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Journal articles on the topic 'Microneedle technology'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Pavan, Khomane Reshma Mirajkar* Ashwini Madgulkar Mrunmayee Velapure. "Microneedle Technology: Advancements, Applications, and Future Different Directions." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3412–22. https://doi.org/10.5281/zenodo.15473291.

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Microneedle Technology: Progress, Uses, and Prospects Micro needles, micro meter-sized instruments for minimally invasive transdermal delivery, provide an auspicious option against conventional injections. This review canvasses the new developments in micro needle technology with features of pain-free application, better drug bioavailability, and minimizing bio hazardous waste. We consider here the several different types of microneedles, namely, solid, coated, dissolving, and hydrogel, specifically designed for selected drug delivery strategies and therapeutic indications. The manufacturing p

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2

Kadam, Snehal Kasu Daniya Momin Ishrat Shaikh Shama* Khan Sharina Poonam Patil. "Microneedle Technology: A Revolutionary Approach to Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 106–39. https://doi.org/10.5281/zenodo.15119727.

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Microneedle system is a type of new generation transdermal drug delivery systems (TDDS) which eliminate the main disadvantages of drug administration through the skin. This paper undertakes a review of the development of the microneedle technology which has been developed as a non-invasive procedure in drug delivery across the skin because it reduces the effectiveness of the first barrier to penetration, the stratum corneum. One improved characteristic of microneedles is that they span several wells yet their size makes them permeable to water and small molecule drugs therefore providing more

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3

Rizwan, Boyeekati Mohammad, Nawaz Mahammed, Shaik Farheen Taj, V. Sivasai Bharath Kumar, and B. Yamuna. "A Review on Puncturing Potential: Microneedles' Present Landscape And Prospective Horizons." Jordan Journal of Pharmaceutical Sciences 18, no. 2 (2025): 566–85. https://doi.org/10.35516/jjps.v18i2.2763.

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Microneedle technology has emerged as a promising approach for drug delivery, vaccination, diagnostics, and cosmetic treatments. This review provides an overview of microneedle technology, covering the various types of microneedles, fabrication techniques, applications, advantages, challenges, safety considerations, clinical translation, and future perspectives. Solid, hollow, dissolving, coated, and hydrogel-forming microneedles are discussed, along with their structures, materials, and fabrication methods. Applications in drug delivery, vaccination, diagnostics, and cosmetic treatments are e

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Alfisha Khan, Pragati Mishra, Deepika Gupta, and Poonam Kumari. "Advances in Transdermal Drug Delivery Systems: From Patches to Microneedles." Journal of Drug Discovery and Health Sciences 1, no. 02 (2024): 105–12. https://doi.org/10.21590/jddhs.01.02.06.

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Microneedle technology has emerged as a groundbreaking innovation in transdermal drug delivery systems (TDDS), offering a less invasive method to administer drugs through the skin. These micron-sized needles penetrate the stratum corneum, the outermost layer of the skin, to deliver therapeutic agents ranging from vaccines to insulin and biologics. The four main types of microneedles—solid, coated, dissolvable, and hollow—each serve unique purposes in optimizing drug delivery efficiency and patient comfort.Solid microneedles are typically made of metals like stainless steel and titanium, offeri

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Nguyen, Hiep X., and Chien N. Nguyen. "Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals." Pharmaceutics 15, no. 1 (2023): 277. http://dx.doi.org/10.3390/pharmaceutics15010277.

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Transdermal delivery provides numerous benefits over conventional routes of administration. However, this strategy is generally limited to a few molecules with specific physicochemical properties (low molecular weight, high potency, and moderate lipophilicity) due to the barrier function of the stratum corneum layer. Researchers have developed several physical enhancement techniques to expand the applications of the transdermal field; among these, microneedle technology has recently emerged as a promising platform to deliver therapeutic agents of any size into and across the skin. Typically, h

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Xu, Jie, Danfeng Xu, Xuan Xuan, and Huacheng He. "Advances of Microneedles in Biomedical Applications." Molecules 26, no. 19 (2021): 5912. http://dx.doi.org/10.3390/molecules26195912.

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A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical ther

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7

Kang, Seongsu, Ji Eun Song, Seung-Hyun Jun, Sun-Gyoo Park, and Nae-Gyu Kang. "Sugar-Triggered Burst Drug Releasing Poly-Lactic Acid (PLA) Microneedles and Its Fabrication Based on Solvent-Casting Approach." Pharmaceutics 14, no. 9 (2022): 1758. http://dx.doi.org/10.3390/pharmaceutics14091758.

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Microneedles have emerged as a novel transdermal delivery tool that enables the delivery of various products such as drugs, vaccines, or cosmetic ingredients. Although the demand for solid microneedles composed of biocompatible polymer is increasing, the manufacture of microneedles using poly-lactic acid (PLA) with rapid drug-releasing is yet to be established and the process is still in its infancy. Here, we propose a novel strategy for the fabrication of PLA solid microneedles which enable a drug to be burst-released based on a solvent-casting process. This approach offers extreme simplicity

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8

Choo, Sangmin, SungGiu Jin, and JaeHwan Jung. "Fabricating High-Resolution and High-Dimensional Microneedle Mold through the Resolution Improvement of Stereolithography 3D Printing." Pharmaceutics 14, no. 4 (2022): 766. http://dx.doi.org/10.3390/pharmaceutics14040766.

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Microneedles are transdermal drug delivery tools that can be fabricated simply, economically, and rapidly using SLA 3D printing. However, SLA 3D printing has a limitation in that the resolution is slightly lowered when the microneedle is precisely printed. To solve this issue, we optimized the SLA 3D printing conditions such as printing angle, needle height, aspect ratio, and spacing between the microneedles for high-resolution microneedle fabrication. The sharpest microneedle tip was obtained when the printing angle was adjusted to 60° in both the x and y axes. The aspect ratio and the spacin

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Amato, Camilla, Daria Cermola, Raffaele Vecchione, and Carla Langella. "Design for optimisation of drug administration." Journal of Health Design 9, no. 1 (2024): 605–10. http://dx.doi.org/10.21853/jhd.2024.224.

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In the last few years, a new technology based on microneedles has been used for the delivery of drugs and vaccines. Microneedle patches ensure rapid, easy, and hygienic administration of drugs. This project was conceived to ensure the comfortable and safe transport as well as the sterile application of microneedles by users. Microneedles are particularly useful for diseases requiring daily medical care via distributed therapeutic treatments throughout the day. Microneedle Reminder is a wearable device for the wrist, containing nine ready-to-use patches.

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10

Gaurav P. Aswar, Pooja R. Hatwar, Ravindra L. Bakal, Vaishnavi S. Kalamb, and Ishar K. Thak. "Microneedles: An efficient technique to enhance Transdermal Drug Delivery System." GSC Biological and Pharmaceutical Sciences 29, no. 3 (2024): 256–66. https://doi.org/10.30574/gscbps.2024.29.3.0480.

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Microneedle technology has emerged as a promising tool for enhancing transdermal drug delivery. This technology involves the use of micron-sized needles to create microchannels in the skin, allowing for the delivery of drugs, vaccines, and other therapeutic agents. The skin's outermost layer, the stratum corneum, is the primary barrier to drug penetration, and microneedles have been shown to effectively bypass this barrier. Various types of microneedles have been developed, including solid, coated, dissolving, and hollow microneedles, each with its own advantages and disadvantages. Microneedle

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Gaurav, P. Aswar, R. Hatwar Pooja, L. Bakal Ravindra, S. Kalamb Vaishnavi, and K. Thak Ishar. "Microneedles: An efficient technique to enhance Transdermal Drug Delivery System." GSC Biological and Pharmaceutical Sciences 29, no. 3 (2024): 256–66. https://doi.org/10.5281/zenodo.14915541.

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Microneedle technology has emerged as a promising tool for enhancing transdermal drug delivery. This technology involves the use of micron-sized needles to create microchannels in the skin, allowing for the delivery of drugs, vaccines, and other therapeutic agents. The skin's outermost layer, the stratum corneum, is the primary barrier to drug penetration, and microneedles have been shown to effectively bypass this barrier. Various types of microneedles have been developed, including solid, coated, dissolving, and hollow microneedles, each with its own advantages and disadvantages. Microneedle

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12

Yu, Ketian, Yukun Ma, Yiming Wei, et al. "Individually Modified Microneedle Array for Minimal Invasive Multi-Electrolyte Monitoring." Biosensors 15, no. 5 (2025): 310. https://doi.org/10.3390/bios15050310.

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Electrolytes play crucial roles in regulating nerve and muscle functions. Currently, microneedle technology enables real-time electrolyte monitoring through minimally invasive methods. However, due to the small size of microneedles, performing multi-layer modifications on individual microneedles and ensuring the integrity of these layers pose significant challenges. Additionally, the puncture efficiency of the electrodes will be affected by the structure of microneedle array integration. To address these issues, we primarily focus on developing a multi-parameter ion monitoring system based on

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13

Chaiprateep, Em-on, Soma Sengupta, and Cornelia M. Keck. "Microneedle-Assisted Delivery of Curcumin: Evaluating the Effects of Needle Length and Formulation." Micromachines 16, no. 2 (2025): 155. https://doi.org/10.3390/mi16020155.

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Dermal drug delivery presents a significant challenge for poorly soluble active compounds like curcumin, which often struggle to penetrate the skin barrier effectively. In this study, the dermal penetration efficacy of curcumin nanocrystals and bulk suspensions when applied to skin using microneedles of varying lengths—0.25 mm, 0.5 mm, and 1.0 mm—was investigated in an ex vivo porcine ear model. The findings revealed that all formulations, in conjunction with microneedle application, facilitated transepidermal penetration; however, the combination of microneedles and curcumin nanocrystals demo

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14

Ju, Sanghwi, Seung-hyun Im, Kyungsun Seo, et al. "Parametric Rule-Based Intelligent System (PRISM) for Design and Analysis of High-Strength Separable Microneedles." Micromachines 16, no. 7 (2025): 726. https://doi.org/10.3390/mi16070726.

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Transdermal microneedle systems have received great attention due to their minimally invasive way of delivering biomolecules through the skin with reduced pain. However, designing high-strength separable microneedles, which enable easy skin penetration and easy patch detachment, is challenging. Here, we present a Parametric Rule-based Intelligent System (PRISM), which generates the design of and analyzes high-strength separable microneedles. The PRISM platform integrates parametric 3D modeling, geometry-based structural analysis, and high-resolution micro-3D printing for the creation of high-s

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15

Sianipar, Christoforus, Erline Yosida, and Sari Wangi. "Optimization of geometry and building orientation on the accuracy of dissolving microneedle masters using stereolithography." Journal of Applied Engineering Science 23, no. 2 (2025): 291–302. https://doi.org/10.5937/jaes0-55337.

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Microneedles have gained prominence as a minimally invasive transdermal drug delivery technology, offering significant advantages such as reduced pain, targeted drug delivery, and decreased medical waste. This study focuses on the optimization of dissolvable self-locking microneedles fabricated using stereolithography (SLA), with an emphasis on dimensional accuracy. Three microneedle geometries-perpendicular, concave, and convex-were investigated across three building orientations (0°, 45°, and 60°). Microneedle masters were printed using SLA and subsequently used as molds to fabricate PDMS mi

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16

Rahman, Aqila Che Ab, and Sooman Lim. "Development of Cone-Type Stretchable Transdermal Drug Delivery Microneedle Patch Based on 3D Printing Technology." Journal of Flexible and Printed Electronics 3, no. 1 (2024): 85–94. http://dx.doi.org/10.56767/jfpe.2024.3.1.85.

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This study explored the potential of microneedle technology in transdermal drug delivery application based on a one-step fabrication process using digital light-processing (DLP) printing. To fabricate high-resolution microneedles, DLP printing parameters which include the printing angle were optimized from 0°, 40° and 60° in x-axes. The microneedle substrate was optimized to maintain high stretchability and durability to adapt to dynamic deformations resulting from human movement. The fabricated microneedle demonstrated good ability to effectively penetrate the artificial skin, releasing Rhoda

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17

Wang, Wenkai, Yanhong Liang, Xiaoxiao Yan, Gang Tang, Fang Xu, and Zhibiao Li. "Based on Finite Element Simulation: Optimization of Microneedle Structure and Mechanical Performance Analysis." Journal of Physics: Conference Series 2890, no. 1 (2024): 012059. http://dx.doi.org/10.1088/1742-6596/2890/1/012059.

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Abstract Microneedles, as an innovative drug delivery technology, demonstrate great potential for application due to their superior performance in transdermal drug delivery. Compared with traditional injection needles, microneedles can reduce pain and the risk of infection after insertion into the skin, and have the potential to organically combine with other external technologies to further enhance the effectiveness of drug delivery and therapeutic effect. However, to achieve efficient drug delivery, the design and optimization of microneedles must comprehensively consider their mechanical pr

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18

Luo, Rui, Huihui Xu, Qiaoni Lin, et al. "Emerging Trends in Dissolving-Microneedle Technology for Antimicrobial Skin-Infection Therapies." Pharmaceutics 16, no. 9 (2024): 1188. http://dx.doi.org/10.3390/pharmaceutics16091188.

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Skin and soft-tissue infections require significant consideration because of their prolonged treatment duration and propensity to rapidly progress, resulting in severe complications. The primary challenge in their treatment stems from the involvement of drug-resistant microorganisms that can form impermeable biofilms, as well as the possibility of infection extending deep into tissues, thereby complicating drug delivery. Dissolving microneedle patches are an innovative transdermal drug-delivery system that effectively enhances drug penetration through the stratum corneum barrier, thereby incre

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Arora, Monica, and Tanjima Tarique Laskar. "Microneedles: Recent advances and development in the field of transdermal drug delivery technology." Journal of Drug Delivery and Therapeutics 13, no. 3 (2023): 155–63. http://dx.doi.org/10.22270/jddt.v13i3.5967.

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Microneedles have emerged as a novel therapeutic modality in transdermal drug delivery system. The concept of microneedle has caught attention of the investigators owing to its immense utilities and unique promising features of painless drug delivery by crossing the impervious barrier layer of stratum corneum of skin efficiently in a non-invasive manner. It provides excellent therapeutic potency and bioavailability of drugs compared to most other conventional drug delivery routes. Microneedles have supremacy on avoidance of pre-systemic first pass metabolism of administered drugs, better patie

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Czarczynska-Goslinska, Beata, Tomasz Goslinski, Agata Roszak, et al. "Microneedle System Coated with Hydrogels Containing Protoporphyrin IX for Potential Application in Pharmaceutical Technology." Methods and Protocols 7, no. 5 (2024): 73. http://dx.doi.org/10.3390/mps7050073.

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The article aims to outline the potential of treating malignant skin cancer with microneedles covered with polymer layers containing a photosensitizer—protoporphyrin IX disodium salt (PPIX). The usefulness of stereolithography (SLA), which is a form of 3D-printing technology, for the preparation of a microneedle system with protoporphyrin IX was demonstrated. The SLA method allowed for pyramid-shaped microneedles to be printed that were covered with three different 0.1% PPIX hydrogels based on sodium alginate, xanthan, and poloxamer. Rheological tests and microscopic analysis of the hydrogels

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Bhadouria, Namrata, Shikha Yadav, Sarad Pawar Naik Bukke, and Bayapa Reddy Narapureddy. "Advancements in vaccine delivery: harnessing 3D printing for microneedle patch technology." Annals of Medicine & Surgery 87, no. 4 (2025): 2059–67. https://doi.org/10.1097/ms9.0000000000003060.

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The development of 3D-printed microneedle (MN) technology is a significant step in vaccine delivery, providing a painless, effective, and adaptable substitute for conventional injection-based techniques. Direct transdermal vaccination distribution without the need for needles is made possible by microneedle patches, which employ a variety of tiny needles that dissolve when they penetrate the skin. By using 3D printing to precisely customise microneedles’ size, shape, and density to meet particular vaccine requirements, administration control can be improved and vaccine efficiency may even be i

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Nagrik, Shivshankar M., Vaishnavi S. Akhare, Manisha W. Bhade, et al. "Advances in Transdermal Drug Delivery: The Development of Microneedle Technology for Improved Therapeutic Outcomes." Journal for Research in Applied Sciences and Biotechnology 3, no. 5 (2024): 200–210. http://dx.doi.org/10.55544/jrasb.3.5.21.

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Transdermal Drug Delivery Systems (TDDS) represent a significant advancement in therapeutic administration by allowing drugs to bypass the gastrointestinal system and first-pass hepatic metabolism, enhancing patient compliance, and enabling sustained drug release. However, traditional TDDS face limitations, including resistance from the skin's natural barrier and limited efficacy in delivering large or hydrophilic molecules. Microneedle (MN) technology offers a breakthrough solution, using minimally invasive micron-sized needles to bypass the stratum corneum, facilitating efficient drug delive

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Vedika N. Dafe, Pooja R. Hatwar, Ravindra L. Bakal, Jitendra A. Kubde, and Kajal S. Jumde. "Transdermal insulin delivery via microneedle technology, patches, and pumps offers a promising alternative to traditional subcutaneous injections for diabetes management." GSC Biological and Pharmaceutical Sciences 29, no. 1 (2024): 233–42. http://dx.doi.org/10.30574/gscbps.2024.29.1.0372.

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Transdermal insulin delivery offers a promising alternative to traditional subcutaneous injections, providing a pain-free and self-administrable treatment option for diabetes management. Microneedle technology has emerged as a viable approach, leveraging tiny needle-like projections to bypass the stratum corneum and deliver insulin systemically. Various materials, including metal, silicon, ceramic, polymer, and silica glass, are being explored for microneedle fabrication. This review discusses the anatomy of skin, pathways of drug absorption, and advantages of transdermal drug delivery systems

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Vedika, N. Dafe, R. Hatwar Pooja, L. Bakal Ravindra, A. Kubde Jitendra, and S. Jumde Kajal. "Transdermal insulin delivery via microneedle technology, patches, and pumps offers a promising alternative to traditional subcutaneous injections for diabetes management." GSC Biological and Pharmaceutical Sciences 29, no. 1 (2024): 233–42. https://doi.org/10.5281/zenodo.14717188.

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Transdermal insulin delivery offers a promising alternative to traditional subcutaneous injections, providing a pain-free and self-administrable treatment option for diabetes management. Microneedle technology has emerged as a viable approach, leveraging tiny needle-like projections to bypass the stratum corneum and deliver insulin systemically. Various materials, including metal, silicon, ceramic, polymer, and silica glass, are being explored for microneedle fabrication. This review discusses the anatomy of skin, pathways of drug absorption, and advantages of transdermal drug delivery systems

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Faraji Rad, Zahra, Philip D. Prewett, and Graham J. Davies. "An overview of microneedle applications, materials, and fabrication methods." Beilstein Journal of Nanotechnology 12 (September 13, 2021): 1034–46. http://dx.doi.org/10.3762/bjnano.12.77.

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Microneedle-based microdevices promise to expand the scope for delivery of vaccines and therapeutic agents through the skin and withdrawing biofluids for point-of-care diagnostics – so-called theranostics. Unskilled and painless applications of microneedle patches for blood collection or drug delivery are two of the advantages of microneedle arrays over hypodermic needles. Developing the necessary microneedle fabrication processes has the potential to dramatically impact the health care delivery system by changing the landscape of fluid sampling and subcutaneous drug delivery. Microneedle desi

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Narayan, Roger. "(Invited) integration of Microneedles and Electrochemical Sensors for Medical Applications." ECS Meeting Abstracts MA2023-01, no. 34 (2023): 1942. http://dx.doi.org/10.1149/ma2023-01341942mtgabs.

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Microneedles are small-scale devices that may be used for access to interstitial fluid and/or capillary blood for transdermal monitoring of chemicals [1]. In this presentation, the integration of several types of electrochemical sensors with hollow microneedles will be considered. For example, carbon fiber electrodes have been integrated with digital micromirror device-produced microneedles; ascorbic acid and hydrogen peroxide were detected with these devices [2]. Carbon paste electrodes have also been integrated with digital micromirror device-produced microneedles; electrodes made from rhodi

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Xue, Peng, David Chen Loong Yeo, Yon Jin Chuah, Hong Liang Tey, Yuejun Kang, and Chenjie Xu. "Drug-eluting microneedles for self-administered treatment of keloids." TECHNOLOGY 02, no. 02 (2014): 144–52. http://dx.doi.org/10.1142/s2339547814500137.

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Keloid is a long-term dermatological scarring disease characterized by disfiguring lesions resulting from overgrowth of dense fibrous tissue. Current therapeutics are ineffective, require clinical supervision and can be costly. This study investigated the use of microneedle technology in the self-management of keloid lesions. Specifically, a microneedle patch comprising of polyethylene glycol diacrylate (PEGDA) and encapsulating 5-fluorouracil (5-FU) has been developed for transdermal delivery. The microneedle patches showed requisite mechanical strength (hardness 45 ± 11 MPa, elastic modulus

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Pundir, Gaurav, Srishti Morris, Vikash Jakhmola, and Tarun Parashar Parashar. "Microneedle Transdermal Patches- A Novel Painless Approach with Improved Bioavailability for the Treatment of Diseases with Special Prevalence to Neonatal Infection." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1749–57. http://dx.doi.org/10.25258/ijddt.14.3.71.

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Microneedle transdermal drug delivery systems (TDDS) present a compelling substitute for parenteral and oral administration methods in the treatment of several illnesses. The past several decades have seen a revolution in technology that has changed the production of micro-structured devices, including the development of microneedles for transdermal patches. These devices are used to deliver drugs, proteins, insulin, antibiotics, vaccinations, and other therapies through the skin. They are proven to be beneficial for the prevention of newborn infections. Successful treatments for conditions li

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Olowe, Michael, Santosh Kumar Parupelli, and Salil Desai. "A Review of 3D-Printing of Microneedles." Pharmaceutics 14, no. 12 (2022): 2693. http://dx.doi.org/10.3390/pharmaceutics14122693.

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Microneedles are micron-sized devices that are used for the transdermal administration of a wide range of active pharmaceutics substances with minimally invasive pain. In the past decade, various additive manufacturing technologies have been used for the fabrication of microneedles; however, they have limitations due to material compatibility and bioavailability and are time-consuming and expensive processes. Additive manufacturing (AM), which is popularly known as 3D-printing, is an innovative technology that builds three-dimensional solid objects (3D). This article provides a comprehensive r

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Du, Li Qun, Zhong Zhou Wang, Xiao Peng Ruan, Sheng Li Chen, and Qing Shan. "Fabrication of SU-8 Microneedle Based on Backside Exposure Technology." Key Engineering Materials 645-646 (May 2015): 853–58. http://dx.doi.org/10.4028/www.scientific.net/kem.645-646.853.

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An optimization method for fabricating 3D microneedle arrays with larger cone angles through backside exposure is demonstrated in this paper. A photo mask was designed to fabricate SU-8 microneedle based on diffraction of UV light. A circular hole diffraction was simulated with Matlab to obtain light intensity distribution. The simulation results show that the cone angles and surface profile can be adjusted by changing the thickness of substrate and exposure dose. Based on the simulation results, the microneedles with heights of 265 μm to 380 μm and cone angles in the range of 5.1° to 15.6° we

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Liu, Yun, Ruiyue Mao, Shijia Han, Zhi Yu, Bin Xu, and Tiancheng Xu. "Polymeric Microneedle Drug Delivery Systems: Mechanisms of Treatment, Material Properties, and Clinical Applications—A Comprehensive Review." Polymers 16, no. 18 (2024): 2568. http://dx.doi.org/10.3390/polym16182568.

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Our comprehensive review plunges into the cutting-edge advancements of polymeric microneedle drug delivery systems, underscoring their transformative potential in the realm of transdermal drug administration. Our scrutiny centers on the substrate materials pivotal for microneedle construction and the core properties that dictate their efficacy. We delve into the distinctive interplay between microneedles and dermal layers, underscoring the mechanisms by which this synergy enhances drug absorption and precision targeting. Moreover, we examine the acupoint–target organ–ganglion nexus, an innovat

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Diwe, I. V., H. E. Mgbemere, O. A. Adeleye, and I. C. Ekpe. "Polymeric microneedle arrays for transdermal rapid diagnostic tests and drug delivery: a review." Nigerian Journal of Technology 43, no. 2 (2024): 279–93. http://dx.doi.org/10.4314/njt.v43i2.11.

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In recent times, the demand for innovative, insignificantly invasive diagnostic and therapeutic biomedical tools has reached enhanced attention. Rapid Diagnostic Tests (RDTs) for diagnosis, which are non-invasive, inexpensive, simple, and deliver results accurately in less than 20 minutes, have heightened the accessibility to parasite-based analysis globally. Microneedle (MN) arrays are a fast-developing and promising technology for drug delivery and extraction of Interstitial fluid (ISF) employed for numerous diagnostic and clinical therapies. This review gives a broad overview of the charact

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Parhi, Rabinarayan, and Divya Supriya N. "Review of Microneedle based Transdermal Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 3 (2019): 4511–23. http://dx.doi.org/10.37285/ijpsn.2019.12.3.1.

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Transdermal drug delivery (TDD) provides an attractive and alternative drug delivery when compared to oral and other drug delivery as the former route offers several advantages like avoiding pre-systemic first pass metabolism of administered drugs, patient compliance, and avoiding gastric irritation. However, stratum corneum (SC), the upper most layer of skin, limits the permeation of number of drugs because of its barrier property. To breach or bypass this barrier, two approaches namely: chemical and physical are generally used. Physical approaches seem to be better as it does not involve the

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Ashraf, Muhammad Waseem, Shahzadi Tayyaba, Nitin Afzulpurkar, et al. "Optimization of Fabrication Process for MEMS Based Microneedles Using ICP Etching Technology." Advanced Materials Research 403-408 (November 2011): 4611–16. http://dx.doi.org/10.4028/www.scientific.net/amr.403-408.4611.

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In this paper, optimization of fabrication process for microneedles has been presented. Using inductively coupled plasma (ICP) etching technology, fabrication of out-of-plane hollow silicon microneedles for blood extraction has been carried out. Sharp tip microneedles with length 1100 µm were designed for fabrication. The fabrication of microneedles was not successful because the lumen section was fabricated first and then hole was created for fluid flow. Previously, using same fabrication method successful fabrication of microneedles was done for drug delivery with length 200 µm. This fabrica

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Voelcker, Nicolas, and Muamer Dervisevic. "(Invited) Microneedle Arrays Featuring Microcavities for Electrochemical Biosensing in Sweat and Interstitial Fluid." ECS Meeting Abstracts MA2025-01, no. 60 (2025): 2852. https://doi.org/10.1149/ma2025-01602852mtgabs.

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Microneedle arrays are a promising tool in the development of transdermal biosensing devices, and considerable research effort is being devoted to the development, microfabrication, optimization, and testing of different microneedle-based sensing platforms.[1] To date, microneedles have been fabricated from various materials in different shapes, sizes, and densities, with the aim of enhancing the performance of biosensors and developing user-friendly microneedle devices.[1] And we have demonstrated sensing of small molecules and macromolecules using both silicon and polymer based microneedle a

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Kulkarni, Deepak, Dipak Gadade, Nutan Chapaitkar, et al. "Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications." Scientia Pharmaceutica 91, no. 2 (2023): 27. http://dx.doi.org/10.3390/scipharm91020027.

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Microneedles are gaining popularity as a new paradigm in the area of transdermal drug delivery for biomedical and healthcare applications. Efficient drug delivery with minimal invasion is the prime advantage of microneedles. The concept of the microneedle array provides an extensive surface area for efficient drug delivery. Various types of inorganics (silicon, ceramic, metal, etc.) and polymeric materials are used for the fabrication of microneedles. The polymeric microneedles have various advantages over other microneedles fabricated using inorganic material, such as biocompatibility, biodeg

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Radmard, Ariana, and Ajay K. Banga. "Microneedle-Assisted Transdermal Delivery of Lurasidone Nanoparticles." Pharmaceutics 16, no. 3 (2024): 308. http://dx.doi.org/10.3390/pharmaceutics16030308.

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Lurasidone, an antipsychotic medication for schizophrenia, is administered daily via oral intake. Adherence is a critical challenge, given that many schizophrenia patients deny their condition, thus making alternative delivery methods desirable. This study aimed to deliver lurasidone by the transdermal route and provide therapeutic effects for three days. Passive diffusion was found to be insufficient for lurasidone delivery. The addition of chemical enhancers increased permeation, but it was still insufficient to reach the designed target dose from a patch, so a microneedle patch array was fa

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Bhumika, Patil* Suvarna Shelke. "Microneedles: A Novel Approach on Transdermal Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 491–502. https://doi.org/10.5281/zenodo.15335243.

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Transdermal drug delivery via microneedles is emerging as a more effective alternative to traditional oral medication routes. Oral delivery often faces challenges such as exposure to stomach acid and digestive enzymes, leading to drug denaturation and poor effectiveness. Microneedle technology addresses these issues by delivering drugs through the skin, bypassing the gastrointestinal tract. This method also helps patients who experience discomfort from injections, improving overall compliance. There are five main types of microneedles: solid, coated, dissolving, hollow, and hydrogel forming. E

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Kulkarni, Deepak, Fouad Damiri, Satish Rojekar, et al. "Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications." Pharmaceutics 14, no. 5 (2022): 1097. http://dx.doi.org/10.3390/pharmaceutics14051097.

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Microneedle (MNs) technology is a recent advancement in biomedical science across the globe. The current limitations of drug delivery, like poor absorption, low bioavailability, inadequate skin permeation, and poor biodistribution, can be overcome by MN-based drug delivery. Nanotechnology made significant changes in fabrication techniques for microneedles (MNs) and design shifted from conventional to novel, using various types of natural and synthetic materials and their combinations. Nowadays, MNs technology has gained popularity worldwide in biomedical research and drug delivery technology d

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Yan, Xiao Xiao, Jing Quan Liu, Long Fei Wang, Chun Sheng Yang, and Yi Gui Li. "Silicon-Based Microneedle Array Electrodes for Biopotential Measurement." Key Engineering Materials 483 (June 2011): 443–46. http://dx.doi.org/10.4028/www.scientific.net/kem.483.443.

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Biopotential signals in shin tissue reflect the body’s healthy conditions. So the measurement of these signals can diagnose whether the body has diseases or not. Traditional technology used to measure these signals results in pain, bleeding, infection, etc. Recently, the microneedle electrodes are used to measure these signals owing to their advantages, such as painless, low cost, easily made, etc. This paper presents a new method to fabricate the silicon-based microneedle array electrodes intended for measuring biopotential signals in the skin tissue. The arrays consist of a 5 mm x 5 mm silic

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Yu, Xueqing, Jing Zhao, and Daidi Fan. "The Progress in the Application of Dissolving Microneedles in Biomedicine." Polymers 15, no. 20 (2023): 4059. http://dx.doi.org/10.3390/polym15204059.

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In recent years, microneedle technology has been widely used for the transdermal delivery of substances, showing improvements in drug delivery effects with the advantages of minimally invasive, painless, and convenient operation. With the development of nano- and electrochemical technology, different types of microneedles are increasingly being used in other biomedical fields. Recent research progress shows that dissolving microneedles have achieved remarkable results in the fields of dermatological treatment, disease diagnosis and monitoring, and vaccine delivery, and they have a wide range o

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Chan, Victoria, and Steven Wong. "Microneedle patch vaccine." University of Western Ontario Medical Journal 85, no. 2 (2016): 69–71. http://dx.doi.org/10.5206/uwomj.v85i2.4149.

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Vaccinations are an important means of controlling communicable diseases, especially in developing countries where patients do not have regular access to adequate healthcare. However, barriers such as cost and lack of resources are particularly problematic in the developing world and limit the adoption of vaccines. Meanwhile, in developed nations, the fear of injections contributes to the growing problem of vaccine avoidance and hesitancy. To address these barriers, a microneedle patch vaccine was recently created by Dr Prausnitz and his research team at the Georgia Institute of Technology in

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Salih, Omar S., and Entidhar J. Al-akkam. "Microneedles as A Magical Technology to facilitate Transdermal Drug Delivery: A Review Article." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 02 (2022): 896–901. http://dx.doi.org/10.25258/ijddt.12.2.76.

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Skin drug administration is the method used to provide drugs for local or systemic therapy, which is recognized for clinical usage. It is the third-largest method of medication delivery, after only intravenous administration and oral administration. Using a transdermal delivery method makes the administration easy, and blood concentration and adverse effects can be reduced. A microneedle is a micron-sized needle with a short height of no more than 500 micrometers and a width of no more than 50 micrometers. The needle comes into contact with the epidermal layer of the skin before it gets to the

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Yamagishi, Rio, Sayaka Miura, Kana Yabu, et al. "Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold." Gels 10, no. 1 (2024): 65. http://dx.doi.org/10.3390/gels10010065.

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Microneedles are of great interest in diverse fields, including cosmetics, drug delivery systems, chromatography, and biological sensing for disease diagnosis. Self-dissolving ultrafine microneedles of pure sodium hyaluronate hydrogels were fabricated using a UV-curing TiO2-SiO2 gas-permeable mold polymerized by sol-gel hydrolysis reactions in nanoimprint lithography processes under refrigeration at 5 °C, where thermal decomposition of microneedle components can be avoided. The moldability, strength, and dissolution behavior of sodium hyaluronate hydrogels with different molecular weights were

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Lim, Dong-Jin, and Hong-Jun Kim. "Microneedles in Action: Microneedling and Microneedles-Assisted Transdermal Delivery." Polymers 14, no. 8 (2022): 1608. http://dx.doi.org/10.3390/polym14081608.

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Human skin is a multilayered physiochemical barrier protecting the human body. The stratum corneum (SC) is the outermost keratinized layer of skin through which only molecules with less or equal to 500 Da (Dalton) in size can freely move through the skin. Unfortunately, the conventional use of a hypothermic needle for large therapeutic agents is susceptible to needle phobia and the risk of acquiring infectious diseases. As a new approach, a microneedle (MN) can deliver therapeutically significant molecules without apparent limitations associated with its molecular size. Microneedles can create

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Li, Yulin. "Brief Description and Application of Microneedle Biosensors." Highlights in Science, Engineering and Technology 55 (July 9, 2023): 211–16. http://dx.doi.org/10.54097/hset.v55i.9961.

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In recent years, tremendous advances have been made in microneedle (MN)-based biosensors. MN biosensors have been used as devices for developing non-invasive, continuous monitoring of patient health status due to their painless, non-blood contact characteristics. The development of biosensors based on an integrated microneedle platform for the detection of biomarkers in interstitial fluid is covered in this article. The combination of microneedle platforms with biosensors continues to create new opportunities for non-invasive detection and ongoing monitoring. The classification of MN microneed

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Qi, Zhenzhen, Jiaxin Cao, Xiaosheng Tao, Xinyi Wu, Subhas C. Kundu, and Shenzhou Lu. "Silk Fibroin Microneedle Patches for the Treatment of Insomnia." Pharmaceutics 13, no. 12 (2021): 2198. http://dx.doi.org/10.3390/pharmaceutics13122198.

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As a patient-friendly technology, drug-loaded microneedles can deliver drugs through the skin into the body. This system has broad application prospects and is receiving wide attention. Based on the knowledge acquired in this work, we successfully developed a melatonin-loaded microneedle prepared from proline/melatonin/silk fibroin. The engineered microneedles’ morphological, physical, and chemical properties were characterized to investigate their structural transformation mechanism and transdermal drug-delivery capabilities. The results indicated that the crystal structure of silk fibroin in

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Vijay, A. Shivnani. "The Role of Cnidocytes in Transdermal Drug Delivery: A Systematic Review." International Journal of Pharmaceutical and Clinical Research 16, no. 1 (2024): 56–62. https://doi.org/10.5281/zenodo.11091300.

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Cnidaria is a water-dwelling phylum characterized by a cnidocyte stinging cell. In nature, cnidocytes are used to immobilize or “sting” prey, for defense, and for locomotion, but their mechanisms also hold implications for drug delivery. Oral drug delivery has limitations that warrant new drug delivery techniques. One prominent method, transdermal drug delivery, uses the skin as a drug administration platform. Drugs can be systemically absorbed through microcirculation after relatively less invasive, painless, and self-administered delivery through ointments, creams, patches, and m

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Zhang, Lifan, Yinghong Chen, Jiayu Tan, Shuo Feng, Yeping Xie, and Li Li. "Performance Enhancement of PLA-Based Blend Microneedle Arrays through Shish-Kebab Structuring Strategy in Microinjection Molding." Polymers 15, no. 10 (2023): 2234. http://dx.doi.org/10.3390/polym15102234.

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Poly(lactic acid) (PLA) microneedles have been explored extensively, but the current regular fabrication strategy, such as thermoforming, is inefficient and poorly conformable. In addition, PLA needs to be modified as the application of microneedle arrays made of pure PLA is limited because of their easy tip fracture and poor skin adhesion. For this purpose, in this article, we reported a facile and scalable strategy to fabricate the microneedle arrays of the blend of PLA matrix and poly(p-dioxanone) (PPDO) dispersed phase with complementary mechanical properties through microinjection molding

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Qi, Zhenzhen, Zheng Yan, Guohongfang Tan, Subhas C. Kundu, and Shenzhou Lu. "Smart Responsive Microneedles for Controlled Drug Delivery." Molecules 28, no. 21 (2023): 7411. http://dx.doi.org/10.3390/molecules28217411.

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As an emerging technology, microneedles offer advantages such as painless administration, good biocompatibility, and ease of self-administration, so as to effectively treat various diseases, such as diabetes, wound repair, tumor treatment and so on. How to regulate the release behavior of loaded drugs in polymer microneedles is the core element of transdermal drug delivery. As an emerging on-demand drug-delivery technology, intelligent responsive microneedles can achieve local accurate release of drugs according to external stimuli or internal physiological environment changes. This review foc

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