doi.org/10.1155/2020/4892382.

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SARS-CoV-2 pandemic and COVID-19 diffusion have recently become an international public health emergency. Cancer patients, as a frail population, are particularly exposed to the risk related to infections. The clinical decision-making process and the organizational workflow of radiotherapy department should be revised in the light of the critical situation. We herein provide practical suggestions derived from the available literature and discussed during an online session held within the e-learning educational program of the European School of Oncology on March 31st 2020.

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Zhou, Dongkai, Bingqiang Gao, Qifan Yang, Yang Kong, and Weilin Wang. "Integrative Analysis of ceRNA Network Reveals Functional lncRNAs in Intrahepatic Cholangiocarcinoma." BioMed Research International 2019 (November 25, 2019): 1–9. http://dx.doi.org/10.1155/2019/2601271.

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Intrahepatic cholangiocarcinoma (ICC) is the second most common lethal liver cancer worldwide. Currently, despite the latest developments in genomics and transcriptomics for ICC in recent years, the molecular pathogenesis promoting ICC remains elusive, especially in regulatory mechanisms of long noncoding RNAs (lncRNAs), which acts as competing endogenous RNA (ceRNA). In order to elucidate the molecular mechanism of functional lncRNA, expression profiles of lncRNAs, microRNAs (miRNAs), and messenger RNAs (mRNAs) were obtained from The Cancer Genome Atlas (TCGA) database and an integrative anal

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Li, Yimei, and Ying Yuan. "PA‐CRM: A continuous reassessment method for pediatric phase I oncology trials with concurrent adult trials." Biometrics 76, no. 4 (2020): 1364–73. http://dx.doi.org/10.1111/biom.13217.

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Sargent, Daniel, Sumithra Mandrekar, and Ann Oberg. "Handbook of Statistics in Clinical Oncology, 2nd edition Edited by Crowley, J. and Ankerst, D. P." Biometrics 62, no. 4 (2006): 1277–78. http://dx.doi.org/10.1111/j.1541-0420.2006.00596_11.x.

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Stanczuk, G. A., E. N. Sibanda, S. A. Tswana та S. Bergstrom. "Polymorphism at the –308-promoter position of the tumor necrosis factor-alpha (TNF-α) gene and cervical cancer". International Journal of Gynecologic Cancer 13, № 2 (2003): 148–53. http://dx.doi.org/10.1136/ijgc-00009577-200303000-00008.

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The purpose of the study was to investigate the hypothesis that the genetically programmed ability to produce low, medium, or high levels of tumor necrosis factor-alpha (TNF-α), as determined by TNF-α promoter polymorphism at position 308, influenced the development of cancer of the uterine cervix. The population was recruited from patients attending gynecological clinics at two teaching hospitals in Harare, Zimbabwe. Laboratory tests were performed in the Departments of Immunology and Medical Microbiology, Medical School, University of Zimbabwe. One hundred and three patients with invasive ca

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Zhu, Haoran, Shaun Blake, Keefe T. Chan, Richard B. Pearson та Jian Kang. "Cystathionineβ-Synthase in Physiology and Cancer". BioMed Research International 2018 (28 червня 2018): 1–11. http://dx.doi.org/10.1155/2018/3205125.

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Cystathionineβ-synthase (CBS) regulates homocysteine metabolism and contributes to hydrogen sulfide (H2S) biosynthesis through which it plays multifunctional roles in the regulation of cellular energetics, redox status, DNA methylation, and protein modification. Inactivating mutations in CBS contribute to the pathogenesis of the autosomal recessive disease CBS-deficient homocystinuria. Recent studies demonstrating that CBS promotes colon and ovarian cancer growth in preclinical models highlight a newly identified oncogenic role for CBS. On the contrary, tumor-suppressive effects of CBS have be

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Qian, Wang, Wang Xiaoyi, and Ye Zi. "Screening and Bioinformatics Analysis of IgA Nephropathy Gene Based on GEO Databases." BioMed Research International 2019 (July 16, 2019): 1–7. http://dx.doi.org/10.1155/2019/8794013.

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Purpose. To identify novel biomarkers of IgA nephropathy (IgAN) through bioinformatics analysis and elucidate the possible molecular mechanism. Methods. The GSE93798 and GSE73953 datasets containing microarray data from IgAN patients and healthy controls were downloaded from the GEO database and analyzed by the GEO2R web tool to obtain different expressed genes (DEGs). Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, protein-protein interaction (PPI), and Biological Networks Gene Oncology tool (BiNGO) were then performed to elucidate the molecular mechani

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Mirabelli, Peppino, and Mariarosaria Incoronato. "Usefulness of Traditional Serum Biomarkers for Management of Breast Cancer Patients." BioMed Research International 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/685641.

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The measurement of serum tumor markers levels in breast cancer (BC) patients is an economic and noninvasive diagnostic assay frequently requested by clinical oncologists to get information about the presence or absence of disease as well as its evolution. Despite their wide use in clinical practice, there is still an intense debate between scientific organizations about the real usefulness for patient monitoring during followup as well as response to therapy evaluation in case of advanced BC. In this review, we want to highlight the current recommendations published by scientific organizations

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Sharma, Arun, Nitin Jain, and Rashmi Sareen. "Nanocarriers for Diagnosis and Targeting of Breast Cancer." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/960821.

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Breast cancer nanotherapeutics is consistently progressing and being used to remove the various limitations of conventional method available for the diagnosis and treatment of breast cancer. Nanoparticles provide an interdisciplinary area for research in imaging, diagnosis, and targeting of breast cancer. With advanced physicochemical properties and better bioavailability, they show prolonged blood circulation with efficient tumor targeting. Passive targeting mechanisms by using leaky vasculature, tumor microenvironment, or direct local application and active targeting approaches using recepto

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