Relevant bibliographies by topics / Microvascular constructs

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Microvascular constructs'

Author: Grafiati
Published: 4 June 2021
Last updated: 16 February 2022

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Journal articles on the topic "Microvascular constructs"

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Sukmana, Irza. "Microvascular Guidance: A Challenge to Support the Development of Vascularised Tissue Engineering Construct." Scientific World Journal 2012 (2012): 1–10. http://dx.doi.org/10.1100/2012/201352.

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The guidance of endothelial cell organization into a capillary network has been a long-standing challenge in tissue engineering. Some research efforts have been made to develop methods to promote capillary networks inside engineered tissue constructs. Capillary and vascular networks that would mimic blood microvessel function can be used to subsequently facilitate oxygen and nutrient transfer as well as waste removal. Vascularization of engineering tissue construct is one of the most favorable strategies to overpass nutrient and oxygen supply limitation, which is often the major hurdle in deve
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Fan, Rong, Yihang Sun, and Jiandi Wan. "Leaf-inspired artificial microvascular networks (LIAMN) for three-dimensional cell culture." RSC Advances 5, no. 110 (2015): 90596–601. http://dx.doi.org/10.1039/c5ra20265e.

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Vajda, Jernej, Marko Milojević, Uroš Maver, and Boštjan Vihar. "Microvascular Tissue Engineering—A Review." Biomedicines 9, no. 6 (2021): 589. http://dx.doi.org/10.3390/biomedicines9060589.

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Tissue engineering and regenerative medicine have come a long way in recent decades, but the lack of functioning vasculature is still a major obstacle preventing the development of thicker, physiologically relevant tissue constructs. A large part of this obstacle lies in the development of the vessels on a microscale—the microvasculature—that are crucial for oxygen and nutrient delivery. In this review, we present the state of the art in the field of microvascular tissue engineering and demonstrate the challenges for future research in various sections of the field. Finally, we illustrate the
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LeBlanc, Amanda J., Jeremy S. Touroo, James B. Hoying, and Stuart K. Williams. "Adipose stromal vascular fraction cell construct sustains coronary microvascular function after acute myocardial infarction." American Journal of Physiology-Heart and Circulatory Physiology 302, no. 4 (2012): H973—H982. http://dx.doi.org/10.1152/ajpheart.00735.2011.

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A three-dimensional tissue construct was created using adipose-derived stromal vascular fraction (SVF) cells and evaluated as a microvascular protection treatment in a myocardial infarction (MI) model. This study evaluated coronary blood flow (BF) and global left ventricular function after MI with and without the SVF construct. Fischer-344 rats were separated into four groups: sham operation (sham), MI, MI Vicryl patch (no cells), and MI SVF construct (MI SVF). SVF cells were labeled with green fluorescent protein (GFP). Immediately postinfarct, constructs were implanted onto the epicardium at
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Pedersen, Torbjorn O., Anna L. Blois, Zhe Xing, et al. "Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs." Stem Cell Research & Therapy 4, no. 3 (2013): 52. http://dx.doi.org/10.1186/scrt202.

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Underwood, Clayton J., Lowell T. Edgar, James B. Hoying, and Jeffrey A. Weiss. "Cell-generated traction forces and the resulting matrix deformation modulate microvascular alignment and growth during angiogenesis." American Journal of Physiology-Heart and Circulatory Physiology 307, no. 2 (2014): H152—H164. http://dx.doi.org/10.1152/ajpheart.00995.2013.

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The details of the mechanical factors that modulate angiogenesis remain poorly understood. Previous in vitro studies of angiogenesis using microvessel fragments cultured within collagen constructs demonstrated that neovessel alignment can be induced via mechanical constraint of the boundaries (i.e., boundary conditions). The objective of this study was to investigate the role of mechanical boundary conditions in the regulation of angiogenic alignment and growth in an in vitro model of angiogenesis. Angiogenic microvessels within three-dimensional constructs were subjected to different boundary
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Muscari, Claudio, Emanuele Giordano, Francesca Bonafè, Marco Govoni, and Carlo Guarnieri. "Strategies Affording Prevascularized Cell-Based Constructs for Myocardial Tissue Engineering." Stem Cells International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/434169.

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The production of a functional cardiac tissue to be transplanted in the injured area of the infarcted myocardium represents a challenge for regenerative medicine. Most cell-based grafts are unviable because of inadequate perfusion; therefore, prevascularization might be a suitable approach for myocardial tissue engineering. To this aim, cells with a differentiation potential towards vascular and cardiac muscle phenotypes have been cocultured in 2D or 3D appropriate scaffolds. In addition to these basic approaches, more sophisticated strategies have been followed employing mixed-cell sheets, mi
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Atlas, Yoann, Caroline Gorin, Anita Novais, et al. "Microvascular maturation by mesenchymal stem cells in vitro improves blood perfusion in implanted tissue constructs." Biomaterials 268 (January 2021): 120594. http://dx.doi.org/10.1016/j.biomaterials.2020.120594.

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Medhora, Meetha, John Daniels, Kavita Mundey, et al. "Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells." American Journal of Physiology-Heart and Circulatory Physiology 284, no. 1 (2003): H215—H224. http://dx.doi.org/10.1152/ajpheart.01118.2001.

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Angiogenesis is one of the most recent physiological functions attributed to products of cytochrome P-450 (CYP450) enymes. To test this at a molecular level in human cells, we used a cloned cDNA for the human endothelial enzyme CYP450 2C9 (CYP2C9) to study growth as well as differentiation of human microvascular endothelial cells from the lung (HMVEC-L). Using adenoviral vectors overexpressing mRNA for CYP2C9, we show that the presence of CYP2C9 doubles thymidine incorporation and stimulates proliferation of primary cultures of endothelial cells compared with Ad5-GFP (control) in 24 h. In addi
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Muehlich, Susanne, Iwona Cicha, Christoph D. Garlichs, Bettina Krueger, Guido Posern, and Margarete Goppelt-Struebe. "Actin-dependent regulation of connective tissue growth factor." American Journal of Physiology-Cell Physiology 292, no. 5 (2007): C1732—C1738. http://dx.doi.org/10.1152/ajpcell.00552.2006.

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Expression of connective tissue growth factor (CTGF) in endothelial cells is modulated by shear stress affecting the organization of the cytoskeleton. The molecular connection between alterations of actin and CTGF expression was investigated in human umbilical vein endothelial cells (HUVEC) and a microvascular endothelial cell line. Overexpression of nonpolymerizable monomeric actin R62D interfered with stress fiber formation in HUVEC and concomitantly reduced immunoreactive CTGF. In microvascular endothelial cells, flow-dependent upregulation of CTGF was prevented by this actin mutant. In con
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Dissertations / Theses on the topic "Microvascular constructs"

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Naik, Nisarga. "MEMS-based nozzles and templates for the fabrication of engineered tissue constructs." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/42853.

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This dissertation presents the application of MEMS-based approaches for the construction of engineered tissue substitutes. MEMS technology can offer the physical scale, resolution, and organization necessary for mimicking native tissue architecture. Micromachined nozzles and templates were explored for the fabrication of acellular, biomimetic collagenous fibrous scaffolds, microvascular tissue structures, and the combination of these structures with cell-based therapeutics. The influence of the microstructure of the tissue constructs on their macro-scale characteristics was investigated.
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Li, Mon Tzu. "Treatment strategy for composite tissue limb trauma." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54837.

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A majority of all fractures in current US armed conflicts are open fractures, in which a soft tissue injury is sustained along with the bone fracture. Even with gold standard treatment, in which muscle flaps are used to cover bony defects, patients often do not regain normal function of their extremity, highlighting the necessity for tissue engineering strategies for this complex clinical problem. Due to a substantial amount of tissue damage and debridement treatment in composite injuries, a large volume of cells and extracellular matrix (ECM) proteins that are necessary for tissue healing are
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Huang, Jen-Huang. "Novel Methods to Construct Microchannel Networks with Complex Topologies." Thesis, 2012. http://hdl.handle.net/1969.1/148269.

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Microfluidic technology is a useful tool to help answer unsolved problems in multidisciplinary fields, including molecular biology, clinical pathology and the pharmaceutical industry.Current microfluidic based devices with diverse structures have been constructed via extensively used soft lithography orphotolithography fabrication methods. A layer-by-layer stacking of 2D planar microchannel arrays can achieve limited degrees of three dimensionality. However, assembly of large-scale multi-tiered structures is tedious, and the inherently planar nature of the individual layers restricts the netwo
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Book chapters on the topic "Microvascular constructs"

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T., Mani, Stefanie V., and John W. "3-D Microvascular Tissue Constructs for Exploring Concurrent Temporal and Spatial Regulation of Postnatal Neovasculogenesis." In Research Directions in Tumor Angiogenesis. InTech, 2013. http://dx.doi.org/10.5772/53118.

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Conference papers on the topic "Microvascular constructs"

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Krishnan, Laxminarayanan, Carlos C. Chang, Shawn Reese, Stuart K. Williams, Jeffrey A. Weiss, and James B. Hoying. "Anchorage: Dependent Persistent Alignment of Perfused Microvasculature in Implanted Tissue Constructs." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53630.

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One of the challenges in engineering complex artificial tissue constructs, with defined matrix and cellular architecture, is the formation of a viable microcirculation within them, that inosculates with the host vasculature and matures into a functional microvascular bed. Current methods based on complex cell patterning in 2-D or 3-D matrix systems rely on ‘printing’ cells or patterns of cells on/ in a substrate, direct culture on patterned substrates, or endothelialization of decellularized vessels. We are now beginning to understand the effects of the microenvironment on microvascular constr
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Emerson, David R., and Robert W. Barber. "Designing Efficient Microvascular Networks Using Conventional Microfabrication Techniques." In ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18312.

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The ability to fabricate networks of micro-channels that obey the biological properties of bifurcating structures found in nature suggests that it is possible to construct artificial vasculatures or bronchial structures. These devices could aid in the desirable objective of eliminating many forms of animal testing. In addition, the ability to precisely control hydraulic conductance could allow designers to create specific concentration gradients that would allow biologists to correlate the behavior of cells. In 1926, Murray found that there was an optimum branching ratio between the diameters
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Zhou, Qinlian, Jian Gao, Wei Huang, and R. T. Yen. "Vascular Impedance Analysis in Human Pulmonary Circulation." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-33525.

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Vascular impedance in human pulmonary circulation is analyzed by the fluid dynamic approach. A model representing the entire system of pulmonary circulation is constructed based on experimentally measured morphometric and elasticity data of the vessels. The pulmonary arteries and veins are considered as elastic tubes. Their impedance follows Womersley’s theory and electric analogue. The “sheet-flow” theory is employed to describe the flow in capillaries and thus a microvascular impedance matrix is derived. The input impedance at the main pulmonary artery is calculated under both zone 3 and zon
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