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Journal articles on the topic 'Microneedle patch'

Author: Grafiati

Published: 6 June 2021

Last updated: 1 February 2022

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1

Li, Wei, Jie Tang, Richard N. Terry, Song Li, Aurelie Brunie, Rebecca L. Callahan, Richard K. Noel, Carlos A. Rodríguez, Steven P. Schwendeman, and Mark R. Prausnitz. "Long-acting reversible contraception by effervescent microneedle patch." Science Advances 5, no. 11 (November 2019): eaaw8145. http://dx.doi.org/10.1126/sciadv.aaw8145.

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To increase access to long-acting contraception, we developed a reversible contraceptive microneedle patch that is simple-to-administer, slowly releases contraceptive hormone (levonorgestrel) for >1 month, and generates no biohazardous sharps waste. After manually pressing the patch to skin for 1 min, microneedles rapidly separate from the patch within the skin due to effervescence triggered by contact with skin’s interstitial fluid, as demonstrated in rats and human participants. Long-acting contraception is achieved by formulating microneedles with a biodegradable polymer [poly(lactic-co-glycolic) acid] that slowly releases levonorgestrel for ~1 month in vitro. In rats, the patch maintained levonorgestrel concentration above the human contraceptive threshold level for >1 month, and a placebo microneedle patch was well-tolerated in human participants. Women of reproductive age in three continents demonstrated interest in and preference for long-acting contraception by microneedle patch. These studies indicate that an effervescent microneedle patch could facilitate greater access to long-acting contraception.

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2

Chan, Victoria, and Steven Wong. "Microneedle patch vaccine." University of Western Ontario Medical Journal 85, no. 2 (November 6, 2016): 69–71. http://dx.doi.org/10.5206/uwomj.v85i2.4149.

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Vaccinations are an important means of controlling communicable diseases, especially in developing countries where patients do not have regular access to adequate healthcare. However, barriers such as cost and lack of resources are particularly problematic in the developing world and limit the adoption of vaccines. Meanwhile, in developed nations, the fear of injections contributes to the growing problem of vaccine avoidance and hesitancy. To address these barriers, a microneedle patch vaccine was recently created by Dr Prausnitz and his research team at the Georgia Institute of Technology in Atlanta, in which application of the patch to the skin allows polymer microneedles containing the vaccine to puncture the epidermis, dissolve, and elicit an immunogenic response. Research using rodent and primate models have demonstrated this technology’s effectiveness, and a human clinical trial using an influenza microneedle patch vaccine is currently being conducted. Future trials are being planned for microneedle patch vaccines against measles and polio as well. This technology’s nearly pain-free administration, portability, and relative ease of delivery can help address patients’ apprehensions to hypodermic needles and lessen administration costs and efforts. While the microneedle patch vaccine is a promising vaccination modality that can potentially be used to overcome the barriers to vaccination, further studies will need to be conducted to determine adverse events. Also, strategies for patient education and potential legal issues will need to be addressed before widespread use of this novel vaccination modality.

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3

Janphuang, Pattanaphong, Mongkhol Laebua, Chanwut Sriphung, Phatsakon Taweewat, Anan Sirichalarmkul, Kasiphisan Sukjantha, Napatporn Promsawat, et al. "Polymer based microneedle patch fabricated using microinjection moulding." MATEC Web of Conferences 192 (2018): 01039. http://dx.doi.org/10.1051/matecconf/201819201039.

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This paper presents the development of a polymer based microneedle patch for transdermal drug delivery application using plastic microinjection moulding. Design and analysis of the microneedle cavities and mould insert used in the injection moulding process were carried out using Computer-Aided Engineering (CAE) software. A mould insert with low surface roughness was fabricated using Micro Electrical Discharge Machining (μ-EDM). The injection moulding parameters including clamping force, temperature, injection pressure and velocity were characterized in order to obtain the optimum reproducibility. Solid truncated cone microneedles, made of biocompatible polymethyl methacrylate (PMMA), with a round tip radius of 50 μm and 500 μm in height have been realized by microinjection moulding process demonstrating the potential of a low cost, high production efficiency, and suitable for mass production. In addition, a mould insert of cylindrical microneedles fabricated using X-ray LIGA has been proposed.

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4

Bae, Won-Gyu, Hangil Ko, Jin-Young So, Hoon Yi, Chan-Ho Lee, Dong-Hun Lee, Yujin Ahn, et al. "Snake fang–inspired stamping patch for transdermal delivery of liquid formulations." Science Translational Medicine 11, no. 503 (July 31, 2019): eaaw3329. http://dx.doi.org/10.1126/scitranslmed.aaw3329.

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A flexible microneedle patch that can transdermally deliver liquid-phase therapeutics would enable direct use of existing, approved drugs and vaccines, which are mostly in liquid form, without the need for additional drug solidification, efficacy verification, and subsequent approval. Specialized dissolving or coated microneedle patches that deliver reformulated, solidified therapeutics have made considerable advances; however, microneedles that can deliver liquid drugs and vaccines still remain elusive because of technical limitations. Here, we present a snake fang–inspired microneedle patch that can administer existing liquid formulations to patients in an ultrafast manner (<15 s). Rear-fanged snakes have an intriguing molar with a groove on the surface, which enables rapid and efficient infusion of venom or saliva into prey. Liquid delivery is based on surface tension and capillary action. The microneedle patch uses multiple open groove architectures that emulate the grooved fangs of rear-fanged snakes: Similar to snake fangs, the microneedles can rapidly and efficiently deliver diverse liquid-phase drugs and vaccines in seconds under capillary action with only gentle thumb pressure, without requiring a complex pumping system. Hydrodynamic simulations show that the snake fang–inspired open groove architectures enable rapid capillary force–driven delivery of liquid formulations with varied surface tensions and viscosities. We demonstrate that administration of ovalbumin and influenza virus with the snake fang–inspired microneedle patch induces robust antibody production and protective immune response in guinea pigs and mice.

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5

Lee, Byeong-Min, Chisong Lee, Shayan Fakhraei Lahiji, Ui-Won Jung, Gehoon Chung, and Hyungil Jung. "Dissolving Microneedles for Rapid and Painless Local Anesthesia." Pharmaceutics 12, no. 4 (April 17, 2020): 366. http://dx.doi.org/10.3390/pharmaceutics12040366.

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Microneedles are emerging drug delivery methods for painless treatment. The current study tested dissolving microneedles containing lidocaine (Li-DMN) for use in local anesthesia. An Li-DMN patch was fabricated by centrifugal lithography with carboxymethyl cellulose as a structural polymer and assessed for physical properties by optical microscopy and a fracture force analyzer. The biocompatibility was evaluated by a histology section in vitro and by ear thickness in vivo. The efficacy of the Li-DMN patch was assessed by electrophysiological recordings in primary cultured sensory neurons in vitro and a von Frey test on rats’ hind paws in vivo. The physical properties of the microneedle showed enough rigidity for transdermal penetration. The maximal capacity of lidocaine-HCl in the Li-DMN patch was 331.20 ± 6.30 µg. The cytotoxicity of the dissolving microneedle to neuronal cells was negligible under an effective dose of lidocaine for 18 h. Electrophysiological recordings verified the inhibitory effect of the voltage-gated sodium channel current by the Li-DMN patch in vitro. A skin reaction to the edema test and histologic analysis of the rats’ ears after application of the Li-DMN patch were negligible. Also, the application of the Li-DMN patch reduced the nocifensive behavior of the rats almost immediately. In conclusion, the dissolving microneedle patch with carboxymethyl cellulose is a promising candidate method for the painless delivery of lidocaine-HCl.

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6

Quan, Fu-Shi, Yeu-Chun Kim, Jae-Min Song, Hye Suk Hwang, Richard W. Compans, Mark R. Prausnitz, and Sang-Moo Kang. "Long-Term Protective Immunity from an Influenza Virus-Like Particle Vaccine Administered with a Microneedle Patch." Clinical and Vaccine Immunology 20, no. 9 (July 17, 2013): 1433–39. http://dx.doi.org/10.1128/cvi.00251-13.

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ABSTRACTSkin vaccination with influenza virus-like particles (VLPs) using microneedles has been shown to induce protection similar to or better than that induced by intramuscular immunization. In this study, we examined the long-term protective efficacy of influenza (H1N1 A/PR/8/34) VLPs after skin vaccination using microneedle patches coated with the vaccine. Microneedle vaccination of mice in the skin induced 100% protection against lethal challenge infection with influenza A/PR/8/34 virus 14 months after a single vaccine dose. Influenza virus-specific total IgG response and hemagglutination inhibition (HAI) titers were maintained at high levels for over 1 year after microneedle vaccination. Microneedle vaccination also induced substantial levels of lung IgG and IgA antibody responses, and antibody-secreting plasma cells from spleen and bone marrow, as well as conferring effective control of lung viral loads, resulting in complete protection 14 months after vaccination. These strong and long-lasting immune responses were enabled in part by stabilization of the vaccine by formulation with trehalose during microneedle patch fabrication. Administration of the stabilized vaccine using microneedles was especially effective at enabling strong recall responses measured 4 days after lethal virus challenge, including increased HAI and antibody-secreting cells in the spleen and reduced viral titer and inflammatory response in the lung. The results in this study indicate that skin vaccination with VLP vaccine using a microneedle patch provides long-term protection against influenza in mice.

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7

Chiu, Chui Yu, Hsin Chuan Kuo, Yi Lin, Jeou Long Lee, Yung Kang Shen, and Sheng Jie Kang. "Optimal Design of Microneedles Inserts into Skin by Numerical Simulation." Key Engineering Materials 516 (June 2012): 624–28. http://dx.doi.org/10.4028/www.scientific.net/kem.516.624.

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The purpose of this research is to find the optimal design for biodegradable polymer microneedle patches. Based on the mechanical properties of different skin layers and the failure criterion of the material, this research designs a microneedle of four types and three sizes, then discusses the insertion force and the variation of stress during the process of PLA microneedle insertion into skin by numerical simulation. This research uses the dynamic finite element software ANSYS / LS-DYNA to simulate the processing for PLA microneedle inserts into skin. The master microneedle array was fabricated by the MEMS process. This research uses PDMS to fabricate the mould for microneedles. Finally, a biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated using a PDMS mould micro hot embossing method.

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8

Liu, Guiqin, Yan Deng, Yi Song, Yi Sui, Juan Cen, Ziyu Shao, Hu Li, and Tao Tang. "Transdermal Delivery of Adipocyte Phospholipase A2 siRNA using Microneedles to Treat Thyroid Associated Ophthalmopathy-Related Proptosis." Cell Transplantation 30 (January 1, 2021): 096368972110106. http://dx.doi.org/10.1177/09636897211010633.

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Thyroid associated ophthalmopathy (TAO) is an organ-specific autoimmune disease occurring in patients with thyroid disease. Patients with TAO-related proptosis is largely due to excessive orbital adipose tissue Adipocyte phospholipase A2 (AdPLA) is one of the most important regulatory factors in adipocyte lipolysis, which may be associated with TAO-related proptosis. Thus, silencing AdPLA by RNA interference may be beneficial for the treatment of TAO. In this study, we sought to evaluate the efficiency of two types of microneedles to deliver siRNAs for silencing AdPLA. Our results showed that AdPLA mRNA was up-regulated in the orbit adipose tissues from TAO patients. Silence of AdPLA by siRNA can reduce lipid accumulation in both human and mouse adipocyte cell lines. Moreover, silence effects of silicon microneedle array patch-based and injectable microneedle device-based siRNA administration were examined at the belly site of the mice, and injectable microneedle device showed higher knockdown efficiency than silicon microneedle array patch. This study sets the stage not only for future treatment of TAO-related proptosis using AdPLA siRNA, but also provides the foundation for targeted siRNA delivery by using microneedles.

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9

Al-Qallaf, Barrak, Diganta Bhusan Das, Daisuke Mori, and Zhanfeng Cui. "Modelling transdermal delivery of high molecular weight drugs from microneedle systems." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 365, no. 1861 (September 21, 2007): 2951–67. http://dx.doi.org/10.1098/rsta.2007.0003.

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In the past few years, a number of microneedle designs have been proposed for transdermal drug delivery of high molecular weight drugs. However, most of them do not increase the drug permeability in skin significantly. In other cases, designs developed based on certain criteria (e.g. strength of the microneedles) have failed to meet other criteria (e.g. drug permeability in skin, throughputs of the drugs, etc.). It is obvious therefore that in order to determine the ‘optimum’ design of these microneedles, the effect of different factors (e.g. length of the microneedle, surface area of the patch, etc.) along with various transport properties of drug transport behaviour using microneedles should be determined accurately. Appropriate mathematical models for drug transport from these systems into skin have the potential to resolve some of these issues. To address this, a parametric analysis for transdermal delivery of a high molecular weight drug from a microneedle is presented in this paper. The simulations have allowed us to identify the significance of various factors that influence the drug delivery while designing microneedle arrays. A scaling analysis is also done which shows the functional dependence of drug concentration on other variables of skin and microneedle arrays.

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10

Sadeq, Zainab A. "Microneedle Array Patches: Characterization and in -vitro Evaluation." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 30, no. 1 (June 15, 2021): 66–75. http://dx.doi.org/10.31351/vol30iss1pp66-75.

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Patch in transdermal drug delivery(TDDS) used to overcome the hypodermic drawback, but these patch also have absorption limitation for hydrophilic and macromolecule like peptide and DNA. So that micronized projection have the ability for skin penetration developed named as microneedle. Microneedle drug delivery system is a novel drug delivery to overcome the limitation of TDDS like skin barrier restriction for large molecule. Microneedle patch can penetrate through skin subcutaneous into epidermis, avoiding nerve fiber and blood vessel contact. There are many type of microneedle patch like solid, polymer, hallow, hydrogel forming microneedle and dissolving microneedle with different method of microfabrication

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11

Xue, Peng, David Chen Loong Yeo, Yon Jin Chuah, Hong Liang Tey, Yuejun Kang, and Chenjie Xu. "Drug-eluting microneedles for self-administered treatment of keloids." TECHNOLOGY 02, no. 02 (June 2014): 144–52. http://dx.doi.org/10.1142/s2339547814500137.

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Keloid is a long-term dermatological scarring disease characterized by disfiguring lesions resulting from overgrowth of dense fibrous tissue. Current therapeutics are ineffective, require clinical supervision and can be costly. This study investigated the use of microneedle technology in the self-management of keloid lesions. Specifically, a microneedle patch comprising of polyethylene glycol diacrylate (PEGDA) and encapsulating 5-fluorouracil (5-FU) has been developed for transdermal delivery. The microneedle patches showed requisite mechanical strength (hardness 45 ± 11 MPa, elastic modulus 0.66 ± 0.16 GPa) and were able to puncture porcine epidermis. The choice of PEGDA substrate enabled conformability to non-planar anatomical regions (e.g. elbow), with about 50% of the loaded 5-FU released during the first 12 hours. Thereafter, the microneedle efficacy was evaluated on in vitro keloid fibroblast culture models, where 5-FU loaded microneedles effectively abolished keloid fibroblast proliferation activity. In summary, we have developed a microneedle device with a good potential as an effective, economical and self-applied therapy for keloid scars.

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12

Gala, Rikhav, Rokon Zaman, Martin D’Souza, and Susu Zughaier. "Novel Whole-Cell Inactivated Neisseria Gonorrhoeae Microparticles as Vaccine Formulation in Microneedle-Based Transdermal Immunization." Vaccines 6, no. 3 (September 4, 2018): 60. http://dx.doi.org/10.3390/vaccines6030060.

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Neisseria gonorrhoeae is a strict human pathogen responsible for more than 100 million new sexually transmitted infections worldwide each year. Due to the global emergence of antibiotic resistance, the Center for Disease control (CDC) recently listed N. gonorrhoeae as an urgent threat to public health. No vaccine is available in spite of the huge disease burden and the possibility of untreatable gonorrhea. The aim of this study is to investigate the immunogenicity of a novel whole-cell-based inactivated gonococcal microparticle vaccine formulation loaded in dissolvable microneedles for transdermal administration. The nanotechnology-based vaccine formulation consists of inactivated whole-cell gonococci strain CDC-F62, spray dried and encapsulated into biodegradable cross-linked albumin matrix with sustained slow antigen release. The dry vaccine nanoparticles were then loaded in a dissolvable microneedle skin patch for transdermal delivery. The efficacy of the whole-cell microparticles vaccine formulation loaded in microneedles was assessed in vitro using dendritic cells and macrophages as well as in vivo mouse model. Antibody titers were measured using an enzyme immunosorbent assay (ELISA) and antigen-specific T lymphocytes were assessed in spleens and lymph nodes. Here we report that whole-cell-based gonococcal microparticle vaccine loaded in dissolvable microneedles for transdermal administration induced significant increase in antigen-specific IgG antibody titers and antigen-specific CD4 and CD8 T lymphocytes in mice compared to gonococcal antigens in solution or empty microneedles. Significant increase in antigen-specific IgG antibody levels was observed at the end of week 2 in groups that received the vaccine compared to the group receiving empty nanoparticles. The advantages of using formalin-fixed whole-cell gonococci that all immunogenic epitopes are covered and preserved from degradation. The spherical shaped micro and nanoparticles are biological mimics of gonococci, therefore present to the immune system as invaders but without the ability to suppress adaptive immunity. In conclusion, the transdermal delivery of microparticles vaccine via a microneedle patch was shown to be an effective system for vaccine delivery. The novel gonorrhea nanovaccine is cheap to produce in a stable dry powder and can be delivered in microneedle skin patch obviating the need for needle use or the cold chain.

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13

Samant, Pradnya P., Megan M. Niedzwiecki, Nicholas Raviele, Vilinh Tran, Juan Mena-Lapaix, Douglas I. Walker, Eric I. Felner, Dean P. Jones, Gary W. Miller, and Mark R. Prausnitz. "Sampling interstitial fluid from human skin using a microneedle patch." Science Translational Medicine 12, no. 571 (November 25, 2020): eaaw0285. http://dx.doi.org/10.1126/scitranslmed.aaw0285.

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Tissue interstitial fluid (ISF) surrounds cells and is an underutilized source of biomarkers that complements conventional sources such as blood and urine. However, ISF has received limited attention due largely to lack of simple collection methods. Here, we developed a minimally invasive, microneedle-based method to sample ISF from human skin that was well tolerated by participants. Using a microneedle patch to create an array of micropores in skin coupled with mild suction, we sampled ISF from 21 human participants and identified clinically relevant and sometimes distinct biomarkers in ISF when compared to companion plasma samples based on mass spectrometry analysis. Many biomarkers used in research and current clinical practice were common to ISF and plasma. Because ISF does not clot, these biomarkers could be continuously monitored in ISF similar to current continuous glucose monitors but without requiring an indwelling subcutaneous sensor. Biomarkers distinct to ISF included molecules associated with systemic and dermatological physiology, as well as exogenous compounds from environmental exposures. We also determined that pharmacokinetics of caffeine in healthy adults and pharmacodynamics of glucose in children and young adults with diabetes were similar in ISF and plasma. Overall, these studies provide a minimally invasive method to sample dermal ISF using microneedles and demonstrate human ISF as a source of biomarkers that may enable research and translation for future clinical applications.

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14

Quan, Fu-Shi, Yeu-Chun Kim, Aswani Vunnava, Dae-Goon Yoo, Jae-Min Song, Mark R. Prausnitz, Richard W. Compans, and Sang-Moo Kang. "Intradermal Vaccination with Influenza Virus-Like Particles by Using Microneedles Induces Protection Superior to That with Intramuscular Immunization." Journal of Virology 84, no. 15 (May 19, 2010): 7760–69. http://dx.doi.org/10.1128/jvi.01849-09.

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ABSTRACT Influenza virus-like particles (VLPs) are a promising cell culture-based vaccine, and the skin is considered an attractive immunization site. In this study, we examined the immunogenicity and protective efficacy of influenza VLPs (H1N1 A/PR/8/34) after skin vaccination using vaccine dried on solid microneedle arrays. Coating of microneedles with influenza VLPs using an unstabilized formulation was found to decrease hemagglutinin (HA) activity, whereas inclusion of trehalose disaccharide preserved the HA activity of influenza VLP vaccines after microneedles were coated. Microneedle vaccination of mice in the skin with a single dose of stabilized influenza VLPs induced 100% protection against challenge infection with a high lethal dose. In contrast, unstabilized influenza VLPs, as well as intramuscularly injected vaccines, provided inferior immunity and only partial protection (≤40%). The stabilized microneedle vaccination group showed IgG2a levels that were 1 order of magnitude higher than those of other groups and had the lowest lung viral titers after challenge. Also, levels of recall immune responses, including hemagglutination inhibition titers, neutralizing antibodies, and antibody-secreting plasma cells, were significantly higher after skin vaccination with stabilized formulations. Therefore, our results indicate that HA stabilization, combined with vaccination via the skin using a vaccine formulated as a solid microneedle patch, confers protection superior to that with intramuscular injection and enables potential dose-sparing effects which are reflected by pronounced increases in rapid recall immune responses against influenza virus.

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15

Edens, Chris, Marcus L. Collins, Jessica Ayers, Paul A. Rota, and Mark R. Prausnitz. "Measles vaccination using a microneedle patch." Vaccine 31, no. 34 (July 2013): 3403–9. http://dx.doi.org/10.1016/j.vaccine.2012.09.062.

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16

Benson, Philippa J. "A stem cell–integrated microneedle patch." Science 362, no. 6418 (November 29, 2018): 1014.6–1015. http://dx.doi.org/10.1126/science.362.6418.1014-f.

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17

Qu, Moyuan, Han-Jun Kim, Xingwu Zhou, Canran Wang, Xing Jiang, Jixiang Zhu, Yumeng Xue, et al. "Biodegradable microneedle patch for transdermal gene delivery." Nanoscale 12, no. 32 (2020): 16724–29. http://dx.doi.org/10.1039/d0nr02759f.

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18

Jiruedee, S., W. Luangweera, B. Sookyu, K. Patoomvasna, A. Pimpin, C. Rattanasumawong, T. Palaga, Siriporn Damrongsakkul, and W. Srituravanich. "Investigation of Optimal Silk Film Thickness in Silk Microneedle Fabrication." Applied Mechanics and Materials 752-753 (April 2015): 177–81. http://dx.doi.org/10.4028/www.scientific.net/amm.752-753.177.

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Injection is one of the most commonly used methods for delivering drugs or vaccines into human bodies. It is rapid, low-cost and compatible with almost any drugs. However, the major drawbacks of the injection by hypodermic needles are the pain associated with the injection and the disposal of used needles. Microneedles have then received wide attention since they can overcome such drawbacks, especially dissolving microneedles. Recently, silk fibroin has been used to fabricate dissolving silk microneedles for transdermal drug delivery at low temperature. In the fabrication process, the quality of the silk microneedles relies on the solidification of silk fibroin solution. This research aims to study the role of silk fibroin concentration (silk film thickness) in the formation of silk microneedles. In the experiment, silk microneedles were fabricated using various concentrations of silk fibroin solution from 3 to 7% while the volume of the silk fibroin solution was fixed. According to the experimental resuls, it was found that the concentrations of 4-5% were suitable for producing silk microneedles (silk film thickness of 470 μm) while the concentrations of 6-7% caused wrinkles on microneedle patch due to mismatch of upper and lower layers of microneedles. Furthermore, the concentration of 3% had a problem with the demolding step of microneedles since it caused mold damage due to strong adhesion force between microneedles and mold.

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19

Rouphael, Nadine G., and Mark J. Mulligan. "Microneedle patch for immunization of immunocompromised hosts." Oncotarget 8, no. 55 (October 25, 2017): 93311–12. http://dx.doi.org/10.18632/oncotarget.22072.

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20

Xu, Junhua, Ryan Danehy, Hongwei Cai, Zheng Ao, Meng Pu, Alexandra Nusawardhana, Dean Rowe-Magnus, and Feng Guo. "Microneedle Patch-Mediated Treatment of Bacterial Biofilms." ACS Applied Materials & Interfaces 11, no. 16 (April 2019): 14640–46. http://dx.doi.org/10.1021/acsami.9b02578.

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21

Xie, Xi, Conrado Pascual, Christopher Lieu, Seajin Oh, Ji Wang, Bende Zou, Julian Xie, et al. "Analgesic Microneedle Patch for Neuropathic Pain Therapy." ACS Nano 11, no. 1 (December 27, 2016): 395–406. http://dx.doi.org/10.1021/acsnano.6b06104.

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22

Zeng, Yi, Jinqiang Wang, Zejun Wang, Guojun Chen, Jicheng Yu, Sen Li, Qiwei Li, et al. "Colloidal crystal microneedle patch for glucose monitoring." Nano Today 35 (December 2020): 100984. http://dx.doi.org/10.1016/j.nantod.2020.100984.

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23

Prausnitz, Mark R., Yasmine Gomaa, and Wei Li. "Microneedle patch drug delivery in the gut." Nature Medicine 25, no. 10 (October 2019): 1471–72. http://dx.doi.org/10.1038/s41591-019-0606-0.

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24

Chi, Junjie, Lingyu Sun, Lijun Cai, Lu Fan, Changmin Shao, Luoran Shang, and Yuanjin Zhao. "Chinese herb microneedle patch for wound healing." Bioactive Materials 6, no. 10 (October 2021): 3507–14. http://dx.doi.org/10.1016/j.bioactmat.2021.03.023.

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25

Gomaa, Yasmine, Chandana Kolluru, Mikolaj Milewski, Dinah Lee, Jingtao Zhang, Robert Saklatvala, and Mark R. Prausnitz. "Development of a thermostable oxytocin microneedle patch." Journal of Controlled Release 337 (September 2021): 81–89. http://dx.doi.org/10.1016/j.jconrel.2021.07.011.

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26

Xue, Peng, Xuyang Zhang, Yon Jin Chuah, Yafeng Wu, and Yuejun Kang. "Flexible PEGDA-based microneedle patches with detachable PVP–CD arrowheads for transdermal drug delivery." RSC Advances 5, no. 92 (2015): 75204–9. http://dx.doi.org/10.1039/c5ra09329e.

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27

Wang, Yuanpeng, Haozheng Wang, X. X. Zhu, Ying Guan, and Yongjun Zhang. "Smart microneedle patches for rapid, and painless transdermal insulin delivery." Journal of Materials Chemistry B 8, no. 40 (2020): 9335–42. http://dx.doi.org/10.1039/d0tb01822h.

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28

Alkhiro, Adeeb R., and Mowafaq M. Ghareeb. "Formulation and Evaluation of Iornoxicam as Dissolving Microneedle Patch." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 29, no. 1 (June 25, 2020): 184–94. http://dx.doi.org/10.31351/vol29iss1pp184-194.

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The objective of the study was to develop microneedle (MN) patch, with suitable properties to ensure the delivery of a therapeutic level of lornoxicam (LXM) in a period suitable to replace parenteral administration in patients, especially those who fear needles. The used polymers were cold water-soluble polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) of low molecular weight with PEG 400 as plasticizer and Tween 80 (to enhance the release) using micro molding technique. Patches were studied for needle morphology, drug content, axial fracture force measurement and drug release while the optimized formulas were further subjected to pH measurement, folding endurance, ex vivo permeation study, histopathology study, stability study and compatibility study. The patch with 11:1 ratio of PVA to PVP, 30% solid content, 5% PEG 400 and 3% Tween 80 resulted in axial needle fracture force value of (1.35 N) which is suitable for skin penetration. The release was fast with almost 100% of drug released in 60 minutes. The permeation was enhanced significantly with a steady state flux of about 3.1 times that of the solution. The lag time of MN is shorter in comparison with ordinary patch. Histopathology studies demonstrated the safety of the formulation, both stability studies and compatibility studies showed the suitability of the formulation. The results indicated that LXM microneedle patch could enhance drug permeation while achieving fast and painless administration. Keywords: Microneedle patch, Polyvinyl alcohol, Polyvinylpyrrolidone, Fracture force, Lornoxicam.

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Hiraishi, Yasuhiro, Subhadra Nandakumar, Seong-O. Choi, Jeong Woo Lee, Yeu-Chun Kim, James E. Posey, Suraj B. Sable, and Mark R. Prausnitz. "Bacillus Calmette-Guérin vaccination using a microneedle patch." Vaccine 29, no. 14 (March 2011): 2626–36. http://dx.doi.org/10.1016/j.vaccine.2011.01.042.

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30

Li, Yan, Fanmao Liu, Chen Su, Bingbo Yu, Di Liu, Hui-Jiuan Chen, Di-an Lin, et al. "Biodegradable Therapeutic Microneedle Patch for Rapid Antihypertensive Treatment." ACS Applied Materials & Interfaces 11, no. 34 (August 6, 2019): 30575–84. http://dx.doi.org/10.1021/acsami.9b09697.

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31

Zhang, Yuqi, Peijian Feng, Jicheng Yu, Jia Yang, Jiacheng Zhao, Jinqiang Wang, Qundong Shen, and Zhen Gu. "ROS-Responsive Microneedle Patch for Acne Vulgaris Treatment." Advanced Therapeutics 1, no. 3 (May 22, 2018): 1800035. http://dx.doi.org/10.1002/adtp.201800035.

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32

Tas, Cetin, Saffar Mansoor, Haripriya Kalluri, Vladimir G. Zarnitsyn, Seong-O. Choi, Ajay K. Banga, and Mark R. Prausnitz. "Delivery of salmon calcitonin using a microneedle patch." International Journal of Pharmaceutics 423, no. 2 (February 2012): 257–63. http://dx.doi.org/10.1016/j.ijpharm.2011.11.046.

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33

Sun, Lingyu, Lu Fan, Feika Bian, Guopu Chen, Yuetong Wang, and Yuanjin Zhao. "MXene-Integrated Microneedle Patches with Innate Molecule Encapsulation for Wound Healing." Research 2021 (June 30, 2021): 1–9. http://dx.doi.org/10.34133/2021/9838490.

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Wound healing is a complex physiological process that involves coordinated phases such as inflammation and neovascularization. Attempts to promote the healing process tend to construct an effective delivery system based on different drugs and materials. In this paper, we propose novel MXene-integrated microneedle patches with adenosine encapsulation for wound healing. Owing to the dynamic covalent bonding capacity of boronate molecules with adenosine, 3-(acrylamido)phenylboronic acid- (PBA-) integrated polyethylene glycol diacrylate (PEGDA) hydrogel is utilized as the host material of microneedle patches. Benefitting from photothermal conversion capacity of MXene, the release of loaded adenosine could be accelerated under NIR irradiation for maintaining the activation signal around injury site. In vitro cell experiments proved the effect of MXene-integrated microneedle patches with adenosine encapsulation in enhancing angiogenesis. When applied for treating animal models, it is demonstrated that the microneedle patches efficiently promote angiogenesis, which is conductive to wound healing. These features make the proposed microneedle patch potential for finding applications in wound healing and other biomedical fields.

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Xu, Bin, Guohua Jiang, Weijiang Yu, Depeng Liu, Yang Zhang, Junyi Zhou, Shiqing Sun, and Yongkun Liu. "H2O2-Responsive mesoporous silica nanoparticles integrated with microneedle patches for the glucose-monitored transdermal delivery of insulin." J. Mater. Chem. B 5, no. 41 (2017): 8200–8208. http://dx.doi.org/10.1039/c7tb02082a.

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35

Arya, Jaya M., Kristopher Dewitt, Maya Scott-Garrard, Yu-Wei Chiang, and Mark R. Prausnitz. "Rabies vaccination in dogs using a dissolving microneedle patch." Journal of Controlled Release 239 (October 2016): 19–26. http://dx.doi.org/10.1016/j.jconrel.2016.08.012.

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36

Tang, Junnan, Jinqiang Wang, Ke Huang, Yanqi Ye, Teng Su, Li Qiao, Michael Taylor Hensley, et al. "Cardiac cell–integrated microneedle patch for treating myocardial infarction." Science Advances 4, no. 11 (November 2018): eaat9365. http://dx.doi.org/10.1126/sciadv.aat9365.

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We engineered a microneedle patch integrated with cardiac stromal cells (MN-CSCs) for therapeutic heart regeneration after acute myocardial infarction (MI). To perform cell-based heart regeneration, cells are currently delivered to the heart via direct muscle injection, intravascular infusion, or transplantation of epicardial patches. The first two approaches suffer from poor cell retention, while epicardial patches integrate slowly with host myocardium. Here, we used polymeric MNs to create “channels” between host myocardium and therapeutic CSCs. These channels allow regenerative factors secreted by CSCs to be released into the injured myocardium to promote heart repair. In the rat MI model study, the application of the MN-CSC patch effectively augmented cardiac functions and enhanced angiomyogenesis. In the porcine MI model study, MN-CSC patch application was nontoxic and resulted in cardiac function protection. The MN system represents an innovative approach delivering therapeutic cells for heart regeneration.

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Zhang, Yuqi, Jicheng Yu, Di Wen, Guojun Chen, and Zhen Gu. "The potential of a microneedle patch for reducing obesity." Expert Opinion on Drug Delivery 15, no. 5 (March 14, 2018): 431–33. http://dx.doi.org/10.1080/17425247.2018.1449831.

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38

Zan, Ping, Aung Than, Phan Khanh Duong, Juha Song, Chuanhui Xu, and Peng Chen. "Antimicrobial Microneedle Patch for Treating Deep Cutaneous Fungal Infection." Advanced Therapeutics 2, no. 10 (August 7, 2019): 1900064. http://dx.doi.org/10.1002/adtp.201900064.

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39

Mistilis, Matthew J., Andreas S. Bommarius, and Mark R. Prausnitz. "Development of a Thermostable Microneedle Patch for Influenza Vaccination." Journal of Pharmaceutical Sciences 104, no. 2 (February 2015): 740–49. http://dx.doi.org/10.1002/jps.24283.

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40

Invernale, Michael A., Benjamin C. Tang, Royce L. York, Long Le, David Yupeng Hou, and Daniel G. Anderson. "Microneedle Electrodes Toward an Amperometric Glucose-Sensing Smart Patch." Advanced Healthcare Materials 3, no. 3 (August 29, 2013): 338–42. http://dx.doi.org/10.1002/adhm.201300142.

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41

Chang, Kai-Ti, Yung-Kang Shen, Fang-Yu Fan, Yi Lin, and Sheng-Chieh Kang. "Optimal design and fabrication of a microneedle arrays patch." Journal of Manufacturing Processes 54 (June 2020): 274–85. http://dx.doi.org/10.1016/j.jmapro.2020.02.024.

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42

Kolluru, Chandana, Yasmine Gomaa, and Mark R. Prausnitz. "Development of a thermostable microneedle patch for polio vaccination." Drug Delivery and Translational Research 9, no. 1 (December 12, 2018): 192–203. http://dx.doi.org/10.1007/s13346-018-00608-9.

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43

Kathuria, Himanshu, Hairui Li, Jing Pan, Seng Han Lim, Jaspreet Singh Kochhar, Chunyong Wu, and Lifeng Kang. "Large Size Microneedle Patch to Deliver Lidocaine through Skin." Pharmaceutical Research 33, no. 11 (July 11, 2016): 2653–67. http://dx.doi.org/10.1007/s11095-016-1991-4.

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44

Lopez-Ramirez, Miguel Angel, Daniel Kupor, Leonardo Marchiori, Fernando Soto, Ricardo Rueda, Maria Reynoso, Lakshmi Rekha Narra, Krishnan Chakravarthy, and Joseph Wang. "Combinatorial microneedle patch with tunable release kinetics and dual fast-deep/sustained release capabilities." Journal of Materials Chemistry B 9, no. 9 (2021): 2189–99. http://dx.doi.org/10.1039/d1tb00141h.

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This manuscript introduces a combinatorial microneedle patch with variable dissolution rate and tunable release in a single application; it delivers payloads in minutes while simultaneously deliver dosages from weeks to months with constant release.

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45

Song, Ji Eun, Seung-Hyun Jun, Sun-Gyoo Park, and Nae-Gyu Kang. "A Semi-Dissolving Microneedle Patch Incorporating TEMPO-Oxidized Bacterial Cellulose Nanofibers for Enhanced Transdermal Delivery." Polymers 12, no. 9 (August 20, 2020): 1873. http://dx.doi.org/10.3390/polym12091873.

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Although dissolving microneedles have garnered considerable attention as transdermal delivery tools, insufficient drug loading remains a challenge owing to their small dimension. Herein, we report a one-step process of synthesizing semi-dissolving microneedle (SDMN) patches that enable effective transdermal drug delivery without loading drugs themselves by introducing TEMPO-oxidized bacterial cellulose nanofibers (TOBCNs), which are well dispersed, while retaining their unique properties in the aqueous phase. The SDMN patch fabricated by the micro-molding of a TOBCN/hydrophilic biopolymer mixture had a two-layer structure comprising a water-soluble needle layer and a TOBCN-containing insoluble backing layer. Moreover, the SDMN patch, which had a hole in the backing layer where TOBCNs are distributed uniformly, could offer novel advantages for the delivery of large quantities of active ingredients. In vitro permeation analysis confirmed that TOBCNs with high water absorption capacity could serve as drug reservoirs. Upon SDMN insertion and the application of drug aqueous solution through the drug inlet hole, the TOBCNs rapidly absorbed the solution and supplied it to the needle layer. Simultaneously, the needle layer dissolved in body fluids and the drug solution to form micro-channels, which enabled the delivery of larger quantities of drugs to the skin compared to that enabled by solution application alone.

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46

He, Xiaoxiang, Jingyao Sun, Jian Zhuang, Hong Xu, Ying Liu, and Daming Wu. "Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects." Dose-Response 17, no. 4 (October 1, 2019): 155932581987858. http://dx.doi.org/10.1177/1559325819878585.

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Microneedle (MN) delivery system has been greatly developed to deliver drugs into the skin painlessly, noninvasively, and safety. In the past several decades, various types of MNs have been developed by the newer producing techniques. Briefly, as for the morphologically, MNs can be classified into solid, coated, dissolved, and hollow MN, based on the transdermal drug delivery methods of “poke and patch,” “coat and poke,” “poke and release,” and “poke and flow,” respectively. Microneedles also have other characteristics based on the materials and structures. In addition, various manufacturing techniques have been well-developed based on the materials. In this review, the materials, structures, morphologies, and fabricating methods of MNs are summarized. A separate part of the review is used to illustrate the application of MNs to deliver vaccine, insulin, lidocaine, aspirin, and other drugs. Finally, the review ends up with a perspective on the challenges in research and development of MNs, envisioning the future development of MNs as the next generation of drug delivery system.

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Han, Sang-Kuk, Seung-Jun Lee, and Hun-Yong Ha. "Skin Moisturizing Effects of a Microneedle Patch Containing Hyaluronic Acid and Lonicerae flos." Processes 9, no. 2 (February 9, 2021): 321. http://dx.doi.org/10.3390/pr9020321.

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The utilization of cosmetic raw materials for medicinal purposes in a microneedle patch containing hyaluronic acid (HA) and Lonicerae flos ethanol extract (LEE) has increased based on their eco-friendly characteristics. The moisturizing effects of this microneedle patch were assessed on the forearms of 20 female participants, and our results showed an increase between 29.60% and 88.54% in skin moisture content at the same time points relative to the untreated group. Apart from confirming the safety of HA and Lonicerae flos, our findings may also promote the use of HA and medicinal herbs in relevant industries, indicating their potential as raw ingredients for the development of cosmetic products and topical dermatological drugs. The results suggested that HA, Lonicerae flos, and other combinations of chemical and natural products based on traditional oriental medicine could beneficially affect skin health.

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48

Kolluru, Chandana, Rohit Gupta, Qisheng Jiang, Mikayla Williams, Hamed Gholami Derami, Sisi Cao, Richard K. Noel, Srikanth Singamaneni, and Mark R. Prausnitz. "Plasmonic Paper Microneedle Patch for On-Patch Detection of Molecules in Dermal Interstitial Fluid." ACS Sensors 4, no. 6 (May 9, 2019): 1569–76. http://dx.doi.org/10.1021/acssensors.9b00258.

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49

Li, Xinfang, Qinan Xu, Jing Wang, Peng Zhang, Youxiang Wang, and Jian Ji. "A gene-coated microneedle patch based on industrialized ultrasonic spraying technology with a polycation vector to improve antitumor efficacy." Journal of Materials Chemistry B 9, no. 27 (2021): 5528–36. http://dx.doi.org/10.1039/d1tb00512j.

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Two-step ultrasonic spraying can make an interpenetrating structure composed of p53 DNA and PEI on coated microneedle patch (P@D@MNP); P@D@MNP shows good anti-tumor efficiency, and it has potential to be a drug/gene transdermal delivery platform.

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50

Chen, Bo Zhi, Li Qin Zhang, Yi Yun Xia, Xiao Peng Zhang, and Xin Dong Guo. "A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control." Science Advances 6, no. 28 (July 2020): eaba7260. http://dx.doi.org/10.1126/sciadv.aba7260.

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Multiple daily insulin injections have been a common regimen worldwide for the management of diabetes mellitus but involved potential safety and compliance problems. In this context, a single integrated microneedle patch (IMP) with multiple release kinetics is demonstrated to provide better physiologic insulin coverage for postprandial glycemic excursion in a convenient and pain-free manner. The combination of rapid separating technique and multiple individual microneedle arrays provides the combined ability to efficiently deliver insulin into the skin within seconds and to independently control insulin release kinetics. In addition, the diabetic rats with a traditional breakfast-lunch-dinner lifestyle exhibit obvious intraday glucose fluctuations, while the hypoglycemic experiments indicate that the IMP is capable of simultaneous bolus and sustained insulin delivery to closely match the glucose rise that occurs in response to meals and efficiently minimize excessive fluctuations, suggesting the potential of this new transdermal insulin delivery system as substitutes for multiple daily injections.

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