Relevant bibliographies by topics / Microneedle patch

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  2. Dissertations / Theses
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  4. Conference papers

Academic literature on the topic 'Microneedle patch'

Author: Grafiati
Published: 6 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Microneedle patch"

1

Li, Wei, Jie Tang, Richard N. Terry, Song Li, Aurelie Brunie, Rebecca L. Callahan, Richard K. Noel, Carlos A. Rodríguez, Steven P. Schwendeman, and Mark R. Prausnitz. "Long-acting reversible contraception by effervescent microneedle patch." Science Advances 5, no. 11 (November 2019): eaaw8145. http://dx.doi.org/10.1126/sciadv.aaw8145.

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To increase access to long-acting contraception, we developed a reversible contraceptive microneedle patch that is simple-to-administer, slowly releases contraceptive hormone (levonorgestrel) for >1 month, and generates no biohazardous sharps waste. After manually pressing the patch to skin for 1 min, microneedles rapidly separate from the patch within the skin due to effervescence triggered by contact with skin’s interstitial fluid, as demonstrated in rats and human participants. Long-acting contraception is achieved by formulating microneedles with a biodegradable polymer [poly(lactic-co-glycolic) acid] that slowly releases levonorgestrel for ~1 month in vitro. In rats, the patch maintained levonorgestrel concentration above the human contraceptive threshold level for >1 month, and a placebo microneedle patch was well-tolerated in human participants. Women of reproductive age in three continents demonstrated interest in and preference for long-acting contraception by microneedle patch. These studies indicate that an effervescent microneedle patch could facilitate greater access to long-acting contraception.
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Chan, Victoria, and Steven Wong. "Microneedle patch vaccine." University of Western Ontario Medical Journal 85, no. 2 (November 6, 2016): 69–71. http://dx.doi.org/10.5206/uwomj.v85i2.4149.

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Vaccinations are an important means of controlling communicable diseases, especially in developing countries where patients do not have regular access to adequate healthcare. However, barriers such as cost and lack of resources are particularly problematic in the developing world and limit the adoption of vaccines. Meanwhile, in developed nations, the fear of injections contributes to the growing problem of vaccine avoidance and hesitancy. To address these barriers, a microneedle patch vaccine was recently created by Dr Prausnitz and his research team at the Georgia Institute of Technology in Atlanta, in which application of the patch to the skin allows polymer microneedles containing the vaccine to puncture the epidermis, dissolve, and elicit an immunogenic response. Research using rodent and primate models have demonstrated this technology’s effectiveness, and a human clinical trial using an influenza microneedle patch vaccine is currently being conducted. Future trials are being planned for microneedle patch vaccines against measles and polio as well. This technology’s nearly pain-free administration, portability, and relative ease of delivery can help address patients’ apprehensions to hypodermic needles and lessen administration costs and efforts. While the microneedle patch vaccine is a promising vaccination modality that can potentially be used to overcome the barriers to vaccination, further studies will need to be conducted to determine adverse events. Also, strategies for patient education and potential legal issues will need to be addressed before widespread use of this novel vaccination modality.
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Janphuang, Pattanaphong, Mongkhol Laebua, Chanwut Sriphung, Phatsakon Taweewat, Anan Sirichalarmkul, Kasiphisan Sukjantha, Napatporn Promsawat, et al. "Polymer based microneedle patch fabricated using microinjection moulding." MATEC Web of Conferences 192 (2018): 01039. http://dx.doi.org/10.1051/matecconf/201819201039.

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This paper presents the development of a polymer based microneedle patch for transdermal drug delivery application using plastic microinjection moulding. Design and analysis of the microneedle cavities and mould insert used in the injection moulding process were carried out using Computer-Aided Engineering (CAE) software. A mould insert with low surface roughness was fabricated using Micro Electrical Discharge Machining (μ-EDM). The injection moulding parameters including clamping force, temperature, injection pressure and velocity were characterized in order to obtain the optimum reproducibility. Solid truncated cone microneedles, made of biocompatible polymethyl methacrylate (PMMA), with a round tip radius of 50 μm and 500 μm in height have been realized by microinjection moulding process demonstrating the potential of a low cost, high production efficiency, and suitable for mass production. In addition, a mould insert of cylindrical microneedles fabricated using X-ray LIGA has been proposed.
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Bae, Won-Gyu, Hangil Ko, Jin-Young So, Hoon Yi, Chan-Ho Lee, Dong-Hun Lee, Yujin Ahn, et al. "Snake fang–inspired stamping patch for transdermal delivery of liquid formulations." Science Translational Medicine 11, no. 503 (July 31, 2019): eaaw3329. http://dx.doi.org/10.1126/scitranslmed.aaw3329.

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A flexible microneedle patch that can transdermally deliver liquid-phase therapeutics would enable direct use of existing, approved drugs and vaccines, which are mostly in liquid form, without the need for additional drug solidification, efficacy verification, and subsequent approval. Specialized dissolving or coated microneedle patches that deliver reformulated, solidified therapeutics have made considerable advances; however, microneedles that can deliver liquid drugs and vaccines still remain elusive because of technical limitations. Here, we present a snake fang–inspired microneedle patch that can administer existing liquid formulations to patients in an ultrafast manner (<15 s). Rear-fanged snakes have an intriguing molar with a groove on the surface, which enables rapid and efficient infusion of venom or saliva into prey. Liquid delivery is based on surface tension and capillary action. The microneedle patch uses multiple open groove architectures that emulate the grooved fangs of rear-fanged snakes: Similar to snake fangs, the microneedles can rapidly and efficiently deliver diverse liquid-phase drugs and vaccines in seconds under capillary action with only gentle thumb pressure, without requiring a complex pumping system. Hydrodynamic simulations show that the snake fang–inspired open groove architectures enable rapid capillary force–driven delivery of liquid formulations with varied surface tensions and viscosities. We demonstrate that administration of ovalbumin and influenza virus with the snake fang–inspired microneedle patch induces robust antibody production and protective immune response in guinea pigs and mice.
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Lee, Byeong-Min, Chisong Lee, Shayan Fakhraei Lahiji, Ui-Won Jung, Gehoon Chung, and Hyungil Jung. "Dissolving Microneedles for Rapid and Painless Local Anesthesia." Pharmaceutics 12, no. 4 (April 17, 2020): 366. http://dx.doi.org/10.3390/pharmaceutics12040366.

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Microneedles are emerging drug delivery methods for painless treatment. The current study tested dissolving microneedles containing lidocaine (Li-DMN) for use in local anesthesia. An Li-DMN patch was fabricated by centrifugal lithography with carboxymethyl cellulose as a structural polymer and assessed for physical properties by optical microscopy and a fracture force analyzer. The biocompatibility was evaluated by a histology section in vitro and by ear thickness in vivo. The efficacy of the Li-DMN patch was assessed by electrophysiological recordings in primary cultured sensory neurons in vitro and a von Frey test on rats’ hind paws in vivo. The physical properties of the microneedle showed enough rigidity for transdermal penetration. The maximal capacity of lidocaine-HCl in the Li-DMN patch was 331.20 ± 6.30 µg. The cytotoxicity of the dissolving microneedle to neuronal cells was negligible under an effective dose of lidocaine for 18 h. Electrophysiological recordings verified the inhibitory effect of the voltage-gated sodium channel current by the Li-DMN patch in vitro. A skin reaction to the edema test and histologic analysis of the rats’ ears after application of the Li-DMN patch were negligible. Also, the application of the Li-DMN patch reduced the nocifensive behavior of the rats almost immediately. In conclusion, the dissolving microneedle patch with carboxymethyl cellulose is a promising candidate method for the painless delivery of lidocaine-HCl.
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Quan, Fu-Shi, Yeu-Chun Kim, Jae-Min Song, Hye Suk Hwang, Richard W. Compans, Mark R. Prausnitz, and Sang-Moo Kang. "Long-Term Protective Immunity from an Influenza Virus-Like Particle Vaccine Administered with a Microneedle Patch." Clinical and Vaccine Immunology 20, no. 9 (July 17, 2013): 1433–39. http://dx.doi.org/10.1128/cvi.00251-13.

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ABSTRACTSkin vaccination with influenza virus-like particles (VLPs) using microneedles has been shown to induce protection similar to or better than that induced by intramuscular immunization. In this study, we examined the long-term protective efficacy of influenza (H1N1 A/PR/8/34) VLPs after skin vaccination using microneedle patches coated with the vaccine. Microneedle vaccination of mice in the skin induced 100% protection against lethal challenge infection with influenza A/PR/8/34 virus 14 months after a single vaccine dose. Influenza virus-specific total IgG response and hemagglutination inhibition (HAI) titers were maintained at high levels for over 1 year after microneedle vaccination. Microneedle vaccination also induced substantial levels of lung IgG and IgA antibody responses, and antibody-secreting plasma cells from spleen and bone marrow, as well as conferring effective control of lung viral loads, resulting in complete protection 14 months after vaccination. These strong and long-lasting immune responses were enabled in part by stabilization of the vaccine by formulation with trehalose during microneedle patch fabrication. Administration of the stabilized vaccine using microneedles was especially effective at enabling strong recall responses measured 4 days after lethal virus challenge, including increased HAI and antibody-secreting cells in the spleen and reduced viral titer and inflammatory response in the lung. The results in this study indicate that skin vaccination with VLP vaccine using a microneedle patch provides long-term protection against influenza in mice.
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Chiu, Chui Yu, Hsin Chuan Kuo, Yi Lin, Jeou Long Lee, Yung Kang Shen, and Sheng Jie Kang. "Optimal Design of Microneedles Inserts into Skin by Numerical Simulation." Key Engineering Materials 516 (June 2012): 624–28. http://dx.doi.org/10.4028/www.scientific.net/kem.516.624.

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The purpose of this research is to find the optimal design for biodegradable polymer microneedle patches. Based on the mechanical properties of different skin layers and the failure criterion of the material, this research designs a microneedle of four types and three sizes, then discusses the insertion force and the variation of stress during the process of PLA microneedle insertion into skin by numerical simulation. This research uses the dynamic finite element software ANSYS / LS-DYNA to simulate the processing for PLA microneedle inserts into skin. The master microneedle array was fabricated by the MEMS process. This research uses PDMS to fabricate the mould for microneedles. Finally, a biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated using a PDMS mould micro hot embossing method.
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Liu, Guiqin, Yan Deng, Yi Song, Yi Sui, Juan Cen, Ziyu Shao, Hu Li, and Tao Tang. "Transdermal Delivery of Adipocyte Phospholipase A2 siRNA using Microneedles to Treat Thyroid Associated Ophthalmopathy-Related Proptosis." Cell Transplantation 30 (January 1, 2021): 096368972110106. http://dx.doi.org/10.1177/09636897211010633.

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Thyroid associated ophthalmopathy (TAO) is an organ-specific autoimmune disease occurring in patients with thyroid disease. Patients with TAO-related proptosis is largely due to excessive orbital adipose tissue Adipocyte phospholipase A2 (AdPLA) is one of the most important regulatory factors in adipocyte lipolysis, which may be associated with TAO-related proptosis. Thus, silencing AdPLA by RNA interference may be beneficial for the treatment of TAO. In this study, we sought to evaluate the efficiency of two types of microneedles to deliver siRNAs for silencing AdPLA. Our results showed that AdPLA mRNA was up-regulated in the orbit adipose tissues from TAO patients. Silence of AdPLA by siRNA can reduce lipid accumulation in both human and mouse adipocyte cell lines. Moreover, silence effects of silicon microneedle array patch-based and injectable microneedle device-based siRNA administration were examined at the belly site of the mice, and injectable microneedle device showed higher knockdown efficiency than silicon microneedle array patch. This study sets the stage not only for future treatment of TAO-related proptosis using AdPLA siRNA, but also provides the foundation for targeted siRNA delivery by using microneedles.
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Al-Qallaf, Barrak, Diganta Bhusan Das, Daisuke Mori, and Zhanfeng Cui. "Modelling transdermal delivery of high molecular weight drugs from microneedle systems." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 365, no. 1861 (September 21, 2007): 2951–67. http://dx.doi.org/10.1098/rsta.2007.0003.

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In the past few years, a number of microneedle designs have been proposed for transdermal drug delivery of high molecular weight drugs. However, most of them do not increase the drug permeability in skin significantly. In other cases, designs developed based on certain criteria (e.g. strength of the microneedles) have failed to meet other criteria (e.g. drug permeability in skin, throughputs of the drugs, etc.). It is obvious therefore that in order to determine the ‘optimum’ design of these microneedles, the effect of different factors (e.g. length of the microneedle, surface area of the patch, etc.) along with various transport properties of drug transport behaviour using microneedles should be determined accurately. Appropriate mathematical models for drug transport from these systems into skin have the potential to resolve some of these issues. To address this, a parametric analysis for transdermal delivery of a high molecular weight drug from a microneedle is presented in this paper. The simulations have allowed us to identify the significance of various factors that influence the drug delivery while designing microneedle arrays. A scaling analysis is also done which shows the functional dependence of drug concentration on other variables of skin and microneedle arrays.
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Sadeq, Zainab A. "Microneedle Array Patches: Characterization and in -vitro Evaluation." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 30, no. 1 (June 15, 2021): 66–75. http://dx.doi.org/10.31351/vol30iss1pp66-75.

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Patch in transdermal drug delivery(TDDS) used to overcome the hypodermic drawback, but these patch also have absorption limitation for hydrophilic and macromolecule like peptide and DNA. So that micronized projection have the ability for skin penetration developed named as microneedle. Microneedle drug delivery system is a novel drug delivery to overcome the limitation of TDDS like skin barrier restriction for large molecule. Microneedle patch can penetrate through skin subcutaneous into epidermis, avoiding nerve fiber and blood vessel contact. There are many type of microneedle patch like solid, polymer, hallow, hydrogel forming microneedle and dissolving microneedle with different method of microfabrication
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Dissertations / Theses on the topic "Microneedle patch"

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Edens, William Christopher. "Measles and polio vaccination using a microneedle patch to increase vaccination coverage in the developing world." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52951.

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Despite the existence of effective vaccines for both diseases, measles and poliomyelitis still cause significant worldwide morbidity and mortality. The live-attenuated measles and inactivated polio vaccines are both given using a standard needle and syringe injection. This method of delivery poses many problems for large-scale vaccination campaigns. Microneedles are micron-scale needles which have the potential to overcome many of these hurdles. In the first study, we showed that the measles vaccine could be successfully incorporated into a solid, metal microneedle system which induced potent neutralizing antibody titers after administration into cotton rats. This response was statistically identical to the same dose delivered using a subcutaneous injection. The second study focused on enhancing the stability of the measles vaccine after drying and long-term storage. Using a new assay developed from a measles virus variant engineered to encode for green fluorescent protein, it was determined that a combination of sucrose and threonine provided the highest stabilizing effect. Vaccine mixed with this solution retained more than 90% of its activity after 6 months of storage at 4°C and 25°C. The third study involved the incorporation of the measles vaccine into a dissolving microneedle patch. These patches were used to vaccinate rhesus macaques and the immune response was found to be statistically identical to the same dose delivered by syringe injection. Furthermore, after creation and storage, these patches retained 100% of their infectivity after 2 months at 4°C and 25°C. The final study attempted to create a dissolving microneedle patch containing a full dose of the inactivated polio vaccine. These patches were then used to deliver a full dose of IPV into the skin of a rhesus macaque. This delivery method produced neutralizing antibody titers to IPV type 1 and 2 that were statistically identical to the same dose delivered using a needle and syringe. Overall, these studies show that the microneedle patch was a safe, simple and effective method for measles and polio vaccination. This delivery platform has the potential to overcome many of the hurdles that currently stand in the way of measles elimination and polio eradication.
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Lee, Li-Yu, and 李立宇. "The Study of Dissolving Microneedle Patch for Androgenetic Alopecia." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/t25aas.

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碩士
國立清華大學
化學工程學系所
105
Microneedle patch is a painless transdermal drug delivery method, It could solve some problems in traditional drug delivery such as digestive system causing drug metabolism and subcutaneous injection causing some side effects. Coating drug on or loading drug in microneedle can carry active ingredient through stratum corneum, also can contol dose well when microneedle patch apply on localized topical area. We used hyaluronic acid to fabricate dissolvable microneedle patch and encapsulated minoxidil into microneedles. Minoxdil is a drug for exterior use that can be used to treat androgenetic alopecia, but related commercial products have some shortcomings, for example, propylene glycol which is used to soften stratum corneum cause skin allergic reaction, comparing chemical promotion, microneedle patch provide physical way to make drugs through nature barrier of skin. In this research, we designed a two-step process to fabricate microneedle patch, that can effectively reduce drug waste. And gentle production process used could maintain drug activity well. We also do in-vitro test on cadaver skins to make sure patch has enough mechanical strength to penetrate stratum corneum. In the release test and animal test, we found microneedle patch has higher delivery efficiency than tradition way. In this study, we may conclude that germinal MNs patch has potential to commercialization. Keywords ─ dissolving microneedles; Androgenetic alopecia; minoxidil transdermal drug delivery
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Hsieh, Chung-Min, and 謝仲閔. "Analysis on the Drying Process for Making a Microneedle Patch." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/36pq7u.

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TzuHui, HUANG, and 黃資惠. "Localized Two Steps Controlled Released Microneedle Patch for Transdermal Drug Delivery." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/53948602792555668750.

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碩士
國立清華大學
奈米工程與微系統研究所
101
Hyperpigmentation is a hypermelanosis occurring in all skin types and results from the overproduction of melanin or an irregular dispersion of pigment after cutaneous inflammation. Patients with hyperpigmentation can have a significant psychosocial impact on skin-of-color patients, including Asian. There are a variety of medications and procedures added to photoprotection cream that can safely and effectively treat hyperpigmentation. A fixed triple combination cream, containing 4% Hydroquinone (HQ), 0.05% Tretinoin (Vit. A acid), and 0.01% fluocinolone acetonide (steroids), called Tri-Luma from Galderma Laboratories (Fort Worth, TX), offer maximal efficacy for clinical trial. HQ and Vit. A Acid can inhibit the formation of melanin by inhibiting the tyrosinase in melanocytes in the bottom of epidermis layer. Fluocinolone acetone, the steroids can eliminate the irritation caused by hydroquinone or tretinoin. However, clinical study showed that over 87.5% of patients were noted to have side-effects with cream treatment because of the Hydroquinone cytotoxicity and slow degradation. In this study, we proposed a new design of microneedles patch with different height for different skin layer to treat hyperpigmentation. For the deeper melanocyte in the bottom of epidermis layer, longer microneedle in the center of patch served as a fast released carrier loaded active ingredient HQ and Vit. A Acid for drug localization and fast metabolism to decrease HQ cytotoxicity. The shorter microneedle contained fluocinolone acetonide to dissolve gently in the keratinocytes layer to eliminate the irritation. In vitro and in vivo study showed the feasibility of hyperpigmentation treatment. This approach could be a potential technology enabling direct transcutaneous delivery in clinical applications.
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Hsiang-HanTseng and 曾湘涵. "Investigation of membrane filtration for fabrication of flexible, dissolvable polymer microneedle patch." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/492efg.

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碩士
國立成功大學
化學工程學系
104
In this study, we proposed and demonstrated that the dissolvable and flexible polymer MNs patch can be fabricated by microfiltration. The polydimethylsiloxane (PDMS) mold with funnel-like cavities was first created, which was placed on top of a filter paper. A droplet of polyvinylpyrrolidone (PVP) solution was dispensed on the mold, followed by applying vacuum. Different parameters such as solution concentrations, filtration time, molecular weight of the polymer, pore size of the membrane were discussed. It was found that PVP microneedles can be fabricated by filtration method within 1 hr. In addition, the MNs as fabricated have sufficient mechanical strength to penetrate the porcine skin with the penetration depth around 250 µm. Dissolution of the PVP microneedles in 10 wt% gelatin was also monitored and the distribution of R6G inside gelatin can be described by Fick’s 2nd law.
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HUANG, MIN-HUI, and 黃敏惠. "Evaluation of dissolving microneedle array patch for transdermal delivery of antipsychotic drugs." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/x264t5.

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碩士
元培醫事科技大學
生物科技暨製藥技術系碩士班
107
Drugs developed as transdermal delivery dosage form have advantages of easy to carry, ease for administration, avoiding first pass effect as well as providing topical or systemic therapeutic. However, low bioavailability is always occurred due to the hindrance of stratum corneum that is existed on the outer surface of skin. Strategies that could overcome the physiological barrier of stratum corneum on the outer surface of skin and harmless to tissue are the most important issues. In this study, we have developed a dissolving microneedle array patch with 10×10 microneedles on 8 mm×8 mm area. The shape of each microneedle was tetrahedral cone with 100×100 μm2 of basal area and 300 μm in length. The physical parameters with regard to hardness was measured as 24.93±3.12 N. The drug loaded patch with this hardness was confirmed could pierce the stratum corneum of the nude mouse skin. The melting point of model drug loaded in microneedle array patch was analyzed by differential scanning calorimetry (DSC). Similar melting point at 147-148 ℃ was observed when comparing Aripiprazole alone to formulated one. In addition, the results of Fourier-transform infrared spectroscope (FTIR) evaluation showed the wavenumber of model drug did not shift after formulated with patch excipients represented there no structure interaction between drug and excipients molecules. Loaded model drug may follow zero order released with the release rate of 244.31±30.71 ng/hr. The results of in vitro skin permeation study using Franz cell showed significant increase in apparent permeability coefficient of model drug loaded in microneedle array patch for 1.93×10-8 cm/sec compared to model drug alone. After patching drug loaded microneedle array on nude mice skin, blood samples were quantified by HPLC analysis. The results showed model drug behave sustained release properties. The pharmacokinetic parameters were analyzed with the non-compartment model and the conpartment model by using PK solver software. The results showed two-compartment mode was the best match. In vivo tissue analysis, the results show that the drug is distributed to various tissues, it also conforms to the two-compartment mode in the compartmental mode and the blood-tissue barrier system. In addition, model drug was quantified to distributed in the heart, lung, liver, spleen, stomach, kidney, duodenum, testis, brain and spinal cord. Among those issues, model drug showed relative slow distribution to blood-tissue barrier existed tissues including brain, spinal cord and testis.
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Silvestre, Sara Isabel Laiginha. "Biopolymer based microneedles patch by laser technology for biomedical applications." Master's thesis, 2018. http://hdl.handle.net/10362/50168.

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One of the most important issues in creating new drug delivery methods is improving drug permeation into the skin. Therefore, many techniques have been proposed, such as oral administration, intradermal vaccines, transdermal patches, among others, but all of them present several limitations. In the past few years, a new effective, innovative and safe drug delivery system was proposed. This technology is named as microneedles (MNs) and it is a hybrid combination of hypodermic injections and transdermal drug delivery systems, which consists in micro-scale needles that can pierce the skin by a simple, minimally invasive and painless route, enabling to transport drugs and macromolecules into the human body. This dissertation reports the development of a biopolymer-based microneedle patch, using biodegradable and biocompatible polymers, polylactic acid (PLA) and poly(hydroxybutyrate-co-hydroxyvalerate) (P(HB-co-HV)), through a low-cost and maskless laser technology. The laser technology was used to engrave specific patterns on a substrate that served as mold for the MNs production. The best results were obtained with a laser power of 30 W at 0.15 m/s, with the spiral model as pattern. The respective MNs had a length of 0.69 mm and a diameter of 0.33 mm, ideal for painless penetration of skin. Moreover, P(HB-co-HV) demonstrated a higher mechanical stability than commercial PLA, confirming its promising use as MNs biomaterial.
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Cheng, Yi-Chi, and 鄭亦棋. "Predicting the mechanical properties of PMVEMA reinforced PVA for microneedle patch: A molecular mechanics study." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/5cx589.

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碩士
國立中山大學
機械與機電工程學系研究所
107
Dissolving microneedles (DMNs)-based vaccination with tumor antigens has been considered as an attractive method for transcutaneous immunization due to its superior ability to deliver vaccines through the stratum corneum (SC) in a minimally invasive manner, which subsequently induce adaptive antitumor immunity. In this study, molecular simulations (MD) were carried out to investigate the mechanical properties of poly(vinyl alcohol) (PVA, good water-solubility) and poly(methyl vinyl ether-alt-maleic anhydride) (PMVEMA, high mechanical strength) blends with different fractions by the uniaxial tension simulation. For validating the accuracy of Dreiding potential for these two polymers, the density and Hildebrand solubility parameter of them were first predicted by MD simulation at the first stage. The values of density and Hildebrand solubility parameter exhibit good agreement with the corresponding experimental results, indicating the reliability of Dreiding potential for these polymers. For the simulation results indicating the number density of H-bonds between the PVA and PMVEMA at 50% PMVEMA is the highest, which can significantly enhance the mechanical strength of pristine PVA. For the further experimentally validated, the evidences from mechanical strength, solubility, and in vitro porcine skin penetration tests are consistent with our simulation predictions. In addition, our results presented that delivery of Ovalbumin (OVA) using MN patches fabricated with the formulation of PVA/PMVEMA(50%) provided even stronger immune responses. Based on this molecular simulation procedure, the optimal fraction of PVA/PMVEMA composite with the highest mechanical property can be fast predicted to reduce the research time and costs in related experiment.
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Laszlo, Elise. "Développement de timbres de microaiguilles polymériques superabsorbantes pour le prélèvement indolore de liquide interstitiel dermique." Thesis, 2020. http://hdl.handle.net/1866/25211.

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Le liquide interstitiel est aujourd’hui considéré comme un candidat prometteur comme alternative, ou complément, à l’analyse sanguine pour la quantification de biomarqueurs. Localisé notamment dans la peau, sa composition demeure peu décrite dans la littérature. Cela peut s’expliquer par le fait que le prélèvement de liquide interstitiel reste problématique. En effet, les méthodes d’extraction actuelles sont chronophages, douloureuses et conduisent au prélèvement de volumes très faibles ne permettant pas toujours une analyse subséquente. L’utilisation de timbres de microaiguilles conçus en hydrogel superabsorbant représente une solution indolore, rapide et efficace pour le prélèvement du liquide interstitiel. Un premier type de timbre a été conçu par photopolymérisation, un processus de fabrication caractérisé par sa rapidité. Ce type de timbre de microaiguilles présente une capacité d’absorption très élevée et peut trouver une application dans l’élaboration des profils protéomique, métabolomique et lipidomique du liquide interstitiel dermique. Le second type de timbres de microaiguilles est obtenu par chauffage d’une formulation contenant des polymères superabsorbants. Ce procédé s’avère plus long mais conduit à un hydrogel superabsorbant riche en groupements chimiques permettant d’envisager une fonctionnalisation pour la capture et la détection in situ de biomarqueurs spécifiques du liquide interstitiel dermique. In fine, les timbres de microaiguilles développés pourraient donc permettre d’approfondir notre connaissance de la composition du liquide interstitiel; mais laissent également entrevoir la possibilité de développer des dispositifs médicaux portables permettant le diagnostic, ou la surveillance, rapide et indolore de certaines pathologies. Ces dispositifs pourraient diminuer les coûts normalement associés à ces pratiques et améliorer la prise en charge des patients. C’est le cas notamment de l’insuffisance cardiaque, dont la gestion pourrait être considérablement facilitée par le suivi à domicile du biomarqueur NT-proBNP.
Nowadays, interstitial fluid is considered a valid alternative for blood analysis and biomarker monitoring. However, its composition is scarcely described in the literature. Notably located in the skin, its collection remains a challenge as current methods are time-consuming, painful and the extracted volume limits subsequent analysis. Here we put forward the use of superabsorbant hydrogel-based microneedle patches to enable a painless, rapid and efficient sampling of dermal interstitial fluid. A first kind of microneedle patch was obtained using UV-curing, a rapid fabrication process. This type of microneedle patch enables the collection of a high volume of liquid and can therefore be utilized for subsequent proteomic, metabolomic and lipidomic analyses of the dermal interstitial fluid that had been extracted in a painless fashion. The second class of microneedle patch developed was fabricated from superabsorbant polymers using heating. Although time consuming, this process produced hydrogel-based microneedle patches that could be functionalized for the in situ detection of specific biomarkers in the dermal interstitial fluid. In fine, the aforementioned microneedle patches have the potential to broaden our understanding of the interstitial fluid composition, as well as be integrated in novel portable biosensing devices for a rapid and painless diagnosis, or for the monitoring of certain medical conditions. For example, quantifying the NT-proBNP biomarker in the dermal interstitial fluid could significantly improve the quality of life of heart failure patients.
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10

Kuan-YingLai and 賴冠穎. "Sustained delivery of vaccine using patch-dissolvable chitosan microneedles for transcutaneous immunization." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/69077237362825632794.

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Abstract:
碩士
國立成功大學
化學工程學系碩博士班
101
Currently developed microneedles for vaccine delivery always rapidly release encapsulated materials. Prolonged antigen release is highly desirable to induce a “depot” effect, which can result in a more potent and persistent immune response. This study introduces an integrated microneedle system, composed of embeddable chitosan microneedles with a dissolvable poly(vinyl pyrrolidone)/poly(vinyl alcohol) (PVP/PVA) supporting array, for complete and sustained delivery of encapsulated antigens to the skin. The strong PVP/PVA supporting array can provide mechanical strength to fully insert the microneedles into the skin. When inserted into rat and porcine skin, the skin interstitial fluid quickly dissolved the supporting array and chitosan microneedles were left within the skin for sustained drug delivery. The microneedle penetration depth was approximately 650-700 m (i.e. the total length of the microneedle), which is beneficial for targeted delivery of antigens to antigen-presenting cells in the epidermis and dermis. When the OVA-loaded microneedles were embedded in rat skin in vivo, histological examination showed that the microneedles gradually degraded and prolonged OVA releasing at the insertion sites for up to 28 days. Compared to traditional intramuscular immunization (500 g OVA), rats immunized by a lower microneedle dose of 200 g OVA showed a significantly higher OVA-specific antibody response on the second week which lasted for at least 8 weeks. Additionally, mice vaccinated with vaccine-loaded microneedles produced 2.5-fold influenza-specific antibody responses compared with those induced by the intramuscular immunization after 12 weeks. These results suggest that embeddable chitosan microneedles are a promising depot for extended delivery of encapsulated antigens, which may provide sustained immune stimulation and improve immunogenicity.
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Book chapters on the topic "Microneedle patch"

1

Kochhar, Jaspreet Singh, Justin J. Y. Tan, Yee Chin Kwang, and Lifeng Kang. "Microneedle Patch to Deliver Collagen Through the Skin." In Microneedles for Transdermal Drug Delivery, 81–94. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-15444-8_6.

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Kochhar, Jaspreet Singh, Justin J. Y. Tan, Yee Chin Kwang, and Lifeng Kang. "Microneedle Patch for Fast Onset and Long-Lasting Delivery of Painkillers." In Microneedles for Transdermal Drug Delivery, 67–80. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-15444-8_5.

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3

Dardano, P., A. Caliò, V. Di Palma, M. F. Bevilacqua, A. Di Matteo, and L. De Stefano. "Multianalyte Biosensor Patch Based on Polymeric Microneedles." In Lecture Notes in Electrical Engineering, 73–81. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55077-0_10.

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Conference papers on the topic "Microneedle patch"

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Jin, Chun Yan, Man Hee Han, Seung S. Lee, and Yo Han Choi. "Usefulness verification of biocompatible microneedle patch for transdermal drug delivery." In 2009 IEEE Sensors. IEEE, 2009. http://dx.doi.org/10.1109/icsens.2009.5398473.

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2

Tayyaba, Shahzadi, Muhammad Waseem Ashraf, Nitin Afzulpurkar, and Muhammad Khaleeq ur Rahman. "Design, Simulation and Development of Gold Microneedles Patch." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-64443.

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Technological advancements are essential for all fields of life particularly in health discipline to test and analyze the biological and biomedical samples. Biological micro electromechanical system (Bio-MEMS) based healthcare technologies are handy to make human life comfortable and snug by ease of use, eradicating pain, reducing risk of diseases, improving diagnosis process and treatments techniques. In this study the design, simulation and development of piezoelectricaly actuated microfluidic device (gold needle patch) has been presented. The simulation of skin insertion using gold needle into skin to study the effects of skin piercing and optimize the design of needle has been conducted in ansys autodyne by making 3D model with applied force 0.4 to 0.9 N at the tip area of needle. The microfluidic analysis of 3×3 microneedle patch has been carry out in ansys workbench using computational fluid dynamic (CFX) environment. The maximum velocity 2.015 e4 m/Sec has been achieved. After the successful development of gold needles patch, the fluid transport and insertion test of piezoelectricaly actuated patch also has been conducted using chicken skin.
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Li, Tingyu, Junshi Li, Zhongyan Wang, Yingjie Ren, Yufeng Jin, Dong Huang, Qining Wang, and Zhihong Li. "A Dissolvable Microneedle Patch Based on Medical Adhesive Tape for Transdermal Drug Delivery." In 2021 IEEE 34th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2021. http://dx.doi.org/10.1109/mems51782.2021.9375171.

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Wang, Zijing, Keyin Liu, Nan Qin, and Tiger H. Tao. "A Silk-Based Microneedle Patch for Controlled Multi-Drug Delivery in Glioma Treatment." In 2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers). IEEE, 2021. http://dx.doi.org/10.1109/transducers50396.2021.9495404.

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Kharbikar, B. N., H. Kumar, R. Gope, N. Shriyan, D. Dave, and R. Srivastava. "Prophylactic (cold-chain independent) vaccination facilitated by microneedle patch of reinforced polymer with vaccine loaded silk nanoparticles." In Proceedings of the International Conference on Nanotechnology for Better Living. Singapore: Research Publishing Services, 2016. http://dx.doi.org/10.3850/978-981-09-7519-7nbl16-rps-219.

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Kharbikar, Bhushan N., Harish Kumar S., Sindhu Kr., and Rohit Srivastava. "Hollow silicon microneedle array based trans-epidermal antiemetic patch for efficient management of chemotherapy induced nausea and vomiting." In SPIE Micro+Nano Materials, Devices, and Applications, edited by Benjamin J. Eggleton and Stefano Palomba. SPIE, 2015. http://dx.doi.org/10.1117/12.2207407.

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Wu, Xiaobin, Nobuyuki Takama, and Beomjoon Kim. "A biodegradable microneedles – trapezoidal micropatterned patch in the LED therapy." In 2019 IEEE CPMT Symposium Japan (ICSJ). IEEE, 2019. http://dx.doi.org/10.1109/icsj47124.2019.8998629.

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Dardano, P., I. Rea, L. De Stefano, A. Calio, and J. Politi. "Optically Controlled Drug Delivery System based on Porous Silicon and Microneedles patch." In 2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM). IEEE, 2015. http://dx.doi.org/10.1109/nanofim.2015.8425359.

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Luo, Kaifeng, Rie Kinoshita, Teru Okitsu, Libo Wu, Nobuyuki Takama, Beomjoon Kim, and Yutaka Maruoka. "Modeling of Stomatitis in Rats and novel Treatment using Microneedles-based Patch." In 2018 IEEE CPMT Symposium Japan (ICSJ). IEEE, 2018. http://dx.doi.org/10.1109/icsj.2018.8602776.

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Bao, Leilei, Nobuyuki Takama, and Beomjoon Kim. "A Fabrication of Whole-dissovable Microneedles Patch in Larger Area for Transdermal Drug Delivery." In 2019 IEEE CPMT Symposium Japan (ICSJ). IEEE, 2019. http://dx.doi.org/10.1109/icsj47124.2019.8998676.

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