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Journal articles on the topic 'Minimally invasive glaucoma surgery (MIGS)'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Maheshwari, Devendra, Harinikrishna Balakrishnan, Mohideen A. Kader, and Ramakrishnan Rengappa. "Minimally Invasive Glaucoma Surgery—A Comprehensive Review." TNOA Journal of Ophthalmic Science and Research 63, no. 2 (2025): 160–66. https://doi.org/10.4103/tjosr.tjosr_47_25.

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Glaucoma is a progressive and irreversible optic neuropathy that can lead to blindness if left untreated, with intraocular pressure (IOP) being the primary modifiable risk factor. Minimally invasive glaucoma surgery (MIGS) refers to a set of procedures designed to lower IOP with minimal disruption to normal eye anatomy, offering a high level of safety, efficacy and fast recovery. While glaucoma is initially treated with medications, patients who do not respond to medical or laser treatments often require surgical intervention. Traditional surgeries like trabeculectomy and tube shunts, although

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Jónsson, Davíð Þór, Ólöf Birna Ólafsdóttir, and María Soffía Gottfreðsdóttir. "Visual field loss in eyes undergoing minimally invasive glaucoma surgery in Iceland." Læknablaðið 108, no. 12 (2022): 547–51. http://dx.doi.org/10.17992/lbl.2022.12.720.

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INTRODUCTION: Glaucoma is a degenerative disease of the optic nerve and is marked by visual field defects (VFD). The only approved treatment is IOP lowering, either with eye drops, laser or surgery. Minimally invasive glaucoma surgery (MIGS) has become an appealing treatment modality, offering IOP lowering effect without the complication rates of trabeculectomy or the patient adherence required for pharmacologic therapy. In this study we aim to describe the severity of VFD in patients undergoing their first MIGS surgery. METHODS: Retrospective study reviewing the medical records of all patient

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Balas, Michael, and David J. Mathew. "Minimally Invasive Glaucoma Surgery: A Review of the Literature." Vision 7, no. 3 (2023): 54. http://dx.doi.org/10.3390/vision7030054.

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Minimally invasive glaucoma surgery (MIGS) has emerged as a novel approach in the glaucoma treatment spectrum, offering a range of diverse procedures and devices aimed at reducing intraocular pressure (IOP). MIGS can be broadly classified into several categories: those that enhance trabecular outflow (Trabectome, iStent, Hydrus Microstent, Kahook Dual Blade, high frequency deep sclerotomy, and gonioscopy-assisted transluminal trabeculotomy), those that augment suprachoroidal outflow (CyPass Microstent and iStent Supra), those that target Schlemm’s canal (TRAB360 and the OMNI Surgical System, S

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Pożarowska, Dorota, and Tomasz Żarnowski. "Minimally invasive glaucoma surgery (MIGS): XEN implant." OphthaTherapy. Therapies in Ophthalmology 6, no. 1 (2019): 18–23. http://dx.doi.org/10.24292/01.ot.300319.03.

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Brandão, Lívia M., and Matthias C. Grieshaber. "Update on Minimally Invasive Glaucoma Surgery (MIGS) and New Implants." Journal of Ophthalmology 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/705915.

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Traditional glaucoma surgery has been challenged by the advent of innovative techniques and new implants in the past few years. There is an increasing demand for safer glaucoma surgery offering patients a timely surgical solution in reducing intraocular pressure (IOP) and improving their quality of life. The new procedures and devices aim to lower IOP with a higher safety profile than fistulating surgery (trabeculectomy/drainage tubes) and are collectively termed “minimally invasive glaucoma surgery (MIGS).” The main advantage of MIGS is that they are nonpenetrating and/or bleb-independent pro

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Mathew, David J., and Yvonne M. Buys. "Minimally Invasive Glaucoma Surgery: A Critical Appraisal of the Literature." Annual Review of Vision Science 6, no. 1 (2020): 47–89. http://dx.doi.org/10.1146/annurev-vision-121219-081737.

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Micro- or minimally invasive glaucoma surgeries (MIGS) have been the latest addition to the glaucoma surgical treatment paradigm. This term refers not to a single surgery, but rather to a group of distinct procedures and devices that aim to decrease intraocular pressure. Broadly, MIGS can be categorized into surgeries that increase the trabecular outflow [Trabectome, iStent (first and second generations), Hydrus microstent, Kahook Dual Blade and gonioscopy-assisted transluminal trabeculotomy], surgeries that increase suprachoroidal outflow (Cypass microstent and iStent Supra), and conjunctival

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Ranovian, Ridho, and Widya Artini Sumantri. "MINIMALLY INVASIVE GLAUCOMA SURGERY (MIGS): COMPARISON OF TRABECULAR VERSUS SUPRACHOROIDAL ROUTE." Ophthalmologica Indonesiana 49, no. 1 (2023): 85–98. http://dx.doi.org/10.35749/journal.v49i1.100707.

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Introduction: Because of the high rate of complications associated with traditional glaucoma filtering surgery, various research were launched to develop a new device, such as drainage channels, such as Glaucoma Drainage Devices. Objective: To compare the efficacy and safety of trabecular route and suprachoroidal MIGS in eyes with mild to moderate glaucoma with and without cataract extraction of these two devices. Methods: Literature search was conducted using online database such as Google Scholar, Pubmed, Survey of Ophtalmology, and Clinical Key. Result: Since the IOP-lowering efficacy of th

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Rowson, Antonia C., Daniel T. Hogarty, Dominic Maher, and Lei Liu. "Minimally Invasive Glaucoma Surgery: Safety of Individual Devices." Journal of Clinical Medicine 11, no. 22 (2022): 6833. http://dx.doi.org/10.3390/jcm11226833.

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Primary open-angle glaucoma progression in those already on maximal medical therapy has traditionally been treated with trabeculectomy, a surgical procedure that carries a high degree of morbidity. In the last few decades, significant advances have been made in the field of minimally invasive glaucoma surgery (MIGS) devices, which aim to defer or prevent trabeculectomy via less arduous surgical techniques in certain types of glaucoma. Although reviews have been published examining the efficacy of various MIGS techniques, no article synthesises the comparative safety of all available devices. W

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Hayakawa, Yasunari, and Takayuki Inada. "Background of Minimally Invasive Glaucoma Surgery (MIGS)-Adapted Patients for Cataract Surgery in Glaucoma." Journal of Clinical Medicine 13, no. 18 (2024): 5378. http://dx.doi.org/10.3390/jcm13185378.

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Purpose: To investigate whether it is better to perform minimally invasive glaucoma surgery (MIGS) when performing cataract surgery on glaucoma patients. Methods: The study enrolled a total of 159 eyes of subjects with mild-to-moderate glaucoma, including primary open angle glaucoma (POAG), normal tension glaucoma (NTG), and combined mechanism glaucoma (CMG) with visually significant cataract, who were treated with one or more ophthalmic antiglaucoma agents. Phacoemulsification and aspiration with intraocular lens insertion (PEA + IOL, phaco group) or MIGS with PEA + IOL (µLot-phaco group) was

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Jones, Lee, Natalia Maes, Umair Qidwai, and Gokulan Ratnarajan. "Impact of minimally invasive glaucoma surgery on the ocular surface and quality of life in patients with glaucoma." Therapeutic Advances in Ophthalmology 15 (January 2023): 251584142311527. http://dx.doi.org/10.1177/25158414231152765.

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Background: Minimally invasive glaucoma procedures are emerging as clinically effective and safe glaucoma management approaches; however, evidence regarding quality-of-life outcomes is limited. Objectives: To explore the impact of minimally invasive glaucoma surgery (MIGS) combined with phacoemulsification on patient-reported outcomes and clinical parameters related to ocular surface disease in people with glaucoma. Design: Retrospective observational study. Methods: Fifty-seven consecutive patients were examined prior to undergoing iStent combined with phacoemulsification with or without adju

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Saeed, Emil, Kinga Gołaszewska, Diana Anna Dmuchowska, Renata Zalewska, and Joanna Konopińska. "The PreserFlo MicroShunt in the Context of Minimally Invasive Glaucoma Surgery: A Narrative Review." International Journal of Environmental Research and Public Health 20, no. 4 (2023): 2904. http://dx.doi.org/10.3390/ijerph20042904.

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Recently, the quest for novel glaucoma surgical techniques and devices has been underway. Trabeculectomy remains the gold standard, but it requires the implantation of glaucoma drainage devices and frequent follow-ups, and it also carries a high risk of serious complications. The need for less invasive and safer procedures has led to the development of minimally invasive glaucoma surgery (MIGS), particularly for patients with mild–to–moderate disease. Among them, minimally invasive bleb surgery seems to be effective in classical glaucoma surgery, while maintaining MIGS benefits. The relatively

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Movsisyan, A. B., A. E. Egorov, and A. V. Kuroyedov. "Effectiveness of minimally invasive glaucoma surgery (review of international experience)." National Journal glaucoma 21, no. 4 (2022): 56–63. http://dx.doi.org/10.53432/2078-4104-2022-21-4-56-63.

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The trends of recent years regarding the surgical treatment of the visual organ and its appendages are to minimize tissue traumatization during surgical manipulations, reduce their duration, as well as achieve the best possible outcome from the points of view of the doctor and the patient at minimal economic costs. Currently, the leading vector in glaucoma treatment remains the achievement of the target level of intraocular pressure (IOP). Taking into account the projected increase in the number of patients with glaucoma, conducting justified surgical treatment will remain relevant in the futu

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Siewert, Stefan, Wolfram Schmidt, Sebastian Kaule, et al. "Development of a microstent system for minimally invasive glaucoma surgery." Current Directions in Biomedical Engineering 3, no. 2 (2017): 779–81. http://dx.doi.org/10.1515/cdbme-2017-0164.

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AbstractGlaucoma is the leading cause of irreversible blindness worldwide. An increased intraocular pressure (IOP) is known as major risk factor. Currently, drainage devices that are implanted by means of minimally invasive glaucoma surgery (MIGS) represent a promising approach for IOP low-ering. Commercially available devices for MIGS suffer from unregulated drainage involving ocular hypotony. Further-more, long term drainage capability of current devices is limited by fibrotic encapsulation processes. Therefore, our group focusses on the development of a valved drug-eluting microstent for MI

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14

Peng, Chuzhi, Hongyan Jia, Jianping Hu, and Yonghong Jiao. "Characteristics and publication status of minimally invasive glaucoma surgery trials registered in ClinicalTrials.gov, 2007–2024: a cross-sectional study." BMJ Open 15, no. 1 (2025): e095854. https://doi.org/10.1136/bmjopen-2024-095854.

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Purpose To investigate the characteristics and publication status of minimally invasive glaucoma surgery (MIGS) clinical trials registered on ClinicalTrials.gov. Design A cross-sectional study. Methods All 1212 interventional glaucoma trials registered on ClinicalTrials.gov with start dates between 1 October 2007 and 30 April 2024 were included. All trials were categorised into ‘MIGS trials’ and ‘other interventional glaucoma trials’. Based on the anatomical site of action and the research content, MIGS trials were classified into different groups, and intergroup comparisons were conducted. Th

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Ansari, Ejaz. "An Update on Implants for Minimally Invasive Glaucoma Surgery (MIGS)." Ophthalmology and Therapy 6, no. 2 (2017): 233–41. http://dx.doi.org/10.1007/s40123-017-0098-2.

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Ang, Bryan Chin Hou, Sheng Yang Lim, Bjorn Kaijun Betzler, Hon Jen Wong, Michael W. Stewart, and Syril Dorairaj. "Recent Advancements in Glaucoma Surgery—A Review." Bioengineering 10, no. 9 (2023): 1096. http://dx.doi.org/10.3390/bioengineering10091096.

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Surgery has long been an important treatment for limiting optic nerve damage and minimising visual loss in patients with glaucoma. Numerous improvements, modifications, and innovations in glaucoma surgery over recent decades have improved surgical safety, and have led to earlier and more frequent surgical intervention in glaucoma patients at risk of vision loss. This review summarises the latest advancements in trabeculectomy surgery, glaucoma drainage device (GDD) implantation, and minimally invasive glaucoma surgery (MIGS). A comprehensive search of MEDLINE, EMBASE, and CENTRAL databases, al

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17

Feijoo, J. Garcia. "Bleb-less Surgery and Phaco – the iStent Saga." European Ophthalmic Review 08, no. 02 (2014): 104. http://dx.doi.org/10.17925/eor.2014.08.02.104.

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In the past years there is been a rapid evolution of cataract surgery; however, in glaucoma filtration surgery is still the gold standard. New techniques and devices have been developed and may change the surgical algorithm. Minimally invasive glaucoma surgery (MIGS) is safe, can be performed abinternothrough sub-1.8 mm corneal incisions and a postop intraocular pressure in mid-teens can be obtained.

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Davies, Rhys, Mei-Ling Cheng, and Andrew J. Tatham. "A New Angle on Angle Surgery." European Ophthalmic Review 11, no. 01 (2017): 40. http://dx.doi.org/10.17925/eor.2017.11.01.40.

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Glaucoma surgery has long relied on ab externo techniques such as augmented trabeculectomy and tube-shunt procedures. While these have excellent potential to lower intraocular pressure (IOP), they are associated with risks, including hypotony, and are therefore conventionally reserved for those with advanced glaucoma or at high risk of visual loss. Traditional filtering surgery attempts to bypass the eye’s physiological outflow pathway, however new minimally invasive glaucoma surgery (MIGS) procedures have recently been introduced that focus on the angle structures as a target for improving aq

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Lindfield, Dan, Miles R. Stanford, and Saurabh Goyal. "Glaucoma Surgery in Scleromalacia: Using Endoscopic Cyclophotocoagulation where Conventional Filtration Surgery or Angle Procedures are contraindicated." Journal of Current Glaucoma Practice 11, no. 2 (2017): 73–75. http://dx.doi.org/10.5005/jp-journals-10028-1227.

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ABSTRACT Aim To describe the surgical management of glaucoma in a patient with severe scleromalacia, and secondary angle closure. Introduction The management of glaucoma with coexisting scleromalacia plus secondary angle closure is challenging as most commonly performed incisional glaucoma surgery as well as minimally invasive glaucoma surgery (MIGS), which targets the drainage angle are all contraindicated. Case report Medically refractory glaucoma in a 60-year-old male with a 30-year history of granulomatosis with polyangiitis resulting in extensive severe scleromalacia, cicatricial lower li

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Nguyen, Anne, Brian Simon, Rebecca Doan, et al. "Advances in Excimer Laser Trabeculostomy within the Landscape of Minimally-Invasive Glaucoma Surgery." Journal of Clinical Medicine 11, no. 12 (2022): 3492. http://dx.doi.org/10.3390/jcm11123492.

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Primary open-angle glaucoma (POAG) is currently treated with a variety of surgical and non-surgical approaches. Minimally invasive glaucoma surgery (MIGS) involves several devices and procedures that lower intraocular pressure (IOP) by increasing aqueous outflow. The first laser-based MIGS procedure, Excimer Laser Trabeculostomy (ELT), has emerged as a safe and effective treatment option. This article reviews ELT within the context of alternative MIGS procedures and focuses on the historical development of ELT, principles and techniques of the ELT procedure, safety and efficacy data, compariso

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Iwasaki, Kentaro, Shogo Arimura, Yoshihiro Takamura, and Masaru Inatani. "Clinical Practice Preferences for Glaucoma Surgery in Japan in 2024." Journal of Clinical Medicine 14, no. 6 (2025): 2039. https://doi.org/10.3390/jcm14062039.

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Objectives: This study evaluated the clinical preferences of glaucoma specialists regarding glaucoma surgery and postoperative management in Japan in 2024. Methods: A survey about clinical practice preferences regarding glaucoma surgery and postoperative care was administered among 50 glaucoma specialists who were councilors in the Japan Glaucoma Society. Results: Minimally invasive glaucoma surgery (MIGS) plus phacoemulsification was the most preferred procedure for nonoperated mild to moderate cases of primary open-angle glaucoma (POAG) (94.6%) and normal tension glaucoma (NTG) (67.3%) assoc

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Emir Hassan, Fauzan, Ririn Azhari, Qoshrina Adenita, Afdila Syarfina, and Astrid Ananda. "MINIMALLY INVASIVE GLAUCOMA SURGICAL TECHNIQUES FOR OPEN-ANGLE GLAUCOMA : A SYSTEMATIC REVIEW." Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425) 9, no. 12 (2023): 77–84. http://dx.doi.org/10.61841/w7v03m86.

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Background: Glaucoma affects more than 75 million people worldwide. Intraocular pressure (IOP) lowering surgery is an important treatment for this disease. Interest in reducing surgical morbidity has led to the introduction of minimally invasive glaucoma surgeries (MIGS). Understanding the comparative effectiveness and safety of MIGS is necessary for clinicians and patients. Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts wer

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Yuasa, Yuki, Kazuyuki Hirooka, Naoki Okada, et al. "Vision-Related Quality of Life following Combined Cataract and Minimally Invasive Glaucoma Surgery or Cataract Surgery Alone in Glaucoma Patients." Journal of Clinical Medicine 12, no. 9 (2023): 3279. http://dx.doi.org/10.3390/jcm12093279.

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This study examined glaucoma patients after undergoing combined cataract and minimally invasive glaucoma surgery (MIGS), microhook ab interno trabeculotomy and goniotomy with the Kahook Dual Blade (KDB), or cataract surgery alone, and it then evaluates their vision-related quality of life (VR-QOL) following the procedure. A total of 75 eyes of 75 consecutive glaucoma patients in this prospective cohort study underwent phacoemulsification (Phaco) or phaco and MIGS (Phaco-TLO) between October 2019 and March 2022. In all cases, the National Eye Institute Visual Function Questionnaire (VFQ-25) was

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Gambini, Gloria, Matteo Mario Carlà, Federico Giannuzzi, et al. "PreserFlo® MicroShunt: An Overview of This Minimally Invasive Device for Open-Angle Glaucoma." Vision 6, no. 1 (2022): 12. http://dx.doi.org/10.3390/vision6010012.

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For moderate-to-severe glaucoma, trabeculectomy remains the “gold standard” intraocular pressure (IOP)-lowering treatment; nonetheless, this method requires extensive post-operative maintenance. Microinvasive glaucoma surgery (MIGS) treatments are designed to lessen intra- and post-operative care burden while offering an acceptable IOP decrease for individuals with mild to moderate glaucoma. The PreserFlo® MicroShunt (previously InnFocus MicroShunt) is an 8.5 mm glaucoma drainage device manufactured from poly(styrene-block-isobutylene-block-styrene) (SIBS), an extremely biocompatible and bioin

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Chihara, Etsuo, and Teruhiko Hamanaka. "Historical and Contemporary Debates in Schlemm’s Canal-Based MIGS." Journal of Clinical Medicine 13, no. 16 (2024): 4882. http://dx.doi.org/10.3390/jcm13164882.

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Glaucoma is one of the primary causes of blindness worldwide. Canal opening surgery, a type of minimally invasive glaucoma surgery (MIGS) applied in cases of mild to moderate glaucoma, has gained increasing popularity in recent years due to its efficacy in reducing the intraocular pressure, its safety profile, the simplicity of its technique, and the reduced likelihood of compromised vision. Nevertheless, the existing body of histopathological studies remains insufficient for a comprehensive understanding of post-surgical wound healing. Consequently, debates persist among researchers regarding

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Ansari, Ejaz. "Erratum to: An Update on Implants for Minimally Invasive Glaucoma Surgery (MIGS)." Ophthalmology and Therapy 6, no. 2 (2017): 243–44. http://dx.doi.org/10.1007/s40123-017-0106-6.

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Fayzrakhmanov, R. R., M. E. Kalinin, M. M. Shishkin, and O. A. Pavlovskiy. "Modern view of using gonioassociated trabeculotomy." Fyodorov journal of ophthalmic surgery, no. 3 (October 8, 2021): 77–82. http://dx.doi.org/10.25276/0235-4160-2021-3-77-82.

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Purpose. Provide data on the use of gonioscopy-assisted transluminal trabeculotomy (GATT), reflecting its effectiveness and safety when using this technique in various patient models. Material and methods. To perform the review, literature sources which were searched through the PubMed and Scopus databases up to and including 2021, using the keywords "gonioassociated trabeculotomy", "minimally invasive glaucoma surgery", "primary open-angle glaucoma", "glaucoma", "secondary glaucoma". A total of 19 articles related to the topic of the review were selected. The beginning of publications on this

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Siewert, Stefan, Swen Großmann, Christoph Brandt-Wunderlich, et al. "Development of a limbal fixation mechanism for a minimally invasive implantable glaucoma microstent." Current Directions in Biomedical Engineering 6, no. 3 (2020): 221–24. http://dx.doi.org/10.1515/cdbme-2020-3056.

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AbstractGlaucoma represents a chronic eye disease that becomes increasingly prevalent worldwide. Therapies are commonly based on the reduction of intraocular pressure (IOP). Implant devices for micro-invasive glaucoma surgery (MIGS) represent a promising therapy option in refractory cases but suffer from limitations in long term efficacy or from dislocation associated complications. Our approach of an innovative drug-eluting glaucoma microstent for MIGS was presented previously. Within the current work we developed concepts and prototypes of a mechanism for the fixation of our glaucoma microst

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Byun, Ji Yeon, Yong Koo Kang, Yong Hyun Jang, Young Kook Kim, and Dai Woo Kim. "Management of Steroid-Induced Glaucoma in a Patient with Pyoderma Gangrenosum." Journal of Clinical Medicine 12, no. 8 (2023): 2930. http://dx.doi.org/10.3390/jcm12082930.

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Pyoderma gangrenosum (PG) is an uncommon inflammatory skin disorder typically presenting as painful skin ulcers, which may also exhibit extracutaneous findings. PG can occur at the site of trauma or surgery, which is known as the pathergic phenomenon. A 36-year-old man developed bilateral steroid-induced glaucoma after prolonged systemic immunosuppressive treatment for cutaneous pyoderma gangrenosum. After successful Ahmed glaucoma valve implantation surgery with donor scleral patch graft in the right eye, the same surgery failed repeatedly in the left eye and complicated with the prolonged co

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Kasahara, Masayuki, and Nobuyuki Shoji. "Visual Function After Schlemm’s Canal-Based MIGS." Journal of Clinical Medicine 14, no. 7 (2025): 2531. https://doi.org/10.3390/jcm14072531.

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Filtration surgery is highly effective in lowering intraocular pressure; however, it is associated with a higher risk of severe complications. Visual dysfunction may persist in relatively uneventful cases because of induced astigmatism or worsening optical aberrations. Therefore, for early- to moderate-stage glaucoma, an increasing number of surgeons are prioritizing surgical safety and preserving postoperative visual function by opting for minimally invasive glaucoma surgery (MIGS). Among the various MIGS techniques, canal-opening surgery—targeting aqueous outflow through the Schlemm’s canal

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Widder, Jared R., and Joseph W. Schmitz. "Combining Ab Interno Kahook Trabeculectomy with Gonioscopy-Assisted Transluminal Trabeculotomy Reduces Intraocular Pressure." Military Medicine 184, no. 11-12 (2019): 934–36. http://dx.doi.org/10.1093/milmed/usz067.

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Abstract Minimally invasive glaucoma surgery (MIGS) provides a safe option for individuals with mild to moderate open-angle glaucoma to reduce their need for pharmacologic therapy or more extensive ab externo surgeries. In this report, we describe a surgical technique using both the Kahook Dual Blade and Gonioscopy-assisted transluminal trabeculotomy (GATT), to treat a 23-year-old active duty female with idiopathic uveitis and subsequent corticosteroid-induced glaucoma who presented with consistently elevated intraocular pressure (IOP) measurements despite maximal pharmacologic interventions.

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Shih, Tung-Lun. "Prof. Keith Barton: innovations brought by minimally invasive glaucoma surgery (MIGs) are beneficial to glaucoma patients." Annals of Eye Science 3 (2018): 34. http://dx.doi.org/10.21037/aes.2018.06.05.

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Chihara, Etsuo, Eri Nakano, and Tomoyuki Chihara. "Diabetes Mellitus: A Risk Factor in Schlemm’s Canal-Based Minimally Invasive Glaucoma Surgery." Journal of Clinical Medicine 13, no. 24 (2024): 7660. https://doi.org/10.3390/jcm13247660.

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Objectives: The objective of this study was to evaluate the impact of diabetes mellitus (DM) on the outcome of Schlemm’s canal-based minimally invasive glaucoma surgery (MIGS). Methods: In a retrospective interventional cohort study, postoperative intraocular pressure (IOP) and intracameral bleeding were analyzed in 25 diabetic patients and 84 non-diabetic patients, with primary open-angle glaucoma (POAG) or ocular hypertension (OH). Results: The mean follow-up period for all 109 eyes was 35.3 ± 24.8 months. There was no significant difference in preoperative IOP between cohorts with or withou

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Yamanaka, Toshiro, Tomonori Niino, Seiji Omata, et al. "Bionic eye system mimicking microfluidic structure and intraocular pressure for glaucoma surgery training." PLOS ONE 17, no. 7 (2022): e0271171. http://dx.doi.org/10.1371/journal.pone.0271171.

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Among increasing eye diseases, glaucoma may hurt the optic nerves and lead to vision loss, the treatment of which is to reduce intraocular pressure (IOP). In this research, we introduce a new concept of the surgery simulator for Minimally Invasive Glaucoma Surgery (MIGS). The concept is comprised of an anterior eye model and a fluidic circulatory system. The model made of flexible material includes a channel like the Schlemm’s canal (SC) and a membrane like the trabecular meshwork (TM) covering the SC. The system can monitor IOP in the model by a pressure sensor. In one of the MIGS procedures,

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Resende, Arthur Fernandes, Neal Sanjay Patel, Michael Waisbourd, and L. Jay Katz. "iStent® Trabecular Microbypass Stent: An Update." Journal of Ophthalmology 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/2731856.

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Due to the high rates of complications and failure experienced with current glaucoma procedures, there is a continuous search for a safer and more effective glaucoma surgery. A new class of procedures termed minimally invasive glaucoma surgeries (MIGS) aim to fill this void by offering an alternative method of IOP reduction associated with markedly reduced complication rates and shorter recovery times. The iStent, a trabecular microbypass stent, is a MIGS device that has quickly gained popularity. The device allows aqueous humor to directly drain from the anterior chamber into Schlemm’s canal

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Bloom, Philip, and Leon Au. ""Minimally Invasive Glaucoma Surgery (MIGS) Is a Poor Substitute for Trabeculectomy"—The Great Debate." Ophthalmology and Therapy 7, no. 2 (2018): 203–10. http://dx.doi.org/10.1007/s40123-018-0135-9.

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Luo, Jinyuan, Greymi Tan, Kai Xin Thong, et al. "Non-Viral Gene Therapy in Trabecular Meshwork Cells to Prevent Fibrosis in Minimally Invasive Glaucoma Surgery." Pharmaceutics 14, no. 11 (2022): 2472. http://dx.doi.org/10.3390/pharmaceutics14112472.

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The primary cause of failure for minimally invasive glaucoma surgery (MIGS) is fibrosis in the trabecular meshwork (TM) that regulates the outflow of aqueous humour, and no anti-fibrotic drug is available for intraocular use in MIGS. The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway is a promising anti-fibrotic target. This study aims to utilise a novel lipid nanoparticle (LNP) to deliver MRTF-B siRNA into human TM cells and to compare its effects with those observed in human conjunctival fibroblasts (FF). Two LNP formulations were prepared with and without th

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Qidwai, Umair, Lee Jones, and Gokulan Ratnarajan. "A comparison of iStent combined with phacoemulsification and endocyclophotocoagulation (ICE2) with the PreserFlo MicroShunt and XEN-45 implants." Therapeutic Advances in Ophthalmology 14 (January 2022): 251584142211256. http://dx.doi.org/10.1177/25158414221125697.

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Background: Minimally invasive glaucoma surgery (MIGS), including minimally invasive bleb surgery (MIBS), is a rapidly evolving area of research and clinical interest in ophthalmology. The growing number of devices has necessitated evaluations to identify subtle differences in outcomes between treatments. Objectives: To compare clinical effectiveness and safety outcomes of iStent combined with endoscopic cyclophotocoagulation (ICE2) with bleb forming PreserFlo MicroShunt (PMS) and XEN-45 gel implant in a 24-month retrospective review. Design: A retrospective review of patient records. Methods:

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Gao, Xinbo, Aiguo Lv, Fengbin Lin, et al. "Efficacy and safety of trabeculectomy versus peripheral iridectomy plus goniotomy in advanced primary angle-closure glaucoma: study protocol for a multicentre, non-inferiority, randomised controlled trial (the TVG study)." BMJ Open 12, no. 7 (2022): e062441. http://dx.doi.org/10.1136/bmjopen-2022-062441.

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IntroductionPrimary angle-closure glaucoma (PACG) is a major subtype of glaucoma that accounts for most bilateral glaucoma-related blindness globally. Filtering surgery is a conventional strategy for PACG, yet it has a long learning curve and undesirable disastrous complications. Minimally invasive glaucoma surgery (MIGS) plays an increasing role in the management of glaucoma due to its safer and faster recovery profile; cataract surgery-based MIGS is the most commonly performed such procedure in PACG. However, for patients with a transparent lens or no indications for cataract extraction, inc

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Maheshwari, Devendra, Nimrita Nagdev, Shivam Gupta, Madhavi Ramanatha Pillai, and Rengappa Ramakrishnan. "Gonioscopy-assisted transluminal trabeculotomy: A boon for challenging case scenarios." Indian Journal of Ophthalmology - Case Reports 5, no. 3 (2025): 592–93. https://doi.org/10.4103/ijo.ijo_161_25.

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Background: Trabeculectomy is the most commonly performed filtration procedure. However, the complications either early or late after an invasive procedure has stimulated the glaucoma community to search for a novel surgical approach to the management of glaucoma. The choice of therapy between medical, laser, and filtering surgery is now bridged by minimally invasive glaucoma surgeries (MIGS), which have several perks of being an ab interno approach, high safety profile, absence of filtering bleb, and rapid recovery after surgery. Among the armamentarium of the MIGS family, gonioscopy-assisted

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Ruparelia, Sunil, and Nir Shoham-Hazon. "Iris-Occlusion of XEN Gel Stent following Ab Externo Transconjunctival Implantation Technique." Case Reports in Ophthalmological Medicine 2021 (October 6, 2021): 1–3. http://dx.doi.org/10.1155/2021/2936047.

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The use of minimally invasive glaucoma surgery (MIGS) devices has become increasingly common for the management of elevated intraocular pressure (IOP) in the context of glaucoma. These technologies have traditionally been associated with fewer postoperative complications than conventional surgical techniques. However, we report on a rare case of transient XEN occlusion associated with pupil dilation following XEN gel stent implantation. This case highlights that in future XEN implantations, it may be preferable to position the XEN at a lesser angle to the iris to prevent such an occlusion. The

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Baartman, Brandon, and John Berdahl. "Recent Advances in the Understanding and Treatment of Glaucoma." US Ophthalmic Review 10, no. 02 (2017): 89. http://dx.doi.org/10.17925/usor.2017.10.02.89.

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Glaucoma is one of the leading causes of irreversible blindness worldwide, and is therefore an active area of clinical research. Recent advances have enhanced our understanding of glaucoma as well as presenting promising treatment options. Until recently, its pathology has been considered to be restricted to the eye. However, recent research suggests that glaucoma involves the central nervous system, with cerebrospinal fluid pressure (CSFp) emerging as a potential modifiable risk factor. Biomechanical characteristics dictate how the eye responds to a given pressure, and this is also the focus

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Davids, Anja-Maria, Milena Pahlitzsch, Alexander Boeker, Sibylle Winterhalter, Anna-Karina Maier-Wenzel, and Matthias Klamann. "Ab interno canaloplasty (ABiC)—12-month results of a new minimally invasive glaucoma surgery (MIGS)." Graefe's Archive for Clinical and Experimental Ophthalmology 257, no. 9 (2019): 1947–53. http://dx.doi.org/10.1007/s00417-019-04366-3.

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Siewert, Stefan, Rudolf Guthoff, Frank Kamke, et al. "Development and validation of a test facility for pivotal characterization of glaucoma drainage devices." Current Directions in Biomedical Engineering 7, no. 2 (2021): 743–46. http://dx.doi.org/10.1515/cdbme-2021-2190.

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Abstract Implant devices for micro invasive glaucoma surgery (MIGS) are gaining increasing acceptance in clinical ophthalmic use. The implant requirements are defined in international standards, such as ANSI Z80.27-2014 and the 2015 Guidance for Industry and Food and Drug Administration Staff “Premarket Studies of Implantable Minimally Invasive Glaucoma Surgical (MIGS) Devices”. The exact fluid-mechanical characterization represents a crucial part of the development and approval of innovative implant devices for MIGS. The current work describes the development and preliminary validation of a v

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Kim, Yuri, Myungjin Kim, Dai Woo Kim, and Seungsoo Rho. "XEN Gel Stent for Conjunctiva with Minimal Mobility Caused by Scleral Encircling: A Case Report." Journal of Clinical Medicine 12, no. 13 (2023): 4293. http://dx.doi.org/10.3390/jcm12134293.

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This case report describes the successful use of a XEN gel stent for controlling intraocular pressure (IOP) in a patient who had previously undergone scleral encircling for rhegmatogenous retinal detachment. The patient had very limited mobile conjunctiva due to scarring caused by the earlier surgery, which limited their options for glaucoma surgery. The XEN gel stent, a minimally invasive glaucoma surgery (MIGS) procedure that does not require opening the conjunctiva, was implanted in the subconjunctival space using an ab interno approach. Postoperative blebs were imaged using anterior segmen

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Brito, Ana Julia dos Santos, and Everson Vagner de Lucena Santos. "Tratamento do glaucoma: uma revisão integrativa da abordagem cirúrgica." Revista Eletrônica Acervo Científico 25 (June 5, 2025): e20775. https://doi.org/10.25248/reac.e20775.2025.

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Objetivo: Analisar a produção científica recente sobre as abordagens cirúrgicas utilizadas no tratamento do glaucoma, identificando suas indicações, técnicas, benefícios e limitações. Métodos: Trata-se de uma revisão integrativa da literatura. A busca foi realizada nas bases PubMed, SciELO, LILACS e Scopus, utilizando os descritores “glaucoma”, “surgical treatment”, “glaucoma surgery” e “minimally invasive glaucoma surgery”, combinados com o operador booleano AND. Foram incluídos artigos publicados entre 2021 e 2025, nos idiomas português, inglês ou espanhol. Após aplicação dos critérios de in

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Zeppieri, Marco, Ludovica Cannizzaro, Giuseppe Gagliano, et al. "Should We Fear Wipe-Out in Glaucoma Surgery?" Diagnostics 15, no. 13 (2025): 1571. https://doi.org/10.3390/diagnostics15131571.

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Wipe-out is defined as a sudden, unexplained, and irreversible loss of residual central vision following glaucoma surgery, typically in eyes with advanced visual field damage and severely compromised optic nerves. The purpose of this review is to critically assess the current incidence, risk factors, pathophysiological mechanisms, and clinical relevance of “wipe-out”, a rare but devastating complication of glaucoma surgery characterized by sudden, unexplained central vision loss postoperatively. A comprehensive literature review was conducted, analyzing key peer-reviewed studies from electroni

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Bharathi, Mahesh. "Tips and Tricks for Performing a Successful Gonioscopy-assisted Transluminal Trabeculotomy for Beginner Ophthalmic Surgeons." TNOA Journal of Ophthalmic Science and Research 63, no. 2 (2025): 135–37. https://doi.org/10.4103/tjosr.tjosr_52_25.

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Gonioscopy-assisted transluminal trabeculotomy (GATT) is a minimally invasive glaucoma surgery (MIGS) technique that enhances aqueous outflow by disrupting the trabecular meshwork and inner wall of Schlemm’s canal. Initially described for congenital glaucoma, it has gained popularity as an effective option for primary and secondary open-angle glaucoma. This article provides a comprehensive guide for beginner ophthalmic surgeons to optimize surgical efficiency, minimise complications, and improve outcomes in GATT. Key considerations include patient selection, pre-operative assessment, and intra

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Pajic, Bojan, Mirko Resan, Brigitte Pajic-Eggspuehler, Horace Massa, and Zeljka Cvejic. "Triggerfish Recording of IOP Patterns in Combined HFDS Minimally Invasive Glaucoma and Cataract Surgery: A Prospective Study." Journal of Clinical Medicine 10, no. 16 (2021): 3472. http://dx.doi.org/10.3390/jcm10163472.

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Background: The aim of the study is to investigate whether the circadian IOP rhythm can be influenced by combined cataract surgery with high frequency deep sclerotomy (HFDS) and whether intraocular pressure (IOP) can be significantly reduced by HFDS. Methods: In our study 10 patients were included, in whom 24 h IOP monitoring was installed before and after HFDS/cataract surgery using a Triggerfish. HFDS is a minimally invasive glaucoma surgery (MIGS). Results: After performed HFDS combined with cataract surgery, the IOP was reduced from 27.7 ± 2.11 mmHg to 14.4 ± 2.59 mmHg, which is highly sig

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Kennedy, Alasdair, Fadi Haddad, and Minas Georgopoulos. "Aqueous misdirection syndrome following ab interno gelatin stent can be managed successfully with anterior vitrectomy approach." European Journal of Ophthalmology 31, no. 1_suppl (2021): 16–19. http://dx.doi.org/10.1177/1120672120979196.

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Introduction: Minimally invasive glaucoma surgery (MIGS) is a relatively new surgical technique available to glaucoma surgeons. The ab interno gelatin XEN stent (XEN®45, Allergan Inc., CA, USA) drains aqueous into the subconjunctival space and is theoretically less invasive than trabeculectomy and therefore carries less risk. Aqueous misdirection syndrome (AMS) is a rare but well-recognised complication of any intraocular surgery. Only four cases have been reported following XEN stents but their management and outcome was not discussed. We present a case of AMS following XEN implantation inclu

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