Academic literature on the topic 'Mis-register'

This paper throws light on comparative quality evaluationof print quality of various newspapers. Quality has been major concern among various newspapers since last many decades. During the production there are a lot of factors which causes deviation in quality and some defects arise sequentially. Quality mapping was performed for different newspapers i.e. HT, TOI, Hindustan and Dainik Jagran for one month. The various factors taken into consideration for quality mapping were mis-register, density issues, set off, folding issues,show-through and picture quality. The quality mapping was based on the observation of a no. of readers. The results indicated that Dainik Jagran was having maximum number of quality issues compares to others. HT was found the best among all the newspapers.

(1) Background: Currently, multisystem inflammatory syndrome in children (MIS-C) is diagnosed based on clinical symptoms and laboratory findings of inflammation in the body. Once MIS-C is diagnosed, children will need to be followed over time. The imaging modalities most commonly used in the evaluation of patients with MIS-C include radiographs, ultrasound (US), and computed tomography (CT). Our study aims to summarise the literature data for the main gastrointestinal and pulmonary imaging features in children diagnosed with MIS-C and to share a single-centre experience. (2) Methods: We present the imaging findings in a cohort of 51 children diagnosed with MIS-C, admitted between December 2020 and February 2022. Imaging studies include chest and abdominal radiographs, thoracic, abdominal, and neck US and echocardiography (ECHO), and CT of the chest, abdomen, and pelvis. (3) Results: In accordance with the results in other studies, our observations show predominantly gastrointestinal involvement (GI) with ascites (33/51, 65%) and lymphadenopathy (19/51, 37%), ileitis or colitis (18/51, 35%), some cases of splenomegaly (9/51, 18%), hepatomegaly (8/51, 16%), and a few cases of renal enlargement (3/51, 6%) and gallbladder fossa oedema/wall thickening (2/51, 4%). Most common among the thoracic findings are posterior–basal consolidations (16/51, 31%), pleural effusion (14/51, 27%), and ground-glass opacities (12/51, 24%). We also register the significant involvement of the cardiovascular system with pericarditis (30/51, 58%), pericardial effusion (16/51, 31%), and myocarditis (6/51, 12%). (4) Conclusions: Radiologists should be aware of those imaging findings in order to take an important and active role not only in applying an accurate diagnosis, but also in the subsequent management of children with MIS-C. Radiological findings are not the primary diagnostic tool, but can assist in the evaluation of the affected systems and guide treatment.

Objective: To perform a systematic review assessing the impact of the different management options on health-related quality of life (HRQoL) of patients with localized renal masses or renal cell carcinomas (LRM/LRCC). Materials and Methods: Searches covering PubMed, Embase (Ovid), CENTRAL, PsycINFO (Ovid), CINAHL (EBSCO), and Cochrane Central Register of Controlled Trials (CENTRAL) databases was conducted for papers published up to 25 April 2021. Methods as per Cochrane Handbook were followed. “Modality” of treatment included radical nephrectomy (RN), nephron-sparing surgery (NSS), thermal ablation (TA), and active surveillance (AS). “Approach” was categorized as open incision and minimally invasive surgery (MIS). Risk of bias was assessed by ROBINS-I and Cochrane RoB 2 for observational studies and randomized controlled trials, respectively and certainty of the evidence by GRADE. Results: Sixteen observational studies and 1 randomized controlled trial (2.370 patients) met inclusion criteria. Fifteen different patient reported outcome measures (PROMs) were identified. Heterogeneity prevented quantitative analysis. Generic HRQoL decreases after RN and NSS, recovers within 6 to 12 months, and mostly overlaps with baseline values, irrespective of modality. Cancer-specific HRQoL improve faster after open-NSS than open-RN. The detrimental effect of RN may persist long-term in cross-evaluations. QoL scales significantly decrease after open surgery and MIS during the first weeks but improve faster after MIS. They are similar for both approaches at 1-year. Long-term cancer-specific QoL is similar for MIS and open procedures. Fear of recurrence is lower in older patients and affected by neither modality nor approach. Conclusions: Low quality evidence supports the use of MIS over the open approach when HRQoL is considered in the management of LRMs/LRCCs; data regarding the effect of the treatment modality of the LRM/LRCC show contradictory outcomes.

OBJECTIVE Lumbar stenosis treatment has evolved with the introduction of minimally invasive surgery (MIS) techniques. Endoscopic methods take the concepts applied to MIS a step further, with multiple studies showing that endoscopic techniques have outcomes that are similar to those of more traditional approaches. The aim of this study was to perform an updated meta-analysis and systematic review of studies comparing the outcomes between endoscopic (uni- and biportal) and microscopic techniques for the treatment of lumbar stenosis. METHODS Following PRISMA guidelines, a systematic search was performed using the Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Ovid Embase, and PubMed databases from their dates of inception to December 14, 2020. All identified articles were then systematically screened against the following inclusion criteria: 1) studies comparing endoscopic (either uniportal or biportal) with minimally invasive approaches, 2) patient age ≥ 18 years, and 3) diagnosis of lumbar spinal stenosis. Bias was assessed using quality assessment criteria and funnel plots. Meta-analysis using a random-effects model was used to synthesize the metadata. RESULTS From a total of 470 studies, 14 underwent full-text assessment. Of these 14 studies, 13 comparative studies were included for quantitative analysis, totaling 1406 procedures satisfying all criteria for selection. Regarding postoperative back pain, 9 studies showed that endoscopic methods resulted in significantly lower pain scores compared with MIS (mean difference [MD] −1.0, 95% CI −1.6 to −0.4, p < 0.01). The length of stay data were reported by 7 studies, with endoscopic methods associated with a significantly shorter length of stay versus the MIS technique (MD −2.1 days, 95% CI −2.7 to −1.4, p < 0.01). There was no significant difference with respect to leg visual analog scale scores, Oswestry Disability Index scores, blood loss, surgical time, and complications, and there were not any significant quality or bias concerns. CONCLUSIONS Both endoscopic and MIS techniques are safe and effective methods for treating patients with symptomatic lumbar stenosis. Patients who undergo endoscopic surgery seem to report less postoperative low-back pain and significantly reduced hospital stay with a trend toward less perioperative blood loss. Future large prospective randomized trials are needed to confirm the findings in this study.

Introduction: Mastocytosis is a heterogeneous chronic disease caused by a mutation in the cKIT gene that allows for uncontrolled proliferation, accumulation and activation of abnormal mast cells. Mastocytosis is divided into cutaneous mastocytosis (CM) and systemic mastocytosis (SM) in which abnormal mast cells are found in various tissues of the body. SM is further divided into the following five subtypes related to disease severity: indolent systemic mastocytosis (ISM), smoldering systemic mastocytosis (SSM), aggressive systemic mastocytosis (ASM), systemic mastocytosis with an associated hematologic neoplasm (SM-AHN) and mast cell leukemia (MCL). Mastocytosis is considered a rare disease with an incidence and prevalence previously found to be 0,89 per 100.000 and 9,59 per 100.000, respectively; however, recent improvements related to diagnostic methods could have led to an increased incidence and prevalence. Therefore, updated data is needed. Methods: This study is a retrospective nationwide register study including all adult (≥18 years) patients with mastocytosis in Denmark diagnosed between January 1 st 1997 and December 31 st 2021. The study was conducted using the Danish Civil Registration System to merge data from the National Patient Register (NPR), the Danish Pathology Register (DPR) and the Danish Cancer Register (DCR). The National Patient Register contain information on all inpatient and outpatient contacts and is considered complete as of 1995-2018. The Danish Pathology Register contain information about all biopsies and pathologic examinations in Denmark and is considered complete as of 1997 to 2021. The Danish Cancer Register contain information on all incidences of cancer in Denmark and is considered complete as of 1987-2021. Year of diagnosis was considered as the earliest date across all registers and patients were categorized as most severe subtype of mastocytosis. The registers did not allow for a categorization of SSM and therefore indolent mastocytosis were all categorized as ISM. Patients without a positive extracutaneous biopsy and who have never been examined with a bone marrow biopsy were classified as mastocytosis in the skin (MIS). Results: These data are the preliminary results of this study. 1627 patient were included (female 924, 56,8%). Mastocytosis in the skin was the most prevalent type of mastocytosis (774, 47,57%), followed by ISM (441, 27,11%), CM (222, 13,64%) and SM-AHN (179, 11%), More than 80% of patients with ASM had another hematologic neoplasm and were categorized as SM-AHN. Few patients were classified as ASM (4, 0,25%) and MCL (7, 0,43%). A positive bone marrow biopsy was found among 601 (36,94%) of the patients; however, 774 (47,57%) patients with mastocytosis were not examined with a bone marrow biopsy. The incidence rate of mastocytosis (all subtypes) was lowest in 2003 with an incidence of 0,74 per 100.000. Hereafter, the incidence increased until reaching the highest level in 2018 with an incidence of 2,77 per 100.000 (figure 1). The 25-year limited-duration prevalence as of 1 st January 2022 was 28,44 per 100.000. Conclusion: This nationwide register study provides updated data on the prevalence and incidence of mastocytosis in Denmark. The incidence rate was found to have an increasing trend until 2018 when it reached the highest value of 2,77 per 100.000. The prevalence was found to be 28,44 and thereby higher than previous studies have found. However, the true prevalence is potentially higher as the data for the years 2019-2021 solely relies on the pathology register. This is preliminary data, and the results will be updated when the NPR is complete for these years.Further analysis will be conducted using the Register of Laboratory Results for Research to evaluate blood tests regarding tryptase levels as well as to provide further information regarding KIT mutational status.