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Dissertations / Theses on the topic 'Mild Cognitive Impairment Alzheimer's disease'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Netson, Kelli L. "Characterizing semantic memory in mild cognitive impairment." Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/netson.pdf.

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Thesis (Ph. D.)--University of Alabama at Birmingham, 2008.<br>Additional advisors: Paul D. Blanton, David G. Clark, Roy C. Martin, Virginia G. Wadley. Description based on contents viewed Feb. 9, 2009; title from PDF t.p. Includes bibliographical references (p. 63-76).

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2

Thompson, Juliann. "Sex Differences in Cognitive Decline in Mild Cognitive Impairment and Alzheimer's Disease." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6412.

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Alzheimer's disease (AD) is the most common form of dementia and results in progressive cognitive decline, particularly in regards to memory (National Institute on Aging, 2012). Prior research has shown sex differences in brain-atrophy rates of AD patients, with women experiencing a higher rate of progression in volume reduction (Skup et al., 2011). This suggests that there may also be differences in cognitive functioning between sexes, particularly in the rate of cognitive decline with a more rapid disease progression for dementing females compared to dementing males. The current study monito

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3

Khan, Wasim Nawaz. "Neuroimaging markers of Alzheimer's disease, mild cognitive impairment and normal healthy ageing." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/neuroimaging-markers-of-alzheimers-disease-mild-cognitive-impairment-and-normal-healthy-ageing(c507bdb2-721c-4060-8a06-9f01b39d3de1).html.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder clinically characterised by memory loss and cognitive decline that severely affect activities of daily living. Neuropathologically, the disease is characterised by two major proteinopathies, extracellular amyloid-beta (Aβ) plaques and intraneuronal neurofibrillary tangle pathology. The development of neuroimaging biomarkers for AD have transformed the assessment of brain changes associated with these pathological processes for the earlier detection of AD. However, additional work is needed to validate more robust neuroimaging

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4

Van, Adel J. Michael. "Prospective Memory Abilities In Aging and Mild Cognitive Impairment/ Early Alzheimer’s Disease." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35327.

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This dissertation describes separate but related studies that explore the prospective memory abilities of older adults and individuals with Mild Cognitive Impairment/Early Alzheimer’s disease. Prospective memory (PM) refers to the type of memory utilized to execute planned actions in accordance with a specific event. PM is critical to maintaining functional independence in older adults, as it can refer to such basic acts as remembering to turn off a stove or taking one’s medication. Research suggests PM abilities decline within normal aging and to a greater extent in Mild Cognitive Impairment

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5

Okello, Aren Atiti. "PET studies on disease progression and treatment efficacy in Alzheimer's disease and mild cognitive impairment." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/7110.

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Alzheimer’s disease (AD) is the most common cause of dementia. Mild cognitive impairment (MCI) is a transitional state between normal ageing and dementia. Positron emission tomography (PET) can detect the metabolic and neuro-chemical changes that occur in MCI and dementia. The aim of this thesis was to assess the use of PET as an in vivo biomarker for early disease detection, prognosis, and proof of treatment efficacy in AD and MCI. In study I, the prevalence of increased beta-amyloid deposition (assessed by 11C-PIB PET) and microglial activation (assessed by 11C-PK11195 PET) was studied in am

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6

Ramakers, Inez Hubertina Gertruda Bernard. "Prodromal Alzheimer's disease in subjects with Mild Cognitive Impairment predictive and diagnostic aspects." Maastricht : Maastricht : NeuroPsych Publishers ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=13926.

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7

Grönholm-Nyman, Petra. "Verbal learning in mild cognitive impairment and Alzheimer's disease : behavioural and neural approaches /." Åbo : Åbo Akademi University, 2009. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=018662159&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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8

Bush, Aryn L. H. "Effects of mild cognitive impairment on visual world recognition a longitudinal investigation /." Akron, OH : University of Akron, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1144771075.

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Dissertation (Ph. D.)--University of Akron, Dept. of Psychology, 2006.<br>"May, 2006." Title from electronic dissertation title page (viewed 09/16/2006) Advisor, Philip A. Allen; Committee members, Kevin P. Kaut, Martin D. Murphy, Raymond E. Sanders, Daniel L. Ely; Department Chair, Paul E. Levy; Dean of the College, Ronald F. Levant; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.

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9

Kalbe, Elke, Eric Salmon, Daniela Perani, et al. "Anosognosia in Very Mild Alzheimer’s Disease but Not in Mild Cognitive Impairment." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135834.

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Objective: To study awareness of cognitive dysfunction in patients with very mild Alzheimer’s disease (AD) and subjects with mild cognitive impairment (MCI). Methods: A complaint interview covering 13 cognitive domains was administered to 82 AD and 79 MCI patients and their caregivers. The patient groups were comparable according to age and education, and Mini Mental State Examination (MMSE) scores were ≥24 in all cases. The discrepancy between the patients’ and caregivers’ estimations of impairments was taken as a measure of anosognosia. Results: Self-reports of cognitive difficulties were co

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10

Kalbe, Elke, Eric Salmon, Daniela Perani, et al. "Anosognosia in Very Mild Alzheimer’s Disease but Not in Mild Cognitive Impairment." Karger, 2005. https://tud.qucosa.de/id/qucosa%3A27681.

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Objective: To study awareness of cognitive dysfunction in patients with very mild Alzheimer’s disease (AD) and subjects with mild cognitive impairment (MCI). Methods: A complaint interview covering 13 cognitive domains was administered to 82 AD and 79 MCI patients and their caregivers. The patient groups were comparable according to age and education, and Mini Mental State Examination (MMSE) scores were ≥24 in all cases. The discrepancy between the patients’ and caregivers’ estimations of impairments was taken as a measure of anosognosia. Results: Self-reports of cognitive difficulties were co

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11

Rowley, Jared. "White matter abnormailities and structural hippocampal disconnections in Alzheimer's disease and amnestic mild cognitive impairment." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116922.

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Objective: The purpose of this project was to evaluate white matter degeneration and its impact on hippocampal structural connectivity in patients with amnestic mild cognitive impairment, non-amnestic mild cognitive impairment and Alzheimer's disease.Methods: We estimated white matter fractional anisotropy, mean diffusivity and hippocampal structural connectivity in two independent cohorts. The ADNI cohort included 108 subjects [25 cognitively normal, 21 amnestic mild cognitive impairment, 47 non-amnestic mild cognitive impairment and 15 Alzheimer's disease]. A second cohort included 34 subjec

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12

Bauer, Corinna Mae. "Multimodal analysis in normal aging, mild cognitive impairment, and Alzheimer's disease: group differentiation, baseline cognition, and prediction of future cognitive decline." Thesis, Boston University, 2013. https://hdl.handle.net/2144/10937.

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Thesis (Ph.D.)--Boston University<br>Alzheimer's disease (AD) is a progressive neurodegenerative disease with an insidious onset that makes it difficult to distinguish from normal aging. It begins with an impairment of memory that develops into amnestic mild cognitive impairment (aMCI) and later to dementia as deficits become apparent in other cognitive domains. Effective biomarkers that differentiate normal aging, MCI, and AD and predict future cognitive decline are needed. Potential biomarkers have been studied in isolation, but their impact when combined is not understood. The goal of this

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13

Daneshvar, Daniel H. "An apolipoprotein-E mediated relationship between smoking and risk of mild cognitive impairment and Alzheimer's disease." Thesis, Boston University, 2007. https://hdl.handle.net/2144/38021.

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Thesis (M.A.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Increasing evidence indicates that the sooner treatment begins for patients with Alzheimer's Disease (AD), the better the chance of delaying progression of the disease. As a result, studies have begun focusing

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14

Mullan, Gemma. "The role of Clusterin/apolipoprotein J and HDL functionality in Alzheimer's disease and mild cognitive impairment." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680063.

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The CLU gene is associated with Alzheimer's disease (AD). With its protein, clusterin, having the ability to bind to various ligands, such as amyloid beta, thus it has become a worthy target in AD research Therefore, the focus of this thesis was to investigate the implications of clusterin within mild cognitive impairment (MCI) and AD. Aims and Objectives This thesis encompassed four main studies. The first investigated if SNP rs11136000 influenced plasma clusterin in MCI and AD, compared to an age-matched cognitively healthy control group. The second study assessed if plasma soluble receptors

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15

Karrasch, Mira. "Normal aging, mild cognitive impairment and Alzheimer's disease : neuropsychological screening and electrophysiological correlates of working memory /." Åbo : Åbo akademi university, 2005. http://catalogue.bnf.fr/ark:/12148/cb40223492j.

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16

Redel, Petra. "Visual attentional assessment in mild cognitive impairment and Alzheimer's disease based on a theory of visual attention." kostenfrei, 2009. http://d-nb.info/1000553817/34.

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17

Adler, Claudia. "Specific memory complaints and the identification of preclinical Alzheimer's disease years before conversion to Mild Cognitive Impairment." Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/315821.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Early detection of cognitive decline will become increasingly important as preventative therapies for Alzheimer’s disease (AD) become available. While new imaging techniques and biomarkers have shown evidence of neuropathology in the preclinical stages of AD, most clinicians must rely on the subjective report of symptoms to identify the onset of cognitive decline. Patients often present to primary care physicians with complaints from

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18

Huang, Chaorui. "Mild cognitive impairment : neuroimaging markers for early diagnosis of dementia /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-633-2/.

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19

Kjelvik, Grete. "Human odor identification studied in healthy individuals, mild cognitive impairment and Alzheimer’s disease." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for sirkulasjon og bildediagnostikk, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-19492.

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Evnen til å identifisere lukter studert hos friske individer, personer med mild kognitiv svikt og Alzheimers sykdom Bakgrunn: Luktidentifikasjon er evnen til å oppfatte og navngi en lukt riktig. Allerede i midten av 1970-årene ble de første studiene publisert som viste at evnen til å lukte er svekket ved nevrodegenerative sykdommer (Ansari og Johnson og Waldton). Majoriteten av pasienter med amnestisk mild kognitiv svikt (aMCI) og tidlig Alzheimers sykdom er vist å få redusert lukteevnen, særskilt evnen til å identifisere lukter. Siden områder i hjernens temporallapp er sentral både i luktpros

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20

Long, Xiaojing. "Image Classification using Pair-wise Registration and Machine Learning with Applications to Neuroimaging." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/40396.

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Alzheimer's disease~(AD) is the most frequent neurodegenerative dementia and a growing health problem. Early and accurate diagnosis and prediction of AD is crucial because treatment may be most efficacious if introduced as early as possible. Neuropsychological testing, which is clinically used, sometimes fails to recognize probable dementia, especially to recognize the disease at an early time point such as the mild cognitive impairment~(MCI), which is the prodromal stage of AD. Recently, there has been a realization that magnetic resonance imaging~(MRI) may help diagnoses of AD and MCI. In t

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21

Coltman, Robin Bruce. "Characterisation of a mouse model of chronic cerebral hypoperfusion and its application to investigating the impact of hypoperfusion on the development of Alzheimer's disease." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6518.

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The integrity of brain white matter is vital for the interneuronal signalling between distinct brain regions required for normal cognitive function. White matter integrity is compromised with ageing and could contribute to age-related cognitive decline. Chronic cerebral hypoperfusion is thought to underlie the development of white matter pathology and cognitive changes, often seen in the elderly. Additionally, the development of regional hypoperfusion and white matter damage are thought to be early events in Alzheimer’s disease (AD) pathogenesis. This thesis set out to test the hypothesis that

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22

Friedl, Wendel Matthew. "Dissociating Alzheimer’s Disease from Amnestic Mild Cognitive Impairment using Time-Frequency Based EEG Neurometrics." W&M ScholarWorks, 2018. https://scholarworks.wm.edu/etd/1530192710.

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This work explores the utility of using magnitude (ERSP), phase angle (ITPC), and cross-frequency coupling (PAC) indices derived from electroencephalogram (EEG) recording using spectral decomposition as unique biomarkers of Alzheimer’s Disease (AD) and amnestic mild cognitive impairment (aMCI), respectively. The experimental protocol was a visual oddball discrimination task conducted during a brief (approximately 20 minute) recording session. Participants were 60 older adults from an outpatient memory clinic diagnosed with either aMCI (n=29; M=73.0; SD=9.32) or AD (n=31; M=78.29; SD=8.28) acco

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23

Francois, Maxime. "Discovery of new biomarkers of mild cognitive impairment and Alzheimer's disease risk in buccal cells using laser scanning cytometry." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2013. https://ro.ecu.edu.au/theses/567.

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Previous studies have shown that mild cognitive impairment (MCI) may reflect the early stages of more pronounced neurodegenerative disorders such as Alzheimer’s disease (AD). In clinical practice, patients with AD are not usually identified until the disease has progressed to a stage when primary prevention is no longer possible. Therefore there is a need for a minimally invasive and inexpensive diagnostic to identify those who exhibit cellular pathology indicative of MCI and AD risk so that they can be prioritised for primary prevention. Human buccal cells are accessible in a minimally invasi

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Cunningham, Emily Christine. "Evaluation of a Brief Neurometric Battery for the Detection of Neurocognitive Changes Associated with Amnestic Mild Cognitive Impairment and Probable Alzheimer's Disease." W&M ScholarWorks, 2015. https://scholarworks.wm.edu/etd/1539626812.

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25

Wang, Jianquan. "Increased oxidative damage to DNA and the effects on mitochondrial protein in Alzheimer's disease." Lexington, Ky. : [University of Kentucky Libraries], 2006. http://lib.uky.edu/ETD/ukychem2006d00533/jwangETD.pdf.

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Thesis (Ph. D.)--University of Kentucky, 2006.<br>Title from document title page (viewed on January 23, 2007). Document formatted into pages; contains: ix, 141 p. : ill. (some col.). Includes abstract and vita. Includes bibliographical references (p. 118-139).

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26

Harrison, Bush Aryn Lyn. "Effects of Mild Cognitive Impairment on Visual Word Recognition: A Longitudinal Investigation." University of Akron / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=akron1144771075.

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27

Anna, Canal Garcia. "Study of brain imaging correlates of Mild Cognitive Impairment and Alzheimer’s Disease with machine learning." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-251502.

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Accurate diagnosis in the early stages is an important challenge for the prevention and effective treatment of Alzheimer’s Disease (AD). This work proposes a method of analysis of the correlation of Mild Cognitive Impairment (MCI) subtypes and its progression to AD using neuroimages such as structural magnetic resonance imaging (MRI) scans. Basic data pre-processing such as the extraction of brain-tissue related parts of the image, image registration and standardization to the mean and deviation is applied. A convolutional autoencoder (CAE) is used to reduce data dimensionality and learn gener

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PICCO, AGNESE. "Biomarkers validation in Alzheimer’s Disease and related pathologies." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/1008117.

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The aim of this research project was to investigate biomarkers of Alzheimer’s disease (AD) and related pathologies. The future of these biomarkers relies in their proper validation in all settings (analytical and clinical). In the first two papers, I cooperated with a task force of expert in AD and oncology field, who adapted a framework for biomarkers development used in oncology to AD. We assessed existing evidence based on this framework for amyloid-PET; CSF Abeta42, tau/phospho-tau; FDG-PET; hippocampal atrophy, 123I-Ioflupane, 123I-MIBG, and neuropsychology. Then, I focused my PhD proj

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Annerbo, Sylvia. "Development of dementia in mild cognitive impairment (MCI) patients with focus on B-vitamins /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-223-1/.

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Wu-Puigbo, Ya-Huei. "Validation d'un test de barrage informatisé sur tablette évaluant les fonctions exécutives auprès d'une population gériatrique." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB210/document.

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Dans le contexte du diagnostic précoce de la maladie d’Alzheimer, une direction de la recherche émerge autour de l’informatisation de tests cognitifs. Nous avons conçu un test de barrage informatisé sur tablette (test e-CT), développé à partir d’un test de barrage papier-crayon. Nous avons étudié les variables influençant les performances au test e-CT et ses propriétés psychométriques. Nous avons observé que chez les sujets âgés sains, la seule variable influençant était l’âge. Les performances au test e-CT n’étaient pas influencées par l’expérience avec un appareil informatique. Cependant, ch

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31

Arnaiz, Lanzo Eva. "Predictors of Alzheimer's Disease in subjects with mild Cognitive Impairment. Focus on neuropsychology in relation to genetic and neuroimaging markers." Doctoral thesis, Universitat Autònoma de Barcelona, 2001. http://hdl.handle.net/10803/3728.

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El Deterioro Cognitivo Leve (DCL) es un término operacional en relación a aquéllos déficits cognitivos que están presentes en sujetos sin un deterioro funcional significativo y que no satisfacen los criterios clínicos establecidos para una demencia. El concepto DCL tiene la ventaja de proveer una entidad diagnóstica para aquellos individuos que en un gran porcentaje desarrollaran una demencia. Ya que el DCL padece un deterioro cognitivo detectable objectivamente antes de la aparición clínica de la demencia, es importante mejorara las herramientas de diagnósticos tales como las baterías de scre

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Vannini, Patrizia. "Functional neurobiology in normal aging, mild cognitive impairment and Alzheimer's disease : focus on visuospatial processing using functional magnetic resonance imaging /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-164-7/.

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33

Boespflug, Erin L. "Component diffusion tensor analysis suggests disparate temporal stem and fornix white matter pathology in Mild Cognitive Impairment." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1336137888.

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34

Morrow, Luzviminda Salamat. "Effectiveness of Cognitive Rehabilitation as Memory Intervention for Elderly Adults with Dementia." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/4314.

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Although cognitive rehabilitation is not a new field of intervention, as it dates back to the treatment of brain-injured soldiers during World War I, the use of cognitive rehabilitation intervention therapies for individuals with dementia and mild cognitive impairment has yet to draw definite conclusions about its effectiveness. Based on the conceptual framework of biopsychosocial theoretical model, this study explored to what extend cognitive rehabilitation intervention was effective in improving the memory and mood functioning of elderly adults with mild cognitive impairments. An archived da

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Djabelkhir, Jemmi Leila. "Prise en charge non pharmacologique des troubles cognitifs légers : effets différentiels d'un programme de stimulation cognitive informatisée selon la sévérité des hypersignaux de la substance blanche de patients MCI." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB241.

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Les hypersignaux de la substance blanche (HSB) ont été associés à des déficits exécutifs et mnésiques et à une atteinte des circuits corticaux et sous-corticaux frontaux. Leur présence, en plus du dépôt ß-amyloïde chez de nombreux patients avec un MCI (Mild Cognitive Impairment ou trouble cognitif léger) augmenterait le risque de conversion vers une maladie d'Alzheimer (MA). Un des enjeux importants dans la phase préclinique de la maladie est d'explorer le potentiel des interventions cognitives pour prévenir le déclin cognitif et la progression vers une MA. Alors que les HSB sont de plus en pl

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Yang, Yan. "Predicting Conversion from Mild Cognitive Impairment to Alzheimer’s Disease using Partially Ordered Models of Neuopsychological Measurements." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1310137640.

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Kreutz, Marianne. "Performance of people with mild cognitive impairment or early Alzheimer's disease on the behavioural assessment of the dysexecutive syndrome test battery." Thesis, University of Hertfordshire, 2004. http://hdl.handle.net/2299/14237.

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Aim: Decline in executive functioning in Mild Cognitive Impairment has only been investigated with single tests to date. A battery of executive function tasks (BADS: Behavioural Assessment of the Dysexecutive Syndrome) was used to investigate and compare the extent of executive function difficulties in people with Mild Cognitive Impairment and early Alzheimer Disease. Degree and prevalence of decline were examined for each of the groups, and performance patterns compared between the two groups. Participants: 37 Participants (19 MCI, 18 early AD) were recruited from one urban, one suburban and

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Zamboni, Giovanna. "Structural and functional magnetic resonance imaging (MRI) in the prediction and characterization of mild cognitive impairment (MCI) and Alzheimer's disease (AD)." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:8cdd8320-1243-4f85-928c-b03fd4bd1201.

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The aim of the research presented in this thesis was to improve the characterisation of the changes in brain structure and function that occur at different stages of Alzheimer’s disease (AD) progression, from pre-symptomatic AD, to mild cognitive impairment (MCI), to clinically evident dementia, using magnetic resonance imaging (MRI) techniques. Baseline structural MRI data from a cohort of healthy older adults who were followed prospectively for ten years, during which time some developed MCI and some AD, were analysed. It was found that structural MRI could detect volume loss in medial-tempo

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Bubu, Omonigho A. Michael. "Sleep and Alzheimer’s disease: A critical examination of the risk that Sleep Problems or Disorders particularly Obstructive Sleep Apnea pose towards developing Alzheimer’s disease." Scholar Commons, 2017. https://scholarcommons.usf.edu/etd/7394.

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This dissertation is a critical examination of the relationship between sleep problems and/or disorders, particularly Obstructive Sleep Apnea (OSA) and Alzheimer Disease (AD). First, I conducted an exhaustive systematic review of existing literature, and identified gaps in research that led to specific research aims. For the first aim, I conducted the first ever-published meta-analysis examining sleep, cognitive decline and AD, providing an aggregate effect of sleep on AD. Second, focusing on OSA, I conducted a study examining OSA’s effect on longitudinal changes on AD biom

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Cornett, Patricia F. Hall James. "Factors of the geriatric depression scale that may distinguish between four cognitive diagnostic groups normal, mild cognitive impairment, dementia of the Alzheimer's type, and vascular dementia /." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/ark:/67531/metadc12105.

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Forsström, Karin. "Longitudinal Changes in Astroglial and Inflammatory Markers in Patients with MCI and AD." Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-192975.

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Since neuroinflammation is present in patients with mild cognitive impairment (MCI) andAlzheimer's disease (AD) and since cholinesterase inhibitors increases the level ofacetylcholine, the aim was to investigate whether inflammatory markers of cholinoceptive cellsare affected in these patients. Near a biological hallmark of AD, amyloid plaque, activatedastrocytes and microglia can be found and higher levels of proinflammatory cytokines, i.e. IL-1β. To study the inflammatory response, proteins GFAP and S100B are used as CSF glialmarkers. IL-1β can bind to the membrane-bound IL-1 receptor or sol

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Marlats, Fabienne. "Effets différentiels d'un entraînement neurofeedback électroencéphalographique auprès de personnes âgées avec MCI EEG neurofeedback training in elderly with mild cognitive impairment: A feasibility study SMR/theta neurofeedback training improves cognitive performance and EEG activity in elderly with mild cognitive impairment: A pilot study Comparison of effects between SMR/delta-ratio and beta1/theta-ratio neurofeedback training for older adults with mild cognitive impairment: a protocol for a randomized controlled trial." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCB045.

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Le neurofeedback électroencéphalographique ( NF EEG) est une technique d'apprentissage de l'auto-régulation de l'activité électrique cérébrale. Un patient reçoit des informations sur son activité cérébrale en temps réel qu'il peut modifier grâce à la mobilisation de capacités attentionnelles et d'un certain état de vigilance. Les études portant sur les effets du NF sur les troubles cognitifs liés au vieillissement sont récentes. Le champ d'application du NF en gérontologie se développe rapidement auprès des personnes avec troubles cognitifs légers (ou Mild Cognitive Impairment-MCI) et avec la

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Anjum, Ayesha. "Differentiation of alzheimer's disease dementia, mild cognitive impairment and normal condition using PET-FDG and AV-45 imaging : a machine-learning approach." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2238/.

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Nous avons utilisé l'imagerie TEP avec les traceurs F18-FDG et AV45 en conjonction avec les méthodes de classification du domaine du "Machine Learning". Les images ont été acquises en mode dynamique, une image toutes les 5 minutes. Les données ont été transformées par Analyse en Composantes Principales et Analyse en Composantes Indépendantes. Les images proviennent de trois sources différentes: la base de données ADNI (Alzheimer's Disease Neuroimaging Initiative) et deux protocoles réalisés au sein du centre TEP de l'hôpital Purpan. Pour évaluer la performance de la classification nous avons e

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Redel, Petra. "Visual attentional assessment in mild cognitive impairment and Alzheimer’s disease based on a theory of visual attention." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-111198.

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Emmett, Catherine Parsons. "Exploring the Advance Care Planning Experiences among Persons with Mild Cognitive Impairment: Individual and Spousal Perspectives." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4313.

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Advance Care Planning has been advocated for over 20 years as a way in which individuals who are no longer able to speak for themselves, may still convey their preferences regarding a wide of array of decisions, including medical care. Advance care planning may not be initiated by individuals for many reasons, and even when initiated, may not be specific enough to help guide decision making. Recent advance care planning models have utilized disease specific information to help guide end of life health care decision-making. Persons diagnosed with mild cognitive impairment face an increased p

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Goh, Jeremy Jao Yang. "Parkinson's Disease: Structural Integrity of Four Cognitive Networks." Thesis, University of Canterbury. Department of Psychology, 2013. http://hdl.handle.net/10092/8982.

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Individuals with Parkinson’s disease (PD) often show cognitive impairments in addition to motor symptoms, with the majority of PD patients converting to dementia as the disease progresses. The changes in the microstructural integrity of key nodes in resting state networks (RSNs) could be a good indicator of the cognitive effects of PD on brain regions as it progresses to dementia. To assess the association between cognitive effects and microstructural change, the microstructural integrity of the regions of interest (ROIs) in 4 resting state networks (RSN), specifically the default mode network

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Serrao, Valeria Trunkl. "Desempenho de uma amostra de indivíduos com comprometimento cognitivo leve, doença de Alzheimer e idosos saudáveis em tarefa de decisão lexical." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-11012016-151041/.

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Introdução: As tarefas de decisão lexical possibilitam estimar o funcionamento cognitivo ou QI pré-mórbido e através desta estimativa, podese estabelecer se houve estabilidade ou declínio em relação ao funcionamento pregresso do sujeito. Considerando o rápido envelhecimento da população idosa e as doenças neurodegenerativas associadas, fazer o diagnóstico precoce destas se torna cada vez mais imperioso. Embora a avaliação do QI pré-mórbido seja fundamental para o mapeamento do funcionamento cognitivo global prévio, não há estudos na população brasileira que utilizaram tarefas de decisão lexica

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48

Godinho, Claudia da Cunha. "Incidência de demência e comprometimento cognitivo leve e identificação de preditores numa amostra de base populacional." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/67526.

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Introdução: Com o envelhecimento da população mundial projeta-se o crescimento das taxas de doenças potencialmente relacionadas à idade como as demências, especialmente a doença de Alzheimer (DA). Os sujeitos com Comprometimento Cognitivo Leve (CCL) são considerados uma população de risco para desenvolver demência, no entanto, as taxas de incidência de CCL e conversão para demência apresentam considerável variabilidade em parte atribuída a características da amostra e aos diferentes critérios utilizados. Objetivos: Determinar a incidência de demência e Comprometimento Cognitivo Leve em uma coo

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Ngandu, Tiia. "Lifestyle-related risk factors in dementia and mild cognitive impairment : a population-based study /." Stockholm : Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2006. http://diss.kib.ki.se/2006/91-7140-744-8/.

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Cornett, Patricia F. "Factors of the Geriatric Depression Scale that may Distinguish between Four Cognitive Diagnostic Groups: Normal, Mild Cognitive Impairment, Dementia of the Alzheimer's Type, and Vascular Dementia." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc12105/.

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The purpose of the current study was to explore the relationship between cognitive status and depression in a sample of geriatric patients. Participants included 282 geriatric patients ranging in age from 65 to 96 years who were classified according to diagnosis as: DAT, VaD, MCI, and Norm. All were referred for neurocognitive testing from the Geriatric Assessment Program (GAP) at the University of North Texas Health Science Center (UNTHSC) in Fort Worth, Texas. This study sought to identify factor structures for two versions of the GDS using a geriatric sample of cognitively impaired and inta

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