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Journal articles on the topic 'MiRNA microarray'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Nersisyan, Stepan, Maxim Shkurnikov, Andrey Poloznikov, et al. "A Post-Processing Algorithm for miRNA Microarray Data." International Journal of Molecular Sciences 21, no. 4 (2020): 1228. http://dx.doi.org/10.3390/ijms21041228.

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One of the main disadvantages of using DNA microarrays for miRNA expression profiling is the inability of adequate comparison of expression values across different miRNAs. This leads to a large amount of miRNAs with high scores which are actually not expressed in examined samples, i.e., false positives. We propose a post-processing algorithm which performs scoring of miRNAs in the results of microarray analysis based on expression values, time of discovery of miRNA, and correlation level between the expressions of miRNA and corresponding pre-miRNA in considered samples. The algorithm was succe

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Palmieri, Annalisa, Furio Pezzetti, Anna Avantaggiato, et al. "Titanium Acts on Osteoblast Translational Process." Journal of Oral Implantology 34, no. 4 (2008): 190–94. http://dx.doi.org/10.1563/0.869.1.

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Abstract Titanium is a highly biocompatible material and very osteogenic in vivo. However, how titanium regulates osteoblast activity to promote bone formation is incompletely characterized. We, therefore, attempted to get more information by using microRNA (miRNA) microarray techniques to investigate translation regulation in osteoblasts grown on titanium disks. The miRNA oligonucleotide microarray provides a novel method to carry out genome-wide miRNA profiling in human samples. By using miRNA microarrays containing 329 probes designed from the human miRNA sequence, several miRNA were identi

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Shaoqing, Yu, Zhang Ruxin, Liu Guojun, et al. "Microarray Analysis of Differentially Expressed microRNAs in Allergic Rhinitis." American Journal of Rhinology & Allergy 25, no. 6 (2011): e242-e246. http://dx.doi.org/10.2500/ajra.2011.25.3682.

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Background Allergic rhinitis (AR) is a common disease characterized by chronic inflammation of the nasal mucosa, but we have not fully understood the mechanism responsible for the development of AR. MicroRNAs (miRNAs) are short endogenous noncoding RNAs regulating protein translation through a mechanism known as RNA interference. To understand the molecular mechanisms of miRNA involved in the pathogenesis of AR, expressed miRNAs in AR were investigated through genomewide microarray analysis. Methods Mammalian miRNA microarrays containing whole human mature and precursor miRNA sequences were us

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Boštjančič, Emanuela, Nina Zidar, and Damjan Glavač. "MicroRNA Microarray Expression Profiling in Human Myocardial Infarction." Disease Markers 27, no. 6 (2009): 255–68. http://dx.doi.org/10.1155/2009/641082.

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MicroRNAs (miRNAs), small non-coding RNA molecules, are negative regulators of gene expression. Recent studies have indicated their role in various forms of cardiovascular disease. In spite of the number of miRNA microarray analyses performed, little is known about the genome-wide miRNA expression pattern in human myocardial infarction (MI). Using miRNA microarrays and bioinformatic analysis, miRNA expression was analyzed on human MI and foetal hearts compared to healthy adult hearts, to determine whether there is any similar expression pattern between MI and foetal hearts, and to identified m

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Yan, Naihong, Yilu Lu, Huaqin Sun, et al. "A microarray for microRNA profiling in mouse testis tissues." Reproduction 134, no. 1 (2007): 73–79. http://dx.doi.org/10.1530/rep-07-0056.

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MicroRNAs (miRNAs) are short non-coding RNA molecules playing regulatory roles by repressing translation or cleaving RNA transcripts. Recent studies indicate that miRNAs are mechanistically involved in the development of mammalian spermatogenesis. However, little work has been done to compare the miRNA expression patterns between immature and mature mouse testes. Here, we employed a miRNA microarray to detect 892 miRNAs in order to evaluate the expression patterns of miRNA. The expression of 19 miRNAs was significantly different between immature and mature individuals. Fourteen miRNAs were sig

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Wang, Shu-Ting, Cai Li, and Lei Liu. "miRNA Microarray Technology in miRNA Profiling." Current Bioinformatics 4, no. 2 (2009): 141–48. http://dx.doi.org/10.2174/157489309788184783.

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Huang, Xin, Chang Liu, Cuifang Hao, et al. "Identification of altered microRNAs and mRNAs in the cumulus cells of PCOS patients: miRNA-509-3p promotes oestradiol secretion by targeting MAP3K8." Reproduction 151, no. 6 (2016): 643–55. http://dx.doi.org/10.1530/rep-16-0071.

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Abstract Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women and is characterised by polycystic ovaries, hyperandrogenism and chronic anovulation. Although the clinical and biochemical signs of PCOS are typically heterogeneous, abnormal folliculogenesis is considered a common characteristic of PCOS. Our aim is to identify the altered miRNA and mRNA expression profiles in the cumulus cells of PCOS patients to investigate their molecular function in the aetiology and pathophysiology of PCOS. In this study, the miRNA expression profiles of the cumulus cell sampl

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Zhang, Yaping, Nan Ding, Hanlu Yi, et al. "Identification of differentially expressed miRNA 48 h after cerebral ischemia–reperfusion injury in mice by the technique of miRNA microarray." Canadian Journal of Physiology and Pharmacology 98, no. 12 (2020): 855–60. http://dx.doi.org/10.1139/cjpp-2019-0701.

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The objective was to identify the differential expressed miRNA during cerebral ischemia–reperfusion injury (CIRI) process, thereby assisting in elucidating the mechanism of CIRI development and providing a potential target for CIRI prevention and treatment. Six mice were randomly assigned to two groups: control group and CIRI model group. A global cerebral IR model by four-vessel occlusion was prepared among the CIRI model group. Brain tissues were collected 48 h after reperfusion. Total RNA was extracted for each sample. miRNA microarrays were employed to detect the differentially expressed m

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Vartanian, Keri B., Hugh D. Mitchell, Susan L. Stevens, Valerie K. Conrad, Jason E. McDermott, and Mary P. Stenzel-Poore. "CpG Preconditioning Regulates Mirna Expression That Modulates Genomic Reprogramming Associated with Neuroprotection against Ischemic Injury." Journal of Cerebral Blood Flow & Metabolism 35, no. 2 (2014): 257–66. http://dx.doi.org/10.1038/jcbfm.2014.193.

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Cytosine-phosphate-guanine (CpG) preconditioning reprograms the genomic response to stroke to protect the brain against ischemic injury. The mechanisms underlying genomic reprogramming are incompletely understood. MicroRNAs (miRNAs) regulate gene expression; however, their role in modulating gene responses produced by CpG preconditioning is unknown. We evaluated brain miRNA expression in response to CpG preconditioning before and after stroke using microarray. Importantly, we have data from previous gene microarrays under the same conditions, which allowed integration of miRNA and gene express

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Weishaupt, Sonja U., Steffen Rupp, and Karin Lemuth. "Simultaneous Detection of Different MicroRNA Types Using the ZIP-Code Array System." Journal of Nucleic Acids 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/496425.

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MicroRNAs (miRNAs) are important negative regulators of gene expression. Their implication in tumorigenesis is based on their dysregulation in many human cancer diseases. Interestingly, in tumor cells, an altered ratio of precursor and mature miRNA levels has been described. Consequently, differences in miRNA type levels have a high potential as biomarkers and comparative high-throughput-based detection might permit a more accurate characterization of subtypes, especially in the case of very heterogeneous tumor entities. Several molecular methods exist for the detection of mature and precursor

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Wang, Tingting, Baorui Liu, and Yayi Hou. "Cell-free microRNA expression profiles in malignant effusion associated with patient survival in non-small cell lung cancer." Journal of Clinical Oncology 30, no. 30_suppl (2012): 13. http://dx.doi.org/10.1200/jco.2012.30.30_suppl.13.

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13 Background: MicroRNAs (miRNAs) expression is altered in cancer cells, and miRNAs could serve as diagnostic and prognostic biomarker for cancer patients. This study was designed to analyze circulating miRNAs expression in the malignant pleural effusion (MPE) and their association with patient survival in non-small cell lung cancer (NSCLC). Methods: Pleural effusion from 184 patients with NSCLC and MPE were collected. MiRNA microarray and bioinformatics interpretation were used to evaluate miRNA expression profiles in 10 NSCLC patients with different survival prognosis. Associations were vali

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Sokol, Lubomir, Myka Estes, Ann H. Williams, et al. "Myelodysplastic Syndromes (MDS) Display a Risk and Senescence-Dependent MicroRNA (miRNA) Signature." Blood 108, no. 11 (2006): 2630. http://dx.doi.org/10.1182/blood.v108.11.2630.2630.

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Abstract MDS comprise a spectrum of senescence-dependent stem cell malignancies with cytogenetic abnormalities characterized by segmental or numerical chromosome deletion or duplication. Accumulation of genetic events with age has been implicated in MDS pathogenesis. MiRNAs are short non-coding double-stranded RNAs that regulate the posttranscriptional gene expression. Expression profiling has shown that miRNA signatures are tumor specific and may have a role in leukemia pathogenesis. We hypothesized that altered regulation of miRNA expression in hematopoietic progenitors plays a critical role

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Asa’ad, Farah, Carlos Garaicoa-Pazmiño, Christer Dahlin, and Lena Larsson. "Expression of MicroRNAs in Periodontal and Peri-Implant Diseases: A Systematic Review and Meta-Analysis." International Journal of Molecular Sciences 21, no. 11 (2020): 4147. http://dx.doi.org/10.3390/ijms21114147.

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Aim: The purpose of this review was to evaluate the expression patterns of miRNAs in periodontal and peri-implant diseases, while identifying potential miRNAs with the greatest diagnostic ability as an oral fluid biomarker. Materials and methods: Human and animal studies were included when evaluating expression of miRNAs between health and different forms/stages of diseases, in which microarray and/or real-time polymerase chain reaction (RT-PCR) was carried out to detect fold changes in gene expression. After full-text analysis, 43 articles were considered for a qualitative assessment, and 16

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Li, Xiao, Xu Feng, Chunkang Chang, Qi He, and Wu Lingyun. "Identification of microRNA-Regulated Pathways through a Integration of Mcrorna-mRNA Microarray and Bioinformatics Analysis in CD34+ Cells of Myelodysplastic Syndromes." Blood 124, no. 21 (2014): 3238. http://dx.doi.org/10.1182/blood.v124.21.3238.3238.

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Abstract Background MicroRNAs (miRNAs) are considered to play a key role in the pathogenesis of myelodysplastic syndromes (MDS). However, the effect of miRNA and targeted mRNA on signal transduction is not fully understood in MDS. Objective The objective of this study is to identify the miRNAs-regulated pathways. Methods Affymetrix GeneChip microRNA and PrimeView Array were used to analyze miRNAs and gene expression profile of CD34+ cells in 12 MDS patients and 6 healthy controls. Comprehensive bioinformatics analysis of the coordinate expression of miRNAs and mRNAs including Difference, Go, P

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Cojocneanu, Roxana, Cornelia Braicu, Lajos Raduly, et al. "Plasma and Tissue Specific miRNA Expression Pattern and Functional Analysis Associated to Colorectal Cancer Patients." Cancers 12, no. 4 (2020): 843. http://dx.doi.org/10.3390/cancers12040843.

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An increasing number of studies suggest the implication of microRNAs (miRNAs) in colorectal (CRC) carcinogenesis and disease progression. Nevertheless, the basic mechanism is not yet clear. We determined plasma miRNA expression levels using Agilent microarray technology followed by overlapping with The Cancer Genome Atlas (TCGA) tissue data and a qRT-PCR validation step and analysis of the altered miRNA signatures to emphasize new mechanistic insights. For TGCA dataset, we identified 156 altered miRNAs (79 downregulated and 77 upregulated) in colorectal tissue samples versus normal tissue. The

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Zhang, Lu, Huihui Li, Ming Yuan, Dong Li, Chang Sun, and Guoyun Wang. "Serum Exosomal MicroRNAs as Potential Circulating Biomarkers for Endometriosis." Disease Markers 2020 (January 29, 2020): 1–10. http://dx.doi.org/10.1155/2020/2456340.

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Background. A reliable noninvasive biomarker is not yet available for endometriosis diagnosis. Novel biomarkers for the diagnosis of endometriosis are urgently needed. The molecular constituents of exosomes, especially exosomal microRNAs (miRNAs), have considerable potential as novel biomarkers for clinical diagnosis. This study is aimed at exploring aberrant exosomal miRNA profiles by using miRNA microarray and at providing more accurate molecular biomarkers of endometriosis. Methods. Exosomes were isolated from the serum of patients with endometriosis and negative controls and identified by

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Laudanski, P., R. Charkiewicz, A. Tolwinska, J. Szamatowicz, A. Charkiewicz, and J. Niklinski. "Profiling of Selected MicroRNAs in Proliferative Eutopic Endometrium of Women with Ovarian Endometriosis." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/760698.

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It has been well documented that aberrant expression of selected microRNAs (miRNAs) might contribute to the pathogenesis of disease. The aim of the present study is to compare miRNA expression by the most comprehensive locked-nucleic acid (LNA) miRNA microarray in eutopic endometrium of patients with endometriosis and control. In the study we recruited 21 patients with endometriosis and 25 were disease-free women. The miRNA expression profiles were determined using the LNA miRNA microarray and validated for selected molecules by real-time PCR. We identified 1198 human miRNAs significantly diff

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Ren, Chengda, Qingyu Liu, Qingquan Wei, et al. "Circulating miRNAs as Potential Biomarkers of Age-Related Macular Degeneration." Cellular Physiology and Biochemistry 41, no. 4 (2017): 1413–23. http://dx.doi.org/10.1159/000467941.

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Backgroud: Age-related macular degeneration (AMD) is one of the leading causes of irreversible blindness of the elder people. This research was intended to demonstrate the different expression of microRNAs (miRNA) in AMD patients and whether they can be used as biomarkers for AMD. Methods: MiRNAs expression was measured by microarray of 6 AMD cases and 6 gender matched controls. In a larger-sample case-control study with 126 AMD cases and 140 controls, whole blood samples were detected for the differences of miRNA expression. Results: A total of 216 differentially expressed miRNAs (111 increas

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Qin, Qiu, Xuan Wang, Ni Yan, et al. "Aberrant Expression of miRNA and mRNAs in Lesioned Tissues of Graves' Disease." Cellular Physiology and Biochemistry 35, no. 5 (2015): 1934–42. http://dx.doi.org/10.1159/000374002.

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Background and Aims: Abnormal microRNA (miRNA) expression is found in many diseases including autoimmune diseases. However, little is known about the role of miRNA regulation in Graves' disease (GD). Here, we simultaneously detected different expressions of miRNA and mRNAs in thyroid tissues via a high-throughput transcriptomics approach, known as microarray, in order to reveal the relationship between aberrant expression of miRNAs and mRNAs spectrum and GD. Methods: Totally 7 specimens of thyroid tissue from 4 GD patients and 3 controls were obtained by surgery for microarray analysis. Then,

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McIver, S. C., S. D. Roman, B. Nixon, and E. A. McLaughlin. "142. microRNA AND EARLY MALE GERM CELLS." Reproduction, Fertility and Development 22, no. 9 (2010): 60. http://dx.doi.org/10.1071/srb10abs142.

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MicroRNAs are short regulatory noncoding RNA molecules that bind to the 3′ untranslated region of mRNA targets to control translation therefore influencing the abundance of many different protein molecules. Aberrant expression of miRNA is linked to many diseases and developmental abnormalities. Testicular Germ Cell Tumours (TGCT) develop from Carcinoma in situ cells which have been identified as dysfunctional gonocytes. Due to the continual rise in the rate of testicular cancer in the developed world, the molecular mechanisms underlying the failure of gonocytes to differentiate into spermatogo

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Guo, Na, Wen-Wu Ye, Xiao-Ling Wu, et al. "Microarray profiling reveals microRNAs involving soybean resistance to Phytophthora sojae." Genome 54, no. 11 (2011): 954–58. http://dx.doi.org/10.1139/g11-050.

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MicroRNAs (miRNAs), a group of small noncoding RNAs, may serve as a class of post-transcriptional regulators in plant immune systems. Nevertheless, little is known about their roles in plant immune response to the oomycete pathogens. To identify miRNAs involved in the response of soybean to Phytophthora sojae , we examined expressional patterns of miRNAs upon infection by P. sojae by microarray analysis in three soybean cultivars: Williams (susceptible), Conrad (quantitative resistance), and Williams 82 (qualitative resistance). Expression of a number of miRNAs was significantly altered upon i

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Li, Yingyuan, Wulin Tan, Fang Ye, et al. "Identification of microRNAs and genes as biomarkers of atrial fibrillation using a bioinformatics approach." Journal of International Medical Research 47, no. 8 (2019): 3580–89. http://dx.doi.org/10.1177/0300060519852235.

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Objective We aimed to explore potential microRNAs (miRNAs) and target genes related to atrial fibrillation (AF). Methods Data for microarrays GSE70887 and GSE68475, both of which include AF and control groups, were downloaded from the Gene Expression Omnibus database. Differentially expressed miRNAs between AF and control groups were identified within each microarray, and the intersection of these two sets was obtained. These miRNAs were mapped to target genes in the miRNet database. Functional annotation and enrichment analysis of these target genes was performed in the DAVID database. The pr

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He, Hang, Yang Di, Min Rui Liang, et al. "MicroRNA-218: A potential regulator of lymphatic metastasis in pancreatic ductal adenocarcinoma." Journal of Clinical Oncology 30, no. 15_suppl (2012): e14651-e14651. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e14651.

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e14651 Background: Early lymph node metastasis is one of the most important characteristic features of pancreatic ductal adenocarcinoma (PDAC) with a dismal prognosis. MicroRNAs (miRNAs) have been shown to have a role in oncogenesis, invasion, and metastasis via epigenetic posttranscriptional gene regulation. However lymphatic metastasis related miRNAs of pancreatic cancer (PC) has not been well documented. Methods: Through microarray analysis aberrantly expressing miRNAs potentially regulating lymphatic metastasis in PC were gained from PDAC tissue specimens and cell lines. Candidate miRNAs w

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Garzon, Ramiro, Stefano Volinia, Chang-Gong Liu, et al. "MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia." Blood 111, no. 6 (2008): 3183–89. http://dx.doi.org/10.1182/blood-2007-07-098749.

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Abstract MicroRNAs (miRNAs) are small RNAs of 19 to 25 nucleotides that are negative regulators of gene expression. To determine whether miRNAs are associated with cytogenetic abnormalities and clinical features in acute myeloid leukemia (AML), we evaluated the miRNA expression of CD34+ cells and 122 untreated adult AML cases using a microarray platform. After background subtraction and normalization using a set of housekeeping genes, data were analyzed using Significance Analysis of Microarrays. An independent set of 60 untreated AML patients was used to validate the outcome signatures using

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Bhaskaran, Manoj, Yang Wang, Honghao Zhang, et al. "MicroRNA-127 modulates fetal lung development." Physiological Genomics 37, no. 3 (2009): 268–78. http://dx.doi.org/10.1152/physiolgenomics.90268.2008.

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MicroRNAs (miRNAs) are small endogenous RNAs and are widely regarded as one of the most important regulators of gene expression in both plants and animals. To define the roles of miRNAs in fetal lung development, we profiled the miRNA expression pattern during lung development with a miRNA microarray. We identified 21 miRNAs that showed significant changes in expression during lung development. These miRNAs were grouped into four distinct clusters based on their expression pattern. Cluster 1 contained miRNAs whose expression increased as development progressed, while clusters 2 and 3 showed th

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Holliday, Casey J., Randall F. Ankeny, Hanjoong Jo, and Robert M. Nerem. "Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 3 (2011): H856—H867. http://dx.doi.org/10.1152/ajpheart.00117.2011.

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The role of endothelial cells (ECs) in aortic valve (AV) disease remains relatively unknown; however, disease preferentially occurs in the fibrosa. We hypothesized oscillatory shear (OS) present on the fibrosa stimulates ECs to modify mRNAs and microRNAs (miRNAs) inducing disease. Our goal was to identify mRNAs and miRNAs differentially regulated by OS and laminar shear (LS) in human AVECs (HAVECs) from the fibrosa (fHAVECs) and ventricularis (vHAVECs). HAVECs expressed EC markers as well as some smooth muscle cell markers and functionally aligned with the flow. HAVECs were exposed to OS and L

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Akagi, Ichiro, Osamu Ishibashi, Takeshi Matsutani, et al. "Comprehensive Analysis of MicroRNA and mRNA Expression in Normal and Tumorous Human Esophageal Squamous Cell Lines Using Microarray Datasets." Dataset Papers in Science 2014 (December 15, 2014): 1–3. http://dx.doi.org/10.1155/2014/376541.

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Despite the undisputed importance of altered microRNA (miRNA) expression in various cancers, there is limited information on the clinicopathologic significance of cancer-related miRNAs in esophageal squamous cell carcinoma (ESCC). Previously, it was reported that the expression of several miRNAs was dysregulated in ESCC. However, the target genes of these miRNAs have not been identified. Furthermore, additional miRNAs in humans have been discovered recently, indicating that revised miRNA and gene expression profiling for ESCC are necessary. Here, we provide datasets from microarray analyses to

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Pérez-Cremades, Daniel, Ana B. Paes, Xavier Vidal-Gómez, Ana Mompeón, Carlos Hermenegildo, and Susana Novella. "Regulatory Network Analysis in Estradiol-Treated Human Endothelial Cells." International Journal of Molecular Sciences 22, no. 15 (2021): 8193. http://dx.doi.org/10.3390/ijms22158193.

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Background/Aims: Estrogen has been reported to have beneficial effects on vascular biology through direct actions on endothelium. Together with transcription factors, miRNAs are the major drivers of gene expression and signaling networks. The objective of this study was to identify a comprehensive regulatory network (miRNA–transcription factor–downstream genes) that controls the transcriptomic changes observed in endothelial cells exposed to estradiol. Methods: miRNA/mRNA interactions were assembled using our previous microarray data of human umbilical vein endothelial cells (HUVEC) treated wi

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Lan, Chuangxin, Dong Chen, Xiongfa Liang, et al. "Integrative Analysis of miRNA and mRNA Expression Profiles in Calcium Oxalate Nephrolithiasis Rat Model." BioMed Research International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/8306736.

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The microRNA (miRNA) expression profiles and their biological functions in calcium oxalate nephrolithiasis remain unclear. In this study, we investigate the miRNA and mRNA expression profiles of kidney tissues in calcium oxalate stone rats. 16 Sprague Dawley rats were divided into control group and stone-forming group. 24-hour urine samples and kidney tissues were collected for biochemical and histological determination after 4 weeks. MiRNA and mRNA microarray were applied to evaluate the miRNA and mRNA expression profiles. To validate the microarray results, the quantitative real-time PCR (qR

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Wang, Lei, Shengpan Chen, Yan Liu, et al. "The biological and diagnostic roles of MicroRNAs in meningiomas." Reviews in the Neurosciences 31, no. 7 (2020): 771–78. http://dx.doi.org/10.1515/revneuro-2020-0023.

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AbstractMicroRNAs (miRNAs) refer to a class of small endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level. Emerging studies have shown that miRNAs play critical roles in tumorigenesis and cancer progression. However, roles and mechanisms of miRNA dysregulation in the pathogenesis of meningioma are not fully understood. Here, we first reviewed existing research of aberrantly expressed miRNAs identified by high throughput microarray profiling in meningioma. We also explored the potential of miRNA as biomarkers and therapeutic targets for novel treatment para

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Peng, Yan, Xianwen Zhang, Yuewu Liu, and Xinbo Chen. "Exploring Heat-Response Mechanisms of MicroRNAs Based on Microarray Data of Rice Post-meiosis Panicle." International Journal of Genomics 2020 (September 18, 2020): 1–13. http://dx.doi.org/10.1155/2020/7582612.

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To explore heat response mechanisms of mircoRNAs (miRNAs) in rice post-meiosis panicle, microarray analysis was performed on RNA isolated from rice post-meiosis panicles which were treated at 40°C for 0 min, 10 min, 20 min, 60 min, and 2 h. By integrating paired differentially expressed (DE) miRNAs and mRNA expression profiles, we found that the expression levels of 29 DE-miRNA families were negatively correlated to their 178 DE-target genes. Further analysis showed that the majority of miRNAs in 29 DE-miRNA families resisted the heat stress by downregulating their target genes and a time lag

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Zhang, Haojie, Qien Qi, Ting Chen, et al. "Age-Related Changes in MicroRNA in the Rat Pituitary and Potential Role in GH Regulation." International Journal of Molecular Sciences 19, no. 7 (2018): 2058. http://dx.doi.org/10.3390/ijms19072058.

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The growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis has recently been recognized as an important factor related to the longevity of many organisms. MicroRNAs (miRNAs or miRs) could also participate in diverse biological processes. However, the role of miRNAs in the decline of pituitary GH during the growth process remains unclear. To better characterize the effects of miRNAs on the pituitary, we used a miRNA microarray to investigate the miRNA profile in the rat pituitary from postnatal development throughout the growth process. Then, in vitro experiments were conducted to analyze

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Li, Cong-Jun, Robert W. Li, and Theodore H. Elsasser. "MicroRNA (miRNA) Expression is Regulated by Butyrate-Induced Epigenetic Modulation of Gene Expression in Bovine Cells." Genetics & Epigenetics 3 (January 2010): GEG.S6144. http://dx.doi.org/10.4137/geg.s6144.

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We present evidence that butyrate induced histone acetylation regulates miRNA expression. MicroRNA expression microarray profiling revealed that 35 miRNA transcripts are significantly ( P < 0.05) differentially expressed after cells were treated with 10 mM butyrate. Among them, 11 transcripts are differentially expressed very significantly ( P < 0.01). The functional and pathways analysis using MetaCore analytical suite shows differentially expressed miRNAs targeting some very important gene networks and differentially expressed miRNAs may interfere with butyrate induced modulation of ge

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Gu, Wei, Ying Sun, Xiong Zheng, et al. "Identification of Gastric Cancer-Related Circular RNA through Microarray Analysis and Bioinformatics Analysis." BioMed Research International 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/2381680.

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Gastric cancer is one of the common malignant tumors worldwide. Increasing studies have indicated that circular RNAs (circRNAs) play critical roles in the cancer progression and have shown great potential as useful markers and therapeutic targets. However, the precise mechanism and functions of most circRNAs are still unknown in gastric cancer. In the present study, we performed a microarray analysis to detect circRNA expression changes between tumor samples and adjacent nontumor samples. The miRNA expression profiles were obtained from the National Center of Biotechnology Information Gene Exp

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Bassani, Niccolò, Federico Ambrogi, and Elia Biganzoli. "Assessing Agreement between miRNA Microarray Platforms." Microarrays 3, no. 4 (2014): 302–21. http://dx.doi.org/10.3390/microarrays3040302.

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Omidi, Forouzan, Sayed Abdolhakim Hosseini, Abbas Ahmadi, et al. "Discovering the signature of a lupus-related microRNA profile in the Gene Expression Omnibus repository." Lupus 29, no. 11 (2020): 1321–35. http://dx.doi.org/10.1177/0961203320944473.

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Lupus is one of the most prevalent systemic autoimmune diseases. It is a multifactorial disease in which genetic, epigenetic and environmental factors play significant roles. The pathogenesis of lupus is not yet well understood. However, deregulation of microRNAs (miRNAs) – one of the post-transcriptional regulators of genes – can contribute to the development of autoimmune diseases. Over the last two decades, advances in the profiling of miRNA using microarray have received much attention, and it has been demonstrated that miRNAs play a regulatory role in the pathogenesis of lupus. Therefore,

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Zhu, Yuandong, Huan Zhu, Xiaobao Xie, Zhuojun Zheng, and Yun Ling. "MicroRNA expression profile in Treg cells in the course of primary immune thrombocytopenia." Journal of Investigative Medicine 67, no. 8 (2019): 1118–24. http://dx.doi.org/10.1136/jim-2019-001020.

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Primary immune thrombocytopenia (ITP) is an autoimmune bleeding disorder which characterizes with platelet production impairment and platelet destruction increment. CD4+CD25+Foxp3+ Treg cells (Tregs) are involved in the immune pathogenesis of ITP. MicroRNAs (miRNAs) are also involved in ITP and their loss of function is shown to facilitate immune disorders. Thus, the miRNA expression profile in Tregs from ITP was analyzed in this study. We assessed the genome-wide miRNA expression profile of three newly diagnosed adult patients with ITP and three healthy controls using microarray analysis of C

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Yan, Li, Demin Jiao, Huizhen Hu, et al. "Identification of lymph node metastasis-related microRNAs in lung adenocarcinoma and analysis of the underlying mechanisms using a bioinformatics approach." Experimental Biology and Medicine 242, no. 7 (2016): 709–17. http://dx.doi.org/10.1177/1535370216677353.

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This study aimed to screen lymphatic metastasis-related microRNAs (miRNAs) in lung adenocarcinoma and explore their underlying mechanisms using bioinformatics. The miRNA expression in primary lung adenocarcinoma, matched adjacent non-tumorigenic and lymph node metastasis tissues of patients were profiled via microarray. The screened metastasis-related miRNAs were then validated using quantitative real-time PCR in a second cohort of lung adenocarcinoma patients with lymphatic metastasis. Significance was determined using a paired t-test. Target genes of the metastasis-related miRNAs were predic

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Xiao, Hui, Rui Huang, Mei Diao, Long Li, and XiaoDai Cui. "Integrative analysis of microRNA and mRNA expression profiles in fetal rat model with anorectal malformation." PeerJ 6 (October 24, 2018): e5774. http://dx.doi.org/10.7717/peerj.5774.

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Background Anorectal malformations (ARMs) are the most common congenital malformation of the gut, and regulated by multiple signal transduction pathways. The microRNA (miRNA) expression profiles and their biologial functions in anorectal malformations (ARMs) remain unclear. The aim of our study was to evaluate miRNA and mRNA expression profiles in the ARM rats. Methods and Materials ARM was induced with ethylenethiourea (ETU) on gestational day 10. Cesarean deliveries were performed to harvest the embryos on gestional day 20. For the extraction of total RNA, 1 cm terminal hindgut samples were

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Wang, Xian-min, Kui Zhang, Yan Li, et al. "Screening miRNA and their target genes related to tetralogy of Fallot with microarray." Cardiology in the Young 24, no. 3 (2013): 442–46. http://dx.doi.org/10.1017/s104795111300053x.

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AbstractOur aim is to screen miRNAs and genes related to tetralogy of Fallot and construct a co-expression network based on integrating miRNA and gene microarrays. We downloaded the gene expression profile GSE35490 (miRNA) and GSE35776 (mRNA) of tetralogy of Fallot from the Gene Expression Omnibus database, which includes eight normal and 15 disease samples from infants, and screened differentially expressed miRNAs and genes between normal and disease samples (cut-off: p < 0.05; FDR < 0.05; and log FC > 2 or log FC < −2); in addition, we downloaded human miRNA and their targets, wh

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Wilson, Michael, Nan Leng, Sachin Sah, Edward Sekinger, Frederick Fletcher, and Charles Johnson. "A High-Density MicroRNA Array for Analyzing the Expression of 15,090 Verified and Predicted Small, Non-Coding RNAs." Blood 108, no. 11 (2006): 4210. http://dx.doi.org/10.1182/blood.v108.11.4210.4210.

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Abstract We have designed and evaluated the performance of a custom Affymetrix microRNA (miRNA) microarray that enables the analysis of 15,090 unique mature miRNAs that are predicted or biologically verified. The comprehensive probe content of the array was selected from multiple sources including the Sanger miRBase sequence database (version 8.0), published reports, and a proprietary database of predicted miRNAs. Most of the ~31,000 25-mer probes on the array were designed by selecting two overlapping oligonucleotide sequences that span the mature miRNA sequences and a portion of the flanking

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Hermyt, Ewelina, Nikola Zmarzły, Beniamin Grabarek, et al. "Interplay between miRNAs and Genes Associated with Cell Proliferation in Endometrial Cancer." International Journal of Molecular Sciences 20, no. 23 (2019): 6011. http://dx.doi.org/10.3390/ijms20236011.

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Endometrial cancer develops as a result of abnormal cell growth associated with uncontrolled cell proliferation, excessive activation of signaling pathways and miRNA activity. The aim of this study was to determine the expression profile of genes associated with cell proliferation and to assess which miRNAs can participate in the regulation of their expression. The study enrolled 40 patients with endometrial cancer and 10 patients without neoplastic changes. The expression profile of genes associated with cell proliferation and the expression profile of miRNAs were assessed using microarrays.

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Castro, F. O., S. Sharbati, L. L. Rodríguez-Alvarez, J. F. Cox, C. Hultschig, and R. Einspanier. "49 REPROGRAMMING OF MICRO RNA IN BOVINE CLONED ELONGATED EMBRYOS." Reproduction, Fertility and Development 22, no. 1 (2010): 182. http://dx.doi.org/10.1071/rdv22n1ab49.

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MicroRNAs (miRNA) are key regulators of gene expression in vertebrate development; however, little information exists about their expression in pre-implantation mammalian embryos. We studied the expression of miRNA in bovine cloned and IVF-elongated embryos using microarrays and quantitative RT-PCR (qRT-PCR). Day-7 IVF or handmade cloned blastocysts from an adult cell line that previously yielded live cloned calves were transferred to synchronized heifers and recovered at Day 17 as elongated embryos. MicroRNAs were purified using miRVANA kit+Flash Page fractionator column (Ambion, Austin, TX,

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Chen, Jiajia, and Liangzhi Li. "Multiple Regression Analysis Reveals MicroRNA Regulatory Networks in Oryza sativa under Drought Stress." International Journal of Genomics 2018 (October 4, 2018): 1–12. http://dx.doi.org/10.1155/2018/9395261.

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Drought is a major abiotic stress that reduces rice development and yield. miRNAs (microRNAs) are known to mediate posttranscriptional regulation under drought stress. Although the importance of individual miRNAs has been established, the crosstalks between miRNAs and mRNAs remain unearthed. Here we performed microarray analysis of miRNAs and matched mRNA expression profiles of drought-treated rice cultivar Nipponbare. Drought-responsive miRNA-mRNA regulations were identified by a combination of a partial least square (PLS) regression approach and sequence-based target prediction. A drought-in

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Nair, Veena B., V. G. Manasa, M. S. Sinto, K. Jayasree, Francis V. James, and S. Kannan. "Differential Expression of MicroRNAs in Uterine Cervical Cancer and Its Implications in Carcinogenesis; An Integrative Approach." International Journal of Gynecologic Cancer 28, no. 3 (2018): 553–62. http://dx.doi.org/10.1097/igc.0000000000001203.

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ObjectivesCervical cancer is the second most common cancer in women in developing countries, including India. Recently, microRNAs (miRNAs) are gaining importance in cancer biology because of their involvement in various cellular processes. The present study aimed to profile miRNA expression pattern in cervical cancer, identify their target genes, and understand their role in carcinogenesis.MethodsHuman papillomavirus (HPV) infection statuses in samples were assessed by heminested polymerase chain reaction followed by direct DNA sequencing. Next-generation sequencing and miRNA microarray were u

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Velázquez-Fernández, David, Stefano Caramuta, Deniz M. Özata, et al. "MicroRNA expression patterns associated with hyperfunctioning and non-hyperfunctioning phenotypes in adrenocortical adenomas." European Journal of Endocrinology 170, no. 4 (2014): 583–91. http://dx.doi.org/10.1530/eje-13-0817.

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BackgroundThe adrenocortical adenoma (ACA) entity includes aldosterone-producing adenoma (APA), cortisol-producing adenoma (CPA), and non-hyperfunctioning adenoma (NHFA) phenotypes. While gene mutations and mRNA expression profiles have been partly characterized, less is known about the alterations involving microRNA (miRNA) expression.AimTo characterize miRNA expression profile in relation to the subtypes of ACAs.Subjects and methodsmiRNA expression profiles were determined in 26 ACAs (nine APAs, ten CPAs, and seven NHFAs) and four adrenal references using microarray-based screening. Signific

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San-Marina, Serban, Fernando Suarez Saiz, Haytham Khoury, and Mark D. Minden. "Aberrant Co-Expression of Micrornas and Host Genes in Leukemia: Evidence for a Common Transcript from Meta-Analysis and Microarray Data." Blood 108, no. 11 (2006): 2232. http://dx.doi.org/10.1182/blood.v108.11.2232.2232.

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Abstract In leukemia, the integrity of the transcriptome is altered by chromosomal translocations, deletions, duplications, as well as by epigenetic changes in chromatin structure. By targeting mRNAs for translational repression or RNase-dependent hydrolysis (AU-rich miRNAs or shRNA-like effects), the micro RNA (miRNA) component of the transcriptome is estimated to regulate expression of up to 30% of all proteins. Yet the causes and role of deregulated miRNA expression in malignancy are largely unknown, in part because promoter events are not characterized. Since more than one-third of all kno

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Ortega, Francisco J., Josep M. Mercader, José M. Moreno-Navarrete, et al. "Surgery-Induced Weight Loss Is Associated With the Downregulation of Genes Targeted by MicroRNAs in Adipose Tissue." Journal of Clinical Endocrinology & Metabolism 100, no. 11 (2015): E1467—E1476. http://dx.doi.org/10.1210/jc.2015-2357.

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Context: Molecular mechanisms associated with physiological variations in adipose tissue (AT) are not fully recognized. The most recent reports highlight the critical relevance of microRNAs (miRNAs) found in AT. Objective: To identify changes in messenger RNA (mRNA) and miRNA expressions and their interaction in human AT before and after surgery-induced weight loss. Research Design and Setting: Genome-wide mRNA and miRNA expressions were assessed by microarrays in abdominal subcutaneous AT of 16 morbidly obese women before and 2 years after laparoscopic Roux-en-Y gastric bypass. The associatio

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Zhang, Yibing, Xiaoyan Ma, Xiangjun Li, Tong Zhang, Meng Qin, and Liqun Ren. "Effects of Icariin on Atherosclerosis and Predicted Function Regulatory Network in ApoE Deficient Mice." BioMed Research International 2018 (November 6, 2018): 1–12. http://dx.doi.org/10.1155/2018/9424186.

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Objective. Icariin plays a pivotal role in ameliorating atherosclerosis for animal models although its comprehensive biological role remains largely unexplored. This study aimed to fully understand the effects of icariin on atherosclerosis in high-fat diet-induced ApoE-/- mice and investigate mRNA-miRNA regulation based on microarray and bioinformatics analysis. Methods. The areas of atherosclerotic lesions in en face aorta were evaluated. Microarray analysis was performed on atherosclerotic aortic tissues. The integrative analysis of mRNA and miRNA profiling was utilized to suggest specific f

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Chng, Wee-Joo, Junli Yan, Gaofeng Huang, et al. "Dysregulated MicroRNA Affects Pathways and Targets of Biological Relevance in Nasal-Type Natural Killer/T-Cell Lymphoma." Blood 118, no. 21 (2011): 2637. http://dx.doi.org/10.1182/blood.v118.21.2637.2637.

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Abstract Abstract 2637 Background: Extranodal nasal-type Natural Killer/T-cell lymphoma (NKTL) is a relatively rare but aggressive type of non-Hodgkins lymphoma that is more prevalent in Asia. The outcome of patients with disseminated stage is universally fatal. Progress in therapy has been slow and is based on combination of chemotherapy. MicroRNA are short non-coding RNA sequences that could regulate the expression of a large number of genes by inhibiting translation or leading to mRNA degradation. It has been implicated in tumorigenesis and has prognostic value across a wide range of malign

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