Academic literature on the topic 'Microswimmers'

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Journal articles on the topic "Microswimmers"

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Chennaram, S. Sharanya, and T. Sonamani Singh. "Bidirectional Propulsion of Bioinspired Microswimmer in Microchannel at Low Reynolds Number." Journal of Physics: Conference Series 2663, no. 1 (December 1, 2023): 012035. http://dx.doi.org/10.1088/1742-6596/2663/1/012035.

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Abstract Swimming of micro-scale bodies is different from macro-scale counterparts due to low Reynolds number (Re) fluid-swimmer interaction. The Re is defined as the ratio of inertial force to viscous force and it can be expressed as, Re =ρ𝑣𝑙/µ, where ρ and µ are the density and viscosity of the fluid medium, v and l are the velocity and length of the swimmer. For microswimmers, due to the small length scale Re < 1, the inertial forces are negligible compared to viscous forces. Unlike the macroscale swimmers which exploit the inertial force for locomotion, microswimmers must use a different strategy to propel in low Re condition. These strategies are already available and used by microorganisms, which are perfect low Re swimmers, for example, Spermatozoon exploits their tail flexibility and anisotropic drag to swim, and E. coli bacteria use their helical tail to generate a non-reciprocal motion. By mimicking these microswimmers, researchers have developed many bioinspired microswimmers/microrobots having the potential to perform biomedical tasks like drug delivery, cell manipulation, in-situ sensing, and detoxification. Theoretical modeling and simulation of microswimmers are generally done by assuming that the microswimmer is in an infinite fluid medium, but the type of biomedical applications aimed are in confined environments with boundaries. Also, the environments are very complex, and it requires precise control and efficacy. In this paper, we present the modeling of flagellated magnetic microswimmer (inspired by Spermatozoon) in a microchannel using the finite element method. The dynamics were simulated by incorporating the complete hydrodynamic interactions (HI), that is intra-HI between the parts of the swimmer and inter-HI between the swimmer and the boundary walls of the channel. The parametric dependence analysis reveals that swimmer kinematics are dependent on the length and width of the tail, the head radius, width of the channel, and the actuation frequency of the driving magnetic field. These dependencies are explored to find a navigation control mechanism for the propulsion of microswimmer in a channel.
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Bunea, Ada-Ioana, and Rafael Taboryski. "Recent Advances in Microswimmers for Biomedical Applications." Micromachines 11, no. 12 (November 27, 2020): 1048. http://dx.doi.org/10.3390/mi11121048.

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Microswimmers are a rapidly developing research area attracting enormous attention because of their many potential applications with high societal value. A particularly promising target for cleverly engineered microswimmers is the field of biomedical applications, where many interesting examples have already been reported for e.g., cargo transport and drug delivery, artificial insemination, sensing, indirect manipulation of cells and other microscopic objects, imaging, and microsurgery. Pioneered only two decades ago, research studies on the use of microswimmers in biomedical applications are currently progressing at an incredibly fast pace. Given the recent nature of the research, there are currently no clinically approved microswimmer uses, and it is likely that several years will yet pass before any clinical uses can become a reality. Nevertheless, current research is laying the foundation for clinical translation, as more and more studies explore various strategies for developing biocompatible and biodegradable microswimmers fueled by in vivo-friendly means. The aim of this review is to provide a summary of the reported biomedical applications of microswimmers, with focus on the most recent advances. Finally, the main considerations and challenges for clinical translation and commercialization are discussed.
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Xiong, Junfeng, Xiaoxia Song, Yuhang Cai, Jiahe Liu, Yangyuan Li, Yaqiang Ji, Liang Guo, and U. Kei Cheang. "Stop-Flow Lithography for the Continuous Production of Degradable Hydrogel Achiral Crescent Microswimmers." Micromachines 13, no. 5 (May 20, 2022): 798. http://dx.doi.org/10.3390/mi13050798.

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The small size of robotic microswimmers makes them suitable for performing biomedical tasks in tiny, enclosed spaces. Considering the effects of potentially long-term retention of microswimmers in biological tissues and the environment, the degradability of microswimmers has become one of the pressing issues in this field. While degradable hydrogel was successfully used to prepare microswimmers in previous reports, most hydrogel microswimmers could only be fabricated using two-photon polymerization (TPP) due to their 3D structures, resulting in costly robotic microswimmers solution. This limits the potential of hydrogel microswimmers to be used in applications where a large number of microswimmers are needed. Here, we proposed a new type of preparation method for degradable hydrogel achiral crescent microswimmers using a custom-built stop-flow lithography (SFL) setup. The degradability of the hydrogel crescent microswimmers was quantitatively analyzed, and the degradation rate in sodium hydroxide solution (NaOH) of different concentrations was investigated. Cytotoxicity assays showed the hydrogel crescent microswimmers had good biocompatibility. The hydrogel crescent microswimmers were magnetically actuated using a 3D Helmholtz coil system and were able to obtain a swimming efficiency on par with previously reported microswimmers. The results herein demonstrated the potential for the degradable hydrogel achiral microswimmers to become a candidate for microscale applications.
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Sun, Zhiyong, Philipp F. Popp, Christoph Loderer, and Ainhoa Revilla-Guarinos. "Genetically Engineered Bacterial Biohybrid Microswimmers for Sensing Applications." Sensors 20, no. 1 (December 28, 2019): 180. http://dx.doi.org/10.3390/s20010180.

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Bacterial biohybrid microswimmers aim at exploiting the inherent motion capabilities of bacteria (carriers) to transport objects (cargoes) at the microscale. One of the most desired properties of microswimmers is their ability to communicate with their immediate environment by processing the information and producing a useful response. Indeed, bacteria are naturally equipped with such communication skills. Hereby, two-component systems (TCSs) represent the key signal transducing machinery and enable bacteria to sense and respond to a variety of stimuli. We engineered a natural microswimmer based on the Gram-positive model bacterium Bacillus subtilis for the development of biohybrids with sensing abilities. B. subtilis naturally adhered to silica particles, giving rise to different motile biohybrids systems with variable ratios of carrier(s)-to-cargo(es). Genetically engineered TCS pathways allowed us to couple the binding to the inert particles with signaling the presence of antibiotics in their surroundings. Activation of the antibiotic-induced TCSs resulted in fluorescent bacterial carriers as a response readout. We demonstrate that the genetically engineered TCS-mediated signaling capabilities of B. subtilis allow for the custom design of bacterial hybrid microswimmers able to sense and signal the presence of target molecules in the environment. The generally recognized as safe (GRAS) status of B. subtilis makes it a promising candidate for human-related applications of these novel biohybrids.
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Tan, Liyuan, Zihan Wang, Zhi Chen, Xiangcheng Shi, and U. Kei Cheang. "Improving Swimming Performance of Photolithography-Based Microswimmers Using Curvature Structures." Micromachines 13, no. 11 (November 12, 2022): 1965. http://dx.doi.org/10.3390/mi13111965.

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The emergence of robotic microswimmers and their huge potential in biomedical applications such as drug delivery, non-invasive surgery, and bio-sensing facilitates studies to improve their effectiveness. Recently, achiral microswimmers that have neither flexible nor helical structures have garnered attention because of their simple structures and fabrication process while preserving adequate swimming velocity and controllability. In this paper, the crescent shape was utilized to create photolithography-fabricated crescent-shaped achiral microswimmers. The microswimmers were actuated using rotating magnetic fields at low Reynolds numbers. Compared with the previously reported achiral microswimmers, the crescent-shaped microswimmers showed significant improvement in forward swimming speed. The effects of different curvatures, arm angles, and procession angles on the velocities of microswimmers were investigated. Moreover, the optimal swimming motion was defined by adjusting the field strength of the magnetic field. Finally, the effect of the thickness of the microswimmers on their swimming velocity was investigated.
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Hartl, Benedikt, Maximilian Hübl, Gerhard Kahl, and Andreas Zöttl. "Microswimmers learning chemotaxis with genetic algorithms." Proceedings of the National Academy of Sciences 118, no. 19 (May 4, 2021): e2019683118. http://dx.doi.org/10.1073/pnas.2019683118.

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Various microorganisms and some mammalian cells are able to swim in viscous fluids by performing nonreciprocal body deformations, such as rotating attached flagella or by distorting their entire body. In order to perform chemotaxis (i.e., to move toward and to stay at high concentrations of nutrients), they adapt their swimming gaits in a nontrivial manner. Here, we propose a computational model, which features autonomous shape adaptation of microswimmers moving in one dimension toward high field concentrations. As an internal decision-making machinery, we use artificial neural networks, which control the motion of the microswimmer. We present two methods to measure chemical gradients, spatial and temporal sensing, as known for swimming mammalian cells and bacteria, respectively. Using the genetic algorithm NeuroEvolution of Augmenting Topologies, surprisingly simple neural networks evolve. These networks control the shape deformations of the microswimmers and allow them to navigate in static and complex time-dependent chemical environments. By introducing noisy signal transmission in the neural network, the well-known biased run-and-tumble motion emerges. Our work demonstrates that the evolution of a simple and interpretable internal decision-making machinery coupled to the environment allows navigation in diverse chemical landscapes. These findings are of relevance for intracellular biochemical sensing mechanisms of single cells or for the simple nervous system of small multicellular organisms such as Caenorhabditis elegans.
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Kroy, Klaus, Dipanjan Chakraborty, and Frank Cichos. "Hot microswimmers." European Physical Journal Special Topics 225, no. 11-12 (November 2016): 2207–25. http://dx.doi.org/10.1140/epjst/e2016-60098-6.

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Singh, Dhruv P., William E. Uspal, Mihail N. Popescu, Laurence G. Wilson, and Peer Fischer. "Photogravitactic Microswimmers." Advanced Functional Materials 28, no. 25 (February 28, 2018): 1706660. http://dx.doi.org/10.1002/adfm.201706660.

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Tan, Liyuan, Jamel Ali, U. Kei Cheang, Xiangcheng Shi, Dalhyung Kim, and Min Jun Kim. "µ-PIV Measurements of Flows Generated by Photolithography-Fabricated Achiral Microswimmers." Micromachines 10, no. 12 (December 10, 2019): 865. http://dx.doi.org/10.3390/mi10120865.

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Robotic micro/nanoswimmers can potentially be used as tools for medical applications, such as drug delivery and noninvasive surgery. Recently, achiral microswimmers have gained significant attention because of their simple structures, which enables high-throughput fabrication and size scalability. Here, microparticle image velocimetry (µ-PIV) was used to study the hydrodynamics of achiral microswimmers near a boundary. The structures of these microswimmers resemble the letter L and were fabricated using photolithography and thin-film deposition. Through µ-PIV measurements, the velocity flow fields of the microswimmers rotating at different frequencies were observed. The results herein yield an understanding of the hydrodynamics of the L-shaped microswimmers, which will be useful in applications such as fluidic manipulation.
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Giri, Pritam, and Ratnesh K. Shukla. "Optimal transport of surface-actuated microswimmers." Physics of Fluids 34, no. 4 (April 2022): 043604. http://dx.doi.org/10.1063/5.0083277.

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We analyze the transport behavior of surface-actuated spheroidal microswimmers that locomote steadily with or without a spatiotemporally uniform external forcing. The surface actuation is in the form of either a tangential surface motion or a zero-net-mass-flux wall-normal transpiration. Starting from a general modal expansion in terms of an appropriate basis set, we link the surface actuation, the force exerted on the spheroid, and its forward speed through a Stokesian representation of the microhydrodynamics. Our analysis is generic and enables a systematic investigation over the complete range of aspect ratios from zero (streamlined needlelike spheroid) to infinity (disc-shaped spheroid). We identify a critical aspect ratio of 1.82 below and above which tangential and wall-normal surface actuations enable transport at minimal energetic cost, irrespective of whether the spheroidal microswimmer is free or forced. Crucially, we find the propulsive performance of a forced spheroidal swimmer to be appreciably higher than the one of an analogous self-propelled swimmer. Most importantly, the optimal energy expenditure minimizing tangential or wall-normal surface actuation for forced transport is passive overall so that the power requirement arises solely from the rate at which work is done by the external forcing. We highlight the complementing roles of external forcing and surface actuation over moderate and extreme aspect ratios and also exemplify the crucial disparities between optimal transport in free and forced environments. Our results indicate that a combination of external forcing and an optimal surface actuation could substantially enhance the transport of generic streamlined and bluff microswimmers.
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Dissertations / Theses on the topic "Microswimmers"

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Putz, Victor B. "Collective behaviour of model microswimmers." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:2018148e-336d-4be2-8c8c-c40278bb2d90.

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At small length scales, low velocities, and high viscosity, the effects of inertia on motion through fluid become insignificant and viscous forces dominate. Microswimmer propulsion, of necessity, is achieved through different means than that achieved by macroscopic organisms. We describe in detail the hydrodynamics of microswimmers consisting of colloidal particles and their interactions. In particular we focus on two-bead swimmers and the effects of asymmetry on collective motion, calculating analytical formulae for time-averaged pair interactions and verifying them with microscopic time-resolved numerical simulation, finding good agreement. We then examine the long-term effects of a swimmer's passing on a passive tracer particle, finding that the force-free nature of these microswimmers leads to loop-shaped tracer trajectories. Even in the presence of Brownian motion, the loop-shaped structures of these trajectories can be recovered by averaging over a large enough sample size. Finally, we explore the phenomenon of synchronisation between microswimmers through hydrodynamic interactions, using the method of constraint forces on a force-based swimmer. We find that the hydrodynamic interactions between swimmers can alter the relative phase between them such that phase-locking can occur over the long term, altering their collective motion.
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Oyama, Norihiro. "Direct Numerical Calculation on the Collective Motion of Model Microswimmers." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225640.

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Xu, Tiantian. "Propulsion Characteristics and Visual Servo Control of Scaled-up Helical Microswimmers." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2014. http://tel.archives-ouvertes.fr/tel-00977906.

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L'utilisation de micronageurs hélicoidaux capables de se mouvoir dans des liquides à faible nombre de Reynolds trouve son intérêt dans beaucoup d'applications: de tâches in-vitro dans des laboratoires sur puce (transport et tri de micro-objets; assemblage de micro-composants...), à des applications in-vivo en médecine mini-invasive (livraison interne et ciblée de médicaments, curiethérapie, thermothérapie...); grace à leur dimensions microscopiques et agilité permettant l'accès à des endroits normalement très restreints. Plusieurs types de nageurs hélicoidaux actionnés magnétiquement possédant divers paramètres géométriques, formes de tête et positions de la partie magnétique ont été proposés dans de précédents travaux. Cependant, l'influence de tous ces paramètres n'a pas clairement été étudiée. À notre connaissance, les micronageurs hélicoidaux dans l'état de l'art sont principalement contrôlés en boucle ouverte, en raison de la complexité de la commande du champ magnétique actionnant la propulsion, et du nombre limité de retours ayant des critères satisfaisants. Cette thèse vise à: comparer les performances de déplacement de nageurs hélicoidaux avec des conceptions différentes afin d'améliorer leur design et de les caractériser, et réaliser un asservissement visual de nageur hélicoidal. Pour se faire, des nageurs hélicoidaux de tailles millimétriques ont été conçus et sont mis en conditions à faible nombre de Reynolds. La conception de ces "millinageurs" servira de base à la conception de micronageurs. Une commande boucle fermée par retour visuel de l'orientation d'un micronageur hélicoidal dans un espace 3D, et un suivi de trajectoires sur plan horizontal ont été effectués. Cette méthode de commande sera par la suite appliquée à des micronageurs hélicoidaux.
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Rode, Sebastian [Verfasser], Gerhard Gutachter] Gompper, and Ulrich Benjamin [Gutachter] [Kaupp. "Flagellated and Ciliated Microswimmers / Sebastian Rode ; Gutachter: Gerhard Gompper, Benjamin Kaupp." Köln : Universitäts- und Stadtbibliothek Köln, 2017. http://d-nb.info/1161096825/34.

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Rode, Sebastian Verfasser], Gerhard [Gutachter] Gompper, and Ulrich Benjamin [Gutachter] [Kaupp. "Flagellated and Ciliated Microswimmers / Sebastian Rode ; Gutachter: Gerhard Gompper, Benjamin Kaupp." Köln : Universitäts- und Stadtbibliothek Köln, 2017. http://d-nb.info/1161096825/34.

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Chawan, Aschvin Bhagirath. "Novel methods for microfluidic mixing and control." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/54016.

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Microfluidics is a constantly evolving area of research. The implementation of new technologies and fabrication processes offers novel methodologies to solve existing problems. There are currently a large number of established techniques to address issues associated with microscale mixing and valving. We present mixing and valving techniques that utilize simplified and inexpensive techniques. The first technique addresses issues associated with microscale mixing. Exercising control over animal locomotion is well known in the macro world but in the micro-scale world, control requires more sophistication. We present a method to artificially magnetize microorganisms and use external permanent magnets to control their motion in a microfluidic device. This effectively tethers the microorganisms to a location in the channel and controls where mixing occurs. We use the bulk and ciliary motion of the microswimmers to generate shear flows, thus enhancing cross-stream mixing by supplementing diffusion. The device is similar to an active mixer but requires no external power sources or artificial actuators. The second technique examines a methodology involving the integration of electroactive polymers into microfluidic devices. Under the influence of high applied voltages, electroactive polymers with fixed boundary conditions undergo out-of-plane deformation. We use this finding to create a valve capable blocking flow in microchannels. Electrolytic fluid solutions are used as electrodes to carry the voltage signal to the polymer surface. Currently we have demonstrated this methodology as a proof of concept, but aim to optimize our system to develop a robust microvalve technology.
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Geiseler, Alexander [Verfasser], and Peter [Akademischer Betreuer] Hänggi. "Artificial Microswimmers in Spatio-Temporally Modulated Activating Media / Alexander Geiseler ; Betreuer: Peter Hänggi." Augsburg : Universität Augsburg, 2018. http://d-nb.info/1156544718/34.

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Ives, Thomas Robert. "Microswimming in complex fluids." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31225.

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Many microorganisms have the ability to propel themselves through their fluid environments by periodically actuating their body. The biological fluid environments surrounding these microswimmers are typically complex fluids containing many high-molecular weight protein molecules, which give the fluid non-Newtonian rheological properties. In this thesis, we investigate the effect that one such rheological property, viscoelasticity, has on microswimming. We consider a classical model of a microswimmer, the so-called Taylor's waving sheet and generalise it to arbitrary shapes. We employ the Oldroyd-B model to study its swimming analytically and numerically. We attempt to develop a mechanistic understanding of the swimmer's behaviour in viscoelastic fluids. It has recently been suggested that continuum models of complex biological fluids might not be appropriate for studying the swimming of flagellated microorganisms as the size of biological macromolecules is comparable to the typical width of a microorganism's flagellum. A part of this thesis is devoted to exploring this scenario. We propose an alternative method for modelling complex fluids using a two-fluid depletion region model and we have developed a numerical solver to find the swimming speed and rate of work for the generalised Taylor's waving sheet model swimmer using this alternate depletion region model. This thesis is organised as follows. In the first chapter, we outline a physical mechanism for the slowing down of Taylor's sheet in an Oldroyd-B fluid as the Deborah number increases. We demonstrate how a microswimmer can be designed to avoid this. In the second chapter, we investigate swimming in an Oldroyd-B fluid near a solid boundary and show that, at large amplitudes and low polymer concentrations, the swimming speed of Taylor's sheet increases with De. In the third chapter, we show how the Oldroyd-B model can be adapted using depletion regions. In the final chapter, we investigate optimal swimming in a Newtonian fluid. We show that while the organism's energetics are important, the kinematics of planar-wave microswimmers do not optimise the hydrodynamic 'efficiency' typically used for mathematical optimisation in the literature.
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Jahanshahi, Soudeh [Verfasser], Hartmut [Gutachter] Löwen, and Alexei [Gutachter] Ivlev. "Microswimmers and microflyers in various complex environments / Soudeh Jahanshahi ; Gutachter: Hartmut Löwen, Alexei Ivlev." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1201881935/34.

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Wagner, Martin [Verfasser], Gerhard [Gutachter] Gompper, Ulrich K. [Gutachter] Deiters, and Marisol [Gutachter] Ripoll. "Colloidal Microswimmers driven by Thermophoresis / Martin Wagner ; Gutachter: Gerhard Gompper, Ulrich K. Deiters, Marisol Ripoll." Köln : Universitäts- und Stadtbibliothek Köln, 2017. http://d-nb.info/114862368X/34.

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Book chapters on the topic "Microswimmers"

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Zoppello, Marta, Antonio DeSimone, François Alouges, Laetitia Giraldi, and Pierre Martinon. "Optimal Control of Slender Microswimmers." In Lecture Notes in Computational Science and Engineering, 161–82. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-73371-5_8.

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Subbaraju, Sree Gayathri, Usha Chockaiyan, Sakthieaswari Pandi, Aarthy Kannan, and Muthupandian Saravanan. "Nanoerythrosome-Biohybrid Microswimmers for Cancer Theranostics Cargo Delivery." In Nanotechnology in the Life Sciences, 261–84. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-76263-6_10.

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Subbaraju, Sree Gayathri, Usha Chockaiyan, Sakthieaswari Pandi, Aarthy Kannan, and Muthupandian Saravanan. "Nanoerythrosome-Biohybrid Microswimmers for Cancer Theranostics Cargo Delivery." In Nanotechnology in the Life Sciences, 261–84. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-76263-6_10.

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Dutta, Sayan Deb, Keya Ganguly, Dinesh K. Patel, Tejal V. Patil, Rachmi Luthfikasari, and Ki-Taek Lim. "Printable Nanorobots and Microswimmers for Therapeutic Advancement: Present Status and Future Opportunities." In Nanorobotics and Nanodiagnostics in Integrative Biology and Biomedicine, 53–78. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-16084-4_4.

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Altemose, A., and A. Sen. "Chapter 11. Collective Behaviour of Artificial Microswimmers in Response to Environmental Conditions." In Theoretical and Computational Chemistry Series, 250–83. Cambridge: Royal Society of Chemistry, 2018. http://dx.doi.org/10.1039/9781788013499-00250.

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Sonamani Singh, T., and R. D. S. Yadava. "Effect of Tapering on Swimming Efficiency of Flagellated Microswimmer at Low Reynolds Number." In Advances in Intelligent Systems and Computing, 627–37. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8237-5_61.

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Dreyfus, Remy. "Flexible Magnetic Microswimmers." In Microbiorobotics, 211–47. Elsevier, 2012. http://dx.doi.org/10.1016/b978-1-4557-7891-1.00009-8.

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Agrawal, Naveen Kumar, Pallab Sinha Mahapatra, and Tuhin S. Santra. "Micro-Robots/Microswimmers for Biomedical Applications." In Microfluidics and Bio-MEMS, 95–148. Jenny Stanford Publishing, 2020. http://dx.doi.org/10.1201/9781003014935-3.

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Cheang, U. Kei, Dejan Milutinović, Jongeun Choi, and MinJun Kim. "Control of three bead achiral robotic microswimmers." In Microbiorobotics, 115–31. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-32-342993-1.00014-8.

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Yeomans, Julia M. "Active Nematics: Mesoscale Turbulence and Self-propelled Topological Defects." In Out-of-equilibrium Soft Matter, 88–106. The Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781839169465-00088.

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This chapter describes the properties of dense active nematics. We start by summarising the continuum theory of active nematics, introducing the active stress and showing how it results in mesoscale turbulence and motile topological defects. Relevant experimental systems are suspensions of microtubules driven by motor proteins and crowded microswimmers, and we compare experimental and numerical results in bulk, in confinement, and in the presence of friction. We then consider the extent to which the behaviour of other biological systems, such as crawling bacteria or epithelial cells, can be interpreted in terms of active nematic physics.
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Conference papers on the topic "Microswimmers"

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Cheang, U. Kei, Milutinović Dejan, Jongeun Choi, and Minjun Kim. "Towards Model-Based Control of Achiral Microswimmers." In ASME 2014 Dynamic Systems and Control Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/dscc2014-6136.

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In this paper, we introduce the three bead achiral microswimmers controlled wirelessly using magnetic fields with the ability to swim in bulk fluid. The achirality of the microswimmer introduces unknown handedness of the microswimmer. Here, we propose to use a combination of rotating and static magnetic fields to eliminate the uncertainty in swimming direction. Our experimental results demonstrated excellent capability of direction control as well as agile movements. From the experimentally collected data, we estimated a control-oriented two-wheeled robot model. Finally, we design feedback control for microswimmers based on the estimated kinematic model. In particular, we show that the feedback control law moves the microswimmer from any initial conditions to a target set of microswimmer’s position and angle.
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Cheang, U. Kei, Jun Hee Lee, Paul Kim, and Min Jun Kim. "Magnetic Control of Biologically Inspired Robotic Microswimmers." In ASME-JSME-KSME 2011 Joint Fluids Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/ajk2011-19014.

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Bacterial flagella have been employed as nanoactuators for biomimetic microswimmers in low Reynolds number fluidic environments. The microswimmer is a dumbbell-like swimmer that utilizes flagellar hydrodynamics to achieve spiral-type swimming. Flagellar filaments from Salmonella typhimurium are harnessed and functionalized in order to serve as couplers for polystyrene (PS) microbeads and magnetic nanoparticles (MNPs) using avidin-biotin chemistry. The MNP have an iron oxide core that will allow us to actuate the microswimmer under a rotating magnetic field. Using a micromanufacturing process, microswimmer of different configurations can be created to mimic mono- and multi-flagellated bacteria. A magnetic control system consists of electromagnetic coils arranged in an approximate Helmholtz configuration was designed, constructed, and characterized. In conjunction with a LabVIEW input interface, a DAQ controller was used as a function generator to generate sinusoidal waveforms to the power supplies. AC current outputs were supplied from the power supplies to the coils in order to generate a rotating magnetic field. A rotating magnetic field will induce rotation in the flagella conjugated MNP which in term will rotate the flagellar filament into a spiral configuration and achieve propulsion, as in polarly-flagellated bacteria. A high-speed camera provided real-time imaging of the microswimmer motion in a static fluidic environment inside a closed PDMS (Polydimethylsiloxane) chamber. The microswimmers exhibited flagellar propulsion in a low Reynolds number fluidic environment under a rotating magnetic field, which demonstrates its potential for biomedical applications.
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3

Scogna, J., J. Olkowski, N. Fatema, P. Parameswaran, and V. Dhillon. "Biologically inspired robotic microswimmers." In 2011 37th Annual Northeast Bioengineering Conference (NEBEC). IEEE, 2011. http://dx.doi.org/10.1109/nebc.2011.5778554.

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Hesse, William R., Matthew Federici, David M. Casale, Peter Fink, Basil Milton, and Min Jun Kim. "Biologically Inspired Robotic Microswimmers." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-10565.

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Drug delivery systems have had a profound impact on several branches of medicine. Engineers and researchers alike have labored to create a controlled drug delivery device capable of regulated dosage release and a specific cell targeting mechanism. The growing field of biomimicry has inspired several of these drug systems, though success has been limited. The flagellated low Reynolds number propulsion system of Salmonella typhimurium has inspired this specific delivery complex. In this system, the helical flagellar filaments of S. typhimurium are isolated from the bacteria’s cell body and are bound to functionalized paramagnetic microspheres. As a magnetic field is applied to this device, the microsphere rotates, inducing rotation of the helical flagella. This motion creates a locomotive force and drives the device in a predestined direction.
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Maharjan, S., X. Wang, and F. Cichos. "Propulsion of microswimmers with delay." In Optical Manipulation and Its Applications. Washington, D.C.: OSA, 2021. http://dx.doi.org/10.1364/oma.2021.am1d.5.

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6

Pradip, Ravi, and Frank Cichos. "Deep reinforcement learning with artificial microswimmers." In Emerging Topics in Artificial Intelligence (ETAI) 2022, edited by Giovanni Volpe, Joana B. Pereira, Daniel Brunner, and Aydogan Ozcan. SPIE, 2022. http://dx.doi.org/10.1117/12.2633774.

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7

Isa, Lucio. "Breaking the symmetry: Designing colloidal microswimmers." In nanoGe Spring Meeting 2022. València: Fundació Scito, 2022. http://dx.doi.org/10.29363/nanoge.nsm.2022.250.

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8

Caldag, Hakan Osman, and Serhat Yesilyurt. "Dynamics of Artificial Helical Microswimmers Under Confinement." In ASME 2018 16th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icnmm2018-7632.

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Understanding trajectories of natural and artificial helical swimmers under confinement is important in biology and for controlled swimming in potential medical applications. Swimmers follow helical or straight trajectories depending on whether the helical tail is pushing or pulling the swimmer. To investigate swimming dynamics of helical swimmers further, we present a Computational Fluid Dynamics (CFD) model for simulation of an artificial microswimmer in cylindrical channels. The microswimmer has a cylindrical head and a left-handed helical tail. The kinematic model solves for the position and rotation of the swimmer based on the linear and angular velocities of the force-free swimmer from a CFD model. Third-order Adams-Bashforth solver is used to obtain the orientation and the position of the swimmer. Viscous, gravitational, magnetic and contact forces and torques are considered in the model. The model is validated with experimental results. 3D trajectories, propulsion and tangential velocities are reported.
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Buzhardt, Jake, and Phanindra Tallapragada. "Magnetically Actuated Artificial Microswimmers As Mobile Microparticle Manipulators." In ASME 2019 Dynamic Systems and Control Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/dscc2019-9015.

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Abstract Publisher’s Note: This paper was selected for publication in ASME Letters in Dynamic Systems and Control. https://www.asmedigitalcollection.asme.org/lettersdynsys/article/doi/10.1115/1.4046581/1075682/Magnetically-Actuated-Artificial-Microswimmers-as
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Würger, Alois. "Laser-heated microswimmers: optical manipulation of active particles." In Optical Manipulation and Structured Materials Conference, edited by Takashige Omatsu, Hajime Ishihara, Keiji Sasaki, and Kishan Dholakia. SPIE, 2020. http://dx.doi.org/10.1117/12.2573516.

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