Journal articles: 'MIP [Moleculary imprinted polymer]'

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Dong, Hong Xing, Qiu Li Jiang, Fei Tong, Zhen Xing Wang, and Jin Yong Tang. "Preparation of Imprinted Polymer with D-Phenylalanin on Silica Surface." Key Engineering Materials 419-420 (October 2009): 541–44. http://dx.doi.org/10.4028/www.scientific.net/kem.419-420.541.

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Silica gel was modified with polymerizable double bonds on the surface. Then the molecular imprinting polymer imprinted with D-Phenylalanin was grafted on the surface of modified silica gel. The molecularly imprinted polymer (MIP) based on the surface of silica gel was characterized by IR and scanning electron microscopy (SEM). The adsorption property of D-Phenylalanin by MIP was mearsured. The MIP with the combined functional monomers exhibited better adsorption properties and selectivity compared with the corresponding non-imprinted polymers or MIP with the single functional monomer. The material could be used in separation research field, such as packing material of high performance liquid chromatography, solid-phase extraction and so on.

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Wolska, Joanna, and Nasim Jalilnejad Falizi. "Membrane Emulsification Process as a Method for Obtaining Molecularly Imprinted Polymers." Polymers 13, no. 16 (August 23, 2021): 2830. http://dx.doi.org/10.3390/polym13162830.

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The membrane emulsification process (ME) using a metallic membrane was the first stage for preparing a spherical and monodisperse thermoresponsive molecularly imprinted polymer (TSMIP). In the second step of the preparation, after the ME process, the emulsion of monomers was then polymerized. Additionally, the synthesized TSMIP was fabricated using as a functional monomer N-isopropylacrylamide, which is thermosensitive. This special type of polymer was obtained for the recognition and determination of trace bisphenol A (BPA) in aqueous media. Two types of molecularly imprinted polymers (MIPs) were synthesized using amounts of BPA of 5 wt.% (MIP-2) and 7 wt.% (MIP-1) in the reaction mixtures. Additionally, a non-imprinted polymer (NIP) was also synthesized. Polymer MIP-2 showed thermocontrolled recognition for imprinted molecules and a higher binding capacity than its corresponding non-imprinted polymer and higher than other molecularly imprinted polymer (MIP-1). The best condition for the sorption process was at a temperature of 35 °C, that is, at a temperature close to the phase transition value for poly(N-isopropylacrylamide). Under these conditions, the highest levels of BPA removal from water were achieved and the highest adsorption capacity of MIP-2 was about 0.5 mmol g−1 (about 114.1 mg g−1) and was approximately 20% higher than for MIP-1 and NIP. It was also observed that during the kinetic studies, under these temperature conditions, MIP-2 sorbed BPA faster and with greater efficiency than its non-imprinted analogue.

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Roland, Rachel Marcella, and Showkat Ahmad Bhawani. "Synthesis and Characterization of Molecular Imprinting Polymer Microspheres of Piperine: Extraction of Piperine from Spiked Urine." Journal of Analytical Methods in Chemistry 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/5671507.

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Molecularly imprinted polymer (MIP) microspheres for Piperine were synthesized by precipitation polymerization with a noncovalent approach. In this research Piperine was used as a template, acrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and 2,2′-azobisisobutyronitrile (AIBN) as an initiator and acetonitrile as a solvent. The imprinted and nonimprinted polymer particles were characterized by using Fourier transform infrared spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM). The synthesized polymer particles were further evaluated for their rebinding efficiency by batch binding assay. The highly selected imprinted polymer for Piperine was MIP 3 with a composition (molar ratio) of 0.5 : 3 : 8, template : monomer : cross-linker, respectively. The MIP 3 exhibits highest binding capacity (84.94%) as compared to other imprinted and nonimprinted polymers. The extraction efficiency of highly selected imprinted polymer of Piperine from spiked urine was above 80%.

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Hasanah, Aliya Nur, Nisa Safitri, Aulia Zulfa, Neli Neli, and Driyanti Rahayu. "Factors Affecting Preparation of Molecularly Imprinted Polymer and Methods on Finding Template-Monomer Interaction as the Key of Selective Properties of the Materials." Molecules 26, no. 18 (September 16, 2021): 5612. http://dx.doi.org/10.3390/molecules26185612.

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Molecular imprinting is a technique for creating artificial recognition sites on polymer matrices that complement the template in terms of size, shape, and spatial arrangement of functional groups. The main advantage of Molecularly Imprinted Polymers (MIP) as the polymer for use with a molecular imprinting technique is that they have high selectivity and affinity for the target molecules used in the molding process. The components of a Molecularly Imprinted Polymer are template, functional monomer, cross-linker, solvent, and initiator. Many things determine the success of a Molecularly Imprinted Polymer, but the Molecularly Imprinted Polymer component and the interaction between template-monomers are the most critical factors. This review will discuss how to find the interaction between template and monomer in Molecularly Imprinted Polymer before polymerization and after polymerization and choose the suitable component for MIP development. Computer simulation, UV-Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Proton-Nuclear Magnetic Resonance (1H-NMR) are generally used to determine the type and strength of intermolecular interaction on pre-polymerization stage. In turn, Suspended State Saturation Transfer Difference High Resolution/Magic Angle Spinning (STD HR/MAS) NMR, Raman Spectroscopy, and Surface-Enhanced Raman Scattering (SERS) and Fluorescence Spectroscopy are used to detect chemical interaction after polymerization. Hydrogen bonding is the type of interaction that is becoming a focus to find on all methods as this interaction strongly contributes to the affinity of molecularly imprinted polymers (MIPs).

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Huang, Chuixiu, and Xiantao Shen. "Janus molecularly imprinted polymer particles." Chem. Commun. 50, no. 20 (2014): 2646–49. http://dx.doi.org/10.1039/c3cc49586h.

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Janus MIP particles were synthesized via a wax–water Pickering emulsion. The MIP microtransporter concept provided the Janus MIP particles with attractive capabilities for autonomous binding and controlled drug delivery.

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Tadi, Kiran Kumar, and Ramani V. Motghare. "Synthesis and Evaluation of Molecularly Imprinted Polymer for Oxalic Acid." Advanced Materials Research 622-623 (December 2012): 229–35. http://dx.doi.org/10.4028/www.scientific.net/amr.622-623.229.

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Molecular imprinting technology is a convenient approach for preparing synthetic receptors that possesses user defined recognition properties. Oxalic acid imprinted bulk polymer was synthesized by thermal initiated free radical co-polymerization of oxalic acid (template) with two different functional monomers (acrylamide and methacrylic acid) and ethylene glycol dimethacrylate as crosslinker, using acetonitrile (porogen) as solvent. Scanning electron microscopy and FT-IR spectra confirmed the formation of molecularly imprinted polymer (MIP) with acrylamide. The synthesized MIP(ACR)efficiently adsorbed oxalic acid from aqueous solutions. The binding parameters of molecularly imprinted polymer and non-imprinted polymer were compared by Langmuir-Freundlich adsorption (LF) isotherm.

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Derz, Wiebke, Melita Fleischmann, and Paul W. Elsinghorst. "Guiding Molecularly Imprinted Polymer Design by Pharmacophore Modeling." Molecules 26, no. 16 (August 23, 2021): 5101. http://dx.doi.org/10.3390/molecules26165101.

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Molecularly imprinted polymers (MIP) combine the selectivity of immunoaffinity chromatography with the robustness of common solid-phase extraction in what is referred to as molecularly imprinted solid-phase extraction (MISPE). This contribution shows how MIP design may be guided by pharmacophore modeling for the example of citrinin, which is an emerging mycotoxin from cereals. The obtained pharmacophore model allowed searching public databases for a set of citrinin-mimicking molecular surrogates. Imprinted and non-imprinted polymers were subsequently obtained through bulk and core-shell polymerization in the presence of these surrogates. Evaluation of their binding ability for citrinin and structurally related ochratoxin A revealed a promising MIP derived from rhodizonic acid. A protocol for MISPE of citrinin from cereals was subsequently developed and compared to immunoaffinity chromatography with respect to clean-up efficiency and recovery.

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Baek, In-Hyuk, Hyung-Seop Han, Seungyun Baik, Volkhard Helms, and Youngjun Kim. "Detection of Acidic Pharmaceutical Compounds Using Virus-Based Molecularly Imprinted Polymers." Polymers 10, no. 9 (September 1, 2018): 974. http://dx.doi.org/10.3390/polym10090974.

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Molecularly imprinted polymers (MIPs) have proven to be particularly effective chemical probes for the molecular recognition of proteins, DNA, and viruses. Here, we started from a filamentous bacteriophage to synthesize a multi-functionalized MIP for detecting the acidic pharmaceutic clofibric acid (CA) as a chemical pollutant. Adsorption and quartz crystal microbalance with dissipation monitoring experiments showed that the phage-functionalized MIP had a good binding affinity for CA, compared with the non-imprinted polymer and MIP. In addition, the reusability of the phage-functionalized MIP was demonstrated for at least five repeated cycles, without significant loss in the binding activity. The results indicate that the exposed amino acids of the phage, together with the polymer matrix, create functional binding cavities that provide higher affinity to acidic pharmaceutical compounds.

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Aprilia, Suci. "PENGARUH MILLING TERHADAP KARAKTERISTIK MOLECULARLY IMPRINTED POLYMER KARBARIL (C12H11NO2)." JOURNAL ONLINE OF PHYSICS 5, no. 2 (July 25, 2020): 1–5. http://dx.doi.org/10.22437/jop.v5i2.9430.

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Molecularly Imprinted Polymer (MIP) has been synthesized with carbaryl used as a template and forms complex bonds with Methacrylic Acid (MAA)through hydrogen bonds, followed by a cross-linking process using Ethylene Glycol Dimethacrylate (EGDMA) cross-linkers. The polymerization process begins with the thermal decomposition of Benzoyl Peroxide (BPO) as an initiator. Non-Imprinted Polymer (NIP) as a control polymer has also been synthesized using a similar procedure without using carbaryl templates. In this study, two variations of carbaryl are used, which are not milled carbamates, and carbaryl has been milled using High Energy Milling (HEM). The FTIR study was carried out to investigate the presence of carbaryl in polymers, MIP, and NIP. The spectrum shows that the concentration of carbaryl compound decreases after the extraction process. This result was also confirmed by the increase in the value of the percentage of transmittance in the MIP, especially the nano carbaryl MIP. This result is supported by the X-RD results, which showed a decrease in the size of the crystals in the carbaryl MIP from 10.07 Å while the nano carbaryl MIP was 9.16 Å.

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Guo, Yan, Leilei Kang, Shaona Chen, and Xin Li. "High performance surface-enhanced Raman scattering from molecular imprinting polymer capsulated silver spheres." Physical Chemistry Chemical Physics 17, no. 33 (2015): 21343–47. http://dx.doi.org/10.1039/c5cp00206k.

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Driven by the ultrasensitivity of the surface-enhanced Raman scattering (SERS) technique and the directive selection of molecular imprinting polymers (MIPs), core–shell silver-molecularly imprinted polymer (Ag@MIP) hybrid structure was synthesized to serve as a novel SERS platform.

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Yoshimi, Yasuo, Daichi Oino, Hirofumi Ohira, Hitoshi Muguruma, Ewa Moczko, and Sergey Piletsky. "Size of Heparin-Imprinted Nanoparticles Reflects the Matched Interactions with the Target Molecule." Sensors 19, no. 10 (May 27, 2019): 2415. http://dx.doi.org/10.3390/s19102415.

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It has been shown that the faradic current at an electrode grafted with molecularly imprinted polymer (MIP) is sensitive to the specific target molecule used as the template. This phenomenon is applicable to sensors with very high selectivity, but the sensing mechanism is still a black box. We investigated the size sensitivity of nanoparticles of molecularly imprinted polymers (MIP-NPs) to a specific interaction for determination of the mechanism of the gate effect and its feasibility for new applications. Nanoparticles of poly(methacryloxy ethyl trimethylammonium chloride-co-acrylamide-co-methylenebisacrylamide) imprinted with heparin immobilized on glass beads were synthesized. The diameter of the MIP-NPs of heparin was increased by the presence of the heparin template but was insensitive to chondroitin sulfate C (CSC), the analogue of heparin. The high selectivity of the MIP-NPs was consistent with the selectivity of electrodes grafted with a heparin-imprinted polymer in our previous studies. The quartz crystal microbalance probes immobilizing heparin or CSC were sensitive to MIP-NPs, which indicates that the binding ability of MIP-NP does not discriminate between the template and other glycosaminoglycans. These results indicate that the size of the MIP-NP is sensitive to the matched binding with the template through the imprinted cavity.

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Turner, Nicholas W., Clovia I. Holdsworth, Adam McCluskey, and Michael C. Bowyer. "N-2-Propenyl-(5-dimethylamino)-1-naphthalene Sulfonamide, a Novel Fluorescent Monomer for the Molecularly Imprinted Polymer-Based Detection of 2,4-Dinitrotoluene in the Gas Phase." Australian Journal of Chemistry 65, no. 10 (2012): 1405. http://dx.doi.org/10.1071/ch12155.

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Fluorescent molecularly imprinted polymers (MIP) specific for 2,4-dinitrotoluene (DNT) have been synthesised using a novel monomer N-2-propenyl-(5-dimethylamino)-1-naphthalene sulfonamide. Three formats of the polymer were produced: a traditional bulk monolith ground into particles, a flexible, but highly cross-linked plasticiser-modified free standing membrane, and a hybrid material consisting of particles embedded in a poly(acrylonitrile) phase inversed film. Within all materials, a clearly defined imprinting effect was observed upon exposure to DNT vapour at room temperature. In all cases, preferential rebinding of DNT to the molecularly imprinted materials (3–5 times) over their non-imprinted (NIP) equivalents was evident within <10 min of contact with the DNT vapour stream. Fluorographic images of the fluorescent polymers showed the DNT binding-induced quenching to be significantly higher in the MIP material than in the non-imprinted control polymer.

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Zhang, Hai Hui, Fei Fei Xu, Yu Qing Duan, Can Zhang, Yong Sheng Yan, Gui Bo Sun, and Xiao Bo Sun. "Selective Adsorption and Pre-Concentration of Morin by Molecularly Imprinted Polymers with Chitosan Beads as Functional Matrix." Advanced Materials Research 781-784 (September 2013): 756–59. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.756.

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To separate and enrich morin, a molecularly imprinted polymer (MIP) was synthesized on chitosan by surface molecular imprinting technique and characterized with Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The results showed that MIP possessed better selectivity and recognition for morin in a mixture than that of non-imprinted polymer (NIP). The saturated adsorption amount of MIP was 8.0 mg/g, which was 4-fold than that of NIP, and the recovery in the elution step was 94.87% and 10.97% for MIP and NIP, respectively. These findings indicate MIP could realize the separation and pre-concentration of morin in real sample and may be used for solid phase extraction (MIP-SPE) protocol.

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Linn, Cao Nhat, Olga V. Duvanova, Svetlana Yu Nikitina, and Alexander N. Zyablov. "THE USE OF PIEZOSENSORS FOR DETERMINATION OF CARBOXYLIC ACIDS IN THE INTERMEDIATE PRODUCTS OF EDIBLE ETHANOL PRODUCTION." Industrial laboratory. Diagnostics of materials 85, no. 4 (May 15, 2019): 11–16. http://dx.doi.org/10.26896/1028-6861-2019-85-4-11-16.

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The reference polymers and polymers with molecular imprints of carboxylic acids (MIPs-CA) — propionic (MlP-Propionic) and butyric (MIP-Butyric) acids — were synthesized on the surface of piezoelectric sensors using aromatic compounds by the non-covalent imprinting method. Molecularly imprinted polymer (MIP) is a polymer produced through molecular imprinting, which leaves cavities in the polymer matrix with affinity to a chosen "template" target molecule. The values of the imprinting factor and selectivity coefficients were calculated to assess the ability of MIPs-CA to recognize the target molecules. It is shown that the sensors modified by the molecularly imprinted polymers exhibit high selectivity for the acid that was a template during their synthesis. The detection limits for propionic and buty ric acids are 7.40 x 10~6 and 8.81 x 10-6 g/dm3, respectively. Correctness of the carboxylic acid determination in model solutions was verified in the spike/recovery tests. The relative standard deviation is less than 10%. The modified piezoelectric sensors were tested in analysis of the intermediate products of edible ethanol production (distillate of fermentation mixture, epyurat, bottom liquids of columns). The correctness of the determination of carboxylic acids in liquids was evaluated using an Agilent Technological 7890B GC Systems. The difference in the results of acid determination between both methods (piezoelectric sensor and chromatography-mass spectrometry) does not exceed 6%. The modified piezosensors expand the potential of rapid determination of carboxylic acids in the intermediate products of ethyl alcohol production.

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Wu, Yunbo, Yi Li, Aijun Tian, Kai Mao, and Jian Liu. "Selective Removal of Perfluorooctanoic Acid Using Molecularly Imprinted Polymer-Modified TiO2Nanotube Arrays." International Journal of Photoenergy 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/7368795.

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Perfluorinated chemicals have attracted worldwide concern owing to their wide occurrence and resistance to most conventional treatment processes. In this work, a novel photocatalyst was fabricated by modifying TiO2nanotube arrays with molecularly imprinted polymers. The molecularly imprinted polymer-modified TiO2nanotubes (MIP-TiO2NTs) were characterized and tested for the selective removal of perfluorooctanoic acid (PFOA) from water. The amount of PFOA adsorbed by the MIP-TiO2NTs was as high as 0.8125 μg/cm2. PFOA decomposition and defluorination by the MIP-TiO2NTs reached 84% and 30.2% after 8 h reaction, respectively. The Freundlich model and pseudo-first-order kinetics were used to describe the observed adsorption and decomposition of PFOA, respectively. Compared with TiO2NTs and nonmolecularly imprinted polymer-modified TiO2NTs, the MIP-TiO2NTs exhibited not only a higher PFOA degradation rate but also enhanced selectivity for target chemicals. The MIP-TiO2NTs could also selectively and rapidly remove PFOA from secondary effluent, exhibiting a decomposition of 81.1%, almost as high as that observed in pure water. Investigation of the effects of scavengers on the photocatalytic reaction indicated that photogenerated holes were the main oxidant for PFOA decomposition, and the PFOA degradation mechanism and pathway were proposed.

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Azodi-Deilamia, Saman, Majid Abdoussa, and S. Rezvaneh Seyedib. "Synthesis and characterization of molecularly imprinted polymer for controlled release of tramadol." Open Chemistry 8, no. 3 (June 1, 2010): 687–95. http://dx.doi.org/10.2478/s11532-010-0035-x.

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AbstractIn this paper, we describe how to prepare a highly selective imprinted polymer by a bulk polymerization technique. We used tramadol as the template, (MAA) as functional monomers, and (EGDMA) as the cross-linker in chloroform as solvent. Results from Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Scanning Electron microscopy (SEM) show that this imprinted sorbent exhibits good recognition and high affinity for tramadol. Selectivity of molecularly imprinted polympers (MIP) was evaluated by comparing several substances with similar molecular structures to that of tramadol. Controlled release of tramadol from MIPs was investigated through in vitro dissolution tests and by measuring the absorbance at λmax of 272 nm by (HPLC-UV). The dissolution media employed were hydrochloric acid pH 3.0 and phosphate buffers, pH 5.0 and 7.4, maintained at 37 and 25 ± 0.5°C. The results show the ability of MIP polymers to control tramadol release. In all cases, the release of MIPs was deferred for a longer time as compared to NMIP. At a pH of 7.4 and 25°C slower release of tramadol imprinted polymer occurred.

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Shumyantseva, V. V., T. V. Bulko, I. Kh Baychorov, and A. I. Archakov. "Molecularly imprinted polymers in electro analysis of proteins." Biomeditsinskaya Khimiya 61, no. 3 (2015): 325–31. http://dx.doi.org/10.18097/pbmc20156103325.

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In the review the main approaches to creation of recognition materials capable of competing with biological specific receptors, (polymeric analogs of antibodies or molecularly imprinted polymers, MIP) for the electro analysis of functionally significant proteins such as a myoglobin, troponin T, albumin, human ferritin, calmodulin are considered. The main types of monomers for MIP fabrication, and methods for MIP/protein interactions, such as a surface plasmon resonance (SPR), nanogravimetry with use of the quartz crystal resonator (QCM), spectral and electrochemical methods are discussed. Experimental data on electrochemical registration of a myoglobin using MIP/electrode are presented. For a development of electrochemical sensor systems based on MIPs, o-phenylenediamine (1,2-diaminobenzene was used as a monomer. It was shown that the imprinting factor Imax(MIP)/Imax(NIP), calculated as a myoglobin signal ratio when embedding in MIP to a myoglobin signal when embedding in the polymer received without molecular template (NIP) corresponds 2-4.

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Azizi, Emi Shaqiza, Mohd Noor Ahmad, A. K. M. Shafiqul Islam, Dahyar Arbain, and Iqmal Tahir. "POROGEN EFFECT TOWARDS THE QUALITY OF CURCUMIN IMPRINTED POLYMER." Indonesian Journal of Chemistry 11, no. 3 (December 20, 2011): 207–11. http://dx.doi.org/10.22146/ijc.21381.

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Molecularly imprinted polymer (MIP) is gaining importance in separation technology. In this study, curcumin has been selected as template in MIP which can be applied as sorbent materials in solid-phase extraction (SPE). Effect of porogen on the quality of curcumin-MIP is very sensitive depends on the molecular size and polarity of the porogen. We varied three solvents as the porogen i.e. tetrahydrofuran (THF), chloroform (CHCl3) and acetonitrile (MeCN). The MIP was prepared using non-covalent approach through bulk polymerization and non-imprinted polymer (NIP) as control, also prepared using the same procedure in the absence of template. The largest imprinting factor, 1.27 was obtained from polymer P1 at ratio 1:4 of template: functional monomer. The P1 was prepared using methacrylic acid (MAA) as functional monomer and tetrahydrofuran (THF) as porogen with the highest average pore diameter i.e. 618.43 nm trough gas adsorption analysis. This will lead to better access of curcumin during batch binding analysis.

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Saifuddin, N., and A. A. Nur Yasumira. "Microwave Enhanced Synthesis of Chitosan-graftMolecularly Imprinted Polymer (MIP) for Selective Extraction of Antioxidants." E-Journal of Chemistry 7, no. 4 (2010): 1362–74. http://dx.doi.org/10.1155/2010/402698.

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Polymers have been molecularly imprinted for the purpose of binding specifically toα-tocotrienol (vitamin E). A molecularly imprinted polymer (MIP) material was prepared usingα-tocotrienol as the imprinted molecule, acrylamide as functional monomer and macroporous chitosan beads as functional matrix. Chitosan-graft-polyacrylamide was synthesized without any radical initiator or catalyst using microwave (MW) irradiation. The representative microwave synthesized graft copolymer was characterized by fourier transform-infrared spectroscopy, taking chitosan as a reference. Microwave irradiation was exploited for polyacrylamide grafting on the cross-linked chitosan beads to produce MIP, where both time as well as chemicals can be saved. It can be assumed that the chitosan coated polyacrylamide MIP will have better pH stability and enhanced adsorption capacity. The maximum adsorption capacity was observed to be 3.95 mg/g of MIP, which gave removal efficiency of 93%. After 4 h, the change of adsorption capacities forα-tocotrienol did not show notable effects. The Langmuir and Freundlich adsorption models were also applied to describe the equilibrium isotherms.

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Guzzella, L., F. Pozzoni, and C. Baggiani. "Synthesis and characterization of a propazine imprinted polymer for the extraction of triazines herbicides." Water Science and Technology 57, no. 1 (January 1, 2008): 139–44. http://dx.doi.org/10.2166/wst.2008.812.

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A MIP (molecularly imprinted polymer) was synthesized and evaluated for its use as sorbent for solid phase extraction (MISPE) of common used triazines (atrazine and terbuthylazine) and their widespread metabolites (desethyl-atrazine and desethyl-terbuthylazine) in water samples. MIP was produced by bulk polymerisation using methacrylic acid as functional monomer, ethylene glycol dimethacrylate as cross-linker, propazine as template and toluene as porogen solvent. Different washing methods of the synthesized polymer were evaluated. Soxhlet extraction provided the best results with a residual concentration of propazine, ranging from 0.78 to 2.86 μg for 1 g of polymer. Capacity factor was calculated using a 5 cm HPLC column filled with MIP and NIP (Not Imprinted Polymer): data extrapolation indicated a log Kw of 4.3 for MIP and a log Kw of 3.5 for NIP. Also frontal analyses confirmed a different behaviour of the two polymers. By comparing the recovery efficiency of MIP with that of traditional LiChrolut EN cartridge in the extraction of a River Po water sample, the results confirmed the reliability of this new technique for the analysis of herbicide compounds.

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Sakata, Toshiya, Shoichi Nishitani, and Taira Kajisa. "Molecularly imprinted polymer-based bioelectrical interfaces with intrinsic molecular charges." RSC Advances 10, no. 29 (2020): 16999–7013. http://dx.doi.org/10.1039/d0ra02793f.

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A molecularly imprinted polymer (MIP)-based membrane with phenylboronic acid (PBA) molecules, which induces the change in the density of molecular charges, is suitable for the bioelectrical interface of field-effect transistor (FET) sensors.

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Bakhtiar, Salma, Showkat Ahmad Bhawani, and Syed Rizwan Shafqat. "Synthesis and Characterization of Molecularly Imprinted Polymer for the Removal/Extraction of Thymol from Spiked Blood Serum and River water." Asian Journal of Chemistry 31, no. 11 (September 28, 2019): 2479–84. http://dx.doi.org/10.14233/ajchem.2019.22151.

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Molecularly imprinted polymers (MIPs) were prepared by precipitation polymerization using thymol as a template molecule, acrylamide as a functional monomer and N,N-methylbisacrylamide as the crosslinker with a non-covalent approach. The polymers were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), fourier-transform infra red spectroscopy(FT-IR) and Brunauer-Emmett-Teller (BET). The SEM results depicted that the shape of polymer particles is spherical with uniform size (micro-meters). The BET results also showed better surface area, pore size and pore volume of MIP as compared to non-imprinted polymer (NIP). A series of parameters such as initial concentration, polymer dosage, effect of pH and slectivity with structural analogue were conducted. The selectivity of MIP towards thymol was appreciable as compared to its structural analogue gallic acid with a relative selectivity coefficient of 3.59. Finally, MIP has been successfully used for extraction of thymol from the spiked blood serum (84 %) and river water sample (98 %).

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Branger and Brisset. "Advanced Electrochemical Molecularly Imprinted Polymer as Sensor Interfaces." Proceedings 15, no. 1 (July 12, 2019): 22. http://dx.doi.org/10.3390/proceedings2019015022.

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Electrochemical molecularly imprinted polymers (e-MIP) are MIP specially designed to detect aromatic organic molecules without redox properties. The detection is based on the electrochemical answer of a redox probe inserted inside the binding cavities of cross-linked MIPs. Microbeads of e-MIP were synthesized from vinylferrocene or ferrocenylmethyl methacrylate as functional monomer/redox probe with or without 4-vinylpyridine functional as co-monomer, benzo[a]pyrene or bisphenol A as the target and ethylene glycol dimethacrylate of divinylbenzene as cross-linker. After physico-chemical characterization, e-MIP microbeads were incorporated in a graphite paste to prepare modified electrode or screen-printed carbon electrodes (SPCE).

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BHAWANI, SHOWKAT AHMAD, NURSUHAILAH BINTI SUHAILI, RACHEL MARCELLA ROLAND, SALMA BAKHTIAR, KHALID M. ALOTAIBI, and MOHAMMAD NASIR MOHAMMAD IBRAHIM. "Template Assisted Synthesis of Molecularly Imprinted Polymer for the Extraction of p-Coumaric Acid." Asian Journal of Chemistry 32, no. 9 (2020): 2342–46. http://dx.doi.org/10.14233/ajchem.2020.22833.

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In present study, the molecular imprinting polymer (MIP) of p-coumaric acid was synthesized by using p-coumaric acid as a template, acetonitrile as solvent, 1,4-butanediol dimethacrylate as cross-linker, acrylic acid as monomer and 2,2-azobisisobutironitrile (AIBN) as the initiator. The synthesized polymers were characterized by FTIR and SEM. The results from SEM revealed that the polymer was in spherical shape with size in micro-range. The binding efficiency of polymers was analyzed by adsorption study. The highest rebinding efficiency for MIP was ~ 80% while for non-imprinted polymer (NIP) it was only 24%.

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Halim, Nurul Farhanah Ab, M. Noor Ahmad, A. K. M. Shafiqul Islam, A. Yeon Md Shakaff, Zulkhairi Zakaria, and M. Nazree Derman. "Serine Sensor Based on Graphene Sheet Congo-Red Molecular Imprinted Polymer (GSCR-MIP) Organic Thin Film Transistor (OTFT)." Advanced Materials Research 925 (April 2014): 500–504. http://dx.doi.org/10.4028/www.scientific.net/amr.925.500.

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Molecular imprinted is a technique to produce template-shape cavities in polymer matrix with memory of the template/target molecule for chemical sensor front-end. In this study, it has been shown that the incorporation of graphene sheets/Congo red (GSCR) has enhanced the performance of molecular imprinted polymer (MIP) serine sensor. The polymer is formed via photo-polymerization from methyl methacrylate acid (functional monomer), serine (template) and ethylene glycol dimethacrylate (cross-linker) together with GSCR. By introducing GSCR-MIP, GSCR-MIP OTFT chemical sensor demonstrates a good response when serine is introduced. The performance of GSCR-MIP OTFT serine sensor can be improved through the addition of GSCR, thus GSCR-MIP has high potentials for application in sensor fabrication.

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Zheng, Xiaofeng, Sohayb Khaoulani, Nadia Ktari, Momath Lo, Ahmed M. Khalil, Chouki Zerrouki, Najla Fourati, and Mohamed M. Chehimi. "Towards Clean and Safe Water: A Review on the Emerging Role of Imprinted Polymer-Based Electrochemical Sensors." Sensors 21, no. 13 (June 23, 2021): 4300. http://dx.doi.org/10.3390/s21134300.

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This review critically summarizes the knowledge of imprinted polymer-based electrochemical sensors for the detection of pesticides, metal ions and waterborne pathogenic bacteria, focusing on the last five years. MIP-based electrochemical sensors exhibit low limits of detection (LOD), high selectivity, high sensitivity and low cost. We put the emphasis on the design of imprinted polymers and their composites and coatings by radical polymerization, oxidative polymerization of conjugated monomers or sol-gel chemistry. Whilst most imprinted polymers are used in conjunction with differential pulse or square wave voltammetry for sensing organics and metal ions, electrochemical impedance spectroscopy (EIS) appears as the chief technique for detecting bacteria or their corresponding proteins. Interestingly, bacteria could also be probed via their quorum sensing signaling molecules or flagella proteins. If much has been developed in the past decade with glassy carbon or gold electrodes, it is clear that carbon paste electrodes of imprinted polymers are more and more investigated due to their versatility. Shortlisted case studies were critically reviewed and discussed; clearly, a plethora of tricky strategies of designing selective electrochemical sensors are offered to “Imprinters”. We anticipate that this review will be of interest to experts and newcomers in the field who are paying time and effort combining electrochemical sensors with MIP technology.

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Chen, Shaona, Xin Li, Yan Guo, and Jingyao Qi. "A Ag-molecularly imprinted polymer composite for efficient surface-enhanced Raman scattering activities under a low-energy laser." Analyst 140, no. 9 (2015): 3239–43. http://dx.doi.org/10.1039/c4an02301c.

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Yao, Chuan Yi, Qing Qing Li, and Ying Hua Lu. "Preparation of MIP Microspheres by Precipitation Polymerization with 1-Phenyl-1-Propanol as Template." Advanced Materials Research 415-417 (December 2011): 1225–30. http://dx.doi.org/10.4028/www.scientific.net/amr.415-417.1225.

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Molecular imprinting polymer microspheres were prepared by precipitation polymerization with methacrylic acid as functional monomer and 1-phenyl-1-propanol as template. The effects of synthesis conditions, including the kind of solvent, polymerization temperature, the concentration of template and initiator, rotational speed and pre-polymerization time, on the characteristics of the molecularly imprinted polymer microspheres were studied. The rebinding experiments showed that the molecularly imprinted polymer microspheres synthesized by precipitation polymerization at 60°C, with acetonitrile as solvent and the concentrations of both template and initiator of 0.01mol L-1, have good specific recognition and higher affinity capacity.

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Chen, Xiao-Hong, Yong-Gang Zhao, Yun Zhang, Hao-Yu Shen, Sheng-Dong Pan, and Mi-Cong Jin. "Ethylenediamine-functionalized superparamagnetic carbon nanotubes for magnetic molecularly imprinted polymer matrix solid-phase dispersion extraction of 12 fluoroquinolones in river water." Analytical Methods 7, no. 14 (2015): 5838–46. http://dx.doi.org/10.1039/c5ay00609k.

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Wei, Wenchao, Rongning Liang, Zhuo Wang, and Wei Qin. "Hydrophilic molecularly imprinted polymers for selective recognition of polycyclic aromatic hydrocarbons in aqueous media." RSC Advances 5, no. 4 (2015): 2659–62. http://dx.doi.org/10.1039/c4ra12555j.

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Nagy-Szakolczai, Anett, Zsanett Dorkó, Blanka Tóth, and George Horvai. "New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents." Polymers 10, no. 9 (September 12, 2018): 1015. http://dx.doi.org/10.3390/polym10091015.

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This work presents three new experimental methods for studying molecular imprinting. The electric conductivity measurements of the pre-polymerization mixture of amine templates in an aprotic solvent provide evidence of ionic dissociation of the pre-polymerization complexes. The displacement measurement of the template propranolol from its molecularly imprinted polymer (MIP) using a quaternary ammonium ion in toluene, shows that this MIP behaves as an ion exchanger even in a non-polar solvent. The same experiment also shows that template binding to the MIP from toluene involves ionic interaction. The third experimental method introduced here serves to study the models of template binding on MIPs. To this end the binding isotherm of propranolol (PR) has been measured on a polymer mixture consisting of non-imprinted control polymer (NIP) and a stronger binding acidic polymer, respectively. All three methods are suitable for studying several other imprinting systems.

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Roland, Rachel Marcella, and Showkat Ahmad Bhawani. "Synthesis of Molecularly Imprinted Polymer for the Removal of Melamine." Asian Journal of Chemistry 31, no. 12 (November 16, 2019): 2770–76. http://dx.doi.org/10.14233/ajchem.2019.22243.

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In this article, molecularly imprinted polymer (MIP) of melamine was synthesized by non-covalent approach using microemulsion medium. In this study, melamine is used as a template molecule, acrylic acid as a functional monomer, N,N′-methylenebis(acrylamide) (MBAm) as a cross-linker and 2,2′-azobisisobutyronitrile (AIBN) as an initiator and microemulsion as a solvent. The produced polymers were characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) and thermogravimetric analysis (TGA). The batch binding analysis was conducted for the evaluation of MIP and NIP rebinding efficiency with the melamine template. The adsorption studies including the adsorbent dosage of polymer, initial concentrations and pH of melamine solution were successfully carried out on both MIP and NIP. For selectivity test, 2,4,6-trichlorophenol was chosen as the competitive molecule against melamine template. A very good relative selectivity coefficient was achieved. The removal of melamine from different samples were conducted successfully by achieving a good removal efficiency in milk, river water and human blood serum 84.30, 94.26 and 93.32 %, respectively.

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Sun, Ling Zhi, Cheng Jun Sun, Yong Qin Fang, and Xian Xiang Sun. "Synthesis of Nimetazepam - Molecularly Imprinted Polymer and SPE Application." Advanced Materials Research 699 (May 2013): 200–206. http://dx.doi.org/10.4028/www.scientific.net/amr.699.200.

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The synthesis and performance of a molecularly imprinted polymer (MIP) designed to enable the clean-up of the interferences existing in alprazolam (Alpra) drug samples is described. The MIP was synthesized using non-covalent molecularly imprinted method. Nimetazepam (Nimet), which has a similar chemical structure as the major impurities in Alpra drug samples, was used as the dummy template. Methacrylic acid was used as the monomer. Both the affinity and selectivity of the MIP for Nimet and structurally related compounds were examined through batch-rebinding studies. The specific binding amount of Nimet was determined to be 11.4 mg•g-1. The MIP was used as the sorbent in solid phase extraction (MI-SPE) and methanol was used as the washing solvent for the clean-up of Nimet in the Alpra complex samples. The effective clean-up of Nimet was achieved, with a recovery > 90% for Alpra, in the stimulated samples.

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Chrisnandari, Rosita Dwi. "Sintesis dan Karakterisasi Molecularly Imprinted Polymer Untuk Kloramfenikol Menggunakan Polimerisasi Fasa Ruah." Journal of Pharmacy and Science 3, no. 1 (January 7, 2018): 40–46. http://dx.doi.org/10.53342/pharmasci.v3i1.74.

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Kloramfenikol adalah antibiotik yang memiliki aktivitas untuk melawan bakteri gram positif dan gram negatif yang pemakaiannya dibatasi dan diawasi oleh lembaga pemerintahan karena memiliki efek samping yang membahayakan kesehatan manusia dan lingkungan. Metode analisis kloramfenikol yang digunakan umumnya kurang selektif dan kurang spesifik terhadap kloramfenikol. Pada penelitian ini dikembangkan teknik preparasi sampel berbasis molecularly imprinted polymer (MIP) yang dapat digunakan sebagai adsorben selektif dan spesifik terhadap kloramfenikol. MIP disintesis menggunakan kloramfenikol sebagai template, asam metakrilat (MAA) sebagai monomer, etilen glikol dimetakrilat (EGDMA) sebagai cross-linker dan kloroform sebagai porogen dengan perbandingan mol rasio template:monomer:cross-linker sebesar 1:4:20 secara polimerisasi fasa ruah pada suhu 70 ºC selama 11 jam. Elusi template dilakukan melalui ekstraksi pelarut menggunakan metanol:asam asetat 9:1 (v/v). Non-imprinted polymer (NIP) dan polimer kontrol juga disintesis sebagai pembanding. Hasil polimerisasi dikarakterisasi menggunakan fourier transform infrared spectroscopy (FT-IR) dan adsorpsi-desorpsi N2. Spektra FT-IR menunjukkan gugus fungsi spesifik kloramfenikol pada MIP tidak tampak bila dibandingkan dengan spektra NIP. Luas permukaan MIP diketahui sebesar 106,609 m2/g dan 41,860 m2/g untuk polimer kontrol. Hal ini membuktikan bahwa MIP memiliki sisi pengenal yang lebih banyak dan spesifik dibandingkan dengan polimer kontrol. MIP hasil sintesis dapat digunakan untuk meningkatkan selektivitas metode analisis kloramfenikol secara kromatografi.Kata kunci: Kloramfenikol, Molecularly Imprinted Polymer (MIP), Polimerisasi Fasa Ruah

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Zhong, Wei Min, Zheng Ping Wang, Yan Zhou, and Pan Pan Guo. "Study on the Magnetic Molecularly Imprinted Materials for Removing the Perfluorooctane Sulfonate (PFOS) in Water." Advanced Materials Research 864-867 (December 2013): 706–9. http://dx.doi.org/10.4028/www.scientific.net/amr.864-867.706.

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Molecular imprinting has been considered as one of the most useful techniques for the preparation of specific receptors. In this study, a novel molecularly imprinted material (MIP) has been developed by combining PFOS as the template with soluble polybenzimidazole which wrapped over the surface of ferroferric oxide as the carrier. Kinetics experimental showed MIP had a sorption amount of 117.6mg/g for PFOS, high than 74.6mg/g of the none-imprinted polymer adsorbents（NIP）. Additionally, in the competitive environment with other pollutants, the sorption amount of PFOS for MIP is greater than NIP, due to the electrostatic interaction in recognizing the target compound.

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Booker, Katherine, Michael C. Bowyer, Chris J. Lennard, Clovia I. Holdsworth, and Adam McCluskey. "Molecularly Imprinted Polymers and Room Temperature Ionic Liquids: Impact of Template on Polymer Morphology." Australian Journal of Chemistry 60, no. 1 (2007): 51. http://dx.doi.org/10.1071/ch06284.

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Molecularly imprinted polymers (MIPs) were generated for trans-aconitic acid 1 and cocaine 2 in a variety of porogens (CH3CN, CHCl3, [bmim][BF4], and [bmim][PF6]). MIP synthesis in either [bmim][BF4] or [bmim][PF6] resulted in significant acceleration of polymerization rates and, in the case of low temperature polymerizations, reactions were complete in less than 2 h, while no product was observed in the corresponding volatile organic carbon (VOC) porogen. In all instances, MIPs generated in [bmim][BF4] or [bmim][PF6] returned imprinting selectivities (I values) on par with or better than the corresponding MIP generated in VOCs. Imprinting values ranged between I = 1 and 2.9, with rebinding limited to 1 h. MIP synthesis conducted at low temperature (5°C) afforded the highest I values. Scanning electron microscopy examination of MIP morphology highlighted an unexpected template effect with MIP structure varying between discrete nanoparticles and robust monoliths. This template–monomer interaction was also observed in the rates of polymerizations with differences noted in reaction times for 1 and 2 MIPs, thus providing indirect conformation of our previously proposed use of molecular modelling–nuclear magnetic resonance titrations (the MM-NMR method) in the design phase of MIP generation. In addition, considerable batch-to-batch rebinding selectivities were observed.

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Longo, Luigia, and Giuseppe Vasapollo. "Phthalocyanine-Based Molecularly Imprinted Polymers as Nucleoside Receptors." Metal-Based Drugs 2008 (November 21, 2008): 1–5. http://dx.doi.org/10.1155/2008/281843.

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A molecularly imprinted polymer (MIP) for tri-O-acetyladenosine (TOAA), PPM(TOAA), was prepared by the combined use of methacrylic acid (MAA) and Zn(II)tetra(4'-methacryloxyphenoxy) phthalocyanine as functional monomers. This MIP exhibited a higher binding ability for TOAA compared to the MIP prepared using only MAA, PM(TOAA), in batch rebinding tests. Scatchard analysis gave a higher association constant of PPM(TOAA) for TOAA (2.96×104 M−1) than that of PM(TOAA) (1.48×104 M−1). The MIP prepared using only the zinc-phthalocyanine, PP(TOAA), did not show any binding capacity for TOAA. This means that the phthalocyanine in the MIP contributes to higher affinities, although it barely interacts with TOAA. Since selectivity for this kind of MIPs is more important than binding affinity, the binding of TOAA and a structurally related compound, tri-O-acetyluridine (TOAU), on the polymers was investigated. Both PPM(TOAA) and PM(TOAA) exhibited binding affinities for TOAA while they did not show any binding capacity for TOAU.

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Shang, Jiaobo, Yanqun Song, Chuan Rong, Yinghui Wang, Liwei Wang, Yuanyuan Zhang, and Kefu Yu. "Preparation and selective adsorption of organic pollutants by an inorganic molecular imprinted polymer." Water Science and Technology 74, no. 5 (June 22, 2016): 1193–201. http://dx.doi.org/10.2166/wst.2016.244.

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A novel inorganic molecular imprinted polymer (MIP) was synthesized by adding Al3+ to the Fe/SiO2 gel with Acid Orange II (AO II) as the template. The MIP was characterized by scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and nitrogen adsorption-desorption measurement. Compared with the non-imprinted polymer (NIP), the MIP enhanced the adsorption capacity of the target pollutants AO II. The selective adsorption capacity study indicated that the MIP adsorbed more AO II than the interferent Bisphenol A (BPA), which also has the structure of a benzene ring, thus proving the selective adsorption capacity of the MIP for template molecules AO II. In addition, the adsorption of AO II over MIP belonged to the Langmuir type and pseudo-second adsorption kinetics, and Dubinin-Radushkevich model indicates that the adsorption process of AO II over MIP and NIP are both given priority to chemical adsorption. The MIP reusability in performance was demonstrated in at least six repeated cycles.

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Ma, Xue, Feng Gao, Runying Dai, Guangbin Liu, Ying Zhang, Limin Lu, and Yongfang Yu. "Novel electrochemical sensing platform based on a molecularly imprinted polymer-decorated 3D-multi-walled carbon nanotube intercalated graphene aerogel for selective and sensitive detection of dopamine." Analytical Methods 12, no. 14 (2020): 1845–51. http://dx.doi.org/10.1039/d0ay00033g.

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A novel molecularly imprinted electrochemical sensor for detection of dopamine (DA) has been fabricated with multi-walled carbon nanotubes spaced graphene aerogels (MWCNTs/GAs) as sensing substrate and polypyrrole (PPy) as molecularly imprinted polymer (MIP).

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Suryana, Shendi, Mutakin, Yudi Rosandi, and Aliya Nur Hasanah. "An Update on Molecularly Imprinted Polymer Design through a Computational Approach to Produce Molecular Recognition Material with Enhanced Analytical Performance." Molecules 26, no. 7 (March 26, 2021): 1891. http://dx.doi.org/10.3390/molecules26071891.

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Molecularly imprinted polymer (MIP) computational design is expected to become a routine technique prior to synthesis to produce polymers with high affinity and selectivity towards target molecules. Furthermore, using these simulations reduces the cost of optimizing polymerization composition. There are several computational methods used in MIP fabrication and each requires a comprehensive study in order to select a process with results that are most similar to properties exhibited by polymers synthesized through laboratory experiments. Until now, no review has linked computational strategies with experimental results, which are needed to determine the method that is most appropriate for use in designing MIP with high molecular recognition. This review will present an update of the computational approaches started from 2016 until now on quantum mechanics, molecular mechanics and molecular dynamics that have been widely used. It will also discuss the linear correlation between computational results and the polymer performance tests through laboratory experiments to examine to what extent these methods can be relied upon to obtain polymers with high molecular recognition. Based on the literature search, density functional theory (DFT) with various hybrid functions and basis sets is most often used as a theoretical method to provide a shorter MIP manufacturing process as well as good analytical performance as recognition material.

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Gong, Guo Li, Lin Jia, and Hui Li. "Synthesis and Characterization of Epothilone B Molecular Imprinted Polymers." Key Engineering Materials 501 (January 2012): 37–41. http://dx.doi.org/10.4028/www.scientific.net/kem.501.37.

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Molecular imprinted polymers (MIPs) for antitumor drug Epothilone B have been synthesized with bulk polumerization in order to specifically extract this agent in the present study. MIP was prepared by thermal polymerisation using Epothilone B as template, methacrylic acid as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross-linking agent. The best synthesis progenic solvent was ultimately determined when the bonding property of the polymer was studied. The selectivity of imprinted polymer on Epothilone B was also studied. The equilibrium binding experiments showed that the binding site of MIPs was heterogeneous with one binding site. Equilibrium dissociation constant was 3.37 mg/ml, the maximum apparent adsorption was 335 mg/g.

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Shen, Hai Xia, Quan De Liu, Jie Qin, and Shi Rong Tang. "Preparation and Recognition Performance of Chloramphenicol Molecularly Imprinted Polymer." Applied Mechanics and Materials 448-453 (October 2013): 192–96. http://dx.doi.org/10.4028/www.scientific.net/amm.448-453.192.

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A new molecularly imprinted polymer, which can be used for selective adsorption of chloramphenicol (CAP) from aqueous solutions, was successfully prepared by precipitation polymerization. The adsorption kinetic curve, adsorption isotherm and selective adsorption were measured by static method. The adsorption kinetics of MIPs for CAP reached the equilibrium at about 11 hours. The maximum adsorption capacity was 43.395 mmol/g, and the MIP has much higher adsorption quantity than NIP. Competitive adsorption studies showed that MIP offers the advantages of selectivity toward CAP compared with NIP in the presence other antibiotics. The results showed that the MIP possessed good specific adsorption capacity and selectivity for CAP.

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Azodi-Deilami, Saman, Majid Abdouss, and Seyed Hasani. "Preparation and utilization of a molecularly imprinted polymer for solid phase extraction of tramadol." Open Chemistry 8, no. 4 (August 1, 2010): 861–69. http://dx.doi.org/10.2478/s11532-010-0059-2.

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AbstractIn this paper, a highly selective molecularly imprinted polymer (MIP) for tramadol hydrochloride, a drug used to treat moderate to severe pain, was prepared and its use as solid-phase extraction (SPE) sorbent was demonstrated. The molecularly imprinted solid-phase extraction procedure followed by high performance liquid chromatography with ultraviolet detector (MISPE-HPLC) was developed for selective extraction and determination of tramadol in human plasma and urine. The optimal conditions for molecularly imprinted solid-phase extraction (MISPE) consisted of conditioning with 1 mL methanol and 1 mL of deionized water at neutral pH, loading of tramadol sample (50 µg L−1) at pH 7.5, washing using 1 mL acetone and elution with 3 × 1 mL of 10% (v/v) acetic acid in methanol. The MIP selectivity was evaluated by checking several substances with similar molecular structures to that of tramadol. Results from the HPLC analyses showed that the calibration curve of tramadol (using MIP from human plasma and urine) is linear in the ranges of 6–100 and 3–120 µg L−1 with good precisions (1.9% and 2.9% for 5.0 µg L−1), respectively. The recoveries for plasma and urine samples were higher than 81%.

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Sitjar, Jaya, Ying-Chen Hou, Jiunn-Der Liao, Han Lee, Hong-Zheng Xu, Wei-En Fu, and Guo Dung Chen. "Surface Imprinted Layer of Cypermethrin upon Au Nanoparticle as a Specific and Selective Coating for the Detection of Template Pesticide Molecules." Coatings 10, no. 8 (August 1, 2020): 751. http://dx.doi.org/10.3390/coatings10080751.

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The detection of specific pesticides on food products is essential as these substances pose health risks due to their toxicity. The use of surface-enhanced Raman spectroscopy (SERS) takes advantage of the straightforward technique to obtain fingerprint spectra of target analytes. In this study, SERS-active substrates are made using Au nanoparticles (NPs) coated with a layer of polymer and followed by imprinting with a pesticide–Cypermethrin, as a molecularly imprinted polymer (MIP). Cypermethrin was eventually removed and formed as template cavities, then denoted as Au NP/MIP, to capture the analogous molecules. The captured molecules situated in-between the areas of high electromagnetic field formed by plasmonic Au NPs result in an effect of SERS. The formation of Au NP/MIP was, respectively, studied through morphological analysis using transmission electron microscopy (TEM) and compositional analysis using X-ray photoelectron spectroscopy (XPS). Two relatively similar pesticides, Cypermethrin and Permethrin, were used as analytes. The results showed that Au NP/MIP was competent to detect both similar molecules despite the imprint being made only by Cypermethrin. Nevertheless, Au NP/MIP has a limited number of imprinted cavities that result in sensing only low concentrations of a pesticide solution. Au NP/MIP is thus a specific design for detecting analogous molecules similar to its template structure.

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Feng, Xiaotong, Jon Ashley, Tongchang Zhou, Arnab Halder, and Yi Sun. "A facile molecularly imprinted polymer-based fluorometric assay for detection of histamine." RSC Advances 8, no. 5 (2018): 2365–72. http://dx.doi.org/10.1039/c7ra11507e.

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Li, Xiao, Yanfen He, Fan Zhao, Weiying Zhang, and Zhuoliang Ye. "Molecularly imprinted polymer-based sensors for atrazine detection by electropolymerization of o-phenylenediamine." RSC Advances 5, no. 70 (2015): 56534–40. http://dx.doi.org/10.1039/c5ra09556e.

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Zhou, Q., H. Y. Zhai, Y. F. Pan, and K. Li. "A simple and sensitive sensor based on a molecularly imprinted polymer-modified carbon paste electrode for the determination of curcumin in foods." RSC Advances 7, no. 37 (2017): 22913–18. http://dx.doi.org/10.1039/c7ra02253k.

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Wang, Peilong, Xiaohua Sun, Xiaoou Su, and Tie Wang. "Advancements of molecularly imprinted polymers in the food safety field." Analyst 141, no. 12 (2016): 3540–53. http://dx.doi.org/10.1039/c5an01993a.

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Molecularly imprinted technology (MIT) has been widely employed to produce stable, robust and cheap molecularly imprinted polymer (MIP) materials that possess selective binding sites for recognition of target analytes in food, such as pesticides, veterinary drugs, mycotoxins, illegal drugs and so on.

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Kia, Solmaz, Mohammad Fazilati, Hossain Salavati, and Shahab Bohlooli. "Preparation of a novel molecularly imprinted polymer by the sol–gel process for solid phase extraction of vitamin D3." RSC Advances 6, no. 38 (2016): 31906–14. http://dx.doi.org/10.1039/c6ra04627d.

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Zhu, Jun Feng, Guang Hua Zhang, Ting Shang, and Wei Xiong. "Synthesis and Adsorption of Molecularly Imprinted Polymers of Dibutyl Phthalate in Food." Advanced Materials Research 549 (July 2012): 340–43. http://dx.doi.org/10.4028/www.scientific.net/amr.549.340.

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In this paper, using environmental hormone dibutyl phthalate (DBP) in the contaminated foods as the template molecule, methacrylic acid (MAA) as functional monomer, ethylene glycol dimethacrylate ester (EDMA) as cross linking agent, the molecularly imprinted polymer (MIP) was prepared on the silica surface. The MIP was characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimeric analysis (TGA) and automated surface area analyzer. The property of adsorption was tested using static adsorption method in water phrase. The results of FTIR indicate that there are recognition groups in the microspheres after imprinting. TGA illustrates the silica gel surface has been coated with a layer of polymer after the synthesis reaction. And the MIP can bear the high temperature of 200 °C. The thickness of the imprinted polymer coated on silica gel surface is estimated via the pore size data is about 1. 5nm. The result of static adsorption experiment shows that the saturated adsorption capacity of the MIP was 8.940mg/g.

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Journal articles on the topic 'MIP [Moleculary imprinted polymer]'

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