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Dissertations / Theses on the topic 'Mikro RNK'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Zhou, Yu. "Application of RNA Bioinformatics in decoding RNA structure and regulation." Paris 11, 2008. http://www.theses.fr/2008PA112234.

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Ma thèse porte sur le développement de méthodologies informatiques et bioinformatiques pour résoudre des problèmes provenant de questions biologiques liées à l’ARN, telles que la prédiction de structures, l’identification de structures communes, la découverte de cibles des micro-ARN, la prédiction de la régulation de l’épissage, et le design (ou repliement inverse) d'ARN. Le premier chapitre concerne la mise en place d’une méthode itérative pour la prédiction des structures secondaires des introns de groupes 1, incluant les pseudo-nœuds, et la développement d’une base de données complète sur l

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2

Davies, Brian Patrick. "A homogenous fluorescence assay of micro RNA maturation." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2008. http://dx.doi.org/10.18452/15851.

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Micro RNA sind nicht-kodierende dsRNA ~22 Nukleotiden lang, die eine wichtige Rolle in der Entwicklung und Regulation in beinahe allen Eukaryoten spielen. MiRNAs binden target mRNA, was zu einer Blockierung der Proteintranslation führt. Viele Krankheiten sind bekannt, die durch veränderte miRNA Expressionsmuster entweder beeinflusst oder verursacht werden. Demnach könnte eine Manipulation der miRNA-Bildung einen therapeutischen Ansatz darstellen. MiRNA werden im Zytoplasma von längeren haarnadelförmigen prekursor RNA (pre-miRNA) durch das Enzym Dicer freigsetzt. Inhibition dieser Spaltung kön

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3

Andonovic, Lidija [Verfasser]. "Artificial micro RNA system in Dictyostelium discoideum / Lidija Andonovic." Kassel : Universitätsbibliothek Kassel, 2011. http://d-nb.info/1009652893/34.

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4

Sachdeva, Mohit. "Micro RNA-145 is a putative tumor suppressor gene /." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1796420431&sid=16&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Thesis (M.S.)--Southern Illinois University Carbondale, 2009.<br>"Department of Molecular Biology, Microbiology, and Biochemistry." Includes bibliographical references (p. 33-38). Also available online.

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5

SACHDEVA, MOHIT. "MICRO RNA-145 IS A PUTATIVE TUMOR SUPPRESSOR GENE." OpenSIUC, 2009. https://opensiuc.lib.siu.edu/theses/488.

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MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression at the post-transcriptional level by interacting with the 3'-untranslated region (3'-UTR) of a target gene. To date, over 600 human miRNAs have been identified. Recent miRNA profiling studies reveal that while some miRNAs are overexpressed, the others are underexpressed in tumors compared to normal tissues, suggesting that they could play a key role in oncogenesis. Indeed, functional analyses indicate that miRNAs can act to either promote oncogenesis or suppress tumor suppressors. However, our understanding of miRNA-med

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6

Davila, Carolini Kaid. "Expressão de hsa-miR-367 e agressividade de meduloblastoma humano." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-19052015-105630/.

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O meduloblastoma é o tumor cerebral maligno mais comum em crianças de zero a quatro anos e uma das principais causas de morbidade e mortalidade infantil. Diversos estudos têm suportado a hipótese de que a ativação de genes tipicamente expressos em células-tronco confere características mais primitivas e agressivas a células tumorais, frequentemente associadas a prognóstico clínico desfavorável. Nesse contexto, tanto fatores proteicos quanto miRNAs poderiam estimular uma reprogramação em células cancerosas, induzindo um fenótipo semelhantes ao de células-tronco. Estudos recentes apontam o envol

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7

Júnior, Nelson Gaspar Dip. "Análise de expressão de micro RNA em carcinoma urotelial de bexiga." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-10102012-100047/.

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Introdução: O câncer de bexiga é a segunda neoplasia maligna mais frequente do trato urinário, com 386.000 casos estimados e 150.000 mortes para 2011 no mundo. Noventa e cinco por cento são carcinomas uroteliais (CUB) papilíferos não músculo-invasivos de baixo grau, que apresentam altas taxas de recidiva, mas raramente progridem. Tumores invasivos de alto grau representam 10-20% dos diagnósticos, são altamente agressivos levando à mortalidade elevada. O conhecimento das vias moleculares envolvidas na carcinogênese dessa neoplasia é importante para a identificação de novos marcadores para diagn

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8

Hübelt, Jörn, and Christian Schulze. "Lärmminderung bei Mikro-BHKW (SILENA-Studie)." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-139467.

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Der Bericht informiert über eine Untersuchung zum Stand der Lärmminderungstechnik bei Kleinst-Blockheizkraftwerken (BHKW). Kleinst-BHKW kommen verstärkt in Wohngebäuden zum Einsatz, dabei erzeugen sie oftmals störende Geräusche. Problematisch sind der Luft- sowie der Körperschall. Besonders die tieffrequenten Geräusche verlangen spezielle technische Vorkehrungen zum Schallschutz. Das ist möglich durch die Verwendung leiser Aggregate, die richtige Aufstellung der Aggregate, die Dimensionierung der Schalldämpfer und die geeignete Führung des Abgaskanals. Wichtig sind auch technische Mindestanf

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9

Anene, Chinedu A. "Platelet micro-particles induce angiogenesis through the delivery of the micro-RNA Let-7a into endothelial cells." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/16041.

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Cardiovascular disease is a major cause of morbidity and mortality around the globe, which is linked to athero-thrombosis. The risk factors for atherothrombosis, thus cardiovascular disease is impaired anti-thrombotic and antiinflammatory functions of the endothelium. Thrombosis is a hallmark of cardiovascular disease/complications characterised by increased platelet activation and increased secretion of platelet micro-particles that induce angiogenesis. This study determined the role of platelet micro-particles derived microRNA in the regulation of angiogenesis and migration, with a focus on

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10

Harling, Leanne. "Investigating the micro-RNA and metabolic signature of human postoperative atrial fibrillation." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/29130.

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Atrial fibrillation (AF) is the commonest disorder of cardiac rhythm. Following coronary artery surgery approximately 1 in 3 patients will develop de novo post-operative AF (POAF) leading not only to prolonged hospital stay but also to increased morbidity and mortality. The pathophysiology of this arrhythmia is highly complex, and combines factors such as ion channel dysfunction, inflammation, oxidative stress, fibrosis and autonomic dysfunction that through electrical and structural remodelling promote both triggering and maintenance of this arrhythmia. For many years POAF has been regarded a

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11

Tordonato, C. "A NOVEL MICRO-RNA FAMILY AS MOLECULAR DETERMINANT OF MAMMARY STEM CELLS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/264788.

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A novel microRNA family as molecular determinant in mammary stem cells MicroRNAs (miRNAs) are an evolutionarily conserved class of small (18-22 nucleotides) noncoding RNAs involved in the regulation of a variety of cellular and developmental processes. MiRNAs have recently emerged as key regulators of transcriptional programs that control self-renewal and the cell-fate of stem cells (SCs). In the breast compartment, forced expression of some miRNAs (e.g. miR-200, let-7 and miR-93) was shown to inhibit normal and/or cancer SCs by silencing self-renewal determinants. In fact, these miRNAs are

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12

Wright, Jason. "Endothelial-associated microRNA in the critically ill." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23527.

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Background: Micro RNA are short single stranded RNA molecules extensively involved in regulation of gene expression, and may represent biomarkers as well as therapeutic targets. The feasibility of assessing micro RNA expression in critically ill patients is unclear. Objective: To test the feasibility of assessing the micro RNA expression changes in critically ill patients, with a focus on micro RNA previously described as being involved in endothelial function. This pilot study has been done in a small cohort of off pump coronary artery bypass patients, on pump coronary artery bypass patient

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Zanca, Almir Samuel. "Identificação de micro RNAs em cana-de-açucar." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314782.

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Orientadores: Michel Georges Albert Vincentz, Fabio Tebaldi Silveira Nogueira<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-13T11:23:48Z (GMT). No. of bitstreams: 1 Zanca_AlmirSamuel_M.pdf: 11034884 bytes, checksum: 0545b58df6802e07009aef761dda3003 (MD5) Previous issue date: 2009<br>Resumo: RNAs não-codificantes de 20-27 nucleotídeos (nt) regulam transcricionalmente ou pós-transcricionalmente a expressão de genes endógenos, modelando o transcriptoma e a produção de proteínas. Dentre estes, microRNAs (miRNAs) desemp

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14

Rezaei-Lotfi, Saba. "A human-specific micro-rna encoded by notch-1 modulates mitotic checkpoint machinery." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13521.

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An expanded and sophisticated genome has provided the eukaryotes with a highly versatile genetic toolbox to orchestrate complex interaction networks necessary for development and homeostasis of multi-organ systems. The expansion of genome could not happen without significant contribution of mobile genetic elements. It is estimated that up to 50% of human genome is composed of transposable elements. Yet, the absolute dependence of metazoans on transposable elements for genomic expansion and concomitant evolutionary sophistication poses a radical dilemma. Any Expansion phase that is not followe

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15

Mead, Edward. "Discovery, Characterization, and Functional Analysis of micro RNAs in Culicidae." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/77433.

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MicroRNAs (miRNAs) are non-coding RNAs that often play a fundamental role in gene regulation. Currently, hundreds to over a thousand miRNAs are predicted to be present in many eukaryote species, with many to be discovered; the functions of most are unknown. While much attention has gone towards model organisms, a much greater depth of understanding remains to be gained for the miRNAs of many organisms directly important to humans. There are few verified miRNAs for any mosquito species, despite the role of mosquitoes in many of humanity’s worst diseases. Anopheles gambiae and Aedes aegypti, car

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Pokharel, Rounak. "Label Free Micro-RNA Biomarker Detection in Serum Samples for Potential Diagnosis Application at Point-of-Care Settings." Thesis, North Dakota State University, 2020. https://hdl.handle.net/10365/31880.

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The number of new cancer cases is projected to rise to 23.6 million by 2030 according to the National Cancer Institute. Obesity & cardiovascular diseases are among the leading causes of death worldwide according to recent reports. Biomarkers— any molecules found within a human body that can be used to monitor an individual's health — have been shown to play a significant role in the detection of cancer, obesity, and cardiovascular diseases. Recent studies have shown that in the diagnosis and screening of various human diseases, including cancer, obesity and cardiovascular diseases, circulatin

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Cannizzo, Carla Maria. "MicroRNAs: Markers and Mediators of Wound Healing in Diabetes." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25885.

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Chronic non-healing foot ulcers are a major complication of diabetes, occurring in 25% of patients within their lifetime. A common feature that underpins poor wound healing in diabetes is inadequate vascularisation due to diabetes-impaired angiogenesis. Currently there are no adequate biomarkers and effective therapies that improve diabetes-impaired healing. The ability to better identify and treat these wounds would reduce the risk of developing co-morbidities such as lower limb amputations. microRNAs (miRNAs) have been indicated to be reliable biomarkers and have been shown to be dysregulat

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18

Thakare, P. "¿DESIGN AND SYNTHESIS OF MODIFIED PEPTIDE NUCLEIC ACID (PNAS) WITH IMPROVED PHYSICO-CHEMICAL PROPERTIES FOR DNA, RNA AND MICRO RNA TARGETING¿." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/474378.

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The present dissertation is divided into four chapters. Chapter one deals with the introduction to Peptide Nucleic Acid (PNA) its properties and its applications. The second chapter deals with the synthesis of modified PNAs with and without fluorescein isothiourea and its kinetic studies by using stopped-flow technique. The third chapter deals with the design, synthesis and characterization of functionalized PNAs with heterobifunctional linker and their conjugation with magnetic nanoparticles (MNPs) for miRNA targeting. The fourth chapter deals with design and synthesis of modified thymine mon

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19

Hawlik, Rainer Christian [Verfasser]. "Verbesserung der Photorezeptorsegmententwicklung in humanen Retinaorganoiden durch Überexpression des Mikro-RNA Clusters 183/96/182 / Rainer Christian Hawlik." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1223451585/34.

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20

Samweber, Julia [Verfasser], and Simone [Akademischer Betreuer] Kreth. "Bedeutung der micro-RNA 93 im Krankheitsbild der Sepsis / Julia Samweber ; Betreuer: Simone Kreth." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/120306733X/34.

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Mody, Hardik R. "Investigation of Micro-RNA-based Approaches to Overcome Epithelial-Mesenchymal Transition in Pancreatic Cancer." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1502908907944535.

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22

Amaral, Murilo Sena. "Identificação de RNAs longos não-codificadores de proteínas regulados por micro-RNAs." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-22102014-102412/.

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Estudos recentes têm revelado que a maior parte dos transcritos gerados em células humanas é composta por RNAs não-codificadores de proteínas (ncRNAs). Uma parte desses ncRNAs compreende a classe de RNAs curtos, que possuem menos que 200 nucleotídeos. Os micro-RNAs (miRNAs) fazem parte dessa classe e têm sido alvo de grande interesse, pois são preditos como possíveis reguladores de mais de 60% dos RNAs mensageiros (mRNAs) humanos. Outra classe dos ncRNAs é composta por ncRNAs longos (lncRNAs, com mais de 200 nucleotídeos), que são transcritos a partir de regiões intergênicas e intrônicas do ge

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23

Meier, Jan [Verfasser], and Stefan [Akademischer Betreuer] Wiemann. "Elucidation of regulatory micro-RNA/ messenger-RNA networks in B-cell chronic lymphocytic leukemia and mantle cell lymphoma / Jan Meier ; Betreuer: Stefan Wiemann." Heidelberg : Universitätsbibliothek Heidelberg, 2012. http://d-nb.info/1177808897/34.

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24

Sharma, Kanika. "Identification of micro-RNAs and their messenger RNA targets in Prostate cancer and Biological fluids." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3551.

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Prostate cancer is the second most common cancer in the United States that affects men today. To better treat this disease accurate biomarkers and successful therapeutic treatments are needed. A novel approach to understand the mechanisms behind prostate cancer tumor formation lies in identifying dysregulated micro-RNAs (miRNAs), which are a class of small (18-24 nucleotides) non-coding RNAs that regulate gene expression posttranscriptionally by either inhibiting protein synthesis or signaling messenger-RNA for degradation. Multiple miRNAs were discovered in our highly tumorigenic and metastat

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Tomiyama, Alberto Hiroyuki. "Micro RNA em adenocarcinoma de próstata: caracterização da expressão em tumores de baixo grau, órgão-confinados." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-07022012-112055/.

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Introdução: Os micro RNA (miRNA) são formados a partir de RNA precursores de fita dupla que contém entre 60 a 110 nucleotídeos e formam estruturas do tipo hairpin. Imediatamente após sua transcrição pela RNA polimerase II a enzima Dicer promove a clivagem do RNA precursor em seqüências menores contendo 19 a 22 nucleotídeos. Após a clivagem, o miRNA integra-se ao complexo silenciador induzido pelo RNA (RISC) que o conduz ao seu RNA mensageiro (mRNA) homólogo recém transcrito. Esta associação promove a degradação do mRNA, ou interfere na tradução da proteína caracterizando um grande mecanismo de

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Grzesiuk, Juliana Dourado. "Investigação genômica de pacientes inférteis com oligozoospermia." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-30032017-162247/.

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A infertilidade afeta aproximadamente 15% dos casais, sendo atualmente reconhecido o envolvimento de fatores masculinos em metade dos casos. Alterações nas análises seminais são detectadas na maioria dos homens inférteis e a mais frequente é a baixa concentração de espermatozoides no ejaculado, conhecida como oligozoospermia. Vários estudos mostram uma forte relação entre fatores genéticos e a infertilidade, incluindo alterações cromossômicas e microdeleções do cromossomo Y, porém as causas da oligozoospermia ainda permanecem obscuras. O desenvolvimento de novas tecnologias de investigação vem

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Prestes, Priscilla. "Genetic and epigenetic changes associated with polygenic left ventricular hypertrophy." Thesis, Federation University Australia, 2021. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/178821.

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Cardiac hypertrophy (CH) is the thickening of heart muscles reducing functionality and increasing risk of cardiac disease. Commonly, pathological CH is presented as left ventricular hypertrophy (LVH) and genetic factors are known to be involved but their contribution is still poorly understood. I used the hypertrophic heart rat (HHR), a unique normotensive polygenic model of LVH, and its control strain, the normal heart rat (NHR) to investigate genetic and epigenetic contributions to LVH independent of high blood pressure. To address this study, I used a systematic approach. Firstly, I sequenc

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Tekaya, Hamouda Nedra. "Identification et étude d'un nouveau mécanisme nucléaire de régulation post-transcriptionnelle par les micro-ARN." Thesis, Nice, 2016. http://www.theses.fr/2016NICE4007/document.

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Les miARN sont de petits ARN non codant dont la taille varie entre 21-24 nucléotides. Ils jouent un rôle de régulateurs post-transcriptionnels en utilisant leur complémentarité de séquence avec l’ARN messager (ARNm) cible afin d’induire sa répression. Grâce à la protéine Argonaute 2 (Ago2) dans laquelle les miARN sont incorporés formant ainsi le complexe miRISC, des cofacteurs sont recrutés afin d’induire la dégradation ou le blocage de la traduction de l’ARNm cible. Initialement connus pour réguler leurs cibles dans le cytoplasme, les miARN sont de plus en plus décrits comme étant des régulat

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Duarte, Rubens Tadeu Delgado. "Micro-organismos em ambientes criogênicos: gelo glacial, solos expostos por recuo de geleiras, e permafrost polares." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-07102010-153139/.

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O efeito de alterações climáticas sobre os micro-organismos ainda é incerto, pois pouco se conhece sobre as espécies que habitam regiões extremas como o gelo, solo antártico, e o solo permanentemente congelado (permafrost). O permafrost tem como característica a preservação de material biológico por milhões de anos, servindo como fonte para estudos de evolução e biogeografia de micro-organismos. O objetivo deste trabalho foi estudar a diversidade microbiana em amostras de gelo, solo exposto por recuo de geleira e permafrost polares, e a diversidade funcional do gene alcano monoxigenase (alk).

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Götschke, Jeremias [Verfasser], and Susanne [Akademischer Betreuer] Krauss-Etschmann. "Beschreibung eines potentiellen micro-RNA-basierten Biomarkers für allergisches Asthma / Jeremias Götschke ; Betreuer: Susanne Krauss-Etschmann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/115653352X/34.

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Robertson, Fiona Catherine. "Selective targeting of micro RNA-regulated plant development by the 2b protein of Cucumber mosaic virus." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613182.

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Paiva, Francisco Cleiton da. "Gestão socioambiental em micro e pequenas indústrias de Pau dos Ferros-RN." Universidade Federal Rural do Semi-Árido, 2016. http://bdtd.ufersa.edu.br:80/tede/handle/tede/554.

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Submitted by Socorro Pontes (socorrop@ufersa.edu.br) on 2017-02-07T14:23:37Z No. of bitstreams: 1 FranciscoCSP_DISSERT.pdf: 1619582 bytes, checksum: 50b9d0a1b7e7d11624b92a429c12f091 (MD5)<br>Made available in DSpace on 2017-02-07T14:23:37Z (GMT). No. of bitstreams: 1 FranciscoCSP_DISSERT.pdf: 1619582 bytes, checksum: 50b9d0a1b7e7d11624b92a429c12f091 (MD5) Previous issue date: 2016-02-29<br>This study aimed to analyze the manager‟s perception of micro and small industries companies regarding to social and environmental practices in the city of Pau dos Ferros-RN. It sought to verify whether

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Oliveira, Antonio Martins. "Otimização da autólise de Saccharomyces cerevisiae de cervejaria e extração de RNA /." Rio Claro : [s.n.], 2008. http://hdl.handle.net/11449/103983.

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Orientador: Pedro de Oliva Neto<br>Banca: Iolanda Cristina Silveira Duarte<br>Banca: Maria das Graças de Almeida Felipe<br>Banca: Eleonora Cano Carmona<br>Banca: Crispin Humberto Garcia Cruz<br>Resumo: O presente trabalho teve por objetivo otimizar a autólise de levedura fresca de cervejaria (Saccharomyces cerevisiae), visando a extração máxima de ácido ribonucléico da biomassa na produção do extrato de levedura. As variáveis estudadas foram pH, temperatura, % de NaCl, % de NH3, tempo de processo e, métodos de recuperação de RNA do autolisado. Os experimentos foram realizados por meio de quatr

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Utzinger, Maximilian [Verfasser], and Gerhard [Akademischer Betreuer] Winter. "PLGA-based micro- and nanoparticle development for chemically modified messenger RNA delivery / Maximilian Utzinger ; Betreuer: Gerhard Winter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1132995353/34.

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Hundewale, Nisar. "CAD Tools for DNA Micro-Array Design, Manufacture and Application." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/cs_diss/13.

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Motivation: As the human genome project progresses and some microbial and eukaryotic genomes are recognized, numerous biotechnological processes have attracted increasing number of biologists, bioengineers and computer scientists recently. Biotechnological processes profoundly involve production and analysis of highthroughput experimental data. Numerous sequence libraries of DNA and protein structures of a large number of micro-organisms and a variety of other databases related to biology and chemistry are available. For example, microarray technology, a novel biotechnology, promises to monito

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Franklin, Oskar. "Stromal components and micro-RNAs as biomarkers in pancreatic cancer." Doctoral thesis, Umeå universitet, Kirurgi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128000.

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Background Pancreatic ductal adenocarcinoma (PDAC) patients have the poorest 5-year survival rates of all cancer forms. It is difficult to diagnose at early disease stages, tumour relapse after surgery is common, and current chemotherapies are ineffective. Carbohydrate antigen 19-9 (Ca 19-9), the only clinically implemented PDAC biomarker, is insufficient for diagnostic and screening purposes. PDAC tumours are characterised by a voluminous stroma that is rich in extracellular matrix (ECM) molecules such as collagens, hyaluronan (HA) and matricellular proteins. These stromal components have bee

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Almairac, Fabien. "Plasticité des cellules tumorales de glioblastomes : inter-conversion d’un phénotype différencié et souche en fonction du microenvironnement." Thesis, Nice, 2016. http://www.theses.fr/2016NICE4045/document.

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L’objectif de ce travail était de démontrer que les cellules de glioblastomes sont capables de se différencier et de se dédifférencier en fonction de leur environnement, d’explorer les mécanismes biologiques qui sous-tendent ces transitions, et d’évaluer in vivo les capacités de différenciation à distance des CIG par les CIG-miR-302-367 via la sécrétion de microvésicules. A partir de plusieurs glioblastomes fraichement réséqués, nous avons caractérisé les cellules tumorales sur le plan phénotypique et fonctionnel pour l’état souche et différencié. Nous avons extraits et analysés les microvésic

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Ahmed, Raza. "Epithelial distribution of foot-and-mouth disease virus RNA determined using laser micro-dissection and quantitative RT-PCR." Thesis, University of Surrey, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442663.

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Davies, Brian Patrick [Verfasser], Christoph [Gutachter] Arenz, Sabine [Gutachter] Müller, and Oliver [Gutachter] Seitz. "A homogenous fluorescence assay of micro RNA maturation / Brian Patrick Davies ; Gutachter: Christoph Arenz, Sabine Müller, Oliver Seitz." Berlin : Humboldt-Universität zu Berlin, 2008. http://d-nb.info/1208076604/34.

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Gazon, Helène. "Étude de la régulation d’HBZ et son rôle sur la biogénèse des miARN chez les patients infectés par HTLV-1." Thesis, Antilles-Guyane, 2014. http://www.theses.fr/2014AGUY0806/document.

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HTLV-1, un rétrovirus endémique des Antilles-Guyane qui infecte plus de 10 millions de personnes dans le monde, est l’agent étiologique de l’ATL, une leucémie agressive des lymphocytes T CD4+ résistante aux traitements conventionnels actuels. Le rôle émergent des miARN dans la leucémogénèse et la résistance aux chimiothérapies a soulevé des interrogations quant à leurs rôles dans le développement de l’ATL. Les miARN sont de petits ARN non codant qui régulent l’expression génique. Récemment leur altération durant le cycle de vie du HTLV-1 a été mise en lumière. Une des caractéristiques de l’éme

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Brüggemann, Mirko [Verfasser], Katharina [Akademischer Betreuer] Zarnack, Ingo [Akademischer Betreuer] Ebersberger, Katharina [Gutachter] Zarnack, and Ingo [Gutachter] Ebersberger. "Computational studies on RNA processing in higher eukaryotes / Mirko Brüggemann ; Gutachter: Katharina Zarnack, Ingo Ebersberger ; Katharina Zarnack, Ingo Ebersberger." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2021. http://nbn-resolving.de/urn:nbn:de:hebis:30:3-613842.

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Lagadinos, Alexander N. "Human Cytomegalovirus Reprograms the Expression of Host Micro-RNAs whose Target Networks are Required for Viral Replication: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/683.

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The parasitic nature of viruses requires that they adapt to their host environment in order to persist. Herpesviruses are among the largest and most genetically complex human viruses and they have evolved mechanisms that manipulate a variety of cellular pathways and processes required to replicate and persist within their hosts. Human cytomegalovirus (HCMV), a member of the β- herpesvirus sub-family, has the capacity to influence the expression of many host genes in an effort to create an optimal environment for infection. One mechanism utilized by HCMV to alter gene expression is the host RNA

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Lagadinos, Alexander N. "Human Cytomegalovirus Reprograms the Expression of Host Micro-RNAs whose Target Networks are Required for Viral Replication: A Dissertation." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/683.

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The parasitic nature of viruses requires that they adapt to their host environment in order to persist. Herpesviruses are among the largest and most genetically complex human viruses and they have evolved mechanisms that manipulate a variety of cellular pathways and processes required to replicate and persist within their hosts. Human cytomegalovirus (HCMV), a member of the β- herpesvirus sub-family, has the capacity to influence the expression of many host genes in an effort to create an optimal environment for infection. One mechanism utilized by HCMV to alter gene expression is the host RNA

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Canlorbe, Geoffroy. "Détermination sur tissu endométrial néoplasique de profils d'expression de micro-ARNs associés à l'envahissement ganglionnaire dans le cancer de l'endomètre de type endométrioïde de stade précoce." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066198/document.

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La classification du cancer de l'endomètre, basée sur l'histologie, conditionne la prise en charge thérapeutique alors qu'elle ne montre pas une pertinence suffisante pour prédire l'envahissement ganglionnaire. La détermination de profils d'expression biologiques corrélés au statut ganglionnaire et à d'autres facteurs pronostiques majeurs tels que les emboles apparait donc fondamentale pour mieux adapter la prise en charge. Nous avons montré, par une analyse de puce à partir des ARNs extraits de tissus sous paraffine de cancer de l'endomètre de type endométrioide, de grade 1-2, supposé limité

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Baghdadi, Meryem. "Régulation de la quiescence des cellules souches du muscle squelettique par la voie Notch." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066461/document.

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Le muscle squelettique adulte est capable de se régénérer à plusieurs reprises après blessure grâce à sa population de cellules souches résidentes: les cellules satellites. Cependant, les mécanismes impliquant les cellules satellite dans la recouvrement de l'homéostasie et de l'intégrité musculaire ne sont toujours pas clairs. Chez l'adulte, les cellules satellites sont quiescentes et localisées dans une niche entre la lame basale et la fibre musculaire. Après blessure, elles prolifèrent, se différencient et fusent afin de restaurer les fibres endommagées. Lorsque la niche des cellules satelli

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Matégot, Raphaël. "Contrôle de l’expression des gènes par les micro-ARN nucléaires : étude des mécanismes moléculaires." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4059/document.

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La découverte de l’ARN interférence et des micro-ARN a permis de définir un principe majeur de régulation de l’expression des gènes, et a produit de nouveaux outils pour la médecine. Chez les mammifères, l’étude des fonctions des micro-ARN a été restreinte au cytoplasme, bien qu’ils soient aussi présents dans le noyau.Cette thèse présente une série d’expériences visant à caractériser les facteurs moléculaires requis pour l’activité nucléaire des micro-ARN. Nous avons débuté ce projet en explorant les partenaires ARN-dépendant de la protéine AGO2 par immunoprécipitation et spectrométrie de mass

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Sueur, Gabrielle. "La phosphatase CDC25A et le micro-ARN-16 au coeur de la biologie des leucémies aiguës myéloïdes portant une mutation FLT3-ITD." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30156.

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Les patients présentant une Duplication Interne en Tandem dans le récepteur FLT3 (FLT3-ITD) représentent 25% des cas de Leucémie Aiguë Myéloïde (LAM), et ont un mauvais pronostic de survie par rapport aux patients exprimant le récepteur sauvage. Notre équipe a précédemment identifié la phosphatase CDC25A comme une cible précoce du récepteur muté et un acteur essentiel de la biologie de ces LAM. Les inhibiteurs pharmacologiques de CDC25A disponibles n'étant pas utilisables en clinique, nous avons donc décidé d'étudier plus en détail la voie de signalisation FLT3-ITD/CDC25A afin de trouver une a

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Tekaya, Hamouda Nedra. "Identification et étude d'un nouveau mécanisme nucléaire de régulation post-transcriptionnelle par les micro-ARN." Electronic Thesis or Diss., Nice, 2016. http://theses.unice.fr/2016NICE4007.

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Les miARN sont de petits ARN non codant dont la taille varie entre 21-24 nucléotides. Ils jouent un rôle de régulateurs post-transcriptionnels en utilisant leur complémentarité de séquence avec l’ARN messager (ARNm) cible afin d’induire sa répression. Grâce à la protéine Argonaute 2 (Ago2) dans laquelle les miARN sont incorporés formant ainsi le complexe miRISC, des cofacteurs sont recrutés afin d’induire la dégradation ou le blocage de la traduction de l’ARNm cible. Initialement connus pour réguler leurs cibles dans le cytoplasme, les miARN sont de plus en plus décrits comme étant des régulat

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Lema, Ingrid. "Contrôle post-transcriptionnel de l'expression rénale du récepteur minéralocorticoide par les variations de tonicité extracellulaire : conséquences physiopathologiques." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS290.

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L’aldostérone et le Récepteur Minéralocorticoïde (MR) participent au contrôle de la balance hydrosodée et de la pression artérielle. Les altérations de l’expression du MR ou de la signalisation minéralocorticoïde sont associées à de nombreuses pathologies chez l’Homme. Dans ce travail, nous avons démontré, le rôle majeur de protéines de liaison à l’ARN, Tis11b et HuR, dans le contrôle post-transcriptionnel de l’expression du MR en réponse aux variations de tonicité extracellulaire dans un modèle de cellules principales rénales et chez la souris. L’hypertonicité (500 mOsmol/L) induit l’expressi

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Szarzynska, Bogna, Lukasz Sobkowiak, Bikram Datt Pant, et al. "Gene structures and processing of Arabidopsis thaliana HYL1-dependent pri-miRNAs." Universität Potsdam, 2009. http://opus.kobv.de/ubp/volltexte/2010/4508/.

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Arabidopsis thaliana HYL1 is a nuclear doublestranded RNA-binding protein involved in the maturation of pri-miRNAs. A quantitative real-time PCR platform for parallel quantification of 176 primiRNAs was used to reveal strong accumulation of 57 miRNA precursors in the hyl1 mutant that completely lacks HYL1 protein. This approach enabled us for the first time to pinpoint particular members of MIRNA family genes that require HYL1 activity for efficient maturation of their precursors. Moreover, the accumulation of miRNA precursors in the hyl1 mutant gave us the opportunity to carry out 3’ and 5’ R

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