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Dissertations / Theses on the topic 'Microfluidic device'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Huffman, Jamie. "Design of a microfluidic device for lymphatic biology." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42886.

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The lymphatic system has three primary roles: transporting lipids, transporting immune cells, and maintaining fluid balance. Each one of these roles are influenced by the presence of flow. Inflammation increases lymph flow, lipid uptake is enhanced by flow, cancer cell migration increases in the presence of flow, and lymphatic permeability and lymphatic contractility respond to changes in flow. Flow is very important to lymphatic function, and yet, there are no in vitro models that incorporate both luminal (flow along cell lumen) and transmural (flow through cell lumina) flow for lymphatics. T

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2

Jackson, Kirsten Marie. "Magnetostatic Modeling for Microfluidic Device Design." DigitalCommons@CalPoly, 2011. https://digitalcommons.calpoly.edu/theses/518.

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Magnetostatic Modeling for Microfluidic Device Design Kirsten Marie Jackson For several years, biologists have used superparamagnetic beads to facilitate biological separations. More recently, researchers have adopted this approach in microfluidic devices [1-3]. This recent development and use of superparamagnetic particles in biomedical and biological applications have resulted in a necessity for methods that enable the understanding and prediction of their properties and actions during use. Typically, such methods would involve simple experimentation prior to in vitro experimentation, animal

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3

Zhang, Rou. "Application of microfluidic device to malaria diagnosis." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/42130.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007.<br>"September 2007."<br>Includes bibliographical references (p. 45-47).<br>Of many diagnostic devices and technology developed, microfluidics could be superior in terms of ease of fabrication, cost, portability, speed and sensitivity. The application of diagnosis of malaria infection by microfluidics is studied. Malaria infected red blood cells will cause a cell stiffening, and the different behaviors of iRBCs could be detected by microfluidics. The malaria market and various business mod

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4

Foley, John J. "Microfluidic Electrical Impedance Spectroscopy." DigitalCommons@CalPoly, 2018. https://digitalcommons.calpoly.edu/theses/1950.

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The goal of this study is to design and manufacture a microfluidic device capable of measuring changes in impedance valuesof microfluidic cell cultures. Tocharacterize this, an interdigitated array of electrodes was patterned over glass, where it was then bonded to a series of fluidic networks created in PDMS via soft lithography. The device measured ethanol impedance initially to show that values remain consistent over time. Impedance values of water and 1% wt. saltwater were compared to show that the device is able to detect changes in impedance, with up to a 60% reduction in electrical impe

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5

Starr, Kameron D. "Microfluidic Device for Phenotype-Dependent Cell Agility Differentiation and Corresponding Device Sensory Implementation." Ohio University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1502896489271416.

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6

Andar, Abhay U. "Development of a microfluidic device to test nanoparticle toxicity." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/2410/.

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Recent years have seen a growth in the manufacturing of nanoparticles for their uses in various fields of science and technology. However, this explosion in the production and use of nanoparticles has in turn resulted in growing concerns regarding their impact on public health and the environment (Hoet, 2004). One major route of entry into the human body is through the air-blood barrier in the lungs. The air-blood barrier at the alveolar region in most mammals is normally about 500-600 nm in thickness (Bartels, 1979) and is mainly responsible for the selective transport of gases and certain vi

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7

Guo, Quan. "Microfluidic device for measuring the deformability of single cells." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42096.

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The deformability of single cells can be used as a biomarker to evaluate the status of many diseases including cancer, malaria, and arthritis. Traditional techniques for measuring single cell deformability, such as micropipette aspiration, optical tweezers, and atomic force microscopy, involve delicate experiments performed by highly-skilled technicians using specialized equipment. This thesis presents a new mechanism for measuring the deformability of single cell using the pressure required to deform single cells through a micro-scale constriction. This technique is in principle similar to th

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8

Shaw, Kirsty Jane. "Integrated DNA extraction and amplification on a microfluidic device." Thesis, University of Hull, 2009. http://hydra.hull.ac.uk/resources/hull:2414.

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An evaluation of DNA extraction and amplification performed in microfluidic systems was carried out, with the aim of integrating the two processes in a single microfluidic device. This integrated device will then be incorporated upstream of capillary gel electrophoresis and fluorescence-based detection for development of a completely integrated genetic analysis system. DNA extraction was performed using a silica substrate with both hydrodynamic and electro-osmotic pumping (EOP), resulting in maximum DNA extraction efficiencies of 82% and 52% respectively under optimised conditions. While the D

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9

Gregoratto, Ivano. "Development of a microfluidic device for continuous particle fractionation." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438024.

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10

JING, GAOSHAN. "CULTURE-BASED MICROFLUIDIC DEVICE FOR RAPID DETECTION OF MYCOBACTERIA." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1093031753.

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11

Nguyen, Vina, and Vina Nguyen. "Microfluidic Paper Analytic Device for Assessment of Blood Coagulation." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/624139.

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Monitoring blood coagulation while a patient is on cardiopulmonary bypass (CPB) is critical in preventing clots from arising in the bypass machine and consequently being sent into the patient’s bloodstream. Current methods used to monitor blood coagulation such as Activated Clotting Time (ACT) yield results that do not correlate coagulation time to heparin or protamine dosage and will typically take at least 400 s to yield a result that is safe to initiate bypass. Microfluidic paper-based analytical devices (μPAD) are advanced sensors based on a wide range of recently developed techniques for

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12

Akinapalli, Srikanth. "MICROFLUIDIC DYNAMIC ISOELECTRIC FOCUSING COUPLED TO MATRIX ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY." OpenSIUC, 2016. https://opensiuc.lib.siu.edu/dissertations/1289.

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Proteomics is an increasingly important area of biological research and has gathered much attention over recent years. Major challenges that make a proteomic analysis difficult are sample complexity, diversity and dynamic range. Progress in the area of proteomics relies heavily on new analytical tools for the sensitive, selective, and high-throughput studies of target analytes. It is estimated that there are several hundred thousand proteins in a human cell. In order to be able to analyze such a complex sample, an analytical method must be capable of separating and detecting many differen

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13

Chen, Yanli. "Single cell analysis on microfluidic devices." Thesis, Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/904.

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14

Lo, Chih-Cheng. "Dna electrophoresis in photopolymerized polyacrylamide gels on a microfluidic device." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2685.

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15

Chowdhury, Ovee Zaman. "Development of digital microfluidic device for dielectrophoretic manipulation of particles." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44635.

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This thesis presents the development of a parallel plate lab-on-a-chip (LOC) device for manipulating biological/surrogate particles in droplet based digital microfluidic (DMF) platforms. A fundamental principle, known as dielectrophoresis (DEP), is used to manipulate the particles in a non-uniform electric field based on their polarizability. DEP can be observed as positive (pDEP) and negative (nDEP), moving particles toward the high and low intensity electric fields, respectively. Binary separation of two particles (Polystyrene beads and E.coli) has been shown on DMF platform by combining pD

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16

Majedy, Motasam. "A microfluidic ultrasonic sample preparation device for bead-based immunoassays." Thesis, KTH, Tillämpad fysik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-152474.

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17

Ullah, Tania. "Development of a microfluidic device for blood oxygenation by photocatalysis." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/50579.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.<br>Includes bibliographical references (p. 85-87).<br>Recent statistics provided by the American Lung Association assert that over 400,000 Americans die every year from lung disorders and more than 35 million are now living with symptoms of lung disease. Mortality rates of heart disease and certain cancers have declined in recent years partly due to improvements in diagnostic testing and the development of targeted medical technologies. Such improvements have not translated over to the treatment of lun

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18

Lin, Tony An-tong. "Vertical hydrodynamic focusing in an isotropically etched glass microfluidic device." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39886.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.<br>Includes bibliographical references (p. 107-109).<br>The development of microfluidic devices has enabled precision control of nanoliter-scale environments and reactions. Vertical hydrodynamic focusing is one possible way to improve the optical performance of these devices while maintaining precision control. Vertical hydrodynamic focusing was studied through the use of computation fluid dynamics (ADINA) and experimental testing. It was found that the nonlinear effects of flow rate and geometry on th

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19

Plevniak, Kimberly. "3D printed microfluidic device for point-of-care anemia diagnosis." Thesis, Kansas State University, 2016. http://hdl.handle.net/2097/32875.

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Master of Science<br>Department of Biological & Agricultural Engineering<br>Mei He<br>Anemia affects about 25% of the world’s population and causes roughly 8% of all disability cases. The development of an affordable point-of-care (POC) device for detecting anemia could be a significant for individuals in underdeveloped countries trying to manage their anemia. The objective of this study was to design and fabricate a 3D printed, low cost microfluidic mixing chip that could be used for the diagnosis of anemia. Microfluidic mixing chips use capillary flow to move fluids without the aid of ex

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20

Adams, Shauna. "Antibody/Cell Binding and Magnetic Transport in a Microfluidic Device." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1372104885.

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21

Simon-Desbois, Linda. "Development of a microfluidic device for single cell transcriptome analysis." Thesis, Lille 2, 2013. http://www.theses.fr/2013LIL2S007.

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L’hétérogénéité cellulaire au sein d’une même population cellulaire a été observée chez des organismes procaryotes, chez des organismes plus complexes tels que les mammifères et chez les cellules cancéreuses. L’expression des gènes est un phénomène stochastique ou « bruité ». La connaissance, à l’échelle d’une cellule isolée, des variations stochastiques de l’expression génique, ses oscillations dans le temps et en fonction des fluctuations extérieures constitue un enjeu majeur. Elle permettrait de connaitre les mécanismes de croissance, de différenciation et de migration cellulaire et par voi

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Flores, Edeliz. "A scalable microfluidic extraorporeal lung assist device for preterm neonates." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12383.

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Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Respiratory distress syndrome is a leading source of morbidity and mortality in preterm infants. The pathophysiology of Respiratory Distress Syndrome (RDS) is centered on decreased lung compliance secondary to i

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23

Greco, Pierpaolo <1977&gt. "Microfluidic device and interfacial transport: application to biomolecules and nanostructures." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1663/1/Pierpaolo_Greco_PhD_thesis.pdf.

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The aim of my dissertation is to provide new knowledge and applications of microfluidics in a variety of problems, from materials science, devices, and biomedicine, where the control on the fluid dynamics and the local concentration of the solutions containing the relevant molecules (either materials, precursors, or biomolecules) is crucial. The control of interfacial phenomena occurring in solutions at dierent length scales is compelling in nanotechnology for devising new sensors, molecular electronics devices, memories. Microfluidic devices were fabricated and integrated with organic electr

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Greco, Pierpaolo <1977&gt. "Microfluidic device and interfacial transport: application to biomolecules and nanostructures." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1663/.

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The aim of my dissertation is to provide new knowledge and applications of microfluidics in a variety of problems, from materials science, devices, and biomedicine, where the control on the fluid dynamics and the local concentration of the solutions containing the relevant molecules (either materials, precursors, or biomolecules) is crucial. The control of interfacial phenomena occurring in solutions at dierent length scales is compelling in nanotechnology for devising new sensors, molecular electronics devices, memories. Microfluidic devices were fabricated and integrated with organic electr

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25

Jin, Chao. "Microfluidic device for continuous deformability based separation of circulating tumor cells." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50109.

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Circulating tumor cells have been implicated as potential seeds of cancer metastasis and have strong prognostic and diagnostic value in cancer therapy. The primary challenge in CTC characterization is their extreme rarity in circulation relative to leukocytes. Conventional strategies employ CTC immunoenrichment that is highly selective but may fail to enrich for CTCs with poor antigen expression. However, CTCs exhibit unique morphological characteristics that distinguish them from leukocytes and deformability-based sorting mechanisms represent a compelling label-free CTC enrichment strategy. O

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Zhang, Bangwei. "Guiding nonmagnetic particles by external magnetic field in a microfluidic device." Thesis, Wichita State University, 2008. http://hdl.handle.net/10057/2100.

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This report presents the fabrication of a micro fluidic device using the UV lithography method in order to separate nonmagnetic fluoresbrite carboxy microspheres from the mixed ferrofluids in microchannels. The microfluidic device is fabricated using a SU8-50 negative photoresist that is exposed to the UV lights with a mask (Y shape) on the top of the photoresist. By applying the external magnet from a side of the microchannel, the fluoresbrite carboxy microspheres and ferrofluids are separated into different channels because of the magnetic force acted on the nonmagnetic spheres. During the f

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27

Lin, Bill Kengli. "Automated microfluidic device for the separation of cancer cells from blood." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43737.

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The ability to separate cells based on biomechanical properties such as size and deformability is emerging as a potential alternative to biochemical methods for cell separation, particularly in cases where biochemical markers are unknown or expressed at low levels. The separation of circulating tumor cells (CTCs) is an example problem where this type of technology is important because the cell surface markers currently used to capture these cells are known to be unreliable. The performance of existing biomechanical cell separation techniques is currently hindered by clogging, which reduces spe

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Leung, Kaston. "A programmable droplet-based microfluidic device for multiparameter single-cell analysis." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/43855.

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29

Phaneuf, Christopher. "Infrared laser-mediated polymerase chain reaction in a polymer microfluidic device." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53068.

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The ability to rapidly, sensitively, and accurately detect the presence of a pathogen is a vital capability for first responders in the assessment and treatment of scenarios such as disease outbreak and bioterrorism. Nucleic acid tests such as the polymerase chain reaction (PCR) are supplanting traditional techniques due to the improved speed, specificity, sensitivity, and simplicity. Still, amplification by PCR is often the bottleneck when processing genetic samples. Conventional PCR machines are bulky, slow, and consume large reagent volumes and an affordable, compact, efficient, easy-to-use

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30

Rhodes, Christopher R. (Christopher Randolph). "Microfluidic flow-focusing device for the electrospinning of hollow polymer nanofibers." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/36290.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2006.<br>Includes bibliographical references (p. 52-53).<br>Polymer nanofibers hold much promise as advanced composite materials, and can be customized into matrices with special electrical, optical and biological properties. Electrospinning, which utilizes the destabilization of a fluid's surface in a strong electric field, has gained the most favor as a top-down approach to producing polymer nanofibers. In this work, a microfluidic device was designed and assembled for the two-dimensional focusing of immis

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Hu, Chunxiao. "Microfluidic electrophysiological device for genetic and chemical biology screening of nematodes." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/368250/.

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Genetic and chemical biology screens of C. elegans have been of enormous benefit in providing fundamental insight into neural function and neuroactive drugs. Recently the exploitation of microfluidic devices has added greater power to this experimental approach providing more discrete and higher throughput phenotypic analysis of neural systems. This repertoire is extended through the design of a semi-automated microfluidic device, NeuroChip, which has been optimised for selecting worms based on the electrophysiological features of the pharyngeal neural network. This device has the capability t

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32

Sanders, Tarra Danielle. "A Protocol for Achieving Adherent Cell Culture within a Microfluidic Device." DigitalCommons@CalPoly, 2020. https://digitalcommons.calpoly.edu/theses/2244.

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The goal of this study is to design a protocol for the adherent cell culture within a novel microfluidic device. Microscale cell culture protocols were developed for loading cells using poly-L-lysine to enhance adherent cell culture of murine derived NIH 3T3 fibroblasts. This work sought to develop a method for adherent microculture by examining various sterilization, surface treatment, and seeding techniques. Using a vacuum suction loading technique, air plasma treatment and a poly-L-lysine surface treatment adherent cell culture was observed within the device. The work presented here is part

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33

Li, Hua. "Qualitative Blood Coagulation Test Using Paper-Based Microfluidic Lateral Flow Device." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1406810864.

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34

Miller, Samuel A. "Electroosmotic Flow Driven Microfluidic Device for Bacteria Isolation Using Magnetic Microbeads." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1544101007184486.

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35

Lamberti, Giuseppina. "A BIOMIMETIC MICROFLUIDIC DEVICE FOR MODELING THE LEUKOCYTE ADHESION/MIGRATION CASCADE." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/265841.

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Mechanical Engineering<br>Ph.D.<br>There is a clear need for testing targeted drug carrier systems in a more realistic microenvironment where both biochemical interactions and shear forces are present. This is critical both for understanding of the molecular mechanisms involved in this process and during the drug discovery process. Current in vitro models of the leukocyte adhesion cascade cannot be used for real-time studies of the entire leukocyte adhesion cascade including rolling, adhesion and migration in a single assay. In this study, we have developed and validated a novel bioinspired mi

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36

Peters, Stewart Monnich Gomez Shawn M. "Design and validation of a microfluidic device for controlled cell stimulation." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1834.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Master of Science in the Department of Biomedical Engineering School of Medicine." Discipline: Biomedical Engineering; Department/School: Medicine.

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37

Zhang, Bangwei Asmatulu Ramazan. "Guiding nonmagnetic particles by external magnetic field in a microfluidic device." A link to full text of this thesis in SOAR, 2008. http://hdl.handle.net/10057/2100.

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Balasubramanian, Ashwin Kumar. "A microfluidic device for continuous capture and concentration of pathogens from water." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1339.

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Dhopeshwarkar, Rahul Rajesh. "Electrokinetic concentration enrichment within a microfluidic device integrated with a hydrogel microplug." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1442.

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40

Madadi, Hojjat. "Analysis and design of a capillary driven blood plasma separation microfluidic device." Doctoral thesis, Universitat Politècnica de Catalunya, 2014. http://hdl.handle.net/10803/353621.

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Recently, the emergence of lab-on-a-chip devices has seen in a variety of applications especially in clinical analys is and diagnostics. ln particular the lack of suitable microdevices for separation of plasma from whole blood is a barrier to achieve a reliable lab on a chip (LOC) blood test. In order to address this issue, a novel self-driven high throughput blood plasma separator microchip is introduced as a first step to a miniaturized blood analys is. PDMS (Polydim ethylsiloxane) is utilized as the base material for the microdevice fabrication to ens ure the biocompatibility, the disposa

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Tulukcuoglu, Güneri Ezgi. "Development of microfluidic device for high content analysis of circulating tumor cells." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066583/document.

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Le cancer est l'une des principales causes de décès dans le monde. D'après la société américaine contre le cancer; en 2015, un quart des décès aux Etats-Unis est du au cancer du poumon avant même les maladies cardiaques. Cette situation nous incite et bien d'autres scientifiques dans le monde à développer des moyens plus efficaces de traitement, le diagnostic et le dépistage de la maladie. Parce que près de 90% des décès par cancer sont dus à des métastases, de nombreuses études se sont concentrées sur le mécanisme de métastases et sur son impact clinique. Les cellules tumorales circulantes (C

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Monette-Catafard, Nicolas. "High-throughput Cell Encapsulation in Monodisperse Agarose Microcapsules Using a Microfluidic Device." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31852.

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Over the last decade, microfluidics has emerged as a distinct new field with promising applications for diverse research areas. The ability to precisely control fluids at the microscale allows the execution of a variety of programmable semi-automatic operations on the same device, effectively forming a lab-on-a-chip. In particular, droplet-based microfluidic systems – which reliably generate highly uniform microdroplets at a high throughput – enable the controlled compartmentalization of biological material and have the potential to influence mainstream biomedical research. In this thesis, a m

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Cencen, Veronika. "A Microfluidic Device for Transfection of Mammalian Cells Using Adjustable Shear Stress." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35525.

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Microfluidic technology is a rapidly progressing tool in biomedical engineering. Microfluidic devices are appreciated for their simplicity and production efficiency potential. Our research focuses on developing a microfluidic device capable of transfecting cells by applying shear stress to cause temporary membrane damage. The advantage of this physical method of transfection is the possibility of incorporating large molecules that cannot be inserted with more traditional chemical transfection methods, while avoiding the large fall in viability seen with other physical methods such as electropo

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Woodward, Andrew James. "Monodisperse emulsions from a microfluidic device : a diffusion NMR and SANS study." Thesis, University of Hertfordshire, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495646.

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In order to study the oil/water interface, model monodisperse emulsions were produced using a microfluidic device. The device contains a series of channels of oil and water, designed to converge so that the aqueous phase imparts sufficient shear on an oil stream to cause it to break and form droplets. Monodisperse emulsions of diameter 15 to 120 μm have been created by varying the aqueous emulsifier concentration, the flow rates of each phase, the channel geometry, and the oil viscosity PFG-NMR echo attenuation curves of the monodisperse emulsions contain modulations attributed to a diffusion-

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Sánchez, Daniela [Verfasser], and A. [Akademischer Betreuer] Guber. "Automated Integrated Microfluidic Device for DNA Cloning / Daniela Sánchez ; Betreuer: A. Guber." Karlsruhe : KIT-Bibliothek, 2019. http://d-nb.info/1184990085/34.

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Bu, Minqiang. "Design and fabrication of a microfluidic device for polymerase chain reaction application." Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423216.

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Super, A. S. M. "Oxygen monitoring in a microfluidic culture device for stem cell bioprocess development." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1458640/.

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In this thesis, an online oxygen monitoring system has been presented to quantify the dissolved oxygen concentration levels in a microfluidic device for the adherent culture of pluripotent stem cells. Oxygen is a critical environmental cue regulating stem cell fate. Therefore an online monitoring system, combined with the greater control over the soluble microenvironment provided by microfluidic systems, is of interest to assist the development of robust bioprocessing approaches for regenerative medicine therapies. An oxygen monitoring system consisting of optical sensors have been designed an

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Huang, Sheng-Kai, and 黃聖凱. "Target Cell Electroporation in Microfluidic Device." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/34314854527398730592.

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碩士<br>國立臺灣大學<br>生物產業機電工程學研究所<br>104<br>One of the key techniques in gene delivery and cell therapy is to break through the limit of the cell membrane and to send gene or drug into the cell. Electroporation is one of such methods. However, it conventionally suffers the drawbacks in high voltage, large sample amount and high heat generation. The gene/drug delivery results can be only estimated for the average gene expression of the group of the cells, instead of a single cell. To realize a particular gene expression onto a single cell, our thesis thus is devoted to perform electroporation on a s

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Yang, Dong-Yu, and 楊東豫. "Microfluidic device for Sulfur dioxide detection." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/36318717434755592118.

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碩士<br>國立屏東科技大學<br>材料工程研究所<br>104<br>A paper-based microfluidic device has been presented to improve the traditional method of sulfur dioxide detection in this study. According to the Acid-base theory, microfluidics, and paper-based chip technology, the filter paper coated with the acid-base indicator was packaged in Polymethyl Methacrylate. As the sample injected into the paper-based microfluidic device, the color of acid-base indicator will be changed in the detecting zone. After the above reaction, an analytical instrument was designed to transfer the color of acid-base indicator as the digi

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Han, Cheng-Chun, and 韓承均. "Microfluidic Device for Multi-sample Dispensing." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/20660281481113352254.

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碩士<br>義守大學<br>機械與自動化工程學系碩士班<br>99<br>The main purpose of this research is fabrication of multiple quantitative micro-sampler using micro-electro-mechanical-system (MEMS) technology. This micro-sampler includes three major components: microfluidic channel, micro-pump/micro-valve and nozzles with different diameters. The applications of micro-system are (1) quantitative droplets by micro-pump pressure control (2) weight of droplets (3) different samples without contamination. Experiment was also conducted by choosing different viscosity of the fluid to observe the change of droplets. This multip

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