Academic literature on the topic 'Migratory Phenotype'

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Journal articles on the topic "Migratory Phenotype"

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Pujol-Castiblanque, A., T. Savin, A. E. Markaki, and R. Mair. "P01.01.A CHARACTERIZATION OF GLIOBLASTOMA’S MIGRATION HETEROGENEITY THROUGH A PATIENT-DERIVED 3D MODEL." Neuro-Oncology 26, Supplement_5 (2024): v30. http://dx.doi.org/10.1093/neuonc/noae144.089.

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Abstract BACKGROUND Glioblastoma (GB) is an aggressive brain cancer with an average survival of 14.6 months. Effective treatment is hindered by GB’s plasticity and invasive phenotype. Little is known regarding the molecular mechanisms driving invasion heterogeneity. MATERIAL AND METHODS We developed a bioengineered model of brain-like matrix, which together with patient-derived spheroids, allows study of GB’s migration in vitro. Twenty patient-derived cell lines with different intrinsic (genomic, transcriptomic) characteristics in several extrinsic (extracellular matrix stiffness, hypoxia vs n
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Jain Gupta, Neelu, and Vinod Kumar. "Testes play a role in termination but not in initiation of the spring migration in the night-migratory blackheaded bunting." Animal Biology 63, no. 3 (2013): 321–29. http://dx.doi.org/10.1163/15707563-00002415.

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Day length regulates the development of seasonal phenotypes linked with both the spring migration (e.g., premigratory body fattening and intense nighttime restlessness, called Zugunruhe, in captive birds) and reproduction (e.g., gonadal growth and maturation). The apparent overlap in these photoinduced seasonal phenotypes could be taken to suggest that they are causally linked. The present study investigates this, using the night-migratory blackheaded bunting (Emberiza melanocephala). We continuously monitored activity of male buntings exposed for 19 weeks to short (8 h light : 16 h darkness;
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Tanaka, Tatsuya, Rui Ueda, and Takuya Sato. "Captive-bred populations of a partially migratory salmonid fish are unlikely to maintain migratory polymorphism in natural habitats." Biology Letters 17, no. 1 (2021): 20200324. http://dx.doi.org/10.1098/rsbl.2020.0324.

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Variation in life history is fundamental to the long-term persistence of populations and species. Partial migration, in which both migratory and resident individuals are maintained in a population, is commonly found across animal taxa. However, human-induced habitat fragmentation continues to cause a rapid decline in the migratory phenotype in many natural populations. Using field and hatchery experiments, we demonstrated that despite both migrants and residents being maintained in captive environments, few individuals of the red-spotted masu salmon, Oncorhynchus masou ishikawae , became migra
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Martins, Soraia A., Patrícia D. Correia, Roberto A. Dias, Odete A. B. da Cruz e Silva, and Sandra I. Vieira. "CD81 Promotes a Migratory Phenotype in Neuronal-Like Cells." Microscopy and Microanalysis 25, no. 1 (2019): 229–35. http://dx.doi.org/10.1017/s1431927618015532.

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AbstractTetraspanins, such as CD81, can form lateral associations with each other and with other transmembrane proteins. These interactions may underlie CD81 functions in multiple cellular processes, such as adhesion, morphology, migration, and differentiation. Since CD81's role in neuronal cells’ migration has not been established, we here evaluated effects of CD81 on the migratory phenotype of SH-SY5Y neuroblastoma cells. CD81 was found enriched at SH-SY5Y cell's membrane, co-localizing with its interactor filamentous-actin (F-actin) in migratory relevant structures of the leading edge (filo
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Conroy, Christian W., Jay Calvert, Graham D. Sherwood, and Jonathan H. Grabowski. "Distinct responses of sympatric migrant and resident Atlantic cod phenotypes to substrate and temperature at a remote Gulf of Maine seamount." ICES Journal of Marine Science 75, no. 1 (2017): 122–34. http://dx.doi.org/10.1093/icesjms/fsx101.

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Abstract Life-history strategies often vary within motile marine species, affecting morphometry, growth, diet, and fecundity. Atlantic cod (Gadus morhua) in the Gulf of Maine display marked variation in a number of life-history traits, exemplified by differences in body colour. Migratory behaviours are suspected to differ among these colour types, but have yet to be shown definitively. Here, we used the combination of an acoustic telemetry system and fine-scale benthic habitat maps to reveal that the red phenotype cod adhered to an isolated kelp forest covering <2 km2 of a seamount in t
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Outlaw, Diana C., and V. Nijman. "Morphological evolution of some migratory Ficedula flycatchers." Contributions to Zoology 80, no. 4 (2011): 279–84. http://dx.doi.org/10.1163/18759866-08004005.

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Long-distance migration imposes physiological and morphological selection pressures on birds. The genus Ficedula, a lineage of Old World flycatchers, consists of long- and short-distance migratory species, as well as sedentary species. Members of each of these groups are not reciprocally monophyletic, yet each of the behavioral groups is morphologically distinguishable even when accounting for phylogeny. Long-distance migratory species have more pointed wings than either short-distance migratory or sedentary species, and migratory behaviors and wing pointed-ness are phylogenetically correlated
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Disanza, Andrea, Sara Bisi, Emanuela Frittoli, et al. "Is cell migration a selectable trait in the natural evolution of cancer development?" Philosophical Transactions of the Royal Society B: Biological Sciences 374, no. 1779 (2019): 20180224. http://dx.doi.org/10.1098/rstb.2018.0224.

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Selective evolutionary pressure shapes the processes and genes that enable cancer survival and expansion in a tumour-suppressive environment. A distinguishing lethal feature of malignant cancer is its dissemination and seeding of metastatic foci. A key requirement for this process is the acquisition of a migratory/invasive ability. However, how the migratory phenotype is selected for during the natural evolution of cancer and what advantage, if any, it might provide to the growing malignant cells remain open issues. In this opinion piece, we discuss three possible answers to these issues. We w
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Anwar, Adil, Min Li, Maria G. Frid, et al. "Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension." American Journal of Physiology-Lung Cellular and Molecular Physiology 303, no. 1 (2012): L1—L11. http://dx.doi.org/10.1152/ajplung.00050.2012.

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Increased cell proliferation and migration, of several cell types are key components of vascular remodeling observed in pulmonary hypertension (PH). Our previous data demonstrate that adventitial fibroblasts isolated from pulmonary arteries of chronically hypoxic hypertensive calves (termed PH-Fibs) exhibit a “constitutively activated” phenotype characterized by high proliferative and migratory potential. Osteopontin (OPN) has been shown to promote several cellular activities including growth and migration in cancer cells. We thus tested the hypothesis that elevated OPN expression confers the
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Rubtsova, Svetlana N., Irina Y. Zhitnyak, and Natalya A. Gloushankova. "Phenotypic Plasticity of Cancer Cells Based on Remodeling of the Actin Cytoskeleton and Adhesive Structures." International Journal of Molecular Sciences 22, no. 4 (2021): 1821. http://dx.doi.org/10.3390/ijms22041821.

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There is ample evidence that, instead of a binary switch, epithelial-mesenchymal transition (EMT) in cancer results in a flexible array of phenotypes, each one uniquely suited to a stage in the invasion-metastasis cascade. The phenotypic plasticity of epithelium-derived cancer cells gives them an edge in surviving and thriving in alien environments. This review describes in detail the actin cytoskeleton and E-cadherin-based adherens junction rearrangements that cancer cells need to implement in order to achieve the advantageous epithelial/mesenchymal phenotype and plasticity of migratory pheno
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Hsieh, Tze-chen, and Joseph M. Wu. "Resveratrol Suppresses Prostate Cancer Epithelial Cell Scatter/Invasion by Targeting Inhibition of Hepatocyte Growth Factor (HGF) Secretion by Prostate Stromal Cells and Upregulation of E-cadherin by Prostate Cancer Epithelial Cells." International Journal of Molecular Sciences 21, no. 5 (2020): 1760. http://dx.doi.org/10.3390/ijms21051760.

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Cancer mortality is primarily attributed to metastasis and the resulting compromise of organs secondary to the initial tumor site. Metastasis is a multi-step process in which the tumor cells must first acquire a migratory phenotype and invade through the surrounding tissue for spread to distant organs in the body. The ability of malignant cells to migrate and breach surrounding tissue/matrix barriers is among the most daunting challenges to disease management for men in the United States diagnosed with prostate cancer (CaP), especially since, at diagnosis, a high proportion of patients already
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Dissertations / Theses on the topic "Migratory Phenotype"

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Bradley, Conor Aidan. "c-MET as a key regulator of an invasive and migratory phenotype in colorectal cancer." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695258.

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In the current study, we initially investigated the molecular mechanisms driving tumour cell migration and invasion in vitro using in-house generated invasive CRC cell line models, with which we reported an association between HGF-independent overexpression and hyper-phosphorylation of c-MET with a mesenchymal, migratory and invasive phenotype. Upon identification of this association, we subsequently demonstrated that RNAi-mediated ablation of c-MET abolished the basal migratory and invasive potential of CRC cell lines, illustrating a key role for c- MET expression in regulation of these pheno
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Lugo, Ramos Juan Sebastian Verfasser], Miriam [Akademischer Betreuer] [Liedvogel, and von der Schulenburg Hinrich [Gutachter] Graf. "An integrative study of bird migration : From the migratory phenotype to its gene regulation mechanisms and back. / Juan Sebastian Lugo Ramos ; Gutachter: Hinrich Graf von der Schulenburg ; Betreuer: Miriam Liedvogel." Kiel : Universitätsbibliothek Kiel, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:8-mods-2020-00313-7.

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Lugo, Ramos Juan Sebastian [Verfasser], Miriam [Akademischer Betreuer] Liedvogel, and von der Schulenburg Hinrich [Gutachter] Graf. "An integrative study of bird migration : From the migratory phenotype to its gene regulation mechanisms and back. / Juan Sebastian Lugo Ramos ; Gutachter: Hinrich Graf von der Schulenburg ; Betreuer: Miriam Liedvogel." Kiel : Universitätsbibliothek Kiel, 2020. http://d-nb.info/1219904643/34.

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Tibblin, Petter. "Migratory behaviour and adaptive divergence in life-history traits of pike (Esox lucius)." Doctoral thesis, Linnéuniversitetet, Institutionen för biologi och miljö (BOM), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-42995.

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Population divergence shaped by natural selection is central to evolutionary ecology research and has been in focus since Darwin formulated “The origin of species”. Still, the process of adaptive divergence among sympatric populations is poorly understood. In this thesis I studied patterns of adaptive divergence among subpopulations of pike (Esox lucius) that are sympatric in the Baltic Sea but become short-term allopatric during spawning and initial juvenile growth in freshwater streams. I also examined causes and consequences of phenotypic variation among individuals within subpopulations to
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Noack, Patrick T. "Carotenoid pigments as phenotypic tracers of salmonid life histories : studies on eggs, alevins and juveniles of trout (Salmo trutta L.) and sea lice of Atlantic salmon (Salmo salar L.)." Thesis, University of Aberdeen, 1997. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU483277.

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The use of carotenoid pigments as an archive of feeding behaviour and thus as environmental markers was tested using eggs and juveniles of sea trout and brown trout (Salmo trutta L.) invertebrates from the River Don and ectoparasitic lice (Lepeophtheirus salmonis Kroyer) of Atlantic salmon (Salmo salar L.). Carotenoids were analysed by normal phase high performance liquid chromatography (HPLC) and the resulting peaks examined in multivariate analyses. Analysis of trout eggs of known parentage suggested that the pigment profile of each egg reflects the migratory history of the maternal fish and
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Pascoal, Flavia Sofia Rodrigues de Almeida. "CDC42 role in APP-mediated cell migration." Master's thesis, 2018. http://hdl.handle.net/10773/25078.

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Cellular migration is transversal to several cellular processes such as embryogenesis, metastasis, immune response and regeneration. The amyloid precursor protein and the Cdc42 protein have been separately associated with several processes related to cell migration, namely: velocity, cell adhesion, cell polarization, and the development of migratory structures such as filopodia and lamellipodia. In this work we intended to confirm the role of APP in persistent direction of migration of neuronal-like cells, previously observed in our group, and to investigate if APP interacted with Cdc42 in thi
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Books on the topic "Migratory Phenotype"

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Turner, Dorothea. The migratory behaviour of lotic macroinvertebrates, and the implications of genotypic and phenotypic variation in studies of their dispersal and response to environmental change. National Library of Canada, 1996.

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Book chapters on the topic "Migratory Phenotype"

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Swartz, Adam M., Kelly M. Hotchkiss, Smita K. Nair, John H. Sampson, and Kristen A. Batich. "Generation of Tumor Targeted Dendritic Vaccines with Improved Immunogenic and Migratory Phenotype." In Vaccine Design. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1884-4_33.

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Berends, R., M. Youseffi, and M. Denyer. "Transforming growth factor β 3 causes decreased HaCaT cell alignment to extracellular matrix proteins Fibronectin, Laminin and Collagen type I as a result of an enhanced migratory phenotype." In IFMBE Proceedings. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-03900-3_55.

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Ng, Aik Seng, Seow Theng Ong, Dermot Kelleher, and Navin Kumar Verma. "Quantification of T-Cell Migratory Phenotypes Using High-Content Analysis." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9036-8_4.

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Bhuvaneswari, Dr Mahalingam, Dr Sathish Muthukumar, and Dr Merlin Jayaraj. "EPITHELIAL MESENCHYMAL TRANSITION." In Emerging Trends in Oral Health Sciences and Dentistry. Technoarete Publishers, 2022. http://dx.doi.org/10.36647/etohsd/2022.01.b1.ch017.

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An epithelial-mesenchymal transition (EMT) is a biologic process that allows a polarized epithelial cell, which normally interacts with basement membrane via its basal surface, to undergo multiple biochemical changes that enable it to assume a mesenchymal cell phenotype, which includes enhanced migratory capacity, invasiveness, elevated resistance to apoptosis, and greatly increased production of ECM components”. EMT was classified into three types, based on its activity in the human body at varied events during: 1) Embryogenesis, 2) Physiological Wound healing and Fibrosis, 3) Cancer Progress
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Harre, Ulrike, and Georg Schett. "Mechanisms of bone and cartilage destruction." In Oxford Textbook of Rheumatoid Arthritis. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198831433.003.0009.

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Structural damage of cartilage and bone tissue is a hallmark of rheumatoid arthritis (RA). The resulting joint destruction constitutes one of the major disease consequences for patients and creates a significant burden for the society. The main cells executing bone and cartilage degradation are osteoclasts and fibroblast-like synoviocytes, respectively. The function of both cell types is influenced by the immune system. In past decades, research has identified several mediators of structural damage, ranging from infiltrating immune cells and inflammatory cytokines to autoantibodies. These fact
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Voisin, Charlotte, Ghislaine Cauchois, Danièle Bensoussan, and Céline Huselstein. "Effects of Cell Confluence on the Immunological and Migration Receptors of Wharton Jelly’s Mesenchymal Stem Cells." In Stem Cells and Regenerative Medicine. IOS Press, 2021. http://dx.doi.org/10.3233/bhr210029.

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Mesenchymal stem/stromal cells (MSCs) are a promising tool for cell-based therapy thanks to their ability to secrete trophic factors and immunomodulatory potential. So far, these cells are used to treat a variety of inflammatory diseases like sepsis or severe graft-versus-host disease (GvHD). Considering the number of cells required for their use in cell therapy (between 1–3 × 106 cells/kg), a primary expansion is necessary. However, after an intravenous injection, few cells are found in tissue lesion or in bone marrow. One hypothesis is that chemotactic signals that guide MSCs to an appropria
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"Challenges for Diadromous Fishes in a Dynamic Global Environment." In Challenges for Diadromous Fishes in a Dynamic Global Environment, edited by Bror Jonsson and Nina Jonsson. American Fisheries Society, 2009. http://dx.doi.org/10.47886/9781934874080.ch32.

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<em>Abstract</em>.-Populations of Atlantic salmon <em>Salmo salar </em>can be restored and enhanced through planting of green or eyed eggs (embryos) in rivers and by releasing fry, parr, smolts, or postsmolts. The success of the releases varies with time and site of release, broodstock origin, size and age of the fish, and rearing and release techniques applied. However, egg, fry or parr releases cannot be used for augmenting populations above the carrying capacity of the water course. To surpass the carrying capacity, the fish should be released as smolts or postsmolts
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Engleka, Kurt A., Deborah Lang, Christopher B. Brown, Nicole B. Antonucci,, and Jonathan A. Epstein. "Neural Crest Formation and Craniofacial Development." In Inborn Errors Of Development. Oxford University PressNew York, NY, 2008. http://dx.doi.org/10.1093/oso/9780195306910.003.0006.

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Abstract Neural crest describes a transitory group of pluripotent epithelial cells that originates from the dorsalmost ridges of the embryonic neural tube. During early development, many of these cells collectively transform to a mesenchymal phenotype, assuming new morphological characteristics distinct from their epithelial neighbors, segregate from the neural tube and stream through speci7c routes into neighboring tissue environments in a wave of proliferation and migration. The resultant cells spread along migratory pathways that may end relatively far from the neural tube of origin. They u
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Dingle, Hugh. "Polymorphisms and Polyphenisms." In Migration. Oxford University PressNew York, NY, 1996. http://dx.doi.org/10.1093/oso/9780195089622.003.0014.

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Abstract In the previous chapter I discussed behavioral and life-history variation in migration unaccompanied by distinct and overt changes in morphology or physiology. In this chapter I shall discuss those instances in which overt changes do occur, concentrat ing on phenotypic expression of differences. The analysis of genotypic variation will be covered fully in the next chapter. The first of the overt changes covered concerns those species in which the morphological capability for migration is retained only for the migratory period, often with remobilization of energy and materials to enhan
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West-Eberhard, Mary Jane. "Assessment." In Developmental Plasticity and Evolution. Oxford University Press, 2003. http://dx.doi.org/10.1093/oso/9780195122343.003.0030.

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A book on developmental plasticity needs a chapter on assessment, if only to show that adaptive environmental assessment occurs. Skepticism regarding the ability of nonhuman organisms to assess conditions well enough to make adaptive decisions has a long history in evolutionary biology, and it has been an important barrier to understanding the evolution of adaptive developmental plasticity. It is worth briefly reviewing this history in order to understand certain preconceptions about assessment that still persist. In the nineteenth century, critics of Darwin’s theory of sexual selection (Darwi
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Conference papers on the topic "Migratory Phenotype"

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Sophie, A., T. Rodolfo, M. Riccardo, L. Stéphane, B. Davide, and M. Carine. "PO-161 Cancer cell migratory phenotype characterisation on IGDQ-expressing surface." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.200.

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Baruah, B., P. Barrett-Lee, C. Smith, R. Nicholson, and S. Hiscox. "CD44-Activated HER-2 Signalling in Tamoxifen Resistant Breast Cancer Cells Promotes a Migratory Phenotype." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-5137.

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Kapellos, Theodoros, Dmytro Sirokha, Valeria Viteri, et al. "Circulating human myeloid cells assume a profibrotic and tissue migratory-prone phenotype in Idiopathic pulmonary fibrosis." In ERS Congress 2024 abstracts. European Respiratory Society, 2024. http://dx.doi.org/10.1183/13993003.congress-2024.pa4287.

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Wadhawan, A., P. Barrett-Lee, C. Smith, R. Nicholson, and S. Hiscox. "Src-Dependent Changes in Beta-Catenin Activity Promote a Migratory Phenotype in Endocrine-Resistant Breast Cancer Cells." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-5143.

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Tsukui, T., K. H. Sun, J. R. Wilson-Kanamori, et al. "Identification of Pathologic Fibroblasts with the Highest Level of ECM Gene Expression and Migratory Phenotype in Pulmonary Fibrosis." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2510.

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Shaw, Lucy A., Andrew P. Gaffney, Helen L. Payne, and Susan A. Burchill. "Abstract 3098: Canonical Wnt signaling is activated during the initiation of the migratory phenotype of Ewing's sarcoma family of tumors (ESFT)." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3098.

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Ampuja, Minna E., Riikka Jokimäki, Emma-Leena Alarmo, Kati Juuti-Uusitalo, and Anne Kallioniemi. "Abstract 1397: BMP4 inhibits the proliferation of breast cancer cells in 3D and induces a migratory phenotype in MDA-MB-231 cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1397.

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Costa, Leonardo, Jürgen Haas, Henriette Rudolph, et al. "The Choroid Plexus Is Permissive for a Preactivated Antigen-Experienced Memory B Cell Subset in Multiple Sclerosis." In Building Bridges in Medical Science 2021. Cambridge Medicine Journal, 2021. http://dx.doi.org/10.7244/cmj.2021.03.001.2.

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Background: The role of B cells in multiple sclerosis (MS) is increasingly recognized. B cells undergo compartmentalized redistribution in blood and cerebrospinal fluid (CSF) during active MS, whereby memory B cells accumulate in the CSF. While B-cell trafficking across the blood– brain barrier has been intensely investigated, cellular diapedesis through the blood–CSF barrier (BCSFB) is incompletely understood. Objectives: To investigate how B cells interact with the choroid plexus to transmigrate into the CSF, we isolated circulating B cells from healthy donors (HC) and MS patients, utilized
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Rattanasinchai, Chotirat, Panida Navasumrit та Mathuros Ruchirawat. "Abstract 3964: Integrin α2-collagen I axis promotes proliferative and migratory phenotypes in intrahepatic cholangiocarcinoma". У Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-3964.

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Shimada, Yoshihisa, Paul Yenerall, Kimberly Avila, et al. "Abstract 907: Uptake of lung cancer exosomes induces migratory and invasive phenotypic changes in lung epithelial cells in an oncogene context dependent manner." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-907.

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