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Journal articles on the topic 'Migraine with photophobia'

Author: Grafiati

Published: 7 June 2025

Last updated: 16 July 2025

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1

Vanagaite, J., JA Pareja, O. St⊘ren, LR White, T. Sanc, and LJ Stovner. "Light-Induced Discomfort and Pain in Migraine." Cephalalgia 17, no. 7 (1997): 733–41. http://dx.doi.org/10.1046/j.1468-2982.1997.1707733.x.

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Quantitative thresholds for discomfort and pain with monocular and binocular light stimuli were measured in 67 controls and 67 migraine patients 37 migraine with aura and 30 migraine without aura). Patients were more photophobic during attack than outside attack ( p<0.03), and they were more sensitive to light than controls even between attacks ( p0001). We found no differences in light sensitivity between migraine with aura and migraine without aura ( p0.93). Unilateral pain affected light sensitivity on both sides. When asked with a questionnaire, 74% of patients answered that they were s

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Maheshkumar, Rajpura. "Compare Pupil Size in Migraine Patients with Photophobia versus Normal Subjects and Correlation of the Pupil Size to Severity of Headache." International Journal of Pharmaceutical and Clinical Research 16, no. 10 (2024): 235–38. https://doi.org/10.5281/zenodo.14032657.

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This study suggests that patients with migraines and photophobia have significantly larger pupil sizes compared to normal subjects without headaches. The findings indicate a correlation between pupil size and the severity of migraine disability as measured by the Migraine Disability Assessment (MIDAS) test.  Migraine patients with photophobia had a mean pupil size of 4.89 mm, while normal subjects had a mean of 3.8 mm. The difference was statistically significant. Based on MIDAS grades, patients with more severe disability (Grade 4) had the largest pupil size, averaging 5.6 mm. This indic

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Nagata, Eiichiro, Motoharu Takao, Haruki Toriumi, et al. "Hypersensitivity of Intrinsically Photosensitive Retinal Ganglion Cells in Migraine Induces Cortical Spreading Depression." International Journal of Molecular Sciences 25, no. 14 (2024): 7980. http://dx.doi.org/10.3390/ijms25147980.

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Migraine is a complex disorder characterized by episodes of moderate-to-severe, often unilateral headaches and generally accompanied by nausea, vomiting, and increased sensitivity to light (photophobia), sound (phonophobia), and smell (hyperosmia). Photophobia is considered the most bothersome symptom of migraine attacks. Although the underlying mechanism remains unclear, the intrinsically photosensitive retinal ganglion cells (ipRGCs) are considered to be involved in photophobia associated with migraine. In this study, we investigated the association between the sensitivity of ipRGCs and migr

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Choi, J.-Y., K. Oh, B.-J. Kim, C.-S. Chung, S.-B. Koh, and K.-W. Park. "Usefulness of a Photophobia Questionnaire in Patients With Migraine." Cephalalgia 29, no. 9 (2009): 953–59. http://dx.doi.org/10.1111/j.1468-2982.2008.01822.x.

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Photophobia is an important criterion for the diagnosis of migraine. However, several Asian epidemiological surveys about migraine have shown lesser prevalence of photophobia than that of Western studies. This discrepancy is probably caused by underestimation of photophobia due to inappropriate questioning of patients by physicians. To investigate this issue, we developed a questionnaire about photophobia and evaluated its usefulness in 103 patients with migraine. In phase 1 of the study, we found good repeatability of the questionnaire with a 0.826 k coefficient. In phase 2, the prevalence of

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Villar-Martinez, María Dolores, and Peter J. Goadsby. "Dim the Lights: A Narrative Review of Photophobia in Migraine." Neurology 18, no. 1 (2022): 14. http://dx.doi.org/10.17925/usn.2022.18.1.14.

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A preference for darkness is one of the main associated features in people with migraine, the cause remaining a mystery until some decades ago. In this article, we describe the epidemiology of photophobia in migraine and explain the pathophysiological mechanisms following an anatomical structure. In addition, we review the current management of migraine and photophobia. Ongoing characterization of patients with photophobia and its different manifestations continues to increase our understanding of the intricate pathophysiology of migraine and vice versa. Detailed phenotyping of the patient wit

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Pinheiro, Carina F., Jessica R. Moreira, Gabriela F. Carvalho, Leticia Zorzin, Fabiola Dach, and Debora Bevilaqua-Grossi. "Interictal Photophobia and Phonophobia Are Related to the Presence of Aura and High Frequency of Attacks in Patients with Migraine." Applied Sciences 11, no. 6 (2021): 2474. http://dx.doi.org/10.3390/app11062474.

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Background: Despite that photophobia and phonophobia are well-known symptoms related to migraine, it is unclear whether they affect daily life activities during the headache-free period. Objective: To evaluate the interictal photophobia/phonophobia intensity during daily activities in migraineurs and non-headache individuals. Methods: Women with migraine without aura (MoA, n = 30), migraine with aura (MA, n = 30), chronic migraine (CM, n = 30) and without headache (CG, n = 30) reported the photophobia and phonophobia intensity during daily activities using a Likert scale ranging from 0 (no dis

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Molina, Omar Franklin, Zeila Coelho Santos, Laura Martins, et al. "Differentiating occipital neuralgia from migraine and tension-type headache." Revista Neurociências 22, no. 3 (2014): 425–31. http://dx.doi.org/10.34024/rnc.2014.v22.8071.

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Objective. To establish differential diagnosis in patients presenting occipital neuralgia, tension-type headache, and migraine with aura. Method. We analyzed 32 patients with Occipital neuralgia (mean age=38.0; females=75%), 102 with tension-type headache (mean age=33.0; females=92.2%), and 16 with migraine without aura (mean age=37.0; females=56.3%). The specific symptoms of headaches were used in according to International Classification of Headache Disorders (ICHD) in patients with for craniomandibular disorders and bruxing behavior. Results. Occipital neuralgia group presented more nausea

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Eren, Ozan E., Ruth Ruscheweyh, Andreas Straube, and Christoph J. Schankin. "Quantification of photophobia in visual snow syndrome: A case-control study." Cephalalgia 40, no. 4 (2019): 393–98. http://dx.doi.org/10.1177/0333102419896780.

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Objective To quantify photophobia in visual snow syndrome (VSS), a debilitating migraine-associated visual disturbance manifesting with continuous “TV snow-like” flickering dots in the entire visual field and additional visual symptoms, such as photophobia. Methods Photophobia was compared between 19 patients with VSS and 19 controls matched for age, sex, migraine and aura using the Leiden Visual Sensitivity Scale (L-VISS). Results Patients with VSS had an increased L-VISS-score compared to matched controls [(22.2 ± 5.9 vs. 4.4 ± 4.8; ANOVA, factors VSS and comorbid migraine: Main effect for V

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Kitagawa, Satoshi, Chunhua Tang, Miyuki Unekawa, Yohei Kayama, Jin Nakahara, and Mamoru Shibata. "Sustained Effects of CGRP Blockade on Cortical Spreading Depolarization-Induced Alterations in Facial Heat Pain Threshold, Light Aversiveness, and Locomotive Activity in the Light Environment." International Journal of Molecular Sciences 23, no. 22 (2022): 13807. http://dx.doi.org/10.3390/ijms232213807.

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A migraine is clinically characterized by repeated headache attacks that entail considerable disability. Many patients with migraines experience postdrome, the symptoms of which include tiredness and photophobia. Calcitonin gene-related peptide (GGRP) is critically implicated in migraine pathogenesis. Cortical spreading depolarization (CSD), the biological correlate of migraine aura, sensitizes the trigeminovascular system. In our previous study, CSD caused hypomotility in the light zone and tendency for photophobia at 72 h, at which time trigeminal sensitization had disappeared. We proposed t

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Borkowska, Agata, Anna Kiełb, Anna Mich, et al. "The use of triptans as an effective form of migraine treatment – review." Quality in Sport 37 (January 11, 2025): 56600. https://doi.org/10.12775/qs.2025.37.56600.

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Introduction Migraine, a prevalent neurological disorder, is characterized by recurrent episodes of moderate to severe headache, often accompanied by symptoms such as nausea, photophobia, and phonophobia. Triptans, which belong to the class of serotonin 5-HT1B/1D receptor agonists, are integral to the management of migraine, providing prompt relief from symptoms. Aim of the study To clarify how effective triptans are in treating migraines, highlighting their role in symptom relief and improving patients' quality of life Materials and methods The article is the result of a comprehensive analysi

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Harshitha, V. and Dr. V. Kusum Devi*. "CHALLENGES IN BRAIN DELIVERY OF ANTI-MIGRAINE DRUGS AND CURRENT INITIATIVES TO IMPROVE THERAPEUTIC OUTCOMES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 03 (2019): 4809–19. https://doi.org/10.5281/zenodo.2587036.

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<em>Migraine is a common headache which is usually associated with nausea, photophobia and impaired daily activities. However, migraine can be extremely disabling with a considerable impact on the life of an individual in their ability to work. The arrival of triptans in the early 1990s saw a major change in the way migraines were treated, and triptans remain the gold standard in treating an acute attack. In recent times, considerable research has been made in understanding the pathophysiology of migraine. Numerous drug delivery systems have been discovered as therapies for brain disorders whi

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Irimia, P., E. Cittadini, K. Paemeleire, AS Cohen, and PJ Goadsby. "Unilateral Photophobia or Phonophobia in Migraine Compared With Trigeminal Autonomic Cephalalgias." Cephalalgia 28, no. 6 (2008): 626–30. http://dx.doi.org/10.1111/j.1468-2982.2008.01565.x.

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Our objective was to compare the presence of self-reported unilateral photophobia or phonophobia, or both, during headache attacks comparing patients with trigeminal autonomic cephalalgias (TACs)—including cluster headache, shortlasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and paroxysmal hemicrania—or hemicrania continua, and other headache types. We conducted a prospective study in patients attending a referral out-patient clinic over 5 months and those admitted for an intramuscular indomethacin test. Two hundred and six patients were includ

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Silva, Greice Cardoso de Carvalho, Cristiana Pessoa de Queiroz Faria Góes, and Maurice Borges Vincent. "Aura-like features and photophobia in sightless migraine patients." Arquivos de Neuro-Psiquiatria 72, no. 12 (2014): 949–53. http://dx.doi.org/10.1590/0004-282x20140200.

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Migraine is a central nervous system disorder frequently expressed with paroxysmal visual dysfunctions. Objective To test the hypothesis that normal visual input is vital for the migrainous aura and photophobia. Method We studied the migraine-related visual disturbances in 8 sightless migraineurs identified among 200 visually impaired subjects. Results The main findings were the visual aura and photophobia disappearance along with blindness development, the oddness of aura – too short, colourful (e.g. blue or fire-like), auditory in nature or different in shape (round forms) – and the lack of

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Diel, Ryan J., Jodi Hwang, Zachary A. Kroeger, et al. "Photophobia and sensations of dryness in patients with migraine occur independent of baseline tear volume and improve following botulinum toxin A injections." British Journal of Ophthalmology 103, no. 8 (2018): 1024–29. http://dx.doi.org/10.1136/bjophthalmol-2018-312649.

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BackgroundTo evaluate the efficacy of botulinum toxin A (BoNT-A) in reducing photophobia and dry eye symptoms in individuals with chronic migraine. Additionally, we aimed to evaluate tear film volume as a potential contributor to symptoms in these patients.MethodsRetrospective review of 76 patients who received BoNT-A for chronic migraine between 23 August 2017 and 13 December 2017 at the Miami Veterans Affairs Medical Center Neurotoxin Clinic. Demographic data and all comorbidities were queried via chart review. Standardised validated surveys were administered to assess symptoms prior to and

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Younis, Samaira, Anders Hougaard, Rodrigo Noseda, and Messoud Ashina. "Current understanding of thalamic structure and function in migraine." Cephalalgia 39, no. 13 (2018): 1675–82. http://dx.doi.org/10.1177/0333102418791595.

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Objective To review and discuss the literature on the role of thalamic structure and function in migraine. Discussion The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal functional connectivity between the thalamus and various cortical regions pointing towards an altered pain processing in migraine. Pharmacological nociceptive modulation suggests that the thalamus is a potential drug target. Conclusion A critical role for the thalamus in migraine-related allodynia and

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Ciuba, Katarzyna, Barbara Borodziuk, Filip Borodziuk, et al. "Caffeine and migraine – friends or enemies?" Quality in Sport 18 (July 25, 2024): 53225. http://dx.doi.org/10.12775/qs.2024.18.53225.

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Severe headaches or migraines are a common neurological disorder that can significantly affect people's daily lives and is serious problem for individuals and society. A migraine is intense headache lasting 4-72 hours, typically localized on one side of the head and accompanied by nausea, sensitivity to light (phonophobia), sound (photophobia), and smell (osmophobia). The pathophysiology of migraines is complex and involves neurovascular and biochemicals mechanisms. Understanding the mechanisms that trigger the transition from a headache-free state to the headache phase is important to underst

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Shibata, Koichi, Kiyomi Yamane, Kuniaki Otuka, and Makoto Iwata. "Neurophysiological characteristics of photophobia in migraine." Autonomic Neuroscience 135, no. 1-2 (2007): 106–7. http://dx.doi.org/10.1016/j.autneu.2007.06.180.

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Bigal, ME, CA Bordini, SJ Tepper, and JG Speciali. "Intravenous Magnesium Sulphate in the Acute Treatment of Migraine Without Aura and Migraine with Aura. A Randomized, Double-Blind, Placebo-Controlled Study." Cephalalgia 22, no. 5 (2002): 345–53. http://dx.doi.org/10.1046/j.1468-2982.2002.00364.x.

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Magnesium sulphate has been used in the acute treatment of migraines; some studies found it to be a highly effective medication in the acute control of migraine pain and associated symptoms. This randomized, double-blind, placebo-controlled study assesses the effect of magnesium sulphate on the pain and associated symptoms in patients with migraine without aura and migraine with aura. Sixty patients in each group were assigned at random to receive magnesium sulphate, 1000 mg intravenously, or 0.9% physiological saline, 10 ml. We used seven parameters of analgesic evaluation and an analogue sca

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Cortez, Melissa M., Natalie A. Rea, Lindsay A. Hunter, Kathleen B. Digre, and KC Brennan. "Altered pupillary light response scales with disease severity in migrainous photophobia." Cephalalgia 37, no. 8 (2017): 801–11. http://dx.doi.org/10.1177/0333102416673205.

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Background Autonomic dysfunction and light sensitivity are core features of the migraine attack. Growing evidence also suggests changes in these parameters between attacks. Though sensory and autonomic responses likely interact, they have not been studied together across the spectrum of disease in migraine. Methods We performed digital infrared pupillometry while collecting interictal photophobia thresholds (PPT) in 36 migraineurs (14 episodic; 12 chronic; 10 probable) and 24 age and sex-matched non-headache controls. Quantitative pupillary light reflexes (PLR) were assessed in a subset of sub

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Drummond, PD. "Tryptophan Depletion Increases Nausea, Headache and Photophobia in Migraine Sufferers." Cephalalgia 26, no. 10 (2006): 1225–33. http://dx.doi.org/10.1111/j.1468-2982.2006.01212.x.

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Sensitivity to light was investigated 5 and 8 h after consumption of an amino acid drink which contained L-tryptophan (balanced amino acid condition: 19 controls and 22 migraine sufferers) or which produced a short-term reduction in brain serotonin synthesis by omitting L-tryptophan (tryptophan depletion condition: 16 controls and 16 migraine sufferers). Migraine sufferers reported more intense nausea, headache, glare- and light-induced pain than controls. In addition, glare- and light-induced pain were greater in the tryptophan depletion condition than in the balanced amino acid condition, in

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Vitali-Silva, Aline, Valéria Aparecida Bello, Regina Célia Poli-Frederico, et al. "Relationship between food triggers and sensory hypersensitivity in patients with migraine." Arquivos de Neuro-Psiquiatria 82, no. 11 (2024): 001–7. https://doi.org/10.1055/s-0044-1793934.

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Abstract Background The recognition of food as the trigger of attacks occurs in approximately 25% of individuals with migraine. However, differentiating migraine food triggers and prodrome symptoms is still a challenge. Objective To understand the association of clinical characteristics of migraine with food triggers and to identify predictors of food triggers. Methods Patients with migraine diagnosed according to the criteria of the third edition of the International Classification of Headache Disorders (ICHD-3) were evaluated for the presence or absence of food triggers. Results In total, 50

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Kalisiak, Jakub, Max Tschuschke, Martyna Choinka, et al. "Lignocaine in Migraine Treatment: A Comprehensive Review." Quality in Sport 23 (September 29, 2024): 55066. http://dx.doi.org/10.12775/qs.2024.23.55066.

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Introduction: Migraine is a prevalent and debilitating neurological disorder characterized by recurrent headaches and associated symptoms such as nausea, photophobia, and phonophobia. While conventional treatments exist, a significant subset of patients suffers from refractory migraines, prompting the exploration of alternative therapies like lignocaine. Purpose of the work: This review examines the mechanisms by which lignocaine modulatespain and underscores the potential of lignocaine as a therapeutic option for refractory migraines, while also highlighting the need for continued research to

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Drummond, Peter D., and Anne Woodhouse. "Painful Stimulation of the Forehead Increases Photophobia in Migraine Sufferers." Cephalalgia 13, no. 5 (1993): 321–24. http://dx.doi.org/10.1046/j.1468-2982.1993.1305321.x.

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Thresholds for visual and auditory discomfort were investigated in 51 migraine sufferers and 27 controls of similar age and sex distribution who rarely suffered from headache. Tests in migraine sufferers were carried out during the headache-free interval. Discomfort thresholds were measured before and during painful stimulation of the forehead with ice. The visual discomfort threshold was lower in migraine sufferers than in controls, and decreased further during painful stimulation of the forehead. In contrast, the auditory discomfort threshold was similar in migraine sufferers and controls, a

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Kim, Seung Jae, Hye Jeong Lee, Sue Hyun Lee, Soomi Cho, Kyung Min Kim, and Min Kyung Chu. "Most bothersome symptom in migraine and probable migraine: A population-based study." PLOS ONE 18, no. 11 (2023): e0289729. http://dx.doi.org/10.1371/journal.pone.0289729.

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Recently, the most bothersome symptom has been recommended as a co-primary endpoint in clinical trials on the acute treatment of migraine. Probable migraine is a subtype of migraine that fulfills all but one criterion for migraine diagnosis. We aimed to compare the most bothersome symptom between probable migraine and migraine. This study analyzed data from a nationwide study conducted in Korea, and the most bothersome symptom was assessed by requesting the participants to select one of the four typical accompanying symptoms of migraine. Responses to acute treatment were evaluated using the mi

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Kelman, L. "The Place of Osmophobia and Taste Abnormalities in Migraine Classification: A Tertiary Care Study of 1237 Patients." Cephalalgia 24, no. 11 (2004): 940–46. http://dx.doi.org/10.1111/j.1468-2982.2004.00766.x.

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This study evaluates osmophobia and taste abnormalities in relationship to sensitivity and specificity in the classification of migraine. Consecutive International Headache Society (IHS) classified patients ( n = 1237) were evaluated. Symptoms were graded from 0 to 3. Osmophobia and taste abnormalities were tested for sensitivity and specificity in migraine diagnosis. The patients were 85.4% female and their mean age was 38.1 years. Of 673 patients 24.7% complained of osmophobia, and 24.6% of 505 complained of taste abnormalities. In the absence of nausea and vomiting the combinations of two s

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Thakurdesai, Prasad Arvind, Pooja Abhay Bhalerao, and Urmila Manoj Aswar. "Intranasal Administration of Standardized Extract of Gotu Kola Leaves Against Nitroglycerine-Induced Recurrent Migraine-Like Pain in Rats." Biomedical and Pharmacology Journal 17, no. 3 (2024): 1445–59. http://dx.doi.org/10.13005/bpj/2955.

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The present study aimed to determine the efficacy of intranasal administration of a standardized extract of Gotu kola, i.e., Centella asiatica (L.) Urban (INDCA-NS) with marker triterpenoids for the prevention of nitroglycerine- (NTG)-induced recurrent migraine in rats. Adult rats of both sexes in a group of 12 were administered intraperitoneal NTG (10 mg/kg) on alternate days (D1 to D9) and once daily intranasal solutions of either vehicle (saline, 50 µL/rat/day), sumatriptan (80 µL/rat/day of 12 mg/ml) as positive control, or INDCA-NS (10, 30, or 100 µg/rat/day) for 21 days. Behavioral and b

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Drummond, PD. "Motion Sickness and Migraine: Optokinetic Stimulation Increases Scalp Tenderness, Pain Sensitivity in the Fingers and Photophobia." Cephalalgia 22, no. 2 (2002): 117–24. http://dx.doi.org/10.1046/j.1468-2982.2002.00332.x.

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The aim of this study was to determine whether scalp tenderness and photophobia, two well-recognized symptoms of migraine, develop during the motion sickness induced by optokinetic stimulation. To investigate whether motion sickness has a general influence on pain perception, pain was also assessed in the fingertips. After optokinetic stimulation, nausea increased more and headache persisted longer in 21 migraine sufferers than in 15 non-headache controls. Scalp tenderness increased during optokinetic stimulation in nauseated subjects, and pain in the fingertips increased more and photophobia

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Kluser, Stephanie, Andrew Chan, and Niklaus Meier. "When “unclear headache” has an obvious reason—Applying ID-Migraine™ to referral letters." Cephalalgia Reports 2 (January 1, 2019): 251581631986620. http://dx.doi.org/10.1177/2515816319866207.

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Background: Migraine is underdiagnosed especially by general practitioners and non-neurologists. In our experience, validated screening and diagnosing tools for migraine are generally not used outside neurology. The three-item identification of migraine (ID-Migraine™) is a short and validated screening/diagnosing tool; positive predictive value for migraine is 93% if at least two out of nausea, photophobia, or disability are present. Aim: To investigate the diagnostic yield of ID-Migraine™ when applied to the information provided in the referral letters. Methods: Retrospective analysis of 95 r

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McAdams, Harrison, Eric A. Kaiser, Aleksandra Igdalova, et al. "Selective amplification of ipRGC signals accounts for interictal photophobia in migraine." Proceedings of the National Academy of Sciences 117, no. 29 (2020): 17320–29. http://dx.doi.org/10.1073/pnas.2007402117.

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Second only to headache, photophobia is the most debilitating symptom reported by people with migraine. While the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs) are thought to play a role, how cone and melanopsin signals are integrated in this pathway to produce visual discomfort is poorly understood. We studied 60 people: 20 without headache and 20 each with interictal photophobia from migraine with or without visual aura. Participants viewed pulses of spectral change that selectively targeted melanopsin, the cones, or both and rated the degree of visual di

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Brandes, Jan Lewis, David Kudrow, Paul P. Yeung, et al. "Effects of fremanezumab on the use of acute headache medication and associated symptoms of migraine in patients with episodic migraine." Cephalalgia 40, no. 5 (2019): 470–77. http://dx.doi.org/10.1177/0333102419885905.

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Background Fremanezumab, a fully humanized monoclonal antibody targeting calcitonin gene-related peptide, has demonstrated efficacy for the preventive treatment of migraine in adults. Objective To evaluate the effect of fremanezumab treatment on acute headache medication use and migraine-associated symptoms in patients with episodic migraine. Methods In the Phase 3 HALO trial, patients with episodic migraine were randomized to receive subcutaneous fremanezumab monthly (225 mg at baseline, weeks 4 and 8), fremanezumab quarterly (675 mg at baseline, placebo at weeks 4 and 8), or placebo over a 1

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Johnson, ES, DM Ratcliffe, and M. Wilkinson. "Naproxen Sodium in the Treatment of Migraine." Cephalalgia 5, no. 1 (1985): 5–10. http://dx.doi.org/10.1046/j.1468-2982.1985.0501005.x.

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Seventy patients with classical or common migraine were treated during their attacks with either naproxen sodium or placebo in a randomised, double-blind parallel group study. The initial dose of naproxen sodium was 825 mg followed one hour later by a further 550 mg, if symptoms were the same or had improved. If the migraine symptoms had worsened, patients were offered an escape analgesic combination of 1000 mg paracetamol and 10 mg metoclopramide. Patients were assessed at monthly intervals for changes in the severity and duration of headache, premonitory symptoms (mainly visual disturbances)

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Gherpelli, JLD, LM Nagae Poetscher, AMMH Souza, et al. "Migraine in Childhood and Adolescence. A Critical Study of the Diagnostic Criteria and of the Influence of Age on Clinical Findings." Cephalalgia 18, no. 6 (1998): 333–41. http://dx.doi.org/10.1046/j.1468-2982.1998.1806333.x.

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We studied 253 children aged <15 years. Phase 1 included 193 children with migraine (1.1 and 1.2) divided into two groups (<10 and ≥10 years). We studied the relationship between age and migraine type, headache characteristics, and associated symptoms of the International Headache Society (IHS) definition. A higher frequency of migraine with aura, pulsatile quality, and unilateral location was observed in older children. In phase 2 we studied 176 children with headache (excluding migraine with aura), comparing diagnostic criteria, definition items, sensitivity, and specificity. The resul

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Jones, Nick. "Mice shed light on photophobia and migraine." Nature Reviews Neurology 5, no. 9 (2009): 465. http://dx.doi.org/10.1038/nrneurol.2009.121.

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Olesen, Jes. "A neural pathway for photophobia in migraine." Nature Reviews Neurology 6, no. 5 (2010): 241–42. http://dx.doi.org/10.1038/nrneurol.2010.50.

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Holroyd, KA, JB Drew, CK Cottrell, KM Romanek, and V. Heh. "Impaired Functioning and Quality of Life in Severe Migraine: The Role of Catastrophizing and Associated Symptoms." Cephalalgia 27, no. 10 (2007): 1156–65. http://dx.doi.org/10.1111/j.1468-2982.2007.01420.x.

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Migraine characteristics are associated with impaired functioning and quality of life (Fn/QoL), but the impact of other factors on Fn/QoL in headache patients is largely unexplored. We examined catastrophizing, comorbid anxiety/depression and migraine characteristics as related to Fn/QoL, and explored the consistency of these relationships across five Fn/QoL measures. We evaluated 232 frequent migraine sufferers for comorbid psychiatric diagnosis, and they completed anxiety, depression and catastrophizing measures, recorded migraine characteristics in a diary and completed five Fn/QoL measures

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Mares, Christopher, Jehane H. Dagher, and Mona Harissi-Dagher. "Narrative Review of the Pathophysiology of Headaches and Photosensitivity in Mild Traumatic Brain Injury and Concussion." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 46, no. 1 (2018): 14–22. http://dx.doi.org/10.1017/cjn.2018.361.

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AbstractThe most common symptom of post-concussive syndrome (PCS) is post-traumatic headache (PTH) accompanied by photophobia. Post-traumatic headache is currently categorized as a secondary headache disorder with a clinical phenotype described by its main features and resembling one of the primary headache disorders: tension, migraine, migraine-like cluster. Although PTH is often treated with medication used for primary headache disorders, the underlying mechanism for PTH has yet to be elucidated. The goal of this narrative literature review is to determine the current level of knowledge of t

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Çam, Mustafa, and Sedat Arikan. "Evaluation of iris epithelial and stromal thickness in patients with migraine by using optical coherence tomography." Neurology Asia 27, no. 1 (2021): 153–60. http://dx.doi.org/10.54029/2022kpy.

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Objective: The amount of light reaching to the retina is an important factor for photophobia formation. Therefore, investigation of iris thickness in patients with migraine can be valuable for revealing their susceptibility to photophobia. In this study, it was aimed to evaluate the iris epithelial and stromal thickness, retinal ganglion cell layer (RGCL) thickness, and retinal nerve fibre layer (RNFL) thickness of patients with migraine. Methods: Forty-nine migraine patients (Group 1) and 50 control participants (Group 2) were included into this study. For obtaining standard measure in all pa

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Hosseini, Somaye, Reyhaneh Rikhtehgaran, Mohammad Saadatnia, Alireza Zandifar, and Marjan Mansourian. "Longitudinal Modeling of Non-Pharmacological Factors Related to Frequency, Severity and Duration in Both Migraine and Tension-Type Headaches." Journal of Research in Health Sciences 20, no. 4 (2020): e00495-e00495. http://dx.doi.org/10.34172/jrhs.2020.29.

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Background: Frequency, severity, and duration of attacks are some major parameters in headache management, affected by some other factors. Ignoring these factors in headache-related studies can lead to incorrect results. We aimed to model both socio-demographic characteristics and headache-associated symptoms related to frequency, severity and duration of headache attacks. Study design: A longitudinal panel study. Methods: Overall, 275 migraines or tension Type Headache (TTH) patients were visited at three different times in 2012 in Isfahan, Iran. On the first visit socio-demographic character

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Wilkins, A. "Fear of light: On the cause and remediation of photophobia." Lighting Research & Technology 53, no. 5 (2021): 395–404. http://dx.doi.org/10.1177/1477153521998415.

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Photophobia (fear of light) occurs in a wide range of ophthalmic, neurological and behavioural conditions, the most common of which is migraine. The visual discomfort associated with migraine can occur not only in response to bright light but also flicker, spatial pattern and colour. The principles that underlie the discomfort are explored and methods to reduce it are proposed.

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van Dongen, Robin M., and Joost Haan. "Symptoms related to the visual system in migraine." F1000Research 8 (July 30, 2019): 1219. http://dx.doi.org/10.12688/f1000research.18768.1.

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Migraine is a common headache disorder characterized by often-severe headaches that may be preceded or accompanied by a variety of visual symptoms. Although a typical migraine aura is not difficult to diagnose, patients with migraine may report several other visual symptoms, such as prolonged or otherwise atypical auras, “visual blurring”, “retinal migraine”, “ophthalmoplegic migraine”, photophobia, palinopsia, and “visual snow”. Here, we provide a short overview of these symptoms and what is known about the relationship with migraine pathophysiology. For some symptoms, the association with mi

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Hansen, Jakob M., Peter J. Goadsby, and Andrew C. Charles. "Variability of clinical features in attacks of migraine with aura." Cephalalgia 36, no. 3 (2015): 216–24. http://dx.doi.org/10.1177/0333102415584601.

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Background There is significant variability in the clinical presentation of migraine, both among patients, and between attacks in an individual patient. We examined clinical features of migraine with aura in a large group of patients enrolled in a clinical trial, and compared retrospective migraine attack characteristics reported upon enrollment in the trial with those recorded prospectively in the trial. Methods Patients with migraine ( n = 267) with typical visual aura in more than 30% of their attacks were enrolled from 16 centers for a clinical trial. Upon enrollment, patients provided a d

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Shibata, Yasushi. "Anti-Calcitonin Gene-Related Peptide Monoclonal Antibody Is Effective for Preventing Migraine Aura Without Headache." Neurology International 16, no. 6 (2024): 1279–84. http://dx.doi.org/10.3390/neurolint16060097.

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Background: Anti-calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) are clinically effective in preventing the migraine attacks, photophobia, and migraine auras associated with headaches. However, no study has yet investigated the effectiveness of CGRP mAbs in preventing migraine aura without headache. Case report: A female patient of 49 years old presented with a long history (since age 10) of photosensitivity and typical migraine auras without a headache. The symptoms slightly responded to oral medication, lomerizine chloride, but did not completely resolve. Just one day after

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Cha, Y.-H., H. Lee, LS Santell, and RW Baloh. "Association of Benign Recurrent Vertigo and Migraine in 208 Patients." Cephalalgia 29, no. 5 (2009): 550–55. http://dx.doi.org/10.1111/j.1468-2982.2008.01770.x.

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The aim of this study was to determine the association of benign recurrent vertigo (BRV) and migraine, using standardized questionnaire-based interview of 208 patients with BRV recruited through a University Neurotology clinic. Of 208 patients with BRV, 180 (87%) met the International Classification of Headache Disorders 2004 criteria for migraine: 112 migraine with aura (62%) and 68 without aura (38%). Twenty-eight (13%) did not meet criteria for migraine. Among patients with migraine, 70% experienced headache, one or more auras, photophobia, or auditory symptoms with some or all of their ver

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Ly, Quoc Y., Bich Loan Dang, Minh Thai Duong, To Tran Pham, and Van Minh Le. "STUDY OF CLINICAL CHARACTERISTICS AND SOME RISK FACTORS OF MIGRAINE HEADACHE AT CAN THO CENTRAL GENERAL HOSPITAL IN 2022-2023." Tạp chí Y Dược học Cần Thơ, no. 7 (May 16, 2024): 158–63. http://dx.doi.org/10.58490/ctump.2024i7.2974.

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Background: Migraine is a common disorder; however, it is still not perfectly diagnosed and treated due to many difficulties in recognizing symptoms or accompanying risk factors. Understanding migraine headaches through surveying standard samples can guide clinicians in the appropriate way of diagnosis and treatment. Objectives: The study aimed to describe the clinical characteristics of migraine and to investigate some risk factors related to migraine headaches among patients examined at Can Tho Central General Hospital during 2022-2023. Materials and methods: A cross-sectional descriptive st

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AL-Mahdawi, Akram M., Gheyath Al Gawwam, and Saad Hadi Al-ANI. "Old patient migraine in comparrision with younger adult migrain." Journal of the Faculty of Medicine Baghdad 57, no. 2 (2015): 109–13. http://dx.doi.org/10.32007/jfacmedbagdad.572336.

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Background: Migraine is a common chronic episodic disabling primary headache disorder. Migraine can affect all age groups elderly and young age with different presentation of symptoms between two age groups. The prevelance of migraine is highest between 20 and 55 years peaking at age around 40 years of age and the declines thereafter, however the primary headache disorder does also exist in older population.Objective: This study was undertaken in order to find out the differences in the characteristics of migraine headache between elderly and young for easy diagnosis and treatment.Patient and

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Noseda, Rodrigo, Carolyn A. Bernstein, Rony-Reuven Nir, et al. "Migraine photophobia originating in cone-driven retinal pathways." Brain 139, no. 7 (2016): 1971–86. http://dx.doi.org/10.1093/brain/aww119.

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Baldacci, F., C. Lucchesi, M. Ulivi, et al. "Photophobia is associated with allodynia during migraine attack." Journal of the Neurological Sciences 333 (October 2013): e487. http://dx.doi.org/10.1016/j.jns.2013.07.1726.

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Alshehri, Fahad S., Ahmed M. Ashour, Adnan S. Alharbi, Alqassem Y. Hakami, and Nasser M. Alorfi. "Understanding migraine in Saudi society: An assessment of public knowledge and attitudes: A cross-sectional study." PLOS ONE 19, no. 6 (2024): e0304840. http://dx.doi.org/10.1371/journal.pone.0304840.

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Objective This study aims to assess the knowledge and perceptions of the public toward migraine in Saudi Arabia. Methods This cross-sectional survey assessed the knowledge and perceptions of migraine among Saudi Arabian individuals. The study was conducted over three months in 2023 (1st of June 2023 to 31st of August 2023) using a prevalidated online questionnaire divided into four sections. Results A total of 1,975 adults aged between 18 and 64 completed the web-based survey. Of these, over half were male (n = 1,268; 64.2%). The main causes of migraine identified by the participants were gene

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Chronicle, EP, and WM Mulleners. "Visual System Dysfunction in Migraine." Cephalalgia 16, no. 8 (1996): 525–35. http://dx.doi.org/10.1046/j.1468-2982.1996.1608525.x.

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This paper reviews both clinical and experimental literature relating to visual dysfunction in migraine, starting with the eye and progressing via the retina and visual pathways to the visual cortex. Migraine is associated with (i) a pupillary sympathetic hypofunction, and (ii) a cortical hypersensitivity to visual stimuli (perhaps only in migraine with aura), the pathogenesis of which remains to be determined. Various hypotheses are discussed, and it is proposed that the methods of visual psychophysics may represent a useful approach in the future study of cortical hyperexcitability in migrai

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Magi, Dr Sujata, Dr Veerayya R Hiremath, Dr Shashikala D K, Dr Gururaj N, and Dr Raju S N. "MANAGEMENT OF ARDHAVABHEDAKA (MIGRAINE) WITH ANUTAILA NASYA: A CASE STUDY." Avishkara 01, no. 03 (2022): 15–19. http://dx.doi.org/10.56804/avishkara.2022.1305.

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Ardhvabhedaka (migraine without aura) is characterized by severe tearing, pricking and piercing pain in one half of the head and giddiness which develops suddenly after ten days or a fortnight. Based on signs and symptoms it may correlate with migraine characterized by half sided headache associated with nausea, vomiting, photophobia and Phonophobia. The current line of management for migraine advocates the use of analgesics and antiemetic’s, vasoconstrictors, sumatriptan, topiramate, flunarizine, Propranolol. Ayurveda emphasizes various treatment modalities of Ardhvabhedaka, includes both Sho

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