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Journal articles on the topic 'Microbiota imbalance'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Liu, Qihong, Yunfeng Luo, and Xiao Ke. "Interaction between the Gut Microbiota and Intestinal Motility." Evidence-Based Complementary and Alternative Medicine 2022 (November 15, 2022): 1–5. http://dx.doi.org/10.1155/2022/3240573.

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The gut microbiota is the largest symbiotic ecosystem with the host and has been proven to play an important role in maintaining the stability of the intestinal environment. The imbalance of the gut microbiota is caused by the imbalance between the symbiotic microbiota and the pathogenic microbiota. The commensal microbiome regulates intestinal motility, while the pathogenic microbiome causes intestinal motility disorder, resulting in disease development. Intestinal motility is a relatively general term, and its meaning may include intestinal muscle contraction, intestinal wall biomechanics, i

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Wei, Mingbang, Huaizhi Liu, Yu Wang, Mingyang Sun, and Peng Shang. "Mechanisms of Male Reproductive Sterility Triggered by Dysbiosis of Intestinal Microorganisms." Life 14, no. 6 (2024): 694. http://dx.doi.org/10.3390/life14060694.

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Abstract: The intestinal microbiota, comprised of bacteria, archaea, and phages, inhabits the gastrointestinal tract of the organism. Male reproductive sterility is currently a prominent topic in medical research. Increasing research suggests that gut microbiota dysbiosis can result in various reproductive health problems. This article specifically investigates the impact of gut microbiota dysbiosis on male reproductive infertility development. Gut microbiota imbalances can disrupt the immune system and immune cell metabolism, affecting testicular growth and sperm production. This dysfunction

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Origüela, Valentina, and Alvaro Lopez-Zaplana. "Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics." Microorganisms 13, no. 5 (2025): 1084. https://doi.org/10.3390/microorganisms13051084.

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The importance of the microbiome, particularly the gut microbiota and its implications for health, is well established. However, an increasing number of studies further strengthen the link between an imbalanced gut microbiota and a greater predisposition to different diseases. The gut microbiota constitutes a fundamental ecosystem for maintaining human health. Its alteration, known as dysbiosis, is associated with a wide range of conditions, including intestinal, metabolic, immunological, or neurological pathologies, among others. In recent years, there has been a substantial increase in knowl

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Khamrokulovich, Babakulov Sharof. "CHANGES IN THE COMPOSITION OF GUINEA PIG SALIVA DURING MICROBIOTA IMBALANCE." American Journal Of Biomedical Science & Pharmaceutical Innovation 4, no. 12 (2024): 18–21. https://doi.org/10.37547/ajbspi/volume04issue12-04.

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This article investigates the biochemical characteristics of guinea pig saliva under conditions of dysbiosis. Dysbiosis, which represents a disruption of normal microbiota, can significantly impact the health of animals and their physiological processes. In the course of the experiment, key components of saliva, including proteins, carbohydrates, and electrolytes, were analyzed to identify changes associated with microbiota imbalance. The results showed significant deviations in the biochemical composition of guinea pig saliva, indicating potential mechanisms by which dysbiosis affects digesti

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Tîrziu, Andreea-Talida, Monica Susan, Razvan Susan, et al. "From Gut to Eye: Exploring the Role of Microbiome Imbalance in Ocular Diseases." Journal of Clinical Medicine 13, no. 18 (2024): 5611. http://dx.doi.org/10.3390/jcm13185611.

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Background: The gut microbiome plays a crucial role in human health, and recent research has highlighted its potential impact on ocular health through the gut–eye axis. Dysbiosis, or an imbalance in the gut microbiota, has been implicated in various ocular diseases. Methods: A comprehensive literature search was conducted using relevant keywords in major electronic databases, prioritizing recent peer-reviewed articles published in English. Results: The gut microbiota influences ocular health through immune modulation, maintenance of the blood–retinal barrier, and production of beneficial metab

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Fernandes, Camila, Mahara Coelho Crisostomo Miranda, Cássia Rodrigues Roque, et al. "Is There an Interplay between Environmental Factors, Microbiota Imbalance, and Cancer Chemotherapy-Associated Intestinal Mucositis?" Pharmaceuticals 17, no. 8 (2024): 1020. http://dx.doi.org/10.3390/ph17081020.

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Interindividual variation in drug efficacy and toxicity is a significant problem, potentially leading to adverse clinical and economic public health outcomes. While pharmacogenetics and pharmacogenomics have long been considered the primary causes of such heterogeneous responses, pharmacomicrobiomics has recently gained attention. The microbiome, a community of microorganisms living in or on the human body, is a critical determinant of drug response and toxicity. Factors such as diet, lifestyle, exposure to xenobiotics, antibiotics use, illness, and genetics can influence the composition of th

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Gagnière, Johan. "Gut microbiota imbalance and colorectal cancer." World Journal of Gastroenterology 22, no. 2 (2016): 501. http://dx.doi.org/10.3748/wjg.v22.i2.501.

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Pires, Lara, Ana M. González-Paramás, Sandrina A. Heleno, and Ricardo C. Calhelha. "Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators." Antibiotics 13, no. 8 (2024): 720. http://dx.doi.org/10.3390/antibiotics13080720.

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The gut microbiota establishes a mutually beneficial relationship with the host starting from birth, impacting diverse metabolic and immunological processes. Dysbiosis, characterized by an imbalance of microorganisms, is linked to numerous medical conditions, including gastrointestinal disorders, cardiovascular diseases, and autoimmune disorders. This imbalance promotes the proliferation of toxin-producing bacteria, disrupts the host’s equilibrium, and initiates inflammation. Genetic factors, dietary choices, and drug use can modify the gut microbiota. However, there is optimism. Several thera

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Volynets, Galina V., A. I. Khavkin, T. A. Skvortsova, A. V. Nikitin, and V. V. Matkash. "DISEASES OF THE LIVER AND INTESTINAL MICROBIOME." Russian Pediatric Journal 21, no. 6 (2019): 366–77. http://dx.doi.org/10.18821/1560-9561-2018-21-6-366-377.

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The review presents data on the effect of the intestinal microbiota on the regulation of the synthesis and metabolism of bile acids. Violations of the bile acid pool have been shown to be accompanied by an imbalance of the intestinal microbiota, which can determine the dynamics of the formation of cholestatic liver diseases and their progression up to cirrhosis of the liver. Impaired bile acid synthesis is often caused by an imbalance in the intestinal microbiome. Changes in the complex connections of the intestinal microbiome and the metabolism of bile acids influence the formation of liver a

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Izmailovich, M. R., O. Y. Dedova, B. S. Koshkarbayeva, et al. "Liver Dysfunction and Microbiome Imbalance: Their Role in the Development of Allergic Reactions." Juvenis Scientia 11, no. 2 (2025): 21–32. https://doi.org/10.32415/jscientia_2025_11_2_21-32.

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Over the past decades, there has been a significant increase in the prevalence of allergic diseases, attributed to multiple factors, including liver dysfunction and gut microbiome imbalance. The liver plays a central role in allergen detoxification, immune response regulation, metabolism of inflammatory mediators, and maintenance of immune tolerance. Impairment of liver function can lead to the accumulation of toxins and metabolic byproducts, contributing to hypersensitivity and inflammatory processes. On the other hand, the gut microbiota actively participates in immune homeostasis and the de

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Karla, Yazmin Gámiz Villareal, Rodriguez Santillanes Alejandra, and Lazalde Brissia. "Microbiota and microbiome in relation to diabetes and obesity." GSC Advanced Research and Reviews 19, no. 3 (2024): 176–81. https://doi.org/10.5281/zenodo.13622346.

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Millions of microorganisms compose the human gut microbiota, essential for maintaining metabolic health. Recent research has shown that the gut microbiome of people with obesity and diabetes changes significantly in composition and functionality. These changes are characterized by a decrease in diversity and an overrepresentation of certain microbial agents that have detrimental metabolic effects. Dysbiosis, an imbalance in the gut microbiota, contributes to the development and progression of metabolic disorders in several ways, including increased intestinal permeability, inflammation, and al

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Mocanu, Adriana, Roxana Alexandra Bogos, Tudor Ilie Lazaruc, et al. "Exploring a Complex Interplay: Kidney–Gut Axis in Pediatric Chronic Kidney Disease." Nutrients 15, no. 16 (2023): 3609. http://dx.doi.org/10.3390/nu15163609.

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The human intestinal microbiota is a highly intricate structure with a crucial role in promoting health and preventing disease. It consists of diverse microbial communities that inhabit the gut and contribute to essential functions such as food digestion, nutrient synthesis, and immune system development. The composition and function of the gut microbiota are influenced by a variety of factors, including diet, host genetics, and environmental features. In pediatric patients, the gut microbiota is particularly dynamic and vulnerable to disruption from endogenous and exogenous factors. Recent re

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De Almeida, Carolina Vieira, Emiliano Antiga, and Matteo Lulli. "Oral and Topical Probiotics and Postbiotics in Skincare and Dermatological Therapy: A Concise Review." Microorganisms 11, no. 6 (2023): 1420. http://dx.doi.org/10.3390/microorganisms11061420.

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The skin microbiota is a pivotal contributor to the maintenance of skin homeostasis by protecting it from harmful pathogens and regulating the immune system. An imbalance in the skin microbiota can lead to pathological conditions such as eczema, psoriasis, and acne. The balance of the skin microbiota components can be disrupted by different elements and dynamics such as changes in pH levels, exposure to environmental toxins, and the use of certain skincare products. Some research suggests that certain probiotic strains and their metabolites (postbiotics) may provide benefits such as improving

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Kaibysheva, V. O., M. E. Zharova, K. Yu Filimendikova, and E. L. Nikonov. "Diseases Associated with Disturbed Intestinal Microbiota." Doctor.Ru 20, no. 4 (2021): 40–45. http://dx.doi.org/10.31550/1727-2378-2021-20-4-40-45.

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Objective of the Review: To discuss changes in intestinal microbiota in various diseases. Key Points. Microbial intestinal imbalance plays an important role in pathogenesis and/or progression of a number of diseases, namely of Clostridium difficile-associated disorders, intestinal inflammations, obesity, colorectal cancer, autistic disorders and other. Moreover, therapies involving faecal microbiota transplantation, use of pro- and prebiotics, metabiotics proved efficient in management of some of the above disorders. Conclusion. So far, some mechanisms have been explored which explain possible

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Lyu, Yi, Lei Wu, Fang Wang, Xinchun Shen, and Dingbo Lin. "Carotenoid supplementation and retinoic acid in immunoglobulin A regulation of the gut microbiota dysbiosis." Experimental Biology and Medicine 243, no. 7 (2018): 613–20. http://dx.doi.org/10.1177/1535370218763760.

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Dysbiosis, a broad spectrum of imbalance of the gut microbiota, may progress to microbiota dysfunction. Dysbiosis is linked to some human diseases, such as inflammation-related disorders and metabolic syndromes. However, the underlying mechanisms of the pathogenesis of dysbiosis remain elusive. Recent findings suggest that the microbiome and gut immune responses, like immunoglobulin A production, play critical roles in the gut homeostasis and function, and the progression of dysbiosis. In the past two decades, much progress has been made in better understanding of production of immunoglobulin

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CÎNPEANU, Oana Cristina, Victoria RUS, and Monica TARCEA. "Insight about Colonic Microbiota Imbalance and Obesity." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Food Science and Technology 76, no. 1 (2019): 19. http://dx.doi.org/10.15835/buasvmcn-fst:2019.0007.

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Since the 1990s, nutritionists have concluded that poor food hygiene, as well as environmental and food pollution, are the cause of the major serious diseases affecting humanity: overweight and obesity, which induce persistent systemic pro-inflammatory status, and hence all complications metabolic disorders, cancers, joint diseases, skin disorders, psychological disorders. The human body hosts a large number of microbes, including bacterial, fungal and protozoal microorganisms, which together constitute our microbe. Dysbiosis, generated by a sedentary lifestyle, consuming highly industrialized

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Elamin, Yousef Mohammed, Asma Saad Yahya Alahmari, Afnan Saeed H. Mgbel, et al. "Association Between Vaginal Microbiota and Infertility: A Systematic Review." Saudi Medical Horizons Journal 5, no. 2 (2025): 138–46. https://doi.org/10.54293/smhj.v5i2.150.

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The aim of this systematic review was to synthesize the available evidence on the relationship between vaginal microbiota and infertility, highlighting key microbial factors and their impact on reproductive outcomes. A comprehensive search of four databases identified 1,216 relevant publications. After duplicate removal using Rayyan QCRI and relevance screening, 605 full-text articles were reviewed, with nine studies ultimately meeting inclusion criteria. The included nine studies involving 1,768 women with vaginal infections. A significant microbial imbalance was observed in infertile women c

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Karla Yazmin Gámiz Villareal, Alejandra Rodriguez Santillanes, and Brissia Lazalde. "Microbiota and microbiome in relation to diabetes and obesity." GSC Advanced Research and Reviews 19, no. 3 (2024): 176–81. http://dx.doi.org/10.30574/gscarr.2024.19.3.0224.

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Millions of microorganisms compose the human gut microbiota, essential for maintaining metabolic health. Recent research has shown that the gut microbiome of people with obesity and diabetes changes significantly in composition and functionality. These changes are characterized by a decrease in diversity and an overrepresentation of certain microbial agents that have detrimental metabolic effects. Dysbiosis, an imbalance in the gut microbiota, contributes to the development and progression of metabolic disorders in several ways, including increased intestinal permeability, inflammation, and al

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Cristofori, Fernanda, Flavia Indrio, Vito Miniello, Maria De Angelis, and Ruggiero Francavilla. "Probiotics in Celiac Disease." Nutrients 10, no. 12 (2018): 1824. http://dx.doi.org/10.3390/nu10121824.

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Recently, the interest in the human microbiome and its interplay with the host has exploded and provided new insights on its role in conferring host protection and regulating host physiology, including the correct development of immunity. However, in the presence of microbial imbalance and particular genetic settings, the microbiome may contribute to the dysfunction of host metabolism and physiology, leading to pathogenesis and/or the progression of several diseases. Celiac disease (CD) is a chronic autoimmune enteropathy triggered by dietary gluten exposure in genetically predisposed individu

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Zhang, Xintong, Xiangyu Wang, Hong Zhao, Risheng Cao, Yini Dang, and Binbin Yu. "Imbalance of Microbacterial Diversity Is Associated with Functional Prognosis of Stroke." Neural Plasticity 2023 (May 8, 2023): 1–13. http://dx.doi.org/10.1155/2023/6297653.

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Objectives. There is mounting evidence to suggest that the pathophysiology of stroke is greatly influenced by the microbiota of the gut and its metabolites, in particular short-chain fatty acids (SCFAs). The primary purpose of the study was to evaluate whether the levels of SCFAs and the gut microbiota are altered in poststroke patients and to examine the relationship between these alterations and the physical condition, intestinal health, pain, or nutritional status of patients. Methods. Twenty stroke patients and twenty healthy controls were enrolled in the current study, and their demograph

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Duran Gonzalez, E., J. A. Ramirez Tejero, A. Martínez Lara, et al. "AB1379 MICROBIOTA AND MITOCHONDRIAL IMBALANCE IN FIBROMYALGIA: A PILOT STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1919.1–1919. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2084.

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BackgroundFibromyalgia (FM) is a widespread chronic disease characterized by chronic pain and fatigue that has a strong impact on the quality of life of patients, who represent the 6% of the world population. There is no molecular analysis FM condition, being currently diagnosed through clinical self-questionnaires. Since FM patients present a strong lack of energy and several gastrointestinal disturbances, the relationship between the microbiota-mitochondrial axis could be a relevant mechanism [1]. The intestinal microbiota has a great impact on health and energy balances. When the distributi

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Zblewski, Jakub, Bartosz Kozakiewicz, Krzysztof Dalke, and Aleksandra Maria Górna. "The role of probiotics in modulating the microbiota of the nose and paranasal sinuses and reducing chronic inflammation of the paranasal sinuses." Polski Przegląd Otorynolaryngologiczny 14, no. 1 (2025): 1–6. https://doi.org/10.5604/01.3001.0054.9412.

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<b>Introduction:</b> The microbiota of the nose and paranasal sinuses plays a crucial role in maintaining the proper function of the mucous membrane of the upper respiratory tract. It consists of diverse bacteria, viruses, fungi, and other microorganisms. Dysbiosis, i.e. imbalance in the microbiota, can lead to diseases such as chronic rhinosinusitis (CRS). Modern techniques of genetic analysis allow a better understanding of the microbiota's impact on the human immune system. <br><br><b>Aim:</b> This review aims to analyze current research on the role of mi

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Jastrząb, Rafał, Damian Graczyk, and Pawel Siedlecki. "Molecular and Cellular Mechanisms Influenced by Postbiotics." International Journal of Molecular Sciences 22, no. 24 (2021): 13475. http://dx.doi.org/10.3390/ijms222413475.

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In recent years, commensal bacteria colonizing the human body have been recognized as important determinants of health and multiple pathologic conditions. Among the most extensively studied commensal bacteria are the gut microbiota, which perform a plethora of functions, including the synthesis of bioactive products, metabolism of dietary compounds, and immunomodulation, both through attenuation and immunostimulation. An imbalance in the microbiota population, i.e., dysbiosis, has been linked to many human pathologies, including various cancer types and neurodegenerative diseases. Targeting gu

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Sanat Mahendra Dhoke and Mishthi Prajapati. "The gut-heart connection: how the microbiome influences cardiovascular health." International Journal of Biological and Pharmaceutical Sciences Archive 9, no. 2 (2025): 001–8. https://doi.org/10.53771/ijbpsa.2025.9.2.0034.

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The gut-heart connection has emerged as a significant area of research, revealing how gut microbiota influences cardiovascular disease (CVD) pathophysiology. The gut microbiota has a significant impact on cardiovascular health through its involvement in endothelial function, systemic inflammation, cholesterol metabolism, and metabolic balance. Atherosclerosis, hypertension, myocardial infarction, and heart failure have all been linked to dysbiosis, an imbalance in the makeup of microorganisms. Important metabolites produced by microorganisms have a direct effect on vascular integrity, thrombos

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Amarachukwu, Bernaldine Isiaka, Nonyelum Anakwenze Vivian, Henry Uzoka Ugonna, et al. "Exploring the role of gut microbiota in human health." GSC Biological and Pharmaceutical Sciences 27, no. 1 (2024): 051–59. https://doi.org/10.5281/zenodo.11956198.

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The study explores the intricate relationship between the human gut microbiota and health. It analyzes the gut microbiota’s roles in digestion, metabolism, immune responses, and overall well-being. The review discusses the composition and diversity of gut microbial communities, emphasizing their symbiotic relationship with the host. It also examines how gut dysbiosis, or microbial imbalance, relates to health conditions like inflammatory bowel diseases and metabolic disorders. The review highlights research methodologies like metagenomics and metabolomics that deepen our understanding of

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Jovandaric, Miljana Z., Stefan Dugalic, Sandra Babic, et al. "Programming Factors of Neonatal Intestinal Dysbiosis as a Cause of Disease." International Journal of Molecular Sciences 24, no. 6 (2023): 5723. http://dx.doi.org/10.3390/ijms24065723.

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The intestinal microbiota consists of trillions of bacteria, viruses, and fungi that achieve a perfect symbiosis with the host. They perform immunological, metabolic, and endocrine functions in the body. The microbiota is formed intrauterine. Dysbiosis is a microbiome disorder characterized by an imbalance in the composition of the microbiota, as well as changes in their functional and metabolic activities. The causes of dysbiosis include improper nutrition in pregnant women, hormone therapy, the use of drugs, especially antibiotics, and a lack of exposure to the mother’s vaginal microbiota du

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Rajashree, Thakre* Shantanu Rewatkar Yadnyesha Dahake Dr. Vaibhav Uplanchiwar. "Gut Microbiome and Its Role In Autoimmune Arthritis." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 286–303. https://doi.org/10.5281/zenodo.14982871.

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The gut microbiome, a diverse community of microorganisms, plays a crucial role in immune regulation and the development of autoimmune diseases, including autoimmune arthritis (AA). Dysbiosis, or microbial imbalance, has been linked to the onset and progression of conditions like rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Alterations in the gut microbiota composition can lead to immune system dysfunction, promoting inflammation and joint damage. In autoimmune arthritis, dysbiosis can result in increased production of pro-inflammatory cytokines and autoantibodies, contributing to

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Melnitskaia, A. A., L. V. Matchekhina, A. K. Ilyushchenko, and I. D. Strazhesko. "The gut microbiome as a central player in aging: mechanisms and health outcomes." Problems of Geroscience, no. 3 (September 20, 2024): 154–60. http://dx.doi.org/10.37586/2949-4745-3-2024-154-160.

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The article explores the mechanisms by which the gut microbiome influences human aging and associated diseases. The authors examine age-related changes in the composition of the microbiota and their effects on inflammation, immune response, and intestinal barrier permeability. Special attention is given to the pathogenic interactions between the gut microbiota and the development of cardiovascular, metabolic, and neurodegenerative diseases. The role of microbiome imbalance, known as dysbiosis, is highlighted as one of the key mechanisms accelerating the aging process. The review provides a com

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Cheng, Hongyu, Xiong Guan, Dekun Chen, and Wentao Ma. "The Th17/Treg Cell Balance: A Gut Microbiota-Modulated Story." Microorganisms 7, no. 12 (2019): 583. http://dx.doi.org/10.3390/microorganisms7120583.

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The intestinal tract of vertebrates is normally colonized with a remarkable number of commensal microorganisms that are collectively referred to as gut microbiota. Gut microbiota has been demonstrated to interact with immune cells and to modulate specific signaling pathways involving both innate and adaptive immune processes. Accumulated evidence suggests that the imbalance of Th17 and Treg cells is associated with the development of many diseases. Herein, we emphatically present recent findings to show how specific gut microbiota organisms and metabolites shape the balance of Th17 and Treg ce

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Zhen, Junai, Xueli Yuan, Liping Tao, et al. "Intestinal Ecology Changes in Diarrheic Père David’s Deer Revealed by Gut Microbiota and Fecal Metabolites Analysis." Animals 12, no. 23 (2022): 3366. http://dx.doi.org/10.3390/ani12233366.

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Diarrhea is one of the most common diseases affecting the health of Père David’s deer (Elaphurus davidianus). It is believed that an imbalanced intestinal ecology contributes to the etiology of the condition. However, little is known about how the intestinal ecology changes in these diarrheic animals. In this study, 16S rRNA gene sequencing and ultra-high performance liquid chromatography combined with tandem mass spectrometry (UPLC-MS/MS) were used to investigate the gut microbiota and fecal metabolites in five Père David’s deer with diarrhea. The results showed that when compared with health

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Chilimoniuk, Zuzanna, Dominik Dudziński, Aleksandra Borkowska, et al. "Correlation between gut microbiota dysbiosis and colorectal cancer: review." Quality in Sport 22 (September 18, 2024): 54326. http://dx.doi.org/10.12775/qs.2024.22.54326.

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Introduction and Purpose: The human gut microbiota, comprising a diverse consortium of approximately 100 trillion microorganisms, is integral to maintaining health and modulating disease processes. Its development begins at birth, influenced by maternal microbiota and environmental factors. Dysbiosis, defined as an imbalance in the gut microbial composition, has been implicated in a range of gastrointestinal pathologies, including colorectal cancer (CRC). This review endeavors to elucidate the relationship between gut microbiota and CRC, examining the impact of specific bacterial taxa on the p

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Saran, Aditya B., and Aditi B. Saran. "The role of gut microbiota in modulating immune responses: a systematic review on implications for autoimmune diseases." International Journal of Research in Medical Sciences 13, no. 6 (2025): 2588–97. https://doi.org/10.18203/2320-6012.ijrms20251651.

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The gut microbiota plays a crucial role in immune regulation, influencing innate and adaptive immunity. Dysbiosis an imbalance in microbial composition has been linked to autoimmune diseases such as rheumatoid arthritis (RA), type 1 diabetes (T1D), multiple sclerosis (MS), inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE). This review analyses sixteen studies, highlighting common dysbiosis patterns, including decreased short-chain fatty acid (SCFA)-producing bacteria (Faecalibacterium prausnitzii, Bifidobacterium) and increased pro-inflammatory bacteria (Prevotella copri,

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Leblhuber, Friedrich, Daniela Ehrlich, Kostja Steiner, et al. "The Immunopathogenesis of Alzheimer’s Disease Is Related to the Composition of Gut Microbiota." Nutrients 13, no. 2 (2021): 361. http://dx.doi.org/10.3390/nu13020361.

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The microbiota–gut–brain axis plays an important role in the development of neurodegenerative diseases. Commensal and pathogenic enteric bacteria can influence brain and immune system function by the production of lipopolysaccharides and amyloid. Dysbiosis of the intestinal microbiome induces local and consecutively systemic immune-mediated inflammation. Proinflammatory cytokines then trigger neuroinflammation and finally neurodegeneration. Immune-mediated oxidative stress can lead to a deficiency of vitamins and essential micronutrients. Furthermore, the wrong composition of gut microbiota mi

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Maurya, Ayushi, Sankarasubramanian Vidyameenakshi, and Neerja Masih. "The Role of Gut Microbioma in Human Health: Exploring the Impact on Metabolism, Immunity, and Neurological Disorders." International Journal for Research in Applied Science and Engineering Technology 12, no. 10 (2024): 1014–22. http://dx.doi.org/10.22214/ijraset.2024.64782.

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Abstract: The human microbiota has been progressively accepted for its role in sustaining overall health and well-being. The gut microflora vigorously communicates with the host metabolic system that exert influence on the progression, maturation, immune cells development and immune homeostasis maintenance. For the proper functioning of the immune system a diversified and steady gut microflora is needed, while “Dysbiosis” or an imbalance in the gut microbioma will lead to autoimmune and inflammatory diseases. The gut microbiota provides shape to our immune response and contribute to host prote

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Kharchenko, Yu V., H. I. Titov, D. H. Kryzhanovskyi, et al. "Stress and the Gut-Brain Axis." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 7, no. 4 (2022): 137–46. http://dx.doi.org/10.26693/jmbs07.04.137.

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The purpose of the review was to study the effects of stress on the gut microbiota. Results and discussion. The gut microbiota forms a complex microbial community that has a significant impact on human health. The composition of the microbiota varies from person to person, and it changes throughout life. It is known that the microbiome can be altered due to diet, various processes, such as inflammation and/or stress. Like all other areas of medicine, microbiology is constantly growing. The gut microbiota lives in a symbiotic relationship with the human host. It is now believed to interact with

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Shin, Yoonhwa, Sunhee Han, Juhui Kwon, et al. "Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease." Nutrients 15, no. 20 (2023): 4466. http://dx.doi.org/10.3390/nu15204466.

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The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles in a variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation of dietary fiber. Certain microbes in the gut are responsible for producing SCFAs such as acetate, propionate and butyrate. An imbalance in gut microbiome diversity can lead to metabolic disorders and inflammation-related diseases. Changes in SCFA levels and associated microbiota were observed in IBD, suggesting an association between SCFAs and disease. The gut microbiota and SCF

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Cheemala, Seema Charitha, Saif Syed, Ruqiya Bibi, et al. "Unraveling the Gut Microbiota: Key Insights into its Role in Gastrointestinal and Cardiovascular Health." Journal of Advances in Medicine and Medical Research 36, no. 7 (2024): 34–47. http://dx.doi.org/10.9734/jammr/2024/v36i75483.

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The human gastrointestinal (GI) tract harbors a diverse and dynamic community of microorganisms known as the gut microbiome, which plays a fundamental role in maintaining gastrointestinal (GI) and cardiovascular health. It explores the intricate interplay between the gut microbiota, GI health, and cardiovascular diseases (CVDs). It discusses the essential roles of the gut microbiome in energy metabolism, nutrient absorption, immune regulation, and gut barrier integrity. Dysbiosis, characterized by an imbalance in gut microbiota composition, has been linked to various GI conditions, including i

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Acevedo-Román, Andy, Natalia Pagán-Zayas, Liz I. Velázquez-Rivera, Aryanne C. Torres-Ventura, and Filipa Godoy-Vitorino. "Insights into Gut Dysbiosis: Inflammatory Diseases, Obesity, and Restoration Approaches." International Journal of Molecular Sciences 25, no. 17 (2024): 9715. http://dx.doi.org/10.3390/ijms25179715.

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The gut microbiota is one of the most critical factors in human health. It involves numerous physiological processes impacting host health, mainly via immune system modulation. A balanced microbiome contributes to the gut’s barrier function, preventing the invasion of pathogens and maintaining the integrity of the gut lining. Dysbiosis, or an imbalance in the gut microbiome’s composition and function, disrupts essential processes and contributes to various diseases. This narrative review summarizes key findings related to the gut microbiota in modern multifactorial inflammatory conditions such

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Almonte, Andrew A., and Laurence Zitvogel. "Gut reactions: harnessing microbial metabolism to fuel next-generation cancer immunotherapy." Journal for ImmunoTherapy of Cancer 13, no. 4 (2025): e011540. https://doi.org/10.1136/jitc-2025-011540.

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Immunotherapies, including immune checkpoint inhibitors and chimeric antigen receptor-T cell therapies, depend heavily on a healthy and diverse gut microbiome for optimal efficacy. Dysbiosis, or an imbalance in gut microbial composition and function, can diminish immunotherapy responses by altering immune cell trafficking and metabolic output. Key microbial metabolites such as short-chain fatty acids and modified bile acids shape host immunity and influence T-cell function, while their disruption can foster an immunosuppressive microenvironment. Emerging strategies to restore a balanced microb

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Gupta, PD. "The Human Vaginal Microbiota: Boon or Bane." Obstetrics Gynecology and Reproductive Sciences 5, no. 1 (2021): 01–03. http://dx.doi.org/10.31579/2578-8965/057.

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We are soaked in microbiota, both, externally and internally. The balance between harmful and beneficial keeps us healthy, however even slight imbalance in their ratio may make cause of ill health. Many of the species of Lactobacillus keeps the vagina healthy; even some species of Lactobacillus are troublesome to the vagina. Other pathogenic bacteria and fungus cause many diseases. Lactobacillus spp prevents harmful bacteria to infect the vagina; nevertheless their population varies due to various factors mentioned in the text. Because of this the woman suffers even with infertility, abortions

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Chen, Yijing, Lihua Fang, Shuo Chen, et al. "Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer’s Disease." BioMed Research International 2020 (May 27, 2020): 1–15. http://dx.doi.org/10.1155/2020/8456596.

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Emerging evidence suggests that the gut microbiome actively regulates cognitive functions and that gut microbiome imbalance is associated with Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder. However, the changes in gut microbiome composition in AD and their association with disease pathology, especially in the early stages, are unclear. Here, we compared the profiles of gut microbiota between APP/PS1 transgenic mice (an AD mouse model) and their wild-type littermates at different ages by amplicon-based sequencing of 16S ribosomal RNA genes. Microbiota composition start

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Kalogeropoulos, Dimitrios, Konstantinos Katsikatsos, Konstantinos Dallas, et al. "Role of intestinal microbiome in the pathogenesis of age-related macular degeneration." Medical Hypothesis, Discovery & Innovation in Optometry 1, no. 1 (2020): 29–36. http://dx.doi.org/10.51329/mehdioptometry105.

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Background: The microbiome is strongly linked to many extra-intestinal disorders. Gut commensal microbiota, in particular, plays an active role in human immune and intestinal homeostasis. Complex interactions of the microbiota with host genetics and other underlying factors lead to intestinal dysbiosis, which is thought to be linked to ocular inflammatory diseases. Thus, the aim of this review is to analyze the role of intestinal microbiome in age-related macular degeneration (AMD). Methods: A thorough literature search was performed using PubMed/MEDLINE, limited to English language publ

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Moloney, G. M., M. F. Viola, A. E. Hoban, T. G. Dinan, and J. F. Cryan. "Faecal microRNAs: indicators of imbalance at the host-microbe interface?" Beneficial Microbes 9, no. 2 (2018): 175–83. http://dx.doi.org/10.3920/bm2017.0013.

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The enteric microbiota is characterised by a balance and composition that is unique to the host. It is important to understand the mechanisms through which the host can maintain the composition of the gut microbiota. MicroRNAs (miRNA) are implicated in intercellular communication and have been isolated from bodily fluids including stool. Recent findings suggest that miRNA produced by the host’s intestinal epithelial cells (IECs) participate in shaping the microbiota. To investigate whether miRNA expression was influenced by the gut microbiota we measured the expression of miRNAs expressed by i

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Odun-Ayo, Frederick, and Lalini Reddy. "Gastrointestinal Microbiota Dysbiosis Associated with SARS-CoV-2 Infection in Colorectal Cancer: The Implication of Probiotics." Gastroenterology Insights 13, no. 1 (2022): 35–59. http://dx.doi.org/10.3390/gastroent13010006.

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The complexity of coronavirus disease 2019 (COVID-19)’s pathophysiology is such that microbial dysbiosis in the lung and gastrointestinal (GI) microbiota may be involved in its pathogenic process. GI microbiota dysbiosis has been associated with respiratory disorders, including COVID-19, as well as sporadic colorectal cancer (CRC) through imbalanced microbiota and compromised immune response. It is pertinent to understand the possible role of probiotics in stabilizing the microbial environment and maintaining the integrity of the respiratory and GI tracts in SARS-CoV-2 induced dysbiosis and co

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Pechkurov, Dmitrii V., Olesya N. Zaynullina, Alena A. Tyazheva, and Artem V. Lyamin. "NEW APPROACH TO ASSESSMENT AND CORRECTION OF INTESTINAL MICROBIOME IMBALANCE IN CHILDREN WITH ATOPIC DERMATITIS." Science and Innovations in Medicine 4, no. 1 (2019): 53–57. http://dx.doi.org/10.35693/2500-1388-2019-4-1-53-57.

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Objectives - to study intestinal microbiota species for differentiated approach to treatment of atopic dermatitis (AD) in children. Material and methods. The study included 60 children, 34 girls and 26 boys aged from 3 to 12 years, with AD and concurrent intestinal dysbiosis. The experimental group consisted of 30 children assigned to differentiated correction of intestinal microbiome imbalance in addition to the standard therapy. Correction mode depended on the results of microbiological fecal examination of microbiota species using the mass spectrometry. The control group of 30 children rece

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Jakubiak, Anna, Łukasz Karaban, Michał Borawski, et al. "Dysbiosis and Schizophrenia: A Review of Current Evidence on the Gut–Brain Axis and Probiotic Interventions." Quality in Sport 41 (May 12, 2025): 60353. https://doi.org/10.12775/qs.2025.41.60353.

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Introdution: Schizophrenia is a complex mental disorder influenced by both genetic and environmental factors. Recent research has highlighted the potential role of the gut microbiota in mental health, including schizophrenia. Disruptions in gut microbiota composition, known as dysbiosis, may affect the central nervous system through immune modulation, neuroinflammation, neurotransmitter imbalance, and increased intestinal permeability. Notably, studies have shown associations between dysbiosis and the severity of psychotic symptoms as well as treatment response. Some evidence also suggests tha

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Sun, Quancheng, Zhan Cui, Jinbi Li, et al. "Brazilin-rich extract from Sappan wood attenuates neuroinflammation through the restoration of the gut microbiota: improving cognitive function in mice with age-related Alzheimer’s disease." Aging Advances 1, no. 2 (2024): 92–104. https://doi.org/10.4103/agingadv.agingadv-d-24-00017.

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Alzheimer’s disease is an age-related neurodegenerative disorder characterized by amyloid-β accumulation, which leads to memory impairment, neuroinflammation, and imbalance in the gut microbiota. Targeting neuroinflammation and correcting the imbalance in the gut microbiota may be promising strategies for treating age-related Alzheimer’s disease. Sappan wood, a traditional Chinese medicine known for its neuroprotective and anti-inflammatory properties, has not been extensively studied for its effects on cognitive function in age-related Alzheimer’s disease and neuroinflammation. In this study,

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Kimia, Moiniafshari, kalantari Farshad, and Behzadi Nezhad Hafez. "Nutrition Can Modify Gut-Brain Axis and Medication Induced Metabolic Disorders in Autism Spectrum Disorder- A Hypothesis." International Journal Of Pharmaceutical And Bio-Medical Science 02, no. 09 (2022): 373–75. https://doi.org/10.5281/zenodo.7116032.

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Autism Spectrum Disorder (ASD), is a neurodevelopmental disorder which is accompanied by several health-related challenges. Nutritional and gastrointestinal problems are common among individuals with ASD. Gut microbiota imbalance may be a reason of nutritional problems including food selectivity and restricted dietary intake. Nutritional problems and gut microbiota imbalance can increase behavioral symptoms which may increase the possibility and necessity for medication. It has been suggested that some medications, may increase the risk of metabolic impairments including glucose homeostasis ab

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Chen, Zhaojie, and Fan Zhang. "The Role of Gut Microbiota in Personalized Medicine: Implications for Disease Prevention and Treatment." Journal of Neonatal Surgery 14, no. 10S (2025): 723–27. https://doi.org/10.52783/jns.v14.2913.

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The human gut microbiota is an intricate and diverse ecosystem comprising trillions of microorganisms, including bacteria, viruses, fungi, and archaea. It plays a fundamental role in maintaining overall health by influencing digestion, immune system regulation, and metabolic homeostasis. Recent advancements in microbiome research have enabled the development of personalized medicine strategies that leverage an individual’s unique microbial composition to tailor disease prevention and treatment approaches. Studies have demonstrated that dysbiosis, or an imbalance in the gut microbiota, is assoc

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Dai, Zhujiang, Jihong Fu, Xiang Peng, Dong Tang, and Jinglue Song. "Intestinal Microbiota: The Driving Force behind Advances in Cancer Immunotherapy." Cancers 14, no. 19 (2022): 4796. http://dx.doi.org/10.3390/cancers14194796.

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In recent years, cancer immunotherapy has become a breakthrough method to solve solid tumors. It uses immune checkpoint inhibitors to interfere with tumor immune escape to coordinate anti-tumor therapy. However, immunotherapy has an individualized response rate. Moreover, immune-related adverse events and drug resistance are still urgent issues that need to be resolved, which may be attributed to the immune imbalance caused by immune checkpoint inhibitors. Microbiome research has fully revealed the metabolic-immune interaction relationship between the microbiome and the host. Surprisingly, seq

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