Academic literature on the topic 'MiRNA microarray'

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Journal articles on the topic "MiRNA microarray"

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Nersisyan, Stepan, Maxim Shkurnikov, Andrey Poloznikov, et al. "A Post-Processing Algorithm for miRNA Microarray Data." International Journal of Molecular Sciences 21, no. 4 (2020): 1228. http://dx.doi.org/10.3390/ijms21041228.

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One of the main disadvantages of using DNA microarrays for miRNA expression profiling is the inability of adequate comparison of expression values across different miRNAs. This leads to a large amount of miRNAs with high scores which are actually not expressed in examined samples, i.e., false positives. We propose a post-processing algorithm which performs scoring of miRNAs in the results of microarray analysis based on expression values, time of discovery of miRNA, and correlation level between the expressions of miRNA and corresponding pre-miRNA in considered samples. The algorithm was succe
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Palmieri, Annalisa, Furio Pezzetti, Anna Avantaggiato, et al. "Titanium Acts on Osteoblast Translational Process." Journal of Oral Implantology 34, no. 4 (2008): 190–94. http://dx.doi.org/10.1563/0.869.1.

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Abstract Titanium is a highly biocompatible material and very osteogenic in vivo. However, how titanium regulates osteoblast activity to promote bone formation is incompletely characterized. We, therefore, attempted to get more information by using microRNA (miRNA) microarray techniques to investigate translation regulation in osteoblasts grown on titanium disks. The miRNA oligonucleotide microarray provides a novel method to carry out genome-wide miRNA profiling in human samples. By using miRNA microarrays containing 329 probes designed from the human miRNA sequence, several miRNA were identi
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Shaoqing, Yu, Zhang Ruxin, Liu Guojun, et al. "Microarray Analysis of Differentially Expressed microRNAs in Allergic Rhinitis." American Journal of Rhinology & Allergy 25, no. 6 (2011): e242-e246. http://dx.doi.org/10.2500/ajra.2011.25.3682.

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Background Allergic rhinitis (AR) is a common disease characterized by chronic inflammation of the nasal mucosa, but we have not fully understood the mechanism responsible for the development of AR. MicroRNAs (miRNAs) are short endogenous noncoding RNAs regulating protein translation through a mechanism known as RNA interference. To understand the molecular mechanisms of miRNA involved in the pathogenesis of AR, expressed miRNAs in AR were investigated through genomewide microarray analysis. Methods Mammalian miRNA microarrays containing whole human mature and precursor miRNA sequences were us
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Boštjančič, Emanuela, Nina Zidar, and Damjan Glavač. "MicroRNA Microarray Expression Profiling in Human Myocardial Infarction." Disease Markers 27, no. 6 (2009): 255–68. http://dx.doi.org/10.1155/2009/641082.

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MicroRNAs (miRNAs), small non-coding RNA molecules, are negative regulators of gene expression. Recent studies have indicated their role in various forms of cardiovascular disease. In spite of the number of miRNA microarray analyses performed, little is known about the genome-wide miRNA expression pattern in human myocardial infarction (MI). Using miRNA microarrays and bioinformatic analysis, miRNA expression was analyzed on human MI and foetal hearts compared to healthy adult hearts, to determine whether there is any similar expression pattern between MI and foetal hearts, and to identified m
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Yan, Naihong, Yilu Lu, Huaqin Sun, et al. "A microarray for microRNA profiling in mouse testis tissues." Reproduction 134, no. 1 (2007): 73–79. http://dx.doi.org/10.1530/rep-07-0056.

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MicroRNAs (miRNAs) are short non-coding RNA molecules playing regulatory roles by repressing translation or cleaving RNA transcripts. Recent studies indicate that miRNAs are mechanistically involved in the development of mammalian spermatogenesis. However, little work has been done to compare the miRNA expression patterns between immature and mature mouse testes. Here, we employed a miRNA microarray to detect 892 miRNAs in order to evaluate the expression patterns of miRNA. The expression of 19 miRNAs was significantly different between immature and mature individuals. Fourteen miRNAs were sig
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Wang, Shu-Ting, Cai Li, and Lei Liu. "miRNA Microarray Technology in miRNA Profiling." Current Bioinformatics 4, no. 2 (2009): 141–48. http://dx.doi.org/10.2174/157489309788184783.

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Huang, Xin, Chang Liu, Cuifang Hao, et al. "Identification of altered microRNAs and mRNAs in the cumulus cells of PCOS patients: miRNA-509-3p promotes oestradiol secretion by targeting MAP3K8." Reproduction 151, no. 6 (2016): 643–55. http://dx.doi.org/10.1530/rep-16-0071.

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Abstract Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women and is characterised by polycystic ovaries, hyperandrogenism and chronic anovulation. Although the clinical and biochemical signs of PCOS are typically heterogeneous, abnormal folliculogenesis is considered a common characteristic of PCOS. Our aim is to identify the altered miRNA and mRNA expression profiles in the cumulus cells of PCOS patients to investigate their molecular function in the aetiology and pathophysiology of PCOS. In this study, the miRNA expression profiles of the cumulus cell sampl
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Zhang, Yaping, Nan Ding, Hanlu Yi, et al. "Identification of differentially expressed miRNA 48 h after cerebral ischemia–reperfusion injury in mice by the technique of miRNA microarray." Canadian Journal of Physiology and Pharmacology 98, no. 12 (2020): 855–60. http://dx.doi.org/10.1139/cjpp-2019-0701.

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The objective was to identify the differential expressed miRNA during cerebral ischemia–reperfusion injury (CIRI) process, thereby assisting in elucidating the mechanism of CIRI development and providing a potential target for CIRI prevention and treatment. Six mice were randomly assigned to two groups: control group and CIRI model group. A global cerebral IR model by four-vessel occlusion was prepared among the CIRI model group. Brain tissues were collected 48 h after reperfusion. Total RNA was extracted for each sample. miRNA microarrays were employed to detect the differentially expressed m
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Vartanian, Keri B., Hugh D. Mitchell, Susan L. Stevens, Valerie K. Conrad, Jason E. McDermott, and Mary P. Stenzel-Poore. "CpG Preconditioning Regulates Mirna Expression That Modulates Genomic Reprogramming Associated with Neuroprotection against Ischemic Injury." Journal of Cerebral Blood Flow & Metabolism 35, no. 2 (2014): 257–66. http://dx.doi.org/10.1038/jcbfm.2014.193.

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Cytosine-phosphate-guanine (CpG) preconditioning reprograms the genomic response to stroke to protect the brain against ischemic injury. The mechanisms underlying genomic reprogramming are incompletely understood. MicroRNAs (miRNAs) regulate gene expression; however, their role in modulating gene responses produced by CpG preconditioning is unknown. We evaluated brain miRNA expression in response to CpG preconditioning before and after stroke using microarray. Importantly, we have data from previous gene microarrays under the same conditions, which allowed integration of miRNA and gene express
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Weishaupt, Sonja U., Steffen Rupp, and Karin Lemuth. "Simultaneous Detection of Different MicroRNA Types Using the ZIP-Code Array System." Journal of Nucleic Acids 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/496425.

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MicroRNAs (miRNAs) are important negative regulators of gene expression. Their implication in tumorigenesis is based on their dysregulation in many human cancer diseases. Interestingly, in tumor cells, an altered ratio of precursor and mature miRNA levels has been described. Consequently, differences in miRNA type levels have a high potential as biomarkers and comparative high-throughput-based detection might permit a more accurate characterization of subtypes, especially in the case of very heterogeneous tumor entities. Several molecular methods exist for the detection of mature and precursor
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Dissertations / Theses on the topic "MiRNA microarray"

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Semeghini, Mayara Sgarbi. "Avaliação da expressão gênica em larga escala de células osteoblásticas da calvária e da medula óssea de ratas ovariectomizadas." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/58/58137/tde-20032015-083227/.

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A remodelação óssea é um processo fisiológico que mantém a integridade do esqueleto através da substituição do osso antigo por uma matriz óssea jovem. No entanto, na osteoporose a formação óssea, comparada à reabsorção, fica prejudicada em virtude da queda do número de osteoblastos e redução de suas atividades, levando a uma perda da microarquitetura do tecido ósseo, tornando-o frágil e com suscetibilidade à fratura. O objetivo deste trabalho foi comprovar diferenças comportamentais em células osteoblásticas provenientes da medula óssea e da calvária de ratas induzidas à osteoporose por meio d
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Stokowy, Tomasz, Markus Eszlinger, Michał Świerniak, et al. "Analysis options for high-throughput sequencing in miRNA expression profiling." Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-144393.

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Background: Recently high-throughput sequencing (HTS) using next generation sequencing techniques became useful in digital gene expression profiling. Our study introduces analysis options for HTS data based on mapping to miRBase or counting and grouping of identical sequence reads. Those approaches allow a hypothesis free detection of miRNA differential expression. Methods: We compare our results to microarray and qPCR data from one set of RNA samples. We use Illumina platforms for microarray analysis and miRNA sequencing of 20 samples from benign follicular thyroid adenoma and malignant folli
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Matilda, Rentoft. "The use of formalin fixed paraffin embedded tissue and global gene expression profiling for increased understanding of squamous cell carcinoma of the tongue." Doctoral thesis, Umeå universitet, Patologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54005.

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Head and neck cancer is the 6th most common malignancy worldwide, with tumours of the tongue being one of the most prevalent sites. Despite advances in surgery and radiotherapy, the five-year survival has not changed during the last decades and remains at approximately 50%. Identification of novel biomarkers for more personalized treatment is important for increasing survival in these patients. One of the most commonly used methods in the search for new biomarkers is microarray analysis. A substantial limitation with this technique is the requirement for fresh frozen samples from which high qu
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Yabuta, Paula Barbim Donate. "O papel dos microRNAs de células T na susceptibilidade/resistência a artrite reumatóide experimental." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-16022012-150623/.

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Os microRNAs são pequenos RNAs, não-codificantes que funcionam como reguladores a nível pós-transcricional da expressão gênica. Nos últimos anos, novas evidências demonstram o papel importante dos microRNAs na regulação e desenvolvimento do sistema imune. Apesar da função de poucos microRNAs ser conhecida, a sua expressão alterada vêm sendo associada a patogênese de diversas doenças autoimunes, incluindo a artrite reumatóide (AR). Recentemente a expressão desregulada de uma série de microRNAs está sendo descrita em pacientes com AR, e o papel patogênico de apenas uma parte deles foi investigad
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Timoszczuk, Luciana Maria Sevo. "Análise de proteínas cuja expressão é controlada por miRNA e relacionada à progressão do adenocarcinoma de próstata por imuno-histoquimica em tissue microarray." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-13122012-162235/.

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Introdução: O Câncer de Próstata (CaP) é o tumor mais comum do homem e a segunda causa de óbito por câncer no Brasil. MicroRNA (miRNA) é uma classe de pequenos RNA regulatórios não codificantes de proteínas que tem papel fundamental no controle da expressão dos genes. São responsáveis pelo controle de processos fundamentais na célula e estão envolvidos na tumorigênese em humanos. Previamente demonstramos alterações no perfil de expressão dos miRNA 100, let7c e 218 comparando carcinomas localizados e metastáticos. A caracterização de perfis de expressão de suas proteínas alvo no CaP é crucial p
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Dagdas, Yasin Fatih. "Investigating The Roles Of Micrornas In Biotic Stress Responses And Functional Characterization Of A Novel Ztl-type F-box Protein Via Virus Induced Gene Silencing." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/12610641/index.pdf.

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Barley and wheat are the two most important crop species in Turkey. Molecular studies for increasing crop yield of these species are very important for the economic benefits of Turkey. Powdery mildew and yellow rust are the two main pathogens, infecting barley and wheat, respectively in our country and causing a great amount of yield loss each year. Till now, classical genetics studies were performed in order to develop resistant barley and wheat cultivars, but these studies have not been succesful. Therefore, molecular plant-pathogen interactions studies are starting to become the new tool to
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Junge, Christoph Günter [Verfasser], Andrea [Gutachter] Tannapfel, and Raphael [Gutachter] Stoll. "Transkriptom- und Interaktomanalyse von miR-148a mittels mRNA-Microarray nach Biotin-miRNA-Pull-Down im duktalen Adenokarzinom des Pankreas / Christoph Günter Junge. Gutachter: Andrea Tannapfel ; Raphael Stoll." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/1102525154/34.

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Guidi, Mònica. "Micro RNA-Mediated regulation of the full-length and truncated isoforms of human neurotrophic tyrosine kinase receptor type 3 (NTRK 3)." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7114.

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Neurotrophins and their receptors are key molecules in the development of the<br/>nervous system. Neurotrophin-3 binds preferentially to its high-affinity receptor<br/>NTRK3, which exists in two major isoforms in humans, the full-length kinaseactive<br/>form (150 kDa) and a truncated non-catalytic form (50 kDa). The two<br/>variants show different 3'UTR regions, indicating that they might be differentially<br/>regulated at the post-transcriptional level. In this work we explore how<br/>microRNAs take part in the regulation of full-length and truncated NTRK3,<br/>demonstrating that the two isof
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Pignata, Luiz Fernando Martins. "Pipeline para Análise In Sílico de Dados de Expressão de miRNAs e mRNAs em Células de Mamíferos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-14062012-132754/.

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Os microRNAs estão envolvidos no processo de regulação da expressão gênica da célula, onde a molécula de microRNA se liga com o RNA mensageiro interrompendo, assim, a expressão do respectivo gene pela interrupção da tradução. A bioinformática tem auxiliado na identificação de vários genes codificadores de microRNAs em plantas e animais, incluindo mamíferos, por meio de analises de dados de microarray; assim como na predição de estruturas. Os dados de expressão de microRNAs e RNAs mensageiros foram obtidos por meio de cooperação firmada entre o Laboratório de Bioinformática do Departamento de G
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Lueong, Smiths Sengkwawoh [Verfasser], and Christine E. [Akademischer Betreuer] Clayton. "Trypanosoma brucei: Protein Expression Microarrays and Circulating miRNA during Infection / Smiths Sengkwawoh Lueong ; Betreuer: Christine E. Clayton." Heidelberg : Universitätsbibliothek Heidelberg, 2014. http://d-nb.info/1180300149/34.

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Book chapters on the topic "MiRNA microarray"

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Wang, Zhiguo, and Baofeng Yang. "Microarray and Its Variants for miRNA Profiling." In MicroRNA Expression Detection Methods. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-04928-6_2.

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Yeung, Man Lung, and Kuan-Teh Jeang. "Microarray Profiling of microRNA Changes in Cells That Express HIV-1 Proteins." In Current Perspectives in microRNAs (miRNA). Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-8533-8_21.

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Bassani, Niccolò, Federico Ambrogi, Cristina Battaglia, and Elia Biganzoli. "Reliability of miRNA Microarray Platforms: An Approach Based on Random Effects Linear Models." In Computational Intelligence Methods for Bioinformatics and Biostatistics. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-35686-5_6.

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Zhou, Yiqian, Rehman Qureshi, and Ahmet Sacan. "Analysis of Paired miRNA-mRNA Microarray Expression Data Using a Stepwise Multiple Linear Regression Model." In Bioinformatics Research and Applications. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-59575-7_6.

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Novosel, Astrid, and Arndt Borkhardt. "miRNA patterns in hematopoietic malignancies." In Microarrays in Inflammation. Birkhäuser Basel, 2008. http://dx.doi.org/10.1007/978-3-7643-8334-3_14.

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Ichikawa, Makiko, and Hideo Akiyama. "A Combination of Extraction Reagent and DNA Microarray That Allows for the Detection of Global MiRNA Profiles from Serum/Plasma." In Methods in Molecular Biology. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-453-1_20.

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Saba, Reuben, and Stephanie A. Booth. "MicroRNA Profiling in CNS Tissue Using Microarrays." In Current Perspectives in microRNAs (miRNA). Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-8533-8_5.

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Wu, Di, and Michael P. Gantier. "Normalization of Affymetrix miRNA Microarrays for the Analysis of Cancer Samples." In Methods in Molecular Biology. Springer New York, 2015. http://dx.doi.org/10.1007/7651_2015_239.

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White, Peter. "Profiling the miRNome: Detecting Global miRNA Expression Levels with DNA Microarrays." In Neuromethods. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-114-7_6.

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Zhang, Junling, Shanshan Zhao, and Jikui Wu. "Novel Biosensing Strategies for the in Vivo Detection of microRNA." In Biosensor - Current and Novel Strategies for Biosensing [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.93937.

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As a regulatory molecule of post-transcriptional gene expression, microRNA (miRNA) is a class of endogenous, non-coding small molecule RNAs. MiRNA detection is essential for biochemical research and clinical diagnostics but challenging due to its low abundance, small size, and sequence similarities. In this chapter, traditional methods of detecting miRNA like polymerase chain reaction (PCR), DNA microarray, and northern blotting are introduced briefly. These approaches are usually used to detect miRNA in vitro. Some novel strategies for sensing miRNAs in vivo, including hybridization probe assays, strand-displacement reaction (SDR), entropy-driven DNA catalysis (EDC), catalytic hairpin assembly (CHA), hybridization chain reaction (HCR), DNAzyme-mediated assays, and CRISPR-mediated assays, are elaborated in detail. This chapter describes the principles and designs of these detection technologies and discusses their advantages as well as their shortcomings, providing guidelines for the further development of more sensitive and selective miRNA sensing strategies in vivo.
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Conference papers on the topic "MiRNA microarray"

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Dymacek, Julian, and Nancy Lan Guo. "Integrated miRNA and mRNA analysis of time series microarray data." In BCB '14: ACM-BCB '14. ACM, 2014. http://dx.doi.org/10.1145/2649387.2649411.

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Kikuchi, Hirotoshi, Ichirota Iino, Shinichiro Miyazaki, et al. "Abstract 4008: cDNA and miRNA microarray analysis comparing gastric and metastatic liver gastrointestinal stromal tumors." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4008.

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Sudo, Hiroko, Yoji Ueda, Toshihiko Kuroda, et al. "Abstract C143: Expression profiles of miRNA, FFPE, and nonamplified samples for diagnostic tests using a supersensitive microarray." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-c143.

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Takizawa, Satoko, Hiroko Sudo, Yoji Ueda, et al. "Abstract LB-328: Highly sensitive detection of miRNA and mRNA from frozen, FFPE tissue and body fluid samples by expression microarray." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-lb-328.

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Sakuragi, Noriaki, Mohamed Kamel Farah, Zeinab Mohamed, et al. "Abstract LB-323: Comparative miRNA microarray profiling indicates miR-363 promotes chemoresistance in ovarian cancer cells by targeting the Hippo member, LATS2." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-lb-323.

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Dachuan Liu, Cuihong Dai, and Dechang Xu. "Cluster analysis of MiRNAs microarray data and prediction of lupeol's anti-cancer path." In 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW). IEEE, 2011. http://dx.doi.org/10.1109/bibmw.2011.6112411.

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Laurila, Eeva, Saana Sandstrom, Reija Autio, and Anne Kallioniemi. "Abstract 3043: Microarray based profiling reveals a distinct set of differentially expressed miRNAs in pancreatic cancer." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3043.

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Hyunsun, Kim, Jae-Jin Choi, Minhye cho, and Heekyung Park. "Abstract 3008: PNA based microarray for cancer & stem cell related miRNAs profiling from low total RNA with on-chip labeling." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3008.

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"Abstract P2-09-05: Screening of significantly hypermethylated genes in breast cancer using MIRA-based microarray and identifying their expression levels." In Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p2-09-05.

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