Log in

Relevant bibliographies by topics / Mitochondrial Associated Regulatory Factor (Marf) / Journal articles

To see the other types of publications on this topic, follow the link: Mitochondrial Associated Regulatory Factor (Marf).

Journal articles on the topic 'Mitochondrial Associated Regulatory Factor (Marf)'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Mitochondrial Associated Regulatory Factor (Marf).'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Debattisti, Valentina, Diana Pendin, Elena Ziviani, Andrea Daga, and Luca Scorrano. "Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion." Journal of Cell Biology 204, no. 3 (2014): 303–12. http://dx.doi.org/10.1083/jcb.201306121.

Full text

Abstract:

Ablation of the mitochondrial fusion and endoplasmic reticulum (ER)–tethering protein Mfn2 causes ER stress, but whether this is just an epiphenomenon of mitochondrial dysfunction or a contributor to the phenotypes in mitofusin (Mfn)-depleted Drosophila melanogaster is unclear. In this paper, we show that reduction of ER dysfunction ameliorates the functional and developmental defects of flies lacking the single Mfn mitochondrial assembly regulatory factor (Marf). Ubiquitous or neuron- and muscle-specific Marf ablation was lethal, altering mitochondrial and ER morphology and triggering ER stre

APA, Harvard, Vancouver, ISO, and other styles

2

Chen, Yutong, Zhixin Liu, Ning An, et al. "Platelet-Derived Mitochondria Attenuate 5-FU-Induced Injury to Bone-Associated Mesenchymal Stem Cells." Stem Cells International 2023 (January 30, 2023): 1–20. http://dx.doi.org/10.1155/2023/7482546.

Full text

Abstract:

Background. Myelosuppression is a common condition during chemotherapy. Bone-associated mesenchymal stem cells (BA-MSCs) play an essential role in the composition of the hematopoietic microenvironment and support hematopoietic activity. However, chemotherapy-induced damage to BA-MSCs is rarely studied. Recent studies have shown that platelets promote the wound-healing capability of MSCs by mitochondrial transfer. Therefore, this study is aimed at investigating the chemotherapy-induced damage to BA-MSCs and the therapeutic effect of platelet-derived mitochondria. Material/Methods. We establishe

APA, Harvard, Vancouver, ISO, and other styles

3

Morciano, Giampaolo, Carlotta Giorgi, Dario Balestra, et al. "Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death." Molecular Biology of the Cell 27, no. 1 (2016): 20–34. http://dx.doi.org/10.1091/mbc.e15-01-0028.

Full text

Abstract:

The B-cell lymphoma-2 (Bcl-2) family proteins are critical regulators of apoptosis and consist of both proapoptotic and antiapoptotic factors. Within this family, the myeloid cell leukemia factor 1 (Mcl-1) protein exists in two forms as the result of alternative splicing. The long variant (Mcl-1L) acts as an antiapoptotic factor, whereas the short isoform (Mcl-1S) displays proapoptotic activity. In this study, using splice-switching antisense oligonucleotides (ASOs), we increased the synthesis of Mcl-1S, which induced a concurrent reduction of Mcl-1L, resulting in increased sensitivity of canc

APA, Harvard, Vancouver, ISO, and other styles

4

Lin, Ruizhu, and Risto Kerkelä. "Regulatory Mechanisms of Mitochondrial Function and Cardiac Aging." International Journal of Molecular Sciences 21, no. 4 (2020): 1359. http://dx.doi.org/10.3390/ijms21041359.

Full text

Abstract:

Aging is a major risk factor for cardiovascular diseases (CVDs), the major cause of death worldwide. Cardiac myocytes, which hold the most abundant mitochondrial population, are terminally differentiated cells with diminished regenerative capacity in the adult. Cardiomyocyte mitochondrial dysfunction is a characteristic feature of the aging heart and one out of the nine features of cellular aging. Aging and cardiac pathologies are also associated with increased senescence in the heart. However, the cause and consequences of cardiac senescence during aging or in cardiac pathologies are mostly u

APA, Harvard, Vancouver, ISO, and other styles

5

Hwang, Keun Young, and Young Bong Choi. "Modulation of Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1." Journal of Virology 90, no. 1 (2015): 506–20. http://dx.doi.org/10.1128/jvi.01903-15.

Full text

Abstract:

ABSTRACTMitochondrial lipid raft-like microdomains, experimentally also termed mitochondrial detergent-resistant membrane fractions (mDRM), play a role as platforms for recruiting signaling molecules involved in antiviral responses such as apoptosis and innate immunity. Viruses can modulate mitochondrial functions for their own survival and replication. However, viral regulation of the antiviral responses via mDRM remains incompletely understood. Here, we report that human herpesvirus 8 (HHV-8) gene product viral interferon regulatory factor 1 (vIRF-1) is targeted to mDRM during virus replicat

APA, Harvard, Vancouver, ISO, and other styles

6

Laban, Hebatullah, Sophia Siegmund, Maren Zappe, et al. "NFAT5/TonEBP Limits Pulmonary Vascular Resistance in the Hypoxic Lung by Controlling Mitochondrial Reactive Oxygen Species Generation in Arterial Smooth Muscle Cells." Cells 10, no. 12 (2021): 3293. http://dx.doi.org/10.3390/cells10123293.

Full text

Abstract:

Chronic hypoxia increases the resistance of pulmonary arteries by stimulating their contraction and augmenting their coverage by smooth muscle cells (SMCs). While these responses require adjustment of the vascular SMC transcriptome, regulatory elements are not well defined in this context. Here, we explored the functional role of the transcription factor nuclear factor of activated T-cells 5 (NFAT5/TonEBP) in the hypoxic lung. Regulatory functions of NFAT5 were investigated in cultured artery SMCs and lungs from control (Nfat5fl/fl) and SMC-specific Nfat5-deficient (Nfat5(SMC)−/−) mice. Exposu

APA, Harvard, Vancouver, ISO, and other styles

7

Toshima, Takahiro, Mikako Yagi, Yura Do та ін. "Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3β-Srebp2 axis". Life Science Alliance 7, № 7 (2024): e202302423. http://dx.doi.org/10.26508/lsa.202302423.

Full text

Abstract:

Neurodegenerative diseases and other age-related disorders are closely associated with mitochondrial dysfunction. We previously showed that mice with neuron-specific deficiency of mitochondrial translation exhibit leukoencephalopathy because of demyelination. Reduced cholesterol metabolism has been associated with demyelinating diseases of the brain such as Alzheimer’s disease. However, the molecular mechanisms involved and relevance to the pathogenesis remained unknown. In this study, we show that inhibition of mitochondrial translation significantly reduced expression of the cholesterol synt

APA, Harvard, Vancouver, ISO, and other styles

8

D'souza, Donna, Ruanne Y. J. Lai, Michael Shuen, and David A. Hood. "mRNA stability as a function of striated muscle oxidative capacity." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 303, no. 4 (2012): R408—R417. http://dx.doi.org/10.1152/ajpregu.00085.2012.

Full text

Abstract:

A change in mRNA stability alters the abundance of mRNA available for translation and is emerging as a critical pathway influencing gene expression. Variations in the stability of functional and regulatory mitochondrial proteins may contribute to the divergent mitochondrial densities observed in striated muscle. Thus we hypothesized that the stability of mRNAs encoding for regulatory nuclear and mitochondrial transcription factors would be inversely proportional to muscle oxidative capacity and would be facilitated by the activity of RNA binding proteins (RBPs). The stability of mitochondrial

APA, Harvard, Vancouver, ISO, and other styles

9

Wolin, Michael S. "Evidence for novel aspects of Nox4 oxidase regulation of mitochondrial function and peroxide generation in an endothelial cell model of senescence." Biochemical Journal 452, no. 2 (2013): e1-e2. http://dx.doi.org/10.1042/bj20130484.

Full text

Abstract:

Observations by Kozieł et al. reported in this issue of the Biochemical Journal suggest the existence of novel regulatory processes associated with new evidence for increased Nox4 (NAPDH oxidase 4) regulation of mitochondrial function in a cultured endothelial cell aging-induced senescence model. Cellular aging appears to promote a Nox4 interaction with mitochondria that disrupts complex I in the electron transport chain and increases the detection of mitochondrial H2O2. Nox4 appears to maintain a highly interconnected mitochondrial network, which may influence mitochondrial fission and/or fus

APA, Harvard, Vancouver, ISO, and other styles

10

Farge, Géraldine, and Maria Falkenberg. "Organization of DNA in Mammalian Mitochondria." International Journal of Molecular Sciences 20, no. 11 (2019): 2770. http://dx.doi.org/10.3390/ijms20112770.

Full text

Abstract:

As with all organisms that must organize and condense their DNA to fit within the limited volume of a cell or a nucleus, mammalian mitochondrial DNA (mtDNA) is packaged into nucleoprotein structures called nucleoids. In this study, we first introduce the general modes of DNA compaction, especially the role of the nucleoid-associated proteins (NAPs) that structure the bacterial chromosome. We then present the mitochondrial nucleoid and the main factors responsible for packaging of mtDNA: ARS- (autonomously replicating sequence-) binding factor 2 protein (Abf2p) in yeast and mitochondrial transc

APA, Harvard, Vancouver, ISO, and other styles

11

Siekacz, Kamil, Anna Kumor-Kisielewska, Joanna Miłkowska-Dymanowska, et al. "Oxidative Biomarkers Associated with the Pulmonary Manifestation of Post-COVID-19 Complications." Journal of Clinical Medicine 12, no. 13 (2023): 4253. http://dx.doi.org/10.3390/jcm12134253.

Full text

Abstract:

Introduction: The role of mitochondria in post coronavirus disease 2019 (post-COVID-19) complications is unclear, especially in the long-term pulmonary complications. This study aims to investigate the association between post-COVID-19 pulmonary complications and mitochondrial regulatory proteins in the context of oxidative stress. Methodology: Patients who had recovered from COVID-19 were enrolled. According to the evidence of persistent interstitial lung lesions on computed tomography (CT), patients were divided into a long-term pulmonary complications group (P(+)) and a control group withou

APA, Harvard, Vancouver, ISO, and other styles

12

Gordon, Joe W., Arne A. Rungi, Hidetoshi Inagaki, and David A. Hood. "Selected Contribution: Effects of contractile activity on mitochondrial transcription factor A expression in skeletal muscle." Journal of Applied Physiology 90, no. 1 (2001): 389–96. http://dx.doi.org/10.1152/jappl.2001.90.1.389.

Full text

Abstract:

Mitochondrial transcription factor A (Tfam) is a nuclear-encoded gene product that is imported into mitochondria and is required for the transcription of mitochondrial DNA (mtDNA). We hypothesized that conditions known to produce mitochondrial biogenesis in skeletal muscle would be preceded by an increase in Tfam expression. Therefore, rat muscle was stimulated (10 Hz, 3 h/day). Tfam mRNA levels were significantly elevated (by 55%) at 4 days and returned to control levels at 14 days. Tfam import into intermyofibrillar (IMF) mitochondria was increased by 52 and 61% ( P < 0.05) at 5 and 7 day

APA, Harvard, Vancouver, ISO, and other styles

13

Inguscio, Chiara Rita, Elisa Dalla Pozza, Ilaria Dando, et al. "Mitochondrial Features of Mouse Myoblasts Are Finely Tuned by Low Doses of Ozone: The Evidence In Vitro." International Journal of Molecular Sciences 24, no. 10 (2023): 8900. http://dx.doi.org/10.3390/ijms24108900.

Full text

Abstract:

The mild oxidative stress induced by low doses of gaseous ozone (O3) activates the antioxidant cell response through the nuclear factor erythroid 2-related factor 2 (Nrf2), thus inducing beneficial effects without cell damage. Mitochondria are sensitive to mild oxidative stress and represent a susceptible O3 target. In this in vitro study, we investigated the mitochondrial response to low O3 doses in the immortalized, non-tumoral muscle C2C12 cells; a multimodal approach including fluorescence microscopy, transmission electron microscopy and biochemistry was used. Results demonstrated that mit

APA, Harvard, Vancouver, ISO, and other styles

14

Kobayashi, Masaki, Seira Uta, Minami Otsubo та ін. "Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes—Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue". Nutrients 12, № 7 (2020): 2054. http://dx.doi.org/10.3390/nu12072054.

Full text

Abstract:

Caloric restriction (CR) improves whole body metabolism, suppresses age-related pathophysiology, and extends lifespan in rodents. Metabolic remodeling, including fatty acid (FA) biosynthesis and mitochondrial biogenesis, in white adipose tissue (WAT) plays an important role in the beneficial effects of CR. We have proposed that CR-induced mitochondrial biogenesis in WAT is mediated by peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), which is transcriptionally regulated by sterol regulatory element-binding protein 1c (SREBP-1c), a master regulator of FA biosynthesis. We hav

APA, Harvard, Vancouver, ISO, and other styles

15

Koval, Olha M., Emily K. Nguyen, Velarchana Santhana, et al. "Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation." Science Signaling 12, no. 579 (2019): eaav1439. http://dx.doi.org/10.1126/scisignal.aav1439.

Full text

Abstract:

The role of the mitochondrial Ca2+uniporter (MCU) in physiologic cell proliferation remains to be defined. Here, we demonstrated that the MCU was required to match mitochondrial function to metabolic demands during the cell cycle. During the G1-S transition (the cycle phase with the highest mitochondrial ATP output), mitochondrial fusion, oxygen consumption, and Ca2+uptake increased in wild-type cells but not in cells lacking MCU. In proliferating wild-type control cells, the addition of the growth factors promoted the activation of the Ca2+/calmodulin-dependent kinase II (CaMKII) and the phos

APA, Harvard, Vancouver, ISO, and other styles

16

Li, Min, Li Chen, Aziz Khan, et al. "Transcriptome and MiRNAomics Analyses Identify Genes Associated with Cytoplasmic Male Sterility in Cotton (Gossypium hirsutum L.)." International Journal of Molecular Sciences 22, no. 9 (2021): 4684. http://dx.doi.org/10.3390/ijms22094684.

Full text

Abstract:

Cytoplasmic male sterility (CMS) is important for large-scale hybrid seed production. Rearrangements in the mitochondrial DNA (mtDNA) for the cotton (Gossypium hirsutum L.) CMS line J4A were responsible for pollen abortion. However, the expression patterns of nuclear genes associated with pollen abortion and the molecular basis of CMS for J4A are unknown, and were the objectives of this study by comparing J4A with the J4B maintainer line. Cytological evaluation of J4A anthers showed that microspore abortion occurs during meiosis preventing pollen development. Changes in enzyme activity of mito

APA, Harvard, Vancouver, ISO, and other styles

17

He, Feng, Xiaoli Ru, and Tao Wen. "NRF2, a Transcription Factor for Stress Response and Beyond." International Journal of Molecular Sciences 21, no. 13 (2020): 4777. http://dx.doi.org/10.3390/ijms21134777.

Full text

Abstract:

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification. NRF2 activation renders cells resistant to chemical carcinogens and inflammatory challenges. In addition to antioxidant responses, NRF2 is involved in many other cellular processes, including metabolism and inflammation, and its functions are beyond the originally envisioned. NRF2 activity is tightly regulated through a complex transcriptional and post-t

APA, Harvard, Vancouver, ISO, and other styles

18

Pokkunuri, Indira D., Mustafa F. Lokhandwala, and Anees Ahmad Banday. "Protein disulfide isomerase inhibition impairs Keap1/Nrf2 signaling and mitochondrial function and induces apoptosis in renal proximal tubular cells." American Journal of Physiology-Renal Physiology 319, no. 4 (2020): F686—F696. http://dx.doi.org/10.1152/ajprenal.00049.2020.

Full text

Abstract:

Renal proximal tubular apoptosis plays a critical role in kidney health and disease. However, cellular molecules that trigger renal apoptosis remain elusive. Here, we evaluated the effect of inhibiting protein disulfide isomerase (PDI), a critical thioredoxin chaperone protein, on apoptosis as well as the underlying mechanisms in human renal proximal tubular (HK2) cells. HK2 cells were transfected with PDI-specific siRNA in the absence and presence of an antioxidant, tempol. PDI siRNA transfection resulted in a decrease of ~70% in PDI protein expression and enzyme activity. PDI inhibition incr

APA, Harvard, Vancouver, ISO, and other styles

19

Ma, Sai, Jing Feng, Ran Zhang, et al. "SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–15. http://dx.doi.org/10.1155/2017/4602715.

Full text

Abstract:

Background. Diabetic cardiomyopathy (DCM) is a major threat for diabetic patients. Silent information regulator 1 (SIRT1) has a regulatory effect on mitochondrial dynamics, which is associated with DCM pathological changes. Our study aims to investigate whether resveratrol, a SRIT1 activator, could exert a protective effect against DCM. Methods and Results. Cardiac-specific SIRT1 knockout (SIRT1KO) mice were generated using Cre-loxP system. SIRT1KO mice displayed symptoms of DCM, including cardiac hypertrophy and dysfunction, insulin resistance, and abnormal glucose metabolism. DCM and SIRT1KO

APA, Harvard, Vancouver, ISO, and other styles

20

Aerbajinai, Wulin, Manik C. Ghosh, Jie Liu та ін. "Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS". Blood Advances 3, № 8 (2019): 1211–25. http://dx.doi.org/10.1182/bloodadvances.2018026070.

Full text

Abstract:

Abstract In macrophages, cellular iron metabolism status is tightly integrated with macrophage phenotype and associated with mitochondrial function. However, how molecular events regulate mitochondrial activity to integrate regulation of iron metabolism and macrophage phenotype remains unclear. Here, we explored the important role of the actin-regulatory protein glia maturation factor-γ (GMFG) in the regulation of cellular iron metabolism and macrophage phenotype. We found that GMFG was downregulated in murine macrophages by exposure to iron and hydrogen peroxide. GMFG knockdown altered the ex

APA, Harvard, Vancouver, ISO, and other styles

21

Watson, Peter A., Nicholas Birdsey, Gordon S. Huggins, Eric Svensson, Daniel Heppe, and Leslie Knaub. "Cardiac-specific overexpression of dominant-negative CREB leads to increased mortality and mitochondrial dysfunction in female mice." American Journal of Physiology-Heart and Circulatory Physiology 299, no. 6 (2010): H2056—H2068. http://dx.doi.org/10.1152/ajpheart.00394.2010.

Full text

Abstract:

Cardiac failure is associated with diminished activation of the transcription factor cyclic nucleotide regulatory element binding-protein (CREB), and heart-specific expression of a phosphorylation-deficient CREB mutant in transgenic mice [dominant negative CREB (dnCREB) mice] recapitulates the contractile phenotypes of cardiac failure (Fentzke RC, Korcarz CE, Lang RM, Lin H, Leiden JM. Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart. J Clin Invest 101: 2415–2426, 1998). In the present study, we demonstrated significantly elevated

APA, Harvard, Vancouver, ISO, and other styles

22

Nakayama, Hiroyuki, and Kinya Otsu. "Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases." Biochemical Journal 475, no. 5 (2018): 839–52. http://dx.doi.org/10.1042/bcj20170714.

Full text

Abstract:

Mitochondria play a central role in multiple cellular functions, including energy production, calcium homeostasis, and cell death. Currently, growing evidence indicates the vital roles of mitochondria in triggering and maintaining inflammation. Chronic inflammation without microbial infection — termed sterile inflammation — is strongly involved in the development of heart failure. Sterile inflammation is triggered by the activation of pattern recognition receptors (PRRs) that sense endogenous ligands called damage-associated molecular patterns (DAMPs). Mitochondria release multiple DAMPs inclu

APA, Harvard, Vancouver, ISO, and other styles

23

Gil-Varea, Elia, Maria Fedetz, Herena Eixarch, et al. "A New Risk Variant for Multiple Sclerosis at 11q23.3 Locus Is Associated with Expansion of CXCR5+ Circulating Regulatory T Cells." Journal of Clinical Medicine 9, no. 3 (2020): 625. http://dx.doi.org/10.3390/jcm9030625.

Full text

Abstract:

Genome-wide association studies and meta-analysis have contributed to the identification of more than 200 loci associated with multiple sclerosis (MS). However, a proportion of MS heritability remains unknown. We aimed to uncover new genetic variants associated with MS and determine their functional effects. For this, we resequenced the exons and regulatory sequences of 14 MS risk genes in a cohort of MS patients and healthy individuals (n = 1070) and attempted to validate a selection of signals through genotyping in an independent cohort (n = 5138). We identified three new MS-associated varia

APA, Harvard, Vancouver, ISO, and other styles

24

Tang, Qing-Qing, Zu-Ding Wang, Xiao-Hong An, et al. "Apigenin Ameliorates H2O2-Induced Oxidative Damage in Melanocytes through Nuclear Factor-E2-Related Factor 2 (Nrf2) and Phosphatidylinositol 3-Kinase (PI3K)/Protein Kinase B (Akt)/Mammalian Target of Rapamycin (mTOR) Pathways and Reducing the Generation of Reactive Oxygen Species (ROS) in Zebrafish." Pharmaceuticals 17, no. 10 (2024): 1302. http://dx.doi.org/10.3390/ph17101302.

Full text

Abstract:

Background: Apigenin is one of the natural flavonoids found mainly in natural plants, as well as some fruits and vegetables, with celery in particular being the most abundant. Apigenin has antioxidant, anti-tumor, anti-inflammatory, and anticancer effects. In this research, we attempted to further investigate the effects of apigenin on the mechanism of repairing oxidative cell damage. The present study hopes to provide a potential candidate for abnormal skin pigmentation disorders. Methods: We used 0.4 mM H2O2 to treat B16F10 cells for 12 h to establish a model of oxidative stress in melanocyt

APA, Harvard, Vancouver, ISO, and other styles

25

Gleyzer, Natalie, Kristel Vercauteren, and Richard C. Scarpulla. "Control of Mitochondrial Transcription Specificity Factors (TFB1M and TFB2M) by Nuclear Respiratory Factors (NRF-1 and NRF-2) and PGC-1 Family Coactivators." Molecular and Cellular Biology 25, no. 4 (2005): 1354–66. http://dx.doi.org/10.1128/mcb.25.4.1354-1366.2005.

Full text

Abstract:

ABSTRACT In vertebrates, mitochondrial DNA (mtDNA) transcription is initiated bidirectionally from closely spaced promoters, HSP and LSP, within the D-loop regulatory region. Early studies demonstrated that mtDNA transcription requires mitochondrial RNA polymerase and Tfam, a DNA binding stimulatory factor that is required for mtDNA maintenance. Recently, mitochondrial transcription specificity factors (TFB1M and TFB2M), which markedly enhance mtDNA transcription in the presence of Tfam and mitochondrial RNA polymerase, have been identified in mammalian cells. Here, we establish that the expre

APA, Harvard, Vancouver, ISO, and other styles

26

Li, Chaoran, Pulavendran Sivasami, Cody Elkins, et al. "Obesity-induced dysregulation of a unique subset of Tregs promotes skin inflammation." Journal of Immunology 210, no. 1_Supplement (2023): 248.02. http://dx.doi.org/10.4049/jimmunol.210.supp.248.02.

Full text

Abstract:

Abstract Obesity is associated with increased skin inflammation and is a major risk factor for psoriasis, raising the question of how obesity disrupts the regulatory mechanisms that keep skin inflammation in check at steady state. We found that skin was enriched with a unique subset of CD4 +Foxp3 +regulatory T cells (Tregs), which is critical to limit IL-17A-mediated psoriatic inflammation. Diet-induced obesity, however, resulted in a significant reduction of this subset of skin Tregs and a corresponding loss of control over IL-17A-mediated inflammation. Mechanistically, this specific skin Tre

APA, Harvard, Vancouver, ISO, and other styles

27

Yang, Ziqiang, Wei Cheng, Lixin Hong, et al. "Adenine Nucleotide (ADP/ATP) Translocase 3 Participates in the Tumor Necrosis Factor–induced Apoptosis of MCF-7 Cells." Molecular Biology of the Cell 18, no. 11 (2007): 4681–89. http://dx.doi.org/10.1091/mbc.e06-12-1161.

Full text

Abstract:

Mitochondrial adenine nucleotide translocase (ANT) is believed to be a component or a regulatory component of the mitochondrial permeability transition pore (mtPTP), which controls mitochondrial permeability transition during apoptosis. However, the role of ANT in apoptosis is still uncertain, because hepatocytes isolated from ANT knockout and wild-type mice are equally sensitive to TNF- and Fas-induced apoptosis. In a screen for genes required for tumor necrosis factor α (TNF-α)-induced apoptosis in MCF-7 human breast cancer cells using retrovirus insertion–mediated random mutagenesis, we dis

APA, Harvard, Vancouver, ISO, and other styles

28

Ziegelhöffer, Attila, Iveta Waczulíková, Miroslav Ferko, et al. "Calcium signaling-mediated endogenous protection of cell energetics in the acutely diabetic myocardiumThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research." Canadian Journal of Physiology and Pharmacology 87, no. 12 (2009): 1083–94. http://dx.doi.org/10.1139/y09-108.

Full text

Abstract:

In acute diabetic myocardium, calcium signals propagated by intracellular calcium transients participate in the protection of cell energetics via upregulating the formation of mitochondrial energy transition pores (ETP). Mechanisms coupling ETP formation with an increase in membrane fluidity and a decrease in transmembrane potential of the mitochondria are discussed. Our results indicate that the amplification of calcium transients in the diabetic heart is associated with an increase in their amplitude. Moreover, the signals transferred by calcium transients also regulated ETP formation in non

APA, Harvard, Vancouver, ISO, and other styles

29

Chen, Guan-Yu, Yu-Chieh Shu, Duen-Yau Chuang, and Yuan-Chuen Wang. "Inflammatory and Apoptotic Regulatory Activity of Tanshinone IIA in Helicobacter pylori-Infected Cells." American Journal of Chinese Medicine 44, no. 06 (2016): 1187–206. http://dx.doi.org/10.1142/s0192415x1650066x.

Full text

Abstract:

Helicobacter pylori infections induce host cell inflammation and apoptosis, however, they are conflicting. Tanshinone IIA is an active compound of Salvia miltiorrhiza Bge. In this study, we investigated the regulatory effects of tanshinone IIA on H. pylori-induced inflammation and apoptosis in vitro. Tanshinone IIA treatments (13.6–54.4[Formula: see text][Formula: see text]M) significantly decreased nuclear factor kappa B (NF-kB) and mitogen-activated protein kinase (MAPK) [p-38 and C-terminal Jun-kinase 1/2 (JNK1/2)] protein expressions and inflammatory substance [cyclooxygenase-2 (COX-2), 5-

APA, Harvard, Vancouver, ISO, and other styles

30

Niazi, Adnan Khan, Etienne Delannoy, Rana Khalid Iqbal, et al. "Mitochondrial Transcriptome Control and Intercompartment Cross-Talk During Plant Development." Cells 8, no. 6 (2019): 583. http://dx.doi.org/10.3390/cells8060583.

Full text

Abstract:

We address here organellar genetic regulation and intercompartment genome coordination. We developed earlier a strategy relying on a tRNA-like shuttle to mediate import of nuclear transgene-encoded custom RNAs into mitochondria in plants. In the present work, we used this strategy to drive trans-cleaving hammerhead ribozymes into the organelles, to knock down specific mitochondrial RNAs and analyze the regulatory impact. In a similar approach, the tRNA mimic was used to import into mitochondria in Arabidopsis thaliana the orf77, an RNA associated with cytoplasmic male sterility in maize and po

APA, Harvard, Vancouver, ISO, and other styles

31

Tulen, Christy B. M., Antoon Opperhuizen, Frederik-Jan van Schooten, and Alexander H. V. Remels. "Disruption of the Molecular Regulation of Mitochondrial Metabolism in Airway and Lung Epithelial Cells by Cigarette Smoke: Are Aldehydes the Culprit?" Cells 12, no. 2 (2023): 299. http://dx.doi.org/10.3390/cells12020299.

Full text

Abstract:

Chronic obstructive pulmonary disease (COPD) is a devastating lung disease for which cigarette smoking is the main risk factor. Acetaldehyde, acrolein, and formaldehyde are short-chain aldehydes known to be formed during pyrolysis and combustion of tobacco and have been linked to respiratory toxicity. Mitochondrial dysfunction is suggested to be mechanistically and causally involved in the pathogenesis of smoking-associated lung diseases such as COPD. Cigarette smoke (CS) has been shown to impair the molecular regulation of mitochondrial metabolism and content in epithelial cells of the airway

APA, Harvard, Vancouver, ISO, and other styles

32

Chou, Chih-Wei, Xi Tan, Chia-Nung Hung, et al. "Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism." Cancers 12, no. 9 (2020): 2715. http://dx.doi.org/10.3390/cancers12092715.

Full text

Abstract:

The interplay between glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) is central to maintain energy homeostasis. It remains to be determined whether there is a mechanism governing metabolic fluxes based on substrate availability in microenvironments. Here we show that menin is a key transcription factor regulating the expression of OXPHOS and glycolytic genes in cancer cells and primary tumors with poor prognosis. A group of menin-associated proteins (MAPs), including KMT2A, MED12, WAPL, and GATA3, is found to restrain menin’s full function in this transcription regulation. shR

APA, Harvard, Vancouver, ISO, and other styles

33

Paulmann, Dajana, Thomas Magulski, Rebecca Schwarz, et al. "Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation." Journal of General Virology 89, no. 7 (2008): 1593–604. http://dx.doi.org/10.1099/vir.0.83521-0.

Full text

Abstract:

Hepatitis A virus (HAV) antagonizes the innate immune response by inhibition of retinoic acid-inducible gene I-mediated and melanoma differentiation-associated gene 5-mediated beta interferon (IFN-β) gene expression. This study showed that this is due to an interaction of HAV with mitochondrial antiviral signalling protein (MAVS)-dependent signalling, in which the viral non-structural protein 2B and the protein intermediate 3ABC recently suggested in this context seem to be involved, cooperatively affecting the activities of MAVS and the kinases TANK-binding kinase 1 (TBK1) and the inhibitor o

APA, Harvard, Vancouver, ISO, and other styles

34

Wang, Yani, Xiang Peng, Maomao Zhang, Ying Jia, Bo Yu, and Jinwei Tian. "Revisiting Tumors and the Cardiovascular System: Mechanistic Intersections and Divergences in Ferroptosis." Oxidative Medicine and Cellular Longevity 2020 (August 18, 2020): 1–13. http://dx.doi.org/10.1155/2020/9738143.

Full text

Abstract:

Ferroptosis was recently identified as an iron-dependent regulatory necrosis process mediated by polyunsaturated fatty acid (PUFA) peroxidation. The pivotal events related to oxidative stress in ferroptosis include direct or indirect glutathione peroxidase 4 (GPX4) inhibition, ferrous iron overload, and lipid peroxidation. The links between ferroptosis and multiple pathological processes including tumor and cardiovascular system disease have become increasingly apparent, and the mechanisms and compounds involved in ferroptosis, such as reduction of coenzyme Q10 (ubiquinone/CoQ10), are graduall

APA, Harvard, Vancouver, ISO, and other styles

35

Yang, Minghui, Shengyu Guan, Jingli Tao, et al. "Melatonin promotes male reproductive performance and increases testosterone synthesis in mammalian Leydig cells." Biology of Reproduction 104, no. 6 (2021): 1322–36. http://dx.doi.org/10.1093/biolre/ioab046.

Full text

Abstract:

Abstract Leydig cells play a critical role in male reproductive physiology, and their dysfunction is usually associated with male infertility. Melatonin has an important protective and regulatory role in these cells. However, the lack of suitable animal models impedes us from addressing the impact of endogenous melatonin on these cells. In the current study, by using arylalkylamine N-acetyltransferase (AANAT) overexpression transgenic sheep and AANAT knockout mice, we confirmed the regulatory effects of endogenously occurring melatonin on Leydig cells as well as its beneficial effects on male

APA, Harvard, Vancouver, ISO, and other styles

36

Christian, Patricia, and Qiaozhu Su. "MicroRNA regulation of mitochondrial and ER stress signaling pathways: implications for lipoprotein metabolism in metabolic syndrome." American Journal of Physiology-Endocrinology and Metabolism 307, no. 9 (2014): E729—E737. http://dx.doi.org/10.1152/ajpendo.00194.2014.

Full text

Abstract:

The development of metabolic syndrome is closely associated with the deregulation of lipid metabolism. Emerging evidence has demonstrated that microRNAs (miRNAs) are intensively engaged in lipid and lipoprotein metabolism by regulating genes involved in control of intracellular lipid synthesis, mitochondrial fatty acid oxidation, and lipoprotein assembly. Mitochondrial dysfunction induced by altered miRNA expression has been proposed to be a contributing factor in the onset of metabolic diseases, while at the same time, aberrant expression of certain miRNAs is associated with the induction of

APA, Harvard, Vancouver, ISO, and other styles

37

Kim, Min Ji, Pascale Leclercq, Emilie Lanoy, et al. "A 6-Month Interruption of Antiretroviral Therapy Improves Adipose Tissue Function in HIV-Infected Patients: The ANRS EP29 Lipostop Study." Antiviral Therapy 12, no. 8 (2007): 1273–84. http://dx.doi.org/10.1177/135965350701200809.

Full text

Abstract:

Objective To examine the reversibility of adipose tissue alterations in HIV-infected patients after a 6-month interruption of antiretroviral therapy (ART). Methods Forty HIV-infected patients on stable effective ART were enrolled, 33 of them completed the study. Patients underwent a physical examination, laboratory tests and needle biopsy of subcutaneous abdominal adipose tissue both at inclusion and at month 6. Changes in fat morphology, mitochondrial DNA (mtDNA) content and gene expression were examined in 29, 23 and 20 patients, respectively. Results Body fat distribution was not clearly mo

APA, Harvard, Vancouver, ISO, and other styles

38

Tang, Eric D., and Cun-Yu Wang. "MAVS Self-Association Mediates Antiviral Innate Immune Signaling." Journal of Virology 83, no. 8 (2009): 3420–28. http://dx.doi.org/10.1128/jvi.02623-08.

Full text

Abstract:

ABSTRACT The innate immune system recognizes nucleic acids during viral infection and stimulates cellular antiviral responses. Intracellular detection of RNA virus infection is mediated by the RNA helicases RIG-I (retinoic acid inducible gene I) and MDA-5, which recognize viral RNA and signal through the adaptor molecule MAVS (mitochondrial antiviral signaling) to stimulate the phosphorylation and activation of the transcription factors IRF3 (interferon regulatory factor 3) and IRF7. Once activated, IRF3 and IRF7 turn on the expression of type I interferons, such as beta interferon. Interestin

APA, Harvard, Vancouver, ISO, and other styles

39

Peng, Xiandong, Min Yu, and Jiazhou Chen. "Transcriptome sequencing identifies genes associated with invasion of ovarian cancer." Journal of International Medical Research 48, no. 9 (2020): 030006052095091. http://dx.doi.org/10.1177/0300060520950912.

Full text

Abstract:

Objective To identify key genes in ovarian cancer using transcriptome sequencing in two cell lines: MCV152 (benign ovarian epithelial tumour) and SKOV-3 (ovarian serous carcinoma). Methods Differentially expressed genes (DEGs) between SKOV-3 and MCV152 were identified. Candidate genes were assessed for enrichment in gene ontology function and Kyoto Encyclopaedia of Genes and Genomes pathway. Candidate gene expression in SKOV-3 and MCV152 cells was validated using Western blots. Results A total of 2020 upregulated and 1673 downregulated DEGs between SKOV3 and MCV152 cells were identified that w

APA, Harvard, Vancouver, ISO, and other styles

40

Paul, Sanjoy, Jennifer A. Schmidt, and W. Scott Moye-Rowley. "Regulation of the CgPdr1 Transcription Factor from the Pathogen Candida glabrata." Eukaryotic Cell 10, no. 2 (2010): 187–97. http://dx.doi.org/10.1128/ec.00277-10.

Full text

Abstract:

ABSTRACTCandida glabratais an opportunistic human pathogen that is increasingly associated with candidemia, owing in part to the intrinsic and acquired high tolerance the organism exhibits for the important clinical antifungal drug fluconazole. This elevated fluconazole resistance often develops through gain-of-function mutations in the zinc cluster-containing transcriptional regulatorC. glabrataPdr1 (CgPdr1). CgPdr1 induces the expression of an ATP-binding cassette (ABC) transporter-encoding gene, CgCDR1.Saccharomyces cerevisiaehas two CgPdr1 homologues called ScPdr1 and ScPdr3. These factors

APA, Harvard, Vancouver, ISO, and other styles

41

Yastani, Deasyka, and Sri Widia A. Jusman. "The role of Nrf2 transcription factors in various physiological and pathological states." Acta Biochimica Indonesiana 6, no. 2 (2024): 103. http://dx.doi.org/10.32889/actabioina.103.

Full text

Abstract:

Since its first report in 1994, understanding of the nuclear factor erythroid 2-related factor 2 (Nrf2) has continued to grow. Initially recognized for its role in cellular response to oxidative stress, Nrf2 is now known to be involved in a variety of regulatory process, including metabolic regulation, autophagy, protein homeostasis (proteostasis), and mitochondrial biogenesis. The expression of Nrf2 target genes is highly dependent on stimulus activation and interactions with transcription factors, activators, and repressors. Nrf2 activation serves as a defense mechanism under physiological c

APA, Harvard, Vancouver, ISO, and other styles

42

Leinheiser, Anna K., Colleen C. Mitchell, Ethan Rooke, Stefan Strack, and Chad E. Grueter. "A dynamical systems model for the total fission rate in Drp1-dependent mitochondrial fission." PLOS Computational Biology 20, no. 11 (2024): e1012596. http://dx.doi.org/10.1371/journal.pcbi.1012596.

Full text

Abstract:

Mitochondrial hyperfission in response to cellular insult is associated with reduced energy production and programmed cell death. Thus, there is a critical need to understand the molecular mechanisms coordinating and regulating the complex process of mitochondrial fission. We develop a nonlinear dynamical systems model of dynamin related protein one (Drp1)-dependent mitochondrial fission and use it to identify parameters which can regulate the total fission rate (TFR) as a function of time. The TFR defined from a nondimensionalization of the model undergoes a Hopf bifurcation with bifurcation

APA, Harvard, Vancouver, ISO, and other styles

43

McAdams, Natalie M., Michelle L. Ammerman, Julee Nanduri, Kaylen Lott, John C. Fisk, and Laurie K. Read. "An Arginine-Glycine-Rich RNA Binding Protein Impacts the Abundance of Specific mRNAs in the Mitochondria of Trypanosoma brucei." Eukaryotic Cell 14, no. 2 (2014): 149–57. http://dx.doi.org/10.1128/ec.00232-14.

Full text

Abstract:

ABSTRACT In kinetoplastid parasites, regulation of mitochondrial gene expression occurs posttranscriptionally via RNA stability and RNA editing. In addition to the 20S editosome that contains the enzymes required for RNA editing, a dynamic complex called the mitochondrial RNA binding 1 (MRB1) complex is also essential for editing. Trypanosoma brucei RGG3 (TbRGG3) was originally identified through its interaction with the guide RNA-associated proteins 1 and 2 (GAP1/2), components of the MRB1 complex. Both the arginine-glycine-rich character of TbRGG3, which suggests a function in RNA binding, a

APA, Harvard, Vancouver, ISO, and other styles

44

He, Fang, Jie-Qiong Jin, Qing-Qing Qin та ін. "Resistin Regulates Fatty Acid Β Oxidation by Suppressing Expression of Peroxisome Proliferator Activator Receptor Gamma-Coactivator 1α (PGC-1α)". Cellular Physiology and Biochemistry 46, № 5 (2018): 2165–72. http://dx.doi.org/10.1159/000489546.

Full text

Abstract:

Background/Aims: Abnormal fatty acid β oxidation has been associated with obesity and type 2 diabetes. Resistin is an adipokine that has been considered as a potential factor in obesity-mediated insulin resistance and type 2 diabetes. However, the effect of resistin on fatty acid β oxidation needs to be elucidated. Methods: We detected the effects of resistin on the expression of fatty acid oxidation (FAO) transcriptional regulatory genes, the fatty acid transport gene, and mitochondrial β-oxidation genes using real-time PCR. The rate of FAO was measured using 14C-palmitate. Immunofluorescence

APA, Harvard, Vancouver, ISO, and other styles

45

Prasad, Manoj, Anna N. Walker, Jasmeet Kaur, et al. "Endoplasmic Reticulum Stress Enhances Mitochondrial Metabolic Activity in Mammalian Adrenals and Gonads." Molecular and Cellular Biology 36, no. 24 (2016): 3058–74. http://dx.doi.org/10.1128/mcb.00411-16.

Full text

Abstract:

The acute response to stress consists of a series of physiological programs to promote survival by generating glucocorticoids and activating stress response genes that increase the synthesis of many chaperone proteins specific to individual organelles. In the endoplasmic reticulum (ER), short-term stress triggers activation of the unfolded protein response (UPR) module that either leads to neutralization of the initial stress or adaptation to it; chronic stress favors cell death. UPR induces expression of the transcription factor, C/EBP homology protein (CHOP), and its deletion protects agains

APA, Harvard, Vancouver, ISO, and other styles

46

Aranda-Rivera, Ana Karina, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, et al. "Sulforaphane Protects against Unilateral Ureteral Obstruction-Induced Renal Damage in Rats by Alleviating Mitochondrial and Lipid Metabolism Impairment." Antioxidants 11, no. 10 (2022): 1854. http://dx.doi.org/10.3390/antiox11101854.

Full text

Abstract:

Unilateral ureteral obstruction (UUO) is an animal rodent model that allows the study of obstructive nephropathy in an accelerated manner. During UUO, tubular damage is induced, and alterations such as oxidative stress, inflammation, lipid metabolism, and mitochondrial impairment favor fibrosis development, leading to chronic kidney disease progression. Sulforaphane (SFN), an isothiocyanate derived from green cruciferous vegetables, might improve mitochondrial functions and lipid metabolism; however, its role in UUO has been poorly explored. Therefore, we aimed to determine the protective effe

APA, Harvard, Vancouver, ISO, and other styles

47

Chong, Zhao Zhong, Shi-Hua Lin, and Kenneth Maiese. "The NAD+ Precursor Nicotinamide Governs Neuronal Survival During Oxidative Stress Through Protein Kinase B Coupled to FOXO3a and Mitochondrial Membrane Potential." Journal of Cerebral Blood Flow & Metabolism 24, no. 7 (2004): 728–43. http://dx.doi.org/10.1097/01.wcb.0000122746.72175.0e.

Full text

Abstract:

Nicotinamide, a ß-nicotinamide adenine dinucleotide (NAD+) precursor and an essential nutrient for cell growth and function, may offer critical insights into the specific cellular mechanisms that determine neuronal survival, since this agent significantly impacts upon both neuronal and vascular integrity in the central nervous system. The authors show that nicotinamide provides broad, but concentration-specific, protection against apoptotic genomic DNA fragmentation and membrane phosphatidylserine exposure during oxidative stress to secure cellular integrity and prevent phagocytic cellular dem

APA, Harvard, Vancouver, ISO, and other styles

48

Sheng, Junqin, Hongyan Li, Qin Dai, et al. "NR4A1 Promotes Diabetic Nephropathy by Activating Mff-Mediated Mitochondrial Fission and Suppressing Parkin-Mediated Mitophagy." Cellular Physiology and Biochemistry 48, no. 4 (2018): 1675–93. http://dx.doi.org/10.1159/000492292.

Full text

Abstract:

Background/Aims: Disrupted mitochondrial dynamics, including excessive mitochondrial fission and mitophagy arrest, has been identified as a pathogenic factor in diabetic nephropathy (DN), although the upstream regulatory signal for mitochondrial fission activation and mitophagy arrest in the setting of DN remains unknown. Methods: Wild-type (WT) mice and NR4A1 knockout (NR4A1-KO) mice were used to establish a DN model. Mitochondrial fission and mitophagy were evaluated by western blotting and immunofluorescence. Mitochondrial function was assessed by JC-1 staining, the mPTP opening assay, immu

APA, Harvard, Vancouver, ISO, and other styles

49

Liu, Xin, Yuannyu Zhang, Feng Zhou, et al. "Quantitative Proteomic and Transcriptomic Analysis Reveals Post-Transcriptional Regulation of Mitochondrial Biogenesis during Erythropoiesis." Blood 126, no. 23 (2015): 47. http://dx.doi.org/10.1182/blood.v126.23.47.47.

Full text

Abstract:

Abstract The differentiation and maturation of erythroid cells require highly regulated patterns of gene expression and metabolism. Mitochondria are critical for heme biosynthesis and iron metabolism in erythroid cells, yet their regulation during normal erythroid maturation remains largely unexplored. Here we measured global protein and mRNA expression in primary human fetal liver and adult bone marrow-derived CD34+ hematopoietic stem/progenitor cells (HSPCs) and differentiated erythroid precursors (proerythroblasts or ProEs) by mass-spectrometry-based quantitative proteomics and RNA-seq anal

APA, Harvard, Vancouver, ISO, and other styles

50

Porter, Kim Maria Frances, Iain Parry Hargreaves, Stephen De Souza, and Rebecca Goddard. "Treatment with the direct oral anticoagulants (DOACs) apixaban and rivaroxaban associated with significant worsening of behavioural and psychological symptoms of dementia (BPSD)." BMJ Case Reports 14, no. 3 (2021): e240059. http://dx.doi.org/10.1136/bcr-2020-240059.

Full text

Abstract:

We report the cases of two patients who developed worsening behavioural and psychological symptoms of dementia (BPSD), coinciding with starting the factor Xa inhibitor direct oral anticoagulant medications apixaban and rivaroxaban, respectively. Both patients required detaining under the Mental Health Act. Their symptoms improved significantly, within 2 weeks, on switching to alternative anticoagulant therapies and they were both discharged from the acute psychiatric ward. Front-line staff should partake in postmarketing surveillance of medications, completing the Medicines and Healthcare prod

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!