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Journal articles on the topic 'MiR-202'

Author: Grafiati

Published: 22 June 2023

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1

Lin, Yilin, Zhihua Chen, Suyong Lin, et al. "MiR-202 inhibits the proliferation and invasion of colorectal cancer by targeting UHRF1." Acta Biochimica et Biophysica Sinica 51, no. 6 (2019): 598–606. http://dx.doi.org/10.1093/abbs/gmz042.

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Abstract The purpose of this study was to investigate the expression of microRNA-202 (miR-202) and its role in colorectal cancer (CRC) in vivo and in vitro. We examined the expression of miR-202 in CRC tissues by quantitative real-time PCR (qRT-PCR) assay. Lentiviral vectors were constructed to overexpress or inhibit the expression of miR-202 in the CRC cell lines HCT116 and SW480 to determine its effects on cell invasion and proliferation. We found that overexpression of miR-202 significantly inhibited the proliferation and invasion of HCT116 cells. MiRNA target gene prediction, dual lucifera

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2

Zhang, Liqing, Jianjiang Xu, Gaodi Yang, Heng Li, and Xiuxia Guo. "miR-202 Inhibits Cell Proliferation, Migration, and Invasion by Targeting Epidermal Growth Factor Receptor in Human Bladder Cancer." Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 26, no. 6 (2018): 949–57. http://dx.doi.org/10.3727/096504018x15149787144385.

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Recent studies have demonstrated that miR-202 is associated with several types of cancer; however, the expression and function of miR-202 have not been investigated in bladder cancer. We analyzed the expression of miR-202 in bladder cancer tissues and adjacent noncancerous tissues. The effect of miR-202 on the proliferation, migration, and invasion was evaluated by in vitro assays. The target gene of miR-202 was assessed by luciferase reporter assay. In this study, miR-202 was found to be significantly downregulated in bladder cancer cell lines and tissues and was highly correlated with the T

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3

Deng, Xinchao, Congzhe Hou, Zhen Liang, Huali Wang, Lin Zhu, and Hui Xu. "miR-202 Suppresses Cell Proliferation by Targeting FOXR2 in Endometrial Adenocarcinoma." Disease Markers 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/2827435.

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Background. MicroRNA-202 (miR-202) has been reported to be aberrantly regulated in several cancers. The aim of this study is to explore the functional role of miR-202 in EAC tumor growth. Material and Methods. miR-202 expression was detected by qRT-PCR. TargetScan and luciferase reporter assay were used to elucidate the candidate target gene of miR-202. The FOXR2 protein level was assessed by Western blot and immunohistochemistry. Survival analysis was explored for FOXR2 expression in EAC patients. Results. miR-202 expression was significantly decreased in EAC tissues (P<0.01) compared with

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Zhuang, Donghai, Li Liang, Hongzhan Zhang, and Xianguang Feng. "miR-202 Suppresses Hepatocellular Carcinoma Progression via Downregulating BCL2 Expression." Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 28, no. 4 (2020): 399–408. http://dx.doi.org/10.3727/096504020x15864296270581.

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miRNAs play an important role in progression of hepatocellular carcinoma (HCC). In this work, we assessed the function of miR-202 in human HCC and identified BCL2 as its target. We found miR-202 expression was found significantly downregulated, while BCL2 expression was markedly upregulated in HCC tissues and cell lines (HepG2, Hep3B, and HCCLM3). Both miR-202 and BCL2 were closely correlated with major vascular invasion and advanced TNM stage as well as overall survival of HCC patients. Overexpression of miR-202 significantly inhibited cell proliferation, induced apoptosis and cell cycle arre

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WANG, Qifeng, and Xiang Du. "Effect of microRNA-202-3p on cell proliferation and targeting of ADP-ribosylation factor-like 5A in human colorectal carcinoma." Journal of Clinical Oncology 31, no. 15_suppl (2013): e14667-e14667. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e14667.

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e14667 Background: MicroRNAs (miRNAs) are small, non-coding RNAs that are strongly implicated in cancer and reshaped our understanding of the role of non-protein-coding genes in carcinogenesis. Methods: Quantitative RT-PCR was used to evaluate miR-202-3p expression in 94 pairs of human primary CRC and adjacent noncancerous tissues (NCT) to determine the clinicopathologic significance of miR-202-3p. Cell proliferation analysis and Xenograft analysis was used to investigate miR-202-3p function in vitro and in vivo.It’s direct target ARL5A was confirmed by Luciferase assay and Western blot. Immun

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Ding, Qiang, Miaohan Jin, Yaoyue Wang та ін. "Transactivation of miR-202-5p by Steroidogenic Factor 1 (SF1) Induces Apoptosis in Goat Granulosa Cells by Targeting TGFβR2". Cells 9, № 2 (2020): 445. http://dx.doi.org/10.3390/cells9020445.

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MicroRNAs play key roles during ovary development, with emerging evidence suggesting that miR-202-5p is specifically expressed in female animal gonads. Granulosa cells (GCs) are somatic cells that are closely related to the development of female gametes in mammalian ovaries. However, the biological roles of miR-202-5p in GCs remain unknown. Here, we show that miR-202-5p is specifically expressed in GCs and accumulates in extracellular vesicles (EVs) from large growth follicles in goat ovaries. In vitro assays showed that miR-202-5p induced apoptosis and suppressed the proliferation of goat GCs

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7

Ahmed, Emad A., Peramaiyan Rajendran, and Harry Scherthan. "The microRNA-202 as a Diagnostic Biomarker and a Potential Tumor Suppressor." International Journal of Molecular Sciences 23, no. 11 (2022): 5870. http://dx.doi.org/10.3390/ijms23115870.

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MicroRNA-202 (miR-202) is a member of the highly conserved let-7 family that was discovered in Caenorhabditis elegans and recently reported to be involved in cell differentiation and tumor biology. In humans, miR-202 was initially identified in the testis where it was suggested to play a role in spermatogenesis. Subsequent research showed that miR-202 is one of the micro-RNAs that are dysregulated in different types of cancer. During the last decade, a large number of investigations has fortified a role for miR-202 in cancer. However, its functions can be double-edged, depending on context the

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8

Kim, Jungho, Sunyoung Park, Dasom Hwang, Seung Il Kim, and Hyeyoung Lee. "Diagnostic Value of Circulating miR-202 in Early-Stage Breast Cancer in South Korea." Medicina 56, no. 7 (2020): 340. http://dx.doi.org/10.3390/medicina56070340.

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Background and objectives: Breast cancer is the most common cancer among women worldwide. Early stage diagnosis is important for predicting increases in treatment success rates and decreases in patient mortality. Recently, circulating biomarkers such as circulating tumor cells, circulating tumor DNA, exosomes, and circulating microRNAs have been examined as blood-based markers for the diagnosis of breast cancer. Although miR-202 has been studied for its function or expression in breast cancer, its potential diagnostic value in a clinical setting remains elusive and miR-202 has not been investi

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Mo, Chengyu, Wenjing Li, Kuntong Jia, Wei Liu, and Meisheng Yi. "Proper Balance of Small GTPase rab10 Is Critical for PGC Migration in Zebrafish." International Journal of Molecular Sciences 22, no. 21 (2021): 11962. http://dx.doi.org/10.3390/ijms222111962.

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MicroRNAs (miRNAs) play important roles in post-transcriptional repression in nearly every biological process including germ cell development. Previously, we have identified a zebrafish germ plasm-specific miRNA miR-202-5p, which regulates PGC migration through targeting cdc42se1 to protect cdc42 expression. However, knockdown of cdc42se1 could not significantly rescue PGC migration in maternal miR-202 mutant (MmiR-202) embryos, indicating that there are other target genes of miR-202-5p required for the regulation of PGC migration. Herein, we revealed the transcriptional profiles of wild type

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Sun, Wei, Wei Ping, Yitao Tian, Wenbin Zou, Jiawei Liu, and Yukun Zu. "miR-202 Enhances the Anti-Tumor Effect of Cisplatin on Non-Small Cell Lung Cancer by Targeting the Ras/MAPK Pathway." Cellular Physiology and Biochemistry 51, no. 5 (2018): 2160–71. http://dx.doi.org/10.1159/000495835.

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Background/Aims: KRas is usually mutated in non-small cell lung cancer (NSCLC). The mutated KRas gene is a negative prognostic indicator that promotes tumor proliferation, metastasis, and drug resistance in NSCLC, and thus has become a target for cancer therapy. This study is focused on the effects of the microRNA (miR)-202/KRas axis in regulating chemosensitivity in NSCLC. Methods: Quantitative reverse transcriptase real-time PCR analysis was performed to examine the expression of miR-202. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays were performed to evaluate the

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Wei, Xiaoling, Lingjun Dong, and Xiubing Lei. "LncRNA NORAD/miR 202 5p regulates hepatoma cell viability, apoptosis via EGFR/PI3K/AKT signaling pathway." Tropical Journal of Pharmaceutical Research 22, no. 4 (2023): 749–57. http://dx.doi.org/10.4314/tjpr.v22i4.6.

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Purpose: To examine the potential modulatory mechanisms of NORAD in hepatoma in vitro.  Methods: In this study, four human hepatoma cell lines (Bel7404, PLC5, HepG2, and HuH7), as well as a human immortalized Normal MIHA cell line were employed. Transfection was performed to up-or down-regulate NORAD and miR-202-5p expression in cells. RT-qPCR was used to measure expressions of NORAD, miR-202-5p, and biomarkers for cell cycle and apoptosis in HCC cell lines. CCK-8, Flow Cytometry for apoptosis and cell cycle arrest and Western blot experiments were performed to determine cellular viabili

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12

Chen, Yueyao, Shiqun Zhou, and Haixiang Li. "Changes of Serum miR-202-3p Level and Its Correlation with Prognosis in Patients with Acute Kidney Injury Induced by Sepsis." Tobacco Regulatory Science 7, no. 4 (2021): 674–82. http://dx.doi.org/10.18001/trs.7.4.1.20.

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To investigate the changes of serum miR-202-3p level and its correlation with prognosis in patients with acute kidney injury (AKI) induced by sepsis. From April 2017 to January 2019, 66 patients with AKI induced by sepsis in our hospital and 70 healthy people in the same period were selected as the research objects. The levels of miR-202-3p, BUN and Cr in serum were tested. Subsequently, cell experiments were carried out to verify the effects of the decrease of miR-202-3p level on BUN, Cr and cell growth and apoptosis. The risk factors were analysed. Compared with healthy volunteers, patients

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13

Liu, Wei, Yilin Jin, Wanwan Zhang, et al. "MiR-202-5p Inhibits RIG-I-Dependent Innate Immune Responses to RGNNV Infection by Targeting TRIM25 to Mediate RIG-I Ubiquitination." Viruses 12, no. 3 (2020): 261. http://dx.doi.org/10.3390/v12030261.

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The RIG-I-like receptors (RLRs) signaling pathway is essential for inducing type I interferon (IFN) responses to viral infections. Meanwhile, it is also tightly regulated to prevent uncontrolled immune responses. Numerous studies have shown that microRNAs (miRNAs) are essential for the regulation of immune processes, however, the detailed molecular mechanism of miRNA regulating the RLRs signaling pathway remains to be elucidated. Here, our results showed that miR-202-5p was induced by red spotted grouper nervous necrosis virus (RGNNV) infection in zebrafish. Overexpression of miR-202-5p led to

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Ran, Mingxia, Shenqiang Hu, Qingyuan Ouyang, et al. "miR-202-5p Inhibits Lipid Metabolism and Steroidogenesis of Goose Hierarchical Granulosa Cells by Targeting ACSL3." Animals 13, no. 3 (2023): 325. http://dx.doi.org/10.3390/ani13030325.

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miRNAs are critical for steroidogenesis in granulosa cells (GCs) during ovarian follicular development. We have previously shown that miR-202-5p displays a stage-dependent expression pattern in GCs from goose follicles of different sizes, suggesting that this miRNA could be involved in the regulation of the functions of goose GCs; therefore, in this study, the effects of miR-202-5p on lipid metabolism and steroidogenesis in goose hierarchical follicular GCs (hGCs), as well as its mechanisms of action, were evaluated. Oil Red O staining and analyses of intracellular cholesterol and triglyceride

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Feng, Guanghang, Jie Liu, Zitao Lu, et al. "miR-450-5p and miR-202-5p Synergistically Regulate Follicle Development in Black Goat." International Journal of Molecular Sciences 24, no. 1 (2022): 401. http://dx.doi.org/10.3390/ijms24010401.

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Follicle maturation is a complex biological process governed by numerous factors, and researchers have observed follicle development by studying the proliferation and apoptosis of follicular granulosa cells (GCs). However, the regulatory mechanisms of GCs proliferation and death during follicle development are largely unknown. To investigate the regulatory mechanisms of lncRNAs, mRNAs, and microRNAs, RNA sequencing (RNA-seq) and small RNA-seq were performed on large (>10 mm) and small follicles (<3 mm) of Leizhou black goat during estrus. We discovered two microRNAs, miR-450-5p and miR-2

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Ran, Mingxia, Shenqiang Hu, Hengli Xie, et al. "MiR-202-5p Regulates Geese Follicular Selection by Targeting BTBD10 to Regulate Granulosa Cell Proliferation and Apoptosis." International Journal of Molecular Sciences 24, no. 7 (2023): 6792. http://dx.doi.org/10.3390/ijms24076792.

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The regulation of granulosa cells (GCs) proliferation and apoptosis is the key step in follicular selection which determines the egg production performance of poultry. miR-202-5p has been reported to be involved in regulating the proliferation and apoptosis of mammalian ovarian GCs. However, its role in regulating the proliferation and apoptosis of goose GCs is still unknown. In the present study, the GCs of pre-hierarchical follicles (phGCs, 8–10 mm) and those of hierarchical follicles (hGCs, F2–F4) were used to investigate the role of miR-202-5p in cell proliferation and apoptosis during fol

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Zheng, Li, Dai Fei Sun, and Yanyan Tong. "Exosomal miR-202 derived from leukorrhea as a potential biomarker for endometriosis." Journal of International Medical Research 51, no. 1 (2023): 030006052211471. http://dx.doi.org/10.1177/03000605221147183.

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Objective Endometriosis (EMS) is a chronic gynecological disorder with an urgent need of a reliable non-invasive diagnostic strategy. Recently, there has been increasing interest in using the contents of exosomes, especially exosomal microRNAs (miRNAs), as potential biomarkers for various types of diseases. In this study, we assessed the differentially expressed miRNAs in exosomes derived from primary normal and ectopic endometrial cells. Methods We used miRNA microarray analysis to identify differentially expressed exosomal miRNAs. Among the selected exosomal miRNAs, we focused on hsa-miR-202

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Monastirioti, Alexia, Chara Papadaki, Konstantinos Rounis, Despoina Kalapanida, Dimitrios Mavroudis, and Sofia Agelaki. "A Prognostic Role for Circulating microRNAs Involved in Macrophage Polarization in Advanced Non-Small Cell Lung Cancer." Cells 10, no. 8 (2021): 1988. http://dx.doi.org/10.3390/cells10081988.

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Circulating microRNAs (miRNAs) are key regulators of the crosstalk between tumor cells and immune response. In the present study, miRNAs (let-7c, miR-26a, miR-30d, miR-98, miR-195, miR-202) reported to be involved in the polarization of macrophages were examined for associations with the outcomes of non-small cell lung cancer (NSCLC) patients (N = 125) treated with first-line platinum-based chemotherapy. RT-qPCR was used to analyze miRNA expression levels in the plasma of patients prior to treatment. In our results, disease progression was correlated with high miR-202 expression (HR: 2.335; p

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Jin, Yilin, Wei Liu, Yangxi Xiang, et al. "Maternal miR-202-5p is required for zebrafish primordial germ cell migration by protecting small GTPase Cdc42." Journal of Molecular Cell Biology 12, no. 7 (2019): 530–42. http://dx.doi.org/10.1093/jmcb/mjz103.

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Abstract In many lower animals, germ cell formation, migration, and maintenance depend on maternally provided determinants in germ plasm. In zebrafish, these processes have been extensively studied in terms of RNA-binding proteins and other coding genes. The role of small non-coding RNAs in the regulation of primordial germ cell (PGC) development remains largely unknown and poorly investigated, even though growing interests for the importance of miRNAs involved in a wide variety of biological processes. Here, we reported the role and mechanism of the germ plasm-specific miRNA miR-202-5p in PGC

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Zhao, Wei, Youyang Wu, Fanhao Ye, et al. "Tetrandrine Ameliorates Myocardial Ischemia Reperfusion Injury through miR-202-5p/TRPV2." BioMed Research International 2021 (March 8, 2021): 1–16. http://dx.doi.org/10.1155/2021/8870674.

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Objective. This study is aimed at investigating the therapeutic effects of tetrandrine (Tet) on myocardial ischemia reperfusion (I/R) injury and probe into underlying molecular mechanism. Methods. H9C2 cells were divided into hypoxia/oxygenation (H/R) group, H/R+Tet group, H/R+Tet+negative control (NC) group, and H/R+Tet+miR-202-5p inhibitor group. RT-qPCR was utilized to monitor miR-202-5p and TRPV2 expression, and TRPV2 protein expression was detected via western blot and immunohistochemistry in H9C2 cells. Cardiomyocyte apoptosis was evaluated through detection of apoptosis-related markers

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Zhang, Jie, Xiao-Yan Li, Ping Hu, and Yuan-Sheng Ding. "lncRNA NORAD Contributes to Colorectal Cancer Progression by Inhibition of miR-202-5p." Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 26, no. 9 (2018): 1411–18. http://dx.doi.org/10.3727/096504018x15190844870055.

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Previous study indicates that long noncoding RNA NORAD could serve as a competing endogenous RNA to pancreatic cancer metastasis. However, its role in colorectal cancer (CRC) needs to be investigated. In the present study, we found that the expression of NORAD was significantly upregulated in CRC tissues. Furthermore, the expression of NORAD was positively related with CRC metastasis and patients’ poor prognosis. Knockdown of NORAD markedly inhibited CRC cell proliferation, migration, and invasion but induced cell apoptosis in vitro. In vivo experiments also indicated an inhibitory effect of N

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22

Xu, Wenjing, Liwei Xie, Yingying Yang, Jiayu Xu, Shang Cai, and Ye Tian. "KAT5 Inhibitor NU9056 Suppresses Anaplastic Thyroid Carcinoma Progression through c-Myc/miR-202 Pathway." International Journal of Endocrinology 2022 (February 11, 2022): 1–14. http://dx.doi.org/10.1155/2022/2014568.

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Background. Anaplastic thyroid carcinoma (ATC) is considered to be one of the most aggressive cancers. Our previous study proved that highly expressed lysine acetyltransferase 5 (KAT5) in ATC is associated with a poorer prognosis. Here, this study examined the effects of a KAT5 inhibitor (NU9056) in human ATC cells. Methods. First, the Cancer Genome Atlas (TCGA) dataset was used to detect the relationship between KAT5 expression and outcomes of thyroid carcinoma patients. Then, both in vitro and in vivo experiments were conducted to investigate the effects of NU9056 on normal and ATC human thy

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Marisaldi, Luca, Orsola Iorillo, Danilo Basili, et al. "A Comparison of Reproductive Performances in Young and Old Females: A Case Study on the Atlantic Bluefin Tuna in the Mediterranean Sea." Animals 11, no. 12 (2021): 3340. http://dx.doi.org/10.3390/ani11123340.

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In the Mediterranean Sea, a demographic substructure of the Atlantic bluefin tuna Thunnus thynnus has emerged over the last decade, with old and young individuals exhibiting different horizontal movements and spatial–temporal patterns of gonad maturation. In the present study, histology and molecular reproductive markers were integrated with the gonad-specific mir-202 gene expression and ovarian localization to provide a comprehensive picture of the reproductive performances in young and old females and investigate the role played by the mir-202 during gonadal maturation. During the reproducti

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Sontakke, Sadanand D., Bushra T. Mohammed, Alan S. McNeilly, and F. Xavier Donadeu. "Characterization of microRNAs differentially expressed during bovine follicle development." REPRODUCTION 148, no. 3 (2014): 271–83. http://dx.doi.org/10.1530/rep-14-0140.

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Several different miRNAs have been proposed to regulate ovarian follicle function; however, very limited information exists on the spatiotemporal patterns of miRNA expression during follicle development. The objective of this study was to identify, using microarray, miRNA profiles associated with growth and regression of dominant-size follicles in the bovine monovular ovary and to characterize their spatiotemporal distribution during development. The follicles were collected from abattoir ovaries and classified as small (4–8 mm) or large (12–17 mm); the latter were further classified as health

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Donadeu, F. X., S. D. Sontakke, and J. Ioannidis. "MicroRNA indicators of follicular steroidogenesis." Reproduction, Fertility and Development 29, no. 5 (2017): 906. http://dx.doi.org/10.1071/rd15282.

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MicroRNAs (miRNAs) can provide useful biomarkers of tissue function. The aim of the present study was to determine, in bovine follicles (n = 66; diameter 4–22 mm), the relationship among several indices of steroidogenesis and levels of 15 miRNAs previously identified to be associated with follicle development. Oestradiol levels, the oestradiol : progesterone (E : P) ratio and cytochrome P450 family 19 subfamily A member 1 (CYP19A1) expression were strongly correlated with each other (ρ > 0.8) and with LH/choriogonadotropin receptor (LHCGR) expression (ρ ≥ 0.6; P < 0.01). Levels of nine d

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Su, Yan, Shiyou Lu, Jincun Li, and Liya Deng. "Shikonin-mediated up-regulation of miR-34a and miR-202 inhibits retinoblastoma proliferation." Toxicology Research 7, no. 5 (2018): 907–12. http://dx.doi.org/10.1039/c8tx00079d.

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Gay, Stéphanie, Jérôme Bugeon, Amine Bouchareb, et al. "MiR-202 controls female fecundity by regulating medaka oogenesis." PLOS Genetics 14, no. 9 (2018): e1007593. http://dx.doi.org/10.1371/journal.pgen.1007593.

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Bizuayehu, Teshome Tilahun, and Igor Babiak. "Heterogenic Origin of Micro RNAs in Atlantic Salmon (Salmo salar) Seminal Plasma." International Journal of Molecular Sciences 21, no. 8 (2020): 2723. http://dx.doi.org/10.3390/ijms21082723.

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The origin and contribution of seminal plasma RNAs into the whole semen RNA repertoire are poorly known, frequently being overlooked or neglected. In this study, we used high-throughput sequencing and RT-qPCR to profile microRNA (miRNA) constituents in the whole semen, as well as in fractionated spermatozoa and seminal plasma of Atlantic salmon (Salmo salar). We found 85 differentially accumulated miRNAs between spermatozoa and the seminal plasma. We identified a number of seminal plasma-enriched and spermatozoa-enriched miRNAs. We localized the expression of some miRNAs in juvenile and mature

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Lagah, S., T. J. Sood, P. Palta, et al. "32 NEXT-GENERATION SEQUENCING DISCLOSES DIFFERENCES IN microRNA EXPRESSION PROFILES OF BUFFALO (BUBALUS BUBALIS) EMBRYOS PRODUCED BY HAND-MADE CLONING AND IN VITRO FERTILIZATION." Reproduction, Fertility and Development 29, no. 1 (2017): 123. http://dx.doi.org/10.1071/rdv29n1ab32.

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Mammalian embryo development is a complex process with a series of critical events taking place at every stage of development. It is an established fact that the birth rate of animals produced by nuclear transfer (NT) is far less (<2%) than that of IVF embryos (40%) after successful embryo transfers in different farm animal species. Micro(mi)RNAs are small non-coding RNAs of 17 to 25 nucleotides that alter the function of their target genes by either degrading them or inhibiting their expression. MiRNAs play a vital role during mammalian embryo development and may be adding to the extremely

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Schaefer, Jeremy, Niyati Nakra, Dina Montufar-Solis, Nadarajah Vigneswaran, and John Klein. "P-202 IL-10 Mediated Regulation of miR-223 and Roquin." Inflammatory Bowel Diseases 19 (December 2013): S106. http://dx.doi.org/10.1097/01.mib.0000439001.00060.21.

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Lee, Soon-Tae, Kon Chu, Keun-Hwa Jung, et al. "Altered Expression of miR-202 in Cerebellum of Multiple-System Atrophy." Molecular Neurobiology 51, no. 1 (2014): 180–86. http://dx.doi.org/10.1007/s12035-014-8788-4.

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Fang, Baojun, Limin Wei, Kejun Dong, Xiaohui Niu, Xiuhui Sui, and Hongquan Zhang. "miR‐202 modulates the progression of neuropathic pain through targeting RAP1A." Journal of Cellular Biochemistry 120, no. 3 (2018): 2973–82. http://dx.doi.org/10.1002/jcb.27025.

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Czop, Marcin, Karolina Gasińska, Ewa Kosior-Jarecka, Dominika Wróbel-Dudzińska, Janusz Kocki, and Tomasz Żarnowski. "Twenty Novel MicroRNAs in the Aqueous Humor of Pseudoexfoliation Glaucoma Patients." Cells 12, no. 5 (2023): 737. http://dx.doi.org/10.3390/cells12050737.

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The microRNAs (miRNAs) are short non-coding RNAs (19–25 nt) that regulate the level of gene expression at the post-transcriptional stage. Altered miRNAs expression can lead to the development of various diseases, e.g., pseudoexfoliation glaucoma (PEXG). In this study, we assessed the levels of miRNA expression in the aqueous humor of PEXG patients using the expression microarray method. Twenty new miRNA molecules have been selected as having the potential to be associated with the development or progression of PEXG. Ten miRNAs were downregulated in PEXG (hsa-miR-95-5p, hsa-miR-515-3p, hsa-mir-

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Li, Wenjun, Xuechao Xu, Yixin Wan, Hong Wang, Hongyan Tao, and Huirong Huang. "Cynaropicrin inhibits lung cancer proliferation by targeting EGFR/AKT signaling pathway." Tropical Journal of Pharmaceutical Research 20, no. 4 (2022): 715–20. http://dx.doi.org/10.4314/tjpr.v20i4.8.

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    Purpose: To investigate the anti-proliferative effect of cynaropicrin on lung cancer cell lines, and the underlying molecular mechanism. Methods: The effect of cynaropicrin treatment on the viabilities of H1975 and H460 cells was measured using Cell Counting Kit-8. Apoptosis was analysed by annexin-V/FITC staining, while protein expressions were assayed by western blotting. Results: Treatment of H1975 and H460 cells with cynaropicrin at doses of 0.25 – 2.0 μM led to a marked reduction in their viability (p < 0.05). In cynaropicrin-treated H1975 and H4

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Li, Jin, Baohua Zhang, Qihuang Chen, and Qiang Li. "miR-202 Mediates Metabolic Shift in Lung Cancer Cells via Targeting HK2." Current Signal Transduction Therapy 9, no. 2 (2015): 101–5. http://dx.doi.org/10.2174/1574362410666150107234535.

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Wang, Li, Xueyan Liu, Xicheng Song, Lei Dong, and Dawei Liu. "MiR-202-5p Promotes M2 Polarization in Allergic Rhinitis by Targeting MATN2." International Archives of Allergy and Immunology 178, no. 2 (2018): 119–27. http://dx.doi.org/10.1159/000493803.

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Li, Shizhu, Genmei Lin, Wenyu Fang, et al. "Identification and Comparison of microRNAs in the Gonad of the Yellowfin Seabream (Acanthopagrus Latus)." International Journal of Molecular Sciences 21, no. 16 (2020): 5690. http://dx.doi.org/10.3390/ijms21165690.

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Yellowfin seabream (Acanthopagrus latus) is a commercially important fish in Asian coastal waters. Although natural sex reversal has been described in yellowfin seabream, the mechanisms underlying sexual differentiation and gonadal development in this species remain unclear. MicroRNAs (miRNAs) have been shown to play crucial roles in gametogenesis and gonadal development. Here, two libraries of small RNAs, constructed from the testes and ovaries of yellowfin seabream, were sequenced. Across both gonads, we identified 324 conserved miRNAs and 92 novel miRNAs: 67 ovary-biased miRNAs, including t

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Shang, Zhiwei, and Hongwen Li. "Altered expression of four miRNA (miR-1238-3p, miR-202-3p, miR-630 and miR-766-3p) and their potential targets in peripheral blood from vitiligo patients." Journal of Dermatology 44, no. 10 (2017): 1138–44. http://dx.doi.org/10.1111/1346-8138.13886.

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Santos, Nathalia L., Silvina O. Bustos, Patricia P. Reis, Roger Chammas, and Luciana N. S. Andrade. "Extracellular Vesicle-Packaged miR-195-5p Sensitizes Melanoma to Targeted Therapy with Kinase Inhibitors." Cells 12, no. 9 (2023): 1317. http://dx.doi.org/10.3390/cells12091317.

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Management of advanced melanoma remains challenging, with most BRAF (B-Raf proto-oncogene, serine/threonine kinase)-mutated metastatic patients relapsing within a few months upon MAPK inhibitors treatment. Modulation of tumor-derived extracellular vesicle (EVs) cargo with enrichment of antitumoral molecules is a promising strategy to impair tumor progression and increase treatment response. Herein, we report that restored expression of miR-195-5p, down-regulated in melanoma favoring drug resistance, increases the release of EVs enriched in the tumor suppressor miRNAs, miR-195-5p, miR-152-3p, a

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Poel, Boyd, Beekhof, et al. "Proteomic Analysis of miR-195 and miR-497 Replacement Reveals Potential Candidates that Increase Sensitivity to Oxaliplatin in MSI/P53wt Colorectal Cancer Cells." Cells 8, no. 9 (2019): 1111. http://dx.doi.org/10.3390/cells8091111.

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Most patients with advanced colorectal cancer (CRC) eventually develop resistance to systemic combination therapy. miR-195-5p and miR-497-5p are downregulated in CRC tissues and associated with drug resistance. Sensitization to 5-FU, oxaliplatin, and irinotecan by transfection with miR-195-5p and miR-497-5p mimics was studied using cell viability and clonogenic assays in cell lines HCT116, RKO, DLD-1, and SW480. In addition, proteomic analysis of transfected cells was implemented to identify potential targets. Significantly altered proteins were subjected to STRING (protein-protein interaction

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Meng, Xiangrui, Xiaoqi Chen, Peng Lu, et al. "miR-202 Promotes Cell Apoptosis in Esophageal Squamous Cell Carcinoma by Targeting HSF2." Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 25, no. 2 (2017): 215–23. http://dx.doi.org/10.3727/096504016x14732772150541.

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Hoffman, Aaron E., Ran Liu, Alan Fu, Tongzhang Zheng, Frank Slack, and Yong Zhu. "Targetome Profiling, Pathway Analysis and Genetic Association Study Implicate miR-202 in Lymphomagenesis." Cancer Epidemiology Biomarkers & Prevention 22, no. 3 (2013): 327–36. http://dx.doi.org/10.1158/1055-9965.epi-12-1131-t.

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Zhao, Yu, Chenglong Li, Ming Wang, et al. "Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer." PLoS ONE 8, no. 7 (2013): e69756. http://dx.doi.org/10.1371/journal.pone.0069756.

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Lin, Yilin, Zhihua Chen, Suyong Lin, et al. "MiR-202 inhibits the proliferation and invasion of colorectal cancer by targeting UHRF1." Acta Biochimica et Biophysica Sinica 51, no. 12 (2019): 1305–6. http://dx.doi.org/10.1093/abbs/gmz088.

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Amini Khorasgani, Majid, Parisa Mohammady Nejad, and Mohammad Mehdi Moghani Bashi. "Increased Expression of miR-202-3p in Patients with Relapsing-Remitting Multiple Sclerosis." Jorjani Biomedicine Journal 6, no. 4 (2018): 8–18. http://dx.doi.org/10.29252/jorjanibiomedj.6.4.8.

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Mody, Hardik R., Sau Wai Hung, Rakesh K. Pathak, Jazmine Griffin, Zobeida Cruz-Monserrate та Rajgopal Govindarajan. "miR-202 Diminishes TGFβ Receptors and Attenuates TGFβ1-Induced EMT in Pancreatic Cancer". Molecular Cancer Research 15, № 8 (2017): 1029–39. http://dx.doi.org/10.1158/1541-7786.mcr-16-0327.

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Sun, Zhengwen, Tongqing Zhang, Huanyu Hong, Qingxia Liu, and Haiguang Zhang. "miR-202 suppresses proliferation and induces apoptosis of osteosarcoma cells by downregulating Gli2." Molecular and Cellular Biochemistry 397, no. 1-2 (2014): 277–83. http://dx.doi.org/10.1007/s11010-014-2195-z.

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Huang, Zong-Sheng, Xian-Wen Guo, Guo Zhang, Lie-Xin Liang, and Bing Nong. "The Diagnostic and Prognostic Value of miR-200c in Gastric Cancer: A Meta-Analysis." Disease Markers 2019 (April 4, 2019): 1–9. http://dx.doi.org/10.1155/2019/8949618.

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Background. The role of miR-200c in gastric cancer remains controversial. This study is aimed at clarifying the diagnostic and prognostic value of miR-200c in gastric cancer through a meta-analysis. Methods. A comprehensive literature search of PubMed, Embase, and Ovid library databases was conducted. The studies included were those conducted before December 2017. The sensitivity and specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under curve (AUC) were used to estimate the diagnostic value of miR-200c. Meanwhile, the pooled

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Raveche, Elizabeth S., Erica Salerno, Brian J. Scaglione, et al. "Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice." Blood 109, no. 12 (2007): 5079–86. http://dx.doi.org/10.1182/blood-2007-02-071225.

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Abstract New Zealand black (NZB) mice with autoimmune and B lymphoproliferative disease (B-LPD) are a model for human chronic lymphocytic leukemia (CLL). A genomewide linkage scan of the NZB loci associated with lymphoma was conducted in F1 backcrosses of NZB and a control strain, DBA/2. Of 202 mice phenotyped for the presence or absence of LPD, surface maker expression, DNA content, and microsatellite polymorphisms, 74 had disease. The CD5+, IgM+, B220dim, hyperdiploid LPD was linked to 3 loci on chromosomes 14, 18, and 19 that are distinct from previously identified autoimmunity-associated l

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Dou, Dou, Yan-Fen Shi, Qing Liu, et al. "Hsa-miR-202-3p, up-regulated in type 1 gastric neuroendocrine neoplasms, may targetDUSP1." World Journal of Gastroenterology 24, no. 5 (2018): 573–82. http://dx.doi.org/10.3748/wjg.v24.i5.573.

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