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Relevant bibliographies by topics / Microfluidics. Fluidic devices. Mixing

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Academic literature on the topic 'Microfluidics. Fluidic devices. Mixing'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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Journal articles on the topic "Microfluidics. Fluidic devices. Mixing"

1

Grimmer, Andreas, Philipp Frank, Philipp Ebner, Sebastian Häfner, Andreas Richter, and Robert Wille. "Meander Designer: Automatically Generating Meander Channel Designs." Micromachines 9, no. 12 (November 27, 2018): 625. http://dx.doi.org/10.3390/mi9120625.

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Microfluidics continues to bring innovation to the life sciences. It stimulates progress by enabling new ways of research in biology, chemistry, and biotechnology. However, when designing a microfluidic device, designers have to conduct many tasks by hand—resulting in labor-intensive processes. In particular, when drawing the design of the device, designers have to handle re-occurring entities. Meander channels are one example, which are frequently used in different platforms but always have to fit the respective application and design rules. This work presents an online tool which is capable of automatically generating user-defined, two-dimensional designs of fluidic meander channels facilitating fluidic hydrodynamic resistances. The tool implements specific design rules as it considers the user’s needs and fabrication requirements. The compliance of the meanders generated by the proposed tool is confirmed by fabricating the generated designs and comparing whether the resulting devices indeed realize the desired specification. To this end, two case studies are considered: first, the realization of dedicated fluidic resistances and, second, the realization of dedicated mixing ratios of fluids. The results demonstrate the versatility of the tool regarding application and technology. Overall, the freely accessible tool with its flexibility and simplicity renders manual drawing of meanders obsolete and, hence, allows for a faster, more straightforward design process.

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Wu, J. W., H. M. Xia, Y. Y. Zhang, and P. Zhu. "Microfluidic mixing through oscillatory transverse perturbations." Modern Physics Letters B 32, no. 12n13 (May 10, 2018): 1840030. http://dx.doi.org/10.1142/s0217984918400304.

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Fluid mixing in miniaturized fluidic devices is a challenging task. In this work, the mixing enhancement through oscillatory transverse perturbations coupling with divergent circular chambers is studied. To simplify the design, an autonomous microfluidic oscillator is used to produce the oscillatory flow. It is then applied to four side-channels that intersect with a central channel of constant flow. The mixing performance is tested at high fluid viscosities of up to 16 cP. Results show that the oscillatory flow can cause strong transverse perturbations which effectively enhance the mixing. The influence of a fluidic capacitor in the central channel is also examined, which at low viscosities can intensify the perturbations and further improve the mixing.

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Su, Liang Yao, Yue Yang, and Zhong Bin Xu. "Numerical Simulation of Micromixing with Isolate Bubbles in Microfluidic Flow-Focusing Devices." Advanced Materials Research 781-784 (September 2013): 2876–80. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.2876.

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Microbubbles play an important role in the micromixing of micro-fluidic systems. However, there are few results in the literature about the mixing of the liquids caused by bubbles flow. The paper presents the numerical simulation of bubbles flow in microfluidic, which agrees well with the experimental results. The influence of velocity amplitude, frequency and phase difference on the mixing performance was investigated. The results show that the isolate bubbles as obstruction can improve mixing efficiency in the true straight microchannel, the bigger the velocity amplitude, and the higher the frequency, the better the mixing efficiency is, but the mixing efficiency has nothing to do with the number of bubbles and just benefit from the certain phase difference. With the other two parameter remains unchanged, the mixing performance achieves the best value when the velocity amplitude is 0.25m/s, the frequency is 25HZ, the phase difference is 0.25, respectively. The study referring to bubbles flow induced mixing performance is very important for many microfluidic devices.

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Boutiette, Amber L., Cristoffer Toothaker, Bailey Corless, Chouaib Boukaftane, and Caitlin Howell. "3D printing direct to industrial roll-to-roll casting for fast prototyping of scalable microfluidic systems." PLOS ONE 15, no. 12 (December 28, 2020): e0244324. http://dx.doi.org/10.1371/journal.pone.0244324.

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Microfluidic technologies have enormous potential to offer breakthrough solutions across a wide range of applications. However, the rate of scale-up and commercialization of these technologies has lagged significantly behind promising breakthrough developments in the lab, due at least in part to the problems presented by transitioning from benchtop fabrication methods to mass-manufacturing. In this work, we develop and validate a method to create functional microfluidic prototype devices using 3D printed masters in an industrial-scale roll-to-roll continuous casting process. There were no significant difference in mixing performance between the roll-to-roll cast devices and the PDMS controls in fluidic mixing tests. Furthermore, the casting process provided information on the suitability of the prototype microfluidic patterns for scale-up. This work represents an important step in the realization of high-volume prototyping and manufacturing of microfluidic patterns for use across a broad range of applications.

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Yuen, Po Ki, Guangshan Li, Yijia Bao, and Uwe R. Müller. "Microfluidic devices for fluidic circulation and mixing improve hybridization signal intensity on DNA arrays." Lab Chip 3, no. 1 (2003): 46–50. http://dx.doi.org/10.1039/b210274a.

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Yao, Ping, Ronghui Wang, Xinge Xi, Yanbin Li, and Steve Tung. "3D-Printed Pneumatic Microfluidic Mixer for Colorimetric Detection of Listeria monocytogenes." Transactions of the ASABE 62, no. 3 (2019): 841–50. http://dx.doi.org/10.13031/trans.13245.

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Abstract. 3D printing can significantly improve the current fabrication techniques for microfluidic devices due to its ability to create truly 3D structures in a single step. In this study, an active pneumatic microfluidic mixer was designed and fabricated using an extrusion-based 3D printer and used for rapid detection of . The printed material of the mixer is flexible, semi-transparent, and inexpensive. The fabrication time is significantly shorter than the traditional micromolding process. The printed mixer consists of two pneumatic air chambers and one mixing chamber designed for a fluidic sample size of 100 µL. The length, width, and height of the mixer chip are 13, 12.7, and 9 mm, respectively. The performance of the mixer was tested for different actuation frequencies and pneumatic pressures. The completed 3D-printed mixer was successfully applied to the colorimetric detection of for a concentration range from 102 to 108 cfu mL-1 using an enzyme-linked immunosorbent assay. The experimental results showed that the microfluidic mixer could enhance the mixing efficiency of the fluidic sample through pneumatically actuated diaphragms. In addition, the mixer could accelerate the color development caused by target , and the observed color changes could be discriminated within 5 min by naked eye. The present work will contribute to the development and optimization of a prototype for rapid detection of in food samples. It provides an effective technical approach to realize the fabrication of low-cost microfluidic chips for efficient reagent mixing in microscale biochemical detection systems. Keywords: 3D printing, Listeria monocytogenes, Microfluidic mixer, Rapid detection.

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Wang, Anyang, Domin Koh, Philip Schneider, Evan Breloff, and Kwang W. Oh. "A Compact, Syringe-Assisted, Vacuum-Driven Micropumping Device." Micromachines 10, no. 8 (August 17, 2019): 543. http://dx.doi.org/10.3390/mi10080543.

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In this paper, a simple syringe‑assisted pumping method is introduced. The proposed fluidic micropumping system can be used instead of a conventional pumping system which tends to be large, bulky, and expensive. The micropump was designed separately from the microfluidic channels and directly bonded to the outlet of the microfluidic device. The pump components were composed of a dead‑end channel which was surrounded by a microchamber. A syringe was then connected to the pump structure by a short tube, and the syringe plunger was manually pulled out to generate low pressure inside the microchamber. Once the sample was loaded in the inlet, air inside the channel diffused into the microchamber through the PDMS (polydimethylsiloxane) wall, acting as a dragging force and pulling the sample toward the outlet. A constant flow with a rate that ranged from 0.8 nl · s − 1 to 7.5 nl · s − 1 was achieved as a function of the geometry of the pump, i.e., the PDMS wall thickness and the diffusion area. As a proof-of-concept, microfluidic mixing was demonstrated without backflow. This method enables pumping for point-of-care testing (POCT) with greater flexibility in hand-held PDMS microfluidic devices.

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Zoupanou, Sofia, Maria Serena Chiriacò, Iolena Tarantini, and Francesco Ferrara. "Innovative 3D Microfluidic Tools for On-Chip Fluids and Particles Manipulation: From Design to Experimental Validation." Micromachines 12, no. 2 (January 21, 2021): 104. http://dx.doi.org/10.3390/mi12020104.

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Micromixers are essential components in lab-on-a-chip devices, of which the low efficiency can limit many bio-application studies. Effective mixing with automation capabilities is still a crucial requirement. In this paper, we present a method to fabricate a three-dimensional (3D) poly(methyl methacrylate) (PMMA) fluidic mixer by combining computer-aided design (CAD), micromilling technology, and experimental application via manipulating fluids and nanoparticles. The entire platform consists of three microfabricated layers with a bottom reservoir-shaped microchannel, a central serpentine channel, and a through-hole for interconnection and an upper layer containing inlets and outlet. The sealing process of the three layers and the high-precision and customizable methods used for fabrication ensure the realization of the monolithic 3D architecture. This provides buried running channels able to perform passive chaotic mixing and dilution functions, thanks to a portion of the pathway in common between the reservoir and serpentine layers. The possibility to plug-and-play micropumping systems allows us to easily demonstrate the feasibility and working features of our device for tracking the mixing and dilution performances of the micromixer by using colored fluids and fluorescent nanoparticles as the proof of concept. Exploiting the good transparency of the PMMA, spatial liquid composition and better control over reaction variables are possible, and the real-time monitoring of experiments under a fluorescence microscope is also allowed. The tools shown in this paper are easily integrable in more complex lab-on-chip platforms.

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Mukherjee, Siddhartha, Jayabrata Dhar, Sunando DasGupta, and Suman Chakraborty. "Patterned surface charges coupled with thermal gradients may create giant augmentations of solute dispersion in electro-osmosis of viscoelastic fluids." Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences 475, no. 2221 (January 2019): 20180522. http://dx.doi.org/10.1098/rspa.2018.0522.

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Augmenting the dispersion of a solute species and fluidic mixing remains a challenging proposition in electrically actuated microfluidic devices, primarily due to an inherent plug-like nature of the velocity profile under uniform surface charge conditions. While a judicious patterning of surface charges may obviate some of the concerning challenges, the consequent improvement in solute dispersion may turn out to be marginal. Here, we show that by exploiting a unique coupling of patterned surface charges with intrinsically induced thermal gradients, it may be possible to realize giant augmentations in solute dispersion in electro-osmotic flows. This is effectively mediated by the phenomena of Joule heating and surface heat dissipation, so as to induce local variations in electrical properties. Combined with the rheological premises of a viscoelastic fluid that are typically reminiscent of common biofluids handled in lab-on-a-chip-based micro-devices, our results demonstrate that the consequent electro-hydrodynamic forcing may open up favourable windows for augmented hydrodynamic dispersion, which has not yet been unveiled.

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Zhang, Peiran, Hunter Bachman, Adem Ozcelik, and Tony Jun Huang. "Acoustic Microfluidics." Annual Review of Analytical Chemistry 13, no. 1 (June 12, 2020): 17–43. http://dx.doi.org/10.1146/annurev-anchem-090919-102205.

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Acoustic microfluidic devices are powerful tools that use sound waves to manipulate micro- or nanoscale objects or fluids in analytical chemistry and biomedicine. Their simple device designs, biocompatible and contactless operation, and label-free nature are all characteristics that make acoustic microfluidic devices ideal platforms for fundamental research, diagnostics, and therapeutics. Herein, we summarize the physical principles underlying acoustic microfluidics and review their applications, with particular emphasis on the manipulation of macromolecules, cells, particles, model organisms, and fluidic flows. We also present future goals of this technology in analytical chemistry and biomedical research, as well as challenges and opportunities.

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Dissertations / Theses on the topic "Microfluidics. Fluidic devices. Mixing"

1

Jang, Ling-Sheng. "Microfluidic mixing technology for biological applications /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/7152.

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Kang, Kai. "Microfluidics of complex liquids." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1064325460.

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Thesis (Ph. D.)--Ohio State University, 2003.
Title from first page of PDF file. Document formatted into pages; contains xiv, 212 p.; also includes graphics. Includes bibliographical references (p. 195-202).

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McDaniel, Kevin Jerome. "Passive mixing on microfluidic devices via dielectric elastomer actuation." Thesis, Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/1032.

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Bickham, Anna V. "Microfabricated Fluidic Devices for Biological Assays and Bioelectronics." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/8470.

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Microfluidics miniaturizes many benchtop processes and provides advantages of low cost, reduced reagent usage, process integration, and faster analyses. Microfluidic devices have been fabricated from a wide variety of materials and methods for many applications. This dissertation describes four such examples, each employing different features and fabrication methods or materials in order to achieve their respective goals. In the first example of microfluidic applications in this dissertation, thermoplastics are hot embossed to form t-shaped channels for microchip electrophoresis. These devices are used to separate six preterm birth (PTB) biomarkers and establish a limit of detection for each. The next chapter describes 3D printed devices with reversed-phase monoliths for solid-phase extraction and on-chip fluorescent labeling of PTB biomarkers. I demonstrate the optimization of the monolith and selective retention of nine PTB biomarkers, the first microchip study to perform an analysis on this entire panel. The third project describes the iterative design and fabrication of glass/polydimethylsiloxane (PDMS) devices with gold and nickel electrodes for the self-assembly of DNA nanotubes for site-selective placement of nanowires. Simple flow channels and “patch electrode” devices were successfully used, and DNA seeding was achieved on gold electrodes. Finally, a 3D printed device for cancer drug screening was developed as a replacement for one previously fabricated in PDMS. Devices of increasing complexity were fabricated, and those tested found to give good control over fluid flow for multiple inlets and valves. Although the applications and methods of these projects are varied, the work in this dissertation demonstrates the potential of microfluidics in several fields, particularly for diagnostics, therapeutics, and nanoelectronics. Furthermore, it demonstrates the importance of applying appropriate tools to each problem to gain specific advantages. Each of the described devices has the potential for increased complexity and integration, which further emphasizes the advantages of miniaturized analyses and the potential for microfluidics for analytical testing in years to come.

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Hoeman, Kurt W. "Novel methods for micellar electro kinetic chromatography and preconcentration on traditional micro fluidic devices and the fabrication and characterization of paper micro fluidic." Diss., Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/2752.

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Lutz, Barry R. "Microeddies as microfluidic elements : reactors and cell traps /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/9857.

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Rask, Olaf Haller. "The Reduction of Mixing Noise and Shock Associated Noise using Chevrons and other Mixing Enhancement Devices." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1223056142.

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Öberg, Månsson Ingrid. "Electroanalytical devices with fluidic control using textile materials and methods." Licentiate thesis, KTH, Fiberteknologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-279327.

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This thesis, written by Ingrid Öberg Månsson at KTH Royal Institute of Technology and entitled “Electroanalytical devices with fluidic control using textile materials and methods”, presents experimental studies on the development of textile based electronic devices and biosensors. One of the reasons why this is of interest is the growing demand for integrated smart products for wearable health monitoring or energy harvesting. To enable such products, new interdisciplinary fields arise combining traditional textile technology and electronics. Textile based devices have garnered much interest in recent years due to their innate ability to incorporate function directly into, for example, clothing or bandages by textile processes such as weaving, knitting or stitching. However, many modifications of yarns required for such applications are not available on an industrial scale. The major objective of this work has been to study how to achieve the performance necessary to create electronic textile devices by either coating yarns with conductive material or using commercially available conductive yarns that are functionalized to create sensing elements. Further, liquid transport within textile materials has been studied to be able to control the contact area between electrolyte and electrodes in electrochemical devices such as sensors and transistors. Yarns with specially designed cross-sections, traditionally used in sportswear to wick sweat away from the body and enhance evaporation, was used to transport electrolyte liquids to come in contact with yarn electrodes. The defined area of the junction where the fluidic yarn meets the conductive yarn was shown to increase stability of the measurements and the reproducibility between devices. The results presented in the two publications of this thesis as well as additional results presented in the thesis itself show the promising potential of using textile materials to integrate electronic and electrochemical functionality in our everyday life. This is shown by using basic textile materials and processing techniques to fabricate complex devices for various application areas such as sensors and diagnostics as well as electrical and energy harvesting components.
Denna avhandling, skriven av Ingrid Öberg Månsson vid Kungliga Tekniska Högskolan och titulerad ”Elektroanalytiska sensorer med vätskekontroll integrerad genom användande av textila material och metoder”, presenterar experimentella studier inom utvecklingen av textilbaserade elektroniska komponenter och biosensorer. Detta är av intresse på grund av den ökade efterfrågan på integrerade smarta produkter som till exempel bärbara sensorer för hälsoövervakning eller för att samla upp och konvertera energi till elektricitet. För att möjliggöra denna typ av produkter föds nya interdisciplinära fält där traditionell textilteknologi och elektronik möts. Textilbaserade enheter har väckt stort intresse under de senaste åren på grund av den naturliga förmågan att integrera funktion i till exempel kläder eller förband genom textila tillverkningsprocesser som väveri, stickning eller sömnad. Många modifikationer hos garner som krävs för att möjliggöra sådana tillämpningar är dock inte tillgängliga i större skala. Därför har det huvudsakliga syftet med denna studie varit att undersöka hur man kan uppnå den prestanda som krävs för att tillverka elektroniska textila komponenter, antingen genom att belägga garner med elektroniskt ledande material eller genom att använda kommersiellt tillgängliga ledande garner som sedan modifieras kemiskt för att skapa sensorer. Utöver detta har vätsketransport inom textila material studerats för att kunna styra och kontrollera kontaktytan mellan elektrolyt och elektroder i elektrokemiska enheter så som sensorer och transistorer. Garner med speciella tvärsnitt, som traditionellt använts i sportkläder för att transportera svett bort från kroppen och underlätta avdunstning, har använts för att transportera elektrolytvätska till elektroder av garn. Den definierade kontaktytan där det vätsketransporterade garnet korsar elektrodgarnet har visats öka stabiliteten av mätningen och reproducerbarheten mellan mätenheter. Resultaten som presenteras i de två artiklar som denna avhandling bygger på samt i avhandlingen själv visar på lovande potential för användandet av textila material för att integrera elektronisk och elektrokemisk funktionalitet i våra vardagsliv. Detta har uppnåtts genom att använda grundläggande textila material och tillverkningsprocesser för att tillverka komplexa enheter för olika tillämpningsområden så som sensorer för diagnostik samt elektroniska komponenter.

QC 2020-08-21

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Luharuka, Rajesh. "An electromagnetically actuated rotary gate microvalve with bistability." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/22576.

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Thesis (Ph. D.)--Mechanical Engineering, Georgia Institute of Technology, 2007.
Committee Chair: Hesketh, Peter J.; Committee Member: Allen, Mark G.; Committee Member: Degertekin, F. Levent; Committee Member: Frazier, Bruno A.; Committee Member: Graham, Samuel.

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"Digital microfluidics using PDMS microchannels." 2004. http://library.cuhk.edu.hk/record=b5891979.

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by Chow Wing Yin, Winnie.
Thesis (M.Phil.)--Chinese University of Hong Kong, 2004.
Includes bibliographical references (leaves 74-78).
Abstracts in English and Chinese.
ABSTRACT --- p.i
摘要 --- p.ii
ACKNOWLEDGEMENTS --- p.iii
TABLE OF CONTENTS --- p.iv
LIST OF FIGURES --- p.vi
LIST OF TABLES --- p.viii
Chapter 1 --- INTRODUCTION --- p.1
Chapter 1.1 --- Digital Microfluidics --- p.1
Chapter 1.2 --- Soft Lithography of Polymer --- p.2
Chapter 2 --- ELECTROCAPILLARY-BASED MICROACTUATION --- p.5
Chapter 2.1 --- Surface Tension in Microscale --- p.5
Chapter 2.2 --- thermocapillary-based microactuation --- p.6
Chapter 2.3 --- electrocapillary-based microactuation --- p.6
Chapter 2.3.1 --- Continuous Electrowetting (CEW) --- p.7
Chapter 2.3.2 --- Electrowetting (EW) --- p.8
Chapter 2.3.3 --- Electrowetting-On-Dielectric (EWOD) --- p.11
Chapter 3 --- SOFT LITHOGRAPHY --- p.14
Chapter 3.1 --- Rapid Prototyping --- p.15
Chapter 3.2 --- Replica Molding --- p.16
Chapter 3.2.1 --- Pouring Method --- p.17
Chapter 3.2.2 --- Sandwich Molding Method --- p.17
Chapter 3.2.3 --- Spin On Method --- p.18
Chapter 3.3 --- Sealing --- p.20
Chapter 3.3.1 --- Reversible Sealing --- p.20
Chapter 3.3.2 --- Irreversible Sealing --- p.20
Chapter 3.4 --- Multilayer Fabrication --- p.21
Chapter 4 --- METAL DEPOSITION --- p.22
Chapter 4.1 --- Gold Deposition by Sputtering Method --- p.22
Chapter 4.1.1 --- Gold Deposition on PMMA --- p.22
Chapter 4.1.2 --- Gold Deposition on PDMS --- p.23
Chapter 4.2 --- ITO Deposition by Sputtering Method --- p.26
Chapter 4.2.1 --- Image Patterning of ITO --- p.27
Chapter 5 --- POLYMER-BASED SUBSTRATES BONDING USING PDMS --- p.29
Chapter 5.1 --- Design of Microfluidic System --- p.29
Chapter 5.1.1 --- PDMS --- p.29
Chapter 5.1.2 --- Design of the Vortex Micropump --- p.30
Chapter 5.2 --- Fabrication of Microfluidic System --- p.31
Chapter 5.2.1 --- Micro Impeller Fabrication Process --- p.31
Chapter 5.2.2 --- Micro Patterning of PMMA by Hot Embossing Technique --- p.32
Chapter 5.2.3 --- Assembly of Micropump by PDMS Bonding Process --- p.34
Chapter 5.3 --- Experimental Results --- p.36
Chapter 5.3.1 --- Tensile Bonding Test --- p.36
Chapter 5.3.2 --- Leakage Test --- p.38
Chapter 6 --- DIGITAL MICROFLUIDICS IN MICROCHANNEL --- p.39
Chapter 6.1 --- Digital Microfluidics --- p.39
Chapter 6.2 --- Design of the MicroChannel --- p.39
Chapter 6.3 --- Materials of the MicroChannel --- p.42
Chapter 6.3.1 --- Substrate --- p.42
Chapter 6.3.2 --- Adhesion Layer --- p.42
Chapter 6.3.3 --- Electrode --- p.43
Chapter 6.3.4 --- Dielectric Layer --- p.43
Chapter 6.4 --- Fabrication of the MicroChannel --- p.44
Chapter 7 --- EXPERIMENTAL RESULTS --- p.46
Chapter 7.1 --- ewod on pdms layer --- p.46
Chapter 7.2 --- PDMS Parallel Plate Channel --- p.48
Chapter 7.2.1 --- Contact Angle --- p.49
Chapter 7.3 --- Parylene C Parallel Plate Channel --- p.52
Chapter 7.4 --- Sealed pdms MicroChannel --- p.54
Chapter 7.5 --- Driving Pressure --- p.55
Chapter 7.6 --- microchannel in the vertical position --- p.57
Chapter 8 --- FUTURE WORK --- p.60
Chapter 8.1. --- Digital Microfluidic Circuit Design --- p.60
Chapter 8.1.1. --- Electrodes Design --- p.61
Chapter 8.2. --- Fabrication Process --- p.63
Chapter 9 --- SUMMARY --- p.64
APPENDIX A --- p.67
BIBLIOGRAPHY --- p.74

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Books on the topic "Microfluidics. Fluidic devices. Mixing"

1

Bruus, Henrik. Theoretical microfluidics. Oxford: Oxford University Press, 2008.

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Gomez, Frank A. Biological applications of microfluidics. Hoboken, N.J: Wiley-Interscience, 2008.

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Gomez, Frank A. Biological applications of microfluidics. Hoboken, N.J: John Wiley, 2008.

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Gomez, Frank A. Biological applications of microfluidics. Hoboken, N.J: John Wiley, 2008.

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Introduction to microfluidics. New York: Oxford University Press, 2005.

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Wei na liu dong li lun ji ying yong. Beijing: Ke xue chu ban she, 2010.

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Koch, Michael. Microfluidic technology and applications. Philadelphia, PA: Research Studies Press, 2000.

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Abgrall, Patrick. Nanofluidics. Boston: Artech House, 2009.

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1970-, Nguyen Nam-Trung, ed. Nanofluidics. Boston: Artech House, 2009.

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Nguyen, Nam-Trung. Micromixers: Fundamentals, design and fabrication. Norwich, NY: William Andrew, 2008.

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Book chapters on the topic "Microfluidics. Fluidic devices. Mixing"

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Bobusch, Bernhard C., Phillip Berndt, Christian O. Paschereit, and Rupert Klein. "Investigation of Fluidic Devices for Mixing Enhancement for the Shockless Explosion Combustion Process." In Notes on Numerical Fluid Mechanics and Multidisciplinary Design, 281–97. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-11967-0_18.

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Sanchez-Claros, Maria, Joaquin Ortega-Casanova, and Francisco Jose Galindo-Rosales. "2D Numerical Study of a Micromixer Based on Blowing and Vortex Shedding Mechanisms." In Process Analysis, Design, and Intensification in Microfluidics and Chemical Engineering, 79–113. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-7138-4.ch003.

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In this chapter, a numerical study and assessment of the mixing efficiency of a novel microfluidic device for mixing two fluids are presented. The device under study consists of a two-dimensional straight microchannel with a square pillar centered across the channel. The main fluid flows through the microchannel from the main inlet to the outlet, while the second fluid is injected through the pillar as two small jets at its upstream corners. For different values of the Reynolds number, intensity ratio between the jets and the main channel stream and jets injection angle, the authors have conducted several numerical simulations to characterize both the mixing efficiency and the required input power to make the fluids flow. The optimum configuration has been revealed for high values of the Reynolds number, low intensity ratios, and high injection angles. Thanks to vortex shedding and the corresponding downstream oscillations, a mixing efficiency of around 90% can be reached. The worst mixing efficiency is obtained for a configuration without vortex shedding, having a mixing efficiency of only around 2%.

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Buranda, Tione, and Larry A. Sklar. "Flow Cytometry, Beads, and Microchannels." In Flow Cytometry for Biotechnology. Oxford University Press, 2005. http://dx.doi.org/10.1093/oso/9780195183146.003.0010.

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Microfluidic devices generally consume microliter to submicroliter volumes of sample and are thus well suited for use when the required reagents are scarce or expensive. Because microfluidic devices operate in a regime in which small Reynolds numbers govern the delivery of fluid samples, reagent mixing and subsequent reactivity has been a severe limiting factor in their applicability. The inclusion of packed beads in the microfluidic device repertoire has several advantages: molecular assemblies for the assay are created outside the channel on beads and characterized with flow cytometry, uniform populations of beads may be assured through rapid cytometric sorting, beads present a larger surface area for the display of receptors than flat surfaces, rapid mixing in the microcolumn is achieved because the distance that must be covered by diffusion is limited to the (≤1-μm) interstitial space between the closely packed receptorbearing beads, and analytes are captured in a flow-through format and, as such, each bead can act as a local concentrator of analytes. Progress in the combined use of beads and microfluidic devices has been limited by the ability to pack beads at specific sections of microfluidic devices. A subsequent challenge associated with the packed microcolumns of beads is the substantial pressure drop that affects the fluid flow velocity. However, some of these challenges have been overcome in the design of simple model systems that have potential applications in DNA analysis, chromatography, and immunoassays. It is the intent of this chapter to examine the recent emergence of small-volume heterogeneous immunoassays, using beads trapped in microchannels, while excluding other closely related applications such as capillary electrophoresis and flow injection–based approaches. Of necessity, the authors’ interests and availability of information pertinent to the specific discussions presented below impose additional restrictions. To date, there are only a handful of applications that combine packed beads and microfluidic devices, and even fewer that make the overt connection between flow cytometry–based assays and beads. Harrison and coworkers have provided one of the earliest conceptual demonstrations of the capability to incorporate packed beads in microfluidic devices for analytical purposes.

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Fan, Jing, Shuaijun Li, Ziqian Wu, and Zi Chen. "Diffusion and mixing in microfluidic devices." In Microfluidics for Pharmaceutical Applications, 79–100. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-12-812659-2.00003-x.

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Zhang, Yuezhou, Dongfei Liu, Hongbo Zhang, and Hélder A. Santos. "Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems." In Microfluidics for Pharmaceutical Applications, 155–77. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-12-812659-2.00007-7.

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P. Fuentes, Olga, Mabel J. Noguera, Paula A. Peñaranda, Sergio L. Flores, Juan C. Cruz, and Johann F. Osma. "Micromixers for Wastewater Treatment and Their Life Cycle Assessment (LCA)." In Advances in Microfluidics and Nanofluids. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96822.

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The use of micromixers and catalytically active nanocomposites can be an attractive alternative for the treatment of wastewaters from the textile industry, due to their high activity, low consumption of such nanocomposites, short reaction times and the possibility to work under continuous operation. In this study, 6 different designs of micromixers were modeled and evaluated for the treatment of wastewaters. Velocity profiles, pressure drops, and flows were analyzed and compared for the different devices under the same mixing conditions. In addition, Life cycle assessment (LCA) methodology was applied to determine their performance in terms of environmental impact. Considering the high environmental impact of water sources contaminated by dyes from the textile industry, it becomes critically important to determine when the proposed micromixers are a suitable alternative for their remediation. The LCA and operational efficiency studies results shown here provide a route for the design of novel wastewater treatment systems by coupling low-cost and high-performance micromixers.

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Fu, Anne Y., and Yohei Yokobayashi. "Elastomeric Microfabricated Fluorescence-Activated Cell Sorters." In Flow Cytometry for Biotechnology. Oxford University Press, 2005. http://dx.doi.org/10.1093/oso/9780195183146.003.0009.

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This chapter describes the development of elastomeric microfabricated cell sorters that allow for high sensitivity, no cross contamination, and lower cost than any conventional fluorescence-activated cell sorting. The course of this development depends heavily on two key technologies that have advanced rapidly within the past decade: microfluidics and soft lithography. Sorting in the microfabricated cell sorter is accomplished via different means of microfluidic control. This confers several advantages over the conventional sorting of aerosol droplets: novel algorithms of sorting or cell manipulation can be accomplished, dispensing of reagents and biochemical reactions can occur immediately before or after the sorting event, completely enclosed fluidic devices allow for studies of biohazardous/infectious cells or particles in a safer environment, and integration of other technologies can be implemented into the cell sorter. In addition, because of the easy fabrication process and inexpensive materials used in soft lithography, this elastomeric microfabricated cell sorter is affordable to every research laboratory and can be disposable just as a gel in gel electrophoresis, which eliminates any cross contamination from previous runs. Because of the advent of soft lithography, many inexpensive, flexible, and microfabricated devices could be designed to replace flow chambers in conventional flow cytometers. Soft lithography is a micromachining technique that uses the process of rapid prototyping and replica molding to fabricate inexpensive elastomeric microfluidic devices with materials such as plastics and polymers. The elastomeric properties of plastics and polymers allow for an easy fabrication process and for cleaning for reuse or disposal. A variety of biological assays can also be carried out as a result of the chemical compatibilities of different plastic materials with different solvents. More accurate sorting of cells can be accomplished because the sorting region is at or immediately after the interrogation point. On-chip chemical processing of cells has been accomplished and can be observed at any spot on the chip before or after sorting. Time-course measurements of a single cell for kinetic studies can be implemented using novel sorting schemes. Furthermore, linear arrays of channels on a single chip, the multiplex system, may be simultaneously detected by an array of photomultiplier tubes (PMT) for multiple analysis of different channels.

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"colloid mills, piston homogenizers, rotor/stator mixers, Microfluidizer™ (a registered trademark of Microfluidics International Corp.) technologies, ultrasonic mixers, and hybrid devices. Each uses a unique processing technique to shear a mixture or com-bine the flows of materials in order to form an emulsion or suspensions. Most of the time these devices are not used in a truly continuous process. Rather, after the compo-nents of a dispersed delivery system are combined and blended in a batch vessel, the components in the mixture are passed through the device, and the shearing and mixing that take place inside the device affect particle size reduction, dispersion, and emulsi-fication. 1. Rotor/Stator Mixer Disperser Emulsifiers "All mixers pump and all pumps mix." This is reflected in the earlier-shown power equation, Eq. (3). A type of in-line device that is very similar to a rotor/stator batch mixer is the rotor/stator continuous mixer disperser emulsifier. Indeed, most of the designs of this type of in-line high-shear device are essentially identical to the batch equipment designs of a given manufacturer. Since rotor/stator batch mixers are acting as submerged pumps, a design can be made that places the rotor/stator in a pump hous-ing and allows for product to be pumped through itself (Fig. 27). During the time the product is inside the rotor/stator mixing pump, the droplets and particles are subjected to a wide variety of high shear rates. All pumps of any kind impart some level of shear to the product that passes through the pump. Rotor/stator mixing pumps are designed with fine tolerance rotor/stator gaps that promote the high shear rates and high amounts of shear per pass through. Shear rates in a rotor/stator in-line mixer are equal to those in rotor/stator batch mixers. The maximum shear rates occur in the gap between the high-speed rotating Fig. 27 Rotor/stator in-line mixer disperser emulsifier. (From Ref. 31.)." In Pharmaceutical Dosage Forms, 356. CRC Press, 1998. http://dx.doi.org/10.1201/9781420000955-49.

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Conference papers on the topic "Microfluidics. Fluidic devices. Mixing"

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Barona, David, and A. Amirfazli. "A Robust Superhydrophobic Surface for Digital Microfluidics." In ASME 2011 9th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2011. http://dx.doi.org/10.1115/icnmm2011-58159.

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Digital microfluidics depends on efficient movement of individual drops for a variety of tasks, e.g. reagent delivery, mixing, sampling, etc. Superhydrophobic (SH) coatings generally show high repellency and low adhesion for a variety of liquids. Therefore, SH coatings can provide for an efficient drop delivery and hence low energy requirements for a fluidic chip. However, wide application of such coatings is hampered by fragile nature of such coatings to date. A new SH coating is developed that addresses the fragility challenge of such coatings. It is based on application of nanoparticles to fluoropolymers. The mechanical stability, wear resistance and durability under prolonged liquid exposure of this new coating is discussed. It is shown that the new SH coating can maintain high contact angles, low contact angle hysteresis needed for drop mobility under adverse conditions/application of digital microfluidic devices. The developed SH coating can also be sprayed onto various surfaces, including glass used in traditional lab-on-chip (LOC) devices, or even paper for enabling novel Lap-on-paper (LOP) devices.

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Surendran, Athira N., and Ran Zhou. "Active High-Throughput Micromixer Using Injected Magnetic Mixture Underneath Microfluidic Channel." In ASME 2020 18th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2020 Heat Transfer Summer Conference and the ASME 2020 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/icnmm2020-1018.

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Abstract Microfluidics has a lot of applications in fields ranging from pharmaceutical to energy, and one of the major applications is micromixers. A challenge faced by most micromixers is the difficulty in mixing within micro-size fluidic channels because of the domination of laminar flow in a small channel. Hence, magnetic field generated by permanent magnets and electromagnets have been widely used to mix ferrofluids with other sample fluids on a micro level. However, permanent magnets are bulky, and electromagnets produce harmful heat to biological samples; both properties are detrimental to a microfluidic chip’s performance. Taking these into consideration, this study proposes rapid mixing of ferrofluid using a two-layer microfluidic device with microfabricated magnet. Two microfluidic chips that consist of microchannels and micromagnets respectively are fabricated using a simple and low-cost soft lithography method. The custom-designed microscale magnet consists of an array of stripes and is bonded below the plane of the microchannel. The combination of the planar location and angle of the array of magnets allow the migration of ferrofluids, hence mixing it with buffer flow. Parametric studies are performed to ensure comprehensive understanding, including the angle of micro-scale magnets with respect to the fluidic channels, total flow rate and density of the array of magnets. The result from this study can be applied in chemical synthesis and pre-processing, sample dilution, or inducing reactions between samples and reagent.

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Dankovic, Tatjana, Gareth Hatch, and Alan Feinerman. "Fabrication of Plastic Micro-Channels for Microfluidics Solvent Extraction." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-53526.

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In this work plastic micro channel systems were investigated as a potential device for micro solvent extraction of rare earth elements. The proposed microfluidic structures are made by laser welding of three layers of inexpensive thermoplastic films which form separate paths (top and bottom channels) for each of the immiscible fluids. The middle layer is perforated in order to provide contact between two fluids and to enable the extraction process. Experiments were performed to show that two different immiscible fluids (water and 1-octanol) can flow through the fabricated device and exit at separate outlets without mixing even when those fluids get into close contact within the main channel. Experimental results for single devices show that immiscible fluids can be brought into intimate contact and then separated with compliant polymeric microfluidic devices. The transfer of a compound from one immiscible fluid to the other was verified by dye exchange between the immiscible fluids. The same fabrication method is a promising technique for fabrication of massively parallel systems with larger throughput.

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Guduru, Rakesh, and Nazmul Islam. "Electrokinetic Driven Micro-Mixing of Fluids in a Circular Electrode Pattern." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-72209.

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Manipulation of fluids in a small volume is often a challenge in the field of Microfluidics. While many research groups have addressed this issue with robust methodologies, manipulation of fluids remains a scope of study due to the ever-changing technology (Processing Tools) and increase in the demand for “Lab-On-a-Chip” devices. This research peruses the flow pattern and fluid mixing behavior in a metallic circular electrode, charged with AC voltage. In this study, micromixing in a circular electrode pattern device is demonstrated with numerical and experimental values. Experiments were performed using two buffer solutions with conductivities 1.62 S/m and 0.0732 S/m. The efficiency of mixing was found to be three to five times faster than the normal diffusion process. It was found that the increase in the conductivity of fluid increases the efficiency of mixing in the proposed device.

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Fadl, Ahmed, Stefanie Demming, Zongqin Zhang, Bjo¨rn Hoxhold, Stephanus Bu¨ttgenbach, Manfred Krafczyk, and Donna M. L. Meyer. "A Multifunctional Microfluidic Device Based on Bifurcation Geometry." In ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels collocated with 3rd Joint US-European Fluids Engineering Summer Meeting. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-30950.

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Developing multifunctional devices are essential to realize more efficient Microsystems. With miniaturization processes taking place in many different applications, the rooms for single function microfluidic devices are limited. In this study, we introduce a multifunctional micro fluidic device based on bifurcation geometry which is capable of performing pumping and mixing at the same time. Optical lithography is used to fabricate the designed microfluidic device. The microfluidic device is tested at low actuator frequencies, and ethanol is employed as a working fluid. The operational principles are based on rectifying the oscillatory flows by using bifurcation structures for flow rectification. The results prove the feasibility of the novel design, and results are presented in terms of flow rates and maximum back pressures.

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Morales, Mercedes C., and Jeffrey D. Zahn. "Development of a Diffusion Limited Microfluidic Module for DNA Purification via Phenol Extraction." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-68086.

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Purification of Deoxyribonucleic acid (DNA) by organic-aqueous liquid extraction, also called phenol extraction, is a standard technique commonly utilized in biology laboratories. In order to minimize interaction energies, membrane components and proteins naturally partition to the organic (phenol) phase while the DNA stays in the aqueous phase, where it can be easily removed. In recent years, microfluidics has become a driving force toward more efficient and autonomous platforms for fluid based diagnostics, chemical reaction chambers, separation and preparation of biological materials. In this work, fabrication, and performance of a long microfluidic device for DNA extraction are presented. The devices were fabricated using soft lithography to transfer lithographically defined features into a PDMS structure via replica molding. Stratified-flow experiments using a rhodamine dye conjugated bovine serum albumin protein (BSA) in an aqueous phase were conducted to demonstrate the ability to remove proteins from the aqueous phase into the phenol phase. Additionally, the study of BSA partitioning and DNA isolation in a two-phase system under stratified flow condition were presented, separately and conjunctly. Finally, protein partitioning and DNA recovery obtained with this device could be compared with other types of mixing and extraction such as mixing by droplet formation and electrohydrodynamic (EHD) instability.

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Loire, Sophie, Paul Kauffmann, Paul Gimenez, Igor Mezić, and Carl Meinhart. "Electrothermal Blinking Vortices for Chaotic Mixing." In ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-88269.

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Thanks to its favorable reduction scale law, and its easy integration, electrokinetics has emerged over the last fifteen years as one of the major solution to drive flows in fully integrated lab-on-chip. At microscale, an efficient mixing is a keystep which can dramatically accelerate bio-reactions. For thirty years, Dynamical System theory has predicted that chaotic mixing must involve at least 3 dimensions (either time dependent 2D flows or 3D flows). However, in microfluidics, few works have yet presented efficient embedded micromixers. This paper presents experimental and theoretical study of 2D time dependent chaotic mixing using AC electrothermal fluid flows. Experiments and numerical simulations are performed on a top view device and a sideview device. In both devices, a sinusoidal electric signal is applied between 3 interdigitated gold electrodes. A phase signal Vpp = 11V and a ground are switched between the two side electrodes using a step function, whereas the opposite phase signal –Vpp is steadily applied to the center electrode (Figure 1). Flow velocity is measured by micro particle image velocimetry μ PIV. The velocity profile shows a dramatic asymmetry between the two vortices. Therefore, during the switch, vortices overlap, leading to stretching and folding flows required to obtain chaotic mixing (Figure 3 and 4). The experimental measurements validate our electrothermal models based on our previous work [1]. The mixing efficiency of low diffusive particles is studied at multiscale using the mix-variance coefficient (MVC) [2] to evaluate mixing at different scales (Figure 4). To do so, the domain is successively divided in boxes along the x and y direction up to nx and ny boxes, respectively. For each box configuration, average bead concentration is computed. The variance of these concentrations is then evaluated: MVCs=1nxny∑i=1ny∑j=1nxρij-0.52. The result of numerically evaluated MVC in Figure 2 show a dramatic increase of mixing efficiency with blinking vortices compared to steady flow. Theoretical, experimental and simulation results of the mixing process will be presented.

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O¨zdemir, Mehmed Rafet, Ali Kos¸ar, Orc¸un Demir, Cemre O¨zenel, and Og˘uzhan Bahc¸ivan. "Thermal Hydraulic, Exergy and Exergy-Economic Analysis of Micro Heat Sinks at High Flow Rates." In ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2010. http://dx.doi.org/10.1115/esda2010-25239.

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Recently, micro/nanofabrication technology has been used to develop a number of microfluidic systems. With its integration to microfluidic devices, microchannels and micro scale pin fin heat sinks find applications in many areas such as drug delivery and propulsion in biochemical reaction chambers and micro mixing. Many research efforts have been performed to reveal thermal and hydrodynamic performances of microchannel based micro fluidic devices. In the current study, it is aimed to extend the knowledge on this field by investigating heat and fluid flow in micro heat sinks at high flow rates. Moreover, thermodynamic and thermo-economic aspects were also considered. De-ionized water was used as the coolant in the system. Flow rates were measured over pressures of 20–80 psi. A serpentine heater was deposited at the back of the micro pin fin devices to enable the delivery of heat to these devices. Two micro-pin fin devices each having different geometrical properties (Circular based and Hydrofoil based) were used in this study. In addition, the performances (thermal-hydraulic, exergy, exergo-economic) were also experimentally obtained for a plain microchannel device. Thermal resistances, exergy efficiencies and thermo-economic parameters were obtained from the devices and their performances were assessed.

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Cetin, Barbaros, Serdar Taze, Mehmet D. Asik, and S. Ali Tuncel. "Microfluidic Device for Synthesis of Chitosan Nanoparticles." In ASME 2013 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fedsm2013-16349.

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Chitosan nanoparticles have a biodegradable, biocompatible, non-toxic structure, and commonly used for drug delivery systems. In this paper, simulation of a microfluidic device for the synthesis of chitosan nanoparticle is presented. The flow filed together with the concentration field within the microchannel network is simulated using COMSOL Multiphysics® simulation environment. Different microchannel geometries are analyzed, and the mixing performance of these configurations are compared. As a result, a 3D design for a microfluidics platform which includes four channel each of which performs the synthesis in parallel is proposed. Future research directions regarding the fabrication of the microfluidic device and experimentation phase are addressed and discussed.

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Kongthon, Jiradech, Jae-Hyun Chung, James Riley, and Santosh Devasia. "Dynamics of Cilia-Based Microfluidic Devices." In ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control. ASMEDC, 2011. http://dx.doi.org/10.1115/dscc2011-5936.

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This article models the dynamics of cilia-based devices (soft cantilever-type, vibrating devices that are excited by external vibrations) for mixing and manipulating liquids in microfluidic applications. The main contribution of this article is to develop a model, which shows that liquid sloshing and the added mass effect play substantial roles in generating large-amplitude motion of the cilia. Additionally, experimental results are presented to show that (i) mixing is substantially improved with the use of cilia when compared to the case without cilia and (ii) mixing with cilia can be further enhanced by using an asymmetric excitation waveform when compared to sinusoidal excitation.

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