Academic literature on the topic 'Mitochondrial biogenesis and quality control'

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Dissertations / Theses on the topic "Mitochondrial biogenesis and quality control"

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Jong, Liesbeth de. "Regulated assembly of the respiratory chain in Saccharomyces cerevisiae involvement of the mitochondrial NAD-linked isocitrate dehydrogenase, (AAA-)metallo-proteases and prohibitin in synthesis, quality control, turnover and stability /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/87355.

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Leung, Eileen. "Quality control in the biogenesis of the signal recognition particle." Thesis, University of Newcastle upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506530.

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Ostojic, Jelena. "Control of the biogenesis of the OXPHOS complexes and their interactions in Saccharomyces cerevisiae." Thesis, Evry-Val d'Essonne, 2013. http://www.theses.fr/2013EVRY0013/document.

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Le complexe III de la chaine respiratoire mitochondriale (OXPHOS III) chez S. cerevisiae est assemblé à partir de dix sous-unités structurales codées par le génome soit nucléaire, soit mitochondrial et fait intervenir une douzaine de protéines extrinsèques au complexe. Nous avons étudié l’une d’entre elle, Bcs1, une ATPase oligomérique conservée de la famille des protéines AAA (ATPases Associated with diverse cellular Activities), qui contrôle la dernière étape de l’assemblage du complexe III. Chez l’Homme, des mutations dans l’orthologue de BCS1, BCS1L, sont associées à différentes maladies.
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MacVicar, Thomas D. B. "Autophagy and mitochondrial quality control in homeostasis and disease." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627943.

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Mitochondria are the powerhouses of eukaryotic cells and they must remain healthy in order to generate sufficient ATP for cellular function. Dysfunctional mitochondria pose a grave threat to high-energy demanding tissues and are associated with an array of human diseases. Mitochondria exist in a dynamic organelle network that is essential for their intracellular distribution and quality control. A damaged mitochondrion must first be exiled from the network by mitochondrial fission and next be neutralized by a process termed mitophagy. A number of mitophagy pathways exist to specifically target
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Ling, Jiqiang. "Role of phenylalanyl-tRNA synthetase in translation quality control." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1212111223.

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Vigié, Pierre. "Mitochondrial quality control : roles of autophagy, mitophagy and the proteasome." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0202/document.

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La mitophagie, la dégradation sélective des mitochondries par autophagie, est impliquée dans l’élimination des mitochondries endommagées ou superflues et requiert des régulateurs et protéines spécifiques. Chez la levure, Atg32, localisée dans la membrane externe mitochondriale, interagit avec Atg8, et permet le recrutement des mitochondries et leur séquestration à l’intérieur des autophagosomes. Atg8 est conjuguée à de la phosphatidyléthanolamine et est ainsi ancrée aux membranes du phagophore et des autophagosomes. Chez la levure, plusieurs voies de synthèse de PE existent mais leur contribut
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Lingiah, Krishna Anand. "The role of DJ-1 in enhancing mitochondrial quality control." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12148.

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Thesis (M.A.)--Boston University<br>DJ-1 is a cytosolic sensor for oxidative damage which acts on the Mitochondria. It works to curb the negative effects of high membrane potential in mitochondria, but the mechanism of action is still uncertain. This study measured DJ-1’s potential in enchancing mitochondrial quality control in the context of pancreatic B-cells treated with a palmitate and glucose media to promote glucolipotoxicity (GLT). DJ-1 was proven capable of reversing GLT induced changed in mitochondrial morphology in the arenas of Feret’s diameter, aspect ratio, and form factor. We als
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Ng, Cheuk-Him (Andy). "Genome-Wide Screen Identifies Novel Genes Involved in Mitochondrial Quality Control." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/33204.

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In addition to ATP generation, mitochondria are essential in various cellular processes ranging from biosynthetic pathways, apoptosis, cell cycle progression, and calcium buffering. Studies in living cells have now firmly established that mitochondria exist as a dynamic network sculpted by fission and fusion reactions, rather than separated, individual organelles. Not surprisingly, mutations in genes involved in mitochondrial dynamics and quality control lead to human diseases such as Charcot-Marie-Tooth disease type 2A, Optic atrophy, and autosomal recessive Parkinson disease. I have designed
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Rüb, Cornelia [Verfasser]. "The Parkinson’s disease-related kinase Pink1 mediates mitochondrial quality control / Cornelia Rüb." Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/1119888662/34.

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Eira, da Costa Ana Carina. "Analysis of mitochondrial quality control using a Drosophila model of Parkinson's disease." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/28019.

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Parkinson’s disease (PD) is the most common neurodegenerative movement disorder. Despite recent advances, the cause for most PD cases remains unclear. The discovery of mutations in PINK1 (PTEN-induced putative kinase 1) reinforced the importance of mitochondrial impairment in PD. Mitochondria are essential organelles for energy generation in eukaryotic cells, whose compromise can eventually cause cell death. Multicellular organisms have evolved quality control mechanisms to ensure the viability of mitochondria and ultimately the cell. Molecular quality control through the mitochondrial chapero
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