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Dissertations / Theses on the topic 'Microfluidic method'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Nguyen, Khanh H. (Khanh Huy). "Hot embossing as a method for rapid prototyping microfluidic devices." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/85789.

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Thesis: M. Eng. in Manufacturing, Massachusetts Institute of Technology, Department of Mechanical Engineering, 2013.<br>Title as it appears in Degrees awarded program, September 17, 2003: Design and analysis of a hot embossing machine and the effects of toolware and accuracy of resin replication of high aspect ratio microfluidic features Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 132-135).<br>Hot embossing is a growing technology proven to be capable of reproducing micro-scale features on thermoplastics and can be an effective process for rapid prototyp

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2

Lustrino, Michelle E. (Michelle Elizabeth). "The development of an innovative bonding method for microfluidic applications." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/67622.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2011.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 145-149).<br>The field of microfluidics has powerful applications in low-cost healthcare diagnostics, DNA analysis, and fuel cells, among others. As the field moves towards commercialization, the ability to robustly manufacture these devices at low cost is becoming more important. One of the many challenges in microfluidic manufacturing is the reliable sealing of the microfluidic chips once the channels have been genera

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3

Wu, Jun, and 吴隽. "Drug delivery devices fabricated by microfluidic method and their applications in long-term antimicrobial therapy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/198816.

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Controlled drug delivery devices provide numerous advantages such as reduced side effects, higher therapeutic efficiency and improved patient compliance. Biodegradable polymer has become the most important material for controlled drug delivery device because of the excellent biocompatibility and tunable physicochemical properties. Biodegradable polymeric drug delivery devices are usually processed into various types of micro-particles due to the ease of fabrication and administration. However, controlling the drug release kinetics of these microparticles is still a challenge. One important rea

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4

PENNELLA, FRANCESCO. "Analysis of microscale flows in tissue engineering systems and microfluidic devices." Doctoral thesis, Politecnico di Torino, 2013. http://hdl.handle.net/11583/2514479.

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The doctoral research summarized in this thesis has focused on the study of microflows in Tissue Engineering (TE) scaffolds and microdevices. The thesis is organized in two parts. In the first part, the properties influencing mass transport through scaffold are investigated both experimentally and in silico. In detail: (1) an acoustic measurement system suitable for the evaluation of TE porous scaffolds and based on a single (pressure) transducer is developed; (2) realistic models of irregular porous scaffolds were reconstructed from micro-CT images and fluid transport through them is simulate

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5

Jeon, Jessie Sungyun. "3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/61871.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 48-51).<br>A microfluidic system has been developed for studying the factors inducing different responses of cells in vascular system using a three-dimensional microenvironment. The devices have been transferred from PDMS to a platform in cyclic olefin copolymer (COC) which has advantages in terms of hydrophobicity, production by the more commercially-viable hot embossing technique, and amenability to surface treatments

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6

Winer, Michael Hubert. "A three-dimensional (3D) defocusing-based particle tracking method and applications to inertial focusing in microfluidic devices." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50194.

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Three-dimensional analysis of particles in flows within microfluidic devices is a necessary technique in the majority of current microfluidics research. One method that allows for accurate determination of particle positions in channels is defocusing-based optical detection. This thesis investigates the use of the defocusing method for particles ranging in size from 2-18 μm without the use of a three-hole aperture. Using a calibration-based analysis motivated by previous work, we were able to relate the particle position in space to its apparent size in an image. This defocusing method was the

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7

Othman, Rahimah. "Production of functional pharmaceutical nano/micro-particles by solvent displacement method using advanced micro-engineered dispersion devices." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/22905.

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The rapid advancement of drug delivery systems (DDS) has raised the possibility of using functional engineered nano/micro-particles as drug carriers for the administration of active pharmaceutical ingredients (APIs) to the affected area. The major goals in designing these functional particles are to control the particle size, the surface properties and the pharmacologically active agents release in order to achieve the site-specification of the drug at the therapeutically optimal rate and dose regimen. Two different equipment (i.e. glass capillary microfluidic device and micro-engineered membr

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8

Murali, Divya. "A Sampling Method for the Reduction of Power Consumption in Battery Operated UHF Receivers." University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1220634056.

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9

Duford, David. "Instrumentation, fabrication techniques and method development for sample introduction, preparation and extraction on centrifugal microfluidic devices in motion." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110441.

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A growing number of pollutants are being shown to have a large environmental and health impact resulting in stricter legislative limits. Increased environmental monitoring is forcing analytical chemists to consider automating and miniaturizing current standard methods. Instrumentation and sample handling techniques for centrifugal microfluidic devices in motion have been developed with the objective of integrating multi-step reactions into a single device for the analysis of environmental solid samples.In order to study and optimize centrifugal microfluidic devices in motion, motorized stage

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10

Kim, Ho Jun. "Theoretical and numerical studies of chaotic mixing." Diss., Texas A&M University, 2008. http://hdl.handle.net/1969.1/85940.

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Theoretical and numerical studies of chaotic mixing are performed to circumvent the difficulties of efficient mixing, which come from the lack of turbulence in microfluidic devices. In order to carry out efficient and accurate parametric studies and to identify a fully chaotic state, a spectral element algorithm for solution of the incompressible Navier-Stokes and species transport equations is developed. Using Taylor series expansions in time marching, the new algorithm employs an algebraic factorization scheme on multi-dimensional staggered spectral element grids, and extends classical confo

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11

Lafferty, William Henry. "DEVELOPMENT OF A HIGH PRECISION QUANTUM DOT SYNTHESIS METHOD UTILIZING A MICROFLUIDIC REACTOR AND IN-LINE FLUORESCENCE FLOW CELL." DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1317.

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Quantum dots show great potential for use as spectral converters in solar cells, lighting applications, and biological imaging. These applications require precise control of quantum dot size to maximize performance. The quality, size, and fluorescence of quantum dots depend on parameters that are difficult to control using traditional batch synthesis processes. An alternative, high precision process was developed for the synthesis of cadmium-selenide quantum dots using a microfluidic reactor and fluorescence flow cell. The process required creating separate cadmium and selenium precursors that

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12

Stewart-James, Samantha Ann. "Development of a microfluidic flow cytometry platform with fluorescence and light scattering detection for the rapid characterization of circulating tumor cells." Thesis, Kansas State University, 2015. http://hdl.handle.net/2097/19078.

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Master of Science<br>Department of Chemistry<br>Christopher T. Culbertson<br>Circulating tumor cells (CTCs) have become a key component in the identification and treatment of cancer. Once dislodged from the main tumor, CTCs travel through the bloodstream and cause metastasis. Early detection and identification of these cells can help in the evaluation and prognosis of various types of cancer, as well as assisting in patient treatments by determining the spread of the disease. Here, a high-throughput microfluidic analysis technique is described that can efficiently detect and identify cells,

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13

Banerjee, Ansuman. "A polarization isolation method for measurement of fluorescence assays in a microfluidic system using organic electronics for application to point-of-care diagnostics." Cincinnati, Ohio : University of Cincinnati, 2008. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1218238821.

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Thesis (Ph.D.)--University of Cincinnati, 2008.<br>Advisor: David Klotzkin (Committee Chair), Ian Papautsky (Committee Member), Marc Cahay (Committee Member), Fred Beyette (Committee Member), Paul Bishop (Committee Member). Title from electronic thesis title page (viewed Jan. 18, 2009). Keywords: OLED; OPD; microfluidic; lab-on-a-chip; on-chip fluorescence detector; MEMS; thin films; organic electronics. Includes abstract. Includes bibliographical references.

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14

Guglielmino, Maud. "Développement d'une nouvelle méthode analytique du formaldéhyde dans l'air basée sur un dispositif microfluidique." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAF048.

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Le formaldéhyde (HCHO) est un polluant majeur de l’air intérieur. L’objectif de cette thèse est de réaliser les avancées scientifiques et technologiques nécessaires à l’obtention d’une méthode analytique basée sur un dispositif microfluidique de mesure du formaldéhyde dans l’air associant précision, sélectivité, rapidité d’analyse avec pour objectif majeur une autonomie suffisante sur de longues durées, typiquement un mois. Le principe de la méthode reposait initialement sur trois étapes clés, à savoir le piégeage du formaldéhyde gazeux en solution, la réaction du formaldéhyde avec un agent dé

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15

Hartmann, Michael. "Microfluidic Methods for Protein Microarrays." Doctoral thesis, KTH, Analytisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-26083.

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Protein microarray technology has an enormous potential for in vitro diagnostics (IVD)1. Miniaturized and parallelized immunoassays are powerful tools to measure dozens of parameters from minute amounts of sample, whilst only requiring small amounts of reagent. Protein microarrays have become well-established research tools in basic and applied research and the first diagnostic products are already released on the market. However, in order for protein microarrays to become broadly accepted tools in IVD, a number of criteria have to be fulfilled concerning robustness and automation. Robustness

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16

Zhang, Yingbo. "Microfluidic methods for biomolecular analysis." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274931.

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Microfluidics is the science and technology of manipulating fluids at small scales ranging from microlitres (10$^{-6}$) to picolitres (10$^{-12}$). The fundamental physics is distinct from fluid behaviour on bulk scales and laminar flow is the key characteristic on this scale. Microfluidic systems have a wide range of applications in many disciplines from engineering to physics, chemistry and biotechnology. In this thesis, I explore different strategies exploiting the capabilities of microfluidic devices for manipulating and analysing biomolecules. A particular focus of the work is on the stud

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af, Klinteberg Ludvig. "Computational methods for microfluidics." Licentiate thesis, KTH, Numerisk analys, NA, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-116384.

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This thesis is concerned with computational methods for fluid flows on the microscale, also known as microfluidics. This is motivated by current research in biological physics and miniaturization technology, where there is a need to understand complex flows involving microscale structures. Numerical simulations are an important tool for doing this. The first paper of the thesis presents a numerical method for simulating multiphase flows involving insoluble surfactants and moving contact lines. The method is based on an explicit interface tracking method, wherein the interface between two fluid

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18

Herling, Therese Windelborg. "Microfluidic methods for quantitative protein studies." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709392.

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Ashok, Praveen Cheriyan. "Integration methods for enhanced trapping and spectroscopy in optofluidics." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2546.

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“Lab on a Chip” technologies have revolutionized the field of bio-chemical analytics. The crucial role of optical techniques in this revolution resulted in the emergence of a field by itself, which is popularly termed as “optofluidics”. The miniaturization and integration of the optical parts in the majority of optofluidic devices however still remains a technical challenge. The works described in this thesis focuses on developing integration methods to combine various optical techniques with microfluidics in an alignment-free geometry, which could lead to the development of portable analytica

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20

Klauber, Kameron L. "Rapid prototyping method for a microfluidics device." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/74446.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 12).<br>The product design process can be described as a number of steps taken to turn an idea into a reality. One particular design process of creating a microfluidics device was studied and analyzed. A device containing channels for fluid flow presents a number of challenges for designers. The particular device in this study had a number of specifications, which include a small scale, a necessity to hold fluid, and a

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Russom, Aman. "Microfluidic bead-based methods for DNA analysis." Doctoral thesis, KTH, Skolan för elektro- och systemteknik (EES), 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-155.

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With the completion of the human genome sequencing project, attention is currently shifting toward understanding how genetic variation, such as single nucleotide polymorphism (SNP), leads to disease. To identify, understand, and control biological mechanisms of living organisms, the enormous amounts of accumulated sequence information must be coupled to faster, cheaper, and more powerful technologies for DNA, RNA, and protein analysis. One approach is the miniaturization of analytical methods through the application of microfluidics, which involves the manipulation of fluids in micrometer-size

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22

Chawan, Aschvin Bhagirath. "Novel methods for microfluidic mixing and control." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/54016.

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Microfluidics is a constantly evolving area of research. The implementation of new technologies and fabrication processes offers novel methodologies to solve existing problems. There are currently a large number of established techniques to address issues associated with microscale mixing and valving. We present mixing and valving techniques that utilize simplified and inexpensive techniques. The first technique addresses issues associated with microscale mixing. Exercising control over animal locomotion is well known in the macro world but in the micro-scale world, control requires more soph

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Ung, Warren Lloyd. "Microfluidic Methods for High-Throughput Biological Screening." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845504.

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Often in biology, rare individuals within a population dominate the population’s overall behavior, and we wish to extract those individuals for further analysis. We design a sorting instrument as a flexible platform for the development of novel microfluidic sorting techniques. We demonstrate a microfluidic cell sorter, which screens cells at rates approaching those of commercially-available fluorescence-activated cell sorters. This device incorporates a three-dimensional flow-focusing nozzle with a slanted ceiling groove to enhance the capabilities of a surface acoustic wave (SAW) transduce

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Rossetto, Nicola. "Materials and methods for modular microfluidic devices." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3422583.

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This thesis work concerns the investigation of materials and methods that can be applied to the realization of microfluidic devices (MFDs). In particular, the attention is placed on modular MFDs, as opposed to fully integrated ones. The reasons behind this choice are given in detail in Section 1.2 of this work, but they can be here summarized in the fact that while integrated MFDs offer great advantages in terms of portability, modular devices are more versatile, and so particularly well suited for research applications. The first part of the work here reported describes the microfabrication

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Mukhitov, Nikita. "Microfluidic Methods for the Study of Biological Dynamics." Thesis, The Florida State University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10633959.

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<p>The work in this dissertation presents microfluidic methods developed for the study of biological dynamics. The requirements for the methods development was to create approaches with the ability to perform dynamic cell stimulation, measurement, and sample preparation. The methods presented herein were initially developed for the study of pancreatic islet biology but are expected to be translatable to other applications. In another study, a method to interface transmission electron microscopy (TEM) with microfluidics methods was developed. </p><p> The primary biological topic of interest i

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Morthomas, Julien. "Intéractions hydrodynamiques entre colloïdess confinés le long d'une paroi." Thesis, Bordeaux 1, 2009. http://www.theses.fr/2009BOR13882/document.

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Appliquer un champ électrique ou un gradient de température à une solution colloïdale implique la migration des particules (soluté) en suspension. Ce déplacement n’est pas la conséquence de forces de volume comme dans le cas de la sédimentation mais de forces interfaciales agissant sur la double couche électrique présente à la surface des particules colloïdales chargées. Ces forces induisent un écoulement de surface qui à son tour engendre un champ de vitesse du fluide en 1/r³ autour des particules dans la direction opposée à leurs déplacements, où r distance au centre des particules. Dans ce

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White, Celesta E. "Advanced Methods, Materials, and Devices for Microfluidics." Diss., Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/5287.

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Advanced Methods, Materials, and Devices for Microfluidics Celesta E. White 217 Pages Directed by Dr. Clifford L. Henderson Microfluidics is a rapidly growing research area that has the potential to influence a variety of industries from clinical diagnostics to drug discovery. Unlike the microelectronics industry, where the current emphasis is on reducing the size of transistors, the field of microfluidics is focusing on making more complex systems of channels with more sophisticated fluid-handling capabilities, rather than reducing the size of the channels. While lab-on-a-chip devices have

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Visitkul, Viput. "Novel method for high throughput FRET screening with microfluidics." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/novel-method-for-high-throughput-fret-screening-with-micro-uidics(f5b7a493-ff9c-42d0-889d-3f773591a97e).html.

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Functional imaging can provide a level of quantification that is not possible in what might be termed traditional high-content screening. This is due to the fact that the current state-of-the-art high-content screening systems take the approach of scaling-up single cell assays, and are therefore based on essentially pictorial measures as assay indicators. Such phenotypic analyses have become extremely sophisticated, advancing screening enormously, but this approach can still be somewhat subjective. Recent advances in high-content screening with functional read-outs such as FRET (by FLIM or ani

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Kilimnik, Alexander. "Cross stream migration of compliant capsules in microfluidic channels." Thesis, Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/43669.

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An understanding of the motion of soft capsules in microchannels is useful for a number applications. This knowledge can be used to develop devices to sort biological cells based on their size and stiffness. For example, cancer cells have a different stiffness from healthy cells and thus can be readily identified. Additionally, devices can be developed to detect flaws in synthetic particles. Using a 3D hybrid lattice Boltzmann and lattice spring method, the motion of rigid and soft capsules in a pressure-driven microfluidic flow was probed. The effect of inertial drift is evaluated in channels

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Coquinco, Bernard. "Alternative replica molding methods for polymer based microfluidic channels." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50190.

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Microfluidics provides an opportunity to create low cost devices that can potentially contain many elements of a diagnostics lab on a single chip. While the cost of the finished product may be low, a common method of fabricating microfluidic devices such as soft lithography can be expensive to prototype due to the use of photolithography equipment meant for the semiconductor industry. In addition, the majority of microfluidic research has been done using rectangular channels but in some cases the ability to make circular cross-section channel microfluidic devices would be very useful. For a

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Belotti, Yuri. "Microfluidic methods for investigating cell migration and cell mechanics." Thesis, University of Dundee, 2016. https://discovery.dundee.ac.uk/en/studentTheses/fb5ac03d-a752-45a1-8b95-37c8180dc7d9.

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In this thesis I explore how migratory properties of the model organism Dictyostelium discoideum are influenced by dimensionality and topology of the environment that surrounds the cell. Additionally, I sought to develop a microfluidic device able to measure mechanical properties of single cells with a sufficient throughput to account for the inherent heterogeneity of biological samples. Throughout this thesis I made use of microfabrication methods such as photo-lithography and soft-lithography, to develop ad hoc microstructured substrates. These tools enabled me to tackle different biological

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Rose, Klint A. "Microfluidic manipulation and detection methods for metal microbarcode particles /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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Teo, Adrian J. "Active Droplet Control and Manipulation in Microfluidics." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/392033.

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Droplet microfluidics involves the use of small volumes of fluids dispersed in an immiscible phase to perform multiple functions. Droplet microfluidics brings advantages such as the miniaturization of experiments, portability of devices, efficient use of resources and capabilities for scaling up production. These tools have been finding their use in a broad range of applications, from chemical and biological analysis to optics and information technology. Various types of controls have been developed to enable the manipulation of droplets. These techniques are categorized into passive and activ

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Carlborg, Carl Fredrik. "Development of materials, surfaces and manufacturing methods for microfluidic applications." Doctoral thesis, KTH, Mikrosystemteknik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-38605.

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This thesis presents technological advancements in microfluidics. The overall goals of the work are to develop new miniaturized tests for point-of-care diagnostics and robust super-lubricating surfaces for friction reduction. To achieve these goals, novel materials, surfaces and manufacturing methods in microfluidics have been developed. Point-of-care diagnostic tests are portable miniaturized instruments that downscale and automate medical tests previously performed in the central laboratories of hospitals. The instruments are used in the doctor’s office, in the emergency room or at home as s

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Salem, Mohamed Yafia Okba. "Enhanced actuation and fabrication methods for integrated digital microfluidic systems." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/60456.

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Introducing a practical digital microfluidic (DMF) platform has been always an important goal that can facilitate and broaden the use of DMF systems in various applications on a regular basis. In particular, a desired DMF platform may be the one which is fabricated easily and is also affordable, portable, battery powered, and user friendly. It should perform DMF operations reliably, accept mass-produced replaceable chips and can be readily integrated into a post processing station as well. Accordingly, the development of a practical DMF platform with these characteristics is the main target of

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Klepáčová, Ivana. "Detekce biomarkerů pomocí elektrochemických metod mikrofluidickým čipem." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-317012.

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The thesis is focused on the development of the electrochemical system with microfluidic platform for the detection of multiple biomarkers. It analyses the use of biomarkers for the early diagnosis of cancer. The theoretical part contains basic information about voltammetric methods and microfluidic systems. The practical part provides solutions to the microfluidic chips, including the description of the used materials, designs, methodologies of preparation and conclusions from the testing of the manufactured microfluidic systems. The thesis describes the lock-in electrochemical system which m

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Dawson, Amy. "Paper microfluidics for clinical diagnostics using colourimetric detection methods." Thesis, University of Hull, 2014. http://hydra.hull.ac.uk/resources/hull:10515.

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Microfluidics is a technology currently aiming to advance the medical devices currently available in the developing and developed world through simultaneously creating point-of-care devices which are “as good” or better than current methods at a cheaper production cost. To be able to diagnose diseases and infections quickly and affordably remains the aim of many researchers and the use microfluidics has advantages which plug this difficulty. However, one main gap in the research is to train users for these devices which give accurate results when compared to current methods. Described herein a

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af, Klinteberg Ludvig. "Fast and accurate integral equation methods with applications in microfluidics." Doctoral thesis, KTH, Numerisk analys, NA, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-185758.

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This thesis is concerned with computational methods for fluid flows on the microscale, also known as microfluidics. This is motivated by current research in biological physics and miniaturization technology, where there is a need to understand complex flows involving microscale structures. Numerical simulations are an important tool for doing this. The first, and smaller, part of the thesis presents a numerical method for simulating multiphase flows involving insoluble surfactants and moving contact lines. The method is based on an interface decomposition resulting in local, Eulerian grid repr

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Lu, Chunmeng. "Development of novel micro-embossing methods and microfluidic designs for biomedical applications." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1156820643.

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With, Sebastian [Verfasser]. "Microfluidics as a method to follow dynamic assembly of colloidal systems / Sebastian With." München : Verlag Dr. Hut, 2015. http://d-nb.info/1075409209/34.

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Sun, Xinyu. "Fault Modeling and Fault Type Distinguishing Test Methods for Digital Microfluidics Chips." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380557053.

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Fidalgo, Luis Miguel. "Novel methods for droplet fusion, extraction and analysis in multiphase microfluidics." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611619.

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Moon, Jiyoung. "Rheological Behavior of Complex Fluid with Deformable and Rigid Particles." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17106.

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Predicting the rheological properties of particles in matrix is one of the most challenging and complicated problems in material and fluid sciences. The complication is arisen by the particles collision and interactions with the surrounding fluid. A full description of the rheology of particles requires a complete understanding of the interactions between particles, interaction between the particles and the matrix fluid, and interactions between channel and particles. Thus consideration of above factors can lead to a better understanding of the rheological behavior of suspensions with particle

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Shah, Kumar. "Quantitative Analysis of Tobacco Specific Nitrosamine in Human Urine Using Molecularly Imprinted Polymers as a Potential Tool for Cancer Risk Assessment." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1954.

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Measuring urinary tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronide conjugate may provide the best biomarker of tobacco smoke lung carcinogen metabolism. Existence of differences in the extent of NNAL metabolism rates may be potentially related to an individuals’ lung cancer susceptibility. Low concentrations of NNAL in smokers urine (<1 ng/mL) require sensitive and selective methods for analysis. Traditionally, this involves extensive, time-consuming sample preparation that limits throughput and adds to measurement variability. Molecularly i

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Tran, Thi Thuy. "Compact-disc microfluidic methods for characterization of therapeutic antibodies : Analysis of post-translational modifications." Doctoral thesis, Stockholms universitet, Institutionen för analytisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-83355.

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Characterization of post-translational modifications (PTMs) of therapeutic proteins is very important during the bioprocess development to maintain desired product quality and during the submission process to regulatory authorities for product approval. Monitoring glycosylation in pharmacokinetic studies can be useful to evaluate the dependence of clearance rates on different glycoforms. The cost and efficiency of characterization affect the speed to market of biopharmaceutical proteins. A reduction in the number of manual processing steps, cost of reagents and consumption of sample, as well a

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Fiabane, Joe. "A novel method of producing microbubbles for targeted drug delivery." Thesis, Robert Gordon University, 2016. http://hdl.handle.net/10059/1579.

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Microbubbles, currently employed in diagnostic ultrasound as a contrast agent, have a potential new application as vehicles for targeted drug delivery, which could revolutionise medicine by eliminating side-effects. A new device is developed which outperforms all existing devices in terms of minimum microbubble size:channel diameter ratio. A numerical model is established to describe the flow behaviour and it is determined that the flow regime and resulting microbubble size are dependent on the ratio of inner- to outer Weber number.

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Tartagni, Ottavia <1992&gt. "Advanced cell culture platforms: methods for drug testing with microfluidics and microstructured devices." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amsdottorato.unibo.it/10234/1/Tartagni_Ottavia_Advanced%20cell%20culture%20platforms%20methods%20for%20drug%20testing.pdf.

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Advanced cell cultures are developing rapidly in biomedical research. Nowadays, various approaches and technologies are being used, however, these culturing systems present limitations from increasing complexity, requiring high costs, and not easily customization. We present two versatile and cost-effective methods for developing culturing systems that integrate 3D cell culture and microfluidic platforms. Firstly, for drug screening applications, many high-quality cell spheres of homogeneous size and shape are required. Conventional approaches usually have a dearth of control over the size and

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Rua, Gonzalez Diego. "Synthèse de matériaux catalytiques de type oxydes mixtes pour la production de méthanol par la précipitation en flux continu en système microfluidique." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAF001.

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Le réchauffement climatique est une préoccupation pour les générations actuelles et futures en raison de l'augmentation des émissions de gaz à effet de serre (GES) dans l'atmosphère, principalement dues à la dépendance aux combustibles fossiles. L'utilisation de carburants alternatifs tels que le méthanol durable produit à partir de H2 renouvelable et de CO2 contribuerait à réduire les émissions de GES et les effets du changement climatique. La synthèse du méthanol à partir de matières premières riches en CO2 se fait préférentiellement en utilisant un catalyseur solide composé de CuO, ZnO et Z

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Steiner, Thomas. "Dissipative particle dynamics simulation of microfluidic systems with fluid particle methods on high performance computers." Aachen Shaker, 2009. http://d-nb.info/995271100/04.

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Alabi, Oluwarotimi Ocilama. "The development of microfluidic and surface enhanced Raman methods for petroleum analysis : asphaltene and naphthenic acids." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228647.

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Microfluidic H-cells and surface enhanced Raman spectroscopy are capable of analysing the asphaltene content of petroleum. An H-cell is a microfluidic device that exploits the non-turbulent flow of fluids within a micrometre-dimensioned channel. Diffusive separation in an H-cell permits a liquid that is miscible with the sample matrix to be used as an extractant. It was demonstrated that n-hexane can be used as extractant to obtain an asphaltene-free fraction of oil. The difference between the UV-Vis adsorption spectra of the asphaltene-free oil and the oil sample can then be used to estimate

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