Academic literature on the topic 'Microdomain organisation'

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Journal articles on the topic "Microdomain organisation"

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Röder, Ira Verena, Valentina Lissandron, Jessica Martin, et al. "PKA microdomain organisation and cAMP handling in healthy and dystrophic muscle in vivo." Cellular Signalling 21, no. 5 (2009): 819–26. http://dx.doi.org/10.1016/j.cellsig.2009.01.029.

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Lechner, Bob-Dan, Paul Smith, Beth McGill, et al. "The Effects of Cholesterol Oxidation on Erythrocyte Plasma Membranes: A Monolayer Study." Membranes 12, no. 9 (2022): 828. http://dx.doi.org/10.3390/membranes12090828.

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Cholesterol plays a key role in the molecular and mesoscopic organisation of lipid membranes and it is expected that changes in its molecular structure (e.g., through environmental factors such as oxidative stress) may affect adversely membrane properties and function. In this study, we present evidence that oxidation of cholesterol has significant effects on the mechanical properties, molecular and mesoscopic organisation and lipid–sterol interactions in condensed monolayers composed of the main species found in the inner leaflet of the erythrocyte membrane. Using a combination of experimenta
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Janas, T., K. Nowotarski, W. I. Gruszecki, and T. Janas. "The effect of hexadecaprenol on molecular organisation and transport properties of model membranes." Acta Biochimica Polonica 47, no. 3 (2000): 661–73. http://dx.doi.org/10.18388/abp.2000_3987.

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The Langmuir monolayer technique and voltammetric analysis were used to investigate the properties of model lipid membranes prepared from dioleoylphosphatidylcholine (DOPC), hexadecaprenol (C80), and their mixtures. Surface pressure-molecular area isotherms, current-voltage characteristics, and membrane conductance-temperature were measured. Molecular area isobars, specific molecular areas, excess free energy of mixing, collapse pressure and collapse area were determined for lipid monolayers. Membrane conductance, activation energy of ion migration across the membrane, and membrane permeabilit
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Viljetić, Barbara, Senka Blažetić, Irena Labak, et al. "Lipid Rafts: The Maestros of Normal Brain Development." Biomolecules 14, no. 3 (2024): 362. http://dx.doi.org/10.3390/biom14030362.

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Lipid rafts, specialised microdomains within cell membranes, play a central role in orchestrating various aspects of neurodevelopment, ranging from neural differentiation to the formation of functional neuronal networks. This review focuses on the multifaceted involvement of lipid rafts in key neurodevelopmental processes, including neural differentiation, synaptogenesis and myelination. Through the spatial organisation of signalling components, lipid rafts facilitate precise signalling events that determine neural fate during embryonic development and in adulthood. The evolutionary conservati
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Fantini, Jacques, Nicolas Garmy, Radhia Mahfoud, and Nouara Yahi. "Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases." Expert Reviews in Molecular Medicine 4, no. 27 (2002): 1–22. http://dx.doi.org/10.1017/s1462399402005392.

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The fluid mosaic model of the plasma membrane has evolved considerably since its original formulation 30 years ago. Membrane lipids do not form a homogeneous phase consisting of glycerophospholipids (GPLs) and cholesterol, but a mosaic of domains with unique biochemical compositions. Among these domains, those containing sphingolipids and cholesterol, referred to as membrane or lipid rafts, have received much attention in the past few years. Lipid rafts have unique physicochemical properties that direct their organisation into liquid-ordered phases floating in a liquid-crystalline ocean of GPL
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Bernard, Chiara, Angelo Rosario Carotenuto, Nicola Maria Pugno, Massimiliano Fraldi, and Luca Deseri. "Modelling lipid rafts formation through chemo-mechanical interplay triggered by receptor–ligand binding." Biomechanics and Modeling in Mechanobiology, December 7, 2023. http://dx.doi.org/10.1007/s10237-023-01787-2.

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AbstractCell membranes, mediator of many biological mechanisms from adhesion and metabolism up to mutation and infection, are highly dynamic and heterogeneous environments exhibiting a strong coupling between biochemical events and structural re-organisation. This involves conformational changes induced, at lower scales, by lipid order transitions and by the micro-mechanical interplay of lipids with transmembrane proteins and molecular diffusion. Particular attention is focused on lipid rafts, ordered lipid microdomains rich of signalling proteins, that co-localise to enhance substance traffic
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Dissertations / Theses on the topic "Microdomain organisation"

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Eichel, Catherine. "Organisation et régulation des canaux sodiques et potassiques cardiaques par les protéines MAGUK." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066157/document.

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L'objectif de ce travail a été de comprendre comment les canaux ioniques sont adressés, organisés et régulés dans des domaines spécialisés de la membrane plasmique des cardiomyocytes. Parmi les partenaires des canaux, les protéines MAGUK (Membrane Associated GUanylate Kinase) sont spécialisées dans l'ancrage, l'agrégation et la formation de complexes macromoléculaires à la membrane. J'ai caractérisé pour la première fois au niveau cardiaque une de ces protéines MAGUK, la protéine CASK. CASK est localisée à la membrane latérale des cardiomyocytes et exclue des disques intercalaires, zones de co
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Toubiana, Julie. "Signalisation de TLR2, organisation et variabilité de la réponse immunitaire innée." Paris 5, 2010. http://www.theses.fr/2010PA05T016.

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L'invasion de l'hôte par un pathogène induit une réponse immunitaire innée qui aboutit à l'activation cellulaire, à une réaction inflammatoire et parfois à l'initiation d'une immunité acquise. Des différences fondamentales existent dans l'organisation de la réponse immune innée à un pathogène, d'une cellule , d'un organe, ou d'un individu à l'autre. L'organisation de la réponse immune innée en réponse à l'invasion bactérienne, parasitaire ou fongique nécessitent la coopération du récepteur de type Toll 2 (TLR2) avec TLR1 ou TLR6 et la formation de complexes d'activation dans les radeaux lipidi
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Bezzaoucha, Fatiha. "Nouveaux polyamphiphiles cationiques : synthèse et étude de leur organisation en milieu aqueux et aux interfaces en relation avec leur structure." Thesis, Vandoeuvre-les-Nancy, INPL, 2008. http://www.theses.fr/2008INPL026N/document.

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Dans le but d’approfondir les connaissances fondamentales entre la structure des polymères associatifs intramoléculaires (polysavons) et leurs propriétés physico-chimiques en milieux aqueux, trois nouvelles familles de polymères amphiphiles cationiques ont été synthétisées par deux méthodes complémentaires permettant une grande variabilité de structure. Les polymères obtenus sont des poly(méth)acrylamides en peigne avec des groupes latéraux de type ammonium quaternaire portant une chaîne alkyle de taille variable. Une étude du comportement physico-chimique de ces polymères en solution, par vis
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Schäfers, Sonja [Verfasser]. "Annexin A2 in membrane microdomain organisation and influenza A infection / vorgelegt von Sonja Schäfers." 2010. http://d-nb.info/1003549209/34.

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Medvedev, Roman. "Structural and functional differences between cardiomyocytes from right and left ventricles in health and disease." Doctoral thesis, 2020. http://hdl.handle.net/11562/1017728.

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Several disorders including pulmonary hypertension (PH) and heart failure (HF) could lead to right ventricle (RV) hypertrophy and failure. RV failure is one of the most important prognostic factors for morbidity and mortality in these disorders. However, there is still no therapy to prevent the RV hypertrophy in PH. Treatments developed for the left ventricle (LV) failure do not improve the survival in patients with RV failure probably due to the significant differences in the chambers physiology and hemodynamic function. A better understanding of the cellular and molecular mechanisms of RV hy
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Sieber, Jochen Josef. "Der Syntaxin 1-Cluster - Organisation und Dynamik einer supramolekularen Struktur der Plasmamembran." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-0006-AC62-5.

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