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1

Burns, Jeffrey M. Mild cognitive impairment and early Alzheimer's disease: Detections and diagnosis. John Wiley & Sons, 2008.

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2

Holly, Tuokko, and Hultsch David F, eds. Mild cognitive impairment: International perspectives. Taylor & Francis, 2006.

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3

Burns, Jeffrey M. Early diagnosis and treatment of mild cognitive impairment. John Wiley & Sons, 2008.

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Burns, Jeffrey M. Early diagnosis and treatment of mild cognitive impairment. John Wiley & Sons, 2008.

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5

Lars-Olof, Wahlund, Erkinjuntti Timo, and Gauthier Serge 1950-, eds. Vascular cognitive impairment in clinical practice. Cambridge University Press, 2009.

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6

Morris, John, and Jeffrey Burns. Mild Cognitive Impairment. Wiley, 2007.

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7

Libon, David J., Melissa Lamar, Rodney A. Swenson, and Kenneth M. Heilman, eds. Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190634230.001.0001.

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Alzheimer’s disease and vascular dementia are acknowledged as the two most common types of dementia. Each of these dementia syndromes are associated with prodromal clinical syndromes, often referred to as mild cognitive impairment. Recent research has demonstrated considerable heterogeneity regarding the underlying neuropathology associated with these dementia syndromes and their prodromal disorders. Thus, it is often difficult to understand how or what underlying biological substrate is actually responsible for the alterations in neurocognition and behaviour as seen in clinical evaluations. T
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8

Kanow, Cora, and Ronald C. Petersen. Mild Cognitive Impairment: Aging to Alzheimer's Disease. Oxford University Press, 2003.

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9

Mild Cognitive Impairment: Aging to Alzheimer's Disease (Medicine). Oxford University Press, USA, 2003.

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10

Tuokko, Holly A., and David F. HULTSCH. Mild Cognitive Impairment. Taylor & Francis Group, 2020.

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11

Burns, J. M. Early Diagnosis and Treatment of Mild Cognitive Impairment. Wiley & Sons, Limited, John, 2008.

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12

Hultsch, David F., and Holly A. Tuokko. Mild Cognitive Impairment: International Perspectives. Taylor & Francis Group, 2020.

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13

Tuokko, Holly A., and David F. HULTSCH. Mild Cognitive Impairment: International Perspectives. Taylor & Francis Group, 2020.

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14

Hultsch, David F., and Holly A. Tuokko. Mild Cognitive Impairment: International Perspectives. Taylor & Francis Group, 2013.

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15

C, Morris John, and Jeffrey M. Burns. Mild Cognitive Impairment and Early Alzheimer's Disease: Detection and Diagnosis. Wiley & Sons, Incorporated, John, 2008.

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16

Mild cognitive impairment: A useful construct for predicting alzheimer's disease. National Library of Canada, 2002.

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17

Libon, David, Melissa Lamar, Rodney A. Swenson, and Kenneth M. Heilman. Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment: Advancing an Integrated Approach. Oxford University Press, Incorporated, 2020.

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18

Hultsch, David F., and Holly A. Tuokko. Mild Cognitive Impairment: International Perspectives. Taylor & Francis Group, 2013.

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19

Hultsch, David F., and Holly A. Tuokko. Mild Cognitive Impairment: International Perspectives. Taylor & Francis Group, 2015.

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20

Tuokko, Holly A., and David F. HULTSCH. Mild Cognitive Impairment: International Perspectives. Taylor & Francis Group, 2020.

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21

Hultsch, David F., and Holly A. Tuokko. Mild Cognitive Impairment: International Perspectives. Taylor & Francis Group, 2019.

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22

Hultsch, David F., and Holly A. Tuokko. Mild Cognitive Impairment: International Perspectives. Taylor & Francis Group, 2013.

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23

Hultsch, David F., and Holly A. Tuokko. Mild Cognitive Impairment: International Perspectives. Taylor & Francis Group, 2013.

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24

Hultsch, David F., and Holly A. Tuokko. Mild Cognitive Impairment: International Perspectives. Taylor & Francis Group, 2019.

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25

O’Brien, John T., and Louise Grayson. Mild Cognitive Impairment and predementia syndromes. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199644957.003.0032.

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Mild cognitive impairment is a term used to describe a condition or conditions where subjects have recognisable degrees of objective cognitive impairment which fall short of current standardised definitions for either a dementia syndrome in general, or for particular disorders such as Alzheimer’s disease, dementia with Lewy bodies or frontotemporal dementia. This chapter summarises some of the key issues surrounding the historical development of pre-dementia syndromes, considers the conceptual issues related to the use of the term mild cognitive impairment as a diagnosis, summarises what is kn
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26

Melikyan, Zara, Heather Romero, and Kathleen A. Welsh-Bohmer. Cognitive Enhancement at the Mild Cognitive Impairment Stage of Alzheimer’s Disease. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190214401.003.0008.

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Alzheimer’s disease (AD) is the most common cause of dementia in aging. Currently, therapeutic interventions are being initiated earlier in the disease course. The rationale of this strategy is to take advantage of the still healthy neuronal systems to optimize function, slow cognitive decline, and facilitate adaptive compensation in deficient brain networks. This chapter provides an overview and critique of the evidence supporting the enhancement of cognitive function at the early symptomatic stage of AD, so-called mild cognitive impairment due to AD (MCI-AD). It reviews the clinical diagnosi
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27

Hultsch, David F., and Holly A. Tuokko. Perspectives on Mild Cognitive Impairment (Studies on Neuropsychology, Neurology and Cognition). Psychology Press, 2006.

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28

Steinberg, Martin, and Paul B. Rosenberg. Cognitive Impairment and Depression. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199959549.003.0001.

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Depression, mild cognitive impairment (MCI) and dementia in the elderly can present with similar features such as cognitive complaints, loss of initiative, and difficulties with psychosocial functioning. These can be difficult to distinguish in the office setting, especially when mild in severity. The relationships between the three syndromes remains incompletely understood. Patients with MCI are at high risk for conversion to dementia. Depression may be either a risk factor for or early manifestation of MCI. Depression in late life is associated with Alzheimer’s disease (AD) and other dementi
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29

Steinberg, Martin, and Paul B. Rosenberg. Cognitive Impairment and Depression in Older Patients. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199959549.001.0001.

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Depression, mild cognitive impairment (MCI) and dementia in the elderly can present with similar features such as cognitive complaints, loss of initiative, and difficulties with psychosocial functioning. These can be difficult to distinguish in the office setting, especially when mild in severity. The relationships between the three syndromes remains incompletely understood. Patients with MCI are at high risk for conversion to dementia. Depression may be either a risk factor for or early manifestation of MCI. Depression in late life is associated with Alzheimer’s disease (AD) and other dementi
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30

Waldemar, Gunhild. Diagnosing Alzheimer’s disease in clinical practice. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198779803.003.0006.

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The diagnostic evaluation in a patient with cognitive impairment suspected of having Alzheimer’s disease (AD) should include investigations aimed at 1) confirming and characterizing the cognitive impairment using cognitive tests with particular attention to typical (episodic memory impairment) and atypical presentations of AD; 2) checking the diagnostic criteria for AD and considering biomarkers to document AD pathology; and 3) differential diagnosis: ruling out other conditions which could cause cognitive impairment. With the advent of CSF and imaging biomarkers for AD, it may be possible to
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31

Anton, Anna, and Dataskrekk Publishing. Easy Coloring: A Coloring Book for People with Mild Cognitive Impairment, Alzheimer's Disease, Older People, or People with Beginning Dementia. Independently Published, 2019.

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32

Psychosocial studies of the individual's changing perspectives in Alzheimer's disease. Medical Information Science Reference, 2015.

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33

Kozauer, Nicholas, and Karl Broich. Regulatory Issues in Cognitive Enhancement Treatment Development. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190214401.003.0016.

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Improvement of cognition by medicinal products is an accepted concept by regulatory agencies. In dementing conditions such as Alzheimer’s disease, improvement of cognition or slowing its deterioration is essential for approval, particularly in early and mild to moderate stages of Alzheimer’s disease. In conditions such as schizophrenia or major depression, treatment of cognitive impairment is not considered as a pseudospecific indication, and specific clinical trials for such an indication are underway. Assessment tools for measurements of change in cognition and its relevance in functional or
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34

Nageshwaran, Sathiji, Heather C. Wilson, Anthony Dickenson, and David Ledingham. Dementia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199664368.003.0011.

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This chapter discusses the clinical features and evidence-based pharmacological management of dementia disorders (Alzheimer’s disease (AD), vascular dementia, dementia with Lewy bodies (DLB), Parkinson’s disease dementia (PDD), frontotemporal dementia (FTD), mixed dementia, and mild cognitive impairment (MCI)).
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35

Blumen, Helena M. Collaborative Memory Interventions for Age-Related and Alzheimer’s Disease-Related Memory Decline. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198737865.003.0024.

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This chapter discusses the potential for using collaboration as a tool to compensate for age-related and Alzheimer’s disease (AD) related memory decline. Recent research suggest that collaborating with others during recall improves later individual memory, but such post-collaborative recall benefits must be confirmed in AD, and transitional stages of AD such as amnestic mild cognitive impairment (aMCI). Identifying the neural systems that operate during collaboration is also essential for determining the therapeutic value of collaborative recall in these populations. Examining post-collaborati
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36

Markus, Hugh, Anthony Pereira, and Geoffrey Cloud. Vascular dementia. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198737889.003.0015.

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Patients with cerebrovascular disease can develop dementia in the absence of stroke symptoms or as a consequence to stroke. In this chapter, concepts, classification, and definitions of vascular dementia are outlined with a discussion of the overlap between vascular dementia and Alzheimer's disease. Investigation of the vascular dementia patient for treatable causes and to inform management is discussed as there are sections on therapy, promoting independence, and assessments of mental capacity. Depression is common in vascular dementia and a section is dedicated to the assessment and manageme
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37

Rosenberg, Paul B. What are the First Signs and Symptoms of Dementia? Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199959549.003.0003.

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Mild cognitive impairment (MCI) is a syndrome where persons have mild cognitive complaints and deficits on exam but are still functioning well in their daily lives. Persons with MCI are at markedly increased risk of developing dementia in the near-term and thus are an important target for preventive interventions. In the office it is crucial to take a careful history and to have an informant (usually a family member). Prodromal Alzheimer’s disease is typified by problems in short-term recall likely due to hippocampal dysfunction, and depression and anxiety are relatively common. Brief cognitiv
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38

Hodges, John R. Illustrative Cases. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198749189.003.0008.

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This chapter comprises 16 case histories that illustrate methods of assessment described in the rest of this book and the use of the Addenbrooke’s Cognitive Examination (ACE)-III. Each case begins with a brief history from the patient and observations by the family followed by findings on cognitive examination focusing on the profile shown on the ACE-III, the results of imaging investigations, and a discussion of the diagnosis and its differential, with a final summary of the principal conclusions, indicating whether the services of a neuropsychologist are required or not. The cases present im
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39

Hilsabeck, Robin C., and Gayle Y. Ayers, eds. Dementia. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780197690024.001.0001.

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Abstract Adults aged 65 and older are the fastest-growing segment of the United States population. This increase in older adults will result in a greater number of individuals with age-related neurocognitive disorders such as Alzheimer’s, vascular disease, and frontotemporal lobular degeneration. The purpose of this book is to provide trainees and early career professionals, particularly in psychiatry, psychology, neurology, geriatrics, family medicine, and internal medicine, with the information necessary to care for the often complex clinical presentations of older adults with mild cognitive
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40

Cunnane, Stephen C., Alexandre Courchesne-Loyer, Valerie St-Pierre, Camille Vandenberghe, Etienne Croteau, and Christian-Alexandre Castellano. Glucose and Ketone Metabolism in the Aging Brain. Edited by Jong M. Rho. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0015.

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Brain glucose uptake is impaired in Alzheimer’s disease (AD). A key question is whether cognitive decline could be delayed if this defect were at least partly corrected or bypassed. Ketones (or ketone bodies) such as beta-hydroxybutyrate and acetoacetate are the brain’s main alternative fuels. Several studies have shown that in mild-to-moderate AD, brain ketone uptake is similar to that of healthy age-matched controls. Published clinical trials show that increasing ketone availability to the brain via nutritional ketosis has modest benefits on cognitive outcomes in mild-to-moderate AD and in m
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41

Hughes, Julian C. Dementia is Dead, Long Live Ageing. Edited by K. W. M. Fulford, Martin Davies, Richard G. T. Gipps, et al. Oxford University Press, 2013. http://dx.doi.org/10.1093/oxfordhb/9780199579563.013.0049.

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Dementia is dead, long live aging! This chapter sets out the philosophical sources for understanding working with "dementia." The concept, "dementia," serves no useful purpose. Even "Alzheimer's disease" turns out to be problematic. This is because there is a lack of precision around the boundaries of these notions. The messiness that surrounds these notions, in terms of facts and values, is made obvious when we consider mild cognitive impairment, which is said to be a pre-dementia state. It makes more biological sense to think in terms of the ageing brain, rather than to search for discrete d
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42

Ames, David, Edmond Chiu, Marshal F. Folstein, and Lars Gustafson. Cerebrovascular Disease Cognitive Impairment and Dementia. Taylor & Francis Group, 2003.

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43

Passaro, Antony, Foteini Christidi, Vasiliki Tsirka, and Andrew C. Papanicolaou. White Matter Connectivity. Edited by Andrew C. Papanicolaou. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199764228.013.5.

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The applications of diffusion tensor imaging (DTI) have increased considerably among both normal and diverse neuropsychiatric populations in recent years. In this chapter, the authors examine the contributions of DTI in identifying profiles of trait-specific connectivity in several groups defined in terms of gender, age, handedness, and general intelligence. Additionally, the DTI literature is reviewed across a range of neurodegenerative disorders including Alzheimer’s disease, mild cognitive impairment, frontotemporal dementia, Parkinson disease, multiple sclerosis, and acquired neurological
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44

(Editor), Ranjan Duara, and David Loeweinstein (Editor), eds. Mild Cognitive Impairment: Early Diagnosis and Treatment (Neurological Disease and Therapy). Informa Healthcare, 2010.

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45

New Ultimate Alzheimer's Disease Cookbook: Recipes to Help in Reversing Cognitive Impairment and Alzheimer's Disease. Independently Published, 2021.

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46

Erkinjuntti, Timo, Serge Gauthier, and Lars-Olof Wahlund. Vascular Cognitive Impairment in Clinical Practice. Cambridge University Press, 2009.

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47

Erkinjuntti, Timo, Serge Gauthier, and Lars-Olof Wahlund. Vascular Cognitive Impairment in Clinical Practice. Cambridge University Press, 2009.

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48

Erkinjuntti, Timo, Serge Gauthier, and Lars-Olof Wahlund. Vascular Cognitive Impairment in Clinical Practice. Cambridge University Press, 2009.

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49

Erkinjuntti, Timo, Serge Gauthier, and Lars-Olof Wahlund. Vascular Cognitive Impairment in Clinical Practice. Cambridge University Press, 2009.

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50

Erkinjuntti, Timo, Serge Gauthier, and Lars-Olof Wahlund. Vascular Cognitive Impairment in Clinical Practice. Cambridge University Press, 2009.

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