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Journal articles on the topic 'MiRNA hcmv'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Waters, Shelley, Silvia Lee, Kylie Munyard, Ashley Irish, Patricia Price, and Bing H. Wang. "Human Cytomegalovirus-Encoded microRNAs Can Be Found in Saliva Samples from Renal Transplant Recipients." Non-Coding RNA 6, no. 4 (2020): 50. http://dx.doi.org/10.3390/ncrna6040050.

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Human cytomegalovirus (HCMV) infections are common following renal transplantation and may have long-lasting effects. HCMV can be measured directly by viral DNA or indirectly via host immune responses. HCMV-encoded microRNA (miRNA) may alter the pathobiology of HCMV infections and contribute to the progression of HCMV disease. HCMV-encoded miRNAs can be detected in blood but have not been sought in saliva. We investigated saliva samples from 32 renal transplant recipients (RTR) and 12 seropositive healthy controls for whom immunological data was available. Five HCMV-encoded miRNAs (miR-UL112-5

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Melaiu, Ombretta, Silvia D’Amico, Patrizia Tempora, Valeria Lucarini, and Doriana Fruci. "Impact of Natural Occurring ERAP1 Single Nucleotide Polymorphisms within miRNA-Binding Sites on HCMV Infection." International Journal of Molecular Sciences 21, no. 16 (2020): 5861. http://dx.doi.org/10.3390/ijms21165861.

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Human cytomegalovirus (HCMV) is a β-herpesvirus that causes serious problems in people with a compromised immune system, whereas it coexists asymptomatically within the host with a healthy immune system. Like other viruses, HCMV has adopted multiples strategies to manipulate the host’s immune responses. Among them, expression of viral microRNAs (miRNAs) is one of the most intriguing. HCMV miR-UL112-5p and miR-US4-1 have been found to contribute to immune evasion by targeting the endoplasmic reticulum aminopeptidase 1 (ERAP1), a highly polymorphic key component of antigen processing. The curren

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Lazzari, Elisabetta, Gabriella Rozera, Rozenn Esvan, et al. "Expression of HCMV-Encoded miRNA in Subjects Acutely Coinfected with HIV: Correlation with Inflammation and Immune Activation." International Journal of Molecular Sciences 26, no. 12 (2025): 5673. https://doi.org/10.3390/ijms26125673.

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Human cytomegalovirus (HCMV) coinfection is associated with a faster HIV disease progression and adverse clinical outcomes. HCMV-encoded miRNA expression, in individuals acutely infected with HIV (AHI), compared to those with HCMV monoinfection, was investigated in relation to viral replication and inflammation/immune activation. Sixteen individuals with AHI coinfected with HCMV were analyzed at serodiagnosis (T0) and after 6 (T1) and 12 (T2) months of antiretroviral therapy initiated within one week from serodiagnosis. Fourteen HCMV monoinfected subjects were also studied. Plasma RNA was reve

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Poole, Emma, Stuart R. McGregor Dallas, Julia Colston, Robert Samuel V. Joseph, and John Sinclair. "Virally induced changes in cellular microRNAs maintain latency of human cytomegalovirus in CD34+ progenitors." Journal of General Virology 92, no. 7 (2011): 1539–49. http://dx.doi.org/10.1099/vir.0.031377-0.

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One site of latency of human cytomegalovirus (HCMV; human herpesvirus 5) is known to be CD34+ haematopoietic progenitor cells, and it is likely that carriage of latent virus has profound effects on cellular gene expression in order to optimize latency and reactivation. As microRNAs (miRNAs) play important roles in regulating stem-cell gene expression, this study asked whether latent carriage of HCMV led to changes in cellular miRNA expression. A comprehensive miRNA screen showed the differential regulation of a number of cellular miRNAs during HCMV latency in CD34+ progenitor cells. One of the

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Diggins, Nicole, and Meaghan Hancock. "HCMV miRNA Targets Reveal Important Cellular Pathways for Viral Replication, Latency, and Reactivation." Non-Coding RNA 4, no. 4 (2018): 29. http://dx.doi.org/10.3390/ncrna4040029.

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It is now well appreciated that microRNAs (miRNAs) play a critical role in the lifecycles of many herpes viruses. The human cytomegalovirus (HCMV) replication cycle varies significantly depending on the cell type infected, with lytic replication occurring in fully-differentiated cells such as fibroblasts, endothelial cells, or macrophages, and latent infection occurring in less-differentiated CD14+ monocytes and CD34+ hematopoietic progenitor cells where viral gene expression is severely diminished and progeny virus is not produced. Given their non-immunogenic nature and their capacity to targ

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Stern-Ginossar, Noam, Niveen Saleh, Miri D. Goldberg, Mark Prichard, Dana G. Wolf, and Ofer Mandelboim. "Analysis of Human Cytomegalovirus-Encoded MicroRNA Activity during Infection." Journal of Virology 83, no. 20 (2009): 10684–93. http://dx.doi.org/10.1128/jvi.01292-09.

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ABSTRACT MicroRNAs (miRNAs) are expressed in a wide variety of organisms, ranging from plants to animals, and are key posttranscriptional regulators of gene expression. Virally encoded miRNAs are unique in that they could potentially target both viral and host genes. Indeed, we have previously demonstrated that a human cytomegalovirus (HCMV)-encoded miRNA, miR-UL112, downregulates the expression of a host immune gene, MICB. Remarkably, it was shown that the same miRNA also downregulates immediate-early viral genes and that its ectopic expression resulted in reduced viral replication and viral

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7

Pandeya, Abhishek, Raj Kumar Khalko, Sukhveer Singh, Manish Kumar, and Sunil Babu Gosipatala. "Hcmv-miR-UL148D regulates the staurosporine-induced apoptosis by targeting the Endoplasmic Reticulum to Nucleus signaling 1(ERN1)." PLOS ONE 17, no. 9 (2022): e0275072. http://dx.doi.org/10.1371/journal.pone.0275072.

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The propensity of viruses to co-opt host cellular machinery by reprogramming the host’s RNA-interference machinery has been a major focus of research, however, regulation of host defense mechanisms by virus-encoded miRNA, is an additional regulatory realm gaining momentum in the arena of host-viral interactions. The Human Cytomegalovirus (HCMV) miRNAs, regulate many cellular pathways alone or in concordance with HCMV proteins, thereby paving a conducive environment for successful infection in the human host. We show that HCMV miRNA, hcmv-miR-UL148D inhibits staurosporine-induced apoptosis in H

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8

Wang, Fu-Zhang, Frank Weber, Carlo Croce, Chang-Gong Liu, Xudong Liao, and Philip E. Pellett. "Human Cytomegalovirus Infection Alters the Expression of Cellular MicroRNA Species That Affect Its Replication." Journal of Virology 82, no. 18 (2008): 9065–74. http://dx.doi.org/10.1128/jvi.00961-08.

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ABSTRACT The human genome encodes over 500 microRNAs (miRNAs), small RNAs (19 to 26 nucleotides [nt]) that regulate the expressions of diverse cellular genes. Many cellular processes are altered through a variety of mechanisms by human cytomegalovirus (HCMV) infection. We asked whether HCMV infection leads to changes in the expression of cellular miRNAs and whether HCMV-regulated miRNAs are important for HCMV replication. Levels of most miRNAs did not change markedly during infection, but some were positively or negatively regulated. Patterns of miRNA expression were linked to the time course

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Yu, Mengyao, Yuexinzi Jin, Shichang Zhang, Jian Xu, and Jiexin Zhang. "microRNA, a Subtle Indicator of Human Cytomegalovirus against Host Immune Cells." Vaccines 10, no. 2 (2022): 144. http://dx.doi.org/10.3390/vaccines10020144.

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Human cytomegalovirus (HCMV) is a double-stranded DNA virus that belongs to the β-herpesvirus family and infects 40–90% of the adult population worldwide. HCMV infection is usually asymptomatic in healthy individuals but causes serious problems in immunocompromised people. We restricted this narrative review (PubMed, January 2022) to demonstrate the interaction and molecular mechanisms between the virus and host immune cells with a focus on HCMV-encoded miRNAs. We found a series of HCMV-encoded miRNAs (e.g., miR-UL112 and miR-UL148D) are explicitly involved in the regulation of viral DNA repli

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Soffritti, Irene, Maria D’Accolti, Clara Maccari, et al. "Coinfection of Dermal Fibroblasts by Human Cytomegalovirus and Human Herpesvirus 6 Can Boost the Expression of Fibrosis-Associated MicroRNAs." Microorganisms 11, no. 2 (2023): 412. http://dx.doi.org/10.3390/microorganisms11020412.

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Tissue fibrosis can affect every type of tissue or organ, often leading to organ malfunction; however, the mechanisms involved in this process are not yet clarified. A role has been hypothesized for Human Cytomegalovirus (HCMV) and Human Herpesvirus 6 (HHV-6) infections as triggers of systemic sclerosis (SSc), a severe autoimmune disease causing progressive tissue fibrosis, since both viruses and antiviral immune responses toward them have been detected in patients. Moreover, HCMV or HHV-6A infection was reported to increase the expression of fibrosis-associated transcriptional factors and miR

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Soffritti, Irene, Maria D’Accolti, Francesca Bini, et al. "Virus-Induced MicroRNA Modulation and Systemic Sclerosis Disease." Biomedicines 12, no. 6 (2024): 1360. http://dx.doi.org/10.3390/biomedicines12061360.

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MicroRNAs (miRNAs) are short noncoding RNA sequences that regulate gene expression at the post-transcriptional level. They are involved in the regulation of multiple pathways, related to both physiological and pathological conditions, including autoimmune diseases, such as Systemic Sclerosis (SSc). Specifically, SSc is recognized as a complex and multifactorial disease, characterized by vascular abnormalities, immune dysfunction, and progressive fibrosis, affecting skin and internal organs. Among predisposing environmental triggers, evidence supports the roles of oxidative stress, chemical age

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Diggins, Nicole L., Andrew H. Pham, Jennifer Mitchell, et al. "Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice." PLOS Pathogens 20, no. 12 (2024): e1012285. https://doi.org/10.1371/journal.ppat.1012285.

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Human cytomegalovirus (HCMV) actively manipulates cellular signaling pathways to benefit viral replication. Phosphatidyl-inositol 3-kinase (PI3K)/Akt signaling is an important negative regulator of HCMV replication, and during lytic infection the virus utilizes pUL38 to limit Akt phosphorylation and activity. During latency, PI3K/Akt signaling also limits virus replication, but how this is overcome at the time of reactivation is unknown. Virally encoded microRNAs (miRNAs) are a key component of the virus arsenal used to alter signaling during latency and reactivation. In the present study we s

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Soffritti, Irene, Maria D’Accolti, Gloria Ravegnini, et al. "Modulation of microRNome by Human Cytomegalovirus and Human Herpesvirus 6 Infection in Human Dermal Fibroblasts: Possible Significance in the Induction of Fibrosis in Systemic Sclerosis." Cells 10, no. 5 (2021): 1060. http://dx.doi.org/10.3390/cells10051060.

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Human cytomegalovirus (HCMV) and Human herpesvirus 6 (HHV-6) have been reportedly suggested as triggers of the onset and/or progression of systemic sclerosis (SSc), a severe autoimmune disorder characterized by multi-organ fibrosis. The etiology and pathogenesis of SSc are still largely unknown but virological and immunological observations support a role for these beta-herpesviruses, and we recently observed a direct impact of HCMV and HHV-6 infection on the expression of cell factors associated with fibrosis at the cell level. Since miRNA expression has been found profoundly deregulated at t

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Lee, Kyoung Hwa, Seoyeon Min, Seul Gi Yoo, et al. "The Expression of hsp-miRNA-200b-3p and -200c-3p in Human Cytomegalovirus-infected Formalin-Fixed, Paraffin-Embedded Tissues." Open Forum Infectious Diseases 4, suppl_1 (2017): S358. http://dx.doi.org/10.1093/ofid/ofx163.867.

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Abstract Background Human cytomegalovirus (HCMV), which exist as asymptomatic latent status, can cause the tissue invasive disease through reactivation in various immunocompromised conditions. Hsp-microRNA has a specific function of post transcriptional suppression through binding with 3’ untranslated region (UTR) of mRNA. In previous study, hsp-miR-200b-3p and -200c-3p had high probability of conjugation with 3’UTR of mRNA encoded by HCMV UL 122–123 region, which translate the immediate early protein 2 (IE2) protein. IE2 (pp86) plays an essential role to initiate and regulate viral early (E)

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Zhu, Wenbo, and Shuangquan Liu. "The role of human cytomegalovirus in atherosclerosis: a systematic review." Acta Biochimica et Biophysica Sinica 52, no. 4 (2020): 339–53. http://dx.doi.org/10.1093/abbs/gmaa005.

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Abstract Atherosclerosis is a progressive vascular disease with increasing morbidity and mortality year by year in modern society. Human cytomegalovirus (HCMV) infection is closely associated with the development of atherosclerosis. HCMV infection may accelerate graft atherosclerosis and the development of transplant vasculopathy in organ transplantation. However, our current understanding of HCMV-associated atherosclerosis remains limited and is mainly based on clinical observations. The underlying mechanism of the involvement of HCMV infection in atherogenesis remains unclear. Here, we summa

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Pandeya, Abhishek, Raj Kumar Khalko, Anup Mishra, et al. "Human Cytomegalovirus miR-UL70-3p Downregulates the H2O2-Induced Apoptosis by Targeting the Modulator of Apoptosis-1 (MOAP1)." International Journal of Molecular Sciences 23, no. 1 (2021): 18. http://dx.doi.org/10.3390/ijms23010018.

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Human Cytomegalovirus (HCMV) is a prototypic beta herpesvirus, causing persistent infections in humans. There are medications that are used to treat the symptoms; however, there is no cure yet. Thus, understanding the molecular mechanisms of HCMV replication and its persistence may reveal new prevention strategies. HCMV evasive strategies on the antiviral responses of the human host largely rely on its significant portion of genome. Numerous studies have highlighted the importance of miRNA-mediated regulation of apoptosis, which is an innate immune mechanism that eradicates virus-infected cell

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Buck, Amy H., Javier Santoyo-Lopez, Kevin A. Robertson, Diwakar S. Kumar, Martin Reczko, and Peter Ghazal. "Discrete Clusters of Virus-Encoded MicroRNAs Are Associated with Complementary Strands of the Genome and the 7.2-Kilobase Stable Intron in Murine Cytomegalovirus." Journal of Virology 81, no. 24 (2007): 13761–70. http://dx.doi.org/10.1128/jvi.01290-07.

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ABSTRACT The prevalence and importance of microRNAs (miRNAs) in viral infection are increasingly relevant. Eleven miRNAs were previously identified in human cytomegalovirus (HCMV); however, miRNA content in murine CMV (MCMV), which serves as an important in vivo model for CMV infection, has not previously been examined. We have cloned and characterized 17 novel miRNAs that originate from at least 12 precursor miRNAs in MCMV and are not homologous to HCMV miRNAs. In parallel, we applied a computational analysis, using a support vector machine approach, to identify potential precursor miRNAs in

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Wang, Linqian, Ming Yang, Shijing Liao, et al. "Hsa-miR-27b is up-regulated in cytomegalovirus-infected human glioma cells, targets engrailed-2 and inhibits its expression." Experimental Biology and Medicine 242, no. 12 (2017): 1227–33. http://dx.doi.org/10.1177/1535370217699535.

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Human cytomegalovirus (HCMV) dormant infection can alter the expression of the hosts’ microRNAs (miRNAs) and impact on the regulation of target genes. To investigate the differentially expressed miRNAs induced by HCMV in human glioma U251 cells, a comprehensive miRNA screen was performed. As a result, 19 up-regulated and 14 down-regulated miRNAs were determined. Of these, hsa-miR-27b (miR-27b) attracted our attention. MiR-27b levels in U251 cells increased 7.70-fold, 8.64-fold, and 4.78-fold, respectively, post 24 h, 48 h, and 72 h HCMV infection, compared to those in the mimic-infected cells,

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Hong, Yeon-Mi, Seo Yeon Min, Dayeong Kim, et al. "Human MicroRNAs Attenuate the Expression of Immediate Early Proteins and HCMV Replication during Lytic and Latent Infection in Connection with Enhancement of Phosphorylated RelA/p65 (Serine 536) That Binds to MIEP." International Journal of Molecular Sciences 23, no. 5 (2022): 2769. http://dx.doi.org/10.3390/ijms23052769.

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Attenuating the expression of immediate early (IE) proteins is essential for controlling the lytic replication of human cytomegalovirus (HCMV). The human microRNAs (hsa-miRs), miR-200b-3p and miR-200c-3p, have been identified to bind the 3′-untranslated region (3′-UTR) of the mRNA encoding IE proteins. However, whether hsa-miRs can reduce IE72 expression and HCMV viral load or exhibit a crosstalk with the host cellular signaling machinery, most importantly the NF-κB cascade, has not been evaluated. In this study, argonaute-crosslinking and immunoprecipitation-seq revealed that miR-200b-3p and

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Fu, Ya-Ru, Xi-Juan Liu, Xiao-Jun Li, et al. "MicroRNA miR-21 Attenuates Human Cytomegalovirus Replication in Neural Cells by Targeting Cdc25a." Journal of Virology 89, no. 2 (2014): 1070–82. http://dx.doi.org/10.1128/jvi.01740-14.

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ABSTRACTCongenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects, primarily manifesting as neurological disorders. HCMV infection alters expression of cellular microRNAs (miRs) and induces cell cycle arrest, which in turn modifies the cellular environment to favor virus replication. Previous observations found that HCMV infection reduces miR-21 expression in neural progenitor/stem cells (NPCs). Here, we show that infection of NPCs and U-251MG cells represses miR-21 while increasing the levels of Cdc25a, a cell cycle regulator and known target of miR-21. These oppos

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Møller, Rasmus, Toni M. Schwarz, Vanessa M. Noriega, et al. "miRNA-mediated targeting of human cytomegalovirus reveals biological host and viral targets of IE2." Proceedings of the National Academy of Sciences 115, no. 5 (2018): 1069–74. http://dx.doi.org/10.1073/pnas.1719036115.

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Human cytomegalovirus (HCMV) impacts more than one-half of the human population owing to its capacity to manipulate the cell and create latent reservoirs in the host. Despite an extensive understanding of HCMV biology during acute infection in fibroblasts, the molecular basis for latency in myeloid cells remains incomplete. This knowledge gap is due largely to the fact that the existing genetic systems require virus rescue in fibroblasts, precluding the study of genes that are essential during acute infection, yet likely play unique roles in myeloid cells or the establishment of latency. Here

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Carmona-Luque, Maria Dolores, Laura Gonzalez-Alvarez, and José Luis Guerrero Orriach. "Identification of miRNAs as Biomarkers of Cardiac Protection in Non-Genetically Modified Primary Human Cardiomyocytes Exposed to Halogenated Hypnotics in an In Vitro Model of Transfection and Ischemia/Reperfusion: A New Model in Translational Anesthesia." Life 13, no. 1 (2022): 64. http://dx.doi.org/10.3390/life13010064.

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Background: Many clinical studies have identified some circulating micro-RNAs (miRNAs) as potential biomarkers with regard to the cardioprotective effects of halogenated agents administered perioperatively during myocardial conditioning procedures. However, there is a major methodological difficulty in identifying these potential miRNA targets in cardiac cells. Methods: We developed an in vitro protocol to analyze the differential expression of target miRNAs at the intracellular level in non-genetically modified primary human cardiomyocytes (HCMs) through their exposure to different hypnotic c

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Brochado-Kith, Óscar, Alicia Gómez Sanz, Luis Miguel Real, et al. "MicroRNA Profile of HCV Spontaneous Clarified Individuals, Denotes Previous HCV Infection." Journal of Clinical Medicine 8, no. 6 (2019): 849. http://dx.doi.org/10.3390/jcm8060849.

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Factors involved in the spontaneous cleareance of a hepatitis C (HCV) infection are related to both HCV and the interaction with the host immune system, but little is known about the consequences after a spontaneous resolution. The main HCV extrahepatic reservoir is the peripheral blood mononuclear cells (PBMCs), and their transcriptional profile provides us information of innate and adaptive immune responses against an HCV infection. MicroRNAs regulate the innate and adaptive immune responses, and they are actively involved in the HCV cycle. High Throughput sequencing was used to analyze the

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Liu, Yuan, Chaoyun Pan, Donghai Li, Fenyong Liu, and Ke Zen. "Human cytomegalovirus microRNA miR-UL148D facilitates HCMV latency (VIR5P.1024)." Journal of Immunology 192, no. 1_Supplement (2014): 144.7. http://dx.doi.org/10.4049/jimmunol.192.supp.144.7.

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Abstract Human cytomegalovirus (HCMV), infects a majority of population and can undergo life-long, latent infection, is a leading cause of opportunistic and congenital disease. HCMV can encode 17 microRNAs (miRNAs) but the roles of these viral miRNAs during viral infection are unclear. Here, we infected human bone marrow and CD34+ hematopoietic progenitor Kasumi-3 cells with HCMV (strain NR-1) and determined the kinetics of cellular levels of all hcmv miRNAs by qRT-PCR. We found that, different from most other hcmv miRNAs which had high level at early days of infection, hcmv-miR-UL148D was hig

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Guerrero-Orriach, José Luis, Maria Dolores Carmona-Luque, Guillermo Quesada Muñoz, and Maria Jose Rodriguez Capitán. "miRNA Expression: I/R Cardiomyocyte and Sevoflurane." Biomolecules 14, no. 12 (2024): 1554. https://doi.org/10.3390/biom14121554.

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Background: The effects of anesthetic drugs on myocardial cells have been a subject of research for the last 50 years. The clinical benefits of halogenated agents, particularly sevoflurane, have been demonstrated in cardiac surgery patients. These benefits are due to the action of different enzymes and a variety of molecular pathways mediated by the action of small noncoding RNAs (sRNA) such as microRNAs (miRNAs). However, the modulation potential induced by anesthetic drugs on the miRNA expression and their cardioprotective effects is unknown. Objective: To analyze the variation in the expres

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Diggins, Nicole L., Rebecca L. Skalsky, and Meaghan H. Hancock. "Regulation of Latency and Reactivation by Human Cytomegalovirus miRNAs." Pathogens 10, no. 2 (2021): 200. http://dx.doi.org/10.3390/pathogens10020200.

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Human cytomegalovirus (HCMV) encodes 22 mature microRNAs (miRNAs), which regulate a myriad of cellular processes, including vesicular trafficking, cell cycle progression, apoptosis, and immune evasion, as well as viral gene expression. Recent evidence points to a critical role for HCMV miRNAs in mediating latency in CD34+ hematopoietic progenitor cells through modulation of cellular signaling pathways, including attenuation of TGFβ and EGFR signaling. Moreover, HCMV miRNAs can act in concert with, or in opposition to, viral proteins in regulating host cell functions. Here, we comprehensively r

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Guerrero-Orriach, Jose Luis, Maria Dolores Carmona-Luque, Maria Jose Rodriguez-Capitan, and Guillermo Quesada-Muñoz. "MicroRNA-197-3p Transfection: Variations in Cardiomyocyte Gene Expression with Anaesthetics Drugs in a Model of Hypoxia/Reperfusion." Pharmaceuticals 18, no. 2 (2025): 146. https://doi.org/10.3390/ph18020146.

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Background: Our research team analyzed the microRNA (miRNA)-197-3p involved in cardioprotection, and we demonstrated that the overexpression of miRNA-197-3p could be linked to a higher risk of cardiac damage. Recent research indicated that miRNA-197-3p inhibits the effector proteins of the anaesthetic preconditioning mechanism of halogenated drugs. In this scenario, we proposed to determine the role of miRNA-197-3p in cardiac injury and its effects on myocardial conditioning under halogenated exposure. Hypothesis: Patients having myocardial revascularization surgery have increased heart damage

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Dalla, Emiliano, Michela Bulfoni, Daniela Cesselli, et al. "Reinfection of Transplanted Livers in HCV- and HCV/HIV-Infected Patients Is Characterized by a Different MicroRNA Expression Profile." Cells 11, no. 4 (2022): 690. http://dx.doi.org/10.3390/cells11040690.

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Background: After liver transplantation, HCV/HIV co-infected patients present, compared to the HCV mono-infected ones, increased HCV viral load, rapid progression to liver fibrosis and higher mortality. Liver biopsies (LB), obtained routinely 6 months after transplantation, represent a unique model to assess the early events related to graft re-infection. Here, we used miRNA sequencing of LB obtained from both HCV-and HCV/HIV-infected recipients, to identify transcriptional profiles able to explain the more severe outcome of these latter. Methods: miRNAs of 3 healthy livers, 3 HCV-LB and 3 HCV

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Valle-Millares, Daniel, Óscar Brochado-Kith, Luz Martín-Carbonero, et al. "Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients." Biomedicines 9, no. 11 (2021): 1627. http://dx.doi.org/10.3390/biomedicines9111627.

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Micro RNAs (miRNAs) are essential players in HIV and HCV infections, as both viruses modulate cellular miRNAs and interact with the miRNA-mediated host response. We aim to analyze the miRNA profile of HIV patients with different exposure to HCV to explore specific signatures in the miRNA profile of PBMCs for each type of infection. We massively sequenced small RNAs of PBMCs from 117 HIV+ infected patients: 45 HIV+ patients chronically infected with HCV (HIV/HCV+), 36 HIV+ that spontaneously clarified HCV after acute infection (HIV/HCV-) and 36 HIV+ patients without previous HCV infection (HIV)

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Manzoor, Sadia, Imran Riaz Malik, Shah Jahan, et al. "Serum MicroRNAs as Predictors for HCV Progression and Response to Treatment in Pakistani Patients." Genes 14, no. 2 (2023): 441. http://dx.doi.org/10.3390/genes14020441.

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Hepatitis is one of the common liver diseases, imposing a heavy health burden worldwide. Acute hepatitis may develop into chronic hepatitis, progressing to cirrhosis and hepatocellular carcinoma. In the present study, the expression of miRNAs was quantified by real-time PCR, such as miRNA-182, 122, 21, 150, 199, and 222. Along with the control group, HCV was divided into chronic, cirrhosis, and HCC groups. The treated group was also included after the successful treatment of HCV. Biochemical parameters, such as ALT, AST, ALP, bilirubin, viral load, and AFP (HCC), were also evaluated in all of

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Zeng, Janine, Di Cao, Shaomin Yang, et al. "Insights into the Transcriptome of Human Cytomegalovirus: A Comprehensive Review." Viruses 15, no. 8 (2023): 1703. http://dx.doi.org/10.3390/v15081703.

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Human cytomegalovirus (HCMV) is a widespread pathogen that poses significant risks to immunocompromised individuals. Its genome spans over 230 kbp and potentially encodes over 200 open-reading frames. The HCMV transcriptome consists of various types of RNAs, including messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs), with emerging insights into their biological functions. HCMV mRNAs are involved in crucial viral processes, such as viral replication, transcription, and translation regulation, as well as immune modulation and other effects

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Khikani, Ali Nadhim, Müge Firat, and Zaytoon Abdulrida Al-Khafaji. "Association of hcmv-miR-UL36-5P Gene Expression with Miscarriages in Women with Human Cytomegalovirus Infection in Babylon, Iraq." Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ) 7, no. 2 (2024): 43–48. http://dx.doi.org/10.54133/ajms.v7i2.1363.

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Background: HCMV is a prevalent virus that affects a significant section of the human population, causes severe disease, and affects the fetus in pregnant women. hcmv-miRNAs are important regulatory molecules in miscarriages in women CMV-infected. Objective: To evaluate the association of hcmv-miR-UL36-5P gene expression with miscarriages in women with HCMV. Methods: A case-control study was designed to include 140 women who had miscarriages at random, and 50 of them who had miscarriages with a high CMV viral load were categorized as miscarriage groups. Additionally, 50 healthy pregnant women

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Pham, Andrew H., Jennifer Mitchell, Sara Botto, Kara M. Pryke, Victor R. DeFilippis та Meaghan H. Hancock. "Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons". PLOS Pathogens 17, № 8 (2021): e1009380. http://dx.doi.org/10.1371/journal.ppat.1009380.

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Human cytomegalovirus (HCMV) microRNAs (miRNAs) significantly rewire host signaling pathways to support the viral lifecycle and regulate host cell responses. Here we show that SMAD3 expression is regulated by HCMV miR-UL22A and contributes to the IRF7-mediated induction of type I IFNs and IFN-stimulated genes (ISGs) in human fibroblasts. Addition of exogenous TGFβ interferes with the replication of a miR-UL22A mutant virus in a SMAD3-dependent manner in wild type fibroblasts, but not in cells lacking IRF7, indicating that downregulation of SMAD3 expression to limit IFN induction is important f

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Augello, Claudia, Umberto Gianelli, Federica Savi, et al. "MicroRNA as potential biomarker in HCV-associated diffuse large B-cell lymphoma." Journal of Clinical Pathology 67, no. 8 (2014): 697–701. http://dx.doi.org/10.1136/jclinpath-2014-202352.

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AimsTo identify molecular characteristics to hepatitis C virus (HCV)-associated diffuse large B-cell lymphoma (DLBCL) through a comprehensive miRNAs expression profiling.MethodsIn this study, miRNA profiles were obtained from 37 patients with DLBCLs and 60 patients with reactive lymph nodes, equally distributed according to HCV presence. Germinal centres, from reactive lymph nodes were used as controls. Clinical features at presentation were available for all patients.ResultsA set of 52 miRNAs define a signature for HCV-associated DLBCL. Importantly, decreased expression of miR-138-5p and incr

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Dabbish, Areeg M., Hana M. Abdelzaher, Moustafa Abohawya, et al. "Prognostic MicroRNA Panel for HCV-Associated HCC: Integrating Computational Biology and Clinical Validation." Cancers 14, no. 13 (2022): 3036. http://dx.doi.org/10.3390/cancers14133036.

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Early detection of hepatocellular carcinoma (HCC) will reduce morbidity and mortality rates of this widely spread disease. Dysregulation in microRNA (miRNA) expression is associated with HCC progression. The objective is to identify a panel of differentially expressed miRNAs (DE-miRNAs) to enhance HCC early prediction in hepatitis C virus (HCV) infected patients. Candidate miRNAs were selected using a bioinformatic analysis of microarray and RNA-sequencing datasets, resulting in nine DE-miRNAs (miR-142, miR-150, miR-183, miR-199a, miR-215, miR-217, miR-224, miR-424, and miR-3607). Their expres

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Joshi, Nicky, Madhuri Chandane Tak, and Anupam Mukherjee. "The involvement of microRNAs in HCV and HIV infection." Therapeutic Advances in Vaccines and Immunotherapy 10 (January 2022): 251513552211061. http://dx.doi.org/10.1177/25151355221106104.

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Approximately 2.3 million people are suffering from human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infection worldwide. Faster disease progression and increased mortality rates during the HIV/HCV co-infection have become global health concerns. Effective therapeutics against co-infection and complete infection eradication has become a mandatory requirement. The study of small non-coding RNAs in cellular processes and viral infection has so far been beneficial in various terms. Currently, microRNAs are an influential candidate for disease diagnosis and treatment. Dysregulation in

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Pascut, Devis, Minh Hoang, Nhu N. Q. Nguyen, Muhammad Yogi Pratama, and Claudio Tiribelli. "HCV Proteins Modulate the Host Cell miRNA Expression Contributing to Hepatitis C Pathogenesis and Hepatocellular Carcinoma Development." Cancers 13, no. 10 (2021): 2485. http://dx.doi.org/10.3390/cancers13102485.

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Hepatitis C virus (HCV) genome encodes for one long polyprotein that is processed by cellular and viral proteases to generate 10 polypeptides. The viral structural proteins include the core protein, and the envelope glycoproteins E1 and E2, present at the surface of HCV particles. Non-structural (NS) proteins consist of NS1, NS2, NS3, NS4A, NS4B, NS5a, and NS5b and have a variable function in HCV RNA replication and particle assembly. Recent findings evidenced the capacity of HCV virus to modulate host cell factors to create a favorable environment for replication. Indeed, increasing evidence

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Romano, Antonietta, Alessandra Brocca, Zoe Mariño, et al. "miRNA Expression and HCC Occurrence in HCV Cirrhotic Patients Treated with Direct Acting Antivirals." Livers 4, no. 2 (2024): 275–86. http://dx.doi.org/10.3390/livers4020020.

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Background: The risk of hepatocarcinoma in HCV cirrhotic patient responders after treatment with DAAs decrease, but HCC still occurs. A correlation between specific miRNAs and the development of hepatocarcinoma have been highlighted. Aim: To investigate miRNA expression in HCV-infected cirrhotic patients treated with DAAs, regarding whether or not they developed HCC at follow-up. Methods: A total of 73 outpatients with HCV-related cirrhosis treated with DAAs were enrolled, 28 of which had HCC. Samples were collected at the start and at the end of treatment. In the screening phase, 172 miRNAs w

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Nappi, Francesco, Almothana Alzamil, Sanjeet Singh Avtaar Singh, Cristiano Spadaccio, and Nicolas Bonnet. "Current Knowledge on the Interaction of Human Cytomegalovirus Infection, Encoded miRNAs, and Acute Aortic Syndrome." Viruses 15, no. 10 (2023): 2027. http://dx.doi.org/10.3390/v15102027.

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Aortic dissection is a clinicopathological entity caused by rupture of the intima, leading to a high mortality if not treated. Over time, diagnostic and investigative methods, antihypertensive therapy, and early referrals have resulted in improved outcomes according to registry data. Some data have also emerged from recent studies suggesting a link between Human Cytomegalovirus (HCMV) infection and aortic dissection. Furthermore, the use of microRNAs has also become increasingly widespread in the literature. These have been noted to play a role in aortic dissections with elevated levels noted

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Lin, Tsun-Mei, and Hock-Liew Eng. "Functional elucidation of miR-494 in modulation of HCV infection." Journal of Immunology 202, no. 1_Supplement (2019): 127.5. http://dx.doi.org/10.4049/jimmunol.202.supp.127.5.

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Abstract Hepatitis C virus (HCV) infection is considered one of the most important causes of chronic liver diseases due to major alteration in the cross-talk between hepatic cells and immune cells. Many reports have shown that the proteins of HCV might interact with the genes to regulate cellular pathways and miRNA expression contribute to the pathogenesis of liver diseases. In this study, the profiling of miRNAs in hepatocytes transfected with HCV structure proteins was compared by microarray analysis. MiR-494 was significantly decreased in E1 transfected HepG2 cells, but increase in core-tra

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Fan, Jianmin, Wen Zhang, and Qiming Liu. "Human Cytomegalovirus-Encoded miR-US25-1 Aggravates the Oxidised Low Density Lipoprotein-Induced Apoptosis of Endothelial Cells." BioMed Research International 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/531979.

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Human cytomegalovirus (HCMV) infection is linked to the development and severity of the cardiovascular disease atherosclerosis; however, there is little known about the promotion of atherosclerosis. miR-US25-1 is one of HCMV-encoded miRNAs and targets cellular genes that are essential for virus growth to control the life cycle of the virus and host cells. The prominent regulation on cell cycle genes of the miR-US25-1 attracts us to explore its role in the atherosclerosis promotion. It was indicated that miR-US25-1 level was upregulated in subjects or in endothelial cells with HCMV infection; a

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Gholizadeh, Maryam, Joanna Łapczuk-Romańska, Mariola Post, et al. "A Mixture Method for Robust Detection HCV Early Diagnosis Biomarker with ML Approach and Molecular Docking." International Journal of Molecular Sciences 24, no. 8 (2023): 7207. http://dx.doi.org/10.3390/ijms24087207.

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Given the substantial correlation between early diagnosis and prolonged patient survival in HCV patients, it is vital to identify a reliable and accessible biomarker. The purpose of this research was to identify accurate miRNA biomarkers to aid in the early diagnosis of HCV and to identify key target genes for anti-hepatic fibrosis therapeutics. The expression of 188 miRNAs in 42 HCV liver patients with different functional states and 23 normal livers were determined using RT-qPCR. After screening out differentially expressed miRNA (DEmiRNAs), the target genes were predicted. To validate targe

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Gupta, P., B. Liu, J. Q. Wu, et al. "Genome-wide mRNA and miRNA analysis of peripheral blood mononuclear cells (PBMC) reveals different miRNAs regulating HIV/HCV co-infection." Virology 450-451 (February 2014): 336–49. http://dx.doi.org/10.1016/j.virol.2013.12.026.

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Damjanovska, Sofi, Hawwa Alao, Elizabeth Zebrowski, et al. "During HCV DAA Therapy Plasma Mip1B, IP10, and miRNA Profile Are Distinctly Associated with Subsequent Diagnosis of Hepatocellular Carcinoma: A Pilot Study." Biology 11, no. 9 (2022): 1262. http://dx.doi.org/10.3390/biology11091262.

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Background: Hepatitis C virus (HCV) therapy lowers risk of hepatocellular carcinoma (HCC). Little is known about factors driving/preceding HCC in treated persons. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) regulate host response and pathogenesis of disease. We investigated plasma levels of these RNAs and select serum markers before, during, and after HCV therapy, preceding HCC. Methods: Of 187 DAA treated HCV patients where therapy oriented longitudinal sampling was performed at a time without HCC diagnosis, 9 were subsequently diagnosed with HCC within 2 years of therapy. They were

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Yang, Xiao, Katherine Marcucci, Xavier Anguela, and Linda B. Couto. "Preclinical Evaluation of An Anti-HCV miRNA Cluster for Treatment of HCV Infection." Molecular Therapy 21, no. 3 (2013): 588–601. http://dx.doi.org/10.1038/mt.2012.247.

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Abdel-Al, Amanda, Eman El-Ahwany, Mona Zoheiry, et al. "miRNA-221 and miRNA-222 are promising biomarkers for progression of liver fibrosis in HCV Egyptian patients." Virus Research 253 (July 2018): 135–39. http://dx.doi.org/10.1016/j.virusres.2018.06.007.

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Zhuang, Haiming, Dong Ji, Jigang Fan, et al. "Mechanistic Insights into the Protection Effect of Argonaute–RNA Complex on the HCV Genome." Biomolecules 12, no. 11 (2022): 1631. http://dx.doi.org/10.3390/biom12111631.

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While host miRNA usually plays an antiviral role, the relentless tides of viral evolution have carved out a mechanism to recruit host miRNA as a viral protector. By complementing miR-122 at the 5′ end of the genome, the hepatitis C virus (HCV) gene can form a complex with Argonaute 2 (Ago2) protein to protect the 5′ end of HCV RNA from exonucleolytic attacks. Experiments showed that the disruption of the stem-loop 1(SL1) structure and the 9th nucleotide (T9) of HCV site 1 RNA could enhance the affinity of the Ago2 protein to the HCV site 1 RNA (target RNA). However, the underlying mechanism of

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Yameny, Ahmed. "miRNA-122 from Laboratory biomarker to the treatment of HCV." Journal of Bioscience and Applied Research 3, no. 4 (2017): 145–51. http://dx.doi.org/10.21608/jbaar.2017.125861.

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Shang, Zhenlin, Sitong Liu, Dongxu Liu, et al. "CRISPR/Cas12a with Universal crRNA for Indiscriminate Virus Detection." Molecules 29, no. 24 (2024): 6066. https://doi.org/10.3390/molecules29246066.

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Viruses, known for causing widespread biological harm and even extinction, pose significant challenges to public health. Virus detection is crucial for accurate disease diagnosis and preventing the spread of infections. Recently, the outstanding analytical performance of CRISPR/Cas biosensors has shown great potential and they have been considered as augmenting methods for reverse-transcription polymerase chain reaction (RT-PCR), which was the gold standard for nucleic acid detection. We herein utilized Cas12a with universal CRISPR RNA (crRNA) for indiscriminate virus detection by attaching th

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Wu, Zhenhua, Yunpeng Bai, Yujuan Qi, et al. "lncRNA NEAT1 Downregulation Ameliorates the Myocardial Infarction of Mice by Regulating the miR-582-5p/F2RL2 Axis." Cardiovascular Therapeutics 2022 (December 3, 2022): 1–14. http://dx.doi.org/10.1155/2022/4481360.

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Background. This study is aimed at effectively investigating the role of coagulation factor II thrombin receptor like 2 (F2RL2) in myocardial infarction (MI) as well as the upstream regulatory miRNA and lncRNA. Methods. Regulatory genes of F2RL2 were analyzed using StarBase and verified by dual-luciferase reporter assay. The MI mouse model was established. The left ventricular ejection fraction (EF) and fractional shortening (FS) were examined by echocardiography. The infarct area, pathological changes, and cell apoptosis in mouse myocardial tissue were evaluated using triphenyltetrazolium chl

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