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Journal articles on the topic 'Migraine pain'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Parrey, Mujeeb Ur Rehman, Maha M. Abdul-Latif, Muhammad Omer Afzal Bhatti, et al. "The link between migraine and eye pain: a review of current evidence." Anaesthesia, Pain & Intensive Care 29, no. 3 (2025): 681–88. https://doi.org/10.35975/apic.v29i3.2772.

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Eye pain is a frequent and distressing symptom in individuals with migraines, yet it remains an underexplored aspect of migraine pathology. This review consolidates current knowledge on the association between eye pain and migraines, covering pathophysiological mechanisms, clinical features, differential diagnoses, and management approaches. A thorough analysis of existing literature indicates that migraine-related eye pain is multifactorial, involving neural, vascular, and sensory pathways. Additionally, this review underscores the need for further research to refine diagnostic criteria and e

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Kalisiak, Jakub, Max Tschuschke, Martyna Choinka, et al. "Lignocaine in Migraine Treatment: A Comprehensive Review." Quality in Sport 23 (September 29, 2024): 55066. http://dx.doi.org/10.12775/qs.2024.23.55066.

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Introduction: Migraine is a prevalent and debilitating neurological disorder characterized by recurrent headaches and associated symptoms such as nausea, photophobia, and phonophobia. While conventional treatments exist, a significant subset of patients suffers from refractory migraines, prompting the exploration of alternative therapies like lignocaine. Purpose of the work: This review examines the mechanisms by which lignocaine modulatespain and underscores the potential of lignocaine as a therapeutic option for refractory migraines, while also highlighting the need for continued research to

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Muralinath, E., Devi Pooja, Chbukdhara Prasanta, et al. "The Impact of Drugs on Migraine: A Comprehensive Analysis." Journal of Mental health, Psychiatric and Psychosocial Nursing 2, no. 1 (2023): 1–4. https://doi.org/10.5281/zenodo.10389781.

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<em>MIGRAINE, a neurological disorder, manifested by severe headaches, frequently accompanied by nausea, sensitivity to light and sounds, influences millions of people worldwide. A very few drugs decrease the frequency and severity vof MIGRAINE attacks. Beta blockers are also helpful in decreasing migraine by controlling blood vessel constriction. Anti-depressants like amitryptalline are more useful to manage migraines because of their impact on serotonin levels, a neurotransmitter related to the migraine development. Anti-seizure drugs namely topiramate and valproate decrease migraine frequen

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Björner Brauer, Hanna, Karl Ryberg, Kjell Wallin, Mattias Linde, Thorbjörn Laike, and Bodil S. A. Karlsson. "Pain Relieving Light – (How) Is it Possible?" IOP Conference Series: Earth and Environmental Science 1320, no. 1 (2024): 012020. http://dx.doi.org/10.1088/1755-1315/1320/1/012020.

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Abstract About 15% of the population suffer from migraines and it is estimated that about 40% of all people with migraines would benefit from preventive treatment, but only 3–13% use it. Migraine is a huge burden for society and individuals. Migraines can be intensified by light, and some patients need to stay in a dark room until the attack is over. People with this type of photosensitivity show a clear preference for light color, specifically green, which has been shown to be more comfortable and even pain relieving in some cases. We will present a feasibility study with the aim of preparing

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de Tommaso, Marina, Vittorio Sciruicchio, Katia Ricci, et al. "Laser-evoked potential habituation and central sensitization symptoms in childhood migraine." Cephalalgia 36, no. 5 (2015): 463–73. http://dx.doi.org/10.1177/0333102415597527.

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Objectives Few studies have addressed central sensitization symptoms and pain processing in childhood migraine. Our aims were to examine pain sensitivity and responses, including habituation, evoked by CO2 laser stimuli (laser-evoked potentials (LEPs)) in a cohort of children with migraine compared to non-migraine controls and to determine the correlation between LEP features and signs of central sensitization. Methods Thirty-five patients 8–15 years of age with migraines without aura were evaluated during the inter-critical phase and were compared to 17 controls. LEPs were analyzed, and their

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Schwedt, Todd J., Melissa J. Krauss, Karen Frey, and Robert W. Gereau. "Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks." Cephalalgia 31, no. 1 (2010): 6–12. http://dx.doi.org/10.1177/0333102410365108.

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Objective: To determine if migraineurs have evidence of interictal cutaneous sensitisation. Subjects and methods: Thermal and mechanical pain thresholds in 20 episodic migraineurs, 20 chronic migraineurs, and 20 non-migraine control subjects were compared. Quantitative sensory testing was conducted when subjects had been migraine-free for at least 48 h. Heat, cold and mechanical pain thresholds, and heat and cold pain tolerance thresholds were measured. Results: Thermal pain thresholds and thermal pain tolerance thresholds differed significantly by headache group ( P = 0.001). During the inter

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Williams, Amy E., Megan M. Miller, Emily J. Bartley, Klanci M. McCabe, Kara L. Kerr, and Jamie L. Rhudy. "Impairment of Inhibition of Trigeminal Nociception via Conditioned Pain Modulation in Persons with Migraine Headaches." Pain Medicine 20, no. 8 (2019): 1600–1610. http://dx.doi.org/10.1093/pm/pny305.

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Abstract Objective To assess conditioned pain modulation efficiency in persons with and without migraine headaches. Design Cross-sectional assessment of experimental pain. Setting University campus and surrounding community in a large Midwestern US city. Subjects Twenty-three adults with and 32 without a history of migraine headaches participated in the study. Participants were mostly female (N = 40) with an average age of 23 years. Methods Four electrocutaneous stimulations of the supraorbital branch of the left trigeminal nerve were delivered at 150% of an individually determined pain thresh

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Cigarán-Mendez, Margarita, Juan C. Pacho-Hernández, Francisco G. Fernández-Palacios, et al. "Can Clinical, Psychophysical or Psychological Variables Help in Discriminating Women with Migraines from a Tertiary Center? A Diagnostic Accuracy Study." Diagnostics 14, no. 24 (2024): 2805. https://doi.org/10.3390/diagnostics14242805.

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Background: Migraine diagnosis is mainly clinically based on symptomatology. The objectives of this study were (1) to determine the ability of pain thresholds to differentiate between women with and without migraines and (2) to determine the ability of clinical, psychological and psychophysical variables to differentiate between women with episodic and chronic migraines. A diagnostic accuracy study was conducted. Methods: Pressure-pain thresholds (PPTs) at one trigeminal (temporalis muscle) and one extra-trigeminal (cervical spine) and two distant-pain free (second metacarpal and tibialis ante

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Simic, Svetlana, Petar Slankamenac, Milan Cvijanovic, Sofija Banic-Horvat, Zita Jovin, and Miroslav Ilin. "Menstrual migraine." Medical review 60, no. 9-10 (2007): 449–52. http://dx.doi.org/10.2298/mpns0710449s.

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Introduction. The prevalence of migraine in childhood and adolescence has not changed to a great extent, but it increases in adolescence, especially in female adolescents. Menstrual migraine ? definition. There are two types of menstrual migraine: true menstrual migraine and menstrual related migraine. True menstrual migraine occurs predominantly around menstruation, whereas menstrual related migraine occurs during menstruation, but also at other times during the month. Causes. Exaggerated or abnormal neurotransmitter responses to normal cyclic changes in the ovarian hormones are probably the

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Mainnah, Mut, Maya Septriana, and Wurlina Wurlina. "THE ROLE OF ACUPUNCTURE THERAPY TO OVERCOME ONE-SIDE HEAD PAIN (MIGRAINE)." Journal of Vocational Health Studies 5, no. 3 (2022): 192. http://dx.doi.org/10.20473/jvhs.v5.i3.2022.192-202.

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Background: Migraine is a primary headache, usually described as pain attacks lasting 4 - 72 hours, unilateral, throbbing, with moderate to severe pain intensity that can be exacerbated by activity, and can be accompanied by nausea and vomiting, photophobia and phonophobia. Migraine can interfere with patient activities, so that it can reduce productivity and result in an economic burden to the family and reduce the patient's quality of life. To handle it, pharmacological and non-pharmacological therapies can be used. Acupuncture therapy is one of the non-pharmacological therapeutic options th

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Briskey, David, Rachael Skinner, Chelsie Smith, and Amanda Rao. "Effectiveness of Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy Participants—A Double-Blind Randomised Controlled Study." Pharmaceuticals 17, no. 2 (2024): 145. http://dx.doi.org/10.3390/ph17020145.

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Migraines are a common neurological disorder that generally affects young to middle-aged adults and females more than males. Various treatment options are available; however, these can cause undesirable side effects. Therefore, alternative treatments with minimal side effects are still being investigated. Palmitoylethanolamide (PEA) is a signalling lipid known to have anti-inflammatory and analgesic properties. Previous prophylactic research has reported PEA supplementation to decrease pain associated with migraines. Upon commencement of migraine symptoms, participants were supplemented with e

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AZHAR, A., F. IRFAN, H. SHAKOOR, and IE KHUDA. "FREQUENCY OF MIGRAINE-RELATED DEPRESSION AMONG MIGRAINEURS IN PAKISTAN: A CROSS-SECTIONAL STUDY." Biological and Clinical Sciences Research Journal 2024, no. 1 (2024): 1101. http://dx.doi.org/10.54112/bcsrj.v2024i1.1101.

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Depressive disorders are among the leading causes of disability globally and can further complicate the clinical manifestation if coupled with other comorbidities. Objective: The main objective of the study is to find the frequency of migraine-related depression among migraineurs in Pakistan. Methods: This cross-sectional study was conducted at Fauji Foundation Hospital Rawalpindi from January 2024 to June 2024. Data were collected from 240 patients. Data were collected through a designed questionnaire which contain all data related to depression and awareness of patients. All the data related

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Chaliha, Devahuti Rai, Mauro Vaccarezza, Ryu Takechi, et al. "A Paradoxical Vasodilatory Nutraceutical Intervention for Prevention and Attenuation of Migraine—A Hypothetical Review." Nutrients 12, no. 8 (2020): 2487. http://dx.doi.org/10.3390/nu12082487.

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Studies suggest that migraine pain has a vascular component. The prevailing dogma is that peripheral vasoconstriction activates baroreceptors in central, large arteries. Dilatation of central vessels stimulates nociceptors and induces cortical spreading depression. Studies investigating nitric oxide (NO) donors support the indicated hypothesis that pain is amplified when acutely administered. In this review, we provide an alternate hypothesis which, if substantiated, may provide therapeutic opportunities for attenuating migraine frequency and severity. We suggest that in migraines, heightened

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Bach, Linda Lu, and Joshana Goga. "Management of migraine headaches in a chronic pain patient: A case report." Mental Health Clinician 6, no. 3 (2016): 154–58. http://dx.doi.org/10.9740/mhc.2016.05.154.

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Abstract Managing migraines complicated with medication overuse headaches and opioid-induced hyperalgesia can be challenging, especially within the geriatric and chronic pain population. A 65-year-old woman with a degenerative spine condition and chronic migraine headaches, along with other comorbidities, was admitted to the geriatric psychiatry unit for extreme mood swings and paranoia. Prior to admission, she had been taking extended-release morphine sulfate twice daily for more than a month and was unable to determine triggers to her frequent migraine headaches. She had a history of medicat

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McGeoch, Catherine, Rebecca S. Steinberg, Siya Thadani, and Alexis C. Cutchins. "35 Total-body symptom assessment in patients with idiopathic orthostatic intolerance to improve symptomatic management." Journal of Clinical and Translational Science 8, s1 (2024): 10–11. http://dx.doi.org/10.1017/cts.2024.52.

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OBJECTIVES/GOALS: Total-body symptom surveys among patients with idiopathic orthostatic intolerance (OI) at our referral center suggest that non-conventional OI symptoms, such as pelvic pain, impact quality of life. We seek to identify additional common yet unconventional symptoms reported during clinic visits to improve targeted symptom management. METHODS/STUDY POPULATION: Pelvic pain symptom surveys were completed by 178 patients age 18 and over with a chief complaint of OI. Pelvic pain prevalence was assessed using the International Pelvic Pain Society (IPPS) and Pelvic Congestion Syndrome

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Gharibi, Sholeh, and Abbas Sadeghi. "Alexithymia and Self-Efficacy With Pain Perception in Women with Migraines: A Cross-sectional Study." Caspian Journal of Health Research 6, no. 4 (2021): 121–28. http://dx.doi.org/10.32598/cjhr.6.4.383.1.

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Background: Pain perception in individuals with migraine is very important and is influenced by various factors. The aim of this study was to investigate the role of alexithymia and self-efficacy with pain perception in women with migraine. Materials & Methods: This cross-sectional study was performed in women with migraine referred to medical centers in Rasht in 2021. Using convenience sampling method, 160 women with migraines participated in the study and answered the demographic information questionnaire, Toronto Alexithymia Scale (TAS-20), General Self-Efficacy Scale (GSE) and McGill P

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Djuraev, Jamolbek A., Shokhimardon Kh Khodjanov, Nazim A. Akhundjanov, et al. "MIGRAINE: BASIC PRINCIPLES OF TREATMENT AND PREVENTION." International Journal of Medical Sciences And Clinical Research 03, no. 02 (2023): 88–91. http://dx.doi.org/10.37547/ijmscr/volume03issue02-17.

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Migraine is a disease manifested by attacks of severe headaches. Often, the pain is one-sided, pulsating, increases with physical exertion and may be accompanied by nausea and hypersensitivity to light, sound and smells. The precursors of migraines last from a few minutes to an hour. During this period, a person's balance, sensitivity, coordination of movements, speech and vision may be disturbed. Migraines usually begin during puberty and weaken after 50 years. Tension migraine is an incorrect term that is sometimes used to refer to tension headaches. Tension headaches are associated with str

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Fitria, Adinda S1* Rusli Dhanu2 &. Fasihah Irfani Fitri2. "ASSOCIATION BETWEEN SMOKING WITH MIGRAINE ATTACKS FREQUENCY AND PAIN INTENSITY IN CHRONIC MIGRAINE PATIENTS." INTERNATIONAL JOURNAL OF RESEARCH SCIENCE & MANAGEMENT 6, no. 4 (2019): 22–25. https://doi.org/10.5281/zenodo.2656421.

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<strong>Background:</strong> Smoking is a risk factor for chronic pain. Smoker patients with chronic pain also have more severe pain intensity. The relationship between migraines and smoking is still controversial. This study aims to determine the relationship of smoking to the frequency of attacks and pain intensity in chronic migraine patients. <strong>Method:</strong> This study used a cross-sectional design, in chronic migraine outpatient in Adam Malik General Hospital Medan, Indonesia. The diagnosis is based on anamnesis according to the Classification of International Headache Society 2<

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Buture, Alina, Jason W. Boland, Lisa Dikomitis, Chao Huang, and Fayyaz Ahmed. "Development and Evaluation of a Screening Tool to Aid the Diagnosis of Cluster Headache." Brain Sciences 10, no. 2 (2020): 77. http://dx.doi.org/10.3390/brainsci10020077.

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Cluster headache (CH), a severe primary headache, is often misdiagnosed and mismanaged. The aim of this study was to develop and evaluate a screening tool to aid the diagnosis of CH. We developed a novel 12-item screening tool. This was comprised of four components: (1) images depicting headache pain; (2) pain descriptors; (3) key questions that could differentiate between CH and migraine; and (4) a visual analogue pain scale. The total possible questionnaire score ranged from 3-32. Patients with CH and migraines (control group) were recruited prospectively from a headache centre in the North

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Shen, Yue, Zeguang Li, Jing Wang, and Zitong Qiu. "Study on the comprehensive treatment of migraine with traditional Chinese medicine based on the new pathophysiological mechanism: A review." Medicine 103, no. 35 (2024): e39487. http://dx.doi.org/10.1097/md.0000000000039487.

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Migraine is a ubiquitous neurological disorder that affects approximately 1 billion people worldwide. Migraine is the second leading cause of illness in people of all ages worldwide. Uncertainty in migraine diagnosis leads to unnecessary testing and increases the treatment costs. To date, the pathogenesis of migraine is not fully understood, but it is generally believed that migraine involves the trigeminal nerve and its axonal projections to intracranial blood vessels. Pain signals from the trigeminal neurovascular system are transmitted to the brain, resulting in migraines. As an important c

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Rajalekshmi K, Dhanya Dharman, Deepa Manohar, Shaiju S Dharan, Dhanya S S, and Bismi S. "A survey on functioning of male and female with migraine." International Journal of Research in Hospital and Clinical Pharmacy 1, no. 3 (2019): 85–87. http://dx.doi.org/10.33974/ijrhcp.v1i3.127.

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Migraines are severe, recurring, and painful headaches. The extreme pain have that migraines cause can last for hours or even days. Migraines can follow an aura of sensory disturbances followed by a severe headache that often appears on one side of the head. Objective of the study include; To find out whether male and female are more prone to develop migraine, To evaluate which triggering factors contributes to migraine and To evaluate the people taking OTC for migraine. A Prospective survey will be carried out in 75 peoples using the information’s gathered from students in Pharmacy colleges i

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Dehghani, Anisa, and Hulya Karatas. "Mouse Models of Familial Hemiplegic Migraine for Studying Migraine Pathophysiology." Current Neuropharmacology 17, no. 10 (2019): 961–73. http://dx.doi.org/10.2174/1570159x17666190513085013.

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Migraine, an extremely disabling neurological disorder, has a strong genetic component. Since monogenic migraines (resulting from mutations or changes in a single gene) may help researchers discover migraine pathophysiology, transgenic mice models harboring gene mutations identified in Familial Hemiplegic Migraine (FHM) patients have been generated. Studies in these FHM mutant mice models have shed light on the mechanisms of migraine and may aid in the identification of novel targets for treatment. More specifically, the studies shed light on how gene mutations, hormones, and other factors imp

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Golovacheva, Veronika A., and Anzhelika A. Golovacheva. "Treatment of chronic migraine and neck pain with cognitive-behavioral therapy. Case report." Consilium Medicum 23, no. 11 (2021): 852–57. http://dx.doi.org/10.26442/20751753.2021.11.201137.

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The article presents a case of a patient with chronic migraine, neck pain, drug-induced headache and generalized anxiety disorder. We analyzed the relationship between migraines and neck pain. The article discusses the interdisciplinary treatment of chronic migraine, which included educational conversation, detoxification therapy, rational relief of migraine attacks, preventive pharmacotherapy and cognitive-behavioral therapy. The latter allowed to change the patient's perception of the disease, reduce anxiety and catastrophization of pain, cope with fears, stop taking benzodiazepines, reduce

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Khan, Adnan, Sufang Liu, and Feng Tao. "Mechanisms Underlying Sex Differences in Temporomandibular Disorders and Their Comorbidity with Migraine." Brain Sciences 14, no. 7 (2024): 707. http://dx.doi.org/10.3390/brainsci14070707.

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Sexual dimorphism in temporomandibular disorders (TMDs) and their comorbidity with migraine are important phenomena observed in clinics. TMDs are the most prevalent orofacial pain conditions with jaw joint and masseter muscle dysfunction. Migraine is the predominant headache commonly associated with TMDs. Women much more often suffer from this orofacial pain than men. However, currently, there is no gender-specific therapy for such pain conditions. Understanding the pathophysiological mechanisms behind sex differences in TMDs as well as their comorbidity with migraines is essential for develop

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Vicente, Beatriz Nunes, Renato Oliveira, Isabel Pavão Martins, and Raquel Gil-Gouveia. "Cranial Autonomic Symptoms and Neck Pain in Differential Diagnosis of Migraine." Diagnostics 13, no. 4 (2023): 590. http://dx.doi.org/10.3390/diagnostics13040590.

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Cranial autonomic symptoms and neck pain have been reported to be highly prevalent in migraine, although they are rarely considered in clinical evaluation. The aim of this review is to focus on the prevalence, pathophysiology, and clinical characteristics of these two symptoms, and their importance in the differential diagnosis between migraines and other headaches. The most common cranial autonomic symptoms are aural fullness, lacrimation, facial/forehead sweating, and conjunctival injection. Migraineurs experiencing cranial autonomic symptoms are more likely to have more severe, frequent, an

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Setiawati, Octa Reni, Akhmad Kheru Dharmawan, Woro Pramesti, and Ani Oktasari. "Hubungan Stres Dengan Kejadian Migrain Pada Mahasiswa Fakultas Kedokteran Universitas Malahayati Di Saat Pandemi Covid-19." MAHESA : Malahayati Health Student Journal 2, no. 2 (2022): 390–400. http://dx.doi.org/10.33024/mahesa.v2i2.4520.

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ABSTRACT Stress is a general pattern of reactions and adaptations, in the sense that the pattern of reactions to stressors, which can come from within or outside the individual concerned, can be real or not. Headaches called migraines are headaches with pain attacks lasting 4 – 72 hours. Pain is usually unilateral, throbbing, moderate to severe pain intensity and exacerbated by activity, and may be accompanied by nausea and vomiting, photophobia and phonophobia. Complaints that are quite frequent and disturbing from among these complaints are migraine complaints. Migraines can interfere with a

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Setiawati, Octa Reni, Akhmad Kheru Dharmawan, Woro Pramesti, and Ani Oktasari. "Hubungan Stres Dengan Kejadian Migrain Pada Mahasiswa Fakultas Kedokteran Universitas Malahayati Di Saat Pandemi Covid-19." MAHESA : Malahayati Health Student Journal 2, no. 2 (2022): 390–400. http://dx.doi.org/10.33024/mahesa.v2i2.4520.

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ABSTRACT Stress is a general pattern of reactions and adaptations, in the sense that the pattern of reactions to stressors, which can come from within or outside the individual concerned, can be real or not. Headaches called migraines are headaches with pain attacks lasting 4 – 72 hours. Pain is usually unilateral, throbbing, moderate to severe pain intensity and exacerbated by activity, and may be accompanied by nausea and vomiting, photophobia and phonophobia. Complaints that are quite frequent and disturbing from among these complaints are migraine complaints. Migraines can interfere with a

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Borkowska, Agata, Anna Kiełb, Anna Mich, et al. "The use of triptans as an effective form of migraine treatment – review." Quality in Sport 37 (January 11, 2025): 56600. https://doi.org/10.12775/qs.2025.37.56600.

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Introduction Migraine, a prevalent neurological disorder, is characterized by recurrent episodes of moderate to severe headache, often accompanied by symptoms such as nausea, photophobia, and phonophobia. Triptans, which belong to the class of serotonin 5-HT1B/1D receptor agonists, are integral to the management of migraine, providing prompt relief from symptoms. Aim of the study To clarify how effective triptans are in treating migraines, highlighting their role in symptom relief and improving patients' quality of life Materials and methods The article is the result of a comprehensive analysi

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Shaterian, Negar, Negin Shaterian, Aref Ghanaatpisheh, et al. "Botox (OnabotulinumtoxinA) for Treatment of Migraine Symptoms: A Systematic Review." Pain Research and Management 2022 (March 31, 2022): 1–15. http://dx.doi.org/10.1155/2022/3284446.

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Background. Migraine is one of the most common types of headache, and it is the second most common cause of neurological disorders, with an annual prevalence of about 15% of the population. This study aimed to evaluate the effect of BoNT-A on the duration and intensity of migraine attacks. In addition, we investigated the effective injection sites. Methods. According to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines, we searched online databases, including Web of Science, PubMed, EMBASE, Scopus, Cochrane Library, ProQuest, ClinicalTrials.gov, and Goog

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Sciruicchio, Vittorio, Daniela D’Agnano, Livio Clemente, Alessandra Rutigliano, Anna Laporta, and Marina de Tommaso. "Clinical Correlates of Osmophobia in Primary Headaches: An Observational Study in Child Cohorts." Journal of Clinical Medicine 12, no. 8 (2023): 2939. http://dx.doi.org/10.3390/jcm12082939.

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Primary headaches, especially migraines, have a significant impact on physical and mental health, as well as on the scholarly performance and quality of life of children and adolescents. Osmophobia could be a potential diagnostic marker of migraine diagnosis and disability. This multicenter observational cross-sectional study included 645 children, aged 8–15, with a diagnosis of primary headaches. We took into consideration the duration, intensity and frequency of headaches, pericranial tenderness, allodynia and osmophobia. In a subgroup of migraine children, we evaluated the migraine-related

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Russo, Antonio, Alessandro Tessitore, Alfonso Giordano, Fabrizio Salemi, and Gioacchino Tedeschi. "The pain in migraine beyond the pain of migraine." Neurological Sciences 33, S1 (2012): 103–6. http://dx.doi.org/10.1007/s10072-012-1052-7.

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Hargreaves, RJ, and SL Shepheard. "Pathophysiology of Migraine — New Insights." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 26, no. 3 (1999): 12–19. http://dx.doi.org/10.1017/s0317167100000147.

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Current theories propose that the primary dysfunction in migraine occurs within the CNS and that this evokes changes in blood vessels within pain-producing intracranial meningeal structures that give rise to headache pain. Migraine is now thought of as a neurovascular disorder. It has been proposed that genetic abnormalities may be responsible for altering the response threshold to migraine specific trigger factors in the brain of a migraineur compared to a normal individual. The exact nature of the central dysfunction that is produced in migraineurs is still not clear and may involve spreadin

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Krishna Radhakrishna Pillai, Gowtham, Lakshmy Vinodkumar Nair, Umurzakova Gavkharoi Islamovna, Momunova AygulAbdykerimovna, Zubairov Zhoomart, and Murzalieva Aizhan Maratbekovna. "MIGRAINE AWARENESS AND MANAGEMENT AMONG MEDICAL STUDENTS AT OSH STATE MEDICAL UNIVERSITY." International Journal of Advanced Research 12, no. 12 (2024): 809–13. https://doi.org/10.21474/ijar01/20082.

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Migraine headaches significantly impact quality of life, particularly among young adults. This study aimed to assess the prevalence, severity, and management strategies of migraines among medical students at Osh State Medical University,INTERNATIONAL MEDICAL FACULTY (OSMU-IMF).Asurvey was conducted among OSMU,IMF medical students to collect data on demographic characteristics, migraine frequency, severity, triggers, impact, and management strategies. The results revealed a substantial prevalence of migraines among the study population. The majority of students reported moderate to severe migra

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Raieli, V., D. Raimondo, R. Cammalleri, and R. Camarda. "Migraine Headaches in Adolescents: A Student Population-Based Study in Monreale." Cephalalgia 15, no. 1 (1995): 5–12. http://dx.doi.org/10.1046/j.1468-2982.1995.1501005.x.

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We assessed the prevalence of migraine headaches in an epidemiological survey of an 11 to 14-year-old student population. Migraine headaches were classified on the basis of questionnaires and neurological examination using the operational diagnostic criteria of the International Headache Society. Prevalence of migraine without aura (IHS code 1.1) was 2.35%; that of migraine with aura (IHS code 1.2) was 0.62%. Migraine without aura was equally distributed among males and females, whereas migraine with aura was preponderant in the female cohort. The prevalence of migraine headaches in males was

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Madhuri, Chavan Pratiksha Chavan Sahil Chavan Swamini Dighe*. "Formulation and Evaluation of Herbal-Based Prophylactic Migraine Pain Relief Balm." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3658–70. https://doi.org/10.5281/zenodo.15483724.

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Migraine headaches are a widespread neurological issue, affecting millions of people worldwide, and are known for causing severe, disabling pain that can greatly reduce one’s quality of life. Although conventional medications may offer some relief, they are frequently associated with adverse side effects and potential long-term health concerns. This study aims to create a natural, non-invasive balm specifically designed to relieve migraine pain. The balm incorporates lavender oil and chamomile oil, both of which are well-known for their calming and anti-inflammatory properties. Eucalyptu

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Penhollow, Tina M., and Alexandra C. Mielke. "Aromatherapy: an alternative treatment for migraine headaches." International Physical Medicine & Rehabilitation Journal 9, no. 1 (2024): 1–4. http://dx.doi.org/10.15406/ipmrj.2024.09.00365.

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Neurological disorders are recognized as one of the leading causes of death and disability worldwide. Migraines are a neurological disorder that is often accompanied by symptoms such as pain, light and sound sensitivity, nausea, vomiting, and changes in vision. There are many challenges to managing episodic and chronic migraines. There are several non-modifiable and modifiable risk factors associated with migraine onset. Pharmacological management has been shown to be effective. Research has also shown that aromatherapy can have a positive impact on preventing and managing migraine headaches.

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Mattsson, P., and L. Ekselius. "Migraine, Major Depression, Panic Disorder, and Personality Traits in Women Aged 40-74 Years: A Population-Based Study." Cephalalgia 22, no. 7 (2002): 543–51. http://dx.doi.org/10.1046/j.1468-2982.2002.00407.x.

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This study investigates the associations between migraine on the one hand and lifetime major depression, lifetime panic disorder, and neuroticism evaluated using the Swedish universities Scales of Personality on the other. A neurologist clinically assessed 728 women aged 40-74 years attending a population-based mammography screening programme. The associations between lifetime migraine and personality traits and psychiatric disorders were insignificant in multivariable analysis. However, in old women (60-74 years) the risk for active migraine was strongly associated with a history of major dep

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Parvathy G.M, Ansha Akbar, Jabir S, Arya P.V, Amina Shajahan, and Fidha Sidheek. "COMBINED EFFECT OF AEROBIC EXERCISE AND PROGRESSIVE RELAXATION TRAINING IN PATIENTS WITH MIGRAINE." INTERNATIONAL JOURNAL OF MEDICAL AND EXERCISE SCIENCE 10, no. 04 (2024): 1974–85. https://doi.org/10.36678/ijmaes.2024.v10i04.005.

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Background of the study: Migraine is a neurological condition which is characterized by recurrent headaches and neurological symptoms which are lasting for 04 – 72 hrs., with unilateral location and pulsating quality2 . 01 out of 04 people in India have been seen to be suffering from migraine. Patients often request no pharmacological alternatives for the resolution of migraine3 . Recent advances have shown that exercise and relaxation training affect migraine. But lack of combined exercise is more effective brought about the background of the study. The objective of this study is to determine

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Yoon, M.-S., D. Mueller, N. Hansen, et al. "Prevalence of Facial Pain in Migraine: A Population-Based Study." Cephalalgia 30, no. 1 (2009): 92–96. http://dx.doi.org/10.1111/j.1468-2982.2009.01899.x.

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Unilateral head pain focused on frontal, orbital or parietal regions is a leading symptom of migraine attacks. Rarely, head pain in migraine can extend involving the maxillary or mandibular region of the face, sometimes isolated facial pain is the only and atypical presentation of migraine. The prevalence of these unusual symptoms in migraine is unknown. We aimed to estimate the true prevalence of facial pain in migraine in a population-based sample of 517 migraine patients in Germany. In 46 (8.9%) cases migraine pain involved the head and the lower half of the face. Patients with facial pain

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Adeney, KL, JL Flores, JC Perez, SE Sanchez, and MA Williams. "Prevalence and Correlates of Migraine Among Women Attending a Prenatal Care Clinic in Lima, Peru." Cephalalgia 26, no. 9 (2006): 1089–96. http://dx.doi.org/10.1111/j.1468-2982.2006.01171.x.

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Migraine headaches are among the leading causes of disability in the world. The burden of migraines is highest in women of reproductive age. This cross-sectional study characterized the prevalence, symptoms and correlates of migrainous headaches in 154 pregnant women attending a prenatal care clinic in Lima, Peru. Lifetime prevalence of migraine defined by modified IHS criteria was 9.1± (95± CI 4.6–13.6). When probable migraines were included, the lifetime prevalence of migraine in this population was 29.2± (95± CI 22.0–36.4). Migraine headaches were associated with a maternal history of heada

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Bigal, ME, CA Bordini, SJ Tepper, and JG Speciali. "Intravenous Magnesium Sulphate in the Acute Treatment of Migraine Without Aura and Migraine with Aura. A Randomized, Double-Blind, Placebo-Controlled Study." Cephalalgia 22, no. 5 (2002): 345–53. http://dx.doi.org/10.1046/j.1468-2982.2002.00364.x.

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Magnesium sulphate has been used in the acute treatment of migraines; some studies found it to be a highly effective medication in the acute control of migraine pain and associated symptoms. This randomized, double-blind, placebo-controlled study assesses the effect of magnesium sulphate on the pain and associated symptoms in patients with migraine without aura and migraine with aura. Sixty patients in each group were assigned at random to receive magnesium sulphate, 1000 mg intravenously, or 0.9% physiological saline, 10 ml. We used seven parameters of analgesic evaluation and an analogue sca

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Dai, Lingling, Qiang Xu, Xing Xiong, et al. "Propagation Structure of Intrinsic Brain Activity in Migraine without Aura." Brain Sciences 12, no. 7 (2022): 903. http://dx.doi.org/10.3390/brainsci12070903.

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Previous studies have revealed highly reproducible patterns of temporally lagged brain activity in healthy human adults. However, it is unknown whether temporal organization of intrinsic activity is altered in migraines or if it relates to migraine chronification. In this resting-state functional magnetic resonance imaging study, temporal features of intrinsic activity were investigated using resting-state lag analysis, and 39 episodic migraine patients, 17 chronic migraine patients, and 35 healthy controls were assessed. Temporally earlier intrinsic activity in the hippocampal complex was rev

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Barchakh, Zahra, Zahra Mardani Valandani, and Fariborz Khorvash. "The Effectiveness of Compassion-focused Therapy for Improving Emotional Control and Reducing the Severity of Pain in Migraine Patients." Practice in Clinical Psychology 9, no. 1 (2021): 51–60. http://dx.doi.org/10.32598/jpcp.9.1.740.1.

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Objective: Because of the unwanted effects of the patient’s migraine headaches and the role of excitement and stress in the development and exacerbation of headaches, migraine headaches are psychosomatic disorders that affect the patients’ psychological lives. The present study aimed to investigate the effectiveness of Compassion-Focused Therapy (CFT) for improving emotional control and reducing the severity of pain in patients with migraines. Methods: A total of 30 patients with migraines referred to Isfahan Al-Zahra Hospital, Isfahan City, Iran, were selected and randomly divided into experi

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Hvedstrup, Jeppe, Lærke Tørring Kolding, Samaira Younis, Messoud Ashina, and Henrik Winther Schytz. "Ictal neck pain investigated in the interictal state – a search for the origin of pain." Cephalalgia 40, no. 6 (2019): 614–24. http://dx.doi.org/10.1177/0333102419896369.

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Background Neck pain is reported in more than 50% of migraine patients during migraine attacks and may be an important source to migraine pain. Objectives To investigate phenotypical differences between migraine patients with and without ictal neck pain in the interictal phase. Additionally, to prospectively examine the association between pericranial muscle tenderness and the impending migraine attack. Methods Migraine patients (n = 100) and controls (n = 46) underwent a semi-structured interview and sensory testing interictally. Pericranial muscle tenderness was determined using total tender

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Agarwal, Anjali, Suraj Kumar, and Gowrishankar Potturi. "Effectiveness of endonasal cranial balloon release technique in relieving symptoms of migraine and improving the quality of work in a sedentary worker - A single case study." Journal of medical pharmaceutical and allied sciences 11, no. 2 (2022): 4539–41. http://dx.doi.org/10.55522/jmpas.v11i2.2224.

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Migraine is a neurological condition affecting women more than man is often a cause to decrease the quality of work and productivity in workers. This study introduces a novel technique Endonasal Cranial balloon release, which has potential benefits in the treatment of migraine and its symptoms. This is a single case report of 37-year-old female who presented with a 2-year history of migraine with no other comorbidities and having difficulty in participating actively in the work-place. After explaining the entire procedure and written consent, the patient was treated with Endonasal Cranial ball

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Herranz-Gómez, Aida, Irene García-Pascual, Pablo Montero-Iniesta, Roy La Touche, and Alba Paris-Alemany. "Effectiveness of Exercise and Manual Therapy as Treatment for Patients with Migraine, Tension-Type Headache or Cervicogenic Headache: An Umbrella and Mapping Review with Meta-Meta-Analysis." Applied Sciences 11, no. 15 (2021): 6856. http://dx.doi.org/10.3390/app11156856.

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The aim of the study was to perform a mapping and umbrella review with meta-meta-analysis (MMA) to synthesise and critically evaluate the effectiveness of manual therapy (MT) and aerobic exercise (AE) in relation to pain intensity, frequency, disability and quality of life in patients with migraines, tension-type headaches (TTH) and cervicogenic headaches (CGH). A systematic search was conducted in PubMed, PEDro, Scielo and Google Scholar up to December 2020. A total of 18 articles met the inclusion criteria, and only 8 were included in the quantitative analysis. The MMA showed results in favo

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Im, Hee-Jin, Yoo-Ha Hong, and Soo-Jin Cho. "Neck Pain Disability on Headache Impact and the Association between Sleep Disturbance and Neck Pain in Migraine." Journal of Clinical Medicine 12, no. 12 (2023): 3989. http://dx.doi.org/10.3390/jcm12123989.

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Neck pain (NP) is a prevalent symptom among migraine patients, but its disability on headache impact and the contributing factors for comorbid NP are poorly understood. This study aimed to investigate NP disability on the impact of headaches among migraineurs and factors linked to comorbid NP, including sleep-related variables. This cross-sectional study was conducted at a university hospital headache center, for headache patients at their first visits. Included in the study were 295 patients with migraines (217 females; 39.0 ± 10.8 years; 101 chronic migraine). Information on NP, history of p

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Dacka, Michał, Mateusz Sobczyk, Paulina Dąbrowska, Kamila Giżewska, and Michał Żuber. "Role of calcitonin gene-related peptide (CGRP) receptor antagonist in acute and preventive treatment of migraine." Prospects in Pharmaceutical Sciences 22, no. 3 (2024): 21–26. http://dx.doi.org/10.56782/pps.206.

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Migraine is the most common neurological disease in the world. It is characterized by recurrent attacks of severe headaches of a one-sided, throbbing nature, often accompanied by sensory and motor disturbances and generally associated with nausea and increased sensitivity to light and sound. Migraine treatment can be divided into emergency treatment and preventive treatment, which aims to reduce the overall frequency and severity of attacks. In the first case, nonsteroidal anti-inflammatory drugs (NSAIDs) can be used, but in some patients they do not have the desired effect. The gold standard

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Spekker, Eleonóra, Gábor Nagy-Grócz, and László Vécsei. "Ion Channel Disturbances in Migraine Headache: Exploring the Potential Role of the Kynurenine System in the Context of the Trigeminovascular System." International Journal of Molecular Sciences 24, no. 23 (2023): 16574. http://dx.doi.org/10.3390/ijms242316574.

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Migraine is a primary headache disorder, which is an enormous burden to the healthcare system. While some aspects of the pathomechanism of migraines remain unknown, the most accepted theory is that activation and sensitization of the trigeminovascular system are essential during migraine attacks. In recent decades, it has been suggested that ion channels may be important participants in the pathogenesis of migraine. Numerous ion channels are expressed in the peripheral and central nervous systems, including the trigeminovascular system, affecting neuron excitability, synaptic energy homeostasi

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ÖZŞİMŞEK, Ahmet, Burak YULUG, Ece Özdemir ÖKTEM, Şeyda ÇANKAYA, and Umut DURAN. "THE IMPACT OF COVID-19 INFECTION AND TREATMENT ON MIGRAINE DISABILITY AND PAIN SCORES." INTERNATIONAL REFEREED ACADEMIC JOURNAL OF SPORTS, no. 44 (2022): 0. http://dx.doi.org/10.17363/sstb.2022/abcd89/.44.3.

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Aim: This study aimed to investigate the effects of favipravir used for treating Covid-19 infection and other infectious diseases, on migraine severity and frequency through VAS (Visual Analog Scale), MIDAS (Migraine Disability Assesment Scale). Methods: The study was planned retrospectively, from January 2020 to September 2021, to evaluate patient demographical features who have received migraine diagnosis before or after Covid-19 infection (3 months) admitted in the neurology outpatient clinics of Alanya Alaaddin Keykubat University Training and Research Hospital. Findings: From 70 patients

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