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Journal articles on the topic 'Microdomain compartmentalization'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Sobolczyk, Marta, and Tomasz Boczek. "ROLE OF MEMBRANE MICRODOMAIN COMPARTMENTALIZATION IN GABA-MEDIATED SIGNAL TRANSDUCTION." IBRO Neuroscience Reports 15 (October 2023): S259. http://dx.doi.org/10.1016/j.ibneur.2023.08.443.

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2

Watson, Robert T., Satoshi Shigematsu, Shian-Huey Chiang, et al. "Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation." Journal of Cell Biology 154, no. 4 (2001): 829–40. http://dx.doi.org/10.1083/jcb.200102078.

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Recent studies indicate that insulin stimulation of glucose transporter (GLUT)4 translocation requires at least two distinct insulin receptor–mediated signals: one leading to the activation of phosphatidylinositol 3 (PI-3) kinase and the other to the activation of the small GTP binding protein TC10. We now demonstrate that TC10 is processed through the secretory membrane trafficking system and localizes to caveolin-enriched lipid raft microdomains. Although insulin activated the wild-type TC10 protein and a TC10/H-Ras chimera that were targeted to lipid raft microdomains, it was unable to acti

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3

Terrin, Anna, Stefania Monterisi, Alessandra Stangherlin, et al. "PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome." Journal of Cell Biology 198, no. 4 (2012): 607–21. http://dx.doi.org/10.1083/jcb.201201059.

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Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome. In this paper, we investigate whether a PKA–PDE4D3–AKAP9 complex can generate spatial compartmentalization of cyclic adenosine monophosphate (cAMP) signaling at the centrosome. Real-time imaging of fluorescence resonance energy transfer reporters shows that centrosomal PDE4D3 modulated a dynamic microdomain within which cAMP concentration selectively changed over the cell cycle. AKAP9-anchored, centroso

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Collin, Guillaume, Mélanie Franco, Valérie Simon, Christine Bénistant, and Serge Roche. "The Tom1L1-Clathrin Heavy Chain Complex Regulates Membrane Partitioning of the Tyrosine Kinase Src Required for Mitogenic and Transforming Activities." Molecular and Cellular Biology 27, no. 21 (2007): 7631–40. http://dx.doi.org/10.1128/mcb.00543-07.

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ABSTRACT Compartmentalization of Src tyrosine kinases (SFK) plays an important role in signal transduction induced by a number of extracellular stimuli. For example, Src mitogenic signaling induced by platelet-derived growth factor (PDGF) is initiated in cholesterol-enriched microdomain caveolae. How this Src subcellular localization is regulated is largely unknown. Here we show that the Tom1L1-clathrin heavy chain (CHC) complex negatively regulates the level of SFK in caveolae needed for the induction of DNA synthesis. Tom1L1 is both an interactor and a substrate of SFK. Intriguingly, it stim

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Hong, Dihui, Dov Jaron, Donald G. Buerk, and Kenneth A. Barbee. "Transport-dependent calcium signaling in spatially segregated cellular caveolar domains." American Journal of Physiology-Cell Physiology 294, no. 3 (2008): C856—C866. http://dx.doi.org/10.1152/ajpcell.00278.2007.

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We developed a two-dimensional model of transport-dependent intracellular calcium signaling in endothelial cells (ECs). Our purpose was to evaluate the effects of spatial colocalization of endothelial nitric oxide synthase (eNOS) and capacitative calcium entry (CCE) channels in caveolae on eNOS activation in response to ATP. Caveolae are specialized microdomains of the plasma membrane that contain a variety of signaling molecules to optimize their interactions and regulate their activity. In ECs, these molecules include CCE channels and eNOS. To achieve a quantitative understanding of the mech

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Frolikova, Michaela, Eliska Valaskova, Jiri Cerny, et al. "Addressing the Compartmentalization of Specific Integrin Heterodimers in Mouse Sperm." International Journal of Molecular Sciences 20, no. 5 (2019): 1004. http://dx.doi.org/10.3390/ijms20051004.

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Integrins are transmembrane cell receptors involved in two crucial mechanisms for successful fertilization, namely, mammalian intracellular signaling and cell adhesion. Integrins α6β4, α3β1 and α6β1 are three major laminin receptors expressed on the surface of mammalian cells including gametes, and the presence of individual integrin subunits α3, α6, β1 and β4 has been previously detected in mammalian sperm. However, to date, proof of the existence of individual heterodimer pairs in sperm and their detailed localization is missing. The major conclusion of this study is evidence that the β4 int

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Aota, Hiroyuki, Yotaro Morishima, and Mikiharu Kamachi. "COMPARTMENTALIZATION OF ZINQII) TETRAPHENYLPORPHYRIN IN A HYDROPHOBIC MICRODOMAIN OF AN AMPHIPHILIC POLYELECTROLYTE: A PHYSICOCHEMICAL MODEL OF BIOLOGICAL METALLOPORPHYRIN SYSTEMS." Photochemistry and Photobiology 57, s1 (1993): 989–95. http://dx.doi.org/10.1111/j.1751-1097.1993.tb02960.x.

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8

Marchetti, Marta, Marie-Noelle Monier, Alexandre Fradagrada, et al. "Stat-mediated Signaling Induced by Type I and Type II Interferons (IFNs) Is Differentially Controlled through Lipid Microdomain Association and Clathrin-dependent Endocytosis of IFN Receptors." Molecular Biology of the Cell 17, no. 7 (2006): 2896–909. http://dx.doi.org/10.1091/mbc.e06-01-0076.

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Type I (α/β) and type II (γ) interferons (IFNs) bind to distinct receptors, although they activate the same signal transducer and activator of transcription, Stat1, raising the question of how signal specificity is maintained. Here, we have characterized the sorting of IFN receptors (IFN-Rs) at the plasma membrane and the role it plays in IFN-dependent signaling and biological activities. We show that both IFN-α and IFN-γ receptors are internalized by a classical clathrin- and dynamin-dependent endocytic pathway. Although inhibition of clathrin-dependent endocytosis blocked the uptake of IFN-α

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9

Bavari, Sina, Catharine M. Bosio, Elizabeth Wiegand, et al. "Lipid Raft Microdomains." Journal of Experimental Medicine 195, no. 5 (2002): 593–602. http://dx.doi.org/10.1084/jem.20011500.

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Spatiotemporal aspects of filovirus entry and release are poorly understood. Lipid rafts act as functional platforms for multiple cellular signaling and trafficking processes. Here, we report the compartmentalization of Ebola and Marburg viral proteins within lipid rafts during viral assembly and budding. Filoviruses released from infected cells incorporated raft-associated molecules, suggesting that viral exit occurs at the rafts. Ectopic expression of Ebola matrix protein and glycoprotein supported raft-dependent release of filamentous, virus-like particles (VLPs), strikingly similar to live

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10

Grisan, Francesca, Liliana F. Iannucci, Nicoletta C. Surdo, et al. "PKA compartmentalization links cAMP signaling and autophagy." Cell Death & Differentiation 28, no. 8 (2021): 2436–49. http://dx.doi.org/10.1038/s41418-021-00761-8.

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AbstractAutophagy is a highly regulated degradative process crucial for maintaining cell homeostasis. This important catabolic mechanism can be nonspecific, but usually occurs with fine spatial selectivity (compartmentalization), engaging only specific subcellular sites. While the molecular machines driving autophagy are well understood, the involvement of localized signaling events in this process is not well defined. Among the pathways that regulate autophagy, the cyclic AMP (cAMP)/protein kinase A (PKA) cascade can be compartmentalized in distinct functional units called microdomains. Howev

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11

Olsen, Anne S. B., and Nils J. Færgeman. "Sphingolipids: membrane microdomains in brain development, function and neurological diseases." Open Biology 7, no. 5 (2017): 170069. http://dx.doi.org/10.1098/rsob.170069.

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Sphingolipids are highly enriched in the nervous system where they are pivotal constituents of the plasma membranes and are important for proper brain development and functions. Sphingolipids are not merely structural elements, but are also recognized as regulators of cellular events by their ability to form microdomains in the plasma membrane. The significance of such compartmentalization spans broadly from being involved in differentiation of neurons and synaptic transmission to neuronal–glial interactions and myelin stability. Thus, perturbations of the sphingolipid metabolism can lead to r

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12

Prior, I. A., and J. F. Hancock. "Compartmentalization of Ras proteins." Journal of Cell Science 114, no. 9 (2001): 1603–8. http://dx.doi.org/10.1242/jcs.114.9.1603.

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The Ras GTPases operate as molecular switches that link extracellular stimuli with a diverse range of biological outcomes. Although many studies have concentrated on the protein-protein interactions within the complex signaling cascades regulated by Ras, it is becoming clear that the spatial orientation of different Ras isoforms within the plasma membrane is also critical for their function. H-Ras, N-Ras and K-Ras use different membrane anchors to attach to the plasma membrane. Recently it has been shown that these anchors also act as trafficking signals that direct palmitoylated H-Ras and N-R

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13

Gao, X., P. R. Lowry, X. Zhou, et al. "PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains." Proceedings of the National Academy of Sciences 108, no. 35 (2011): 14509–14. http://dx.doi.org/10.1073/pnas.1019386108.

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14

Zippin, Jonathan H., Yanqiu Chen, Patrick Nahirney, et al. "Compartmentalization of bicarbonate‐sensitive adenylyl cyclase in distinct signaling microdomains." FASEB Journal 17, no. 1 (2002): 82–84. http://dx.doi.org/10.1096/fj.02-0598fje.

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15

Inoue, Mayumi, Shian-Huey Chiang, Louise Chang, Xiao-Wei Chen, and Alan R. Saltiel. "Compartmentalization of the Exocyst Complex in Lipid Rafts Controls Glut4 Vesicle Tethering." Molecular Biology of the Cell 17, no. 5 (2006): 2303–11. http://dx.doi.org/10.1091/mbc.e06-01-0030.

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Lipid raft microdomains act as organizing centers for signal transduction. We report here that the exocyst complex, consisting of Exo70, Sec6, and Sec8, regulates the compartmentalization of Glut4-containing vesicles at lipid raft domains in adipocytes. Exo70 is recruited by the G protein TC10 after activation by insulin and brings with it Sec6 and Sec8. Knockdowns of these proteins block insulin-stimulated glucose uptake. Moreover, their targeting to lipid rafts is required for glucose uptake and Glut4 docking at the plasma membrane. The assembly of this complex also requires the PDZ domain p

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16

Raju, Diana N., Jan N. Hansen, Sebastian Rassmann, et al. "Cyclic Nucleotide-Specific Optogenetics Highlights Compartmentalization of the Sperm Flagellum into cAMP Microdomains." Cells 8, no. 7 (2019): 648. http://dx.doi.org/10.3390/cells8070648.

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Inside the female genital tract, mammalian sperm undergo a maturation process called capacitation, which primes the sperm to navigate across the oviduct and fertilize the egg. Sperm capacitation and motility are controlled by 3′,5′-cyclic adenosine monophosphate (cAMP). Here, we show that optogenetics, the control of cellular signaling by genetically encoded light-activated proteins, allows to manipulate cAMP dynamics in sperm flagella and, thereby, sperm capacitation and motility by light. To this end, we used sperm that express the light-activated phosphodiesterase LAPD or the photo-activate

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17

Russell, Sarah, and Jane Oliaro. "Compartmentalization in T‐cell signalling: Membrane microdomains and polarity orchestrate signalling and morphology." Immunology & Cell Biology 84, no. 1 (2006): 107–13. http://dx.doi.org/10.1111/j.1440-1711.2005.01415.x.

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18

Dityatev, Alexander, Constanze I. Seidenbecher, and Melitta Schachner. "Compartmentalization from the outside: the extracellular matrix and functional microdomains in the brain." Trends in Neurosciences 33, no. 11 (2010): 503–12. http://dx.doi.org/10.1016/j.tins.2010.08.003.

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19

Murabito, Alessandra, Sophie Cnudde, Emilio Hirsch, and Alessandra Ghigo. "Potential therapeutic applications of AKAP disrupting peptides." Clinical Science 134, no. 24 (2020): 3259–82. http://dx.doi.org/10.1042/cs20201244.

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Abstract The 3′–5′-cyclic adenosine monophosphate (cAMP)/PKA pathway represents a major target for pharmacological intervention in multiple disease conditions. Although the last decade saw the concept of highly compartmentalized cAMP/PKA signaling consolidating, current means for the manipulation of this pathway still do not allow to specifically intervene on discrete cAMP/PKA microdomains. Since compartmentalization is crucial for action specificity, identifying new tools that allow local modulation of cAMP/PKA responses is an urgent need. Among key players of cAMP/PKA signaling compartmental

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20

Sadek, Mirna S., Eleder Cachorro, Ali El-Armouche, and Susanne Kämmerer. "Therapeutic Implications for PDE2 and cGMP/cAMP Mediated Crosstalk in Cardiovascular Diseases." International Journal of Molecular Sciences 21, no. 20 (2020): 7462. http://dx.doi.org/10.3390/ijms21207462.

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Phosphodiesterases (PDEs) are the principal superfamily of enzymes responsible for degrading the secondary messengers 3′,5′-cyclic nucleotides cAMP and cGMP. Their refined subcellular localization and substrate specificity contribute to finely regulate cAMP/cGMP gradients in various cellular microdomains. Redistribution of multiple signal compartmentalization components is often perceived under pathological conditions. Thereby PDEs have long been pursued as therapeutic targets in diverse disease conditions including neurological, metabolic, cancer and autoimmune disorders in addition to numero

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21

Faruque, Omar M., Dung Le-Nguyen, Anne-Dominique Lajoix, et al. "Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring." American Journal of Physiology-Cell Physiology 296, no. 2 (2009): C306—C316. http://dx.doi.org/10.1152/ajpcell.00216.2008.

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Stimulation of numerous G protein-coupled receptors leads to the elevation of intracellular concentrations of cAMP, which subsequently activates the PKA pathway. Specificity of the PKA signaling module is determined by a sophisticated subcellular targeting network that directs the spatiotemporal activation of the kinase. This specific compartmentalization mechanism occurs through high-affinity interactions of PKA with A-kinase anchoring proteins (AKAPs), the role of which is to target the kinase to discrete subcellular microdomains. Recently, a peptide designated “AKAPis” has been proposed to

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22

He, Jinlong, Zhen Cui, and Yi Zhu. "The role of caveolae in endothelial dysfunction." Medical Review 1, no. 1 (2021): 78–91. http://dx.doi.org/10.1515/mr-2021-0005.

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Abstract Caveolae, the specialized cell-surface plasma membrane invaginations which are abundant in endothelial cells, play critical roles in regulating various cellular processes, including cholesterol homeostasis, nitric oxide production, and signal transduction. Endothelial caveolae serve as a membrane platform for compartmentalization, modulation, and integration of signal events associated with endothelial nitric oxide synthase, ATP synthase β, and integrins, which are involved in the regulation of endothelial dysfunction and related cardiovascular diseases, such as atherosclerosis and hy

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23

Harder, Thomas. "Formation of functional cell membrane domains: the interplay of lipid– and protein–mediated interactions." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 358, no. 1433 (2003): 863–68. http://dx.doi.org/10.1098/rstb.2003.1274.

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Numerous cell membrane associated processes, including signal transduction, membrane sorting, protein processing and virus trafficking take place in membrane subdomains. Protein–protein interactions provide the frameworks necessary to generate biologically functional membrane domains. For example, coat proteins define membrane areas destined for sorting processes, viral proteins self–assemble to generate a budding virus, and adapter molecules organize multimolecular signalling assemblies, which catalyse downstream reactions. The concept of raft lipid–based membrane domains provides a different

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Casares, Doralicia, Pablo V. Escribá, and Catalina Ana Rosselló. "Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues." International Journal of Molecular Sciences 20, no. 9 (2019): 2167. http://dx.doi.org/10.3390/ijms20092167.

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Biological membranes are key elements for the maintenance of cell architecture and physiology. Beyond a pure barrier separating the inner space of the cell from the outer, the plasma membrane is a scaffold and player in cell-to-cell communication and the initiation of intracellular signals among other functions. Critical to this function is the plasma membrane compartmentalization in lipid microdomains that control the localization and productive interactions of proteins involved in cell signal propagation. In addition, cells are divided into compartments limited by other membranes whose integ

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Vallés, Ana Sofía, and Francisco J. Barrantes. "Interactions between the Nicotinic and Endocannabinoid Receptors at the Plasma Membrane." Membranes 12, no. 8 (2022): 812. http://dx.doi.org/10.3390/membranes12080812.

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Compartmentalization, together with transbilayer and lateral asymmetries, provide the structural foundation for functional specializations at the cell surface, including the active role of the lipid microenvironment in the modulation of membrane-bound proteins. The chemical synapse, the site where neurotransmitter-coded signals are decoded by neurotransmitter receptors, adds another layer of complexity to the plasma membrane architectural intricacy, mainly due to the need to accommodate a sizeable number of molecules in a minute subcellular compartment with dimensions barely reaching the micro

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Delrue, Charlotte, Reinhart Speeckaert, Rafael Noal Moresco, and Marijn M. Speeckaert. "Cyclic Adenosine Monophosphate Signaling in Chronic Kidney Disease: Molecular Targets and Therapeutic Potentials." International Journal of Molecular Sciences 25, no. 17 (2024): 9441. http://dx.doi.org/10.3390/ijms25179441.

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Chronic kidney disease (CKD) is characterized by a steady decline in kidney function and affects roughly 10% of the world’s population. This review focuses on the critical function of cyclic adenosine monophosphate (cAMP) signaling in CKD, specifically how it influences both protective and pathogenic processes in the kidney. cAMP, a critical secondary messenger, controls a variety of cellular functions, including transcription, metabolism, mitochondrial homeostasis, cell proliferation, and apoptosis. Its compartmentalization inside cellular microdomains ensures accurate signaling. In kidney ph

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Willett, Mark, Michele Brocard, Alexandre Davide, and Simon J. Morley. "Translation initiation factors and active sites of protein synthesis co-localize at the leading edge of migrating fibroblasts." Biochemical Journal 438, no. 1 (2011): 217–27. http://dx.doi.org/10.1042/bj20110435.

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Cell migration is a highly controlled essential cellular process, often dysregulated in tumour cells, dynamically controlled by the architecture of the cell. Studies involving cellular fractionation and microarray profiling have previously identified functionally distinct mRNA populations specific to cellular organelles and architectural compartments. However, the interaction between the translational machinery itself and cellular structures is relatively unexplored. To help understand the role for the compartmentalization and localized protein synthesis in cell migration, we have used scannin

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Poenie, Martin, Akwasi Minta, and Charles Vorndran. "A new family of fluorescent calcium indicators designed to resist leakage or for measuring calcium near membranes." Proceedings, annual meeting, Electron Microscopy Society of America 52 (1994): 168–69. http://dx.doi.org/10.1017/s0424820100168578.

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The use of fura-2 as an intracellular calcium indicator is complicated by problems of rapid dye leakage and intracellular compartmentalization which is due to a probenecid sensitive anion transporter. In addition there is increasing evidence for localized microdomains of high calcium signals which may not be faithfully reported by fura-2.We have developed a new family of fura-2 analogs aimed at addressing some of these problems. These new indicators are based on a modified bapta which can be readily derivatized to produce fura-2 analogs with a variety of new properties. The modifications do no

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Matallanas, David, Victoria Sanz-Moreno, Imanol Arozarena, et al. "Distinct Utilization of Effectors and Biological Outcomes Resulting from Site-Specific Ras Activation: Ras Functions in Lipid Rafts and Golgi Complex Are Dispensable for Proliferation and Transformation." Molecular and Cellular Biology 26, no. 1 (2006): 100–116. http://dx.doi.org/10.1128/mcb.26.1.100-116.2006.

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ABSTRACT Ras proteins are distributed in different types of plasma membrane microdomains and endomembranes. However, how microlocalization affects the signals generated by Ras and its subsequent biological outputs is largely unknown. We have approached this question by selectively targeting RasV12 to different cellular sublocalizations. We show here that compartmentalization dictates Ras utilization of effectors and the intensity of its signals. Activated Ras can evoke enhanced proliferation and transformation from most of its platforms, with the exception of the Golgi complex. Furthermore, si

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Sontag, Jean-Marie, Viyada Nunbhakdi-Craig, and Estelle Sontag. "Leucine Carboxyl Methyltransferase 1 (LCMT1)-dependent Methylation Regulates the Association of Protein Phosphatase 2A and Tau Protein with Plasma Membrane Microdomains in Neuroblastoma Cells." Journal of Biological Chemistry 288, no. 38 (2013): 27396–405. http://dx.doi.org/10.1074/jbc.m113.490102.

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Down-regulation of protein phosphatase 2A (PP2A) methylation occurs in Alzheimer disease (AD). However, the regulation of PP2A methylation remains poorly understood. We have reported that altered leucine carboxyl methyltransferase (LCMT1)-dependent PP2A methylation is associated with down-regulation of PP2A holoenzymes containing the Bα subunit (PP2A/Bα) and subsequent accumulation of phosphorylated Tau in N2a cells, in vivo and in AD. Here, we show that pools of LCMT1, methylated PP2A, and PP2A/Bα are co-enriched in cholesterol-rich plasma membrane microdomains/rafts purified from N2a cells.

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Mesa-Herrera, Taoro-González, Valdés-Baizabal, Diaz, and Marín. "Lipid and Lipid Raft Alteration in Aging and Neurodegenerative Diseases: A Window for the Development of New Biomarkers." International Journal of Molecular Sciences 20, no. 15 (2019): 3810. http://dx.doi.org/10.3390/ijms20153810.

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Lipids in the brain are major components playing structural functions as well as physiological roles in nerve cells, such as neural communication, neurogenesis, synaptic transmission, signal transduction, membrane compartmentalization, and regulation of gene expression. Determination of brain lipid composition may provide not only essential information about normal brain functioning, but also about changes with aging and diseases. Indeed, deregulations of specific lipid classes and lipid homeostasis have been demonstrated in neurodegenerative disorders such as Alzheimer’s disease (AD) and Park

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Christie, Darah, Isaac Elias, Luan Chau, et al. "SLP-2 regulates T cell activation by optimizing cardiolipin compartmentalization in mitochondrial membranes and enhancing cellular respiration (178.7)." Journal of Immunology 188, no. 1_Supplement (2012): 178.7. http://dx.doi.org/10.4049/jimmunol.188.supp.178.7.

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Abstract Stomatin-like protein 2 (SLP-2) is a mitochondrial protein of the highly conserved Stomatin, Prohibitin, Flotillin, HflC/K superfamily. The function of SLP-2 has remained unclear but members of this superfamily have been linked to membrane organization. We have previously reported that SLP-2 partitions within glycolipid-enriched, detergent-insoluble microdomains, and its expression is up-regulated upon T cell activation. This correlates with increased mitochondrial biogenesis and function. Using human inducible over-expression/down-regulation systems and newly generated T cell-specifi

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Saumell-Esnaola, Miquel, Sergio Barrondo, Gontzal García del Caño, et al. "Subsynaptic Distribution, Lipid Raft Targeting and G Protein-Dependent Signalling of the Type 1 Cannabinoid Receptor in Synaptosomes from the Mouse Hippocampus and Frontal Cortex." Molecules 26, no. 22 (2021): 6897. http://dx.doi.org/10.3390/molecules26226897.

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Numerous studies have investigated the roles of the type 1 cannabinoid receptor (CB1) in glutamatergic and GABAergic neurons. Here, we used the cell-type-specific CB1 rescue model in mice to gain insight into the organizational principles of plasma membrane targeting and Gαi/o protein signalling of the CB1 receptor at excitatory and inhibitory terminals of the frontal cortex and hippocampus. By applying biochemical fractionation techniques and Western blot analyses to synaptosomal membranes, we explored the subsynaptic distribution (pre-, post-, and extra-synaptic) and CB1 receptor compartment

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Mora, Rosalia C., Vera L. Bonilha, Bo-Chul Shin, et al. "Bipolar assembly of caveolae in retinal pigment epithelium." American Journal of Physiology-Cell Physiology 290, no. 3 (2006): C832—C843. http://dx.doi.org/10.1152/ajpcell.00405.2005.

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Caveolae and their associated structural proteins, the caveolins, are specialized plasmalemmal microdomains involved in endocytosis and compartmentalization of cell signaling. We examined the expression and distribution of caveolae and caveolins in retinal pigment epithelium (RPE), which plays key roles in retinal support, visual cycle, and acts as the main barrier between blood and retina. Electron microscopic observation of rat RPE, in situ primary cultures of rat and human RPE and a rat RPE cell line (RPE-J) demonstrated in all cases the presence of caveolae in both apical and basolateral d

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Hoshijima, Masahiko. "Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures." American Journal of Physiology-Heart and Circulatory Physiology 290, no. 4 (2006): H1313—H1325. http://dx.doi.org/10.1152/ajpheart.00816.2005.

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Cardiac muscle is equipped with intricate intrinsic mechanisms to regulate adaptive remodeling. Recent and extensive experimental findings powered by novel strategies for screening protein-protein interactions, improved imaging technologies, and versatile transgenic mouse methodologies reveal that Z disks and titin filaments possess unexpectedly complicated sensory and modulatory mechanisms for signal reception and transduction. These mechanisms employ molecules such as muscle-enriched LIM domain proteins, PDZ-LIM domain proteins, myozenin gene family members, titin-associated ankyrin repeat f

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Garg, Varsha, Aleksandra Hackel, and Christina Kühn. "Subcellular Targeting of Plant Sucrose Transporters Is Affected by Their Oligomeric State." Plants 9, no. 2 (2020): 158. http://dx.doi.org/10.3390/plants9020158.

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Post-translational regulation of sucrose transporters represents one possibility to adapt transporter activity in a very short time frame. This can occur either via phosphorylation/dephosphorylation, oligomerization, protein–protein interactions, endocytosis/exocytosis, or degradation. It is also known that StSUT1 can change its compartmentalization at the plasma membrane and concentrate in membrane microdomains in response to changing redox conditions. A systematic screen for protein–protein-interactions of plant sucrose transporters revealed that the interactome of all three known sucrose tr

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Wang, Hong X., Lois M. Douglas, Petra Veselá, Reinhard Rachel, Jan Malinsky, and James B. Konopka. "Eisosomes promote the ability of Sur7 to regulate plasma membrane organization inCandida albicans." Molecular Biology of the Cell 27, no. 10 (2016): 1663–75. http://dx.doi.org/10.1091/mbc.e16-01-0065.

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The plasma membrane of the fungal pathogen Candida albicans forms a protective barrier that also mediates many processes needed for virulence, including cell wall synthesis, invasive hyphal morphogenesis, and nutrient uptake. Because compartmentalization of the plasma membrane is believed to coordinate these diverse activities, we examined plasma membrane microdomains termed eisosomes or membrane compartment of Can1 (MCC), which correspond to ∼200-nm-long furrows in the plasma membrane. A pil1∆ lsp1∆ mutant failed to form eisosomes and displayed strong defects in plasma membrane organization a

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Meiri, Karina F. "Lipid rafts and regulation of the cytoskeleton during T cell activation." Philosophical Transactions of the Royal Society B: Biological Sciences 360, no. 1461 (2005): 1663–72. http://dx.doi.org/10.1098/rstb.2005.1704.

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The ability of polarized cells to initiate and sustain directional responses to extracellular signals is critically dependent on direct communication between spatially organized signalling modules in the membrane and the underlying cytoskeleton. Pioneering work in T cells has shown that the assembly of signalling modules critically depends on the functional compartmentalization of membrane lipids into ordered microdomains or lipid rafts. The significance of rafts in T cell activation lies not only in their ability to recruit the signalling partners that eventually assemble into a mature immuno

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Wang, Renjun, Min Wang, Dongshu Du, Zhiying Shan, Lanrong Bi, and Qing-Hui Chen. "Brain-Targeted Reactive Oxygen Species in Hypertension: Unveiling Subcellular Dynamics, Immune Cross-Talk, and Novel Therapeutic Pathways." Antioxidants 14, no. 4 (2025): 408. https://doi.org/10.3390/antiox14040408.

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Hypertension (HTN) is a complex disease with significant global health implications, driven by neural and oxidative mechanisms. Reactive oxygen species (ROS), once considered mere metabolic byproducts, are now recognized as one of the key contributors to dysfunction of the autonomic nerve system, which involves the onset and progression of HTN. This review highlights the dynamic roles of ROS in neuronal signaling, subcellular compartmentalization, and brain–immune interactions, focusing on their impacts on synaptic remodeling, neuroinflammation, and epigenetic modifications within key autonomi

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Pannabecker, Thomas L. "Loop of Henle interaction with interstitial nodal spaces in the renal inner medulla." American Journal of Physiology-Renal Physiology 295, no. 6 (2008): F1744—F1751. http://dx.doi.org/10.1152/ajprenal.90483.2008.

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Understanding dynamics of NaCl reabsorption from loops of Henle, and cellular and physiological consequences, requires a clear understanding of the structural relationships of loops with other functional elements of the inner medulla (IM). Pathways taken by ascending thin limbs (ATLs) and prebend segments along the corticopapillary axis were evaluated for the outer zone of the IM of the Munich-Wistar rat. Connectivity between these segments and microdomains of interstitium adjacent to collecting ducts (CDs) and abutting ascending vasa recta (interstitial nodal spaces) was assessed by evaluatin

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Boerth, Nancy J., Jeffrey J. Sadler, Daniel E. Bauer, James L. Clements, Shereen M. Gheith, and Gary A. Koretzky. "Recruitment of Slp-76 to the Membrane and Glycolipid-Enriched Membrane Microdomains Replaces the Requirement for Linker for Activation of T Cells in T Cell Receptor Signaling." Journal of Experimental Medicine 192, no. 7 (2000): 1047–58. http://dx.doi.org/10.1084/jem.192.7.1047.

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Two hematopoietic-specific adapters, src homology 2 domain–containing leukocyte phosphoprotein of 76 kD (SLP-76) and linker for activation of T cells (LAT), are critical for T cell development and T cell receptor (TCR) signaling. Several studies have suggested that SLP-76 and LAT function coordinately to promote downstream signaling. In support of this hypothesis, we find that a fraction of SLP-76 localizes to glycolipid-enriched membrane microdomains (GEMs) after TCR stimulation. This recruitment of SLP-76 requires amino acids 224–244. The functional consequences of targeting SLP-76 to GEMs f

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Hayashi, Teruo, та Tsung-Ping Su. "σ-1 Receptors (σ1 Binding Sites) Form Raft-Like Microdomains and Target Lipid Droplets on the Endoplasmic Reticulum: Roles in Endoplasmic Reticulum Lipid Compartmentalization and Export". Journal of Pharmacology and Experimental Therapeutics 306, № 2 (2003): 718–25. http://dx.doi.org/10.1124/jpet.103.051284.

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Awasthi, Vineet, Samir Mandal, Veena Papanna, L. Vijaya Mohan Rao, and Usha Pendurthi. "Modulation of Tissue Factor-Factor VIIa Signaling by Lipid Rafts and Caveolae." Blood 108, no. 11 (2006): 1744. http://dx.doi.org/10.1182/blood.v108.11.1744.1744.

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Abstract Tissue factor (TF) is a cellular receptor for clotting factor VIIa (VIIa) and the formation of TF-VIIa complexes on cell surfaces not only triggers the coagulation cascade but also transduces cell signaling via activation of protease-activated receptors (PARs), particularly PAR2. Although a number of recent studies provide valuable information on intracellular signaling pathways that are activated by TF-VIIa, the role of various cell surface components in mediating the interaction of TF-VIIa with PARs, and the subsequent signal transmittance are unknown. Unlike thrombin and trypsin, V

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Plattner, Helmut, and Alexei Verkhratsky. "Inseparable tandem: evolution chooses ATP and Ca 2+ to control life, death and cellular signalling." Philosophical Transactions of the Royal Society B: Biological Sciences 371, no. 1700 (2016): 20150419. http://dx.doi.org/10.1098/rstb.2015.0419.

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From the very dawn of biological evolution, ATP was selected as a multipurpose energy-storing molecule. Metabolism of ATP required intracellular free Ca 2+ to be set at exceedingly low concentrations, which in turn provided the background for the role of Ca 2+ as a universal signalling molecule. The early-eukaryote life forms also evolved functional compartmentalization and vesicle trafficking, which used Ca 2+ as a universal signalling ion; similarly, Ca 2+ is needed for regulation of ciliary and flagellar beat, amoeboid movement, intracellular transport, as well as of numerous metabolic proc

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Lisanti, M. P., P. E. Scherer, J. Vidugiriene, et al. "Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease." Journal of Cell Biology 126, no. 1 (1994): 111–26. http://dx.doi.org/10.1083/jcb.126.1.111.

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Caveolae are 50-100-nm membrane microdomains that represent a subcompartment of the plasma membrane. Previous morphological studies have implicated caveolae in (a) the transcytosis of macromolecules (including LDL and modified LDLs) across capillary endothelial cells, (b) the uptake of small molecules via a process termed potocytosis involving GPI-linked receptor molecules and an unknown anion transport protein, (c) interactions with the actin-based cytoskeleton, and (d) the compartmentalization of certain signaling molecules, including G-protein coupled receptors. Caveolin, a 22-kD integral m

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Li, Tsai-Ning, Yu-Jung Chen, Ting-Yi Lu, You-Tung Wang, Hsin-Chieh Lin, and Chi-Kuang Yao. "A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila." eLife 9 (December 10, 2020). http://dx.doi.org/10.7554/elife.60125.

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Synaptic vesicle (SV) endocytosis is coupled to exocytosis to maintain SV pool size and thus neurotransmitter release. Intense stimulation induces activity-dependent bulk endocytosis (ADBE) to recapture large quantities of SV constituents in large endosomes from which SVs reform. How these consecutive processes are spatiotemporally coordinated remains unknown. Here, we show that Flower Ca2+ channel-dependent phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) compartmentalization governs control of these processes in Drosophila. Strong stimuli trigger PI(4,5)P2 microdomain formation at periactiv

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Pavlaki, Nikoleta, Alexander Froese, Wener Li, et al. "Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation." Cardiovascular Research, May 22, 2024. http://dx.doi.org/10.1093/cvr/cvae094.

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Abstract Aims Gene therapy with cardiac phosphodiesterases (PDEs) such as PDE4B has recently been described to effectively prevent heart failure in mice. However, exact molecular mechanisms of its beneficial effects, apart from general lowering of cardiomyocyte cyclic adenosine monophosphate (cAMP) levels, have not been elucidated. Here we studied whether gene therapy with two types of PDEs, namely PDE2A and PDE4B, can prevent pressure-overload induced heart failure in mice by acting on and restoring altered cAMP compartmentalization in distinct subcellular microdomains. Methods and results He

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Leung, A., D. Ohadi, G. Pekkurnaz, and P. Rangamani. "Systems modeling predicts that mitochondria ER contact sites regulate the postsynaptic energy landscape." npj Systems Biology and Applications 7, no. 1 (2021). http://dx.doi.org/10.1038/s41540-021-00185-7.

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AbstractSpatiotemporal compartmentation of calcium dynamics is critical for neuronal function, particularly in postsynaptic spines. This exquisite level of Ca2+ compartmentalization is achieved through the storage and release of Ca2+ from various intracellular organelles particularly the endoplasmic reticulum (ER) and the mitochondria. Mitochondria and ER are established storage organelles controlling Ca2+ dynamics in neurons. Mitochondria also generate a majority of energy used within postsynaptic spines to support the downstream events associated with neuronal stimulus. Recently, high resolu

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Molon, Barbara, Cristina Liboni, and Antonella Viola. "CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse." Frontiers in Immunology 13 (August 2, 2022). http://dx.doi.org/10.3389/fimmu.2022.938004.

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T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert their functions requiring high sensibility and specificity, T cells need to integrate different stimuli from the surrounding microenvironment. A finely tuned signalling compartmentalization orchestrated in dynamic platforms is an essential requirement for the proper and efficient response of these cells to distinct triggers. During years, several studies have depicted the pivotal role of the cytoskeleton and lipid microdomains in controlling signalling compartmentalization dur

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Anagnostopoulou, Aikaterini, Livia L. Camargo, Daniel Rodrigues, Augusto C. Montezano, and Rhian M. Touyz. "Importance of cholesterol-rich microdomains in the regulation of Nox isoforms and redox signaling in human vascular smooth muscle cells." Scientific Reports 10, no. 1 (2020). http://dx.doi.org/10.1038/s41598-020-73751-4.

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Abstract Vascular smooth muscle cell (VSMC) function is regulated by Nox-derived reactive oxygen species (ROS) and redox-dependent signaling in discrete cellular compartments. Whether cholesterol-rich microdomains (lipid rafts/caveolae) are involved in these processes is unclear. Here we examined the sub-cellular compartmentalization of Nox isoforms in lipid rafts/caveolae and assessed the role of these microdomains in VSMC ROS production and pro-contractile and growth signaling. Intact small arteries and primary VSMCs from humans were studied. Vessels from Cav-1−/− mice were used to test proo

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