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Journal articles on the topic 'Microfluidic device'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Chen, Luyao, Xin Guo, Xidi Sun, et al. "Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review." Micromachines 14, no. 3 (2023): 547. http://dx.doi.org/10.3390/mi14030547.

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Microfluidics has recently received more and more attention in applications such as biomedical, chemical and medicine. With the development of microelectronics technology as well as material science in recent years, microfluidic devices have made great progress. Porous structures as a discontinuous medium in which the special flow phenomena of fluids lead to their potential and special applications in microfluidics offer a unique way to develop completely new microfluidic chips. In this article, we firstly introduce the fabrication methods for porous structures of different materials. Then, th

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Cai, Jianchen, Jiaxi Jiang, Jinyun Jiang, et al. "Fabrication of Transparent and Flexible Digital Microfluidics Devices." Micromachines 13, no. 4 (2022): 498. http://dx.doi.org/10.3390/mi13040498.

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This study proposed a fabrication method for thin, film-based, transparent, and flexible digital microfluidic devices. A series of characterizations were also conducted with the fabricated digital microfluidic devices. For the device fabrication, the electrodes were patterned by laser ablation of 220 nm-thick indium tin oxide (ITO) layer on a 175 μm-thick polyethylene terephthalate (PET) substrate. The electrodes were insulated with a layer of 12 μm-thick polyethylene (PE) film as the dielectric layer, and finally, a surface treatment was conducted on PE film in order to enhance the hydrophobi

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3

Kong, David S., Todd A. Thorsen, Jonathan Babb, et al. "Open-source, community-driven microfluidics with Metafluidics." Nature Biotechnology 35, no. 6 (2017): 523–29. http://dx.doi.org/10.1038/nbt.3873.

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Abstract Microfluidic devices have the potential to automate and miniaturize biological experiments, but open-source sharing of device designs has lagged behind sharing of other resources such as software. Synthetic biologists have used microfluidics for DNA assembly, cell-free expression, and cell culture, but a combination of expense, device complexity, and reliance on custom set-ups hampers their widespread adoption. We present Metafluidics, an open-source, community-driven repository that hosts digital design files, assembly specifications, and open-source software to enable users to build

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Chen, Pin Chuan, and Zhi Ping Wang. "A Rapid and Low Cost Manufacturing for Polymeric Microfluidic Devices." Advanced Materials Research 579 (October 2012): 348–56. http://dx.doi.org/10.4028/www.scientific.net/amr.579.348.

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A rapid manufacturing process was demonstrated to fabricate a microfluidic device to amplify specific DNA fragments in less than 8 hours. Microfluidics was derived from microelectromechanical system (MEMS) with lithography technique on the substrates of silicon and glass, which made the microfluidic product have a higher fabrication cost and laborious fabrication steps. This rapid approach only requires three steps for a PDMS microfluidic device: metal mold insert manufacturing, PDMS casting, and glass bonding. Each step did not require complicated equipments or procedures, and make this appro

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5

Xu, Anlin, and Ping Li. "Microfluidic Device Control System Based on Segmented Temperature Sensor." Mobile Information Systems 2021 (May 18, 2021): 1–11. http://dx.doi.org/10.1155/2021/9930649.

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Microfluidic technology refers to the technique of controlling the flow, mass transfer, and heat transfer of a fluid with a volume of picoliter to nanoliter in a low-dimensional channel structure with at least one dimension of micron or even nanometer scale. It is widely used in biochemical analysis, immunity, minimally invasive surgery, and environmental monitoring. This paper proposes a microfluidic device based on a segmented temperature sensor. This device can be used for segmental temperature measurement and controlling the temperature of the solution in the microchannel of a glass microf

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Prajitna, Stefanus H., Christian Harito, and Brian Yuliarto. "Cost-Effective Manufacturing of Microfluidics Through the Utilization of Direct Ink Writing." Emerging Science Journal 9, no. 1 (2025): 1–11. https://doi.org/10.28991/esj-2025-09-01-01.

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Microfluidics is essential for precise manipulation of fluids in small channels. However, conventional manufacturing processes for microfluidic devices are expensive, time-consuming, and require specialized equipment in a clean room. While recent studies have improved the cost-effectiveness of this device, there is still a need for further advancement in cost efficiency. Therefore, this study aimed to develop a custom-built direct-ink writing (DIW) printer for manufacturing microfluidic devices that is more affordable. Custom-built DIW directly printed microfluidic channels onto microscope sli

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Zhu, Zhiyuan, Fan Zeng, Zhihua Pu, and Jiyu Fan. "Conversion Electrode and Drive Capacitance for Connecting Microfluidic Devices and Triboelectric Nanogenerator." Electronics 12, no. 3 (2023): 522. http://dx.doi.org/10.3390/electronics12030522.

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Microfluidics is a technique that uses channels of tiny sizes to process small amounts of fluid, which can be used in biochemical detection, information technology, and other fields. In the process of microfluidic development, there are many problems that need to be solved urgently. Many microfluidic systems require the support of external devices, which increases the construction cost, and the electronic interface technology is not mature. A triboelectric nanogenerator (TENG) can harvest mechanical energy and turn it into electrical energy. It has been greatly developed now and is widely used

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8

Männel, Max J., Elif Baysak, and Julian Thiele. "Fabrication of Microfluidic Devices for Emulsion Formation by Microstereolithography." Molecules 26, no. 9 (2021): 2817. http://dx.doi.org/10.3390/molecules26092817.

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Droplet microfluidics—the art and science of forming droplets—has been revolutionary for high-throughput screening, directed evolution, single-cell sequencing, and material design. However, traditional fabrication techniques for microfluidic devices suffer from several disadvantages, including multistep processing, expensive facilities, and limited three-dimensional (3D) design flexibility. High-resolution additive manufacturing—and in particular, projection micro-stereolithography (PµSL)—provides a promising path for overcoming these drawbacks. Similar to polydimethylsiloxane-based microfluid

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9

Bogseth, Amanda, Jian Zhou, and Ian Papautsky. "Evaluation of Performance and Tunability of a Co-Flow Inertial Microfluidic Device." Micromachines 11, no. 3 (2020): 287. http://dx.doi.org/10.3390/mi11030287.

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Microfluidics has gained a lot of attention for biological sample separation and purification methods over recent years. From many active and passive microfluidic techniques, inertial microfluidics offers a simple and efficient method to demonstrate various biological applications. One prevalent limitation of this method is its lack of tunability for different applications once the microfluidic devices are fabricated. In this work, we develop and characterize a co-flow inertial microfluidic device that is tunable in multiple ways for adaptation to different application requirements. In particu

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Duan, Kai, Mohamad Orabi, Alexus Warchock, et al. "Monolithically 3D-Printed Microfluidics with Embedded µTesla Pump." Micromachines 14, no. 2 (2023): 237. http://dx.doi.org/10.3390/mi14020237.

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Microfluidics has earned a reputation for providing numerous transformative but disconnected devices and techniques. Active research seeks to address this challenge by integrating microfluidic components, including embedded miniature pumps. However, a significant portion of existing microfluidic integration relies on the time-consuming manual fabrication that introduces device variations. We put forward a framework for solving this disconnect by combining new pumping mechanics and 3D printing to demonstrate several novel, integrated and wirelessly driven microfluidics. First, we characterized

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Trinh, Kieu The Loan, Duc Anh Thai, and Nae Yoon Lee. "Bonding Strategies for Thermoplastics Applicable for Bioanalysis and Diagnostics." Micromachines 13, no. 9 (2022): 1503. http://dx.doi.org/10.3390/mi13091503.

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Microfluidics is a multidisciplinary science that includes physics, chemistry, engineering, and biotechnology. Such microscale systems are receiving growing interest in applications such as analysis, diagnostics, and biomedical research. Thermoplastic polymers have emerged as one of the most attractive materials for microfluidic device fabrication owing to advantages such as being optically transparent, biocompatible, cost-effective, and mass producible. However, thermoplastic bonding is a key challenge for sealing microfluidic devices. Given the wide range of bonding methods, the appropriate

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Ballacchino, Giulia, Edward Weaver, Essyrose Mathew, et al. "Manufacturing of 3D-Printed Microfluidic Devices for the Synthesis of Drug-Loaded Liposomal Formulations." International Journal of Molecular Sciences 22, no. 15 (2021): 8064. http://dx.doi.org/10.3390/ijms22158064.

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Microfluidic technique has emerged as a promising tool for the production of stable and monodispersed nanoparticles (NPs). In particular, this work focuses on liposome production by microfluidics and on factors involved in determining liposome characteristics. Traditional fabrication techniques for microfluidic devices suffer from several disadvantages, such as multistep processing and expensive facilities. Three-dimensional printing (3DP) has been revolutionary for microfluidic device production, boasting facile and low-cost fabrication. In this study, microfluidic devices with innovative mic

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Wang, Xu, Jingtian Zheng, Maheshwar Adiraj Iyer, Adam Henry Szmelter, David T. Eddington, and Steve Seung-Young Lee. "Spatially selective cell treatment and collection for integrative drug testing using hydrodynamic flow focusing and shifting." PLOS ONE 18, no. 1 (2023): e0279102. http://dx.doi.org/10.1371/journal.pone.0279102.

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Hydrodynamic focusing capable of readily producing and controlling laminar flow facilitates drug treatment of cells in existing microfluidic culture devices. However, to expand applications of such devices to multiparameter drug testing, critical limitations in current hydrodynamic focusing microfluidics must be addressed. Here we describe hydrodynamic focusing and shifting as an advanced microfluidics tool for spatially selective drug delivery and integrative cell-based drug testing. We designed and fabricated a co-flow focusing, three-channel microfluidic device with a wide cell culture cham

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14

Arebalo, Raymond J., Augustin J. Sanchez, and Nathan Tompkins. "Same Day Microfluidics: From Design to Device in Under Three Hours." Nanomanufacturing 5, no. 3 (2025): 9. https://doi.org/10.3390/nanomanufacturing5030009.

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Microfluidic devices are used in numerous scientific fields and research areas, but device fabrication is still a time- and resource-intensive process largely confined to the cleanroom or a similarly well-equipped laboratory. This paper presents a method to create microfluidic devices in under three hours using the silicone polymer polydimethylsiloxane (PDMS) and a laser cut positive master using PDMS double casting without a cleanroom or other large capital equipment. This method can be utilized by an undergraduate student with minimal training in a laboratory with a modest budget. This paper

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15

Giri, Kiran, and Chia-Wen Tsao. "Recent Advances in Thermoplastic Microfluidic Bonding." Micromachines 13, no. 3 (2022): 486. http://dx.doi.org/10.3390/mi13030486.

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Microfluidics is a multidisciplinary technology with applications in various fields, such as biomedical, energy, chemicals and environment. Thermoplastic is one of the most prominent materials for polymer microfluidics. Properties such as good mechanical rigidity, organic solvent resistivity, acid/base resistivity, and low water absorbance make thermoplastics suitable for various microfluidic applications. However, bonding of thermoplastics has always been challenging because of a wide range of bonding methods and requirements. This review paper summarizes the current bonding processes being p

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Kurniawan, Yehezkiel Steven, Arif Cahyo Imawan, Sathuluri Ramachandra Rao, et al. "Microfluidics Era in Chemistry Field: A Review." Journal of the Indonesian Chemical Society 2, no. 1 (2019): 7. http://dx.doi.org/10.34311/jics.2019.02.1.7.

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By miniaturizing the reactor dimension, microfluidic devices are attracting world attention and starting the microfluidic era, especially in the chemistry field because they offer great advantages such as rapid processes, small amount of the required reagents, low risk, ease and accurate control, portable and possibility of online monitoring. Because of that, microfluidic devices have been massively investigated and applied for the real application of human life. This review summarizes the up-to-date microfluidic research works including continuous-flow, droplet-based, open-system, paper-based

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Katherine, S. Elvira, and Fabrice Gielen. "Materials and methods for droplet microfluidic device fabrication." Lab on a Chip, no. 22 (October 2, 2024): 859. https://doi.org/10.1039/d1lc00836f.

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Since the first reports two decades ago, droplet-based systems have emerged as a compelling tool for microbiological and (bio)chemical science, with droplet flow providing multiple advantages over standard single-phase microfluidics such as removal of Taylor dispersion, enhanced mixing, isolation of droplet contents from surfaces, and the ability to contain and address individual cells or biomolecules. Typically, a droplet microfluidic device is designed to produce droplets with well-defined sizes and compositions that flow through the device without interacting with channel walls. Successful

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18

You, Jae Bem, Byungjin Lee, Yunho Choi, et al. "Nanoadhesive layer to prevent protein absorption in a poly(dimethylsiloxane) microfluidic device." BioTechniques 69, no. 1 (2020): 46–51. http://dx.doi.org/10.2144/btn-2020-0025.

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Poly(dimethylsiloxane) (PDMS) is widely used as a microfluidics platform material; however, it absorbs various molecules, perturbing specific chemical concentrations in microfluidic channels. We present a simple solution to prevent adsorption into a PDMS microfluidic device. We used a vapor-phase-deposited nanoadhesive layer to seal PDMS microfluidic channels. Absorption of fluorescent molecules into PDMS was efficiently prevented in the nanolayer-treated PDMS device. Importantly, when cultured in a nanolayer-treated PDMS device, yeast cells exhibited the expected concentration-dependent respo

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19

Kim, Hojin, Alexander Zhbanov, and Sung Yang. "Microfluidic Systems for Blood and Blood Cell Characterization." Biosensors 13, no. 1 (2022): 13. http://dx.doi.org/10.3390/bios13010013.

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A laboratory blood test is vital for assessing a patient’s health and disease status. Advances in microfluidic technology have opened the door for on-chip blood analysis. Currently, microfluidic devices can reproduce myriad routine laboratory blood tests. Considerable progress has been made in microfluidic cytometry, blood cell separation, and characterization. Along with the usual clinical parameters, microfluidics makes it possible to determine the physical properties of blood and blood cells. We review recent advances in microfluidic systems for measuring the physical properties and biophys

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20

Tang, Xiaoqing, Qiang Huang, Tatsuo Arai, and Xiaoming Liu. "Cell pairing for biological analysis in microfluidic devices." Biomicrofluidics 16, no. 6 (2022): 061501. http://dx.doi.org/10.1063/5.0095828.

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Cell pairing at the single-cell level usually allows a few cells to contact or seal in a single chamber and provides high-resolution imaging. It is pivotal for biological research, including understanding basic cell functions, creating cancer treatment technologies, developing drugs, and more. Laboratory chips based on microfluidics have been widely used to trap, immobilize, and analyze cells due to their high efficiency, high throughput, and good biocompatibility properties. Cell pairing technology in microfluidic devices provides spatiotemporal research on cellular interactions and a highly

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Wu, Shigang, Xin Wang, Zongwen Li, Shijie Zhang, and Fei Xing. "Recent Advances in the Fabrication and Application of Graphene Microfluidic Sensors." Micromachines 11, no. 12 (2020): 1059. http://dx.doi.org/10.3390/mi11121059.

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This review reports the progress of the recent development of graphene-based microfluidic sensors. The introduction of microfluidics technology provides an important possibility for the advance of graphene biosensor devices for a broad series of applications including clinical diagnosis, biological detection, health, and environment monitoring. Compared with traditional (optical, electrochemical, and biological) sensing systems, the combination of graphene and microfluidics produces many advantages, such as achieving miniaturization, decreasing the response time and consumption of chemicals, i

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Tonooka, Taishi. "Microfluidic Device with an Integrated Freeze-Dried Cell-Free Protein Synthesis System for Small-Volume Biosensing." Micromachines 12, no. 1 (2020): 27. http://dx.doi.org/10.3390/mi12010027.

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Microfluidic devices enable the precise operation of liquid samples in small volumes. This motivates why microfluidic devices have been applied to point-of-care (PoC) liquid biopsy. Among PoC liquid biopsy studies, some report diagnostic reagents being freeze-dried in such microfluidic devices. This type of PoC microfluidic device has distinct advantages, such as simplicity of the procedures, compared with other PoC devices using liquid-type diagnostic reagents. Despite the attractive characteristic, only diagnostic reagents based on the cloned enzyme donor immunoassay (CEDIA) have been freeze

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Nguyen, Duong Thanh, Van Thi Thanh Tran, Huy Trung Nguyen, Hong Thi Cao, Thai Quoc Vu, and Dung Quang Trinh. "Preparation of microfluidics device from PMMA for liposome synthesis." Vietnam Journal of Science and Technology 61, no. 1 (2023): 84–90. http://dx.doi.org/10.15625/2525-2518/16577.

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Microfluidics has emerged in recent years as a technology that has advantages and is well suited for studying chemistry, biology, and physics at the microscale. A common material which has been widely use to fabricate the microfluidic system is thermoplastic materials. The method of fabricating microfluidic devices has been growing because of advantages such as high-quality feature replication, inexpensiveness, and ease of use. However, the major barrier to the utilization of thermoplastics is the lack of bonding methods for different plastic layers to close the microchannels. Therefore, this

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Yuan, Rodger, Jaemyon Lee, Hao-Wei Su, et al. "Microfluidics in structured multimaterial fibers." Proceedings of the National Academy of Sciences 115, no. 46 (2018): E10830—E10838. http://dx.doi.org/10.1073/pnas.1809459115.

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Traditional fabrication techniques for microfluidic devices utilize a planar chip format that possesses limited control over the geometry of and materials placement around microchannel cross-sections. This imposes restrictions on the design of flow fields and external forces (electric, magnetic, piezoelectric, etc.) that can be imposed onto fluids and particles. Here we report a method of fabricating microfluidic channels with complex cross-sections. A scaled-up version of a microchannel is dimensionally reduced through a thermal drawing process, enabling the fabrication of meters-long microfl

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Acosta-Cuevas, José M., Mario A. García-Ramírez, Gabriela Hinojosa-Ventura, Álvaro J. Martínez-Gómez, Víctor H. Pérez-Luna, and Orfil González-Reynoso. "Surface Roughness Analysis of Microchannels Featuring Microfluidic Devices Fabricated by Three Different Materials and Methods." Coatings 13, no. 10 (2023): 1676. http://dx.doi.org/10.3390/coatings13101676.

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In recent years, the utilization of microfluidic devices for precise manipulation of small flows has significantly increased. The effective management of microfluidics is closely associated with microchannel fabrication. The fabrication method employed for microfluidic devices directly impacts the roughness of the microchannels, consequently influencing the flows within them. In this study, the surface roughness of microchannels was investigated through three different fabrication processes: PDMS lithography, PLA printing, and UV resin printing. This research compared and analyzed the surface

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Man, Jia, Luming Man, Chenchen Zhou, et al. "A Facile Single-Phase-Fluid-Driven Bubble Microfluidic Generator for Potential Detection of Viruses Suspended in Air." Biosensors 12, no. 5 (2022): 294. http://dx.doi.org/10.3390/bios12050294.

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Microfluidics devices have widely been employed to prepare monodispersed microbubbles/droplets, which have promising applications in biomedical engineering, biosensor detection, drug delivery, etc. However, the current reported microfluidic devices need to control at least two-phase fluids to make microbubbles/droplets. Additionally, it seems to be difficult to make monodispersed microbubbles from the ambient air using currently reported microfluidic structures. Here, we present a facile approach to making monodispersed microbubbles directly from the ambient air by driving single-phase fluid.

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Kubicki, Wojciech, Aung Thiha, Tymon Janisz, et al. "A 3D printed microfluidic device for centrifugal droplet generation." Rapid Prototyping Journal 30, no. 11 (2024): 357–68. https://doi.org/10.1108/rpj-05-2024-0215.

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Purpose This study aims to use an additive process for the first time to develop a microfluidic device that uses centrifugal technique for precise and repeatable generation of microdroplets. Droplets have versatile applications in life sciences, but so far centrifugal devices for their production have been made mainly using standard subtractive techniques. This study focused on evaluating the applicability of 3D printing technology in the development of centrifugal microfluidic devices and investigating their properties and future applications. Design/methodology/approach First, the background

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Akitsu, Takashiro. "Inversely Finding Peculiar Reaction Conditions toward Microfluidic Droplet Synthesis." Reactions 4, no. 4 (2023): 647–56. http://dx.doi.org/10.3390/reactions4040036.

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With the development of microfluidics, there are increasing reports of syntheses using not only conventional laminar flow at the microscale, but also the dissociation and aggregation of microdroplets. It is known, to some extent, that the microfluidics scale differs from normal scales in terms of the specific surface area, mass diffusion, and heat conduction; these are opposite to those in scale-up in-plant chemical engineering. However, it is not easy to determine what changes when the microdroplet flows through the channel. In this context, the author would like to clarify how the behavior o

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Peytavi, Régis, Frédéric R. Raymond, Dominic Gagné, et al. "Microfluidic Device for Rapid (<15 min) Automated Microarray Hybridization." Clinical Chemistry 51, no. 10 (2005): 1836–44. http://dx.doi.org/10.1373/clinchem.2005.052845.

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Abstract Background: Current hybridization protocols on microarrays are slow and need skilled personnel. Microfluidics is an emerging science that enables the processing of minute volumes of liquids to perform chemical, biochemical, or enzymatic analyzes. The merging of microfluidics and microarray technologies constitutes an elegant solution that will automate and speed up microarray hybridization. Methods: We developed a microfluidic flow cell consisting of a network of chambers and channels molded into a polydimethylsiloxane substrate. The substrate was aligned and reversibly bound to the m

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Saleheen, Amirus, Debalina Acharyya, Rebecca A. Prosser, and Christopher A. Baker. "A microfluidic bubble perfusion device for brain slice culture." Analytical Methods 13, no. 11 (2021): 1364–73. http://dx.doi.org/10.1039/d0ay02291h.

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Shih, Steve C. C., Philip C. Gach, Jess Sustarich, et al. "A droplet-to-digital (D2D) microfluidic device for single cell assays." Lab on a Chip 15, no. 1 (2015): 225–36. http://dx.doi.org/10.1039/c4lc00794h.

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Deng, B., X. F. Li, D. Y. Chen, L. D. You, J. B. Wang, and J. Chen. "Parameter Screening in Microfluidics Based Hydrodynamic Single-Cell Trapping." Scientific World Journal 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/929163.

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Microfluidic cell-based arraying technology is widely used in the field of single-cell analysis. However, among developed devices, there is a compromise between cellular loading efficiencies and trapped cell densities, which deserves further analysis and optimization. To address this issue, the cell trapping efficiency of a microfluidic device with two parallel micro channels interconnected with cellular trapping sites was studied in this paper. By regulating channel inlet and outlet status, the microfluidic trapping structure can mimic key functioning units of previously reported devices. Num

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Li, Qi, Xingchen Zhou, Qian Wang, Wenfang Liu, and Chuanpin Chen. "Microfluidics for COVID-19: From Current Work to Future Perspective." Biosensors 13, no. 2 (2023): 163. http://dx.doi.org/10.3390/bios13020163.

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Spread of coronavirus disease 2019 (COVID-19) has significantly impacted the public health and economic sectors. It is urgently necessary to develop rapid, convenient, and cost-effective point-of-care testing (POCT) technologies for the early diagnosis and control of the plague’s transmission. Developing POCT methods and related devices is critical for achieving point-of-care diagnosis. With the advantages of miniaturization, high throughput, small sample requirements, and low actual consumption, microfluidics is an essential technology for the development of POCT devices. In this review, acco

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Ozcelik, Adem, Sinan Gucluer, and Tugce Keskin. "Continuous Flow Separation of Live and Dead Cells Using Gravity Sedimentation." Micromachines 14, no. 8 (2023): 1570. http://dx.doi.org/10.3390/mi14081570.

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The separation of target cell species is an important step for various biomedical applications ranging from single cell studies to drug testing and cell-based therapies. The purity of cell solutions is critical for therapeutic application. For example, dead cells and debris can negatively affect the efficacy of cell-based therapies. This study presents a cost-effective method for the continuous separation of live and dead cells using a 3D resin-printed microfluidic device. Saccharomyces cerevisiae yeast cells are used for cell separation experiments. Both numerical and experimental studies are

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Zhang, Peiran, Hunter Bachman, Adem Ozcelik, and Tony Jun Huang. "Acoustic Microfluidics." Annual Review of Analytical Chemistry 13, no. 1 (2020): 17–43. http://dx.doi.org/10.1146/annurev-anchem-090919-102205.

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Acoustic microfluidic devices are powerful tools that use sound waves to manipulate micro- or nanoscale objects or fluids in analytical chemistry and biomedicine. Their simple device designs, biocompatible and contactless operation, and label-free nature are all characteristics that make acoustic microfluidic devices ideal platforms for fundamental research, diagnostics, and therapeutics. Herein, we summarize the physical principles underlying acoustic microfluidics and review their applications, with particular emphasis on the manipulation of macromolecules, cells, particles, model organisms,

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Meseguer, Fernando, Carla Giménez Rodríguez, Rocío Rivera Egea, Laura Carrión Sisternas, Jose A. Remohí, and Marcos Meseguer. "Can Microfluidics Improve Sperm Quality? A Prospective Functional Study." Biomedicines 12, no. 5 (2024): 1131. http://dx.doi.org/10.3390/biomedicines12051131.

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The same sperm selection techniques in assisted reproduction clinics have remained largely unchanged despite their weaknesses. Recently, microfluidic devices have emerged as a novel methodology that facilitates the sperm selection process with promising results. A prospective case-control study was conducted in two phases: 100 samples were used to compare the microfluidic device with Density Gradient, and another 100 samples were used to compare the device with the Swim-up. In the initial phase, a significant enhancement in progressive motility, total progressive motile sperm count, vitality,

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Yip, Hon Ming, John C. S. Li, Kai Xie, et al. "Automated Long-Term Monitoring of Parallel Microfluidic Operations Applying a Machine Vision-Assisted Positioning Method." Scientific World Journal 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/608184.

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As microfluidics has been applied extensively in many cell and biochemical applications, monitoring the related processes is an important requirement. In this work, we design and fabricate a high-throughput microfluidic device which contains 32 microchambers to perform automated parallel microfluidic operations and monitoring on an automated stage of a microscope. Images are captured at multiple spots on the device during the operations for monitoring samples in microchambers in parallel; yet the device positions may vary at different time points throughout operations as the device moves back

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Natu, Rucha, Luke Herbertson, Grazziela Sena, Kate Strachan, and Suvajyoti Guha. "A Systematic Analysis of Recent Technology Trends of Microfluidic Medical Devices in the United States." Micromachines 14, no. 7 (2023): 1293. http://dx.doi.org/10.3390/mi14071293.

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In recent years, the U.S. Food and Drug Administration (FDA) has seen an increase in microfluidic medical device submissions, likely stemming from recent advancements in microfluidic technologies. This recent trend has only been enhanced during the COVID-19 pandemic, as microfluidic-based test kits have been used for diagnosis. To better understand the implications of this emerging technology, device submissions to the FDA from 2015 to 2021 containing microfluidic technologies have been systematically reviewed to identify trends in microfluidic medical applications, performance tests, standard

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Perumal, Veeradasan, U. Hashim, and Tijjani Adam. "Mask Design and Simulation: Computer Aided Design for Lab-on-Chip Application." Advanced Materials Research 832 (November 2013): 84–88. http://dx.doi.org/10.4028/www.scientific.net/amr.832.84.

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A simple design and simulation of microwire, contact pad and microfluidic channel on computer aided design (CAD) for chrome mask fabrication are described.The integration of microfluidic and nanotechnology for miniaturized lab-on-chip device has received a large research attention due to its undisputable and widespread biomedical applications. For the development of a micro-total analytical system, the integration of an appropriate fluid delivery system to a biosensing apparatus is required. In this study, we had presented the new Lab-On-Chip design for biomedical application. AutoCAD software

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Md Sahin Ali. "Machine Learning-Based Computational Framework for Microfluidic Device Design and Simulation." Journal of Information Systems Engineering and Management 10, no. 28s (2025): 100–116. https://doi.org/10.52783/jisem.v10i28s.4296.

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To overcome the limits of traditional microfluidic design, this study provides a unique framework that combines machine learning with CFD simulations to expedite development and increase performance. By utilizing Random Forest algorithms, we developed a predictive model that analyzes a vast dataset derived from CFD simulations, capturing the complex fluid behavior within microfluidic systems. The integration of machine learning enables the prediction of key performance metrics, significantly reducing the time and computational resources traditionally required for design optimization. This meth

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Goyal, Garima, Nick Elsbree, Michael Fero, Nathan J. Hillson, and Gregory Linshiz. "Repurposing a microfluidic formulation device for automated DNA construction." PLOS ONE 15, no. 11 (2020): e0242157. http://dx.doi.org/10.1371/journal.pone.0242157.

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Microfluidic applications have expanded greatly over the past decade. For the most part, however, each microfluidics platform is developed with a specific task in mind, rather than as a general-purpose device with a wide-range of functionality. Here, we show how a microfluidic system, originally developed to investigate protein phase behavior, can be modified and repurposed for another application, namely DNA construction. We added new programable controllers to direct the flow of reagents across the chip. We designed the assembly of a combinatorial Golden Gate DNA library using TeselaGen DESI

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Etxebarria-Elezgarai, Jaione, Maite Garcia-Hernando, Lourdes Basabe-Desmonts, and Fernando Benito-Lopez. "Precise Integration of Polymeric Sensing Functional Materials within 3D Printed Microfluidic Devices." Chemosensors 11, no. 4 (2023): 253. http://dx.doi.org/10.3390/chemosensors11040253.

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This work presents a new architecture concept for microfluidic devices, which combines the conventional 3D printing fabrication process with the stable and precise integration of polymeric functional materials in small footprints within the microchannels in well-defined locations. The approach solves the assembly errors that normally occur during the integration of functional and/or sensing materials in hybrid microfluidic devices. The method was demonstrated by embedding four pH-sensitive ionogel microstructures along the main microfluidic channel of a complex 3D printed microfluidic device.

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Catarino, Susana O., Raquel O. Rodrigues, Diana Pinho, João M. Miranda, Graça Minas, and Rui Lima. "Blood Cells Separation and Sorting Techniques of Passive Microfluidic Devices: From Fabrication to Applications." Micromachines 10, no. 9 (2019): 593. http://dx.doi.org/10.3390/mi10090593.

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Since the first microfluidic device was developed more than three decades ago, microfluidics is seen as a technology that exhibits unique features to provide a significant change in the way that modern biology is performed. Blood and blood cells are recognized as important biomarkers of many diseases. Taken advantage of microfluidics assets, changes on blood cell physicochemical properties can be used for fast and accurate clinical diagnosis. In this review, an overview of the microfabrication techniques is given, especially for biomedical applications, as well as a synopsis of some design con

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Islam, Md Nazibul, Jarad Yost, and Zachary Gagnon. "Electrokinetically Assisted Paper-Based DNA Concentration for Enhanced qPCR Sensing." Proceedings 60, no. 1 (2020): 33. http://dx.doi.org/10.3390/iecb2020-07074.

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Paper-based microfluidics have gained widespread attention for use as low-cost microfluidic diagnostic devices in low-resource settings. However, variability in fluid transport due to evaporation and lack of reproducibility with processing real-world samples limits their commercial potential and widespread adoption. We have developed a novel fabrication method to address these challenges. This approach, known as “Microfluidic Pressure in Paper” (μPiP), combines thin laminating polydimethylsiloxane (PDMS) membranes and precision laser-cut paper microfluidic structures to produce devices that ar

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Ota, Nobutoshi, Yaxiaer Yalikun, Tomoyuki Suzuki, et al. "Enhancement in acoustic focusing of micro and nanoparticles by thinning a microfluidic device." Royal Society Open Science 6, no. 2 (2019): 181776. http://dx.doi.org/10.1098/rsos.181776.

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The manipulation of micro/nanoparticles has become increasingly important in biological and industrial fields. As a non-contact method for particle manipulation, acoustic focusing has been applied in sorting, enrichment and analysis of particles with microfluidic devices. Although the frequency and amplitude of acoustic waves and the dimensions of microchannels have been recognized as important parameters for acoustic focusing, the thickness of microfluidic devices has not been considered so far. Here, we report that thin glass microfluidic devices enhance acoustic focusing of micro/nanopartic

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Hong, Yan, Zhihao Xia, Jingming Su, et al. "Multi-Sample Detection of Soil Nitrate Nitrogen Using a Digital Microfluidic Platform." Agriculture 13, no. 12 (2023): 2226. http://dx.doi.org/10.3390/agriculture13122226.

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The rapid quantification of nitrate nitrogen concentration plays a pivotal role in monitoring soil nutrient content. Nevertheless, the low detection efficiency limits the application of traditional methods in rapid testing. For this investigation, we utilized a digital microfluidic platform and 3D-printed microfluidics to accomplish automated detection of soil nitrate nitrogen with high sensitivity across numerous samples. The system combines digital microfluidics (DMF), 3D-printed microfluidics, a peristaltic pump, and a spectrometer. The soil solution, obtained after extraction, was dispense

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Cheon, Jeonghyeon, and Seunghyun Kim. "Fabrication and Demonstration of a 3D-printing/PDMS Integrated Microfluidic Device." Recent Progress in Materials 4, no. 1 (2021): 1. http://dx.doi.org/10.21926/rpm.2201002.

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3D printing is an attractive method to fabricate microfluidic devices due to (1) its fast and simple process without specialized equipment and cleanroom environment, and (2) its capability to create complex 3D structures. Combined with Polydimethylsiloxane (PDMS), it can be used to develop various microfluidic devices taking advantage of both 3D printing and PDMS. In this paper, we investigated a Digital Light Processing (DLP) 3D printer to fabricate 3D printing/PDMS integrated microfluidic devices. We used it to fabricate both a master mold for the PDMS process and a substrate containing pneu

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Ma, Shou-Yu, Yu-Cheng Chiang, Chia-Hsien Hsu, et al. "Peanut Detection Using Droplet Microfluidic Polymerase Chain Reaction Device." Journal of Sensors 2019 (May 2, 2019): 1–9. http://dx.doi.org/10.1155/2019/4712084.

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In this study, we integrated genetic detection for polymerase chain reaction (PCR) with microfluidics technology for the detection of peanut DNA. A cross-junction microchannel was used to induce emulsion droplets of water in oil for PCR on a chip. Compared with the single-phase flow, the emulsion droplet flow exhibited a 7.24% lower evaporation amount and prevented air bubble generation. PCR results of the droplet microfluidic PCR chip for peanut DNA fragment detection was verified by comparison with a commercial PCR thermal cycler and increased fluorescence intensity in SYBR Green reagent-bas

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Testa, Genni, Gianluca Persichetti, and Romeo Bernini. "Planar Optofluidic Integration of Ring Resonator and Microfluidic Channels." Micromachines 13, no. 7 (2022): 1028. http://dx.doi.org/10.3390/mi13071028.

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We report an optofluidic hybrid silicon-polymer planar ring resonator with integrated microfluidic channels for efficient liquid delivery. The device features a planar architecture of intersecting liquid-core waveguides and microfluidic channels. A low-loss integration of microfluidic channels is accomplished by exploiting the interference pattern created by the self-imaging effect in the multimode interference-based coupler waveguides. Numerical simulations have been performed in order to minimize the propagation losses along the ring loop caused by the integration of microfluidic channels. T

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Subirada, Francesc, Roberto Paoli, Jessica Sierra-Agudelo, Anna Lagunas, Romen Rodriguez-Trujillo, and Josep Samitier. "Development of a Custom-Made 3D Printing Protocol with Commercial Resins for Manufacturing Microfluidic Devices." Polymers 14, no. 14 (2022): 2955. http://dx.doi.org/10.3390/polym14142955.

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The combination of microfluidics and photo-polymerization techniques such as stereolithography (SLA) has emerged as a new field which has a lot of potential to influence in such important areas as biological analysis, and chemical detection among others. However, the integration between them is still at an early stage of development. In this article, after analyzing the resolution of a custom SLA 3D printer with commercial resins, microfluidic devices were manufactured using three different approaches. First, printing a mold with the objective of creating a Polydimethylsiloxane (PDMS) replica

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