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Journal articles on the topic 'Microfold cells'

Author: Grafiati

Published: 4 June 2025

Last updated: 14 July 2025

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1

Fujimura, Yoshinori. "Functional morphology of microfold cells (M cells) in Peyer’s patches." Gastroenterologia Japonica 21, no. 4 (1986): 325–34. http://dx.doi.org/10.1007/bf02774129.

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2

Fujimura, Y., T. Kihara, K. Ohtani, et al. "Distribution of microfold cells(M cells) in human follicle-associated epithelium." Gastroenterologia Japonica 25, no. 1 (1990): 130. http://dx.doi.org/10.1007/bf02785340.

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3

Nair, Vidhya R., Luis H. Franco, Vineetha M. Zacharia, et al. "Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection." Cell Reports 16, no. 5 (2016): 1253–58. http://dx.doi.org/10.1016/j.celrep.2016.06.080.

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4

Li, Qiu-Xuan, Yue-Xin Guo, Rong-Xuan Hua, Hong-Wei Shang, Li-Sheng Li, and Jing-Dong Xu. "New insight into function and dysfunction of gut microfold cells." World Chinese Journal of Digestology 29, no. 4 (2021): 197–203. http://dx.doi.org/10.11569/wcjd.v29.i4.197.

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5

Mabbott, N. A., D. S. Donaldson, H. Ohno, I. R. Williams, and A. Mahajan. "Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium." Mucosal Immunology 6, no. 4 (2013): 666–77. http://dx.doi.org/10.1038/mi.2013.30.

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6

Li, Yang, Shanshan Yang, Xin Huang, et al. "MyD88 Mediates Colitis- and RANKL-Induced Microfold Cell Differentiation." Veterinary Sciences 9, no. 1 (2021): 6. http://dx.doi.org/10.3390/vetsci9010006.

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Intestinal microfold (M) cells are critical for sampling antigens in the gut and initiating the intestinal mucosal immune response. In this study, we found that the oral administration of dextran sulfate sodium (DSS) and Salmonella infection induced colitis. In the process, the expression levels of M cell differentiation-related genes were synchronized with the kinetics of pro-inflammatory cytokines. Compared to wild-type (WT) mice, MyD88−/− mice exhibited significantly lower expression levels of M cell differentiation-related genes. However, DSS induced colitis in MyD88−/− mice but failed to

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7

Surve, Manalee V., Brian Lin, Jennifer L. Reedy, et al. "Single-Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells." American Journal of Respiratory Cell and Molecular Biology 69, no. 6 (2023): 698–701. http://dx.doi.org/10.1165/rcmb.2023-0292le.

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8

Uchida, Junichi. "Electron microscopic study of microfold cells (M cells) in normal and inflamed human appendix." Gastroenterologia Japonica 23, no. 3 (1988): 251–62. http://dx.doi.org/10.1007/bf02779467.

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9

Rouch, Joshua D., Andrew Scott, Nan Ye Lei, et al. "Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids." PLOS ONE 11, no. 1 (2016): e0148216. http://dx.doi.org/10.1371/journal.pone.0148216.

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10

Nowak, Bernadetta, Marta Wanat, Ada Świątko, et al. "Exploring the microscopic terrain of the small intestinal epithelium: a comprehensive overview of general architecture and the present understanding of intestinal stem cells." Medical Journal of Cell Biology 11, no. 3 (2023): 87–92. http://dx.doi.org/10.2478/acb-2023-0015.

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Abstract This paper provides a comprehensive overview of the microscopic landscape of the small intestinal epithelium, focusing on its general structure and the current state of knowledge regarding intestinal stem cells. The small intestine’s epithelial layer is intricately organized, comprising various cell types with specialized functions, including goblet cells, enterocytes, enteroendocrine cells, Paneth cells, microfold cells (M cells), and tuft cells. These cells collectively contribute to essential physiological processes such as digestion, absorption, and immune response regulation. The

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11

Rouch, Joshua D., Andrew Scott, Nan Ye Lei, et al. "31 Development of Functional Microfold (M) Cells From Intestinal Stem Cells in Primary Human Enteroids." Gastroenterology 150, no. 4 (2016): S11. http://dx.doi.org/10.1016/s0016-5085(16)30166-4.

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12

Xiang, Li, Wenxu Pan, Huan Chen, et al. "Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression." Mediators of Inflammation 2024 (May 2, 2024): 1–11. http://dx.doi.org/10.1155/2024/7524314.

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Objective. Microfold cells (M cells) are specific intestinal epithelial cells for monitoring and transcytosis of antigens, microorganisms, and pathogens in the intestine. However, the mechanism for M-cell development remained elusive. Materials and Methods. Real-time polymerase chain reaction, immunofluorescence, and western blotting were performed to analyze the effect of sorbitol-regulated M-cell differentiation in vivo and in vitro, and luciferase and chromatin Immunoprecipitation were used to reveal the mechanism through which sorbitol-modulated M-cell differentiation. Results. Herein, in

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13

KIDO, Taketomo, Shyuichi OHWADA, Kouichi WATANABE, Hisashi ASO, and Takahiro YAMAGUCHI. "Differential characteristics of microfold cells on the dome epithelium of porcine ileum." Animal Science Journal 74, no. 5 (2003): 375–82. http://dx.doi.org/10.1046/j.1344-3941.2003.00129.x.

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14

Tong, Tianjian, Yijun Qi, Luke D. Bussiere, et al. "Transport of artificial virus-like nanocarriers through intestinal monolayers via microfold cells." Nanoscale 12, no. 30 (2020): 16339–47. http://dx.doi.org/10.1039/d0nr03680c.

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15

George, Joel Johnson, Laura Martin-Diaz, Markus J. T. Ojanen, Rosa Gasa, Marko Pesu, and Keijo Viiri. "PRC2 Regulated Atoh8 Is a Regulator of Intestinal Microfold Cell (M Cell) Differentiation." International Journal of Molecular Sciences 22, no. 17 (2021): 9355. http://dx.doi.org/10.3390/ijms22179355.

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Intestinal microfold cells (M cells) are a dynamic lineage of epithelial cells that initiate mucosal immunity in the intestine. They are responsible for the uptake and transcytosis of microorganisms, pathogens, and other antigens in the gastrointestinal tract. A mature M cell expresses a receptor Gp2 which binds to pathogens and aids in the uptake. Due to the rarity of these cells in the intestine, their development and differentiation remain yet to be fully understood. We recently demonstrated that polycomb repressive complex 2 (PRC2) is an epigenetic regulator of M cell development, and 12 n

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16

Kolawole, Abimbola O., Mariam B. Gonzalez-Hernandez, Holly Turula, Chenchen Yu, Michael D. Elftman, and Christiane E. Wobus. "Oral Norovirus Infection Is Blocked in Mice Lacking Peyer's Patches and Mature M Cells." Journal of Virology 90, no. 3 (2015): 1499–506. http://dx.doi.org/10.1128/jvi.02872-15.

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ABSTRACTA critical early step in murine norovirus (MNV) pathogenesis is crossing the intestinal epithelial barrier to reach the target cells for replication, i.e., macrophages, dendritic cells, and B cells. Our previous work showed that MNV replication decreases in the intestines of mice conditionally depleted of microfold (M) cells. To define the importance of Peyer's patch (PP) M cells during MNV pathogenesis, we used a model of BALB/c mice deficient in recombination-activating gene 2 (Rag2) and the common gamma chain (γc) (Rag-γc−/−), which lack gut-associated lymphoid tissues (GALT), such

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17

Nagashima, Kazuki, and Hiroshi Takayanagi. "Intestinal homeostasis governed by mesenchymal stromal cells." Journal of Immunology 198, no. 1_Supplement (2017): 62.3. http://dx.doi.org/10.4049/jimmunol.198.supp.62.3.

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Abstract The mammalian intestine harbors numerous bacteria and contains a large number of immune cells. A continuous dialogue between immune cells and luminal microbes is critical for the maintenance of the intestinal homeostasis. The intestinal epithelium is a single-layered cell sheet that separates numerous microbes and the immune system. The appropriate development and maintenance of the epithelium are essential for the clearance of pathogens and the prevention of excess immune responses against commensal microbes. Microfold (M) cells are epithelial cells specialized for bacterial sampling

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18

Gonzalez-Hernandez, M. B., T. Liu, H. C. Payne, et al. "Efficient Norovirus and Reovirus Replication in the Mouse Intestine Requires Microfold (M) Cells." Journal of Virology 88, no. 12 (2014): 6934–43. http://dx.doi.org/10.1128/jvi.00204-14.

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19

Mutoh, Mami, Shunsuke Kimura, Hiromi Takahashi-Iwanaga, Meri Hisamoto, Toshihiko Iwanaga, and Junichiro Iida. "RANKL regulates differentiation of microfold cells in mouse nasopharynx-associated lymphoid tissue (NALT)." Cell and Tissue Research 364, no. 1 (2015): 175–84. http://dx.doi.org/10.1007/s00441-015-2309-2.

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20

Fujimura, Y., T. Kihara, M. Hosobe, et al. "Measurement of microvilli of Microfold cells (M-cells) and absorptive cells in follicle-associated epithelium of mouse Peyer’s patches." Gastroenterologia Japonica 25, no. 4 (1990): 508. http://dx.doi.org/10.1007/bf02779343.

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21

Kimura, Shunsuke, Nobuhide Kobayashi, Yutaka Nakamura, et al. "Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice." Journal of Experimental Medicine 216, no. 4 (2019): 831–46. http://dx.doi.org/10.1084/jem.20181604.

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Microfold (M) cells residing in the follicle-associated epithelium (FAE) of the gut-associated lymphoid tissue are specialized for antigen uptake to initiate mucosal immune responses. The molecular machinery and biological significance of M cell differentiation, however, remain to be fully elucidated. Here, we demonstrate that Sox8, a member of the SRY-related HMG box transcription factor family, is specifically expressed by M cells in the intestinal epithelium. The expression of Sox8 requires activation of RANKL-RelB signaling. Chromatin immunoprecipitation and luciferase assays revealed that

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22

Sun, Xiaomeng, Yuxuan Wu, Chenhua Han, Na Zhang, Xin Chen, and Yunzi Chen. "Intestinal epithelial vitamin D receptor defense against inflammatory bowel disease via regulating microfold cells." Immunology Letters 270 (December 2024): 106925. http://dx.doi.org/10.1016/j.imlet.2024.106925.

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23

Kunimura, Kazufumi, Daiji Sakata, Xin Tun, et al. "S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer’s Patches." Cell Reports 29, no. 9 (2019): 2823–34. http://dx.doi.org/10.1016/j.celrep.2019.10.091.

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24

Choi, Hyunjin, Shohei Kaneko, Yusei Suzuki, Kosuke Inamura, Masaki Nishikawa, and Yasuyuki Sakai. "Size-Dependent Internalization of Microplastics and Nanoplastics Using In Vitro Model of the Human Intestine—Contribution of Each Cell in the Tri-Culture Models." Nanomaterials 14, no. 17 (2024): 1435. http://dx.doi.org/10.3390/nano14171435.

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Pollution by microplastics and nanoplastics (MNPs) raises concerns, not only regarding their environmental effects, but also their potential impact on human health by internalization via the small intestine. However, the detailed pathways of MNP internalization and their toxicities to the human intestine have not sufficiently been understood, thus, further investigations are required. This work aimed to understand the behavior of MNPs, using in vitro human intestine models, tri-culture models composed of enterocyte Caco-2 cells, goblet-like HT29-MTX-E12 cells, and microfold cells (M cells) ind

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25

Bąska, Piotr, and Luke James Norbury. "The Role of the Intestinal Epithelium in the “Weep and Sweep” Response during Gastro—Intestinal Helminth Infections." Animals 12, no. 2 (2022): 175. http://dx.doi.org/10.3390/ani12020175.

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Helminths are metazoan parasites infecting around 1.5 billion people all over the world. During coevolution with hosts, worms have developed numerous ways to trick and evade the host immune response, and because of their size, they cannot be internalized and killed by immune cells in the same way as bacteria or viruses. During infection, a substantial Th2 component to the immune response is evoked which helps restrain Th1-mediated tissue damage. Although an enhanced Th2 response is often not enough to kill the parasite and terminate an infection in itself, when tightly coordinated with the ner

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26

Lin, Jian, Chunxiao Mou, Shuai Zhang, Liqi Zhu, Yuchen Li, and Qian Yang. "Immune Responses Induced by Recombinant Bacillus subtilis Expressing the PEDV Spike Protein Targeted at Microfold Cells." Veterinary Sciences 9, no. 5 (2022): 211. http://dx.doi.org/10.3390/vetsci9050211.

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Bacillus subtilis (B. subtilis), a probiotic bacterium and feeding additive, is widely used for heterologous antigen expression and protective immunisation. Porcine epidemic diarrhoea virus (PEDV) invades swine via mucosal tissue. To enhance the mucosal immune response to PEDV, we modified B. subtilis to express a PEDV antigen and used it as a mucosal vaccine delivery system. Initially, we constructed a recombinant B. subtilis strain (B.s-RCL) that expressed the PEDV spike protein and L-Lectin-β-GF, with the goal of inducing mucosal secretory immunoglobulin A (sIgA) and anti-PEDV serum immunog

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27

Lin, Jian, Chunxiao Mou, Shuai Zhang, Liqi Zhu, Yuchen Li, and Qian Yang. "Immune Responses Induced by Recombinant Bacillus subtilis Expressing the PEDV Spike Protein Targeted at Microfold Cells." Veterinary Sciences 9, no. 5 (2022): 211. http://dx.doi.org/10.3390/vetsci9050211.

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Bacillus subtilis (B. subtilis), a probiotic bacterium and feeding additive, is widely used for heterologous antigen expression and protective immunisation. Porcine epidemic diarrhoea virus (PEDV) invades swine via mucosal tissue. To enhance the mucosal immune response to PEDV, we modified B. subtilis to express a PEDV antigen and used it as a mucosal vaccine delivery system. Initially, we constructed a recombinant B. subtilis strain (B.s-RCL) that expressed the PEDV spike protein and L-Lectin-β-GF, with the goal of inducing mucosal secretory immunoglobulin A (sIgA) and anti-PEDV serum immunog

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28

Schreiner, Jonas, Felix E. B. Brettner, Stefanie Gier, Sarah Vogel-Kindgen, and Maike Windbergs. "Unlocking the potential of microfold cells for enhanced permeation of nanocarriers in oral drug delivery." European Journal of Pharmaceutics and Biopharmaceutics 202 (September 2024): 114408. http://dx.doi.org/10.1016/j.ejpb.2024.114408.

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29

Fasciano, Alyssa C., and Joan Mecsas. "Eat Your Vitamin A: A Role for Retinoic Acid in the Development of Microfold Cells." Gastroenterology 159, no. 1 (2020): 34–36. http://dx.doi.org/10.1053/j.gastro.2020.05.029.

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30

Kanaya, Takashi, Koji Hase, Daisuke Takahashi, et al. "The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells." Nature Immunology 13, no. 8 (2012): 729–36. http://dx.doi.org/10.1038/ni.2352.

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31

El-Bassouny, Dalia R., and Tarek Essa. "Ultrastructural study on microfold cells and microvillus cells in the follicle-associated epithelium over Peyer’s patches in albino rat." Egyptian Journal of Histology 36, no. 4 (2013): 837–46. http://dx.doi.org/10.1097/01.ehx.0000437938.07612.a2.

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32

Meyerholz, D. K., T. J. Stabel, M. R. Ackermann, S. A. Carlson, B. D. Jones, and J. Pohlenz. "Early Epithelial Invasion by Salmonella enterica Serovar Typhimurium DT104 in the Swine Ileum." Veterinary Pathology 39, no. 6 (2002): 712–20. http://dx.doi.org/10.1354/vp.39-6-712.

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Salmonella enterica serovar Typhimurium is an important intestinal pathogen in swine. This study was performed to document the early cellular invasion of Salmonella serovar Typhimurium in swine ileum. Ileal gut-loops were surgically prepared in ten 4- to 5-week-old mixed-breed pigs and inoculated for 0-60 minutes. Loops were harvested and prepared for both scanning and transmission electron microscopy (SEM and TEM, respectively). Preferential bacterial adherence to microfold cells (M cells) was seen within 5 minutes, and by 10 minutes bacterial invasion of the apical membrane was seen in M cel

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33

Ikram Hasanuddin, Abdi Dzul, Nanang Roswita, and Ivan Virnanda Amu. "Immune Response toward Mycobacterium Tuberculosis Infection." Green Medical Journal 2, no. 2 (2020): 77–87. http://dx.doi.org/10.33096/gmj.v2i2.47.

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Understanding the human immune response toward Mycobacterium tuberculosis infection is important for controlling its infection. Its transmission through the air consists of "droplets nuclei" containing TB bacilli. After initial infection, the human body will provide diverse immune responses and will determine different clinico-histopathologic finding. This response starts from innate immunity that consists of phagocytosis by distal alveolar macrophages or nasal microfold cells, then will be continued by dendritic cells to be transferred to mediastinal lymph nodes to induced adaptive immune res

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34

Goodfield, Laura, Sarah Muse, and Eric Harvill. "Examining the local response in the mucosa: how microfold cells act as first responders during a bordetella infection (MPF3P.811)." Journal of Immunology 192, no. 1_Supplement (2014): 132.11. http://dx.doi.org/10.4049/jimmunol.192.supp.132.11.

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Abstract During a respiratory tract infection, the first interaction between the pathogen and host occurs at the mucosal interface. Microfold (M) cells, specialized antigen sampling cells associated with the mucosa and recently identified in the respiratory tract (Kim, D.Y, et al., 2011), are considered the gateway of the initial immune response because they are constantly binding and taking up soluble and inert antigens as well as commensals and pathogens. To determine how M cells contribute to the generation of an appropriate immune response against an invading pathogen, we investigated the

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35

Rochereau, Nicolas, Vincent Pavot, Bernard Verrier, et al. "Delivery of antigen to nasal-associated lymphoid tissue microfold cells through secretory IgA targeting local dendritic cells confers protective immunity." Journal of Allergy and Clinical Immunology 137, no. 1 (2016): 214–22. http://dx.doi.org/10.1016/j.jaci.2015.07.042.

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36

Maharjan, Sushila, Bijay Singh, Tao Jiang, et al. "Systemic administration of RANKL overcomes the bottleneck of oral vaccine delivery through microfold cells in ileum." Biomaterials 84 (April 2016): 286–300. http://dx.doi.org/10.1016/j.biomaterials.2016.01.043.

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37

Gibb, Matthew, Sahar H. Pradhan, Marina R. Mulenos, et al. "Characterization of a Human In Vitro Intestinal Model for the Hazard Assessment of Nanomaterials Used in Cancer Immunotherapy." Applied Sciences 11, no. 5 (2021): 2113. http://dx.doi.org/10.3390/app11052113.

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There is momentum in biomedical research to improve the structure and function of in vitro intestinal models that better represent human biology. To build a more comprehensive model, three human cell-types were co-cultured and characterized: i.e., HT29-MTX (intestinal mucous-producing goblet cells), Caco-2 (colon epithelial cells), and Raji B (lymphocytes). Raji B cells transformed a subpopulation of Caco-2 epithelial cells into phagocytic and transcytotic immune-supporting microfold cells (M-cells). A suite of bioassays was implemented to investigate steady-state barrier integrity and cellula

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38

Nochi, Tomonori, Yoshikazu Yuki, Akiko Matsumura, et al. "A novel M cell–specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses." Journal of Experimental Medicine 204, no. 12 (2007): 2789–96. http://dx.doi.org/10.1084/jem.20070607.

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Mucosally ingested and inhaled antigens are taken up by membranous or microfold cells (M cells) in the follicle-associated epithelium of Peyer's patches or nasopharynx-associated lymphoid tissue. We established a novel M cell–specific monoclonal antibody (mAb NKM 16–2-4) as a carrier for M cell–targeted mucosal vaccine. mAb NKM 16–2-4 also reacted with the recently discovered villous M cells, but not with epithelial cells or goblet cells. Oral administration of tetanus toxoid (TT)– or botulinum toxoid (BT)–conjugated NKM 16–2-4, together with the mucosal adjuvant cholera toxin, induced high-le

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39

Rios, Daniel, Kathryn Knoop, Nachiket Kumar, et al. "Conditional deletion of RANK in intestinal epithelial cells of mice results in loss of Peyer’s patch M cells and impaired acquisition of orally delivered antigen (49.2)." Journal of Immunology 188, no. 1_Supplement (2012): 49.2. http://dx.doi.org/10.4049/jimmunol.188.supp.49.2.

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Abstract Microfold (M) cells are antigen-sampling intestinal epithelial cells found in the follicle-associated epithelium (FAE) of Peyer’s patches (PPs). M cells initiate mucosal immune responses by transcytosis of particulate antigens for delivery to antigen-presenting cells that traffic through the intraepithelial pocket of M cells. We previously showed that RANKL from stromal cells in the subepithelial dome of PPs is necessary and sufficient for inducing M cell differentiation. To determine how selective loss of intestinal M cells affects host immune responses to antigens encountered in the

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40

Lai, Nicole Y., Melissa A. Musser, Felipe A. Pinho-Ribeiro, et al. "Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense." Cell 180, no. 1 (2020): 33–49. http://dx.doi.org/10.1016/j.cell.2019.11.014.

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41

Qin, Da, Ying Li, Xiaoyan Chen, et al. "Secretory IgA-ETEC F5 Immune Complexes Promote Dendritic Cell Differentiation and Prime T Cell Proliferation in the Mouse Intestine." Life 13, no. 9 (2023): 1936. http://dx.doi.org/10.3390/life13091936.

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Although secretory IgA (SIgA) is the dominant antibody in mucosal secretions, the capacity of the SIgA–antigen complex to prime the activation of dendritic cells (DCs) and T cells in the intestinal epithelium is not well understood. To this end, the SIgA–ETEC F5 immune complexes (ICs) were prepared via Ni-NTA pull-down. After injecting the ICs into the intestines of SPF BALB/c mice, most ICs were observed in the Peyer’s patch (PP). We established a microfold (M) cell culture model in vitro for transport experiments and the inhibition test. To evaluate the priming effect of mucosal immunity, we

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42

Lin, Sisi, Subhajit Mukherjee, Juanjuan Li, Weiliang Hou, Chao Pan, and Jinyao Liu. "Mucosal immunity–mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer’s patches." Science Advances 7, no. 20 (2021): eabf0677. http://dx.doi.org/10.1126/sciadv.abf0677.

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Methods capable of maintaining gut microbiota homeostasis to prevent bacterial translocation and infection under external threats are critical for multiple facets of human health but have been rarely reported. Here, we describe the elicitation of mucosal immunity to modulate the gut microbiota by oral delivery of living probiotics into Peyer’s patches. Probiotics are individually camouflaged within a yeast membrane, on which the embedded β-glucan can facilitate the phagocytosis of microfold cells that locate in the intestinal epithelium. The delivery of probiotics into lymphoid follicles after

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43

Gonzalez-Hernandez, Mariam B., Thomas Liu, Luz P. Blanco, Heather Auble, Hilary C. Payne, and Christiane E. Wobus. "Murine Norovirus Transcytosis across anIn VitroPolarized Murine Intestinal Epithelial Monolayer Is Mediated by M-Like Cells." Journal of Virology 87, no. 23 (2013): 12685–93. http://dx.doi.org/10.1128/jvi.02378-13.

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Noroviruses (NoVs) are the causative agent of the vast majority of nonbacterial gastroenteritis worldwide. Due to the inability to culture human NoVs and the inability to orally infect a small animal model, little is known about the initial steps of viral entry. One particular step that is not understood is how NoVs breach the intestinal epithelial barrier. Murine NoV (MNV) is the only NoV that can be propagatedin vitroby infecting murine macrophages and dendritic cells, making this virus an attractive model for studies of different aspects of NoV biology. Polarized murine intestinal epithelia

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44

Knoop, Kathryn, Betsy Butler, Nachiket Kumar, and Ifor Williams. "Differentiation of Peyer’s patch M cells does not require signals from B cells: evidence from a mouse model of acute antibody-mediated depletion of B cells (90.1)." Journal of Immunology 184, no. 1_Supplement (2010): 90.1. http://dx.doi.org/10.4049/jimmunol.184.supp.90.1.

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Abstract Microfold (M) cells are antigen-sampling cells in the epithelium covering Peyer’s patches (PP) and other mucosal lymphoid tissues. The previously demonstrated reduction in the number of PP M cells in B cell deficient mice (e.g. JH null and muMT models) led to a model proposing that B cells provide critical signals supporting M cell differentiation, but the specific B cell-derived factors involved in this process remain to be identified. We used an alternate model of acute antibody-mediated B cell depletion in human CD20 transgenic mice to reassess the role of B cells in PP M cell diff

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45

Vilander, Allison C., Kimberly Shelton, Alora LaVoy, and Gregg A. Dean. "Expression of E. coli FimH Enhances Trafficking of an Orally Delivered Lactobacillus acidophilus Vaccine to Immune Inductive Sites via Antigen-Presenting Cells." Vaccines 11, no. 7 (2023): 1162. http://dx.doi.org/10.3390/vaccines11071162.

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The development of lactic acid bacteria as mucosal vaccine vectors requires the identification of robust mucosal adjuvants to increase vaccine effectiveness. The E. coli type I fimbriae adhesion protein FimH is of interest as a mucosal adjuvant as it targets microfold (M) cells enhancing vaccine uptake into Peyer’s patches and can activate the innate immune system via Toll-like receptor (TLR) 4 binding. Here, we displayed the N-terminal domain of FimH on the surface of a Lactobacillus acidophilus vaccine vector and evaluated its ability to increase uptake of L. acidophilus into Peyer’s patches

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46

Qin, Yumei, Salin Raj Palayyan, Xin Zheng, Shiyi Tian, Robert F. Margolskee, and Sunil K. Sukumaran. "Type II taste cells participate in mucosal immune surveillance." PLOS Biology 21, no. 1 (2023): e3001647. http://dx.doi.org/10.1371/journal.pbio.3001647.

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The oral microbiome is second only to its intestinal counterpart in diversity and abundance, but its effects on taste cells remains largely unexplored. Using single-cell RNASeq, we found that mouse taste cells, in particular, sweet and umami receptor cells that express taste 1 receptor member 3 (Tas1r3), have a gene expression signature reminiscent of Microfold (M) cells, a central player in immune surveillance in the mucosa-associated lymphoid tissue (MALT) such as those in the Peyer’s patch and tonsils. Administration of tumor necrosis factor ligand superfamily member 11 (TNFSF11; also known

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Jia, Zhengyang, Anthony Wignall, Clive Prestidge, and Benjamin Thierry. "An ex vivo investigation of the intestinal uptake and translocation of nanoparticles targeted to Peyer’s patches microfold cells." International Journal of Pharmaceutics 594 (February 2021): 120167. http://dx.doi.org/10.1016/j.ijpharm.2020.120167.

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Zhao, Ya, Ping Li, Xiaoshuang Wang, Yayun Wu, Lijuan Liu, and Ruizhi Zhao. "A novel pectin polysaccharide from vinegar-baked Radix Bupleuri absorbed by microfold cells in the form of nanoparticles." International Journal of Biological Macromolecules 266 (May 2024): 131096. http://dx.doi.org/10.1016/j.ijbiomac.2024.131096.

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Hondo, Tetsuya, Takashi Kanaya, Ikuro Takakura, et al. "Cytokeratin 18 is a specific marker of bovine intestinal M cell." American Journal of Physiology-Gastrointestinal and Liver Physiology 300, no. 3 (2011): G442—G453. http://dx.doi.org/10.1152/ajpgi.00345.2010.

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Microfold (M) cells in the follicle-associated epithelium (FAE) of Peyer's patches have an important role in mucosal immune responses. A primary difficulty for investigations of bovine M cells is the lack of a specific molecular marker. To identify such a marker, we investigated the expression of several kinds of intermediate filament proteins using calf Peyer's patches. The expression patterns of cytokeratin (CK) 18 in jejunal and ileal FAE were very similar to the localization pattern of M cells recognized by scanning electron microscopy. Mirror sections revealed that jejunal CK18-positive c

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Hosobe, Masayo. "Distribution of ‘dome’ type lymphoid follicles and morphology of microfold cells (M cells) in the human Bauhin's valve, cecum and proximal ascending colon." Medical Electron Microscopy 26, no. 2 (1993): 139–49. http://dx.doi.org/10.1007/bf02348040.

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