To see the other types of publications on this topic, follow the link: Mis-register.
Journal articles on the topic 'Mis-register'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Mis-register.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Castledine, George. "Staff nurse removed from nursing register for mis-management of drug rounds." British Journal of Nursing 14, no. 18 (2005): 953. http://dx.doi.org/10.12968/bjon.2005.14.18.19879.
Full text
2
Ms., Swati*1 &. Mr. Hitesh Garg2. "COMPARATIVE QUALITY MAPPING OF DIFFERENT NEWSPAPERS." INTERNATIONAL JOURNAL OF ENGINEERING SCIENCES & RESEARCH TECHNOLOGY 6, no. 7 (2017): 508–12. https://doi.org/10.5281/zenodo.829753.
Full textAbstract:
This paper throws light on comparative quality evaluationof print quality of various newspapers. Quality has been major concern among various newspapers since last many decades. During the production there are a lot of factors which causes deviation in quality and some defects arise sequentially. Quality mapping was performed for different newspapers i.e. HT, TOI, Hindustan and Dainik Jagran for one month. The various factors taken into consideration for quality mapping were mis-register, density issues, set off, folding issues,show-through and picture quality. The quality mapping was based on the observation of a no. of readers. The results indicated that Dainik Jagran was having maximum number of quality issues compares to others. HT was found the best among all the newspapers.
3
Ilieva, Elena, Vilyana Kostadinova, Iren Tzotcheva, Nadezhda Rimpova, Yordanka Paskaleva, and Snezhina Lazova. "Abdominal and Thoracic Imaging Features in Children with MIS-C." Gastroenterology Insights 13, no. 4 (2022): 313–25. http://dx.doi.org/10.3390/gastroent13040032.
Full textAbstract:
(1) Background: Currently, multisystem inflammatory syndrome in children (MIS-C) is diagnosed based on clinical symptoms and laboratory findings of inflammation in the body. Once MIS-C is diagnosed, children will need to be followed over time. The imaging modalities most commonly used in the evaluation of patients with MIS-C include radiographs, ultrasound (US), and computed tomography (CT). Our study aims to summarise the literature data for the main gastrointestinal and pulmonary imaging features in children diagnosed with MIS-C and to share a single-centre experience. (2) Methods: We present the imaging findings in a cohort of 51 children diagnosed with MIS-C, admitted between December 2020 and February 2022. Imaging studies include chest and abdominal radiographs, thoracic, abdominal, and neck US and echocardiography (ECHO), and CT of the chest, abdomen, and pelvis. (3) Results: In accordance with the results in other studies, our observations show predominantly gastrointestinal involvement (GI) with ascites (33/51, 65%) and lymphadenopathy (19/51, 37%), ileitis or colitis (18/51, 35%), some cases of splenomegaly (9/51, 18%), hepatomegaly (8/51, 16%), and a few cases of renal enlargement (3/51, 6%) and gallbladder fossa oedema/wall thickening (2/51, 4%). Most common among the thoracic findings are posterior–basal consolidations (16/51, 31%), pleural effusion (14/51, 27%), and ground-glass opacities (12/51, 24%). We also register the significant involvement of the cardiovascular system with pericarditis (30/51, 58%), pericardial effusion (16/51, 31%), and myocarditis (6/51, 12%). (4) Conclusions: Radiologists should be aware of those imaging findings in order to take an important and active role not only in applying an accurate diagnosis, but also in the subsequent management of children with MIS-C. Radiological findings are not the primary diagnostic tool, but can assist in the evaluation of the affected systems and guide treatment.
4
Sandbergen, Laura, Muhammad Imran Omar, Lavin Othman, et al. "Systematic Review of Comparative Patient Reported Outcomes and Health-Related Quality of Life After Management of Localized Renal Masses or Renal Cell Carcinomas." Société Internationale d’Urologie Journal 3, no. 4 (2022): 209–39. http://dx.doi.org/10.48083/qode9040.
Full textAbstract:
Objective: To perform a systematic review assessing the impact of the different management options on health-related quality of life (HRQoL) of patients with localized renal masses or renal cell carcinomas (LRM/LRCC). Materials and Methods: Searches covering PubMed, Embase (Ovid), CENTRAL, PsycINFO (Ovid), CINAHL (EBSCO), and Cochrane Central Register of Controlled Trials (CENTRAL) databases was conducted for papers published up to 25 April 2021. Methods as per Cochrane Handbook were followed. “Modality” of treatment included radical nephrectomy (RN), nephron-sparing surgery (NSS), thermal ablation (TA), and active surveillance (AS). “Approach” was categorized as open incision and minimally invasive surgery (MIS). Risk of bias was assessed by ROBINS-I and Cochrane RoB 2 for observational studies and randomized controlled trials, respectively and certainty of the evidence by GRADE. Results: Sixteen observational studies and 1 randomized controlled trial (2.370 patients) met inclusion criteria. Fifteen different patient reported outcome measures (PROMs) were identified. Heterogeneity prevented quantitative analysis. Generic HRQoL decreases after RN and NSS, recovers within 6 to 12 months, and mostly overlaps with baseline values, irrespective of modality. Cancer-specific HRQoL improve faster after open-NSS than open-RN. The detrimental effect of RN may persist long-term in cross-evaluations. QoL scales significantly decrease after open surgery and MIS during the first weeks but improve faster after MIS. They are similar for both approaches at 1-year. Long-term cancer-specific QoL is similar for MIS and open procedures. Fear of recurrence is lower in older patients and affected by neither modality nor approach. Conclusions: Low quality evidence supports the use of MIS over the open approach when HRQoL is considered in the management of LRMs/LRCCs; data regarding the effect of the treatment modality of the LRM/LRCC show contradictory outcomes.
5
Perez-Roman, Roberto J., Wendy Gaztanaga, Victor M. Lu, and Michael Y. Wang. "Endoscopic decompression for the treatment of lumbar spinal stenosis: an updated systematic review and meta-analysis." Journal of Neurosurgery: Spine 36, no. 4 (2022): 549–57. http://dx.doi.org/10.3171/2021.8.spine21890.
Full textAbstract:
OBJECTIVE Lumbar stenosis treatment has evolved with the introduction of minimally invasive surgery (MIS) techniques. Endoscopic methods take the concepts applied to MIS a step further, with multiple studies showing that endoscopic techniques have outcomes that are similar to those of more traditional approaches. The aim of this study was to perform an updated meta-analysis and systematic review of studies comparing the outcomes between endoscopic (uni- and biportal) and microscopic techniques for the treatment of lumbar stenosis. METHODS Following PRISMA guidelines, a systematic search was performed using the Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Ovid Embase, and PubMed databases from their dates of inception to December 14, 2020. All identified articles were then systematically screened against the following inclusion criteria: 1) studies comparing endoscopic (either uniportal or biportal) with minimally invasive approaches, 2) patient age ≥ 18 years, and 3) diagnosis of lumbar spinal stenosis. Bias was assessed using quality assessment criteria and funnel plots. Meta-analysis using a random-effects model was used to synthesize the metadata. RESULTS From a total of 470 studies, 14 underwent full-text assessment. Of these 14 studies, 13 comparative studies were included for quantitative analysis, totaling 1406 procedures satisfying all criteria for selection. Regarding postoperative back pain, 9 studies showed that endoscopic methods resulted in significantly lower pain scores compared with MIS (mean difference [MD] −1.0, 95% CI −1.6 to −0.4, p < 0.01). The length of stay data were reported by 7 studies, with endoscopic methods associated with a significantly shorter length of stay versus the MIS technique (MD −2.1 days, 95% CI −2.7 to −1.4, p < 0.01). There was no significant difference with respect to leg visual analog scale scores, Oswestry Disability Index scores, blood loss, surgical time, and complications, and there were not any significant quality or bias concerns. CONCLUSIONS Both endoscopic and MIS techniques are safe and effective methods for treating patients with symptomatic lumbar stenosis. Patients who undergo endoscopic surgery seem to report less postoperative low-back pain and significantly reduced hospital stay with a trend toward less perioperative blood loss. Future large prospective randomized trials are needed to confirm the findings in this study.
6
Joergensen, Maren Poulsgaard Poulsgaard, Andreas Kiesbye Oevlisen, Lasse Hjort Jakobsen, Tarec Christoffer Christoffer El-Galaly, and Marianne Tang Severinsen. "Incidence and Prevalence of Mastocytosis in Adults: A Danish Nationwide Register Study." Blood 142, Supplement 1 (2023): 6339. http://dx.doi.org/10.1182/blood-2023-188451.
Full textAbstract:
Introduction: Mastocytosis is a heterogeneous chronic disease caused by a mutation in the cKIT gene that allows for uncontrolled proliferation, accumulation and activation of abnormal mast cells. Mastocytosis is divided into cutaneous mastocytosis (CM) and systemic mastocytosis (SM) in which abnormal mast cells are found in various tissues of the body. SM is further divided into the following five subtypes related to disease severity: indolent systemic mastocytosis (ISM), smoldering systemic mastocytosis (SSM), aggressive systemic mastocytosis (ASM), systemic mastocytosis with an associated hematologic neoplasm (SM-AHN) and mast cell leukemia (MCL). Mastocytosis is considered a rare disease with an incidence and prevalence previously found to be 0,89 per 100.000 and 9,59 per 100.000, respectively; however, recent improvements related to diagnostic methods could have led to an increased incidence and prevalence. Therefore, updated data is needed. Methods: This study is a retrospective nationwide register study including all adult (≥18 years) patients with mastocytosis in Denmark diagnosed between January 1 st 1997 and December 31 st 2021. The study was conducted using the Danish Civil Registration System to merge data from the National Patient Register (NPR), the Danish Pathology Register (DPR) and the Danish Cancer Register (DCR). The National Patient Register contain information on all inpatient and outpatient contacts and is considered complete as of 1995-2018. The Danish Pathology Register contain information about all biopsies and pathologic examinations in Denmark and is considered complete as of 1997 to 2021. The Danish Cancer Register contain information on all incidences of cancer in Denmark and is considered complete as of 1987-2021. Year of diagnosis was considered as the earliest date across all registers and patients were categorized as most severe subtype of mastocytosis. The registers did not allow for a categorization of SSM and therefore indolent mastocytosis were all categorized as ISM. Patients without a positive extracutaneous biopsy and who have never been examined with a bone marrow biopsy were classified as mastocytosis in the skin (MIS). Results: These data are the preliminary results of this study. 1627 patient were included (female 924, 56,8%). Mastocytosis in the skin was the most prevalent type of mastocytosis (774, 47,57%), followed by ISM (441, 27,11%), CM (222, 13,64%) and SM-AHN (179, 11%), More than 80% of patients with ASM had another hematologic neoplasm and were categorized as SM-AHN. Few patients were classified as ASM (4, 0,25%) and MCL (7, 0,43%). A positive bone marrow biopsy was found among 601 (36,94%) of the patients; however, 774 (47,57%) patients with mastocytosis were not examined with a bone marrow biopsy. The incidence rate of mastocytosis (all subtypes) was lowest in 2003 with an incidence of 0,74 per 100.000. Hereafter, the incidence increased until reaching the highest level in 2018 with an incidence of 2,77 per 100.000 (figure 1). The 25-year limited-duration prevalence as of 1 st January 2022 was 28,44 per 100.000. Conclusion: This nationwide register study provides updated data on the prevalence and incidence of mastocytosis in Denmark. The incidence rate was found to have an increasing trend until 2018 when it reached the highest value of 2,77 per 100.000. The prevalence was found to be 28,44 and thereby higher than previous studies have found. However, the true prevalence is potentially higher as the data for the years 2019-2021 solely relies on the pathology register. This is preliminary data, and the results will be updated when the NPR is complete for these years.Further analysis will be conducted using the Register of Laboratory Results for Research to evaluate blood tests regarding tryptase levels as well as to provide further information regarding KIT mutational status.
7
Hatem, Marie, Aboubakary Sanou, Bernard Millette, Ségolène de Rouffignac, and Majda Sebbani. "La responsabilité sociale en santé : référents conceptuels, valeurs et suggestions pour l’apprentissage. Une revue méthodique et systématique de la littérature." Pédagogie Médicale 23, no. 1 (2022): 27–48. http://dx.doi.org/10.1051/pmed/2022002.
Full textAbstract:
Contexte et problématique : Certains auteurs datent les références historiques de la responsabilité sociale en santé (RSS) d’aussi loin que le serment hippocratique. De la multitude de termes et définitions, la prédominance de certaines références a mis en exergue ce qu’est cette notion en termes de concepts, valeurs et compétences. Objectif : Le but du présent article était de contribuer à l’élaboration, à partir des différentes sources recensées, d’une définition et d’un contenu de la RSS, à utiliser pour la formation du personnel de santé en partant de la question : qu’est-ce qu’un clinicien, un chercheur, un gestionnaire socialement responsable en santé ? Méthodes : Une revue méthodique et systématique de la littérature a été effectuée. Les sources de données bibliographiques en ligne explorées couvrent : Medline, Embase, EBM Reviews et Cochrane Library et Cochrane Database of Systematic Reviews, ACP Journal Club, Database of Abstracts of Reviews of Effects, Cochrane Clinical Answers, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register, Health Technology Assessment, NHS Economic Evaluation Database, Ovid Medline ®. Résultats : Parmi 1154 documents identifiés, 127 ont été retenus. La RSS se réfère prioritairement à la prise en compte des besoins des communautés. La documentation de l’OMS a servi de référence à 45 % des définitions et 40 % des valeurs. Seuls deux écrits évoquaient la durabilité environnementale. Discussion et conclusion : Une notion de RSS à promouvoir intègrerait les engagements et concepts développés dans le domaine de la santé, les valeurs humaines, les compétences professionnelles, les questions de comptes à rendre en matière économique et la durabilité.
8
Jones, Nick. "Far from Houdini: The ‘Magic’ of the VFX Breakdown." Animation 18, no. 1 (2023): 42–58. http://dx.doi.org/10.1177/17468477231155541.
Full textAbstract:
VFX (visual effects) breakdowns are short ancillary videos that advertise the digital animation work undertaken by a VFX company for a particular film or television programme. Claiming to take viewers ‘behind the magic’ of VFX, breakdowns disassemble a wide variety of shots and sequences, and point to the extensive use of computer-generated imagery in contemporary blockbuster cinema. But, as much as breakdowns reveal some illusions, they conjure others. Breakdowns operate in a register of speed, fluidity and efficacy, showing neither the many people nor the extensive periods of time that it takes to painstakingly generate all these VFX. In this article, the author reveals how the omission of labour and duration in VFX breakdowns both reflects and contributes to a broader (mis)understanding of digital effects as immaterial, instantaneous and magical. His case study is Spider-Man: Far From Home (2019), a film that links VFX with magic, evokes the breakdown in some of its spectacular visuals, and even outright villainizes those effects artists who seek fair recognition for their work.
9
Low, Audrey S. L., Deborah P. M. Symmons, Mark Lunt, et al. "Relationship between exposure to tumour necrosis factor inhibitor therapy and incidence and severity of myocardial infarction in patients with rheumatoid arthritis." Annals of the Rheumatic Diseases 76, no. 4 (2017): 654–60. http://dx.doi.org/10.1136/annrheumdis-2016-209784.
Full textAbstract:
ObjectivesPatients with rheumatoid arthritis (RA) are at increased risk of myocardial infarction (MI) compared with subjects without RA, with the increased risk driven potentially by inflammation. Tumour necrosis factor inhibitors (TNFi) may modulate the risk and severity of MI. We compared the risk and severity of MI in patients treated with TNFi with that in those receiving synthetic disease-modifying antirheumatic drugs (sDMARDs).MethodsThis analysis included patients with RA recruited from 2001 to 2009 to the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis starting TNFi (etanercept/infliximab/adalimumab) and a biologic-naïve comparator cohort receiving sDMARD. All patients were followed via physician and patient questionnaires and national death register linkage. Additionally, all patients were linked to the Myocardial Ischaemia National Audit Project, a national registry of hospitalisations for MI. Patients were censored at first verified MI, death, 90 days following TNFi discontinuation, last physician follow-up or 20 April 2010, whichever came first. The risk of first MI was compared between cohorts using COX regression, adjusted with propensity score deciles (PD). MI phenotype and severity were compared using descriptive statistics. 6-month mortality post MI was compared using logistic regression.Results252 verified first MIs were analysed: 58 in 3058 patients receiving sDMARD and 194 in 11 200 patients receiving TNFi (median follow-up per person 3.5 years and 5.3 years, respectively). The PD-adjusted HR of MI in TNFi referent to sDMARD was 0.61 (95% CI 0.41 to 0.89). No statistically significant differences in MI severity or mortality were observed between treatment groups.ConclusionsPatients with RA receiving TNFi had a decreased risk of MI compared with patients with RA receiving sDMARD therapy over the medium term. This might be attributed to a direct action of TNFi on the atherosclerotic process or better overall disease control.
10
Pervyshin, Nikolai A., Inna V. Lebedeva, and Elena A. Lebedeva. "Analysis of providing medical care to patients with diabetes in foreign countries." Aspirantskiy Vestnik Povolzhiya 20, no. 1-2 (2020): 28–36. http://dx.doi.org/10.17816/2072-2354.2020.20.1.28-36.
Full textAbstract:
The authors of the article analyzed the publications devoted to the prospects of medical care to diabetic patients abroad. The main attention is paid to gross observational pharmacoeconomical studies as the most effective tool for planning and organization of specialized medical care for patients with diabetes. There is a tendency to increase the role of outpatient care for sufferers, as well as to introduce the elements of standardization, modern information and communication technologies into clinical practice. The challenges of implementation of medical information systems (MIS) to manage the quality of medical care in clinical practice are also pointed out. Proper evaluation of quality parameters is impossible without a complex process of collecting primary medical data with the use of modern computer technology. To ensure the reliability and relevance of information, it is desirable that it is collected and entered into the database by the attending physician directly at the outpatient reception hours. AWPE DM (automated workplace of an endocrinologist for outpatient admission of patients with diabetes mellitus) is a computer program designed to collect medical data of outpatients without additional working time expenditures, followed by a printout of the formalized protocol. Its application in everyday practice allows to solve the local problem of formalization and informational support of primary care to diabetic patients, to systematize the processes of collecting primary medical information. In the future, data provided by AWPE DM can be exported to the Federal Register of Diabetes Mellitus (FRDM) in order to update its database.
11
Wilander, Henrik, Christos Pagonis, Dimitrios Venetsanos, et al. "Nationwide observational study of incidence, management and outcome of spontaneous coronary artery dissection: a report from the Swedish Coronary Angiography and Angioplasty register." BMJ Open 12, no. 6 (2022): e060949. http://dx.doi.org/10.1136/bmjopen-2022-060949.
Full textAbstract:
ObjectivesThe aim of this study was to conduct a nationwide all comer description of incidence, contemporary management and outcome in Swedish spontaneous coronary artery dissection (SCAD) patients. The incidence of SCAD as well as the management and outcome of these patients is not well described.DesignA nationwide observational study.Participants and settingAll patients with SCAD registered in the Swedish Coronary Angiography and Angioplasty Register from 2015 to 2017 were included. The index angiographies of patients with registered SCAD were re-evaluated at each centre to confirm the diagnosis. Patients with non-SCAD myocardial infarction (MI) (n=32 601) were used for comparison.Outcome measuresOutcomes included all-cause mortality, reinfarction or acute coronary reangiography.ResultsThis study found 147 SCAD patients, rendering an incidence of 0.74 per 100 000 per year and a prevalence of 0.43% of all MIs. The average age was 52.9 years, 75.5% were women and 47.6% presented with ST-segment elevation MI. Median follow-up time for major adverse cardiac event was 17.3 months. Percutaneous coronary intervention was attempted in 40.1% of SCAD patients and 30.6% received stent. The use of antithrombotic agents was similar between the groups and there was no difference regarding outcomes, 10.9% vs 13.4%, p=0.75. Mortality was lower in SCAD patients, 2.7% vs 8.0%, p=0.03, whereas SCAD patients more often underwent acute reangiography, 9.5% vs 4.6%, p<0.01.ConclusionIn this nationwide, all comer Swedish study, the overall incidence of SCAD was low, including 25% men which is more and in contrast to previous studies. Compared with non-SCAD MI, SCAD patients were younger, with lower cardiovascular risk burden, yet suffered substantial mortality and morbidity and more frequently underwent acute coronary reangiography.
12
Kallasmaa, Marja, and Fred Puss. "Üks laenuline perekonnanime tüüp: nimed lõpuga -mees." Eesti ja soome-ugri keeleteaduse ajakiri. Journal of Estonian and Finno-Ugric Linguistics 11, no. 1 (2020): 23–42. http://dx.doi.org/10.12697/jeful.2020.11.1.02.
Full textAbstract:
Kirjutises esitletakse Eesti perekonnanimede tüüpi, kus nime lõpuosiseks on -mees. Perekonnanimede panekul 1822–1835 on nimesid lõpuga -mees (-mes) pandud rohkem kui 140 mõisas. Paljud neist on hääbunud, samas on seda tüüpi perekonnanimesid pandud/võetud ka XX sajandil: 1921–1922 Petserimaal ja Narvatagusel ning 1935–1940 nimede eestistamisel. Kirjutises on ära toodud kõik 63 mees-lõpulist perekonnanime, mis esinesid rahvastikuregistris aastal 2017, nimekandjate hulk sel aastal, nimede päritolu ja tekkekoht, enamasti mõisa täpsusega. Nenditakse, et nimetüüp lõpuga -mees on laen saksa keelest (tõlgitud on saksa perekonnanimede formant -mann ’mees, inimene’), ehkki vastavaid eeskujuks olevaid liitsõnu esineb ka eesti keeles (näiteks aumees, jahimees, kälimees, maamees, põllumees, sannamees, talumees, nimepanemise ajal arvatavasti juba ka laenuline kaupmees). Saksa keelest on enamasti siiski laenatud nii perekonnanimede struktuuritüüp kui ka sageli nimeosade leksika (mugand, laen või otsetõlge eesti keelde). Vaid iga kümnenda nime puhul võiks väita, et aluseks on eestikeelne liitsõna. Huvitaval kombel järgib mees-lõpuline perekonnanimetüüp levikuala, mis on kindlaks tehtud paljude murdenähtuste puhul.
 Abstract. Marja Kallasmaa and Fred Puss: A borrowed name type: surnames ending with ‑mees ‘man’. In the Population Register in 2017, there were 63 surnames ending with -mees ‘man’. The article presents the etymology of all these names. The Estonian surname type ending -mees has mostly been borrowed from German surnames with the name formant -mann. Estonian peasants received their surnames in the 19th century (about 31,000 surnames in 1822–1835, of those around 100 ending with -mees). Among those, there were around 5,020 occasions of surnames (around 2,000 different names) ending with -man(n), mostly in North Estonia. In 1935–1940, the peak of the Estonianization of surnames took place and 22 names ending with -mees were added. 1. Most of surnames ending with -mees are translation loans as Jõemees (Bachmann), Majamees (Hausmann), Metsmees (Waldmann), Mäemees (Bergmann), Nõmmemees (Heidemann), etc. In one surname, a partial translation of the first part has been found: Piirimees (Altegrenzmann). 2. Surnames with adapted first part: Valdmees (Waldmann), Kunstimees (Kunstmann). 3. There are different first parts of surnames in the islands of Hiiumaa and Saaremaa: in Hiiumaa, the first parts are toponyms, in Saaremaa, mostly adjectives. 4. Some surnames present the dialectal form versus standard language form: Mõtsmees and Metsmees (dialectal mõts, standard mets ‘forest’), Tepomees and Teppomees (standard male name Tepo, in the coastal dialect Teppo, same in the old spelling), Sannamees (standard saunamees ‘smallholder’). The surname written in 1835 – Maelzemees – has given three different present-day spellings: Mäeltsemees, Mältsamees and Määltsemees. 5. German influence is both structural and lexical (translation, adaptation, word selection). 6. Only around one tenth of the names come from Estonian compound words.
13
Vamshidhar, I. S., S. S. Sabitha Rani, Medala Kalpana, et al. "Impact of COVID-19 on thyroid gland functions with reference to Graves’ disease: A systematic review." Journal of Family Medicine and Primary Care 12, no. 9 (2023): 1784–89. http://dx.doi.org/10.4103/jfmpc.jfmpc_2246_22.
Full textAbstract:
ABSTRACT Coronavirus disease 2019 (COVID-19) is caused due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Both immediate and long-term adverse effects arise out of this disease’s aftermath. It involves various organs, which include endocrine glands, nervous system, musculoskeletal system, and other organs. The long-term outcomes of the SARS-CoV-2 infection are influenced by preexisting comorbidities. Genetic, environmental, and immunological factors contribute to the development of various autoimmune diseases, which include Graves’ disease (GD). The growing mystery surrounding this virus is exacerbated by auto-inflammatory diseases, such as pediatric inflammatory multisystemic syndrome (PIMS) or multisystem inflammatory syndrome in children (MIS-C), which raises concerns about the nature of the virus’ connection to the autoimmune and auto-inflammatory sequelae. There is a need to understand the underlying mechanisms of developing GD in post-COVID-19 patients. There are limited data regarding the pathogenesis involved in post-COVID-19 GD. Our goal was to understand the various mechanisms involved in post-COVID-19 GD among patients with confirmed COVID-19 infection. According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for 2020, a literature search of medical databases (PubMed, Cochrane Central Register of Controlled Trials, and Scopus) from February 2021 to February 2022 was performed by five authors. The keywords used were “Post COVID-19,” “Grave’s disease,” “Cytokine storm,” “Autoimmunity,” and “Molecular mimicry.” This review revealed three underlying mechanisms that resulted in post-COVID GD, which included cytokine storm, molecular mimicry, ACE2 receptor concentration, and cell-mediated immunity. The full spectrum of the effects of COVID-19 needs to be researched.
14
Kankya, Clovice, James Muleme, Lydia Nabawanuka Namakula, George Seruwagi, Christine Mbabazi Mpyangu, and Lesley Rose Ninsiima. "Gender perspectives on zoonotic disease epidemiology; A strength weakness opportunities threats analysis in Bundibugyo district, Uganda." PLOS One 20, no. 5 (2025): e0324442. https://doi.org/10.1371/journal.pone.0324442.
Full textAbstract:
Background Gender mainstreaming in zoonotic disease prevention and control is paramount to produce sustainable solutions as well as keeping communities at the human-animal-environment interface safe and healthy. It is important to note that zoonoses register high mortality rates globally once they occur and they are highly transmissible. Hence this study aimed to explore the gender perspectives on zoonotic disease epidemiology using a (strength, weakness, opportunities and threats) SWOT analysis in Bundibugyo district, Uganda. Methods This study employed a descriptive participatory approach, utilizing data gathered sequentially from 12 Key informant interviews, 4 In-depth interviews and 4 Focus group discussions methods in Bundibugyo district. Interviews used interdisciplinary groups systematically using a SWOT analysis. The research methodology employed an interpretative phenomenological analysis (IPA) approach allowing participants to articulate their perspectives in their own words. Data analysis was done using both inductive and deductive thematically using NVIVO 12 pro, facilitating the development of codes, sub-themes, and themes. Results The results of this study prioritized key zoonotic diseases within the district that affect community health. The key themes from these results a) Threats increasing risk of zoonotic spillover, b) Community weaknesses increasing zoonotic diseases occurrence, c) Community strength for zoonotic disease management, prevention and control, d) Opportunities for communities in management of zoonotic diseases. The study emphasizes that political instability, land migration, food insecurity, cultural hunting practices, and climate change act to increase the risk of zoonotic diseases. Complications arise from the mis-identification of diseases due to similar symptoms, and a lack of community education about these diseases. The risk of exposure is influenced by gender roles, with men, who generally interact more with animals, at higher risk. Conversely, women, due to their roles in caring for the sick and involvement in child immunization, are at risk but also play a crucial role in disease control. Despite these challenges, there are opportunities for disease management and prevention such as leveraging experienced health workers for disease identification and education, utilizing local communication channels, engaging opinion leaders for effective risk communication, and providing regular training for health workers could address these issues. However, limited funding hinders the execution of recommended strategies such as regular surveillance, tracing of suspected cases, and health register reviews. Conclusion This study emphasizes the necessity of gender-sensitive approaches in understanding and mitigating zoonotic diseases, advocating for strategies that recognize socio-cultural factors, promote health education, and tailor interventions to provide comprehensive care and protection for all, irrespective of gender.
15
Nugraheni, Aninditya Sri, and Sugiharto Sugiharto. "EDUCATION PSYCHOLOGICAL UNDERSTANDING ON MADRASAH IBTIDAIYAH EDUCATORS IN BANTUL." Sunan Kalijaga International Journal on Islamic Educational Research 1, no. 1 (2018): 123–35. http://dx.doi.org/10.14421/skijier.2017.2017.11-08.
Full textAbstract:
Education world cannot be separated from psychology of education. Scholarly relevant to psychology of education is crucial to be understood by each educator. However, seeing the existing phenomena, there are many educators who lack of comprehension on it. The researcher finds discrepancy between the educator’s action and the existing psychological theory. Learners deserve and have to obtain skill and science which are appropriate with their age. Therefore, the researcher conduct a research towards educators on the understanding in psychology of education concerning reading and writing skill for learners in Primary School/MI age. Based on the research conducted by the researcher, data which is obtained by four private MIs by using interview towards 25 educators who are scholars, it can be drawn a conclusion that most of them have not comprehended the skill which is appropriate with Primary School/MI learners of 1st grade. For instance, they agree to carry out reading and writing test as the requirement to register the Primary School/MI which is 70%. It is discussed in Act Number 20 Year 2003 on National Education System. On Paragraph 3 of Article 69, it is mentioned that Learners Admissions of 1st grade of Primary School/MI or other equal school is not based on the result of reading, writing, calculating and other types of test. Furthermore, concerning learners’ readng and writting skill of certain age, 75% of them answer in the end of childhood period, 20% of them answer in the beginning of 1st grade and the others, which is 5% of them answer in the beginning of 1st grade or ahead of the second grade. 5% of them asnwer on the period between the first and second grade. It indicates the need of government’s socialization associated with psychology of education towards educators.
16
Milenković, Aleksandar, Dragan Janković, Anđelija Đorđević, Aleksandar Spasić, and Petar Rajković. "REALIZATION OF DISTRIBUTED MEDICAL DATA REPOSITORY IN AN ENVIRONMENT WITH HETEROGENOUS MIS." Facta Universitatis, Series: Automatic Control and Robotics 20, no. 3 (2021): 135. http://dx.doi.org/10.22190/fuacr210930011m.
Full textAbstract:
The introduction of centralized registers of medical data after a long time from the implementation of medical information systems and their long-term daily operation is a very challenging and demanding process. In this paper, three ways for the realization of centralized repositories of medical data are considered, and on that occasion, the advantages and limitations of these solutions are emphasized. Due to the heterogeneity of medical information systems in terms of technologies used and implementation, the construction of a distributed centralized national register of medical data emerges as a good solution. A proposal of architecture for the realization of the distributed central republic register of medical data is given. As an example of the proposed solution, the realized collaboration of the central republic radiological information system and its implementation with the medical information system MEDIS.NET is presented.
17
Tian, Z., L. Kearsley-Fleet, K. Lauper, et al. "AB0405 NO DIFFERENCE IN RISK OF MYOCARDIAL INFARCTION AMONG PATIENTS RECEIVING EITHER IL6 OR TNF INHIBITORS FOR RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1387.2–1388. http://dx.doi.org/10.1136/annrheumdis-2023-eular.782.
Full textAbstract:
BackgroundInterleukin 6 inhibitors (IL-6i) can increase LDL cholesterol levels, which raises concerns about the risk of myocardial infarction (MI) in patients with rheumatoid arthritis (RA) receiving this therapy.ObjectivesThis study aims to compare the risk of MI between people with RA in the UK clinical setting receiving IL-6i or tumour necrosis factor inhibitors (TNFi) overall or by line of therapy (LoT).MethodsPatients with RA registered between 01/10/2001 and 30/05/2022 with BSRBR-RA starting IL-6i or TNFi treatments were included. Occurrence of MI was identified from clinical follow-up forms and through cause of death reported by the national UK death register. Only those MIs occurring whilst patient was actively receiving drug were included. The risk of MI in patients receiving IL6i compared to TNFi was compared using Cox regression, adjusted for baseline co-variates using propensity scores (PS, see Table 1). Follow-up commenced at the start of the drug of interest and patients were censored at occurrence of MI, death, discontinuation of therapy or last follow-up visit, whichever came first. Multiple imputation was used for missing data. To account for known differences in LoT use of TNFi and IL6i (with IL6i more likely as a later line bDMARD), overall analyses adjusted for LoT in PS and secondary analyses by LoT were conducted. Direct switches between originator to biosimilars were considered the same treatment.ResultsA total of 30,022 IL6i or TNFi LoTs in 20,898 patients were included (3,278 IL-6i; 26,744 TNFi), representing 119,797 person-years of exposure. Compared to patients receiving TNFi, patients starting IL-6i treatment were older, had longer disease duration, less likely to use methotrexate and steroids, and had more comorbidities. During follow-up, 409 MIs occurred, 30 on IL-6i and 379 on TNFi. After PS adjustment, the risk of MI was not significantly different between the two treatment overall (HR 0.87, 95% CI 0.56-1.37) or when stratified by LoT (Table 1).ConclusionThis study could not identify any difference in risk of MI between IL-6i and TNFi treatment after patient characteristics and LoT were considered.TableMI in RA patients treated with IL-6i or TNFinPerson-yearsEventsIR per 1000 person year (95% CI)Crude HRPS Adjusted HR (95% CI)(95% CI)All lines of therapy TNFi26,744110,9813793.41 (3.09, 3.78)RefRef IL-6i3,2788,816303.40 (2.38, 4.87)0.93 (0.64, 1.35)0.87 (0.56, 1.37)First line TNFi16,38371,6542443.41 (3.00, 3.86)RefRef IL-6i3521,05743.78 (1.42, 10.08)1.04 (0.39, 2.80)1.26 (0.46, 3.41)Second line TNFi766631,4731023.24 (2.67, 3.94)RefRef IL-6i7491,89942.11 (0.79, 5.61)0.59 (0.22, 1.61)0.64 (0.23, 1.76)Third line TNFi1,7185,652264.60 (3.13, 6.76)RefRef IL-6i1,0592,838113.88 (2.15, 7.00)0.79 (0.38, 1.60)0.80 (0.37, 1.70)Fourth line and above TNFi9772,20373.18 (1.51, 6.67)RefRef IL-6i1,1183,023113.64 (2.92, 6.57)1.16 (0.45, 3.01)0.90 (0.33, 2.47)*Baseline variables used for propensity score adjustment: age, gender, time between BSRBR-RA registration and drug start, DAS28, disease duration, RF status, smoking history, BMI, current methotrexate, total number of prior csDMARDs, line of therapy (only in analyses of all LoTs), prior use of TNFi (not in analyses of first LoT only), prior use of IL6i (not in analyses of first or second LoT only), current use of steroids, ever use of antiplatelet or anticoagulant drugs; history of: hypertension, dyslipidaemia, diabetes, lung disease, renal disease, depression, cancer, venous thromboembolism, ischemic heart disease (myocardial infarction and angina), strokeReference[1]Atzeni, F., Rodríguez-Carrio, J., Popa, C. D., Nurmohamed, M. T., Szűcs, G. & Szekanecz, Z. (2021). ‘Cardiovascular effects of approved drugs for rheumatoid arthritis’, Nat Rev Rheumatol.Acknowledgements:NIL.Disclosure of InterestsZixing Tian: None declared, Lianne Kearsley-Fleet: None declared, Kim Lauper: None declared, Sally Haughton: None declared, Kath Watson: None declared, Mark Lunt: None declared, John Mclaughlin: None declared, Arpana Verma: None declared, Kimme Hyrich Consultant of: Honoraria from Abbvie, Grant/research support from: Grant income from Pfizer and BMS.
18
Goutsos, Dionysis. "Translation in Bilingual Lexicography." Babel. Revue internationale de la traduction / International Journal of Translation 45, no. 2 (1999): 107–26. http://dx.doi.org/10.1075/babel.45.2.02gou.
Full textAbstract:
Abstract Greek bilingual dictionaries have long been marked by lack of naturalness and inadequate semantic and stylistic discrimination between the various equivalents suggested in translation. Although this is a general problem of bilingual dictionaries, which necessarily deal with decontextualized instances of language in the construction of the lemma, translationese is common in English-Greek dictionaries as a result of the idiosyncratic history of Greek applied linguistic practice. The paper discusses issues of translation equivalence that came into view in the editing of the new Collins English-Greek Dictionary (1997). Specific problems relating to the translation from English to Greek are pointed out, with reference to the areas of lexical, grammatical and discourse equivalence. In particular, the occurrence of 'false friends' and register couplets, the categories of definiteness, countability and verb aspect and the varying Theme-Rheme structures constitute points of divergence between the two languages. The word-for-word translation of these linguistic aspects is mainly accountable for the lack of naturalness. Dictionary editing involves a multitude of detailed decisions along these parameters, which shape the lemmas and influence the quality of the final text. The help from both English and Greek corpora has been indispensable at defining the parameters of naturalness for each lemma and at solving problems specific to Greek bilingual lexicography. Résumé Les dictionnaires bilingues grecs ont été longtemps marqués par un manque de naturel, par une discrimination sémantique et stylistique inadéquate entre les différentes équivalences suggérées dans la traduction. Bien qu'il s'agisse d'un problème général propre aux dictionnaires bilingues, qui, nécessairement se fondent sur des exemples hors de leur contexte linguistique lors de la construction du vocable, des traductions trop influencées par la langue de sortie sont communes dans les dictionnaires anglais-grec à la suite de l'histoire idiosyncratique de la pratique de la linguistique appliquée grecque. L'article se penche sur les problèmes de l'équivalence traductionelle lors de la rédaction du nouveau dictionnaire anglais-grec (Collins - 1997). Des problèmes spécifiques relatifs à la traduction de la langue anglaise à la langue grecque sont mis en évidence relativement aux domaines de l'équivalence lexicologique, grammaticale et du discours. Plus spécialement, l'émergence de "faux amis" et de couples dans le registre, les catégories de précision, la comptabilité des substantifs et l'aspect des verbes ainsi que les structures variables thème-rhème constituent des points de divergence entre les deux langues. La traduction mot-à-mot de ces aspects linguistiques est surtout due au manque de naturel. La rédaction de dictionnaires implique une multitude de décisions détaillés suivant ces paramètres, qui régissent les vocables et influencent la qualité du texte final. L'aide des corpus anglais et grecs a été indispensable lors de la définition des paramètres du naturel pour chaque vocable et lors de la solution des problèmes spécifiques à la lexicographie bilingue grecque.
19
Khramtsova, Natalia Anatolyevna. "CARDIOLOGICAL SERVICE OF THE IRKUTSK REGION - RESULTS OF 2022 AND DIRECTIONS OF DEVELOPMENT." Baikal Medical Journal 2, no. 3 (2023): 13–15. http://dx.doi.org/10.57256/2949-0715-2023-3-13-15.
Full textAbstract:
At the end of 2022, there were several positive trends in the performance of the cardiology service. Thus, mortality from circulatory system diseases (CVD) in the Irkutsk region, according to Rosstat, decreased by 4.3% compared to 2021 and amounted to 676.3 per 100,000 population. The mortality rate from MI also decreased and reached 52.9 per 100,000 population. According to the results of the year, a decrease in the total number of deaths from myocardial infarction by 145 people was noted. The proportion of hospitalizations in specialized departments of PSO and RSC increased by 6.2%, which led to a significant decrease in the number of patients who died from myocardial infarction (MI) outside the specialized departments (-54.3%). The total number of patients with acute coronary syndrome (ACS) hospitalized in specialized departments (RCC and PSO) out of all patients with ACS increased by 13.9%. The number of patients with ST-elevation ACS who underwent reperfusion therapy, both primary PCI up to 52.6%, and after thrombolytic therapy (TLT) increased. The number of X-ray endovascular interventions on the coronary arteries for medical purposes increased by 35%, on an accrual basis by the end of the year, the figure was 3952 manipulations. At the end of the year, there was a decrease in mortality from MI by 12.7%, and the figure was 10.3%, which is one of the lowest values in the Siberian Federal District. A decrease in hospital mortality from MI was recorded both in the medical organizations of the region by 2.4%, and in PSO and RSC - by 3.3%. The coverage of dispensary observation and preferential drug provision for patients after MI, coronary artery bypass grafting, radiofrequency ablation, coronary artery stenting and stroke was 92.2%. A remote ECG system for planned patients has been introduced in the region (more than 20,000 consultations have been carried out). The format of round-the-clock reception and interpretation of ECG in patients with ACS is preserved to determine the tactics of management and routing of patients. These possibilities are necessary for making decisions on timely thrombolytic therapy at the stages of evacuation of a patient with ACS and ST segment elevation. Of the problematic aspects, there is a continuing increase in mortality from coronary heart disease by 8.1% and an increase in the number of deaths from coronary artery disease outside medical organizations. The problem of increasing mortality from chronic cardiovascular diseases is due to defects in medical examination and dispensary observation at the outpatient stage. Shortcomings in the work of primary care resulted in high mortality from coronary artery disease, myocardial infarction, CHF at home, insufficient coverage of patients with CVD by dispensary observation and poor quality of dispensary appointments. Of the main priority areas in the work of the cardiological service for the next year, the following should be highlighted: control over the implementation of clinical guidelines (recurring training and testing of doctors, paramedical personnel according to clinical recommendations, multi-level examination of the quality of medical care, the introduction of medical decision support services into practice); optimizing the routing of patients with ACS and other cardiovascular diseases to the specialized departments of the region (organization of interaction between the emergency medical service, the center for disaster medicine and medical organizations in the region, eliminating time losses during the evacuation of patients with ACS, daily monitoring of hospitalizations of the region's ACS); increase in the number of pre-hospital thrombolysis in patients with ACS with ST-segment elevation (training of paramedics and doctors of mobile ambulance teams in ECG interpretation skills and first aid skills in ACS (simulation-training cycles), the widespread introduction of a “second opinion” on ECG, the presence of thrombolytics in packing SMP, daily monitoring of prehospital thrombolysis by heads of medical organizations); development of remote telemedicine technologies; control over preferential drug provision (organization of succession between the hospital and the clinic, ensuring timely (within 72 hours) placement for dispensary observation of patients of the category of Order No. 639n, control of adherence to the prescribed therapy, exclusion of unreasonable de-escalation of doses, cancellation / replacement of drugs. at the outpatient stage, maintaining a register of DLO); dispensary observation (DN) of patients with CVD (registration in MIS of certain groups of patients with CVD for the possibility of automatic generation of lists for DN, proactive invitation to DN of patients with CVD according to a pre-formed list for examination as soon as possible). Thus, the main areas of work for primary care physicians are focused on quantitative and qualitative indicators of medical examination and dispensary observation, with the creation in each polyclinic of a system for monitoring subsidized drug provision and a system for registering high-risk patients. For the ambulance stage, strict adherence to the routing and rapid delivery of patients with ACS is required, with pre-hospital thrombolysis, training of doctors / paramedics in emergency cardiology and the introduction of a remote ECG system. At the inpatient stage of medical care, continue work to improve the profile of treatment of CVD patients by minimizing hospitalizations in therapeutic departments, for this purpose, the creation of interdistrict cardiology departments, the introduction of clinical recommendations on cardiology into wide practice and control over the continuity of care with the outpatient link.
20
Abhijeet, Gaikwad, Mulla Nilofar, and Dhane |. Moreshwar Tendulkar |. Tushar Jadhav ishal. "Smart Blood Finder." International Journal of Trend in Scientific Research and Development 2, no. 1 (2017): 1027–32. https://doi.org/10.31142/ijtsrd7183.
Full textAbstract:
In case of emergency needs the most important lives saver necessity is Blood. Blood Banks are the main providers of blood who receives blood from various donors, monitors the blood groups database and in case of emergencies makes the available to the hospital whenever needed. The major problem faced by the main blood providers and the need is the availability of donor at right time. We hereby took a step forward to build a system to create a network of people who can help each other in need. We propose an application where the Blood banks can timely update the Blood Stock availability and donor and register themselves to donor and user can find blood availability nearby him her. In the urgent time of a blood requirement, user can quickly check for blood banks, hospitals or donor as per requirement matching a particular or related blood group and reach out to them through the App. Application tends to provide list of blood banks in user area. A large number of blood donors are attracted using an Android application. Since almost everyone carries a mobile phone with him, it ensures instant location tracking and communication. Registered user, who is willing to donate blood can pledge him her to donate and will be able to access the service. In this application we are using the GPS technology that will be used to trace the way to the blood bank. The user will get the route to reach the desired location and he she won't have to ask manually, therefore time can be saved. Abhijeet Gaikwad | Nilofar Mulla | Tejashri Wagaj | Raviraj Ingale | Prof. Brijendra Gupta | Prof. Kamal Reddy "Smart Blood Finder" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-1 , December 2017, URL: https://www.ijtsrd.com/papers/ijtsrd7183.pdf
21
Mundt, Torsten, Friedhelm Heinemann, Janine Müller, Christian Schwahn, and Ahmad Al Jaghsi. "Survival and stability of strategic mini-implants with immediate or delayed loading under removable partial dentures: a 3-year randomized controlled clinical trial." Clinical Oral Investigations, December 6, 2022. http://dx.doi.org/10.1007/s00784-022-04805-2.
Full textAbstract:
Abstract Objectives Stability values of mini-implants (MIs) are ambiguous. Survival data for MIs as supplementary abutments in reduced dentitions are not available. The aim of this explorative research was to estimate the 3-year stability and survival of strategic MIs after immediate and delayed loading by existing removable partial dentures (RPDs). Material and methods In a university and three dental practices, patients with unfavorable tooth distributions received supplementary MIs with diameters of 1.8, 2.1, and 2.4 mm. The participants were randomly allocated to group A (if the insertion torque ≥ 35 Ncm: immediate loading by housings; otherwise, immediate loading by RPD soft relining was performed) or delayed loading group B. Periotest values (PTVs) and resonance frequency analysis (RFA) values were longitudinally compared using mixed models. Results A total of 112 maxillary and 120 mandibular MIs were placed under 79 RPDs (31 maxillae). The 1st and 3rd quartile of the PTVs ranged between 1.7 and 7.8, and the RFA values ranged between 30 and 46 with nonrelevant group differences. The 3-year survival rates were 92% in group A versus 95% in group B and 99% in the mandible (one failure) versus 87% in the maxilla (eleven failures among four participants). Conclusions Within the limitations of explorative analyses, there were no relevant differences between immediate and delayed loading regarding survival or stability of strategic MIs. Clinical relevance The stability values for MIs are lower than for conventional implants. The MI failure rate in the maxilla is higher than in the mandible with cluster failure participants. Clinical trial registration German Clinical Trials Register (Deutsches Register Klinischer Studien, DRKS-ID: DRKS00007589, www.germanctr.de), January 15, 2015.
22
Dehlaghi Jadid, Kaveh, Soran Gadan, Göran Wallin, et al. "Does socioeconomic status influence the choice of surgical technique in abdominal rectal cancer surgery?" Colorectal Disease 27, no. 5 (2025). https://doi.org/10.1111/codi.70111.
Full textAbstract:
AbstractAimThis study aimed to estimate the impact of socioeconomic status on the probability of receiving open (OPEN) or minimally invasive surgery (MIS) for curative abdominal rectal cancer resection.MethodsAll patients diagnosed with rectal cancer clinical Stage I–III during the period 2010–2021 who underwent curative abdominal resection surgery, MIS or OPEN, were included. Patients were identified in the Colorectal Cancer Database, a register‐linkage based on the Swedish Colorectal Cancer Register and linked to several national Swedish health‐related and demographic registers. Socioeconomic factors, sex, patient and tumour characteristics, number of previous surgical procedures and category of hospital were collected. Exposures were level of education (categorized as 6–9, 10–12, >12 years), household income (quartiles 1–4) and country of birth (Sweden, Nordic countries outside Sweden, Europe outside the Nordic countries, outside Europe), and outcome was MIS or OPEN. Multivariable logistic regression models were fitted for each exposure, adjusted for age, sex, cT and cN, level of tumour, and number of previous abdominal surgical procedures.ResultsA total of 13 778 patients were included of whom 43.6% underwent MIS (n = 6007) and 56.4% OPEN (n = 7771). Highest level of education (OR for highest vs. lowest level of education 1.15; 95% CI 1.03–1.29) and highest household income quartile (OR for highest vs. lowest household income quartile 1.27; 95% CI 1.12–1.44) increased the likelihood of receiving MIS.ConclusionDespite the tax‐financed healthcare system in Sweden, rectal cancer patients with the highest level of education and the highest household income had an increased probability of receiving MIS.
23
Mundt, Torsten, Ahmad Al Jaghsi, Friedhelm Heinemann, and Christian Schwahn. "Mini-implant placement under existing removable partial dentures decreased the mobility of remaining teeth in a randomized controlled 3-year clinical trial." Clinical Oral Investigations 29, no. 5 (2025). https://doi.org/10.1007/s00784-025-06340-2.
Full textAbstract:
Abstract Objectives Longitudinal stability values of teeth after strategic implant insertion under existing removable partial dentures (RPD) are lacking. This explorative evaluation of a 3-year randomized controlled trial on strategic min-implants (MI) aims to estimate the stability changes of the remaining teeth and the tooth survival rates under different MI loading conditions. Materials and methods Partially edentulous study participants of a university clinic and three private practices with inadequately supported RPDs received strategic MIs (diameter 1.8–2.4 mm). According to the randomization the MIs were either immediately loaded in group A or delayed loaded in group B. The longitudinal changes of Periotest values (PTV) for teeth were compared between groups using mixed models adjusted by sex, age, jaw, tooth site, center, and baseline PTVs. The tooth survival was estimated with Kaplan-Meier analyses and group differences were analyzed using Cox regression. Results Altogether 232 MIs were placed under 48 mandibular and 31 maxillary RPDs with a total of 255 remaining teeth in both jaws. The initial median PTV of 9.5 in group A and 8.0 in group B decreased to 5.0 in group A and 2.0 in group B at the 3-year follow-up. In the fully adjusted model the tooth mobility reduction revealed 5.3 PTV units (95% CI: 3.5–7.2) in group A and 7.6 PTV units (95% CI: 5.4–9.9) in group B without inferiority of any group (P = 0.122). The 3-year tooth survival rates were 88% in group A versus 92% in group B without relevant group differences (P = 0.338). Conclusion Strategic MIs under existing RPDs in persons with severe reduced dentitions decreased the mobility of the remaining teeth independent from implant loading modus. Further tooth loss can emerge despite of relieving the remaining dentition by the MIs. Statement of clinical relevance Mini-implants as supplementary abutments can restabilize loose teeth in jaws with RPDs and unfavorable tooth distributions. Clinical trial registration German Clinical Trials Register (Deutsches Register Klinischer Studien, DRKS-ID: DRKS00007589, www.germanctr.de), January 15th, 2015.
24
Apostolaki-Hansson, Trine, Amir Hillal, Nathanael Göransson, et al. "The potential for minimally invasive intracerebral hemorrhage evacuation in routine healthcare: applicability of the ENRICH trial criteria to an unselected cohort." Frontiers in Stroke 3 (May 17, 2024). http://dx.doi.org/10.3389/fstro.2024.1403812.
Full textAbstract:
ObjectiveFollowing the favorable outcomes demonstrated by the Early MiNimally-invasive Removal of IntraCerebral Hemorrhage (ENRICH) trial in supratentorial intracerebral hemorrhage (ICH) patients treated with minimally invasive surgery (MIS), and considering the increasing interest in MIS, we aimed to assess the potential eligibility rate for ICH patients in Sweden.MethodsAll patients with spontaneous ICH in the Swedish Stroke Register (RS) during 2017–2020 in Skane county (1.37 million) were assessed. Baseline imaging was used for radiological characterization. Clinical data were obtained from RS. MIS eligibility in the total ICH population meeting ENRICH criteria were estimated and extrapolated to the Swedish population (10.5 million).ResultsOf 1,314 ICH patients, 5.9% met the ENRICH criteria for MIS (ICH volume 30–80 ml). Considering the ENRICH trial results indicating the effectiveness of MIS was mainly attributable to intervention for lobar hemorrhages, we determined that 2.8% of our ICH cohort in Sweden would be eligible for MIS. The estimated rate of neurosurgery for ICH could increase from the current 1.46–1.90 patients/100,000 population/year (in absolute numbers from 154 to 200 interventions out of 2,400 ICHs in Sweden annually).ConclusionsWe show that 2.8% of the Skane ICH population would be eligible for MIS if ENRICH criteria are employed for patients with lobar ICH, corresponding to a 29% increase of current surgical rates for ICH in Sweden. As MIS for ICH is not yet standard practice in Sweden, consideration for its implementation within the neurosurgical organization becomes essential to accommodate the anticipated increase in patient demand.
25
Kahn, Robin, Maria Mossberg, Elisabet Berthold, et al. "Capillary leak syndrome was associated with more severe multisystem inflammatory syndrome in children during the COVID‐19 pandemic." Acta Paediatrica, February 19, 2024. http://dx.doi.org/10.1111/apa.17162.
Full textAbstract:
AbstractAimThis population‐based study investigated the occurrence of capillary leak syndrome (CLS) in children with multisystem inflammatory syndrome in children (MIS‐C), associated with COVID‐19. We also examined associations between CLS and MIS‐C disease severity.MethodsAll eligible individuals aged 0–18 years, who were diagnosed with MIS‐C in Skåne, southern Sweden, from 1 April 2020 to 31 July 2021, were studied. They were all included in the Pediatric Rheumatology Quality Register and clinical and laboratory data were compared between patients with and without CLS.ResultsWe included 31 patients (61% male) with MIS‐C in the study. The median age at diagnosis was 10.6 years (range 1.99–17.15) and 45% developed CLS. All six patients who required intensive care had CLS. Patients with CLS also had a higher incidence of reduced cardiac function, measured as low ejection fraction. The CLS group exhibited significantly higher C‐reactive protein values (p < 0.001) and N‐terminal pro‐B‐type natriuretic peptide levels (p < 0.001), as well as lower platelet counts (p = 0.03), during the first week of treatment. Individuals with CLS also received more intense immunosuppression.ConclusionCLS was a common complication of MIS‐C in our study and these patients had a more severe disease course that required more intensive treatment.
26
Sakari, Thorbjörn, Filip Sköldberg, Caroline E. Dietrich, Caroline Nordenvall, and Urban Karlbom. "Incidence of adhesive small bowel obstruction after surgery for colorectal cancer in Sweden 2007–2016." Colorectal Disease, December 29, 2023. http://dx.doi.org/10.1111/codi.16845.
Full textAbstract:
AbstractAimPopulation‐based data on incidence and risk factors of adhesive small bowel obstruction (SBO) are limited. The aims of this study were to assess the risk of SBO and SBO surgery after bowel resection for colorectal cancer (CRC) and to assess whether this risk is modified by minimally invasive surgery (MIS) and radiotherapy in a retrospective national study.MethodsCRCBaSe, a nationwide register linkage originating from the Swedish Colorectal Cancer Register, was used to identify Stage I–III CRC patients who underwent resection in 2007–2016, with follow‐up throughout 2017. Matched CRC‐free comparators (1:6) were included as a reference of SBO and SBO surgery incidence. The association between MIS and preoperative radiotherapy and the incidence rate of SBO was evaluated in adjusted multivariable Cox regression models.ResultsAmong 33 632 CRC patients and 198 649 comparators, the 5‐year cumulative incidence of SBO and SBO surgery was 7.6% and 2.2% among patients and 0.6% and 0.2% among comparators, with death as a competing risk. In all patients, MIS was associated with a reduced incidence of SBO (hazard ratio [HR] 0.7, 95% CI 0.6–0.8) and SBO surgery (HR 0.5, 95% CI 0.3–0.7). In rectal cancer patients, radiotherapy was associated with an increased incidence of SBO (HR 1.6, 95% CI 1.4–1.8) and SBO surgery (HR 1.7, 95% CI 1.3–2.3).DiscussionColorectal cancer surgery is associated with a marked increase in risk of SBO, compared with the general population. The incidence is further increased if open surgery or radiotherapy is performed.
27
Ludwikowska, Kamila Maria, Magdalena Okarska-Napierała, Natalia Dudek, et al. "Distinct characteristics of multisystem inflammatory syndrome in children in Poland." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-02669-2.
Full textAbstract:
AbstractDuring the winter months of 2020/2021 a wave of multisystem inflammatory syndrome in children (MIS-C) emerged in Poland. We present the results of a nationwide register aiming to capture and characterise MIS-C with a focus on severity determinants. The first MIS-C wave in Poland was notably high, hence our analysis involved 274 children. The group was 62.8% boys, with a median age of 8.8 years. Besides one Asian, all were White. Overall, the disease course was not as severe as in previous reports, however. Pediatric intensive care treatment was required for merely 23 (8.4%) of children, who were older and exhibited a distinguished clinical picture at hospital admission. We have also identified sex-dependent differences; teenage boys more often had cardiac involvement (decreased ejection fraction in 25.9% vs. 14.7%) and fulfilled macrophage activation syndrome definition (31.0% vs. 15.2%). Among all boys, those hospitalized in pediatric intensive care unit were significantly older (median 11.2 vs. 9.1 years). Henceforth, while ethnicity and sex may affect MIS-C phenotype, management protocols might be not universally applicable, and should rather be adjusted to the specific population.
28
Luan, Haopeng, Cong Peng, Kai Liu, and Xinghua Song. "Comparing the efficacy of unilateral biportal endoscopic transforaminal lumbar interbody fusion and minimally invasive transforaminal lumbar interbody fusion in lumbar degenerative diseases: a systematic review and meta-analysis." Journal of Orthopaedic Surgery and Research 18, no. 1 (2023). http://dx.doi.org/10.1186/s13018-023-04393-1.
Full textAbstract:
Abstract Objective To compare the efficacy and safety of unilateral biportal endoscopic transforaminal lumbar interbody fusion (BE-TLIF) and minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in lumbar degenerative diseases. Methods This study was registered on International Prospective Register of Systematic Reviews (PROSPERO) (ID: CRD42023432460). We searched PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wan Fang Database, and Wei Pu Database by computer to collect controlled clinical studies on the efficacy and safety of unilateral BE-TLIF and MIS-TLIF in lumbar degenerative diseases from database establishment to May 2023. Two researchers screened the literature, extracted data and evaluated the risk of bias of the included studies, recorded the authors, and sample size, and extracted the intraoperative blood loss, operation time, postoperative drainage, Oswestry disability index, Visual analogue scale, lumbar lordosis, disk height, hospital length stay, fusion rate, and complications in each study. Meta-analysis was performed using Revman 5.4 software provided by Cochrane Library. Results A total of 14 cohort studies with a total of 1007 patients were included in this study, including 472 patients in the BE-TLIF group and 535 patients in the MIS-TLIF group. The BE-TLIF group had lower intraoperative blood loss than the MIS-TLIF group [mean difference (MD) = − 78.72, 95% CI (− 98.47, − 58.97), P < 0.00001] and significantly reduced postoperative drainage than the MIS-TLIF group [MD = − 43.20, 95% CI (− 56.57, − 29.83), P < 0.00001], and the operation time was longer than that of the MIS-TLIF group [MD = 22.68, 95% CI (12.03, 33.33), P < 0.0001]. Hospital length stay in BE-TLIF group was significantly less than that in MIS-TLIF group [MD = − 1.20, 95% CI (− 1.82, − 0.57), P = 0.0002]. Conclusion Compared with MIS-TLIF, BE-TLIF for lumbar degenerative diseases has the advantages of less intraoperative blood loss, less early postoperative low back and leg pain, shorter postoperative hospital length stay, and faster early functional recovery.
29
Klimov, Vladimir, Aleksey Evsyukov, Evgeniya Amelina, Sergey Ryabykh, and Alexander Simonovich. "Predictors of Complications and Unfavorable Outcomes of Minimally Invasive Surgery Treatment in Elderly Patients With Degenerative Lumbar Spine Pathologies (Case Series)." Frontiers in Surgery 9 (April 26, 2022). http://dx.doi.org/10.3389/fsurg.2022.869345.
Full textAbstract:
IntroductionThe use of minimally invasive surgery (MIS) results in fewer adverse and more improved outcomes. However, the literature data describing the factors increasing the number of complications, reoperation frequency and unscheduled re-hospitalizations in older patients after MIS are contradictory. In this study, a large number of patients was investigated for the complications of minimally invasive surgical treatment of degenerative disease of the lumbar spine in older patients. The objective of the study was to determine the predictors of unfavorable outcomes in such patients.Materials and Methods1,013 patients underwent MIS (decompression alone, TLIF, LLIF, ALIF) in 2013-2017. All operations were performed with the participation of the authors (neurosurgeons). The patient's average age was 66. The following data were collected: BMI; CCI; presence of postoperative complications according to the Dindo-Clavien classification; unplanned readmission at 90 days; hospital length of stay (LOS); surgical complexity (low, intermediate, and high); surgical time; and risk factors. The cumulative reoperation rate was determined at 5-years follow-up.ResultsA total of 256 patients suffered a complication (25.2%), 226 classified as mild (grade I, II, IIIA), and 30 - as severe (IIIB, IVA). Such factors as the surgical complexity, BMI &gt; 30, surgical time, number of operated levels were associated with a significant risk of developing a complication. For patients with and without complications, LOS was 9.3 and 6.3 days, respectively (p &lt; 0.0001), the unplanned readmission rate was 1.3%. 104 patients underwent 133 revision operations. The 5-year cumulative reoperation rate was 15.2%, and the reoperation index was 12.1%. The CCI had no statistically significant effect on the complication incidence after MIS. A higher risk of complications was found in patients who underwent intermediate-complexity surgery (MIS TLIF) compared with uncompounded (decompression alone) and more complex (MIS LLIF, MIS ALIF) surgical procedures (p &lt; 0.001 and p = 0.001, respectively).ConclusionA register of postoperative complications is an important tool for health quality assessment and choosing the best surgical option that helps to establish measures to reduce such complications. Using MIS for the treatment of elderly patients reduces the number of severe complications.
30
Klimov, Vladimir, Aleksey Evsyukov, Evgeniya Amelina, Sergey Ryabykh, and Alexander Simonovich. "Predictors of Complications and Unfavorable Outcomes of Minimally Invasive Surgery Treatment in Elderly Patients With Degenerative Lumbar Spine Pathologies (Case Series)." Frontiers in Surgery 9 (April 26, 2022). http://dx.doi.org/10.3389/fsurg.2022.869345.
Full textAbstract:
IntroductionThe use of minimally invasive surgery (MIS) results in fewer adverse and more improved outcomes. However, the literature data describing the factors increasing the number of complications, reoperation frequency and unscheduled re-hospitalizations in older patients after MIS are contradictory. In this study, a large number of patients was investigated for the complications of minimally invasive surgical treatment of degenerative disease of the lumbar spine in older patients. The objective of the study was to determine the predictors of unfavorable outcomes in such patients.Materials and Methods1,013 patients underwent MIS (decompression alone, TLIF, LLIF, ALIF) in 2013-2017. All operations were performed with the participation of the authors (neurosurgeons). The patient's average age was 66. The following data were collected: BMI; CCI; presence of postoperative complications according to the Dindo-Clavien classification; unplanned readmission at 90 days; hospital length of stay (LOS); surgical complexity (low, intermediate, and high); surgical time; and risk factors. The cumulative reoperation rate was determined at 5-years follow-up.ResultsA total of 256 patients suffered a complication (25.2%), 226 classified as mild (grade I, II, IIIA), and 30 - as severe (IIIB, IVA). Such factors as the surgical complexity, BMI &gt; 30, surgical time, number of operated levels were associated with a significant risk of developing a complication. For patients with and without complications, LOS was 9.3 and 6.3 days, respectively (p &lt; 0.0001), the unplanned readmission rate was 1.3%. 104 patients underwent 133 revision operations. The 5-year cumulative reoperation rate was 15.2%, and the reoperation index was 12.1%. The CCI had no statistically significant effect on the complication incidence after MIS. A higher risk of complications was found in patients who underwent intermediate-complexity surgery (MIS TLIF) compared with uncompounded (decompression alone) and more complex (MIS LLIF, MIS ALIF) surgical procedures (p &lt; 0.001 and p = 0.001, respectively).ConclusionA register of postoperative complications is an important tool for health quality assessment and choosing the best surgical option that helps to establish measures to reduce such complications. Using MIS for the treatment of elderly patients reduces the number of severe complications.
31
Dr, Sajjad Hussain Dr Muhammad Abid Aziz Dr Ashiq Muhammad. "IMPACT OF A MINIMUM INVASIVE SURGERY CULTURE ON THE POPULATION EXPERIENCE IN SERVICE." January 7, 2021. https://doi.org/10.5281/zenodo.4422153.
Full textAbstract:
<strong><em>Aim:</em></strong><em> Careful students are expected to learn specialized laparoscopic qualifications as laparoscopy becomes the norm in many fields of general health care. The technique has since been met with collaboration with overlooked surgical practices on which the laparoscopic cases are negatively affected by such connections. Our study aimed to determine whether the portrayal of the MIS Affiliation had a detrimental effect on the experiences of people living in a solitary university in a general medical procedure.</em> <strong><em>Methods:</em></strong><em> We define the advances made for research purposes after the formation of the MIS Association. A challenge was raised by the Occupancy Register System of the High Clinical Education Accreditation Board to collect all employable occupant case reports in classes 1 to 5. Two years before the MIS association was formed in our company in 2012 have been considered. Our current research was conducted at Jinnah Hospital, Lahore from May 2019 to April 2020. Estimates of 0,05 is viewed as not quite gigantic.</em> <strong><em>Results:</em></strong><em> A MIS administration has been set up since the launch of the MIS relationship. This management consisted of an individual, a middle- and an assistant. Analyzed valuable knowledge. Inhabitants recorded 276 and 588 laparoscopic complex cases separately from 2010-2013 to 2012-2014. From 2010 to 2013 there were 43 inhabitants and from 2013 to 2014 there were 48. During the analysis of the double intersecting times, an exponential trend was found for all methods except for GYN/GNL. The usual expansion of the percentage for complicated general medical operations was 248 ± 176.9%. The specifics per capita cases are greater or more comparable to the cases commonly detailed for laparoscopic methods following the formation of a MIS organization.</em> <strong><em>Conclusion:</em></strong><em> The creation of a MIS relationship has an ideal effect on the teaching of general medicine in a solitary university center. The existence of an organization in a university center can support workers because they may take part in a growing number of complex laparoscopic cases.</em> <strong>Keywords: </strong><em>Minimum Invasive Surgery Culture, Population Experience, Service.</em>
32
Leshner, Michael D. "Forensic Engineering Investigation Of Intentional Mis-Calibration Of Vehicle Odometers." Journal of the National Academy of Forensic Engineers 26, no. 1 (2009). http://dx.doi.org/10.51501/jotnafe.v26i1.707.
Full textAbstract:
Odometers In Motor Vehicles Record And Display Distance Traveled. In Addition To Informing A Driver Of Trip Distance, This Measurement Is Used To Calculate Service Intervals, Lease Payments, Resale Value, Fuel Economy, And Warranty Limits. Distance Is Calculated From A Digital Accumulation Of Wheel Rotations And Knowledge Of The Tire Circumference. The Tire Circumference May Vary With Speed, Load, Pressure, Tread-Wear And Brand. This Investigation Compares Indicated Odometer Measurements With Simultaneous Measurements Using A Global Positioning System (Gps) Device On A Range Of Vehicle Models. While Some Models Have Odometer Systems With Reasonably Accurate Calibrations, Others Systematically Over-Register Odometer Distance. In The Opinion Of This Investigator, The Mis-Calibration Is Sometimes Intentional And Done For The Economic Benefit Of The Manufacturer.
33
Semelsberger, Scott D., Michael S. Lee, Cale B. Dobson, Christopher P. Miller, and Arianna L. Gianakos. "Modern Treatment of Hallux Rigidus by Cheilectomy: A Systematic Review of Patient-Reported Outcomes in Minimally Invasive Techniques." Foot & Ankle Orthopaedics 9, no. 4 (2024). https://doi.org/10.1177/24730114241303169.
Full textAbstract:
Background: Minimally invasive cheilectomy is becoming a more prominent surgical approach in the management of mild to moderate hallux rigidus. This systematic review aims to analyze and present the current literature on patient-reported outcomes following minimally invasive (MIS) cheilectomy for mild to moderate hallux rigidus. Methods: PubMed, Cochrane Central Register of Controlled Trials, and Scopus databases were searched in April 2024. Inclusion criteria consisted of articles evaluating patients undergoing cheilectomy through an MIS approach either using fluoroscopy or arthroscopy, studies that reported patient-reported outcomes, and studies written in English. The primary outcome measure was scored patient-reported outcomes. The secondary outcome measures included complications, secondary surgeries, surgical techniques, return to activity, patient satisfaction, and grades of hallux rigidus. Results: Eight studies met the inclusion criteria, and a total of 296 patients were evaluated. Overall, 36 of 296 (12.2%) underwent arthroscopy with a shaver, 130 of 296 (43.9%) underwent an MIS percutaneous approach with burr, and 130 of 296 (43.9%) had a combination of both techniques. The mean reported range of motion (dorsiflexion) improved from 32.4 degrees (range, 6.3-50.0 degrees) to 61.2 degrees (range, 47.6-89.6 degrees). All studies that reported patient outcomes scores demonstrated improved outcomes regardless of surgical technique. Overall combined reported complication rate was 18 of 296 (6.1%), with the most common complication being dorsomedial cutaneous nerve problems, affecting 6 of 296 patients (2.0%). Conclusion: Minimally invasive cheilectomy results in positive patient outcomes, patient satisfaction, preserves range of motion, and has low complication rates for the treatment of mild to moderate hallux rigidus.
34
Wang, ChunQi, Ling Feng, ShuangYan Tu, et al. "Antihypertensive strategies for the prevention of secondary stroke: a systematic review and meta-analysis." European Journal of Medical Research 30, no. 1 (2025). https://doi.org/10.1186/s40001-024-02226-3.
Full textAbstract:
Abstract Background Stroke is an important contributor to disability and death globally. Hypertension is a main risk factor for recurrent stroke in patients with ischemic and hemorrhagic stroke or transient ischemic attack. Higher systolic blood pressure, diastolic blood pressure, pulse pressure and mean arterial pressure at admission are independently associated with the risk of stroke recurrence. Therefore, lowering blood pressure is recommended by guidelines to prevent the recurrence of stroke. Methods A systematic search of PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science databases was conducted through January 12, 2024. The search identified randomized controlled trials (RCTs) comparing antihypertensive drugs with control measures (placebo or no treatment) or standard blood pressure control (SBPC) with intensive blood pressure control (IBPC) for recurrent stroke prevention. Primary outcomes included overall and subtype stroke recurrence rates, fatal and non-fatal strokes, cardiovascular deaths, and myocardial infarctions (MIs). Secondary outcomes comprised non-fatal MIs and all-cause mortality. Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using random or fixed-effect models in Stata 15.0. Results The analysis included 19 RCTs encompassing 72,048 patients. Twelve studies (n = 53,971) evaluated antihypertensive drugs against placebo or no treatment, while seven studies (n = 18,077) compared SBPC with IBPC. Antihypertensive therapy demonstrated significant risk reductions compared to placebo or no treatment for recurrent stroke (RR = 0.86, 95% CI: 0.75–0.97), cardiovascular deaths (RR = 0.92, 95% CI: 0.87–0.97), and MIs (RR = 0.87, 95% CI: 0.79–0.96). IBPC showed superior outcomes compared to SBPC, with significant reductions in recurrent stroke (RR = 0.87, 95% CI: 0.77–0.98), cardiovascular deaths (RR = 0.75, 95% CI: 0.61–0.91), and all-cause mortality (RR = 0.85, 95% CI: 0.73–0.95). Conclusion In stroke patients, antihypertensive therapy demonstrates significant protective effects against stroke recurrence, cardiovascular deaths, and MIs compared to placebo or no treatment. Additionally, IBPC provides enhanced protection against stroke recurrence, cardiovascular deaths, and all-cause mortality compared to SBPC.
35
Pierre, Adèle. "L'adresse de référence, la citoyenneté des invisibles." Sociétés plurielles Exaptriate, Articles (2021). http://dx.doi.org/10.46298/societes-plurielles.2021.8415.
Full textAbstract:
In Belgium, registration in the Population Register is a prerequisite for access to social rights, as well as an indicator of integration and social recognition. For homeless people, an administrative system has been set up: the reference address. Among other things, this allows the person to be registered in the population register and to obtain a legal and administrative existence. However, today, its application differs from one social welfare organization (called CPAS) to another, the controls being most of the time driven by the fight against social fraud, itself defined by a specific policy of each CPAS. En Belgique, la domiciliation et l’inscription au Registre de la population constituent un préalable à l’accès aux droits sociaux, ainsi qu’un indicateur d’intégration et de reconnaissance sociale. Pour les personnes sans‑domicile, un dispositif administratif a été mis en place : l’adresse de référence. Celui‑ci permet, entre autres, de disposer d’une inscription au registre de la population et pour la personne d’obtenir une existence de droit et administrative. Pourtant, aujourd’hui, son application diffère d’un organisme d’aide sociale (appelés CPAS) à un autre, les contrôles étant la plupart du temps motivés par la lutte contre la fraude sociale, elle‑même définie par une politique propre à chaque CPAS.
36
Williams, Vijai, Nabaneeta Dash, Renu Suthar, et al. "Clinicolaboratory Profile, Treatment, Intensive Care Needs, and Outcome of Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2: A Systematic Review and Meta-analysis." Journal of Pediatric Intensive Care, November 19, 2020. http://dx.doi.org/10.1055/s-0040-1719173.
Full textAbstract:
AbstractThis study was aimed to summarize the current data on clinicolaboratory features, treatment, intensive care needs, and outcome of pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2; PIMS-TS) or multisystem inflammatory syndrome in children (MIS-C). Articles published in PubMed, Web of Science, Scopus, Google Scholar, and novel coronavirus disease 2019 (COVID-19) research database of World Health Organization (WHO), Centers for Disease Control and Prevention (CDC) database, and Cochrane COVID-19 study register between December 1, 2019 and July 10, 2020. Observational studies involving patients <21 years with PIMS-TS or MIS-C were reported the clinicolaboratory features, treatment, intensive care needs, and outcome. The search identified 422 citations and finally 18 studies with 833 participants that were included in this study, and pooled estimate was calculated for parameters of interest utilizing random effect model. The median age was 9 (range: 8–11) years. Fever, gastrointestinal symptoms, rash, conjunctival injection, and respiratory symptoms were common clinical features. Majority (84%) had positive SARS-CoV-2 antibody test and only one-third had positive reverse transcript polymerase chain reaction (RT-PCR). The most common laboratory abnormalities noted were elevated C-reactive protein (CRP), D-dimer, procalcitonin, brain natriuretic peptide (BNP), fibrinogen, ferritin, troponin, interleukin 6 (IL-6), lymphopenia, hypoalbuminemia, and thrombocytopenia. Cardiovascular complications included shock (65%), myocardial dysfunction (61%), myocarditis (65%), and coronary artery abnormalities (39%). Three-fourths of children required admission to pediatric intensive care unit (PICU) where they received vasoactive medications (61%) and mechanical ventilation (25%). Treatment strategies used included intravenous immunoglobulin (IVIg; 82%), steroids (54%), antiplatelet drugs (64%), and anticoagulation (51%). Mortality for patients with PIMS-TS or MIS-C was low (n = 13). In this systematic review, we highlight key clinical features, laboratory findings, therapeutic strategies, intensive care needs, and observed outcomes for patients with PIMS-TS or MIS-C. Commonly observed clinical manifestations include fever, gastrointestinal symptoms, mucocutaneous findings, cardiac dysfunction, shock, and evidence of hyperinflammation. The majority of children required PICU admission, received immunomodulatory treatment, and had good outcome with low mortality.
37
De, Wilde RL, and B. Bojahr. "Intra-Abdominal Sarcoma Spread Risk due to Morcellation in Minimal-Invasive Myoma Surgery." November 21, 2014. https://doi.org/10.19070/2377-1887-140001e.
Full textAbstract:
In April 2014 the food and drug administration (FDA) discouraged the use of laparoscopic morcellation in minimal-invasive hysterectomy or myoma surgery (MIS) [2]. The American Association of Gynecological Laparoscopists [3] and the European Society of Gynecological Endoscopy [4] stated the importance of further evaluation and the necessity of scientific data-based studies before final conclusions could be taken. As the results of prospective, register-based studies can take several years to be generated, we performed a retrospective singlecenter evaluation of 10,731 uterine morcellations, being the biggest series ever, which data will be published soon. Out of the 10,731 intra-abdominal uterine morcellations in laparoscopic hysterectomy, 81.3 % showed myomata; in those 8,720 six patients histologically showed to have a leiomyosarcoma (≥ 10 mitoses per high power field). After secondary oncological surgery and a follow-up of ≥ 2 years, five women were cured; one patient died due to diffuse intra-abdominal sarcoma spread.
38
Semelsberger, Scott D., Michael Lee, Cale Dobson, Christopher P. Miller, and Arianna Gianakos. "Modern Treatment of Hallux Rigidus by Cheilectomy: A Systematic Review of Minimally Invasive Patient-Reported Outcomes." Foot & Ankle Orthopaedics 9, no. 4 (2024). https://doi.org/10.1177/2473011424s00368.
Full textAbstract:
Category: Arthroscopy; Midfoot/Forefoot Introduction/Purpose: Hallux rigidus is a degenerative disorder of the first metatarsophalangeal (MTP) joint. Patients with this condition experience symptoms including pain, stiffness, and reduced range of motion of the 1st MTP joint. Cheilectomy is a surgical treatment option that removes dorsal periarticular osteophytes to alleviate pain and improve range of motion. Minimally invasive cheilectomy is becoming a more prominent surgical approach due to its clinical benefits including smaller incisions, reduced complications, and faster return to function. This systematic review aims to analyze and present the current literature on patient-reported outcomes (PROs) following MIS cheilectomy for mild to moderate hallux rigidus. Methods: A systematic review of the literature was conducted using articles pulled from PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Scopus databases in December 2023 using the search term “cheilectomy.” This systematic review was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered in Prospero (Blinded ID:XX). Articles were included in the systematic review if they reported on preoperative or postoperative patient-reported outcomes in patients undergoing minimally invasive cheilectomy (MIS) in English. Minimally invasive was defined as an arthroscopic or percutaneous approach. The primary outcome measure was scored patient-reported outcomes. The secondary outcome measures included complications, secondary surgeries, surgical techniques, qualitative patient experiences, and grades of hallux rigidus. Results: Eight studies met the inclusion criteria, and a total of 284 patients were evaluated. 130/284 underwent an MIS percutaneous approach with burr, 70/284 underwent arthroscopy with shaver, and 84/284 had a combination of both techniques. Most patients (79%) had Coughlin-Shurnas grade one or two hallux rigidus (range: 1-3). The mean American Orthopaedic Foot & Ankle Society scores improved from 57.7 (range: 43-71) to 90.1 (range: 87-97). The mean range of motion (dorsiflexion) improved from 28.5 (range: 8-42) to 49.5 (range: 30-73) degrees. Complication rates were low at 18/284 (6%). The most common complication was numbness, affecting 6/284 (2%) patients. Four out of eight articles reported zero complications. 113/125 (90.4%) patients would recommend the procedure. Conclusion: Treatment of hallux rigidus with MIS cheilectomy appears to result in favorable and safe outcomes when performed for patients with early degenerative disease who have failed conservative treatment. Patients reported high satisfaction rates, significant symptomatic improvements, and experienced low complication rates.
39
Balthazar da Silveira, Carlos André, Sergio Mazzola Poli de Figueiredo, Ana Caroline Dias Rasador, et al. "Impact of patient's sex on groin hernia repair: A systematic review and meta‐analysis." World Journal of Surgery, September 20, 2024. http://dx.doi.org/10.1002/wjs.12344.
Full textAbstract:
AbstractBackgroundGroin hernia repair (GHR) is a performed procedure worldwide, with approximately 20 million surgeries carried out each year. Despite being less common in females, there is a lack of research on how sex influences the outcomes of GHR. This systematic review and meta‐analysis aim to assess how patient sex impacts results in GHR.MethodsWe performed a systematic review and meta‐analysis according to Preferred Reporting Items for Systematic Review and Meta‐Analyses guidelines. We searched for studies up to October 2023 in MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials. The studies included focused on sex outcomes for both robotic and open GHR procedures. Data extraction and quality assessment were conducted using the Risk of Bias in Non‐Randomized Studies ‐ Of Interventions tool. Our statistical analysis was performed using the metafor package in RStudio.ResultsAfter screening a total of 3917 articles, we identified 29 studies that met our criteria, comprising a total of 1,236,694 patients. Among them, 98,641 (7.98%) patients were females. Our findings showed that females had higher rates of hernia recurrence (RR 1.28), chronic pain (RR 1.52), and surgical site infections (SSIs) (RR 1.46) compared to males. Females showed a lower tendency to undergo minimally invasive surgery (MIS) with a relative risk of 0.82 (95% CI 0.69–0.97; p = 0.02).ConclusionFemales tend to face higher rates of complications after GHR such as an elevated risk of chronic pain, recurrence, and surgical site infections (SSI). Moreover, they undergo fewer MIS options compared to males. These results underscore the importance of research to enhance outcomes for women undergoing GHR.
40
Miljan, Merilin, and Virve Vihman. "A corpus study of grammatical case forms in written and spoken Estonian: Frequency, distribution and grammatical role." Eesti ja soome-ugri keeleteaduse ajakiri. Journal of Estonian and Finno-Ugric Linguistics 14, no. 3 (2023). http://dx.doi.org/10.12697/jeful.2023.14.3.01.
Full textAbstract:
In this paper, we present the results of a corpus study investigating the distribution of the three grammatical cases in Estonian (nominative, genitive, partitive) and the factors affecting the interpretation of syntactic role for nouns marked in these cases. Unlike previous studies, which have focussed on the properties of grammatical relations, we take the perspective of morphological case, and investigate the relative frequency of each case in both written and spoken corpora, according to the encoded grammatical roles, referential properties (animacy, number, countability) and syntactic context (word order, transitivity), as well as probing the differences according to register. We find that each case is prototypically, but not reliably, associated with a particular grammatical role, and that a cluster of features are available to assist speakers in identifying the function of a case-marked noun. Kokkuvõte. Merilin Miljan, Virve Vihman: Eesti keele grammatilised käänded kirjalikus ja suulises korpuses: sagedus, jaotumus ning süntaktilised rollid. Artiklis esitatakse tulemused korpusuuringust, mille eesmärgiks oli välja selgitada eesti keele grammatiliste käänete (nominatiiv, partitiiv, genitiiv) jaotumus ning tegurid, mis mõjutavad nende käänetega markeeritud nimisõnade süntaktiliste rollide tõlgendamist. Erinevalt varasematest töödest, mis keskenduvad grammatilistele suhetele ja (seejärel) nende käändetähistusele, lähtub selle uurimuse fookus eelkõige morfoloogiast, st käändest endast. N-ö käände perspektiivist vaatleme iga grammatilise käände esinemise sagedust kirjalikus ja suulises korpuses: milliseid süntaktilisi funktsioone see markeerib, markeeritava nimisõna omadusi (elusus, arv, loendatavus), süntaktilist konteksti (sõnajärg, transitiivsus) ning registri erinevusi. Leiame, et kuigi üldpildina eristub iga grammatilise käände puhul sagedaim süntaktiline põhiroll, toob detailsem analüüs välja nimisõna omaduste ja süntaktilise konteksti olulisuse nende rollide jaotumuses.
41
Vinas-Rios, Juan Manuel, Michael Rauschmann, Richard Sellei, Mohammad Arabmotlagh, Fatima Medina-Govea, and Frerk Meyer. "Impact of Obesity on Perioperative Complications on Treatment of Spinal Metastases: A Multicenter Surveillance Study from the German Spine Registry (DWG-Register)." Asian Journal of Neurosurgery, October 7, 2022. http://dx.doi.org/10.1055/s-0042-1756627.
Full textAbstract:
Abstract Background The spine is a common location for the development of primary and metastatic tumors, spinal metastases being the most common tumor in the spine. Spinal surgery in obesity is challenging due to difficulties with anesthesia, intravenous access, positioning, and physical access during surgery. The objective was to investigate the effect of obesity on perioperative complications by discharge in patients undergoing surgery for spinal metastases. Methods Retrospective analysis of data from the DWG-register on patients undergoing surgery for metastatic disease in the spine from January 2012 to December 2016. Preoperative variables included obesity (≥ 30 kg/m2), age, gender, and smoking status. In addition, the influence of pre-existing medical comorbidity was determined, using the American Society of Anesthesiologists (ASA) score. Results In total, 528 decompressions with and without instrumentation undergoing tumor debulking, release of the neural structures, or tumor extirpation in metastatic disease of the spine were identified; 143 patients were obese (body mass index [BMI] ≥ 30 kg/m2), and 385 patients had a BMI less than 30 kg/m2. The mean age in the group with BMI 30 kg/m2 or higher (group 1) was 67 years (56.6%). In the group with BMI less than 30 kg/m2 (group 2), the mean age was 64 years. Most of the patients had preoperatively an ASA score of 3 and 4 (patients with severe general disease). The likelihood of being obese in the logistic regression model seems to be protective by 47.5-fold for blood loss 500 mL or higher. Transfusions occurred in 321/528 (60.7%) patients (group 1, n = 122 and group 2, n = 299; p = 0.04). A total of 19 vertebroplasties with percutaneous stabilization (minimally invasive spine [MIS]), 6 vertebroplasties, and 31 MIS alone were identified. The variables between these groups, with exception of preoperative status (ASA-score; p = 0.02), remained nonsignificant. Conclusion Obese patients were predisposed to have blood loss more than 500 mL more often than nonobese patients undergoing surgery for spinal metastases but with perioperative blood transfusions, invasiveness, nor prolonged hospitalization. Early postoperative mobilization and a low threshold for perioperative venous thromboembolism (VTE) are important in obese patients to appropriately diagnose, treat complications, and minimize morbidity.
42
Bart van Oort. "Understanding Classical and Early Romantic Dynamics 1750-1830." Royal Conservatoire Research Portal, no. 2 (March 31, 2017). http://dx.doi.org/10.22501/koncon.351451.
Full textAbstract:
In eighteenth century scores, dynamics were notated almost exclusively in a general way. The dynamics belonging to the melancholy or passionate development of a musical phrase or the minimal dynamical differences between a dissonant and a consonant in (for instance) a Mozart Adagio or a Chopin Nocturne are so subtle that it is even better to not notate anything. The deepest utterances of both the composer's and the pianist's soul cannot be caught in any notation. However, in my opinion many of the notated dynamical indications are not fully understood or mis-interpreted. At the same time, implied dynamics can be found (while today often not realized) in virtually every musical phrase. In this research project I have investigated classical dynamics, focusing on the local function of forte and piano, on crescendos and diminuendos, the influence of harmony, the dissonance-consonance resolution, the relative meaning of ff, the dynamics of high notes, and other factors, such as the density of the notation, the direction of the melody, the register of the phrase and the character of the work. This research is part of a larger research project on the nature of the classical language, addressing dynamics, rubato and phrasing.
43
Klaas-Lang, Birute, Kadri Koreinik, and Kerttu Rozenvalde. "„Kolisin siia ja sain aru, et ma põhimõtteliselt eesti keelt ei räägi.“ Vene dominantkeelega Tartu Ülikooli üliõpilaste eesti keele repertuaarid ja suhtlusstrateegiad." Eesti ja soome-ugri keeleteaduse ajakiri. Journal of Estonian and Finno-Ugric Linguistics 16, no. 2 (2025). https://doi.org/10.12697/jeful.2025.16.2.03.
Full textAbstract:
Artiklis analüüsime vene dominantkeelega üliõpilaste keelelist kohanemist eestikeelses rahvusvahelises ülikoolis, fookuses on üliõpilaste keelerepertuaari piisavus nii õpinguteks kui ka suhtlemiseks erinevates kontekstides, st erinevates keeleregistrites. Püüame kindlaks teha, mis repertuaariga vene dominantkeelega tudeng üldhariduskoolist ülikooli tuleb, mis probleeme vene dominantkeelega üliõpilased oma keelelise kohanemise protsessis sedastavad ja millised on üliõpilaste strateegiad, et neid probleeme ületada. Meie analüüs põhineb 2022. aasta veebruarist aprillini 24 poolstruktureeritud intervjuuga kogutud andmestikul. Meetodina kasutame kvalitatiivset sisuanalüüsi. Leidsime, et eesti-vene kakskeelne üldhariduskool ei anna vene dominantkeelega noorele kaasa vajalikku keelerepertuaari ega piisavat registripädevust, kui puuduvad koolivälised sotsiaalsed kontaktid eesti keele kõnelejatega. Suhtlusmugavuse saavutamine nõuab nii kõneleja enda pingutust kui ka ümbritsevate toetust ja abi. Abstract. Birute Klaas-Lang, Kadri Koreinik, Kerttu Rozenvalde: “I moved here and realised that I basically don't speak Estonian.” Estonian language repertoires and communication strategies of Russian dominant students at the University of Tartu. In the article, we analyse the linguistic adaptation of Russian-dominant students at an Estonian-speaking international university, focusing on the students’ Estonian language repertoire for both studies and communication in different contexts, i.e. in different language registers. We are trying to determine what repertoire a student with Russian as the dominant language has acquired in a general education, what problems Russian-dominant-language students face in the process of their linguistic adaptation, and what are the students’ strategies to overcome these problems. Our analysis is based on the data collected through 24 semi-structured interviews between February and April 2022. We use qualitative deductive and inductive content analysis as a method. We found that the Estonian Russian bilingual general education school and the lack of extracurricular social contacts with Estonian speakers do not guarantee a student with a dominant Russian language the necessary language repertoire, nor the sufficient register competence. Achieving comfort of communication requires both the speaker’s own effort and the support and help of those around them.
44
Peter, Lina-Jolien, Thomas McLaren, Samuel Tomczyk, Holger Muehlan, Silke Schmidt, and Georg Schomerus. "Psychometric validation of the continuum beliefs of mental illness scale (CB-MIS) and its associations with stigma." BMC Psychiatry 25, no. 1 (2025). https://doi.org/10.1186/s12888-024-06467-8.
Full textAbstract:
Abstract Background Continuum beliefs of mental health and illness are robustly negatively correlated with mental illness stigma. However, there is a lack of multidimensional and validated measures, not entirely relying on vignettes. Methods To develop such a scale, a pool of 37 items adapted from other studies on continuum beliefs, was initially examined in expert discussions and a convenience sample (N = 227, M age=32 years, 80.6% female). Items were selected based on theoretical tenability and assigned to pre-defined facets of “State”, “Person”, and nosological “Concept” in relation to mental illness. In a second sample (N = 1375; M age=42 years; 65.2% female), the Continuum Beliefs of Mental Illness Scale (CB-MIS) was psychometrically tested (i.e. factorial, convergent, discriminant validity). Results The scale comprises three subscales with three items, and one optional vignette-based item each, rated on a 5-point Likert scale. It showed very good factorial and discriminant validity, associations with stigma were moderately negative. The scale exhibited good test-retest reliability over a period of six months. Conclusions A validated, practical, multifaceted measure is offered to evaluate beliefs regarding the continuum of mental health and illness. Future studies should conduct subgroup-specific investigations regarding sociodemographic and illness variables, and could apply this measure to anti-stigma interventions. Trial registration German Clinical Trials Register: DRKS00023557. Registered 11/12/2020. World Health Organization, Universal Trial Number: U1111–1264–9954. Registered 16/02/2021.
45
Sharma, Sonam, Dipanjan Roy, and Digambar Pawar. "PROTECTS: Progressive Rtl Obfuscation with ThrEshold Control Technique during architectural Synthesis." ACM Transactions on Design Automation of Electronic Systems, October 17, 2024. http://dx.doi.org/10.1145/3701032.
Full textAbstract:
Due to the supply chain globalization of the semiconductor industry, securing heterogeneous System-on-Chip (SoC) is becoming necessary. A malicious alteration, inserting Hardware Trojan, infringement, or counterfeiting of design via Reverse Engineering (RE) is the primary reason. As RE allows attackers to uncover proprietary algorithms, design specifications, and other intellectual property, exploiting the design becomes easier. This has a havoc impact on the manufacturer’s revenue as well as erodes consumer trust in the authenticity of the devices. This enforces a robust framework from the topmost design abstraction level to protect against RE attacks. This paper proposed a robust, architectural synthesis-driven dual-phase functional obfuscation framework for securing Register Transfer Level design. In this framework, obfuscation is achieved for both the datapath (DP) and control unit (CU) of design. Further, the robustness of obfuscated design is tested against sophisticated DP & CU level attacks. Moreover, to protect the design from brute force attack, a Consecutive Design Mis-Authentication Prevention Mechanism (CDMAP) is proposed. The proposed framework is validated using six standard Hardware Accelerator (HA) benchmarks and evaluated based on design overhead and robustness for different key sizes. A significant improvement is achieved in terms of security (∼ 1800 times) & (∼ 5.2 times) and strength of obfuscation (∼ 1.87×10 56 times) & (∼ 5.94×10 33 times) at a lower design cost of around (∼ 20.4%) & (∼ 10.4%) compared to two closely related approaches.
46
Catena, Àngels. "L’EXPRESSION DE L’EXTRÊME. FORMES ET FONCTIONS DE L’INTENSITÉ DANS MANON LESCAUT." Estudios Románicos 30 (July 29, 2021). http://dx.doi.org/10.6018/er.471211.
Full textAbstract:
Nous prenons comme point de départ l’extraordinaire profusion des marques d’intensité insérées dans L’histoire de Manon Lescaut et du chevalier des Grieux afin d’analyser leurs différentes fonctions communicatives en tenant compte de leur inscription dans un contexte discursif déterminé pour étudier ensuite leur rôle dans quelques stratégies narratives spécifiques. Nous nous intéressons d’abord à la relation entre l’intensité et le registre pathétique qui traverse les genres littéraires au XVIII siècle, puis aux valeurs sémantico-pragmatiques de la construction consécutive intensive et aux effets de généricité signalés par Adam (2011) pour d’autres genres de discours. Finalement, nous analysons les stratégies d’intensification mis en œuvre dans le roman afin de capter l’intérêt du lecteur et de générer des situations plutôt humoristiques. Based on the extraordinary profusion of marks of intensity in L’histoire de Manon Lescaut et du chevalier des Grieux, we will analyse the different communicative functions of intensification in Prévost’s novel based on its inscription in a specific discursive context, so as to end the relationship between such linguistic operation and several, more specific narrative strategies. Thus, it will be examined the relationship with the register of the pathetic that crosses the XVIII century literary genres, as well as the semantic-pragmatic values of the intensive consecutive construction and the effects of “genericity” noted by Adam (2011) in relation to other discursive genres. To conclude, it will be analysed the intensification strategies in the novel, destined to capture the interest of the reader and to generate humorous situations. Nous prenons comme point de départ l’extraordinaire profusion des marques d’intensité insérées dans L’histoire de Manon Lescaut et du chevalier des Grieux afin d’analyser leurs différentes fonctions communicatives en tenant compte de leur inscription dans un contexte discursif déterminé pour étudier ensuite leur rôle dans quelques stratégies narratives spécifiques. Nous nous intéressons d’abord à la relation entre l’intensité et le registre pathétique qui traverse les genres littéraires au XVIII siècle, puis aux valeurs sémantico-pragmatiques de la construction consécutive intensive et aux effets de généricité signalés par Adam (2011) pour d’autres genres de discours. Finalement, nous analysons les stratégies d’intensification mis en œuvre dans le roman afin de capter l’intérêt du lecteur et de générer des situations plutôt humoristiques.
47
Tian, Zixing, Lianne Kearsley-Fleet, Kim Lauper, et al. "OA01 No difference in risk of myocardial infarction among patients receiving either IL6 or TNF inhibitors for rheumatoid arthritis." Rheumatology 62, Supplement_2 (2023). http://dx.doi.org/10.1093/rheumatology/kead104.001.
Full textAbstract:
Abstract Background/Aims Interleukin 6 inhibitors (IL-6i) can increase LDL cholesterol levels, which raises concerns about the risk of myocardial infarction (MI) in patients with rheumatoid arthritis (RA) receiving this therapy. This study aims to compare the risk of MI between people with RA in the UK clinical setting receiving IL-6i or tumour necrosis factor inhibitors (TNFi) overall or by line of therapy (LoT). Methods Patients with RA registered between 01/10/2001 and 27/05/2022 with BSRBR-RA starting IL-6i or TNFi treatments were included. Occurrence of MI was identified from clinical follow-up forms and through cause of death reported by the national UK death register. Only those MIs occurring whilst the patient was actively receiving drug were included. The risk of MI in patients receiving IL6i compared to TNFi was compared using Cox regression, adjusted for baseline co-variates using propensity scores (PS, see Table 1). Follow-up commenced at the start of the drug of interest and patients were censored at occurrence of MI, death, discontinuation of therapy or last follow-up visit, whichever came first. Multiple imputation was used for missing data. To account for known differences in LoT use of TNFi and IL6i (with IL6i more likely as a later line bDMARD), overall analyses adjusted for LoT in PS and secondary analyses by LoT were conducted. Direct switches between originator to biosimilars were considered the same treatment. Results A total of 29,596 IL6i or TNFi treatments in 20,725 patients were included (3,098 IL-6i; 26,498 TNFi), representing 153,913 person-years of exposure. Compared to patients receiving TNFi, patients starting IL-6i treatment were older, had longer disease duration, less likely to use methotrexate and steroids, and had more comorbidities. During follow-up, 372 MIs occurred, 27 on IL-6i and 345 on TNFi, with an overall lower crude rate of MI in patients receiving IL6i compared to TNFi. After PS adjustment, the risk of MI was not significantly different between the two treatment overall (HR 0.77, 95% CI 0.48-1.24) or when stratified by LoT (Table 1). Conclusion This study could not identify any difference in risk of MI between IL-6i and TNFi treatment after patient characteristics and LoT were considered. Disclosure Z. Tian: None. L. Kearsley-Fleet: None. K. Lauper: Honoraria; Celltrion, Pfizer, Viatris, Galapagos. S. Haughton: None. K. Watson: None. M. Lunt: None. J. Mclaughlin: None. A. Verma: None. K.L. Hyrich: Honoraria; Abbvie. Grants/research support; Pfizer, BMS.
48
Bonaca, M., E. Lesén, E. Giannitsis, et al. "Characteristics and outcomes in patients with a prior myocardial infarction treated with extended dual antiplatelet therapy with ticagrelor 60 mg: findings from ALETHEIA, a multi-country observational study." European Heart Journal - Cardiovascular Pharmacotherapy, August 31, 2023. http://dx.doi.org/10.1093/ehjcvp/pvad062.
Full textAbstract:
Abstract Background Guidelines recommend extended dual antiplatelet therapy (DAPT), including ticagrelor 60 mg twice daily, in high-risk post myocardial infarction (MI) patients who have tolerated 12 months and are not at high bleeding risk. The real-world utilization and bleeding and ischemic outcomes associated with long-term ticagrelor 60 mg in routine clinical practice have not been well described. Methods Register and claims data from US (Optum Clinformatics, IBM MarketScan, Medicare) and Europe (Sweden, Italy, UK, Germany) were extracted. Patients initiating ticagrelor 60 mg ≥ 12 months after MI, meeting eligibility criteria for PEGASUS-TIMI 54 trial, were included. The cumulative incidence of the composite of MI, stroke, or all-cause mortality, and of bleeding requiring hospitalization were calculated. Meta-analyses were performed to combine estimates from each source. Results 7 035 patients treated with ticagrelor 60 mg met eligibility criteria. Median age was 67 years and 29% were females; 12% had a history of multiple MIs. The majority (95%) had been treated with ticagrelor 90 mg prior to initiating ticagrelor 60 mg. At 12 months from initiation of ticagrelor 60 mg, the cumulative incidence (95% CI) of MI, stroke or mortality was 3.33% (2.73–4.04) and was approximately three-fold the risk of bleeding (0.96%; 0.69–1.33). Conclusions This study provides insights into the use of ticagrelor 60 mg in patients with prior MI in clinical practice. Observed event rates for ischemic events and bleeding generally align with those in the pivotal trials, support the established safety profile of ticagrelor, and highlight the significant residual ischemic risk in this population. Clinical Trials.gov Registration NCT04568083
49
"IEEE Quantum Week - Register Today." IEEE Intelligent Systems 38, no. 5 (2023): C2. http://dx.doi.org/10.1109/mis.2023.3311702.
Full text
50
"IEEE Quantum Week - Register Today." IEEE Intelligent Systems 38, no. 4 (2023): C2. http://dx.doi.org/10.1109/mis.2023.3295074.
Full text