Relevant bibliographies by topics / Microglia, CD11c

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Microglia, CD11c'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "Microglia, CD11c"

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Getts, Daniel R., Rachael L. Terry, Meghann Teague Getts, et al. "Ly6c+ “inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis." Journal of Experimental Medicine 205, no. 10 (2008): 2319–37. http://dx.doi.org/10.1084/jem.20080421.

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In a lethal West Nile virus (WNV) model, central nervous system infection triggered a threefold increase in CD45int/CD11b+/CD11c− microglia at days 6–7 postinfection (p.i.). Few microglia were proliferating, suggesting that the increased numbers were derived from a migratory precursor cell. Depletion of “circulating” (Gr1−(Ly6Clo)CX3CR1+) and “inflammatory” (Gr1hi/Ly6Chi/CCR2+) classical monocytes during infection abrogated the increase in microglia. C57BL/6 chimeras reconstituted with cFMS–enhanced green fluorescent protein (EGFP) bone marrow (BM) showed large numbers of peripherally derived
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2

Ramesha, Supriya, Sruti Rayaprolu, Christine A. Bowen, et al. "Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease." Proceedings of the National Academy of Sciences 118, no. 11 (2021): e2013545118. http://dx.doi.org/10.1073/pnas.2013545118.

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Kv1.3 potassium channels, expressed by proinflammatory central nervous system mononuclear phagocytes (CNS-MPs), are promising therapeutic targets for modulating neuroinflammation in Alzheimer’s disease (AD). The molecular characteristics of Kv1.3-high CNS-MPs and their cellular origin from microglia or CNS-infiltrating monocytes are unclear. While Kv1.3 blockade reduces amyloid beta (Aβ) burden in mouse models, the downstream immune effects on molecular profiles of CNS-MPs remain unknown. We show that functional Kv1.3 channels are selectively expressed by a subset of CD11b+CD45+ CNS-MPs acutel
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Cao, Zhijuan, Sean S. Harvey, Terrance Chiang, et al. "Unique Subtype of Microglia in Degenerative Thalamus After Cortical Stroke." Stroke 52, no. 2 (2021): 687–98. http://dx.doi.org/10.1161/strokeaha.120.032402.

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Background and Purpose: Stroke disrupts neuronal functions in both local and remotely connected regions, leading to network-wide deficits that can hinder recovery. The thalamus is particularly affected, with progressive development of neurodegeneration accompanied by inflammatory responses. However, the complexity of the involved inflammatory responses is poorly understood. Herein we investigated the spatiotemporal changes in the secondary degenerative thalamus after cortical stroke, using targeted transcriptome approach in conjunction with histology and flow cytometry. Methods: Cortical ische
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Wlodarczyk, Agnieszka, Nellie Martin, and Trevor Owens. "IGF1 producing CD11c+ microglia emerge during postnatal neurodevelopment." Journal of Neuroimmunology 275, no. 1-2 (2014): 93. http://dx.doi.org/10.1016/j.jneuroim.2014.08.250.

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Manouchehri, Navid, Rehana Z. Hussain, Petra D. Cravens, et al. "CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity." Proceedings of the National Academy of Sciences 118, no. 14 (2021): e2014492118. http://dx.doi.org/10.1073/pnas.2014492118.

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Natalizumab, a humanized monoclonal antibody (mAb) against α4-integrin, reduces the number of dendritic cells (DC) in cerebral perivascular spaces in multiple sclerosis (MS). Selective deletion of α4-integrin in CD11c+ cells should curtail their migration to the central nervous system (CNS) and ameliorate experimental autoimmune encephalomyelitis (EAE). We generated CD11c.Cre+/−ITGA4fl/fl C57BL/6 mice to selectively delete α4-integrin in CD11c+ cells. Active immunization and adoptive transfer EAE models were employed and compared with WT controls. Multiparameter flow cytometry was utilized to
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Parney, Ian F., James S. Waldron, and Andrew T. Parsa. "Flow cytometry and in vitro analysis of human glioma–associated macrophages." Journal of Neurosurgery 110, no. 3 (2009): 572–82. http://dx.doi.org/10.3171/2008.7.jns08475.

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Object To date, glioma immunotherapy has been focused mostly on stimulating antitumor peripheral lymphocyte responses; however, some data suggest that microglia and/or macrophages (not lymphocytes) are the predominant inflammatory cells infiltrating gliomas. To study this hypothesis further, the authors analyzed inflammatory cell infiltrates in fresh human malignant glioma specimens and primary cultures. Methods Single-cell suspensions from fresh operative malignant glioma specimens, obtained by stereotactic localization, were analyzed for CD11b and CD45 by using flow cytometry. A comparison w
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St-Pierre, Marie-Kim, Eva Šimončičová, Eszter Bögi, and Marie-Ève Tremblay. "Shedding Light on the Dark Side of the Microglia." ASN Neuro 12 (January 2020): 175909142092533. http://dx.doi.org/10.1177/1759091420925335.

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Microglia, the resident immune cells of the central nervous system, are not a homogeneous population; their morphology, molecular profile, and even their ultrastructure greatly vary from one cell to another. Recent advances in the field of neuroimmunology have helped to demystify the enigma that currently surrounds microglial heterogeneity. Indeed, numerous microglial subtypes have been discovered such as the disease-associated microglia, neurodegenerative phenotype, and Cd11c-positive developmental population. Another subtype is the dark microglia (DM), a population defined by its ultrastruct
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Anandasabapathy, Niroshana, Gabriel D. Victora, Matthew Meredith, et al. "Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain." Journal of Experimental Medicine 208, no. 8 (2011): 1695–705. http://dx.doi.org/10.1084/jem.20102657.

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Antigen-presenting cells in the disease-free brain have been identified primarily by expression of antigens such as CD11b, CD11c, and MHC II, which can be shared by dendritic cells (DCs), microglia, and monocytes. In this study, starting with the criterion of Flt3 (FMS-like receptor tyrosine kinase 3)-dependent development, we characterize the features of authentic DCs within the meninges and choroid plexus in healthy mouse brains. Analyses of morphology, gene expression, and antigen-presenting function established a close relationship between meningeal and choroid plexus DCs (m/chDCs) and spl
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Ellman, Ditte Gry, Matilda Degn, Minna Christiansen Lund, et al. "Genetic Ablation of Soluble TNF Does Not Affect Lesion Size and Functional Recovery after Moderate Spinal Cord Injury in Mice." Mediators of Inflammation 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/2684098.

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Traumatic spinal cord injury (SCI) is followed by an instant increase in expression of the microglial-derived proinflammatory cytokine tumor necrosis factor (TNF) within the lesioned cord. TNF exists both as membrane-anchored TNF (mTNF) and as cleaved soluble TNF (solTNF). We previously demonstrated that epidural administration of a dominant-negative inhibitor of solTNF, XPro1595, to the contused spinal cord resulted in changes in Iba1 protein expression in microglia/macrophages, decreased lesion volume, and improved locomotor function. Here, we extend our studies using mice expressing mTNF, b
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Herz, Jasmin, Kory R. Johnson, and Dorian B. McGavern. "Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells." Journal of Experimental Medicine 212, no. 8 (2015): 1153–69. http://dx.doi.org/10.1084/jem.20142047.

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Several viruses can infect the mammalian nervous system and induce neurological dysfunction. Adoptive immunotherapy is an approach that involves administration of antiviral T cells and has shown promise in clinical studies for the treatment of peripheral virus infections in humans such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), and adenovirus, among others. In contrast, clearance of neurotropic infections is particularly challenging because the central nervous system (CNS) is relatively intolerant of immunopathological reactions. Therefore, it is essential to develop and mechanistical
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Dissertations / Theses on the topic "Microglia, CD11c"

1

Immig, Kerstin. "Immunphänotypische Charakterisierung CD11c-positiver Zellen des Gehirns im direkten Vergleich zu CD11c-positiven Zellen von Lunge, Leber und Milz." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-200929.

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Bei der vorliegenden Arbeit handelt es sich um eine experimentell durchgeführte Charakterisierung von CD11c-positiven Zellen des Gehirns im direkten Vergleich zu CD11c-positiven Zellen aus Lunge, Leber und Milz. Mittels Konfokal- und Fluoreszenzmikroskopie wurde die Existenz von intraparenchymalen Zellen nachgewiesen, welche den Zellmarker für Dendritische Zellen CD11c exprimieren. Durch die Etablierung einer einheitlichen Isolierungsmethode von CD11c-positiven mononukleären Zellen aus dem Gehirn, Milz, Lunge und Leber, war es uns möglich, diese mittels Durchflusszytometrie, auf die Expression
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2

Morrison, Helena W., and Jessica A. Filosa. "Sex differences in astrocyte and microglia responses immediately following middle cerebral artery occlusion in adult mice." PERGAMON-ELSEVIER SCIENCE LTD, 2016. http://hdl.handle.net/10150/622624.

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Epidemiological studies report that infarct size is decreased and stroke outcomes are improved in young females when compared to males. However, mechanistic insight is lacking. We posit that sex-specific differences in glial cell functions occurring immediately after ischemic stroke are a source of dichotomous outcomes. In this study we assessed astrocyte Ca2+ dynamics, aquaporin 4 (AQP4) polarity, Sloop expression pattern, as well as, microglia morphology and phagocytic marker CD11b in male and female mice following 60 min of middle cerebral artery (MCA) occlusion. We reveal sex differences i
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3

Touriño, Raposo Clara. "Study of the interaction between 3,4 methylenedioximethamphetamine and the endocannabinoid system." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7154.

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La 3,4-metilendioximetamfetamina (MDMA, èxtasi) i el cannabis són dues drogues les quals es consumeixen conjuntament de manera habitual. Malgrat que tots dos compostos presenten propietats reforçant i potencial addictiu, també tenen propietats farmacològiques oposades. La MDMA es una droga psicoestimulant, la qual causa hiperlocomoció, hipertèrmia, resposted de tipus asiogènic i neurotoxicitat. Per altra banda el Δ9-tetrahydrocannabinol (THC), principal compost psicoactiu del cannabis, posseeix efectes relaxants, hipolocomotors, hipotèrmics i neuroprotectors. Els efectes de la MDMA i el T
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4

Immig, Kerstin. "Immunphänotypische Charakterisierung CD11c-positiver Zellen des Gehirns im direkten Vergleich zu CD11c-positiven Zellen von Lunge, Leber und Milz." Doctoral thesis, 2015. https://ul.qucosa.de/id/qucosa%3A14619.

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Bei der vorliegenden Arbeit handelt es sich um eine experimentell durchgeführte Charakterisierung von CD11c-positiven Zellen des Gehirns im direkten Vergleich zu CD11c-positiven Zellen aus Lunge, Leber und Milz. Mittels Konfokal- und Fluoreszenzmikroskopie wurde die Existenz von intraparenchymalen Zellen nachgewiesen, welche den Zellmarker für Dendritische Zellen CD11c exprimieren. Durch die Etablierung einer einheitlichen Isolierungsmethode von CD11c-positiven mononukleären Zellen aus dem Gehirn, Milz, Lunge und Leber, war es uns möglich, diese mittels Durchflusszytometrie, auf die Expression
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Journal articles
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